Eric Leclerc

50
Documents

Publications

Publications

Deposit thumbnail

Identification of the differential and synergic lipotoxic patterns of oleic acid, palmitic acid, and their mixture in 3D HepG2/C3A tissue using liver‐on‐chip technology

Lisa Morisseau , Valérie Pawlowski , Valérie Plaisance , Mathilde Lucas , Cécile Legallais et al.

Biotechnology Progress, In press, ⟨10.1002/btpr.70075⟩

Article dans une revue hal-05318221v1
Deposit thumbnail

3D hepatic spheroids and liver‐organ on chip models displayed maintenance of hepatic functions and maturation profile in a long‐term culture of the humanized HepaSH cells, a human cell population harvested from chimeric mice

Hanyuan Wang , Carla Meschini , Stéphane Poulain , Soo Hyeon Kim , Hiroshi Arakawa et al.

Biotechnology Progress, 2025, ⟨10.1002/btpr.70043⟩

Article dans une revue (article de synthèse) hal-05109229v1
Deposit thumbnail

Computational modeling of the hepatocytes reveals new insights into alterations in drug metabolism, oxidative stress response, and glutathione detoxification in acetaminophen-induced hepatotoxicity associated with MASLD

Yuki Miura , Yasuyuki Sakai , Masaki Nishikawa , Eric Leclerc

Computational Toxicology, 2025, 36, pp.100384. ⟨10.1016/j.comtox.2025.100384⟩

Article dans une revue hal-05380695v1
Deposit thumbnail

Dynamic, IPSC-derived hepatic tissue tri-culture system for the evaluation of liver physiology in vitro

Benedikt Scheidecker , Stéphane Poulain , Masahiro Sugimoto , Taketomo Kido , Takumi Kawanishi et al.

Biofabrication, 2024, 16 (2), pp.025037. ⟨10.1088/1758-5090/ad30c5⟩

Article dans une revue hal-04749333v1
Deposit thumbnail

Investigation of the motif activity of transcription regulators in pancreatic β-like cell subpopulations differentiated from human induced pluripotent stem cells

Eric Leclerc , Mikhail Pachkov , Lisa Morisseau , Fumiya Tokito , Cecile Legallais et al.

Molecular Omics, 2024, ⟨10.1039/D4MO00082J⟩

Article dans une revue hal-04787625v1
Deposit thumbnail

Transcriptomic profiling analysis of the effect of palmitic acid on 3D spheroids of β-like cells derived from induced pluripotent stem cells

Lisa Morisseau , Fumiya Tokito , Mathilde Lucas , Stéphane Poulain , Soo Hyeon Kim et al.

Gene, 2024, 917, pp.148441. ⟨10.1016/j.gene.2024.148441⟩

Article dans une revue hal-04608624v1
Deposit thumbnail

Generation of β-like cell subtypes from differentiated human induced pluripotent stem cells in 3D spheroids

Lisa Morisseau , Fumiya Tokito , Stéphane Poulain , Valérie Plaisance , Valerie Pawlowski et al.

Molecular Omics, 2023, 19 (10), pp.810-822. ⟨10.1039/D3MO00050H⟩

Article dans une revue hal-04209565v1
Deposit thumbnail

Transcriptomic and proteomic studies suggest the establishment of advanced zonation‐like profiles in human‐induced pluripotent stem cell‐derived liver sinusoidal endothelial cells and carboxypeptidase M‐positive liver progenitor cells cocultured in a fluidic microenvironment

Mathieu Danoy , Stéphane Poulain , Rachid Jellali , Benedikt Scheidecker , Yannick Tauran et al.

Hepatology Research, 2023, 53 (7), pp.661-674. ⟨10.1111/hepr.13893⟩

Article dans une revue hal-04749331v1
Deposit thumbnail

Liver organ-on-chip models for toxicity studies and risk assessment

Taha Messelmani , Lisa Morisseau , Yasuyuki Sakai , Cécile Legallais , Anne Le Goff et al.

Lab on a Chip, 2022, 22 (13), pp.2423-2450. ⟨10.1039/d2lc00307d⟩

Article dans une revue hal-03861401v1

A novel agonist for the HGF receptor MET promotes differentiation of human pluripotent stem cells into hepatocyte-like cells

Yannick Tauran , Lereau-Bernier Myriam , Segard Bertrand David , Danoy Mathieu , Kimura Keiichi et al.

Development, growth & differentiation., 2022, 64 (9), pp.527-536

Article dans une revue hal-04817909v1
Deposit thumbnail

Analysis of the transcriptome and metabolome of pancreatic spheroids derived from human induced pluripotent stem cells and matured in an organ-on-a-chip

Amal Essaouiba , Rachid Jellali , Stéphane Poulain , Fumiya Tokito , Françoise Gilard et al.

