Eric Leclerc

46
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Publications

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Transcriptomic profiling analysis of the effect of palmitic acid on 3D spheroids of β-like cells derived from induced pluripotent stem cells

Lisa Morisseau , Fumiya Tokito , Mathilde Lucas , Stéphane Poulain , Soo Hyeon Kim et al.
Gene, 2024, 917, pp.148441. ⟨10.1016/j.gene.2024.148441⟩
Article dans une revue hal-04608624 v1
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Dynamic, IPSC-derived hepatic tissue tri-culture system for the evaluation of liver physiology in vitro

Benedikt Scheidecker , Stéphane Poulain , Masahiro Sugimoto , Taketomo Kido , Takumi Kawanishi et al.
Biofabrication, 2024, 16 (2), pp.025037. ⟨10.1088/1758-5090/ad30c5⟩
Article dans une revue hal-04749333 v1

Investigation of the motif activity of transcription regulators in pancreatic β-like cell subpopulations differentiated from human induced pluripotent stem cells

Eric Leclerc , Mikhail Pachkov , Lisa Morisseau , Fumiya Tokito , Cecile Legallais et al.
Molecular Omics, 2024, ⟨10.1039/D4MO00082J⟩
Article dans une revue hal-04787625 v1
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Transcriptomic and proteomic studies suggest the establishment of advanced zonation‐like profiles in human‐induced pluripotent stem cell‐derived liver sinusoidal endothelial cells and carboxypeptidase M‐positive liver progenitor cells cocultured in a fluidic microenvironment

Mathieu Danoy , Stéphane Poulain , Rachid Jellali , Benedikt Scheidecker , Yannick Tauran et al.
Hepatology Research, 2023, 53 (7), pp.661-674. ⟨10.1111/hepr.13893⟩
Article dans une revue hal-04749331 v1
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Generation of β-like cell subtypes from differentiated human induced pluripotent stem cells in 3D spheroids

Lisa Morisseau , Fumiya Tokito , Stéphane Poulain , Valérie Plaisance , Valerie Pawlowski et al.
Molecular Omics, 2023, 19 (10), pp.810-822. ⟨10.1039/D3MO00050H⟩
Article dans une revue hal-04209565 v1
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Analysis of the transcriptome and metabolome of pancreatic spheroids derived from human induced pluripotent stem cells and matured in an organ-on-a-chip

Amal Essaouiba , Rachid Jellali , Stéphane Poulain , Fumiya Tokito , Françoise Gilard et al.
Molecular Omics, 2022, 18 (8), pp.791-804. ⟨10.1039/d2mo00132b⟩
Article dans une revue hal-03861419 v1

A novel agonist for the HGF receptor MET promotes differentiation of human pluripotent stem cells into hepatocyte-like cells

Yannick Tauran , Lereau-Bernier Myriam , Segard Bertrand David , Danoy Mathieu , Kimura Keiichi et al.
Development, growth & differentiation., 2022, 64 (9), pp.527-536
Article dans une revue hal-04817909 v1
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Liver organ-on-chip models for toxicity studies and risk assessment

Taha Messelmani , Lisa Morisseau , Yasuyuki Sakai , Cécile Legallais , Anne Le Goff et al.
Lab on a Chip, 2022, 22 (13), pp.2423-2450. ⟨10.1039/d2lc00307d⟩
Article dans une revue hal-03861401 v1

A novel agonist for the HGF receptor MET promotes differentiation of human pluripotent stem cells into hepatocyte‐like cells

Yannick Tauran , Myriam Lereau-Bernier , Bertrand David Segard , Mathieu Danoy , Keiichi Kimura et al.
Development, Growth and Differentiation, 2022, 64 (9), pp.527-536. ⟨10.1111/dgd.12818⟩
Article dans une revue hal-04279694 v1
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Multi‐omics analysis of hiPSCs‐derived HLCs matured on‐chip revealed patterns typical of liver regeneration

Mathieu Danoy , Yannick Tauran , Stéphane Poulain , Rachid Jellali , Johanna Bruce et al.
Biotechnology and Bioengineering, In press, ⟨10.1002/bit.27667⟩
Article dans une revue hal-03288795 v1

