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Clément Campillo, MCF Laboratoire LAMBE (Université d'Evry Val d'Essonne, Université Paris Saclay)


Research activities

Since 2013: Assistant professor, Laboratoire d’Analyse et de Modélisation pour la Biologie et l’Environnement (LAMBE, UMR 8587, Evry), UEVE, Université Paris Saclay

Mechanics of cells probed by AFM (with J. Pelta, S. Labdi and B. Thiebot) [18]

Oocyte mechanics [15,16]

Biomimetic systems of the cell cortex [17,20-23].

 

Sept. 2017: « Habilitation à Diriger les Recherches », U. Paris-Saclay

« Studying and reconstituting the mechanics of the cell cortex »

 

2012-2013:Post-doc. Institut Lumière Matière, Lyon (supervisor: J-P. Rieu)

Impedance spectroscopy of cancer cells on microdevices (collaboration with R. Ferrigno, Institut des Nanotechnologies de Lyon and H. Mertani, Centre de Recherche en Cancérologie de Lyon).

 

June-sept. 2011: Visiting scientist, Gardel Lab, University of Chicago

Micropipette aspiration of Arp2/3 deficient cells [14].

 

2008-2012: Post-doc. Physico-Chimie Curie (PCC), Paris (supervisor C. Sykes)

Role of membrane inclusions and actin cortex on membrane rheology by membrane nanotube extrusion (collaboration with P. Nassoy, P. Bassereau and P. Sens) [12,13] 

Membrane-cytoskeleton interactions in ciliopathy (collaboration with P. Dupuis-Williams, ESPCI) [11]

Role of membrane tension in cell motility (collaboration with J. Plastino, PCC) [9]

Mechanics mouse oocytes (Collaboration with M-E. Terret & M-H Verlhac, CIRB, Collège de France) [14,16]

 

2004-2007: PhD SPrAM - CEA Grenoble (supervisors B. Pépin-Donat & A. Viallat)

“Development of thermo-responsive vesicles from polyNipam systems” [1,2,8,9,19]

Membrane mechanics of composite vesicles (collaboration with F. Brochard-Wyart, PCC) [3,6]

Mechanics of composite vesicles (Visiting student in Institut Charles Sadron, Strasbourg, France, 6 months) [4,5]

 

Reviewer for Nature Communications, Soft Matter, RSC Advances, ACS Omega, Biophysical Journal, New Journal of Physics, PLOS One, Physical Biology (Outstanding Reviewer award for 2018), Biomedical Physics & Engineering Express (IOP), Measurement Science and Technology (IOP)

 

Member of GDR CellTiss

 

Grants & Fellowships

 

2018 Coordinator of “High Throughput AFM”, fellowship from DIM Respore/UEVE, 82 k€ 

2018 – 2021 Coordinator of “Dynactube”, ANR JCJC (young researcher fellowship, french National Research Agency), 317 k€

2016 Partner of project AFM-UEVE, grant from region Ile de France (Sesame mi-lourd, DIM NanoK), 126 k€ (supplemented by UEVE 70 k€)

2015-2016Teaching duty reduction (96h) from “Fonds de Rayonnement de la Recherche”, UEVE

2008-2012Postdoctoral fellowship from french Cancer Research Association

2004-2007PhD fellowship from International Research Training Group Grenoble-Strasbourg-Konstanz

 

Supervision

 

PhDs & Postdocs

 

R. Lopes Dos Santos, PhD candidateon the remodelling of membrane nanotubes, from february 2019

M. Liboz, PhD candidateon the mechanics of micropatterned cancer cells, from september 2018

G. Lamour, postdoc (two years fellowship from Genopole, Evry), on the study of membrane nanotubes by AFM, from september 2016

A. Allard, PhD candidate, co-supervised by C. Sykes (PCC) and S. Labdi (LAMBE), on the effect of actin polymerization on membrane nanotubes stability [21,23], from january 2016

F. Valentino, PhD defended on September 27th2016, co-supervised since 2014 with C. Sykes (PCC), on actin polymerization on membrane nanotubes [20,21]. Now research and development engineer at Phasics (Saclay).

