Eric Leclerc

Publications

Article dans une revue (36)

Identification of the differential and synergic lipotoxic patterns of oleic acid, palmitic acid, and their mixture in 3D HepG2/C3A tissue using liver‐on‐chip technology Lisa Morisseau,Valérie Pawlowski,Valérie Plaisance,Mathilde Lucas,Cécile Legallaiset al. Biotechnology Progress, 2025, 42 (1), pp.e70075. ⟨10.1002/btpr.70075⟩ Article dans une revue hal-05318221v1
3D hepatic spheroids and liver‐organ on chip models displayed maintenance of hepatic functions and maturation profile in a long‐term culture of the humanized HepaSH cells, a human cell population harvested from chimeric mice Hanyuan Wang,Carla Meschini,Stéphane Poulain,Soo Hyeon Kim,Hiroshi Arakawaet al. Biotechnology Progress, 2025, ⟨10.1002/btpr.70043⟩ Article dans une revue (article de synthèse) hal-05109229v1
Computational modeling of the hepatocytes reveals new insights into alterations in drug metabolism, oxidative stress response, and glutathione detoxification in acetaminophen-induced hepatotoxicity associated with MASLD Yuki Miura,Yasuyuki Sakai,Masaki Nishikawa,Eric Leclerc Computational Toxicology, 2025, 36, pp.100384. ⟨10.1016/j.comtox.2025.100384⟩ Article dans une revue hal-05380695v1
Dynamic, IPSC-derived hepatic tissue tri-culture system for the evaluation of liver physiology in vitro Benedikt Scheidecker,Stéphane Poulain,Masahiro Sugimoto,Taketomo Kido,Takumi Kawanishiet al. Biofabrication, 2024, 16 (2), pp.025037. ⟨10.1088/1758-5090/ad30c5⟩ Article dans une revue hal-04749333v1
Investigation of the motif activity of transcription regulators in pancreatic β-like cell subpopulations differentiated from human induced pluripotent stem cells Eric Leclerc,Mikhail Pachkov,Lisa Morisseau,Fumiya Tokito,Cecile Legallaiset al. Molecular Omics, 2024, ⟨10.1039/D4MO00082J⟩ Article dans une revue hal-04787625v1
Transcriptomic profiling analysis of the effect of palmitic acid on 3D spheroids of β-like cells derived from induced pluripotent stem cells Lisa Morisseau,Fumiya Tokito,Mathilde Lucas,Stéphane Poulain,Soo Hyeon Kimet al. Gene, 2024, 917, pp.148441. ⟨10.1016/j.gene.2024.148441⟩ Article dans une revue hal-04608624v1
Generation of β-like cell subtypes from differentiated human induced pluripotent stem cells in 3D spheroids Lisa Morisseau,Fumiya Tokito,Stéphane Poulain,Valérie Plaisance,Valerie Pawlowskiet al. Molecular Omics, 2023, 19 (10), pp.810-822. ⟨10.1039/D3MO00050H⟩ Article dans une revue hal-04209565v1
Transcriptomic and proteomic studies suggest the establishment of advanced zonation‐like profiles in human‐induced pluripotent stem cell‐derived liver sinusoidal endothelial cells and carboxypeptidase M‐positive liver progenitor cells cocultured in a fluidic microenvironment Mathieu Danoy,Stéphane Poulain,Rachid Jellali,Benedikt Scheidecker,Yannick Tauranet al. Hepatology Research, 2023, 53 (7), pp.661-674. ⟨10.1111/hepr.13893⟩ Article dans une revue hal-04749331v1
Liver organ-on-chip models for toxicity studies and risk assessment Taha Messelmani,Lisa Morisseau,Yasuyuki Sakai,Cécile Legallais,Anne Le Goffet al. Lab on a Chip, 2022, 22 (13), pp.2423-2450. ⟨10.1039/d2lc00307d⟩ Article dans une revue hal-03861401v1
A novel agonist for the HGF receptor MET promotes differentiation of human pluripotent stem cells into hepatocyte-like cells Yannick Tauran,Lereau-Bernier Myriam,Segard Bertrand David,Danoy Mathieu,Kimura Keiichiet al. Development, growth & differentiation., 2022, 64 (9), pp.527-536 Article dans une revue hal-04817909v1
Analysis of the transcriptome and metabolome of pancreatic spheroids derived from human induced pluripotent stem cells and matured in an organ-on-a-chip Amal Essaouiba,Rachid Jellali,Stéphane Poulain,Fumiya Tokito,Françoise Gilardet al. Molecular Omics, 2022, 18 (8), pp.791-804. ⟨10.1039/d2mo00132b⟩ Article dans une revue hal-03861419v1
