claude sardet

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Replication-poison treatment in BRCA1-deficient breast cancer causes MRE11 over-resection that induces single-stranded DNA accumulation and Mitotic Catastrophe

Imene Tabet , Esin Orhan , Ermes Candiello , Lise Fenou , Carolina Velázquez et al.
Article dans une revue (data paper) hal-04931535 v1
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CDK inhibition results in pharmacologic BRCAness increasing sensitivity to olaparib in BRCA1-WT and olaparib resistant in Triple Negative Breast Cancer

Esin Orhan , Carolina Velazquez , Imene Tabet , Lise Fenou , Geneviève Rodier et al.
Cancer Letters, 2024, 589, pp.216820. ⟨10.1016/j.canlet.2024.216820⟩
Article dans une revue hal-04535765 v1
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BRCA1-methylated triple negative breast cancers previously exposed to neoadjuvant chemotherapy form RAD51 foci and respond poorly to olaparib

Carolina Velazquez , Esin Orhan , Imene Tabet , Lise Fenou , Béatrice Orsetti et al.
Frontiers in Oncology, 2023, 13, pp.1125021. ⟨10.3389/fonc.2023.1125021⟩
Article dans une revue hal-04275543 v1
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In high grade ovarian carcinoma, platinum-sensitive tumor recurrence and acquired-resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6 and SOX2

Stanislas Du Manoir , Hélène Delpech , Béatrice Orsetti , William Jacot , Nelly Pirot et al.
Journal of Pathology, 2022, 257 (3), Online ahead of print. ⟨10.1002/path.5896⟩
Article dans une revue inserm-03613881 v1
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RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation

Aude Guénolé , Fabien Velilla , Aymeric Chartier , April Rich , Anne-Ruxandra Carvunis et al.
Scientific Reports, 2022, 12 (1), pp.9288. ⟨10.1038/s41598-022-13309-8⟩
Article dans une revue hal-04275608 v1
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Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer

Kalil Batnini , Thibault Houles , Olivier Kirsh , Stanislas Du Manoir , Mehdi Zaroual et al.
International Journal of Molecular Sciences, 2022, 23 (16), pp.9217. ⟨10.3390/ijms23169217⟩
Article dans une revue hal-03845417 v1
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Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition

Simon Hayek , Nicolas Pietrancosta , Anna Hovhannisyan , Rodolphe Alves de Sousa , Nassima Bekaddour et al.
European Journal of Medicinal Chemistry, 2020, 186, pp.111855. ⟨10.1016/j.ejmech.2019.111855⟩
Article dans une revue hal-02372490 v1
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Distinct oncogenes drive different genome and epigenome alterations in human mammary epithelial cells

Claire Fonti , Anne Saumet , Amanda Abi-Khalil , Béatrice Orsetti , Elouan Cleroux et al.
International Journal of Cancer, 2019, 145 (5), pp.1299-1311. ⟨10.1002/ijc.32413⟩
Article dans une revue inserm-02177754 v1
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Coprs inactivation leads to a derepression of LINE1 transposons in spermatocytes

Conception Paul , Hélène Delpech , Delphine Haouzi , Samir Hamamah , Claude Sardet et al.
FEBS Open Bio, 2019, ⟨10.1002/2211-5463.12562⟩
Article dans une revue hal-02414875 v1
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Cell-cycle regulation of non-enzymatic functions of the Drosophila methyltransferase PR-Set7

Amel Zouaz , Céline Fernando , Yannick Perez , Claude Sardet , Eric Julien et al.
Nucleic Acids Research, 2018, 46 (6), pp.2834-2849. ⟨10.1093/nar/gky034⟩
Article dans une revue hal-02292938 v1

Histone H4K20 tri‐methylation at late‐firing origins ensures timely heterochromatin replication

Julien Brustel , Nina Kirstein , Fanny Izard , Charlotte Grimaud , Paulina Prorok et al.
EMBO Journal, 2017, 36 (18), pp.2726-2741. ⟨10.15252/embj.201796541⟩
Article dans une revue hal-02154100 v1
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Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition

Stéphanie Arnould , Genevieve Rodier , Gisèle Matar , Charles Vincent , Nelly Pirot et al.
Oncotarget, 2017, 8 (56), pp.95206 - 95222. ⟨10.18632/oncotarget.19199⟩
Article dans une revue hal-02291385 v1

Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition

Stéphanie Arnould , Geneviève Rodier , Gisèle Matar , Charles Vincent , Nelly Pirot et al.
Oncotarget, 2017, 8 (56), pp.95206-95222. ⟨10.18632/oncotarget.19199⟩
Article dans une revue hal-04766813 v1
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E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity

Matthieu Lacroix , Geneviève Rodier , Olivier Kirsh , Thibault Houles , Hélène Delpech et al.
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (39), pp.10998-11003. ⟨10.1073/pnas.1602754113⟩
Article dans une revue hal-01837650 v1
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E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis

Perrine Goguet-Rubio , Berfin Seyran , Laurie Gayte , Florence F. Bernex , Anne Sutter et al.
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (39), pp.11004-11009. ⟨10.1073/pnas.1602751113⟩
Article dans une revue inserm-02465232 v1

Description of an optimized ChIP-seq analysis pipeline dedicated to genome wide identification of E4F1 binding sites in primary and transformed MEFs

Thibault Houlès , Geneviève Rodier , Laurent Le Cam , Claude Sardet , Olivier Kirsh
Genomics Data, 2015, 5, pp.368-370. ⟨10.1016/j.gdata.2015.07.004⟩
Article dans une revue hal-04766820 v1
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The Transcription Factor E4F1 Coordinates CHK1-Dependent Checkpoint and Mitochondrial Functions

Geneviève Rodier , Olivier Kirsh , Martín Baraibar , Thibault Houlès , Matthieu Lacroix et al.
Cell Reports, 2015, 11 (2), pp.220-233. ⟨10.1016/j.celrep.2015.03.024⟩
Article dans une revue hal-01213872 v1
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The Wnt-target gene Dlk-1 is regulated by the Prmt5-associated factor Copr5 during adipogenic conversion

Conception Paul , Claude Sardet , Eric Fabbrizio
Biology Open, 2015, 4 (3), pp.312-316. ⟨10.1242/bio.201411247⟩
Article dans une revue hal-02277973 v1

The Transcription Factor E4F1 Coordinates CHK1-Dependent Checkpoint and Mitochondrial Functions

Geneviève Rodier , Olivier Kirsh , Martín Baraibar , Thibault Houlès , Matthieu Lacroix et al.
Cell Reports, 2015, 11 (2), pp.220-233. ⟨10.1016/j.celrep.2015.03.024⟩
Article dans une revue hal-04766824 v1

Description of an optimized ChIP-seq analysis pipeline dedicated to genome wide identification of E4F1 binding sites in primary and transformed MEFs

Thibault Houles , Geneviève Rodier , Laurent Le Cam , Claude Sardet , Olivier Kirsh
Genomics Data, 2015, 5, pp.368-370. ⟨10.1016/j.gdata.2015.07.004⟩
Article dans une revue hal-02317536 v1

E4F1 dysfunction results in autophagic cell death in myeloid leukemic cells

Elodie Hatchi , Geneviève Rodier , Claude Sardet , Laurent Le Cam
Autophagy, 2014, 7 (12), pp.1566-1567. ⟨10.4161/auto.7.12.17991⟩
Article dans une revue hal-04766830 v1

PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome

Michael Girardot , Ryutaro Hirasawa , Salim Kacem , Lauriane Fritsch , Julien Pontis et al.
Nucleic Acids Research, 2014, 42 (1), pp.235-248. ⟨10.1093/nar/gkt884⟩
Article dans une revue hal-03051652 v1

Leukoencephalopathy with cysts and hyperglycinemia may result from NFU1 deficiency

M. Nizon , A. Boutron , N. Boddaert , A. Slama , Hélène Delpech et al.
Mitochondrion, 2014, 15, pp.59--64. ⟨10.1016/j.mito.2014.01.003⟩
Article dans une revue hal-02181366 v1
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PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome

Michael Girardot , Ryutaro Hirasawa , Salim Kacem , L. Fritsch , J. Pontis et al.
Nucleic Acids Research, 2014, 42 (1), pp.235-248. ⟨10.1093/nar/gkt884⟩
Article dans une revue hal-02181362 v1
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Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase.

Yohan Soreze , Audrey Boutron , Florence Habarou , Christine Barnerias , Luc Nonnenmacher et al.
Orphanet Journal of Rare Diseases, 2013, 8 (1), pp.192. ⟨10.1186/1750-1172-8-192⟩
Article dans une revue inserm-00938361 v1

The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation

C. Paul , C. Sardet , E. Fabbrizio
Cell Death and Differentiation, 2012, 19 (5), pp.900--8. ⟨10.1038/cdd.2011.193⟩
Article dans une revue hal-02193071 v1
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E4F1 connects the Bmi1-ARF-p53 pathway to epidermal stem cell-dependent skin homeostasis.

