Cyril Goudet

Publications

Article dans une revue (57)

Conformational diversity in class C GPCR positive allosteric modulation Giuseppe Cannone,Ludovic Berto,Fanny Malhaire,Gavin Ferguson,Aurelien Fouillenet al. Nature Communications, 2025, 16 (1), pp.619. ⟨10.1038/s41467-024-55439-9⟩ Article dans une revue hal-04889109v1
A photoswitchable positive allosteric modulator to control the activation of the metabotropic glutamate receptor 5 by light Anaëlle Dumazer,Roser Borras-Tuduri,Iona Truong,Xiaojing Cong,Fanny Malhaireet al. Biochemical Pharmacology, 2025, 240, pp.117065. ⟨10.1016/j.bcp.2025.117065⟩ Article dans une revue hal-05140566v1
Bistable and Water‐Operable Hemiindigo Photoswitches Allow Optical Control of Acetylcholinesterase Activity with Visible Light Letícia da Mata Lazinski,Morane Beaumet,Frédérique Loiseau,Cyril Goudet,Martial Boggio‐pasquaet al. ChemistryEurope, 2025, 3 (5), pp.e202500221. ⟨10.1002/ceur.202500221⟩ Article dans une revue hal-05339073v1
Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity Silvia Panarello,Aleix González-Díez,Alice E Berizzi,Fanny Malhaire,Roser Borràs-Tuduríet al. iScience, 2024, 27 (6), pp.110123. ⟨10.1016/j.isci.2024.110123⟩ Article dans une revue hal-04609139v1
Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain Nunzia Cristiano,Alexandre Cabayé,Isabelle Brabet,Ralf Glatthar,Amelie Toraet al. Journal of Medicinal Chemistry, In press, 67 (14), pp.11662-11687. ⟨10.1021/acs.jmedchem.3c01924⟩ Article dans une revue hal-04569147v1
Optical Control of Adenosine A 2A Receptor Using Istradefylline Photosensitivity Anaëlle Dumazer,Xavier Gómez-Santacana,Fanny Malhaire,Chris Jopling,Damien Maurelet al. ACS Chemical Neuroscience, In press, 15 (3), pp.645-655. ⟨10.1021/acschemneuro.3c00721⟩ Article dans une revue hal-04425630v1
A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs Serena Notartomaso,Nico Antenucci,Mariacristina Mazzitelli,Xavier Rovira,Serena Boccellaet al. eLife, 2024, 13, pp.e94931. ⟨10.7554/eLife.94931⟩ Article dans une revue hal-04676043v1
Photopharmacological manipulation of amygdala metabotropic glutamate receptor mGlu4 alleviates neuropathic pain Vanessa Pereira,Juri Aparicio Arias,Amadeu Llebaria,Cyril Goudet Pharmacological Research, 2023, 187, pp.106602. ⟨10.1016/j.phrs.2022.106602⟩ Article dans une revue (data paper) hal-03914258v1
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors Stephen Alexander,Arthur Christopoulos,Anthony Davenport,Eamonn Kelly,Alistair Mathieet al. British Journal of Pharmacology, 2023, 180 (S2), pp.S23-S144. ⟨10.1111/bph.16177⟩ Article dans une revue hal-04858591v1
Editorial: Molecular mechanisms of nociception Cyril Goudet,Fabien Marchand Frontiers in Molecular Neuroscience, 2022, 15, pp.1025230. ⟨10.3389/fnmol.2022.1025230⟩ Article dans une revue hal-03805607v1
Les avancées récentes dans le domaine de la biologie structurale des récepteurs couplés aux protéines G de la classe C : Le récepteur métabotropique du glutamate 5 Ludovic Berto,Anaëlle Dumazer,Fanny Malhaire,Giuseppe Cannone,Vinothkumar Kuttiet al. Biologie Aujourd'hui, 2021, 215 (3-4), pp.85-94. ⟨10.1051/jbio/2021013⟩ Article dans une revue hal-03744975v2
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors Stephen Alexander,Arthur Christopoulos,Anthony Davenport,Eamonn Kelly,Alistair Mathieet al. British Journal of Pharmacology, 2021, 178 (S1), pp.e0243333. ⟨10.1111/bph.15538⟩ Article dans une revue hal-03875300v1
International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors Karen J Gregory,Cyril Goudet Pharmacological Reviews, 2021, 73 (1), pp.521-569. ⟨10.1124/pr.119.019133⟩ Article dans une revue hal-03099669v1
Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations Chady Nasrallah,Giuseppe Cannone,Julie Briot,Karine Rottier,Alice Berizziet al. Cell Reports, 2021, 36 (9), pp.109648. ⟨10.1016/j.celrep.2021.109648⟩ Article dans une revue hal-03340751v1
