Cosette GRANDVALET Cosette GrandvaletMaître de Conférences (HDR) en MicrobiologieInstitut Agro Dijon

Présentation

My research activity focuses on how microorganisms adapt to their environment. With a background in biochemistry and microbiology, I am particularly interested in the molecular mechanisms involved in the microbial response and adaptation to environmental stress. My work is mainly dedicated to the lactic acid bacterium* Oenococcus oeni*, which plays a key role in the malolactic fermentation of wine. Through an adaptative experimental evolution approach, I try to understand the molecular mechanisms that allow this bacterium to maintain its functionality under the challenging conditions of the winemaking environment.

Publications

Article dans une revue (43)

Impact of N-terminal domain on the sHSP Lo18 function Tiffany Bellanger,Camille Eicher,Fabien Garces,Amélie Cresson,Cosette Grandvaletet al. Scientific Reports, 2025, 16 (3085), pp.1-21. ⟨10.1038/s41598-025-33004-8⟩ Article dans une revue hal-05471043v1
Field Investigation of Flavored Kombucha’s Shelf Life Unveils High Sensitivity of Microbial Dynamics Towards Assimilable Nitrogen Thierry Tran,Damien Steyer,Francois Verdier,Antoine Martin,Hervé Alexandreet al. Food and Bioprocess Technology, 2025, 18 (1), pp.370-391. ⟨10.1007/s11947-024-03470-5⟩ Article dans une revue hal-04616122v1
Investigating Oenococcus oeni citrate locus expression: Role of citR and impact on acid tolerance Camille Eicher,Amaury Aumeunier,Oriane Theveny,Frédérique Julliat,Tiffany Bellangeret al. International Journal of Food Microbiology, 2025, 444, pp.111437. ⟨10.1016/j.ijfoodmicro.2025.111437⟩ Article dans une revue hal-05275716v1
Influence of pH on Oenococcus oeni metabolism: Can the slowdown of citrate consumption improve its acid tolerance? Camille Eicher,Thierry Tran,Edouard Munier,Joana Coulon,Marion Favieret al. Food Research International, 2024, 179, pp.114027. ⟨10.1016/j.foodres.2024.114027⟩ Article dans une revue hal-04434926v1
Citrate metabolism in lactic acid bacteria : is there a beneficial effect for Oenococcus oeni in wine? Camille Eicher,Joana Coulon,Marion Favier,Hervé Alexandre,Cristina Reguantet al. Frontiers in Microbiology, 2024, 14, pp.1-13. ⟨10.3389/fmicb.2023.1283220⟩ Article dans une revue hal-04434889v1
Exploring the role of production and release of proteins for microbial interactions in kombucha Jacqueline Rodriguez Rey,Thierry Tran,Amaury Aumeunier,Aurélie Rieu,François Verdieret al. LWT - Food Science and Technology, 2024, 198, pp.116016. ⟨10.1016/j.lwt.2024.116016⟩ Article dans une revue hal-04594587v1
Identification of Key Parameters Inducing Microbial Modulation during Backslopped Kombucha Fermentation Claire Daval,Thierry Tran,François Verdier,Antoine Martin,Hervé Alexandreet al. Foods, 2024, 13 (8), pp.1181. ⟨10.3390/foods13081181⟩ Article dans une revue hal-04594546v1
Experimental evolution forcing Oenococcus oeni acid tolerance highlights critical role of the citrate locus Frédérique Julliat,Camille Eicher,Nezha Tourti,Philippe Glaser,Nicolas Cabanelet al. Research in Microbiology, 2023, 174 (5), pp.104048. ⟨10.1016/j.resmic.2023.104048⟩ Article dans une revue hal-04034609v1
