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Claire Wyart



Date of birth: **Feb. 16, 1977** Position: **Group leader in the Paris Brain Institute (ICM)** **INSERM Director of Research** Citizenships: **France &amp; USA** Dependents: **3 children** Education Institution Diploma Years Major Ecole Normale Supérieure Ulm, Paris Bachelor Master 1996-2000 Biology Neurosciences Institute of Physics, Strasbourg PhD 2000-2003 Neurosciences &amp; Biophysics Address Institut du Cerveau (ICM), INSERM U1127, 47 bld hopital, 75013 Paris, France Email: <> Phone: +33 157 274 310 Websites Lab <> ~ <> ~ Outreach <> Positions 2017 Promotion to Inserm Research Director (DR2) 2011 Group Leader ATIP-Avenir, Institut du Cerveau (ICM), France 2011 Inserm Researcher Position through national competitive selection (CR1) 2009-10 Life Science Research Associate, Mol. &amp; Cell. Biology, UC Berkeley, USA 2005-09 Postdoctoral Fellow, Molecular and Cellular Biology dept, UC Berkeley, USA Prizes 2019 Elected EMBO member Grand Prix of Mrs. Victor Noury from the French National Academy 2017 EMBO-Young Investigator Program (EMBO-YIP) Award Foundation Science Education Research (FSER) First Prize of the jury 2016 New York Stem Cell Foundation Robertson Innovator Neuroscience Award 2013 Irène Joliot-Curie Prize for women in science 2011 Prize Atip-Avenir of the Bettencourt-Schueller Foundation (FBS) Emergence Prize from the City of Paris 2010 Chair of Excellence of School of Neurosciences of Paris (ENP) 2005 Prize of the Foundation Blancmesnil for the documentary TERMA 2004 Best PhD from Louis Pasteur University Coordination of research programs 2020 European Research Council (ERC) - Consolidator grant Fondation Recherche Médicale (FRM) Team label 2018 European Research Council - Proof of Concept Grant Human Frontier Research Program (HFSP) coordinator 2016 New York Stem Cell Foundation (NYSCF) award 2013 Human Frontier Research Program (HFSP) coordinator 2012 European Research Council - Starting Grant Scientific board &amp; committees 2020-23 Fondation Recherche Médicale (FRM) 2018-21 FENS-Kavli Network of Excellence board member 2017-20 Fondation Cotrel 2016-21 FENS-Kavli Network of Excellence scholar 2016 CNRS Selection committee for researchers in neurosciences (CNRS#25) Member of editorial committee Current Biology (2017-now), eLife (2018-now), Current Opinion in Physiology (2018-19). Publications and conferences ∞ 60 publications in journals including *Nature (1), Science (2), Nature Methods (1), eLife (4), Neuron (1), Nature Communications (3), Nature Neuroscience (1), Current Biology (6)*. ∞ &gt; 50 invitations to present at international conferences since 2016. ∞ &gt; 20 invitations to give a seminar in an institute since 2016. Researcher ID ORCID: 0000-0002-1668-4975 &amp; Web Of Science: AAB-4603-2020


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Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS

Claire Wyart , Martin Carbo-Tano , Yasmine Cantaut-Belarif , Adeline Orts-Del’immagine , Urs L Böhm
Nature Reviews Neuroscience, 2023, 24 (9), pp.540-556. ⟨10.1038/s41583-023-00723-8⟩
Journal articles hal-04192775v1
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Loss of CSF-contacting neuron sensory function is associated with a hyper-kyphosis of the spine reminiscent of Scheuermann’s disease

Laura Marie-Hardy , Lotfi Slimani , Giulia Messa , Zaineb El Bourakkadi , Annick Prigent
Scientific Reports, 2023, 13 (5529), ⟨10.1038/s41598-023-32536-1⟩
Journal articles hal-04064556v1
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CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection

Andrew Prendergast , Kin Ki Jim , Hugo Marnas , Laura Desban , Feng Quan
Current Biology - CB, 2023, 33 (5), pp.940-956.e10. ⟨10.1016/j.cub.2023.01.039⟩
Journal articles hal-04032555v1
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A lexical approach for identifying behavioural action sequences

Gautam Reddy , Laura Desban , Hidenori Tanaka , Julian Roussel , Olivier Mirat
PLoS Computational Biology, 2022, 18 (1), pp.e1009672. ⟨10.1371/journal.pcbi.1009672⟩
Journal articles hal-03521462v1
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Evolutionary divergence of locomotion in two related vertebrate species

Gokul Rajan , Julie Lafaye , Martin Carbo-Tano , Karine Duroure , Giulia Faini
Cell Reports, 2022, 38 (13), pp.110585. ⟨10.1016/j.celrep.2022.110585⟩
Journal articles hal-03142570v2
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Spinal sensory neurons project onto hindbrain to stabilize posture and enhance locomotor speed