Investigation of the hepatic development in the coculture of hiPSCs-derived LSECs and HLCs in a fluidic microenvironment

Mathieu Danoy , Yannick Tauran , Stephane Poulain , Rachid Jellali , Johanna Bruce et al.
APL Bioengineering, 2021, 5 (2), ⟨10.1063/5.0041227⟩
Article dans une revue hal-03286327 v1
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Analysis of the behavior of 2D monolayers and 3D spheroid human pancreatic beta cells derived from induced pluripotent stem cells in a microfluidic environment

Amal Essaouiba , Rachid Jellali , Marie Shinohara , Benedikt Scheidecker , Cécile Legallais et al.
Journal of Biotechnology, 2021, 330, pp.45-56. ⟨10.1016/j.jbiotec.2021.02.009⟩
Article dans une revue hal-03285819 v1
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Characterization of the proteome and metabolome of human liver sinusoidal endothelial-like cells derived from induced pluripotent stem cells

Mathieu Danoy , Rachid Jellali , Yannick Tauran , Johanna Bruce , Marjorie Leduc et al.
Differentiation, 2021, 120, pp.1-26. ⟨10.1016/j.diff.2021.06.001⟩
Article dans une revue hal-03288696 v1
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Metabolomic profiling during the differentiation of human induced pluripotent stem cells into hepatocyte-like cells

Rachid Jellali , Myriam Lereau Bernier , Yannick Tauran , Françoise Gilard , Mathieu Danoy et al.
Differentiation, 2020, 112, pp.17-26. ⟨10.1016/j.diff.2019.10.006⟩
Article dans une revue hal-02453731 v1
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Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies

Amal Essaouiba , Teru Okitsu , R. Kinoshita , Rachid Jellali , Yasuyuki Sakai et al.
Biochemical Engineering Journal, 2020, 164, pp.107783. ⟨10.1016/j.bej.2020.107783⟩
Article dans une revue hal-03095499 v1

Optimized protocol for the hepatic differentiation of induced pluripotent stem cells in a fluidic microenvironment

Mathieu Danoy , Myriam Lereau Bernier , Keiichi Kimura , Stéphane Poulain , Sachi Kato et al.
Biotechnology and Bioengineering, 2019, 116 (7), pp.1762-1776. ⟨10.1002/bit.26970⟩
Article dans une revue hal-02357453 v1
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Analysis of the transcription factors and their regulatory roles during a step-by-step differentiation of induced pluripotent stem cells into hepatocyte-like cells

Yannick Y. Tauran , Stéphane Poulain , Myriam Lereau-Bernier , Mathieu Danoy , Marie Shinohara et al.
Molecular Omics, 2019, ⟨10.1039/C9MO00122K⟩
Article dans une revue hal-02357458 v1

Profiling of derived-hepatocyte progenitors from induced pluripotent stem cells using nanoCAGE promoter analysis

Myriam Lereau Bernier , Stéphane Poulain , Yannick Y. Tauran , Mathieu Danoy , Marie Shinohara et al.
Biochemical Engineering Journal, 2019, 142, pp.7-17. ⟨10.1016/j.bej.2018.11.001⟩
Article dans une revue hal-02357456 v1
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Integration of metabolomic and transcriptomic profiling to compare two protocols of differentiation of human induced pluripotent stem cells into hepatocytes

Rachid Jellali , Stéphane Poulain , Myriam Lereau Bernier , Françoise Gilard , Yannick Y. Tauran et al.
Process Biochemistry, 2019, 88, pp.139-147. ⟨10.1016/j.procbio.2019.09.034⟩
Article dans une revue hal-02357452 v1

Simplest Chemosensor Array for Phosphorylated Saccharides

Yui Sasaki , Eric Leclerc , Vahid Hamedpour , Riku Kubota , Shin-Ya Takizawa et al.
Analytical Chemistry, 2019, ⟨10.1021/acs.analchem.9b03578⟩
Article dans une revue hal-02369560 v1

Investigation of the hepatic respiration and liver zonation on rat hepatocytes using an integrated oxygen biosensor in a microscale device

Satomi Matsumoto , Astia Safitri , Mathieu Danoy , Toshiro Maekawa , Haruyuki Kinoshita et al.
Biotechnology Progress, 2019, 35 (5), ⟨10.1002/btpr.2854⟩
Article dans une revue hal-02357455 v1