Microbial Interactions in Kombucha through the Lens of Metabolomics Thierry Tran,Chloé Roullier-Gall,François Verdier,Antoine Martin,Philippe Schmitt-Kopplinet al. Metabolites, 2022, 12 (3), pp.235. ⟨10.3390/metabo12030235⟩ Article dans une revue hal-03641242v1
Use of a Minimal Microbial Consortium to Determine the Origin of Kombucha Flavor Thierry Tran,Kevin Billet,Berta Torres-Cobos,Stefania Vichi,François Verdieret al. Frontiers in Microbiology, 2022, 13, pp.836617. ⟨10.3389/fmicb.2022.836617⟩ Article dans une revue hal-03648444v1
Non-Targeted Metabolomic Analysis of the Kombucha Production Process Thierry Tran,Rémy Romanet,Chloé Roullier-Gall,François Verdier,Antoine Martinet al. Metabolites, 2022, 12 (2), pp.160. ⟨10.3390/metabo12020160⟩ Article dans une revue hal-03578647v1
eGFP Gene Integration in HO: A Metabolomic Impact ? Fanny Bordet,Rémy Romanet,Camille Eicher,Cosette Grandvalet,Géraldine Kleinet al. Microorganisms, 2022, 10 (4), pp.781. ⟨10.3390/microorganisms10040781⟩ Article dans une revue hal-03648411v1
Evolution in Composition of Kombucha Consortia over Three Consecutive Years in Production Context Perrine Mas,Thierry Tran,François Verdier,Antoine Martin,Hervé Alexandreet al. Foods, 2022, 11 (4), pp.614. ⟨10.3390/foods11040614⟩ Article dans une revue hal-03648462v1
Oxygen management during kombucha production: Roles of the matrix, microbial activity, and process parameters Thierry Tran,François Verdier,Antoine Martin,Hervé Alexandre,Cosette Grandvaletet al. Food Microbiology, 2022, 105, pp.104024. ⟨10.1016/j.fm.2022.104024⟩ Article dans une revue hal-03648386v1
Shedding Light on the Formation and Structure of Kombucha Biofilm Using Two-Photon Fluorescence Microscopy Thierry Tran,Cosette Grandvalet,Pascale Winckler,François Verdier,Antoine Martinet al. Frontiers in Microbiology, 2021, 12, pp.725379. ⟨10.3389/fmicb.2021.725379⟩ Article dans une revue hal-03338898v1
Management of Listeria monocytogenes on Surfaces via Relative Air Humidity: Key Role of Cell Envelope Fiona Zoz,Stéphane Guyot,Cosette Grandvalet,Mélanie Ragon,Eric Lesniewskaet al. Foods, 2021, 10 (9), pp.1-15. ⟨10.3390/foods10092002⟩ Article dans une revue hal-03327279v1
Microbiological and technological parameters impacting the chemical composition and sensory quality of kombucha Thierry Tran,Cosette Grandvalet,François Verdier,Antoine Martin,Herve Alexandreet al. Comprehensive Reviews in Food Science and Food Safety, 2020, 19 (4), pp.2050-2070. ⟨10.1111/1541-4337.12574⟩ Article dans une revue hal-02874689v1
Microbial Dynamics between Yeasts and Acetic Acid Bacteria in Kombucha: Impacts on the Chemical Composition of the Beverage Thierry Tran,Cosette Grandvalet,François Verdier,Antoine Martin,Hervé Alexandreet al. Foods, 2020, 9 (7), pp.963. ⟨10.3390/foods9070963⟩ Article dans une revue hal-02921242v1
CtsR, the Master Regulator of Stress-Response in Oenococcus oeni, Is a Heat Sensor Interacting With ClpL1 Maud Darsonval,Frédérique Julliat,Tarek Msadek,Hervé Alexandre,Cosette Grandvalet Frontiers in Microbiology, 2018, 9, pp.1-14. ⟨10.3389/fmicb.2018.03135⟩ Article dans une revue hal-01986589v1
Oenococcus oeni: Queen of the cellar, nightmare of geneticists Cosette Grandvalet Microbiology, 2017, 163 (3), pp.297 - 299. ⟨10.1099/mic.0.000456⟩ Article dans une revue hal-01533323v1