Julie Caramel , Matthieu Lacroix , Laurent Le Cam , Claude Sardet
Cell Cycle, 2011, 10 (6), pp.866-7. ⟨10.4161/cc.10.6.14974⟩
Article dans une revue inserm-00610180 v1
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E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.

Elodie Hatchi , Genevieve Rodier , Matthieu Lacroix , Julie Caramel , Olivier Kirsh et al.
Journal of Experimental Medicine, 2011, 208 (7), pp.1403-17. ⟨10.1084/jem.20101995⟩
Article dans une revue inserm-00610191 v1
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E4F1 dysfunction results in autophagic cell death in myeloid leukemic cells.

Elodie Hatchi , Laurent Le Cam , Geneviève Rodier , Claude Sardet
Autophagy, 2011, 7 (12), pp.1566-7. ⟨10.4161/auto.7.12.17991⟩
Article dans une revue inserm-00646349 v1

XIAP-associated factor 1 interacts with and attenuates the trans-activity of four and a Half LIM protein 2

V. P. Tan , C. S. Lam , J. Wang , B. C. Wong , W. Zhang et al.
Molecular Carcinogenesis, 2011, 50 (3), pp.199--207. ⟨10.1002/mc.20705⟩
Article dans une revue istex hal-02193331 v1

Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1

W. Zhang , J. Wang , B. Zou , C. Sardet , J. Li et al.
European Journal of Cancer, 2011, 47 (1), pp.121--30. ⟨10.1016/j.ejca.2010.07.045⟩
Article dans une revue istex hal-02193500 v1

E4F1 deficiency results in oxidative stress–mediated cell death of leukemic cells

Elodie Hatchi , Genevieve Rodier , Matthieu Lacroix , Julie Caramel , Olivier Kirsh et al.
Journal of Experimental Medicine, 2011, 208 (7), pp.1403-1417. ⟨10.1084/jem.20101995⟩
Article dans une revue hal-04766837 v1
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Dual mechanism controls asymmetric spindle position in ascidian germ cell precursors

F. Prodon , J. Chenevert , C. Hebras , R. Dumollard , E. Faure et al.
Development (Cambridge, England), 2010, 137 (12), pp.2011-2021. ⟨10.1242/dev.047845⟩
Article dans une revue hal-03025982 v1
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Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis.

Matthieu Lacroix , Julie Caramel , Perrine Goguet-Rubio , Laetitia K. Linares , Soline Estrach et al.
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (49), pp.21076-81. ⟨10.1073/pnas.1010167107⟩
Article dans une revue inserm-00555585 v1

Lessons from interconnected ubiquitylation and acetylation of p53: think metastable networks

Monsef Benkirane , Claude Sardet , O. Coux
Biochemical Society Transactions, 2010, 38 (Pt 1), pp.98-103. ⟨10.1042/BST0380098⟩
Article dans une revue hal-00450665 v1
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Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice.

Vanessa Fritz , Zohra Benfodda , Geneviève Rodier , Corinne Henriquet , François Iborra et al.
Molecular Cancer Therapeutics, 2010, 9 (6), pp.1740-54. ⟨10.1158/1535-7163.MCT-09-1064⟩
Article dans une revue inserm-00544679 v1

The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells

M. Tardat , J. Brustel , O. Kirsh , C. Lefevbre , M. Callanan et al.
Nature Cell Biology, 2010, 12 (11), pp.1086--93. ⟨10.1038/ncb2113⟩
Article dans une revue istex hal-02193626 v1

Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer

W. Zhang , B. Jiang , Z. Guo , C. Sardet , B. Zou et al.
Carcinogenesis, 2010, 31 (7), pp.1220--9. ⟨10.1093/carcin/bgq094⟩
Article dans une revue hal-02193632 v1
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The CDK4-pRB-E2F1 pathway controls insulin secretion.

