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Clair-Yves BOQUIEN

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Chercheur en nutrition humaine ============================== Diplômes et fonctions --------------------- **1983 - Ingénieur Agronome Institut National Agronomique Paris-Grignon** **1988 - Docteur en Sciences des Aliments** **Chargé de Recherches Hors Classe - INRAE** ****Depuis 2010 - Directeur au sein du bureau de l’Association Européenne des Banques de lait (**[**EMBA**](https://europeanmilkbanking.com/)**)** et membre des groupes de travail (lait maternel, banques de lait)** **2015 - Directeur Centre de Recherche en Nutrition Humaine - Ouest** [**CRNH-Ouest**](http://www.crnh-ouest.fr/) **(depuis 2019) & directeur-adjoint (2015-2019)** **2020 - Membre commission d’évaluation CE21 (« Food and Food systems ») de l’Agence Nationale de la Recherche (ANR)** **2021 - Chargé de mission scientifique auprès du Haut Conseil de l'Evaluation de la Recherche et de l'Enseignement Supérieur (HCERES)** **1985-93 :** Doctorat et post-docs ------------------------------------ 1985-88 : Thèse en sciences (INRA Jouy-en-Josas) - 1988-89 : Post-doc à INRA Nouzilly 1989: Chargé Recherches INRA Thiverval-Grignon - **1988-89 Post-doc INRAE Tours - Nouzilly** - **1993 Post-doc à l’université CORNELL (Ithaca, NY)** Fermentation lactique et production d’arôme / texture de produits laitiers frais **1994-2004 :** Disponibilité INRA ---------------------------------- **Société DANONE -** Chef de projet au Centre de Recherche DANONE de Plessis-Robinson Fermentation lactique et propriétés organoleptiques des produits laitiers frais (yoghourts et fromages frais) Partenaire de plusieurs projets Européens (Programmes-cadres FP1 à FP3) **2005-2021** : Chargé de Recherches ------------------------------------- **UMR 1280 INRAE Université Nantes** [**PhAN**](http://www6.angers-nantes.inra.fr/phan) (Physio-pathologie des Adaptations Nutritionnelles) -------------------------------------------------------------------------------------------------------------------------------------------- *Thématique* : nutrition périnatale et programmation nutritionnelle - La composition nutritionnelle du lait maternel et les conséquences sur la croissance et la santé de l’enfant allaité, conformément à l’hypothèse de la programmation nutritionnelle. - Le flux de lait maternel de la mère à sa descendance dans des essais de supplémentation nutritonnelle dans un modèle animal *Compétences scientifiques en nutrition humaine, physiologie, et métabolisme* Compétences en recherche translationnelle, combinant les: \- Etudes sur cohorte, en collaboration étroite avec les cliniciens du service de Néonatologie du CHU de Nantes, (cohorte LACTACOL de nouveau-nés prématurés allaités) \- Etudes en expérimentation animale (Utilisation du modèle animal rongeur (rat) pour expérimentations de preuve de concept). - Auteur de plus de 50 publications scientifiques, les plus récentes dans le domaine de la nutrition périnatale et de la composition du lait maternel - Partenaire de projetsindustriels (Nestlé, France Bébé Nutrition) - Editeur à la revue *Nutrients* (décision éditoriale en *pre-* et *post-reviewing* de manuscrits) - Révision d'une dizaine de manuscrits par an - Organisateur de symposiums internationaux à Nantes et Membre du comité scientifique de plusieurs congrès internationaux sur le lait maternel & nutrition périnatale

Publications

Human milk oligosaccharides in breast milk and 2-year outcome in preterm infants: An exploratory analysis

Jean-Christophe Rozé , Mickael Hartweg , Laure Simon , Hélène Billard , Yipu Chen et al.
Clinical Nutrition, 2022, 41 (9), pp.1896-1905. ⟨10.1016/j.clnu.2022.07.024⟩
Journal articles hal-03748030v1

Breast milk protein content at week 3 after birth and neurodevelopmental outcome in preterm infants fed fortified breast milk