 

Undergraduate students

 

M. Liboz, Master 2 MAVINOV, U. Paris-Saclay, 4 months, 2018 

C. Colne, Licence 3 Chemistry, UEVE, 3 weeks, 2018

T. Groux, Master 1 Chemistry, UEVE, 3 months, 2017 

S. Brahimi, Licence 3 Chemistry, UEVE, 3 weeks, 2017

W. Hao, Licence Physique UCBL/ Wuhan University (China), 2 months, 2013

R. Pereira, Master Physical Engineering of Health, Paris 5, 2 months, 2011

G. Guiot, Ecole Polytechnique, 1st year, 3 months, 2010

L. Claverie, Ecole Polytechnique, 1st year, 3 months, 2009

F. Quémeneur, Master « Physics for life sciences», UJF, 4 months, 2005

 

 

Communications

 

 

Oral presentations

 

Biomaterials Workshop (Invited talk), DIM Respore, Paris, 2019

Shapes in chemistry and biologyWorkshop, IPREM, Pau, 2017

“Active & Smart Matter Conference”, Syracuse, USA, 2016

Invited Seminar, LNIO, UTT, Troyes, France 2016

Invited Seminar, LADHYX, Ecole Polytechnique, Palaiseau, France 2015

Invited Seminar, LPSM, CEA Saclay 2015

GDR CellTiss, Mont Saint Odile, 2014

Invited Seminar, IMNC, Orsay 2014

Invited Seminar, Lenne Lab, IBDML, Luminy 2013

Invited Seminar, Baigl Lab, ENS Paris 2013

Invited Seminar, ITAV, Toulouse 2012

Invited Seminar, LPMCN, Lyon 2011

Invited Seminars, Gardel Lab, Lee Lab, University of Chicago, USA 2011

Invited Seminar, LADHYX, Ecole Polytechnique, Palaiseau, France 2010

Invited Seminar, Laboratoire de Spectrométrie Physique, Grenoble, 2010

GDR CellTiss, Gif-sur-Yvette, 2009

Softcomp Annual Meeting, Venice, Italy, 2009

12th Young Researchers & Life Sciences meeting, Paris, 2009

Biophysical Society 53rd Annual Meeting, Boston, USA, 3 mars 2009

Invited Seminar, SprAM, CEA-Grenoble, 2008

Softcomp Annual Meeting, Riva del Garda, Italy, 2008

Invited Seminar, Laboratoire de Spectrométrie Physique, Grenoble,2007 

Invited Seminar, Institut Charles Sadron, Strasbourg, 2007

Invited Seminar, Spatz group, Max Planck Institut Stuttgart, Germany 2007

Congrès de la Société Française de Physique, Grenoble 2007

Invited Seminar, Institut Curie, Paris, 2007

Congrès Français de Mécanique, Troyes,2005

Meeting of the German Colloid Society, Aachen, Germany2005

 

 

Poster presentations

 

Membrane Biophysics of Exo-Endocytosis: from Model Systems to Cells” conference, Mandelieu 2019

“International Soft Matter Conference”, Grenoble 2016

“Physics & Biological Systems” conference, Gif-sur-Yvette 2014

FPGG Spring Symposium, 2011

Biophysical Society Conference “Actin, Cytoskeleton and Nucleus”, Singapore, 2010