Jean-Sébastien Annicotte , Emilie Blanchet , Carine Chavey , Irena Iankova , Safia Costes et al.
Nature Cell Biology, 2009, 11 (8), pp.1017-23. ⟨10.1038/ncb1915⟩
Article dans une revue inserm-00418907 v1

PR‐SET7 and SUV4‐20H regulate H4 lysine‐20 methylation at imprinting control regions in the mouse

Maëlle Pannetier , Eric Julien , Gunnar Schotta , Mathieu Tardat , Claude Sardet et al.
EMBO Reports, 2008, 9 (10), pp.998-1005. ⟨10.1038/embor.2008.147⟩
Article dans une revue hal-02534254 v1

The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5.

Matthieu Lacroix , Selma El Messaoudi , Geneviève Rodier , Aphonse Le Cam , Claude Sardet et al.
EMBO Reports, 2008, 9 (5), pp.452-8. ⟨10.1038/embor.2008.45⟩
Article dans une revue hal-00353700 v1

Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene.

Selma El Messaoudi , Eric Fabbrizio , Carmen Rodriguez , Paul Chuchana , Lucas Fauquier et al.
Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (36), pp.13351-6. ⟨10.1073/pnas.0605692103⟩
Article dans une revue hal-00169734 v1

E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation

L. Le Cam , L. K. Linares , C. Paul , E. Julien , M. Lacroix et al.
Cell, 2006, 127 (4), pp.775--88. ⟨10.1016/j.cell.2006.09.031⟩
Article dans une revue hal-02262465 v1

The LIM-only protein FHL2 is a negative regulator of E4F1

C. Paul , M. Lacroix , I. Iankova , E. Julien , B. W. Schafer et al.
Oncogene, 2006, 25 (40), pp.5475--84. ⟨10.1038/sj.onc.1209567⟩
Article dans une revue hal-02262467 v1
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A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner

C. Attwooll , S. Oddi , P. Cartwright , E. Prosperini , K. Agger et al.
Journal of Biological Chemistry, 2005, 280 (2), pp.1199-1208. ⟨10.1074/jbc.M412509200⟩
Article dans une revue hal-02262247 v1

A map of the interactome network of the metazoan C-elegans

S. M. Li , C. M. Armstrong , N. Bertin , H. Ge , S. Milstein et al.
Science, 2004, 303 (5657), pp.540--543. ⟨10.1126/science.1091403⟩
Article dans une revue hal-02262415 v1

Identification of the E1A-regulated transcription factor p120(E4F) as an interacting partner of the RASSF1A candidate tumor suppressor gene

S. L. Fenton , A. Dallol , A. Agathanggelou , L. Hesson , J. Ahmed-Choudhury et al.
Cancer Research, 2004, 64 (1), pp.102--107. ⟨10.1158/0008-5472.CAN-03-2622⟩
Article dans une revue hal-02262407 v1

The E4F protein is required for mitotic progression during embryonic cell cycles

L. Le Cam , M. Lacroix , M. A. Ciemerych , C. Sardet , P. Sicinski
Molecular and Cellular Biology, 2004, 24 (14), pp.6467--6475. ⟨10.1128/MCB.24.14.6467-6475.2004⟩
Article dans une revue hal-02262414 v1
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Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65

Rosemary Kiernan , V. Bres , Raymond W. M. Ng , M. P. Coudart , S. El Messaoudi et al.
Journal of Biological Chemistry, 2003, 278 (4), pp.2758-2766. ⟨10.1074/jbc.M209572200⟩
Article dans une revue hal-02239699 v1

Retinoblastoma protein transcriptional repression through histone deacetylation of a single nucleosome

A. J. Morrison , C. Sardet , R. E. Herrera
Molecular and Cellular Biology, 2002, 22 (3), pp.856--865. ⟨10.1128/MCB.22.3.856-865.2002⟩
Article dans une revue hal-02197535 v1

Negative regulation of transcription by the type II arginine methyltransferase PRMT5

E. Fabbrizio , S. El Messaoudi , J. Polanowska , C. Paul , J. R. Cook et al.
EMBO Reports, 2002, 3 (7), pp.641--645. ⟨10.1093/embo-reports/kvf136⟩
Article dans une revue hal-02197525 v1

E2Fs regulate adipocyte differentiation

L. Fajas , R. L. Landsberg , Y. Huss-Garcia , C. Sardet , J. A. Lees et al.
Developmental Cell, 2002, 3 (1), pp.39--49. ⟨10.1016/s1534-5807(02)00190-9⟩
Article dans une revue hal-02197526 v1
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A B-myb promoter corepressor site facilitates in vivo occupation of the adjacent E2F site by p107-E2F and p130-E2F complexes