A novel agonist for the HGF receptor MET promotes differentiation of human pluripotent stem cells into hepatocyte‐like cells Yannick Tauran,Myriam Lereau-Bernier,Bertrand David Segard,Mathieu Danoy,Keiichi Kimuraet al. Development, Growth and Differentiation, 2022, 64 (9), pp.527-536. ⟨10.1111/dgd.12818⟩ Article dans une revue hal-04279694v1
Investigation of the hepatic development in the coculture of hiPSCs-derived LSECs and HLCs in a fluidic microenvironment Mathieu Danoy,Yannick Tauran,Stephane Poulain,Rachid Jellali,Johanna Bruceet al. APL Bioengineering, 2021, 5 (2), ⟨10.1063/5.0041227⟩ Article dans une revue hal-03286327v1
Multi‐omics analysis of hiPSCs‐derived HLCs matured on‐chip revealed patterns typical of liver regeneration Mathieu Danoy,Yannick Tauran,Stéphane Poulain,Rachid Jellali,Johanna Bruceet al. Biotechnology and Bioengineering, 2021, ⟨10.1002/bit.27667⟩ Article dans une revue hal-03288795v1
Analysis of the behavior of 2D monolayers and 3D spheroid human pancreatic beta cells derived from induced pluripotent stem cells in a microfluidic environment Amal Essaouiba,Rachid Jellali,Marie Shinohara,Benedikt Scheidecker,Cécile Legallaiset al. Journal of Biotechnology, 2021, 330, pp.45-56. ⟨10.1016/j.jbiotec.2021.02.009⟩ Article dans une revue hal-03285819v1
Characterization of the proteome and metabolome of human liver sinusoidal endothelial-like cells derived from induced pluripotent stem cells Mathieu Danoy,Rachid Jellali,Yannick Tauran,Johanna Bruce,Marjorie Leducet al. Differentiation, 2021, 120, pp.1-26. ⟨10.1016/j.diff.2021.06.001⟩ Article dans une revue hal-03288696v1
Metabolomic profiling during the differentiation of human induced pluripotent stem cells into hepatocyte-like cells Rachid Jellali,Myriam Lereau Bernier,Yannick Tauran,Françoise Gilard,Mathieu Danoyet al. Differentiation, 2020, 112, pp.17-26. ⟨10.1016/j.diff.2019.10.006⟩ Article dans une revue hal-02453731v1
Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies Amal Essaouiba,Teru Okitsu,R. Kinoshita,Rachid Jellali,Yasuyuki Sakaiet al. Biochemical Engineering Journal, 2020, 164, pp.107783. ⟨10.1016/j.bej.2020.107783⟩ Article dans une revue hal-03095499v1
Integration of metabolomic and transcriptomic profiling to compare two protocols of differentiation of human induced pluripotent stem cells into hepatocytes Rachid Jellali,Stéphane Poulain,Myriam Lereau Bernier,Françoise Gilard,Yannick Y. Tauranet al. Process Biochemistry, 2019, 88, pp.139-147. ⟨10.1016/j.procbio.2019.09.034⟩ Article dans une revue hal-02357452v1
Optimized protocol for the hepatic differentiation of induced pluripotent stem cells in a fluidic microenvironment Mathieu Danoy,Myriam Lereau Bernier,Keiichi Kimura,Stéphane Poulain,Sachi Katoet al. Biotechnology and Bioengineering, 2019, 116 (7), pp.1762-1776. ⟨10.1002/bit.26970⟩ Article dans une revue hal-02357453v1
Profiling of derived-hepatocyte progenitors from induced pluripotent stem cells using nanoCAGE promoter analysis Myriam Lereau Bernier,Stéphane Poulain,Yannick Y. Tauran,Mathieu Danoy,Marie Shinoharaet al. Biochemical Engineering Journal, 2019, 142, pp.7-17. ⟨10.1016/j.bej.2018.11.001⟩ Article dans une revue istex hal-02357456v1
Analysis of the transcription factors and their regulatory roles during a step-by-step differentiation of induced pluripotent stem cells into hepatocyte-like cells Yannick Y. Tauran,Stéphane Poulain,Myriam Lereau-Bernier,Mathieu Danoy,Marie Shinoharaet al. Molecular Omics, 2019, ⟨10.1039/C9MO00122K⟩ Article dans une revue hal-02357458v1
Simplest Chemosensor Array for Phosphorylated Saccharides Yui Sasaki,Eric Leclerc,Vahid Hamedpour,Riku Kubota,Shin-Ya Takizawaet al. Analytical Chemistry, 2019, ⟨10.1021/acs.analchem.9b03578⟩ Article dans une revue hal-02369560v1