Clair-Yves Boquien , Helene Billard , Laure Simon , Cecile Boscher , Arnaud Legrand et al.
European Journal of Nutrition, 2021, pp.1-11. ⟨10.1007/s00394-021-02562-8⟩
Journal articles hal-03264328v1

Breast milk protein content at week 3 after birth and neurodevelopmental outcome in preterm infants fed fortified breast milk

Clair-Yves Boquien , Hélène Billard , Laure Simon , Cecile Boscher , Arnaud Legrand et al.
European Journal of Nutrition, 2021, 60 (7), pp.3959-3969. ⟨10.1007/s00394-021-02562-8⟩
Journal articles hal-03948500v1

Dietary Arginine Supplementation during Gestation and Lactation Increases Milk Yield and Mammary Lipogenesis in Rats

Thomas Sevrin , Charlène Sirvins , Agnès David , Audrey Aguesse , Alexis Gandon et al.
Journal of Nutrition, 2021, 151 (5), pp.2188-2198. ⟨10.1093/jn/nxab152⟩
Journal articles hal-03264334v1
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Correction: Alexandre-Gouabau et al. “Comprehensive Preterm Breast Milk Metabotype Associated with Optimal Infant Early Growth Pattern”, Nutrients, 2019, 11, 528

Marie Cécile Alexandre-Gouabau , Thomas Moyon , Agnes Sochard , François Fenaille , Sophie Cholet et al.
Nutrients, 2020, 12 (1), pp.162. ⟨10.3390/nu12010162⟩
Journal articles hal-02620488v1
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Fenugreek Stimulates the Expression of Genes Involved in Milk Synthesis and Milk Flow through Modulation of Insulin/GH/IGF-1 Axis and Oxytocin Secretion

Thomas Sevrin , Clair-Yves Boquien , Alexis Gandon , Isabelle Grit , Pierre de Coppet et al.
Genes, 2020, 11 (10), ⟨10.3390/genes11101208⟩
Journal articles hal-03209164v1
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Simultaneous exploration of nutrients and pollutants in human milk and their impact on preterm infant growth: An integrative cross-platform approach

German Cano Sancho , Marie Cécile Alexandre-Gouabau , Thomas Moyon , Anne-Lise Royer , Yann Guitton et al.
Environmental Research, 2020, 182, pp.109018. ⟨10.1016/j.envres.2019.109018⟩
Journal articles hal-02620289v1
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Letter to the editor: clarifying some aspects and the terminology of individualized human milk fortification

Sertac Arslanoglu , Caroline King , Clair-Yves Boquien , Delphine Lamireau , Paola Tonetto et al.
BMC Pediatrics, 2019, 19 (1), pp.135. ⟨10.1186/s12887-019-1491-x⟩
Journal articles inserm-02294624v1
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Comprehensive preterm breast milk metabotype associated with optimal infant early growth pattern

Marie Cécile Alexandre-Gouabau , Thomas Moyon , Agnes Sochard , François Fenaille , Sophie Cholet et al.
Nutrients, 2019, 11 (3), pp.1-26. ⟨10.3390/nu11030528⟩
Journal articles hal-02620327v1
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Recommendations for the establishment and operation of human milk banks in europe: A consensus statement from the european milk bank association (EMBA)

Gillian Weaver , Enrico Bertino , Corinna Gebauer , Anne Grovslien , Radmila Mileusnic-Milenovic et al.
Frontiers in Pediatrics, 2019, 7, pp.1-8. ⟨10.3389/fped.2019.00053⟩
Journal articles hal-02627234v1
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Fortification of human milk for preterm infants: update and recommendations of the european milk bank association (emba) working group on human milk fortification

Sertac Arslanoglu , Clair-Yves Boquien , Caroline King , Delphine Lamireau , Paola Tonetto et al.
Frontiers in Pediatrics, 2019, 7, ⟨10.3389/fped.2019.00076⟩
Journal articles hal-02628588v1
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Processing of donor human milk: update and recommendations from the european milk bank association (EMBA)