Development and validation of a mass spectrometry binding assay for mGlu5 receptor Maria Ricart-Ortega,Alice Berizzi,Juanlo Catena,Fanny Malhaire,Lourdes Muñozet al. Analytical and Bioanalytical Chemistry, In press, 412 (22), pp.5525-5535. ⟨10.1007/s00216-020-02772-9⟩ Article dans une revue hal-02884945v1
Mechanistic insights into light-driven allosteric control of GPCR biological activity Maria Ricart-Ortega,Alice Berizzi,Vanessa Pereira,Fanny Malhaire,Juanlo Catenaet al. ACS Pharmacology & Translational Science, 2020, 3 (5), pp.883-895. ⟨10.1021/acsptsci.0c00054⟩ Article dans une revue hal-02924800v1
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors Stephen Alexander,Arthur Christopoulos,Anthony P Davenport,Eamonn Kelly,Alistair Mathieet al. British Journal of Pharmacology, 2019, 176 (S1), pp.S21-S141. ⟨10.1111/bph.14748⟩ Article dans une revue hal-02388696v1
Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors Vanessa Pereira,Cyril Goudet Frontiers in Molecular Neuroscience, 2019, 11, pp.464. ⟨10.3389/fnmol.2018.00464⟩ Article dans une revue hal-02388671v1
Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology Cyril Goudet,Xavier Rovira,Amadeu Llebaria Current Opinion in Pharmacology, 2018, 38, pp.8-15. ⟨10.1016/j.coph.2018.01.007⟩ Article dans une revue hal-02388700v1
Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite® assays Abderazak Belhocine,Pietro Veglianese,Candide Hounsou,Elodie Dupuis,Francine C. Acheret al. Neuropharmacology, 2018, 140, pp.233-245. ⟨10.1016/j.neuropharm.2018.07.032⟩ Article dans une revue istex hal-02388698v1
Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites Chelliah Selvam,Isabelle Lemasson,Isabelle Brabet,Nadia Oueslati,Berin Karamanet al. Journal of Medicinal Chemistry, 2018, 61 (5), pp.1969-1989. ⟨10.1021/acs.jmedchem.7b01438⟩ Article dans une revue hal-02018007v1
Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4 Charleine Zussy,X. Gomez-Santacana,Xavier Rovira,Dimitri de Bundel,S. Ferrazzoet al. Molecular Psychiatry, 2018, 23 (3), pp.509-520. ⟨10.1038/mp.2016.223⟩ Article dans une revue hal-02073218v1
Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3 Amélie S. Tora,Xavier Rovira,Anne-Marinette Cao,Alexandre Cabaye,Linnea Olofssonet al. Neuropharmacology, 2018, 140, pp.275-286. ⟨10.1016/j.neuropharm.2018.08.011⟩ Article dans une revue hal-02346230v1
Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer Junke Liu,Zongyong Zhang,David Moreno-Delgado,James Ar Dalton,Xavier Roviraet al. eLife, 2017, 6, ⟨10.7554/eLife.26985⟩ Article dans une revue hal-02073040v1
Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu 5 negative allosteric modulation Xavier Gómez-Santacana,James Dalton,Xavier Rovira,Jean-Philippe Pin,Cyril Goudetet al. European Journal of Medicinal Chemistry, 2017, 127, pp.567-576. ⟨10.1016/j.ejmech.2017.01.013⟩ Article dans une revue hal-02066019v1
Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals Xavier Gómez-Santacana,Silvia Pittolo,Xavier Rovira,Marc Lopez,Charleine Zussyet al. ACS Central Science, 2017, 3 (1), pp.81-91. ⟨10.1021/acscentsci.6b00353⟩ Article dans une revue hal-02066097v1
Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator Joan Font,Marc López-Cano,Serena Notartomaso,Pamela Scarselli,Paola Di Pietroet al. eLife, 2017, 6, ⟨10.7554/elife.23545.001⟩ Article dans une revue hal-03549950v1
OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity Xavier Rovira,Ana Trapero,Silvia Pittolo,Charleine Zussy,Adèle Faucherreet al. Cell Chemical Biology, 2016, 23 (8), pp.929--34. ⟨10.1016/j.chembiol.2016.06.013⟩ Article dans une revue hal-01941168v1
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III Tri H. V. Huynh,Mette N. Erichsen,Amélie S. Tora,Cyril Goudet,Emmanuelle Sagotet al. Journal of Medicinal Chemistry, 2016, 59, pp.914-924. ⟨10.1021/acs.jmedchem.5b01333⟩ Article dans une revue hal-01288609v1
Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective James Dalton,Isaias Lans,Xavier Rovira,Fanny Malhaire,Xavier Gómez-Santacanaet al. Current Neuropharmacology, 2016, 14 (5), pp.441-454. ⟨10.2174/1570159x13666150407231417⟩ Article dans une revue hal-02448289v1
Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors Xavier Rovira,Fanny Malhaire,Pauline Scholler,Jordi Rodrigo,P. Gonzalez-Bulneset al. FASEB Journal, 2015, 29 (1), pp.116--30. ⟨10.1096/fj.14-257287⟩ Article dans une revue hal-01943324v1
Determination of the absolute configuration of phosphinic analogues of glutamate Bruno Commare,Delphine Rigault,Isabelle Lemasson,Patrick Deschamps,Alain Tomaset al. Organic & Biomolecular Chemistry, 2015, 13 (4), pp.1106-1112. ⟨10.1039/C4OB01960A⟩ Article dans une revue hal-02268872v1
Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers Pavel Ivashkin,Gérald Lemonnier,Amélie S. Tora,Jean-Philippe Pin,Cyril Goudetet al. Bioorganic and Medicinal Chemistry Letters, 2015, 25 (12), pp.2523-2526. ⟨10.1016/j.bmcl.2015.04.043⟩ Article dans une revue hal-01180138v1
Allosteric modulation of metabotropic glutamate receptors by chloride ions Amélie S. Tora,Xavier Rovira,Ibrahima Dione,Hugues-Olivier Bertrand,Isabelle Brabetet al. FASEB Journal, 2015, 29 (10), pp.4174-4188. ⟨10.1096/fj.14-269746⟩ Article dans une revue hal-02065116v1
Therapeutic potential of group III metabotropic glutamate receptor ligands in pain Francine Acher,Cyril Goudet Current Opinion in Pharmacology, 2015, 20, pp.64-72. ⟨10.1016/j.coph.2014.11.007⟩ Article dans une revue hal-01950127v1
Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor Xavier Rovira,Youssef Harrak,Ana Trapero,Patricia Gonzalez-Bulnes,Fanny Malhaireet al. ChemMedChem, 2014, 9 (12), pp.2685--98. ⟨10.1002/cmdc.201402190⟩ Article dans une revue istex hal-01943327v1
An allosteric modulator to control endogenous G protein-coupled receptors with light S. Pittolo,X. Gomez-Santacana,K. Eckelt,Xavier Rovira,J. Daltonet al. Nature Chemical Biology, 2014, 10 (10), pp.813--5. ⟨10.1038/nchembio.1612⟩ Article dans une revue hal-01942934v1
Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor Bruno Vilar,Jérôme Busserolles,Bing Ling,Sophie Laffray,Lauriane Ulmannet al. Journal of Neuroscience, 2013, 33 (48), pp.18951-18965. ⟨10.1523/JNEUROSCI.1221-13.2013⟩ Article dans une revue hal-02448295v1
Α-amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4. Gérald Lemonnier,Cédric Lion,Jean-Charles Quirion,Jean-Philippe Pin,Cyril Goudetet al. Bioorganic and Medicinal Chemistry, 2012, 20 (15), pp.4716-26. ⟨10.1016/j.bmc.2012.06.006⟩ Article dans une revue istex hal-00996602v1
Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors F. Fazio,L. Lionetto,G. Molinaro,H. Bertrand,F. Acheret al. Molecular Pharmacology, 2012, 81 (5), pp.643-656. ⟨10.1124/mol.111.074765⟩ Article dans une revue hal-02448364v1
A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. Cyril Goudet,Bruno Vilar,Tiphanie Courtiol,Thierry Deltheil,Thomas Bessironet al. FASEB Journal, 2012, 26 (4), pp.1682-93. ⟨10.1096/fj.11-195941⟩ Article dans une revue hal-01182946v1
A new Selective Metabotropic Glutamate Receptor type 4 Agonist Reveals New ways to Develop Subtype Selective Orthosteric Ligands with Potential Therapeutic Effects Cyril Goudet,Bruno Vilar,Tiphanie Courtiol,Thierry Deltheil,Thomas Bessironet al. Current Neuropharmacology, 2011, 9 (1), pp.26 Article dans une revue hal-01384798v1
A Virtual Screening Hit Reveals New Possibilities for Developing Group III Metabotropic Glutamate Receptor Agonists Chelliah Selvam,Nadia Oueslati,Isabelle Lemasson,Isabelle Brabet,Delphine Rigaultet al. Journal of Medicinal Chemistry, 2010, 53 (7), pp.2797-2813. ⟨10.1021/jm901523t⟩ Article dans une revue hal-05346713v1