Listeria monocytogenes ability to survive desiccation: Influence of serotype, origin, virulence, and genotype Fiona Zoz,Cosette Grandvalet,Emilie Lang,Cyril Laconelli,Patrick Gervaiset al. International Journal of Food Microbiology, 2017, 248, pp.82 - 89. ⟨10.1016/j.ijfoodmicro.2017.02.010⟩ Article dans une revue hal-01509875v1
Genetically engineered Oenococcus oeni strains to highlight the impact of estA2 and estA7 esterase genes on wine ester profile Maud Darsonval,Hervé Alexandre,Cosette Grandvalet Food Microbiology, 2016, 60, pp.21 - 28. ⟨10.1016/j.fm.2016.06.012⟩ Article dans une revue hal-01446229v1
The antisense RNA approach: a new application for in vivo investigation of the stress response of Oenococcus oeni, a wine-associated lactic acid bacterium Maud Darsonval,Tarek Msadek,Hervé Alexandre,Cosette Grandvalet Applied and Environmental Microbiology, 2016, 82 (1), pp.18-26. ⟨10.1128/AEM.02495-15⟩ Article dans une revue hal-01446281v1
Control of Relative Air Humidity as a Potential Means to Improve Hygiene on Surfaces: A Preliminary Approach with Listeria monocytogenes Fiona Zoz,Cyril Laconelli,Émilie Lang,Stéphane Guyot,Cosette Grandvaletet al. PLoS ONE, 2016, 11 (2), ⟨10.1371/journal.pone.0148418⟩ Article dans une revue hal-01466198v1
Cyclopropane Fatty Acid Synthase from Oenococcus oeni: Expression in Lactococcus lactis subsp. Cremoris and Biochemical Characterization Thi Mai Huong To,Cosette Grandvalet,Hervé Alexandre,Raphaëlle Tourdot-Maréchal Archives of Microbiology, 2015, 197 (9), pp.1063-1074. ⟨10.1007/s00203-015-1143-y⟩ Article dans une revue hal-01326090v1
Tyrosine-containing peptides are precursors of tyramine produced by Lactobacillus plantarum strain IR BL0076 isolated from wine Maryse Bonnin-Jusserand,Cosette Grandvalet,Aurélie Rieu,Stéphanie Weidmann,Hervé Alexandre BMC Microbiology, 2012, 12 (1), pp.199. ⟨10.1186/1471-2180-12-199⟩ Article dans une revue hal-03140066v1
Cyclopropanation of Membrane Unsaturated Fatty Acids Is Not Essential to the Acid Stress Response of Lactococcus lactis subsp. cremoris Thi Mai Huong To,Cosette Grandvalet,Raphaëlle Tourdot-Maréchal Applied and Environmental Microbiology, 2011, 77 (10) Article dans une revue hal-01326108v1
Molecular Cloning, Heterologous Expression, and Characterization of Ornithine Decarboxylase from Oenococcus oeni Maryse Bonnin-Jusserand,Cosette Grandvalet,Vanessa David,Hervé Alexandre Journal of Food Protection, 2011, 74 (8), pp.1309-1314. ⟨10.4315/0362-028X.JFP-10-466⟩ Article dans une revue hal-03140059v1
Biogenic amines in fermented foods G. Spano,P. Russo,Aline Lonvaud-Funel,Patrick Lucas,H. Alexandreet al. European Journal of Clinical Nutrition, 2010, 64, pp.S95-S100. ⟨10.1038/ejcn.2010.218⟩ Article dans une revue hal-02666992v1
Peptidases specific for proline-containing peptides and their unusual peptide-dependent regulation in Oenococcus oeni Jean-Francois Ritt,Fabienne Remize,Cosette Grandvalet,Jean Guzzo,Danièle Atlanet al. Journal of Applied Microbiology, 2009, 106 (3), pp.801--813. ⟨10.1111/j.1365-2672.2008.04032.x⟩ Article dans une revue hal-01201608v1