Guido E. Moro , Claude Billeaud , Buffin Rachel , Javier Calvo , Laura Cavallarin et al.
Frontiers in Pediatrics, 2019, 7, pp.1-10. ⟨10.3389/fped.2019.00049⟩
Journal articles hal-02620274v1
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Impact of Fenugreek on Milk Production in Rodent Models of Lactation Challenge

Thomas Sevrin , Marie Cécile Alexandre-Gouabau , Blandine Castellano , Audrey Aguesse , Khadija Ouguerram et al.
Nutrients, 2019, 11 (11), pp.2571. ⟨10.3390/nu11112571⟩
Journal articles hal-02463454v1
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Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants

Marie Cécile Alexandre-Gouabau , Thomas Moyon , Véronique Cariou , Jean-Philippe Antignac , El Mostafa Qannari et al.
Nutrients, 2018, 10 (2), pp.164. ⟨10.3390/nu10020164⟩
Journal articles hal-02429557v1
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Human Milk: An Ideal Food for Nutrition of Preterm Newborn

Clair-Yves Boquien
Frontiers in Pediatrics, 2018, 6, pp.1-9. ⟨10.3389/fped.2018.00295⟩
Journal articles hal-02623706v1

Le lait maternel : un aliment idéal pour la nutrition du nouveau-né (En lien avec sa croissance et son devenir neuro-moteur)

Clair-Yves Boquien
Cahiers de Nutrition et de Diététique, 2018, ⟨10.1016/j.cnd.2018.07.003⟩
Journal articles hal-02625028v1
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Use of water turnover method to measure mother's milk flow in a rat model: Application to dams receiving a low protein diet during gestation and lactation.

Thomas Sevrin , Marie Cécile Alexandre-Gouabau , Dominique Darmaun , Antoine Palvadeau , Agnès André et al.
PLoS ONE, 2017, 12 (7), pp.e0180550. ⟨10.1371/journal.pone.0180550⟩
Journal articles hal-01607230v1
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Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report

Nhat Thang Tran , Marie Cécile Alexandre-Gouabau , Anthony Pagniez , Khadija Ouguerram , Clair-Yves Boquien et al.
Nutrients, 2017, 9 (4), pp.1-15. ⟨10.3390/nu9040375⟩
Journal articles hal-01607137v1
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Higher Leptin but Not Human Milk Macronutrient Concentration Distinguishes Normal-Weight from Obese Mothers at 1-Month Postpartum

Arnaud de Luca , Marine Frasquet-Darrieux , Marie-Agnes Gaud , Patricia Christin , Clair-Yves Boquien et al.
PLoS ONE, 2016, 11 (12), pp.e0168568. ⟨10.1371/journal.pone.0168568⟩
Journal articles hal-02141337v1

Calibration Adjustment of the Mid-infrared Analyzer for an Accurate Determination of the Macronutrient Composition of Human Milk

Hélène Billard , Laure Simon , Emmanuelle Desnots , Agnes Sochard , C. Boscher et al.
Journal of Human Lactation, 2016, 32 (3), pp.19-27. ⟨10.1177/0890334415588513⟩
Journal articles hal-01487353v1

High protein intake in neonatal period induces glomerular hypertrophy and sclerosis in adulthood in rats born with IUGR

Farid Boubred , Eloise E. Delamaire , Christophe Buffat , Laurent Daniel , Clair-Yves Boquien et al.
Pediatric Research, 2016, 79 (1), pp.22-26. ⟨10.1038/pr.2015.176⟩
Journal articles hal-02633522v1

Country-specific chemical signatures of persistent organic pollutants (POPs) in breast milk of French, Danish and Finnish women

Jean-Philippe Antignac , K. M. Main , H. E. Virtanen , Clair-Yves Boquien , P. Marchand et al.
Environmental Pollution, 2016, 218, pp.728-738. ⟨10.1016/j.envpol.2016.07.069⟩
Journal articles hal-02637397v1

Higher concentrations of branched-chain amino acids in breast milk of obese mothers