Integration of an oxygen sensor into a polydymethylsiloxane hepatic culture device for two-dimensional gradient characterization

Satomi Matsumoto , Eric Leclerc , Toshiro Maekawa , Haruyuki Kinoshita , Marie Shinohara et al.
Sensors and Actuators B: Chemical, 2018, 273, pp.1062-1069. ⟨10.1016/j.snb.2018.05.053⟩
Article dans une revue hal-02357459 v1

Metabolomics-on-a-chip approach to study hepatotoxicity of DDT, permethrin and their mixtures

Rachid Jellali , Françoise Gilard , Vittoria Pandolfi , Audrey Legendre , Marie-José Fleury et al.
Journal of Applied Toxicology, 2018, 38 (8), pp.1121-1134. ⟨10.1002/jat.3624⟩
Article dans une revue hal-02357461 v1
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Effects of DDT and permethrin on rat hepatocytes cultivated in microfluidic biochips: Metabolomics and gene expression study

Rachid Jellali , Perrine Zeller , Françoise Gilard , Audrey Legendre , Marie José Fleury et al.
Environmental Toxicology and Pharmacology, 2018, 59, pp.1-12. ⟨10.1016/j.etap.2018.02.004⟩
Article dans une revue hal-02357463 v1

Water-in-oil droplet formation in a flow-focusing microsystem using pressure- and flow rate-driven pumps

Sarah Lignel , Anne-Virginie Salsac , Audrey Drelich , Eric Leclerc , Isabelle Pezron
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2017, 531, pp.164-172. ⟨10.1016/j.colsurfa.2017.07.065⟩
Article dans une revue hal-02357482 v1

Online monitoring of hepatic rat metabolism by coupling a liver biochip and a mass spectrometer

Franck Merlier , Rachid Jellali , Eric Leclerc
Analyst, 2017, 142 (19), pp.3747-3757. ⟨10.1039/C7AN00973A⟩
Article dans une revue hal-01988812 v1

In vitro cyto-biocompatibility study of thin-film transistors substrates using an organotypic culture method

Eric Leclerc , Jean-Luc Duval , Christophe Egles , Satoshi Ihida , Hiroshi Toshiyoshi et al.
Journal of Materials Science: Materials in Medicine, 2017, 28 (1), pp.4. ⟨10.1007/s10856-016-5815-1⟩
Article dans une revue hal-01955190 v1

Thin-film-transistor array: an exploratory attempt for high throughput cell manipulation using electrowetting principle

F Azam Shaik , G Cathcart , S Ihida , M Lereau-Bernier , Eric Leclerc et al.
Journal of Micromechanics and Microengineering, 2017, 27 (5), pp.054001. ⟨10.1088/1361-6439/aa66e8⟩
Article dans une revue hal-02357490 v1

Transient behavior and relaxation of microcapsules with a cross-linked human serum albumin membrane

Pierre-Yves Gires , Dominique Barthès-Biesel , Eric Leclerc , Anne-Virginie Salsac
Journal of the mechanical behavior of biomedical materials, 2016, 58, pp.2-10. ⟨10.1016/j.jmbbm.2015.09.008⟩
Article dans une revue hal-02019566 v1

Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips

Régis Baudoin , Jean-Matthieu Prot , Grégory Nicolas , Jessy Brocheton , Céline Brochot et al.
Xenobiotica, 2013, 43 (2), pp.140-152. ⟨10.3109/00498254.2012.706725⟩
Article dans une revue ineris-00963431 v1

Microfluidic technique for measuring microcapsules.

Anne-Virginie Salsac , Eric Leclerc , Dominique Barthès-Biesel
Bioencapsulation Innovations, 2013
Article dans une revue hal-02019778 v1

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.