Changes in membrane lipid composition in ethanol- and acid-adapted Oenococcus oeni cells: characterization of the cfa gene by heterologous complementation Cosette Grandvalet,Juan Simón Assad-García,Son Chu-Ky,Marie Tollot,Jean Guzzoet al. Microbiology, 2008, 154 (9), pp.2611-2619. ⟨10.1099/mic.0.2007/016238-0⟩ Article dans une revue hal-03140144v1
An improved protocol for electroporation of Oenococcus oeni ATCC BAA-1163 using ethanol as immediate membrane fluidizing agent Juan-Simon Assad-Garcia,Maryse Bonnin-Jusserand,Dominique D. Garmyn,Jean Guzzo,Hervé Alexandreet al. Letters in Applied Microbiology, 2008, 47 (4), pp.333 - 338. ⟨10.1111/j.1472-765X.2008.02435.x⟩ Article dans une revue hal-02663266v1
Real-time PCR for characterizing the stress response of Oenococcus oeni in a wine-like medium Charlotte Beltramo,Nicolas Desroche,Raphaëlle Tourdot-Maréchal,Cosette Grandvalet,Jean Guzzo Research in Microbiology, 2006, 157 (3), pp.267-274. ⟨10.1016/j.resmic.2005.07.006⟩ Article dans une revue istex hal-03140049v1
CtsR Is the Master Regulator of Stress Response Gene Expression in Oenococcus oeni Cosette Grandvalet,Françoise Coucheney,Charlotte Beltramo,Jean Guzzo Journal of Bacteriology, 2005, 187 (16), pp.5614-5623. ⟨10.1128/JB.187.16.5614-5623.2005⟩ Article dans une revue hal-03140158v1
Expression différentielle des deux gènes du locus clpP-clpL de Oenococcus oeni Charlotte Beltramo,Cosette Grandvalet,Jean Guzzo Le Lait, 2004, 84 (1-2), pp.87-93. ⟨10.1051/lait:2003035⟩ Article dans une revue hal-00895520v1
Evidence for multiple levels of regulation of Oenococcus oeni clpP-clpL locus expression in response to stress. Charlotte Beltramo,Cosette Grandvalet,Fabrice H.F. Pierre,Jean Guzzo Journal of Bacteriology, 2004, 186 (7), pp.2200-5. ⟨10.1128/JB.186.7.2200–2205.2003⟩ Article dans une revue hal-02670232v1
Identification of genes involved in the activation of the Bacillus thuringiensis inhA metalloprotease gene at the onset of sporulation Cosette Grandvalet,M. Gominet,Didier D. Lereclus Microbiology, 2001, 147 (7), pp.1805-1813 Article dans une revue hal-02679315v1
Regulation of toxin and virulence gene transcription in Bacillus thuringiensis Didier D. Lereclus,Hervé Agaisse,Cosette Grandvalet,S. Salamitou,M. Gominet International Journal of Medical Microbiology, 2000, 290 (4-5), pp.295-299 Article dans une revue hal-02696391v1
The RheA repressor is the thermosensor of the HSP18 heat shock response in Streptomyces albus Pascale Servant,Cosette Grandvalet,Philippe Mazodier Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (7), pp.3538-3543. ⟨10.1073/pnas.97.7.3538⟩ Article dans une revue hal-03140180v1
Alteration of the synthesis of the Clp ATP-dependent protease affects morphological and physiological differentiation in Streptomyces Valerie de Crecy-Lagard,Pascale Servant-Moisson,Julie Viala,Cosette Grandvalet,Philippe Mazodier Molecular Microbiology, 1999, 32 (3), pp.505-517. ⟨10.1046/j.1365-2958.1999.01364.x⟩ Article dans une revue hal-03140074v1
The ClpB ATPase of Streptomyces albus G belongs to the HspR heat shock regulon Cosette Grandvalet,Valerie de Crecy-Lagard,Philippe Mazodier Molecular Microbiology, 1999, 31 (2), pp.521-532. ⟨10.1046/j.1365-2958.1999.01193.x⟩ Article dans une revue hal-03140079v1