Molecular Omics, 2022, 18 (8), pp.791-804. ⟨10.1039/d2mo00132b⟩

Article dans une revue hal-03861419v1

A novel agonist for the HGF receptor MET promotes differentiation of human pluripotent stem cells into hepatocyte‐like cells

Yannick Tauran , Myriam Lereau-Bernier , Bertrand David Segard , Mathieu Danoy , Keiichi Kimura et al.

Development, Growth and Differentiation, 2022, 64 (9), pp.527-536. ⟨10.1111/dgd.12818⟩

Article dans une revue hal-04279694v1

Investigation of the hepatic development in the coculture of hiPSCs-derived LSECs and HLCs in a fluidic microenvironment

Mathieu Danoy , Yannick Tauran , Stephane Poulain , Rachid Jellali , Johanna Bruce et al.

APL Bioengineering, 2021, 5 (2), ⟨10.1063/5.0041227⟩

Article dans une revue hal-03286327v1
Deposit thumbnail

Multi‐omics analysis of hiPSCs‐derived HLCs matured on‐chip revealed patterns typical of liver regeneration

Mathieu Danoy , Yannick Tauran , Stéphane Poulain , Rachid Jellali , Johanna Bruce et al.

Biotechnology and Bioengineering, In press, ⟨10.1002/bit.27667⟩

Article dans une revue hal-03288795v1
Deposit thumbnail

Analysis of the behavior of 2D monolayers and 3D spheroid human pancreatic beta cells derived from induced pluripotent stem cells in a microfluidic environment

Amal Essaouiba , Rachid Jellali , Marie Shinohara , Benedikt Scheidecker , Cécile Legallais et al.

Journal of Biotechnology, 2021, 330, pp.45-56. ⟨10.1016/j.jbiotec.2021.02.009⟩

Article dans une revue hal-03285819v1
Deposit thumbnail

Characterization of the proteome and metabolome of human liver sinusoidal endothelial-like cells derived from induced pluripotent stem cells

Mathieu Danoy , Rachid Jellali , Yannick Tauran , Johanna Bruce , Marjorie Leduc et al.

Differentiation, 2021, 120, pp.1-26. ⟨10.1016/j.diff.2021.06.001⟩

Article dans une revue hal-03288696v1
Deposit thumbnail

Metabolomic profiling during the differentiation of human induced pluripotent stem cells into hepatocyte-like cells

Rachid Jellali , Myriam Lereau Bernier , Yannick Tauran , Françoise Gilard , Mathieu Danoy et al.

Differentiation, 2020, 112, pp.17-26. ⟨10.1016/j.diff.2019.10.006⟩

Article dans une revue hal-02453731v1
Deposit thumbnail

Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies

Amal Essaouiba , Teru Okitsu , R. Kinoshita , Rachid Jellali , Yasuyuki Sakai et al.

Biochemical Engineering Journal, 2020, 164, pp.107783. ⟨10.1016/j.bej.2020.107783⟩

Article dans une revue hal-03095499v1
Deposit thumbnail

Integration of metabolomic and transcriptomic profiling to compare two protocols of differentiation of human induced pluripotent stem cells into hepatocytes

Rachid Jellali , Stéphane Poulain , Myriam Lereau Bernier , Françoise Gilard , Yannick Y. Tauran et al.

Process Biochemistry, 2019, 88, pp.139-147. ⟨10.1016/j.procbio.2019.09.034⟩

Article dans une revue hal-02357452v1

Optimized protocol for the hepatic differentiation of induced pluripotent stem cells in a fluidic microenvironment

Mathieu Danoy , Myriam Lereau Bernier , Keiichi Kimura , Stéphane Poulain , Sachi Kato et al.

Biotechnology and Bioengineering, 2019, 116 (7), pp.1762-1776. ⟨10.1002/bit.26970⟩

Article dans une revue hal-02357453v1

Profiling of derived-hepatocyte progenitors from induced pluripotent stem cells using nanoCAGE promoter analysis

Myriam Lereau Bernier , Stéphane Poulain , Yannick Y. Tauran , Mathieu Danoy , Marie Shinohara et al.

Biochemical Engineering Journal, 2019, 142, pp.7-17. ⟨10.1016/j.bej.2018.11.001⟩

Article dans une revue istex hal-02357456v1
Deposit thumbnail

Analysis of the transcription factors and their regulatory roles during a step-by-step differentiation of induced pluripotent stem cells into hepatocyte-like cells

Yannick Y. Tauran , Stéphane Poulain , Myriam Lereau-Bernier , Mathieu Danoy , Marie Shinohara et al.