Ming-Yue Wu , Martin Carbó-Tano , Olivier Mirat , Francois-Xavier Lejeune , Julian Roussel
Current Biology - CB, 2021, ⟨10.1016/j.cub.2021.05.042⟩
Journal articles hal-03334718v1
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Automated Analysis of Cerebrospinal Fluid Flow and Motile Cilia Properties in The Central Canal of Zebrafish Embryos

Olivier Thouvenin , Yasmine Cantaut-Belarif , Ludovic Keiser , Francois Gallaire , Claire Wyart
Bio-protocol , 2021, 11 (5), ⟨10.21769/BioProtoc.3932⟩
Journal articles hal-03191555v1
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A calibrated optogenetic toolbox of stable zebrafish opsin lines

Paride Antinucci , Adna Dumitrescu , Charlotte Deleuze , Holly Morley , Kristie Leung
Journal articles hal-02540191v1
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Experience, circuit dynamics, and forebrain recruitment in larval zebrafish prey capture

Claire S Oldfield , Irene Grossrubatscher , Mario Chavez , Adam Hoagland , Alex R Huth
eLife, 2020, 9, pp.e56619. ⟨10.7554/eLife.56619⟩
Journal articles hal-03019795v1
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Adrenergic activation modulates the signal from the Reissner fiber to cerebrospinal fluid-contacting neurons during development

Yasmine Cantaut-Belarif , Adeline Orts Del'Immagine , Margot Penru , Guillaume Pézeron , Claire Wyart
Journal articles hal-02975594v1
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Somatostatin 1.1 contributes to the innate exploration of zebrafish larva

Feng B Quan , Laura Desban , Olivier Mirat , Maxime Kermarquer , Julian Roussel
Scientific Reports, 2020, 10, pp.15235. ⟨10.1038/s41598-020-72039-x⟩
Journal articles mnhn-02943951v1
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Origin and role of the cerebrospinal fluid bidirectional flow in the central canal

Olivier Thouvenin , Ludovic Keiser , Yasmine Cantaut-Belarif , Martin Carbo-Tano , Frederik J. Verweij
eLife, 2020, 9, pp.e47699. ⟨10.7554/eLife.47699⟩
Journal articles hal-02489664v1
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Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities

Valerie Bercier , Jeffrey Hubbard , Kevin Fidelin , Karine Duroure , Thomas O Auer
Molecular Neurodegeneration, 2019, 14 (1), pp.27. ⟨10.1186/s13024-019-0327-3⟩
Journal articles hal-02273092v1
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Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons

Laura Desban , Andrew Prendergast , Julian Roussel , Marion Rosello , David Geny
PLoS Biology, 2019, 17 (4), pp.e3000235. ⟨10.1371/journal.pbio.3000235⟩
Journal articles hal-02136729v1
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Title Taking a big step towards understanding locomotion Authors list

Claire Wyart
Trends in Neurosciences, 2018, 41 (12), pp.869-870
Journal articles hal-01971726v1
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Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature

Jenna Sternberg , Andrew Prendergast , Lucie Brosse , Yasmine Cantaut-Belarif , Olivier Thouvenin
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-06225-x⟩
Journal articles hal-01918990v1
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Multiplexed temporally focused light shaping for high-resolution multi-cell targeting

Nicolò Accanto , Clément Molinier , Dimitrii Tanese , Emiliano Ronzitti , Zachary L. Newman
Optica, 2018, 5 (11), pp.1478-1491
Journal articles hal-01945948v1
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Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion

Steven Knafo , Kevin Fidelin , Andrew Prendergast , Po-En Brian Tseng , Alexandre Parrin
eLife, 2017, 2017 (6), pp.e25260. ⟨10.7554/eLife.25260⟩
Journal articles hal-01954973v1
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The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes

Lydia Djenoune , Laura Desban , Johanna Gomez , Jenna R. Sternberg , Andrew Prendergast
Scientific Reports, 2017, 7 (1), pp.719. ⟨10.1038/s41598-017-00350-1⟩
Journal articles hal-01516797v1
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Remote z-scanning with a macroscopic voice coil motor for fast 3D multiphoton laser scanning microscopy

Peter Rupprecht , Andrew Prendergast , Claire Wyart , Rainer W. Friedrich
Biomedical optics express, 2016, 7 (5), pp.1656-1671. ⟨10.1364/BOE.7.001656⟩
Journal articles hal-01327206v1
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CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits

Urs Lucas Böhm , Andrew Prendergast , Lydia Djenoune , Sophie Nunes Figueiredo , Johanna Gomez
Nature Communications, 2016, 7, pp.10866 ⟨10.1038/ncomms10866⟩
Journal articles hal-01285569v1
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Three-dimensional spatiotemporal focusing of holographic patterns

Oscar Hernandez , Eirini Papagiakoumou , Dimitrii Tanese , Kevin Fidelin , Claire Wyart
Nature Communications, 2016, 7 (1), ⟨10.1038/ncomms11928⟩
Journal articles hal-01963770v1
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Spinal sensory circuits in motion