hrcA, Encoding the Repressor of the groELGenes in Streptomyces albus G, Is Associated with a SeconddnaJ Gene Cosette Grandvalet,Georges Rapoport,Philippe Mazodier Journal of Bacteriology, 1998, 180 (19), pp.5129-5134. ⟨10.1128/JB.180.19.5129-5134.1998⟩ Article dans une revue hal-03140129v1
Disruption of hspR , the repressor gene of the dnaK operon in Streptomyces albus G Cosette Grandvalet,Pascale Servant,Philippe Mazodier Molecular Microbiology, 1997, 23 (1), pp.77-84. ⟨10.1046/j.1365-2958.1997.1811563.x⟩ Article dans une revue hal-03140133v1

Poster de conférence (20)

Continuing the story of experimental evolution in Oenococcus oeni to improve its acid tolerance: study of the citrate locus expression Camille Eicher,Amaury Aumeunier,Oriane Theveny,Frédérique Julliat,Tiffany Bellangeret al. Colloque Harmi, Sep 2025, Dole, France Poster de conférence hal-05515798v1
Metabolomics to decode microbial interactions in kombucha beverage Thierry Tran,Chloé Roullier-Gall,Francois Verdier,Antoine Martin,Philippe Schmitt-Kopplinet al. 10th FEMS Congress of European Microbiologists, Jul 2023, Hambourg, Germany. , 2023 Poster de conférence hal-04209781v1
Management of Listeria monocytogenes on surfaces by the mean of Relative Air Humidity (RAH) Stéphane Guyot,Fiona Zoz,Cosette Grandvalet,Sébastien Dupont,Mélanie Ragonet al. International Congress on Engineering and Food 14, Jun 2023, Nantes, France Poster de conférence hal-05290010v1
Control of Listeria monocytogenes present on surfaces by managing the Relative Humidity of the air. International Congress on Engineering and Food Stéphane Guyot,Fiona Zoz,Cosette Grandvalet,Sébastien Dupont,Mélanie Ragonet al. International Congress on Engineering and Food (ICEF14), 2023, Nantes, France Poster de conférence hal-05251566v1
Polyphenols in kombucha: impact of infusion time on extraction and investigation of their behavior during &quot;fermentation Thierry Tran,Cosette Grandvalet,François Verdier,Antoine Martin,Herve Alexandreet al. Wine Active Compounds 2022, Jun 2022, Dijon, France. Poster de conférence hal-03773246v1
Maîtrise de Listeria monocytogenes sur des surfaces par le contrôle de l’Humidité Relative de l’Air Stéphane Guyot,Cosette Grandvalet,Sébastien Dupont,Mélanie Ragon,Firmesse, Oet al. XVIIIème congrès de la Société Française de Génie des Procédés, Nov 2022, Toulouse, France Poster de conférence hal-05290290v1
Directed evolution of oenococcus oeni to improve acid-tolerance reveals fixed beneficial mutations in the citrate locus Camille Eicher,Frédérique Julliat,Joana Coulon,Marion Favier,Herve Alexandreet al. 27th International ICFMH Conférence FoodMicro, Jul 2022, Athènes, Greece. Poster de conférence hal-03773876v1
Polyphenols in kombucha: Metabolomic analysis of biotransformations during fermentation Thierry Tran,Rémy Romanet,Chloé Roullier-Gall,François Verdier,Antoine Martinet al. 5th International Conference on Wine Active Compounds (WAC 2022), Jun 2022, Dijon, France. Poster de conférence hal-03773257v1
Directed evolution of Oenococcus oeni to improve acid-tolerance reveals fixed beneficial mutations in the citrate locus. Camille Eicher,Frédérique Julliat,Coulon, J,Favier, M,H. Alexandreet al. Foodmicro 2022 – Next generation challenges in food microbiology., Aug 2022, Athens, Greece Poster de conférence hal-05290019v1