Is metabotropic glutamate receptor mGlu4R a good target to treat Parkinson's disease symptoms? Design and evaluation of potent and selective agonists Isabelle A. Lemasson,Chelliah Selvam,Nadia Oueslati,Isabelle Brabet,Tiphanie Courtiolet al. Abstracts of Papers of the American Chemical Society, 2009, 238 Article dans une revue hal-01384832v1
LSP1-2111, a new orthosteric group III mGlur agonist with preferential activity on mGluR4, modulates the striatopallidal synapse and alleviates parkinsonian symptoms C. Beurrier,D. Revy,S. Lopez,M. Lherondel,Cyril Goudetet al. Neuropharmacology, 2008, 55 (4), pp.587-588. ⟨10.1016/j.neuropharm.2008.06.015⟩ Article dans une revue istex hal-01384860v1
N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. Yelin Chen,Cyril Goudet,Jean-Philippe Pin,P Jeffrey Conn Molecular Pharmacology, 2008, 73 (3), pp.909-18. ⟨10.1124/mol.107.040097⟩ Article dans une revue inserm-00318958v1
Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Yelin Chen,Yi Nong,Cyril Goudet,Kamondanai Hemstapat,Tomas de Pauliset al. Molecular Pharmacology, 2007, 71 (5), pp.1389-98. ⟨10.1124/mol.106.032425⟩ Article dans une revue inserm-00319012v1
Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists. Pauline Sibille,Sébastien Lopez,Isabelle Brabet,Ornella Valenti,Nadia Oueslatiet al. Journal of Medicinal Chemistry, 2007, 50 (15), pp.3585-95. ⟨10.1021/jm070262c⟩ Article dans une revue istex inserm-00318976v1
Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain Cyril Goudet,Eric Chapuy,Abdelkrim Alloui,Francine Acher,Jean-Philippe Pinet al. Pain, 2007, 137 (1), pp.112-124. ⟨10.1016/j.pain.2007.08.020⟩ Article dans une revue inserm-00318859v1
L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency. Chelliah Selvam,Cyril Goudet,Nadia Oueslati,Jean-Philippe Pin,Francine C. Acher Journal of Medicinal Chemistry, 2007, 50 (19), pp.4656-64. ⟨10.1021/jm070400y⟩ Article dans une revue istex inserm-00318965v1
D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation. Eric Trinquet,Michel Fink,Hervé Bazin,Florence Grillet,Fabrice Maurinet al. Analytical Biochemistry, 2006, 358 (1), pp.126-35. ⟨10.1016/j.ab.2006.08.002⟩ Article dans une revue istex inserm-00318996v1
Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR. Veronika Hlavackova,Cyril Goudet,Julie Kniazeff,Alice Zikova,Damien Maurelet al. EMBO Journal, 2005, 24 (3), pp.499-509. ⟨10.1038/sj.emboj.7600557⟩ Article dans une revue inserm-00318934v1
Allosteric functioning of dimeric class C G-protein-coupled receptors. Jean-Philippe Pin,Julie Kniazeff,Jianfeng Liu,Virginie Binet,Cyril Goudetet al. FEBS Journal, 2005, 272, pp.2947-55. ⟨10.1111/j.1742-4658.2005.04728.x⟩ Article dans une revue inserm-00094959v1
Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators. Cyril Goudet,Julie Kniazeff,Veronika Hlavackova,Fanny Malhaire,Damien Maurelet al. Journal of Biological Chemistry, 2005, 280 (26), pp.24380-5. ⟨10.1074/jbc.M502642200⟩ Article dans une revue inserm-00318925v1
Locking the dimeric GABA(B) G-protein-coupled receptor in its active state. Julie Kniazeff,Pierre-Philippe Saintot,Cyril Goudet,Jianfeng Liu,Annie Charnetet al. Journal of Neuroscience, 2004, 24 (2), pp.370-7. ⟨10.1523/JNEUROSCI.3141-03.2004⟩ Article dans une revue hal-00319013v1
Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors. Cyril Goudet,Florence Gaven,Julie Kniazeff,Claire Vol,Jianfeng Liuet al. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (1), pp.378-83. ⟨10.1073/pnas.0304699101⟩ Article dans une revue inserm-00319003v1
Magnesium ions promote assembly of channel-like structures from beticolin o, a non-peptide fungal toxin purified from Cercospora beticola Cyril Goudet,Anne-Aliénor Véry,M.L. Milat,M. Ildefonse,Jean-Baptiste Thibaudet al. The Plant Journal, 1998, 14 (3), pp.359-364. ⟨10.1046/j.1365-313X.1998.00129.x⟩ Article dans une revue hal-02690441v1