Molecular Omics, 2019, ⟨10.1039/C9MO00122K⟩

Article dans une revue hal-02357458v1

Simplest Chemosensor Array for Phosphorylated Saccharides

Yui Sasaki , Eric Leclerc , Vahid Hamedpour , Riku Kubota , Shin-Ya Takizawa et al.

Analytical Chemistry, 2019, ⟨10.1021/acs.analchem.9b03578⟩

Article dans une revue hal-02369560v1

Investigation of the hepatic respiration and liver zonation on rat hepatocytes using an integrated oxygen biosensor in a microscale device

Satomi Matsumoto , Astia Safitri , Mathieu Danoy , Toshiro Maekawa , Haruyuki Kinoshita et al.

Biotechnology Progress, 2019, 35 (5), ⟨10.1002/btpr.2854⟩

Article dans une revue hal-02357455v1

Integration of an oxygen sensor into a polydymethylsiloxane hepatic culture device for two-dimensional gradient characterization

Satomi Matsumoto , Eric Leclerc , Toshiro Maekawa , Haruyuki Kinoshita , Marie Shinohara et al.

Sensors and Actuators B: Chemical, 2018, 273, pp.1062-1069. ⟨10.1016/j.snb.2018.05.053⟩

Article dans une revue hal-02357459v1

Metabolomics-on-a-chip approach to study hepatotoxicity of DDT, permethrin and their mixtures

Rachid Jellali , Françoise Gilard , Vittoria Pandolfi , Audrey Legendre , Marie-José Fleury et al.

Journal of Applied Toxicology, 2018, 38 (8), pp.1121-1134. ⟨10.1002/jat.3624⟩

Article dans une revue hal-02357461v1
Deposit thumbnail

Effects of DDT and permethrin on rat hepatocytes cultivated in microfluidic biochips: Metabolomics and gene expression study

Rachid Jellali , Perrine Zeller , Françoise Gilard , Audrey Legendre , Marie José Fleury et al.

Environmental Toxicology and Pharmacology, 2018, 59, pp.1-12. ⟨10.1016/j.etap.2018.02.004⟩

Article dans une revue hal-02357463v1

Water-in-oil droplet formation in a flow-focusing microsystem using pressure- and flow rate-driven pumps

Sarah Lignel , Anne-Virginie Salsac , Audrey Drelich , Eric Leclerc , Isabelle Pezron

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2017, 531, pp.164-172. ⟨10.1016/j.colsurfa.2017.07.065⟩

Article dans une revue hal-02357482v1

In vitro cyto-biocompatibility study of thin-film transistors substrates using an organotypic culture method

Eric Leclerc , Jean-Luc Duval , Christophe Egles , Satoshi Ihida , Hiroshi Toshiyoshi et al.

Journal of Materials Science: Materials in Medicine, 2017, 28 (1), pp.4. ⟨10.1007/s10856-016-5815-1⟩

Article dans une revue hal-01955190v1

Online monitoring of hepatic rat metabolism by coupling a liver biochip and a mass spectrometer

Franck Merlier , Rachid Jellali , Eric Leclerc

Analyst, 2017, 142 (19), pp.3747-3757. ⟨10.1039/C7AN00973A⟩

Article dans une revue hal-01988812v1

Thin-film-transistor array: an exploratory attempt for high throughput cell manipulation using electrowetting principle

F Azam Shaik , G Cathcart , S Ihida , M Lereau-Bernier , Eric Leclerc et al.

Journal of Micromechanics and Microengineering, 2017, 27 (5), pp.054001. ⟨10.1088/1361-6439/aa66e8⟩

Article dans une revue hal-02357490v1

Transient behavior and relaxation of microcapsules with a cross-linked human serum albumin membrane

Pierre-Yves Gires , Dominique Barthès-Biesel , Eric Leclerc , Anne-Virginie Salsac

Journal of the mechanical behavior of biomedical materials, 2016, 58, pp.2-10. ⟨10.1016/j.jmbbm.2015.09.008⟩

Article dans une revue hal-02019566v1

Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips

Régis Baudoin , Jean-Matthieu Prot , Grégory Nicolas , Jessy Brocheton , Céline Brochot et al.

Xenobiotica, 2013, 43 (2), pp.140-152. ⟨10.3109/00498254.2012.706725⟩

Article dans une revue ineris-00963431v1

Microfluidic technique for measuring microcapsules.

Anne-Virginie Salsac , Eric Leclerc , Dominique Barthès-Biesel

Bioencapsulation Innovations, 2013

Article dans une revue hal-02019778v1

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.