“International Soft Matter Conference”, Granada, Spain, 2010

Pierre-Gilles de Gennes Winter School, Cargese, 2008

“Fundamental and Applied Macromolecular Science”, Strasbourg 2007


Journal articles31 documents

  • Yassir Lemseffer, Marie-Emilie Terret, Clément Campillo, Elsa Labrune. Methods for Assessing Oocyte Quality: A Review of Literature. Biomedicines, 2022, 10 (9), pp.2184. ⟨10.3390/biomedicines10092184⟩. ⟨hal-03811993⟩
  • Antoine Allard, Rogério Lopes dos Santos, Clément Campillo. Remodelling of membrane tubules by the actin cytoskeleton. Biology of the Cell, 2021, 113 (8), pp.329-343. ⟨10.1111/boc.202000148⟩. ⟨hal-03641979⟩
  • A. Allard, F. Valentino, C. Sykes, T. Betz, C. Campillo. Fluctuations of a membrane nanotube covered with an actin sleeve. Physical Review E , 2020, 102 (5), pp.052402. ⟨10.1103/PhysRevE.102.052402⟩. ⟨hal-03014749⟩
  • A. Allard, M. Bouzid, T. Betz, C. Simon, M. Abou-Ghali, et al.. Actin modulates shape and mechanics of tubular membranes. Science Advances , 2020, 6 (17), pp.eaaz3050. ⟨10.1126/sciadv.aaz3050⟩. ⟨hal-02565199⟩
  • Isma Bennabi, Flora Crozet, Elvira Nikalayevich, Agathe Chaigne, Gaëlle Letort, et al.. Artificially decreasing cortical tension generates aneuploidy in mouse oocytes. Nature Communications, 2020, 11, ⟨10.1038/s41467-020-15470-y⟩. ⟨hal-03003434⟩
  • Guillaume Lamour, Antoine Allard, Juan Pelta, Sid Labdi, Martin Lenz, et al.. Mapping and Modeling the Nanomechanics of Bare and Protein-Coated Lipid Nanotubes. Physical Review X, 2020, 10 (1), pp.011031. ⟨10.1103/PhysRevX.10.011031⟩. ⟨hal-02512272⟩
  • Camille Simon, Remy Kusters, Valentina Caorsi, Antoine Allard, Majdouline Abou-Ghali, et al.. Actin dynamics drive cell-like membrane deformation. Nature Physics, 2019, 15 (6), pp.602-609. ⟨10.1038/s41567-019-0464-1⟩. ⟨hal-02895971⟩
  • Camille Chane Simon, Valentina Caorsi, Clément Campillo, C. Sykes. Interplay between membrane tension and the actin cytoskeleton determines shape changes. Physical Biology, 2018, 15 (6), pp.065004. ⟨10.1088/1478-3975/aad1ab⟩. ⟨hal-01980544⟩
  • F. Valentino, Pierre Sens, J. Lemière, A. Allard, T. Betz, et al.. Fluctuations of a membrane nanotube revealed by high-resolution force measurements. Soft Matter, 2016, 12 (47), pp.9429 - 9435. ⟨10.1039/c6sm02117d⟩. ⟨hal-01411519⟩
  • J. Lemière, F. Valentino, C. Campillo, C. Sykes. How cellular membrane properties are affected by the actin cytoskeleton. Biochimie, 2016, 130, pp.33-40. ⟨10.1016/j.biochi.2016.09.019⟩. ⟨hal-02065240⟩
  • Agathe Chaigne, Clément Campillo, Raphaël Voituriez, Nir S. Gov, C. Sykes, et al.. F-actin mechanics control spindle centring in the mouse zygote. Nature Communications, 2016, 7, pp.10253. ⟨10.1038/ncomms10253⟩. ⟨hal-01276390⟩
  • Valentina Caorsi, Wu Sangsong, Joël Lemiere, Clément Campillo, Timo Betz, et al.. How Synergy of Actin Assembly-Disassembly and Myosin Motors Drives Cell Shape Changes. Biophysical Journal, 2016, 110 (3), pp.127a-128a. ⟨10.1016/j.bpj.2015.11.732⟩. ⟨hal-02065242⟩
  • V. Caorsi, J. Lemière, Clément Campillo, M. Bussonnier, J. Manzi, et al.. Cell-sized liposome doublets reveal active tension build-up driven by acto-myosin dynamics. Soft Matter, 2016, 12 (29), pp.6223-6231. ⟨10.1039/C6SM00856A⟩. ⟨hal-02065261⟩
  • Georges Smolyakov, Bénédicte Thiebot, Clément Campillo, Sid Labdi, Childérick Séverac, et al.. Elasticity, Adhesion, and Tether Extrusion on Breast Cancer Cells Provide a Signature of Their Invasive Potential. ACS Applied Materials & Interfaces, 2016, 8 (41), pp.27426 - 27431. ⟨10.1021/acsami.6b07698⟩. ⟨hal-01552762⟩
  • Agathe Chaigne, Clément Campillo, Nir S Gov, Raphaël Voituriez, C. Sykes, et al.. A narrow window of cortical tension guides asymmetric spindle positioning in the mouse oocyte. Nature Communications, 2015, 6 (1), pp.6027. ⟨10.1038/ncomms7027⟩. ⟨hal-02065107⟩
  • Yvonne Beckham, Robert J Vasquez, Jonathan Stricker, Kareem Sayegh, Clément Campillo, et al.. Arp2/3 Inhibition Induces Amoeboid-Like Protrusions in MCF10A Epithelial Cells by Reduced Cytoskeletal-Membrane Coupling and Focal Adhesion Assembly. PLoS ONE, 2014, 9 (6), pp.e100943. ⟨10.1371/journal.pone.0100943⟩. ⟨hal-02148251⟩
  • Clément Campillo, Pierre Sens, Darius Koester, Lea-Laetitia Pontani, Daniel Lévy, et al.. Unexpected Membrane Dynamics Unveiled by Membrane Nanotube Extrusion. Biophysical Journal, 2013, 104 (6), pp.1248-1256. ⟨10.1016/j.bpj.2013.01.051⟩. ⟨hal-00821323⟩