Adaptive evolution to improve acid tolerance in Oenococcus oeni Frédérique Julliat,N. Tourti,Stéphane Guyot,Herve Alexandre,Cosette Grandvalet 11th international synposium of oenology of Bordeaux, Jun 2019, Bordeaux, France Poster de conférence hal-03150729v1
Using CRISPR/Cas platform for Genetic Modification of Commercial Saccharomyces cerevisiae strains C. Eicher,Géraldine L. Klein,Pascale Winckler,Jean-Luc Parrou,Hervé Alexandreet al. OENO-IVAS 2019, Jun 2019, Bordeaux, France Poster de conférence hal-02466806v1
Improving acid tolerance in Oenococcus oeni by Adaptive Evolution Frédérique Julliat,Stéphane Guyot,Herve Alexandre,Cosette Grandvalet 12th International Symposium on Lactic Acid Bacteria (LAB), Aug 2017, Egmond aan Zee, Netherlands Poster de conférence hal-03150712v1
Oenococcus oeni : advances in molecular genetics Cosette Grandvalet,Maud Darsonval,Frédérique Julliat,Herve Alexandre 12th International Symposium on Lactic Acid Bacteria (LAB), Aug 2017, Egmond aan Zee, Netherlands Poster de conférence hal-03150705v1
Improving acid tolerance in Oenococcus oeni by adaptative evolution. Frédérique Julliat,Stéphane Guyot,H. Alexandre,Cosette Grandvalet 12th International Symposium on Lactic Acid Bacteria. Egmond aan Zee,, Aug 2017, Netherlands, Netherlands Poster de conférence hal-05290030v1
Improving acid tolerance in Oenococcus oeni by Adaptive Evolution. Frédérique Julliat,Stéphane Guyot,H. Alexandre,Cosette Grandvalet 23ème Forum des Jeunes Chercheurs, Jun 2017, Dijon, France Poster de conférence hal-05290385v1
Use of relative fluctuations to kill foodborne pathogen Listeria monocytogenes Fiona Zoz,Stéphane Guyot,Cosette Grandvalet,Patrick Gervais,Laurent Beney European Congress of the International Association of Food Protection. Cardiff, Apr 2015, Wales, United Kingdom Poster de conférence hal-05290087v1
Use of antisense RNA to modulate HSP gene expression in oenococcus oeni Maud Darsonval,Tarek Msadek,Herve Alexandre,Cosette Grandvalet FEMS 6th congress of european Microbiologists, Jun 2015, Maastricht, Netherlands Poster de conférence hal-03150745v1
Use of relative humidity fluctuations to kill foodborne pathogen Listeria monocytogenes Fiona Zoz,Stéphane Guyot,Cosette Grandvalet,Patrick Gervais,Laurent Beney 21ème Forum des Jeunes chercheurs, Jun 2015, Dijon, France Poster de conférence hal-05290389v1
Maitrise de l’humidité relative pour contrôler la viabilité de Listeria monocytogenes Fiona Zoz,Stéphane Guyot,Cosette Grandvalet,Patrick Gervais,Laurent Beney 11ème édition du congrès National de la Société Française de Microbiologie, Mar 2015, Paris, France Poster de conférence hal-05290323v1
Use of relative humidity fluctuations to kill foodborne pathogen Listeria monocytogenes Fiona Zoz,Stéphane Guyot,Cosette Grandvalet,Patrick Gervais,Laurent Beney Food Micro, Sep 2014, Nantes, France Poster de conférence hal-05290118v1

Chapitre d'ouvrage (1)

Les bactéries lactiques en oenologie : Connaissances actuelles H. Alexandre,Cosette Grandvalet,Michèle Guilloux-Benatier,Fabienne Remize-Barnavon,Raphaëlle Tourdot-Maréchal Les bactéries lactiques en oenologie : Connaissances actuelles, Lavoisier / Tec & Doc, pp.172, 2008, 978-2-7430-1041-6 Chapitre d'ouvrage hal-05261536v1