Leila Choucha-Snouber , Caroline Aninat , Laurent Grsicom , Geoffrey Madalinski , Céline Brochot et al.

Biotechnology and Bioengineering, 2013, 110 (2), pp.597-608. ⟨10.1002/bit.24707⟩

Article dans une revue istex inserm-00864839v1
Deposit thumbnail

Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: Application to acetaminophen injury

Jean-Matthieu Prot , Andrei Bunescu , Bénédicte Elena-Herrmann , Caroline Aninat , Leila Choucha Snouber et al.

Toxicology and Applied Pharmacology, 2012, 259 (3), pp.270-280. ⟨10.1016/j.taap.2011.12.017⟩

Article dans une revue hal-00699551v1

Investigation of Oleic Acid, Palmitic Acid and their mixture on the development of hepatic steatosis using liver-on-chip technology

Lisa Morisseau , C. Legallais , Amar Abderrahmani , Yasuyoshi Sakai , Eric Leclerc et al.

49th ESAO Congress, Aug 2023, Bergamo, Italy

Communication dans un congrès hal-04476949v1
Deposit thumbnail

Contrôle découlement et suivi de prolifération dans des biopuces hépatiques

Taha Messelmani , Adam Meziane , William César , Marine Verhulsel , Zied Souguir et al.

25`eme Congrès Français de Mécanique, Aug 2022, Nantes, France

Communication dans un congrès hal-04497647v1

Development of liver-on-chip model integrating LSEC barrier and hepatocytes organoids for toxicity application

Taha Messelmani , Anne Le Goff , Fabrice Soncin , Zied Souguir , Elodie Vandenhaute et al.

The 1st edition of the MicroPhysio conference on "Micro-physiological models: From organoids to organs-on-chip", Apr 2022, Cargese (Corse), France

Communication dans un congrès hal-04497703v1

Development of an advanced liver organ-on-chip integrating hydroscaffold mimicking cell matrix

Taha Messelmani , Zied Souguir , Victoria Maes , Anne Le Goff , Elodie Vandenhaute et al.

47th ESAO Congress, Sep 2021, London (U.K.), United Kingdom

Communication dans un congrès hal-04497725v1

3D liver-on-chip model integrating hydrogel mimicking cell matrix

Taha Messelmani , Zied Souguir , Victoria Maes , Anne Le Goff , Eric Leclerc et al.

TERMIS 6th World Congress, Nov 2021, Maastricht (Netherland), Netherlands

Communication dans un congrès hal-04500618v1

Cryogel integrated microchip : towards a human 3D model of liver cancer

Lilandra Boulais , Rachid Jellali , Ulysse Pereira , Patrick Paullier , Eric Leclerc et al.

Cancer Cells-on-Chip 2, Mar 2019, Lyon, France

Communication dans un congrès hal-04475771v1

Investigation of the Behavior of Rat Pancreatic Islets in an Organ-On-Chip Model

Amal Essaouiba , Teru Okitsu , Rachid Jellali , Marie Shinohara , Mathieu Danoy et al.

IFAO-JSAO Congress, Nov 2019, Osaka (JP), Japan

Communication dans un congrès hal-04475774v1

Liver on chip platform: key questions following 15 years of development

C. Legallais , Rachid Jellali , Eric Leclerc

International MicroNanoconference, Dec 2018, Amsterdam, Netherlands

Communication dans un congrès hal-04475722v1

Relation entre stabilité des émulsions eau-dans-huile et cristallisation de gouttes d’eau générées par microfluidique.

Audrey Drelich , Sarah Lignel , Danièle Clausse , Anne-Virginie Salsac , Eric Leclerc et al.

Journées de Calorimétrie et d’Analyse Thermique JAT 2017, May 2017, Rueil-Malmaison, France

Communication dans un congrès hal-02491826v1

Pharmaco-metabonomic investigation of acetaminophen toxicity on rat primary hepatocytes in microfluidic biochips

Claire Lopez , Mathilde Bayet-Robert , Marc-Emmanuel Dumas , Jean-Matthieu Prot , Alexandre R.R. Pery et al.

7e Journées scientifiques du Réseau Français de Métabolomique et Fluxomique (RFMF), Jun 2013, Amiens, France

Communication dans un congrès hal-00980023v1

Automatic evaluation of the elastic modulus of a capsule membrane

T.X. Chu , Anne-Virginie Salsac , Eric Leclerc , Dominique Barthès-Biesel

Knowledge and Systems Engineering. Advances in Intelligent Systems and Computing, 245, 2013, 978-3-319-02820-0. ⟨10.1007/978-3-319-02821-7_34⟩

Chapitre d'ouvrage hal-02019807v1