Arnaud de Luca , Regis Hankard , Marie Cécile Alexandre-Gouabau , Veronique Ferchaud Roucher , Dominique Darmaun et al.
Nutrition, 2016, 32 (11-12), pp.1295-1298. ⟨10.1016/j.nut.2016.05.013⟩
Journal articles hal-01605046v1
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Projet MANOE, Maîtrise Allergène NutritiOn Enfant. Etude de la réactivité de patients allergiques à des faibles doses d'allergènes (blé, œuf, lait, arachide). Détection et quantification des allergènes présents à faibles doses dans des matrices alimentaires complexes

Olivier Tranquet , Valerie Echasserieau-Laporte , Herve Bernard , Clair-Yves Boquien , Thomas Moyon et al.
Innovations Agronomiques, 2016, 52, pp.27-35. ⟨10.15454/1.513583543955866E12⟩
Journal articles hal-01652907v1
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MiRNA Analysis by Quantitative PCR in Preterm Human Breast Milk Reveals Daily Fluctuations of hsa-miR-16-5p

Ilaria Floris , Hélène Billard , Clair-Yves Boquien , Evelyne Joram-Gauvard , Laure Simon et al.
PLoS ONE, 2015, 10 (10), ⟨10.1371/journal.pone.0140488⟩
Journal articles hal-02641551v1

Perinatal protein restriction affects milk free amino acid and fatty acid profile in lactating rats: potential role on pup growth and metabolic status

Aurore Martin-Agnoux , Jean-Philippe Antignac , Clair-Yves Boquien , Agnès David , Emmanuelle Desnots et al.
Journal of Nutritional Biochemistry, 2015, 26 (7), pp.784-795. ⟨10.1016/j.jnutbio.2015.02.012⟩
Journal articles hal-02634633v1

Determination of bisphenol A and related substitutes/analogues in human breast milk using gas chromatography-tandem mass spectrometry

Yoann Deceuninck , Emmanuelle Bichon , Philippe Marchand , Clair-Yves Boquien , Arnaud Legrand et al.
Analytical and Bioanalytical Chemistry, 2015, 407 (9), pp.2485 - 2497. ⟨10.1007/s00216-015-8469-9⟩
Journal articles hal-02637449v1

Maternal supplementation with n-3 long chain polyunsaturated fatty acids during perinatal period alleviates the metabolic syndrome disturbances in adult hamster pups fed a high-fat diet after weaning

Fatima Kasbi-Chadli , Clair-Yves Boquien , Gilles Simard , Lionel Ulmann , Virginie Mimouni et al.
Journal of Nutritional Biochemistry, 2014, 25 (7), pp.726-733. ⟨10.1016/j.jnutbio.2014.03.003⟩
Journal articles hal-02636983v1
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Use of UPLC-ESI-MS/MS to quantitate free amino acid concentrations in micro-samples of mammalian milk.

Véronique Ferchaud Roucher , Emmanuelle Desnots , Charlotte Nael , Aurore Martin Agnoux , Marie Cécile Alexandre-Gouabau et al.
SpringerPlus, 2013, 2, pp.622. ⟨10.1186/2193-1801-2-622⟩
Journal articles hal-02647300v1
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The apparent breastfeeding paradox in very preterm infants: relationship between breast feeding, early weight gain and neurodevelopment based on results from two cohorts, EPIPAGE and LIFT

Jean-Christophe Rozé , Dominique Darmaun , Clair-Yves Boquien , Cyril Flamant , Jean-Charles Picaud et al.
BMJ Open, 2012, 2 (2), ⟨10.1136/bmjopen-2012-000834⟩
Journal articles hal-02651908v1

Long term metabolic impact of high protein neonatal feeding

Eloise Delamaire , Patricia Parnet , Berengere Coupe , Christine Hoebler , Sophie Blat et al.
Clinical Nutrition, 2012, 31 (5), pp.741-748. ⟨10.1016/j.clnu.2012.02.005⟩
Journal articles hal-01415274v1

Development of an analytical strategy based on liquidchromatography-high resolution mass spectrometry for measuringperfluorinated compounds in human breast milk: Application to thegeneration of preliminary data regarding perinatal exposure in France