S. Catchpole , F. Tavner , L. Le Cam , C. Sardet , R. J. Watson
Journal of Biological Chemistry, 2002, 277 (41), pp.39015-39024. ⟨10.1074/jbc.M202960200⟩
Article dans une revue hal-02197519 v1

Retinoblastoma gene proteins: sensors for proliferation signals

E. Fabbrizio , C. Sardet
Médecine/Sciences, 2001, 17 (6-7), pp.798--800. ⟨10.4267/10608/2057⟩
Article dans une revue hal-02197453 v1

Cyclin A is a mediator of p120E4F-dependent cell cycle arrest in G1

L. Fajas , C. Paul , A. Vié , S. Estrach , R. Medema et al.
Molecular and Cellular Biology, 2001, 21 (8), pp.2956--66. ⟨10.1128/mcb.21.8.2956-2966.2001⟩
Article dans une revue hal-02197307 v1

The periodic down regulation of Cyclin E gene expression from exit of mitosis to end of G(1) is controlled by a deacetylase- and E2F-associated bipartite repressor element

J. Polanowska , E. Fabbrizio , L. Le Cam , Didier Trouche , S. Emiliani et al.
Oncogene, 2001, 20 (31), pp.4115--27. ⟨10.1038/sj.onc.1204514⟩
Article dans une revue hal-02197312 v1

The retinoblastoma-like protein p130 is involved in the determination of reserve-cells in differentiating myoblasts

Gilles Carnac , L. Fajas , A. L'Honore , C. Sardet , N. J. C. Lamb et al.
Current Biology, 2000, 10 (9), pp.543--546. ⟨10.1016/S0960-9822(00)00471-1⟩
Article dans une revue hal-02196840 v1
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The Rac1-and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin

Jean-Michel Bellanger , Catherine Astier , Claude Sardet , Yasutaka Ohta , Thomas P. Stossel et al.
Nature Cell Biology, 2000, 2 (12), pp.888-892. ⟨10.1038/35046533⟩
Article dans une revue hal-02196838 v1
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Erythroid-specific inhibition of the tal-1 intragenic promoter is due to binding of a repressor to a novel silencer

C. Courtes , N. Lecointe , L. Le Cam , Fulbert Baudoin , C. Sardet et al.
Journal of Biological Chemistry, 2000, 275 (2), pp.949-958. ⟨10.1074/jbc.275.2.949⟩
Article dans une revue hal-02196811 v1

A CDE/CHR-like element mediates repression of transcription of the mouse RB2 (p130) gene

L. Fajas , L. Le Cam , J. Polanowska , E. Fabbrizio , N. Servant et al.
FEBS Letters, 2000, 471 (1), pp.29--33. ⟨10.1016/S0014-5793(00)01363-6⟩
Article dans une revue hal-02196816 v1

Human E2F5 gene is oncogenic in primary rodent cells and is amplified in human breast tumors

J. Polanowska , L. Le Cam , B. Orsetti , H. Valles , E. Fabbrizio et al.
Genes, Chromosomes & Cancer, 2000, 28 (1), pp.126--130. ⟨10.1002/(SICI)1098-2264(200005)28:1<126::AID-GCC15>3.0.CO;2-G⟩
Article dans une revue istex hal-02196851 v1

Cell cycle regulated expression of mammalian CDC6 is dependent on E2F

G. Hateboer , A. Wobst , B. O. Petersen , L. Le Cam , E. Vigo et al.
Molecular and Cellular Biology, 1998, 18 (11), pp.6679--6697
Article dans une revue hal-02195868 v1

Regulation of E2F-1 gene expression in avian cells.

X. Espanel , L. Le Cam , S. North , C. Sardet , Gilbert Brun et al.
Oncogene, 1998, 17, pp.585-594
Article dans une revue hal-00023710 v1

Activation of E2F-mediated transcription by human T-cell leukemia virus type I Tax protein in a p16(INK4A)-negative T-cell line.

I. Lemasson , S. Thébault , C. Sardet , C. Devaux , Jean-Michel Mesnard
Journal of Biological Chemistry, 1998, 273 (36), pp.23598-604
Article dans une revue hal-00189014 v1

Regulation of E2F-1 gene expression in avian cells.

X. Espanel , L. Lecam , S. North , C. Sardet , G. Brun et al.
Oncogene, 1998, 17, pp.585-594
Article dans une revue hal-00314332 v1