Leila Choucha-Snouber , Caroline Aninat , Laurent Grsicom , Geoffrey Madalinski , Céline Brochot et al.
Biotechnology and Bioengineering, 2013, 110 (2), pp.597-608. ⟨10.1002/bit.24707⟩
Article dans une revue istex inserm-00864839 v1
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Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: Application to acetaminophen injury

Jean-Matthieu Prot , Andrei Bunescu , Bénédicte Elena-Herrmann , Caroline Aninat , Leila Choucha Snouber et al.
Toxicology and Applied Pharmacology, 2012, 259 (3), pp.270-280. ⟨10.1016/j.taap.2011.12.017⟩
Article dans une revue hal-00699551 v1

Investigation of Oleic Acid, Palmitic Acid and their mixture on the development of hepatic steatosis using liver-on-chip technology

Lisa Morisseau , C. Legallais , Amar Abderrahmani , Yasuyoshi Sakai , Eric Leclerc et al.
49th ESAO Congress, Aug 2023, Bergamo, Italy
Communication dans un congrès hal-04476949 v1
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Contrôle découlement et suivi de prolifération dans des biopuces hépatiques

Taha Messelmani , Adam Meziane , William César , Marine Verhulsel , Zied Souguir et al.
25`eme Congrès Français de Mécanique, Aug 2022, Nantes, France
Communication dans un congrès hal-04497647 v1

Development of liver-on-chip model integrating LSEC barrier and hepatocytes organoids for toxicity application

Taha Messelmani , Anne Le Goff , Fabrice Soncin , Zied Souguir , Elodie Vandenhaute et al.
The 1st edition of the MicroPhysio conference on "Micro-physiological models: From organoids to organs-on-chip", Apr 2022, Cargese (Corse), France
Communication dans un congrès hal-04497703 v1

Development of an advanced liver organ-on-chip integrating hydroscaffold mimicking cell matrix

Taha Messelmani , Zied Souguir , Victoria Maes , Anne Le Goff , Elodie Vandenhaute et al.
47th ESAO Congress, Sep 2021, London (U.K.), United Kingdom
Communication dans un congrès hal-04497725 v1

3D liver-on-chip model integrating hydrogel mimicking cell matrix

Taha Messelmani , Zied Souguir , Victoria Maes , Anne Le Goff , Eric Leclerc et al.
TERMIS 6th World Congress, Nov 2021, Maastricht (Netherland), Netherlands
Communication dans un congrès hal-04500618 v1

Investigation of the Behavior of Rat Pancreatic Islets in an Organ-On-Chip Model

Amal Essaouiba , Teru Okitsu , Rachid Jellali , Marie Shinohara , Mathieu Danoy et al.
IFAO-JSAO Congress, Nov 2019, Osaka (JP), Japan
Communication dans un congrès hal-04475774 v1

Cryogel integrated microchip : towards a human 3D model of liver cancer

Lilandra Boulais , Rachid Jellali , Ulysse Pereira , Patrick Paullier , Eric Leclerc et al.
Cancer Cells-on-Chip 2, Mar 2019, Lyon, France
Communication dans un congrès hal-04475771 v1

Liver on chip platform: key questions following 15 years of development

C. Legallais , Rachid Jellali , Eric Leclerc
International MicroNanoconference, Dec 2018, Amsterdam, Netherlands
Communication dans un congrès hal-04475722 v1

Relation entre stabilité des émulsions eau-dans-huile et cristallisation de gouttes d’eau générées par microfluidique.

Audrey Drelich , Sarah Lignel , Danièle Clausse , Anne-Virginie Salsac , Eric Leclerc et al.
Journées de Calorimétrie et d’Analyse Thermique JAT 2017, May 2017, Rueil-Malmaison, France
Communication dans un congrès hal-02491826 v1

Pharmaco-metabonomic investigation of acetaminophen toxicity on rat primary hepatocytes in microfluidic biochips

Claire Lopez , Mathilde Bayet-Robert , Marc-Emmanuel Dumas , Jean-Matthieu Prot , Alexandre R.R. Pery et al.
7e Journées scientifiques du Réseau Français de Métabolomique et Fluxomique (RFMF), Jun 2013, Amiens, France
Communication dans un congrès hal-00980023 v1

Automatic evaluation of the elastic modulus of a capsule membrane

T.X. Chu , Anne-Virginie Salsac , Eric Leclerc , Dominique Barthès-Biesel
Knowledge and Systems Engineering. Advances in Intelligent Systems and Computing, 245, 2013, 978-3-319-02820-0. ⟨10.1007/978-3-319-02821-7_34⟩
Chapitre d'ouvrage hal-02019807 v1