Hanane Kadar , Bruno Veyrand , Andrea Barbarossa , Giampiero Pagliuca , Arnaud Legrand et al.
Chemosphere, 2011, 85 (3), pp.473 - 480. ⟨10.1016/j.chemosphere.2011.07.077⟩
Journal articles hal-02644361v1

Microbial dynamics of co- and separately entrapped mixed cultures of mesophilic lactic acid bacteria during the continuous prefermentation of milk

I. Sodini , Clair-Yves Boquien , Georges Corrieu , C. Lacroix
Enzyme and Microbial Technology, 1997, 20, pp.381-388
Journal articles hal-02697444v1

Use of an immobilized cell bioreactor for the continuous inoculation of milk in fresh cheese manufacturing

I. Sodini , Clair-Yves Boquien , Georges G. Corrieu , C. Lacroix
Journal of Industrial Microbiology and Biotechnology, 1997, 18 (1), pp.56-61. ⟨10.1038/sj.jim.2900362⟩
Journal articles hal-02695477v1

Reusable solid phase immunoassay for the detection of citrate lyase

C. Joyeux , E. Chrzavzez , Clair-Yves Boquien , D. Picque , Georges Corrieu et al.
Analytica Chimica Acta, 1996, 320, pp.77-86
Journal articles hal-02690813v1

Improvement of diacetyl production by Lactococcus lactis ssp. lactis CNRZ 483 through oxygen control

H. Boumerdassi , M. Desmazeaud , Christophe C. Monnet , Clair-Yves Boquien , Georges Corrieu et al.
Journal of Dairy Science, 1996, 79, pp.775-781
Journal articles hal-02693291v1

Quantification of citrate lyase by enzyme-linked immunosorbent assay for determining the population of Lactococcus lactis subsp. lactis biovar diacetylactis in pure and mixed cultures

P.F. David , Clair-Yves Boquien , F. Nakache , N. Bassit , D. Hartley et al.
Applied Microbiology and Biotechnology, 1995, 44 (1-2), pp.68-74
Journal articles hal-02706973v1

Process performance of continuous inoculation and acidification of milk with immobilized lactic acid bacteria

I. Sodini-Gallot , Georges Corrieu , Clair-Yves Boquien , Eric Latrille , C. Lacroix et al.
Journal of Dairy Science, 1995, 78, pp.1407-1420
Journal articles hal-02704994v1

Effect of temperature on diacetyl and acetoin production by Lactococcus lactis subsp. lactis biovar diacetilactis CNRZ 483

N. Bassit , Clair-Yves Boquien , D. Picque , Georges Corrieu
Journal of Dairy Research, 1995, 62, pp.123-129
Journal articles hal-02713704v1

Influence of dilution rate and cell immobilization on plasmid stability during continuous cultures of recombinant strains of Lactococcus lactis subsp. lactis

Christine d'Angio , Catherine Béal , Clair-Yves Boquien , Georges Corrieu
Journal of Biotechnology, 1994, 34 (1), pp.87-95
Journal articles hal-02706891v1

Methods for the determination of aroma compounds in dairy products : a comparative study

V. Xanthopoulos , D. Picque , N. Bassit , Clair-Yves Boquien , Georges Corrieu et al.
Journal of Dairy Research, 1994, 61 (2), pp.289-297
Journal articles hal-02707272v1
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Effet combiné de l'oxygène et de la température sur l'acidification et les productions de diacétyle et d'acétoïne par Lactococcus lactis subsp lactis biovar diacetylactis

N Bassit , E Latrille , Clair-Yves Boquien , D Picque , G Corrieu et al.
Le Lait, 1994, 74 (2), pp.115-126
Journal articles hal-00929382v1

Plasmid stability in recombinant strains of Lactococcus lactis subsp. lactis during continuous culture

Christine d'Angio , Catherine Béal , Clair-Yves Boquien , Philippe P. Langella , Georges Corrieu et al.
FEMS Microbiology Letters, 1994, 116 (1), pp.25-30
Journal articles hal-02706358v1

Effect of initial oxygen concentration on diacetyl and acetoin production by Lactococcus lactis subsp. lactis biovar diacetylactis