Pré-publication, Document de travail (2)

Shedding light on left hippocampal mGlu5 in Alzheimer’s disease Charleine Zussy,Magalie Mathias,Mathieu Vitalis,Xavier Gòmez-Santacana,Cyril Goudetet al. 2025 Pré-publication, Document de travail hal-05339113v1
Conformational diversity in class C GPCR positive allosteric modulation Giuseppe Cannone,Ludovic Berto,Fanny Malhaire,Gavin Ferguson,Aurelien Fouillenet al. 2023 Pré-publication, Document de travail (preprint/prepublication) hal-04280250v1

Chapitre d'ouvrage (1)

Strategies and considerations of G-protein-coupled receptor photopharmacology Alice Berizzi,Cyril Goudet Christopher J. Langmead. From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, 88, Elsevier, pp.143-172, 2020, Advances in Pharmacology, 978-0-12-820187-9. ⟨10.1016/bs.apha.2019.12.001⟩ Chapitre d'ouvrage hal-02863838v1

Autre publication scientifique (1)

Optical activation of endogenous metabotropic glutamate receptor 4 (mGlu4) in the amygdala dynamically regulates symptoms associated with persistent inflammatory pain Charleine Zussy,X. Gomez-Santacana,Xavier Rovira,Dimitri de Bundel,S. Ferrazzoet al. 2018, pp.489-489. ⟨10.1038/mp.2018.4⟩ Autre publication scientifique hal-02448333v1