Investigation of the hepatic respiration and liver zonation on rat hepatocytes using an integrated oxygen biosensor in a microscale device Satomi Matsumoto,Astia Safitri,Mathieu Danoy,Toshiro Maekawa,Haruyuki Kinoshitaet al. Biotechnology Progress, 2019, 35 (5), ⟨10.1002/btpr.2854⟩ Article dans une revue hal-02357455v1
Integration of an oxygen sensor into a polydymethylsiloxane hepatic culture device for two-dimensional gradient characterization Satomi Matsumoto,Eric Leclerc,Toshiro Maekawa,Haruyuki Kinoshita,Marie Shinoharaet al. Sensors and Actuators B: Chemical, 2018, 273, pp.1062-1069. ⟨10.1016/j.snb.2018.05.053⟩ Article dans une revue hal-02357459v1
Effects of DDT and permethrin on rat hepatocytes cultivated in microfluidic biochips: Metabolomics and gene expression study Rachid Jellali,Perrine Zeller,Françoise Gilard,Audrey Legendre,Marie José Fleuryet al. Environmental Toxicology and Pharmacology, 2018, 59, pp.1-12. ⟨10.1016/j.etap.2018.02.004⟩ Article dans une revue hal-02357463v1
Metabolomics-on-a-chip approach to study hepatotoxicity of DDT, permethrin and their mixtures Rachid Jellali,Françoise Gilard,Vittoria Pandolfi,Audrey Legendre,Marie-José Fleuryet al. Journal of Applied Toxicology, 2018, 38 (8), pp.1121-1134. ⟨10.1002/jat.3624⟩ Article dans une revue hal-02357461v1
Water-in-oil droplet formation in a flow-focusing microsystem using pressure- and flow rate-driven pumps Sarah Lignel,Anne-Virginie Salsac,Audrey Drelich,Eric Leclerc,Isabelle Pezron Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2017, 531, pp.164-172. ⟨10.1016/j.colsurfa.2017.07.065⟩ Article dans une revue hal-02357482v1
In vitro cyto-biocompatibility study of thin-film transistors substrates using an organotypic culture method Eric Leclerc,Jean-Luc Duval,Christophe Egles,Satoshi Ihida,Hiroshi Toshiyoshiet al. Journal of Materials Science: Materials in Medicine, 2017, 28 (1), pp.4. ⟨10.1007/s10856-016-5815-1⟩ Article dans une revue hal-01955190v1
Online monitoring of hepatic rat metabolism by coupling a liver biochip and a mass spectrometer Franck Merlier,Rachid Jellali,Eric Leclerc Analyst, 2017, 142 (19), pp.3747-3757. ⟨10.1039/C7AN00973A⟩ Article dans une revue hal-01988812v1
Thin-film-transistor array: an exploratory attempt for high throughput cell manipulation using electrowetting principle F Azam Shaik,G Cathcart,S Ihida,M Lereau-Bernier,Eric Leclercet al. Journal of Micromechanics and Microengineering, 2017, 27 (5), pp.054001. ⟨10.1088/1361-6439/aa66e8⟩ Article dans une revue hal-02357490v1
Transient behavior and relaxation of microcapsules with a cross-linked human serum albumin membrane Pierre-Yves Gires,Dominique Barthès-Biesel,Eric Leclerc,Anne-Virginie Salsac Journal of the mechanical behavior of biomedical materials, 2016, 58, pp.2-10. ⟨10.1016/j.jmbbm.2015.09.008⟩ Article dans une revue istex hal-02019566v1
Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips Régis Baudoin,Jean-Matthieu Prot,Grégory Nicolas,Jessy Brocheton,Céline Brochotet al. Xenobiotica, 2013, 43 (2), pp.140-152. ⟨10.3109/00498254.2012.706725⟩ Article dans une revue ineris-00963431v1
Microfluidic technique for measuring microcapsules. Anne-Virginie Salsac,Eric Leclerc,Dominique Barthès-Biesel Bioencapsulation Innovations, 2013 Article dans une revue hal-02019778v1
Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip. Leila Choucha-Snouber,Caroline Aninat,Laurent Grsicom,Geoffrey Madalinski,Céline Brochotet al. Biotechnology and Bioengineering, 2013, 110 (2), pp.597-608. ⟨10.1002/bit.24707⟩ Article dans une revue istex inserm-00864839v1
Predictive toxicology using systemic biology and liver microfluidic &quot;on chip&quot; approaches: Application to acetaminophen injury Jean-Matthieu Prot,Andrei Bunescu,Bénédicte Elena-Herrmann,Caroline Aninat,Leila Choucha Snouberet al. Toxicology and Applied Pharmacology, 2012, 259 (3), pp.270-280. ⟨10.1016/j.taap.2011.12.017⟩ Article dans une revue hal-00699551v1