Urs Lucas Böhm , Claire Wyart
Current Opinion in Neurobiology, 2016, 41, pp.38-43. ⟨10.1016/j.conb.2016.07.007⟩
Journal articles hal-01371943v1
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Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion

Jeffrey michael Hubbard , Urs lucas Böhm , Andrew Prendergast , Po-En brian Tseng , Morgan Newman
Current Biology - CB, 2016, ⟨10.1016/j.cub.2016.08.026⟩
Journal articles hal-01382762v1
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State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons

Kevin Fidelin , Lydia Djenoune , Caleb Stokes , Andrew Prendergast , Johanna Gómez
Current Biology - CB, 2015, 25 (23), pp.3035-3047. ⟨10.1016/j.cub.2015.09.070⟩
Journal articles hal-01941112v1
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Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3

Thomas O. Auer , Tong Xiao , Valerie Bercier , Christoph Gebhardt , Karine Duroure
eLife, 2015, 4, pp.e05061. ⟨10.7554/eLife.05061.030⟩
Journal articles hal-01214787v1

Comparative Distribution and In Vitro Activities of the Urotensin II-Related Peptides URP1 and URP2 in Zebrafish: Evidence for Their Colocalization in Spinal Cerebrospinal Fluid-Contacting Neurons

Feng Quan , Christophe Dubessy , Sonya Galant , Natalia Kenigfest , Lydia Djenoune
PLoS ONE, 2015, 10 (3), pp.e0119290. ⟨10.1371/journal.pone.0119290⟩
Journal articles hal-03281679v1
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Comparative Distribution and In Vitro Activities of the Urotensin II-Related Peptides URP1 and URP2 in Zebrafish: Evidence for Their Colocalization in Spinal Cerebrospinal Fluid-Contacting Neurons

Feng B. Quan , Christophe Dubessy , Sonya Galant , Natalia B. Kenigfest , Lydia Djenoune
PLoS ONE, 2015, 10 (3), pp.e0119290. ⟨10.1371/journal.pone.0119290⟩
Journal articles hal-01227829v1
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Fast Calcium Imaging with Optical Sectioning via HiLo Microscopy

Marcel A. Lauterbach , Emiliano Ronzitti , Jenna R. Sternberg , Claire Wyart , Valentina Emiliani
PLoS ONE, 2015, 10 (12), pp.e0143681. ⟨10.1371/journal.pone.0143681⟩
Journal articles hal-01272977v1
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Endothelial Cilia Mediate Low Flow Sensing during Zebrafish Vascular Development

Jacky G. Goetz , Emily Steed , Rita R. Ferreira , Stéphane Roth , Caroline Ramspacher
Cell Reports, 2014, 6 (5), pp.799-808. ⟨10.1016/j.celrep.2014.01.032⟩
Journal articles hal-01311698v1
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Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates

Lydia Djenoune , Hanen Khabou , Fanny Joubert , Feng B. Quan , Sophie Nunes Figueiredo
Frontiers in Neuroanatomy, 2014, 8, pp.26. ⟨10.3389/fnana.2014.00026⟩
Journal articles hal-01321299v1

Hierarchy of Neural Organization in the Embryonic Spinal Cord: Granger-Causality Graph Analysis of Calcium Imaging Data

Fabrizio de Vico Fallani , Martina Corazzol , Jenna Sternberg , Claire Wyart , Mario Chavez
IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2014, pp.10. ⟨10.1109/TNSRE.2014.2341632⟩
Journal articles hal-01112731v1
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ZebraZoom: an automated program for high-throughput behavioral analysis and categorization

Olivier Mirat , Jenna R. Sternberg , Kristen E. Severi , Claire Wyart
Frontiers in Neural Circuits, 2013, 7, pp.107. ⟨10.3389/fncir.2013.00107⟩
Journal articles hal-01578454v1

Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway

Elim Hong , Kirankumar Santhakumar , Courtney A. Akitake , Sang Jung Ahn , Christine Thisse
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (52), pp.21171-21176. ⟨10.1073/pnas.1319566110⟩
Journal articles hal-01542736v1

Dynamics of excitatory synaptic components in sustained firing at low rates.

Claire Wyart , Simona Cocco , Laurent Bourdieu , Jean-Francois Léger , Catherine Herr
Journal of Neurophysiology, 2005, 93 (6), pp.3370-80. ⟨10.1152/jn.00530.2004⟩
Journal articles hal-00145309v1

Constrained synaptic connectivity in functional mammalian neuronal networks grown on patterned surfaces.

Claire Wyart , Christophe Ybert , Laurent Bourdieu , Catherine Herr , Christelle Prinz
Journal of Neuroscience Methods, 2002, 117 (2), pp.123-31
Journal articles hal-00145442v1