  • Clément Campillo, Pierre Sens, Darius Köster, Lea-Laetitia Pontani, Daniel Lévy, et al.. Unexpected Membrane Dynamics Unveiled by Membrane Nanotube Extrusion. Biophysical Journal, 2013, 104 (6), pp.1248-1256. ⟨10.1016/j.bpj.2013.01.051⟩. ⟨hal-02896076⟩
  • Joel Lemiere, Karine Guevorkian, Clément Campillo, C. Sykes, Timo Betz. α-Hemolysin membrane pore density measured on liposomes. Soft Matter, 2013, 9, pp.3181-3187. ⟨10.1039/c3sm27812c⟩. ⟨hal-01319268⟩
  • Agathe Chaigne, Clément Campillo, Nir S. Gov, Raphael Voituriez, Jessica Azoury, et al.. A soft cortex is essential for asymmetric spindle positioning in mouse oocytes. Nature Cell Biology, 2013, 15 (8), pp.958-966. ⟨10.1038/ncb2799⟩. ⟨hal-00994646⟩
  • Clément Campillo, Julie Jerber, Cathy Fisch, Maria Simoes-Betbeder, Pascale Dupuis-Williams, et al.. Mechanics of membrane-cytoskeleton attachment in Paramecium. New Journal of Physics, 2012, 14, 125016, 9 p. ⟨10.1088/1367-2630/14/12/125016⟩. ⟨hal-00814768⟩
  • E. Batchelder, G. Hollopeter, C. Campillo, X. Mezanges, E. Jorgensen, et al.. Membrane tension regulates motility by controlling lamellipodium organization. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (28), pp.11429-11434. ⟨10.1073/pnas.1010481108⟩. ⟨hal-02896087⟩
  • Ellen L. Batchelder, Gunther Hollopeter, Clément Campillo, Xavier Mezanges, Erik M. Jorgensen, et al.. Membrane tension regulates motility by controlling lamellipodium organization. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (28), pp.11429-11434. ⟨10.1073/pnas.1010481108⟩. ⟨hal-00814820⟩
  • Stéphane Kremer, C. Campillo, F. Quemeneur, M. Rinaudo, B. Pepin-Donat, et al.. Nanotubes from asymmetrically decorated vesicles. Soft Matter, 2011, pp.946-951. ⟨hal-00577118⟩
  • Brigitte Pepin-Donat, Clément Campillo, François Quemeneur, Marguerite Rinaudo, Carlos Marques, et al.. Lipidic composite vesicles based on poly(NIPAM), chitosan or hyaluronan: behaviour under stresses. International Journal of Nano Dimension, 2011, 2 (1), pp.17-23. ⟨10.7508/IJND.2011.01.002⟩. ⟨hal-02148160⟩
  • C.C. Campillo, A.P. Schroder, C.M. Marques, B. Pepin-Donat. Composite gel-filled giant vesicles : Membrane homogeneity and mechanical properties. Materials Science and Engineering: C, 2009, 29 (2), pp.393-397. ⟨hal-00430699⟩
  • C. C. Campillo, A. P. Schroder, C. M. Marques, B. Pepin-Donat. Volume transition in composite poly(NIPAM)-giant unilamellar vesicles. Soft Matter, 2008, 4 (12), pp.2486-2491. ⟨hal-00359009⟩
  • Annie Viallat, Clément Campillo, Brigitte Pepin-Donat, Françoise Brochard-Wyart, Sebastien Kremer. Nanotubes from gelly vesicles. EPL - Europhysics Letters, 2008, 82, pp.48002. ⟨10.1209/0295-5075/82/48002⟩. ⟨hal-00351648⟩
  • S. Kremer, Clément Campillo, B. Pepin-Donat, A. Viallat, F. Brochard-Wyart. Nanotubes from gelly vesicles. EPL - Europhysics Letters, 2008, 82 (4), pp.48002. ⟨10.1209/0295-5075/82/48002⟩. ⟨hal-02148071⟩
  • Clément Campillo, Brigitte Pepin-Donat, Annie Viallat. Responsive viscoelastic giant lipid vesicles filled with a poly(N-isopropylacrylamide) artificial cytoskeleton. Soft Matter, 2007, 3 (11), pp.1421. ⟨10.1039/B710474J⟩. ⟨hal-01957761⟩
  • Magalie Faivre, Clément Campillo, B. Pepin-Donat, Annie Viallat. Responsive Giant Vesicles filled with Poly(N-isopropylacrylamide) Sols or Gels. Progress in Colloid and Polymer Science, 2006, 133, pp.41. ⟨10.1007/2882_050⟩. ⟨hal-00321709⟩

Conference papers1 document

  • Agathe Chaigne, Clément Campillo, Jessica Azoury, Claudia Umana-Diaz, Pierre Nassoy, et al.. Characterization of a novel subcortical actin layer regulating spindle positioning and cortical plasticity in mouse oocytes. Annual Meeting of the American-Society-for-Cell-Biology (ASCB), Dec 2011, Denver, United States. pp.85. ⟨hal-00995023⟩

Book sections1 document

  • B. Pepin-Donat, F. Quemeneur, M. Rinaudo, C. Campillo. Capsules based on lipid vesicles: potentiality for drug delivery. Nanomedicine and drug delivery, Academic Press, pp.139-153, 2012. ⟨hal-00849891⟩

Theses1 document

  • Clément Campillo. Développement et étude d'objets biomimétiques stimulables : Vésicules géantes encapsulant des systèmes visco-élastiques de poly(NIPAM). Analyse de données, Statistiques et Probabilités [physics.data-an]. Université Joseph-Fourier - Grenoble I, 2008. Français. ⟨NNT : ⟩. ⟨tel-00432264⟩