Communication dans un congrès (10)

Investigation of Oleic Acid, Palmitic Acid and their mixture on the development of hepatic steatosis using liver-on-chip technology Lisa Morisseau,C. Legallais,Amar Abderrahmani,Yasuyoshi Sakai,Eric Leclercet al. 49th ESAO Congress, Aug 2023, Bergamo, Italy Communication dans un congrès hal-04476949v1
Contrôle découlement et suivi de prolifération dans des biopuces hépatiques Taha Messelmani,Adam Meziane,William César,Marine Verhulsel,Zied Souguiret al. 25`eme Congrès Français de Mécanique, Aug 2022, Nantes, France Communication dans un congrès hal-04497647v1
Development of liver-on-chip model integrating LSEC barrier and hepatocytes organoids for toxicity application Taha Messelmani,Anne Le Goff,Fabrice Soncin,Zied Souguir,Elodie Vandenhauteet al. The 1st edition of the MicroPhysio conference on "Micro-physiological models: From organoids to organs-on-chip", Apr 2022, Cargese (Corse), France Communication dans un congrès hal-04497703v1
Development of an advanced liver organ-on-chip integrating hydroscaffold mimicking cell matrix Taha Messelmani,Zied Souguir,Victoria Maes,Anne Le Goff,Elodie Vandenhauteet al. 47th ESAO Congress, Sep 2021, London (U.K.), United Kingdom Communication dans un congrès hal-04497725v1
3D liver-on-chip model integrating hydrogel mimicking cell matrix Taha Messelmani,Zied Souguir,Victoria Maes,Anne Le Goff,Eric Leclercet al. TERMIS 6th World Congress, Nov 2021, Maastricht (Netherland), Netherlands Communication dans un congrès hal-04500618v1
Cryogel integrated microchip : towards a human 3D model of liver cancer Lilandra Boulais,Rachid Jellali,Ulysse Pereira,Patrick Paullier,Eric Leclercet al. Cancer Cells-on-Chip 2, Mar 2019, Lyon, France Communication dans un congrès hal-04475771v1
Investigation of the Behavior of Rat Pancreatic Islets in an Organ-On-Chip Model Amal Essaouiba,Teru Okitsu,Rachid Jellali,Marie Shinohara,Mathieu Danoyet al. IFAO-JSAO Congress, Nov 2019, Osaka (JP), Japan Communication dans un congrès hal-04475774v1
Liver on chip platform: key questions following 15 years of development C. Legallais,Rachid Jellali,Eric Leclerc International MicroNanoconference, Dec 2018, Amsterdam, Netherlands Communication dans un congrès hal-04475722v1
Relation entre stabilité des émulsions eau-dans-huile et cristallisation de gouttes d’eau générées par microfluidique. Audrey Drelich,Sarah Lignel,Danièle Clausse,Anne-Virginie Salsac,Eric Leclercet al. Journées de Calorimétrie et d’Analyse Thermique JAT 2017, May 2017, Rueil-Malmaison, France Communication dans un congrès hal-02491826v1
Pharmaco-metabonomic investigation of acetaminophen toxicity on rat primary hepatocytes in microfluidic biochips Claire Lopez,Mathilde Bayet-Robert,Marc-Emmanuel Dumas,Jean-Matthieu Prot,Alexandre R.R. Peryet al. 7e Journées scientifiques du Réseau Français de Métabolomique et Fluxomique (RFMF), Jun 2013, Amiens, France Communication dans un congrès hal-00980023v1

Chapitre d'ouvrage (1)

Automatic evaluation of the elastic modulus of a capsule membrane T.X. Chu,Anne-Virginie Salsac,Eric Leclerc,Dominique Barthès-Biesel Knowledge and Systems Engineering. Advances in Intelligent Systems and Computing, 245, 2013, 978-3-319-02820-0. ⟨10.1007/978-3-319-02821-7_34⟩ Chapitre d'ouvrage hal-02019807v1

Pré-publication, Document de travail (3)

A computational model of the crosstalk between hepatocyte fatty acid metabolism and oxidative stress highlights the key enzymes, metabolites, and detoxification pathways in the context of MASLD Yuki Miura,Cosmin Voican,Yasuyuki Sakai,Masaki Nishikawa,Eric Leclerc 2024 Pré-publication, Document de travail hal-04839420v1
Transcriptomic characterization of the synergy between human induced pluripotent stem cells-derived liver-and pancreas-on-chip coculture Amal Essaouiba,Rachid Jellali,Stéphane Poulain,Soo Hyeon Kim,Mathieu Danoyet al. 2025 Pré-publication, Document de travail hal-05382565v1
Palmitic Acid Induced a Dedifferentiation Profile at the Transcriptome Level: A Collagen Synthesis but no Triglyceride Accumulation in Hepatocyte‐Like Cells Derived From Human‐Induced Pluripotent Stem Cells Cultivated Inside Organ on a Chip Hanyuan Wang,Mathieu Danoy,Ya Gong,Tia Utami,Hiroshi Arakawaet al. 2024 Pré-publication, Document de travail hal-04839414v1