N. Bassit , Clair-Yves Boquien , D. Picque , Georges Corrieu
Applied and Environmental Microbiology, 1993, 59 (6), pp.1893-1897
Journal articles hal-02711819v1

L'apport de l'immunochimie en agroalimentaire

Clair-Yves Boquien
Immunoanalyse et Biologie Spécialisée, 1993, 2, pp.81-88
Journal articles hal-02710931v1

Localization of peptidases in lactococci

P.S.T. Tan , Marie-Pierre Chapot Chartier , K.M. Pos , M. Rousseau , Clair-Yves Boquien et al.
Applied and Environmental Microbiology, 1992, 58 (1), pp.285-290
Journal articles hal-02707933v1

Batch cultures of recombinant Lactococcus lactis subsp. lactis in a stirred fermentor. I. Effect of plasmid content on bacterial growth and on genetic stability in pure cultures

N. El Alami , Clair-Yves Boquien , Georges Corrieu
Applied Microbiology and Biotechnology, 1992, 37 (3), pp.358-363
Journal articles hal-02703024v1

Batch cultures of recombinant Lactococcus lactis subsp. lactis in a stirred fermentor. II. Plasmid transfer in mixed cultures

N. El Alami , Clair-Yves Boquien , Georges Corrieu
Applied Microbiology and Biotechnology, 1992, 37 (3), pp.364-368
Journal articles hal-02703027v1

Ultrasound treatment for harvesting an aminopeptidase from lactic acid bacteria and quantitation of the enzyme by enzyme-linked immunosorbent assays

Clair-Yves Boquien , F. Nakache , A. Paraf
Applied and Environmental Microbiology, 1991, 57 (8), pp.2211-2216
Journal articles hal-02709309v1

Caracterisation d'une aminopeptidase chez Streptococcus cremoris AM2 et d'une alpha-galactosidase chez Leuconostoc lactis CNRZ 1091

Clair-Yves Boquien , M.J. Desmazeaud , Georges Corrieu
Lait, 1989, 69, pp.71-81
Journal articles hal-02724365v1
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Caractérisation d'une aminopeptidase chez Streptococcus cremoris AM2 et d'une α-galactosidase chez Leuconostoc lactis CNRZ 1091

Clair-Yves Boquien , M.J. Desmazeaud , G. Corrieu
Le Lait, 1989, 69 (1), pp.71-81
Journal articles hal-00929150v1

Purification and characterization of an aminopeptidase from Lactococcus lactis subsp. cremoris AM2

E. Neviani , Clair-Yves Boquien , V. Monnet , Luu Phan Thanh , J.C. Gripon et al.
Applied and Environmental Microbiology, 1989, 55 (9), pp.2308-2314
Journal articles hal-02721915v1

Enzymatic methods for determining populations of Streptococcus cremoris AM2 and Leuconostoc lactis CNRZ 1091 in pure and mixed cultures

Clair-Yves Boquien , Georges Corrieu , M.J. Desmazeaud
Applied Microbiology and Biotechnology, 1989, 30 (4), pp.402-407
Journal articles hal-02727478v1

Effect of fermentation conditions on growth of Streptococcus cremoris AM2 and Leuconostoc lactis CNRZ 1091 in pure and mixed cultures

Clair-Yves Boquien , Georges Corrieu , J. Desmazeaud
Applied and Environmental Microbiology, 1988, 54 (10), pp.2527-2531
Journal articles hal-02722294v1

Phenomenes de cooperation et d'inhibition entre les bacteries lactiques utilisees en industrie laitiere

Vincent Juillard , Henry-Eric Spinnler , M. Desmazeaud , Clair-Yves Boquien
Lait, 1987, 67, pp.149-172
Journal articles hal-02726095v1
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Phénomènes de coopération et d'inhibition entre les bactéries lactiques utilisées en industrie laitière

V. Juillard , H.E. Spinnler , M.J. Desmazeaud , Clair-Yves Boquien
Le Lait, 1987, 67 (2), pp.149-172
Journal articles hal-00929090v1