Cyril PAPAMICAEL

Publications

Article dans une revue (33)

Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core Mihaela-Liliana Ţînţaş,Ludovic Peauger,Florent Alix,Cyril Papamicaël,Thierry Bessonet al. Molecules, 2023, 28 (1), pp.36. ⟨10.3390/molecules28010036⟩ Article dans une revue hal-03922046v1
Chemical Delivery System of MIBG to the Central Nervous System: Synthesis, 11 C-Radiosynthesis, and in Vivo Evaluation Fabienne Gourand,Delphine Patin,Axelle Henry,Meźiane Ibazizeǹe,Martine Dhillyet al. ACS Medicinal Chemistry Letters, 2019, 10 (3), pp.352-357. ⟨10.1021/acsmedchemlett.8b00642⟩ Article dans une revue hal-03020265v1
Design, Synthesis, and In Vitro Biological Activities of a Bio-Oxidizable Prodrug to Deliver Both ChEs and DYRK1A Inhibitors for AD Therapy Anaïs Barré,Rabah Azzouz,Vincent Gembus,Cyril Papamicaël,Vincent Levacher Molecules, 2019, 24 (7), pp.1264. ⟨10.3390/molecules24071264⟩ Article dans une revue hal-03134351v1
Rational design of carbamate-based dual binding site and central AChE inhibitors by a “biooxidisable” prodrug approach: Synthesis, in vitro evaluation and docking studies Mihaela-Liliana Ţînţaş,Vincent Gembus,Florent Alix,Anaïs Barré,Gaël Coadouet al. European Journal of Medicinal Chemistry, 2018, 155, pp.171-182. ⟨10.1016/j.ejmech.2018.05.057⟩ Article dans une revue hal-03134356v1
Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine “bio-oxidizable” prodrugs: Synthesis, biological evaluation and structure-activity relationship Rabah Azzouz,Ludovic Peauger,Vincent Gembus,Mihaela-Liliana Tîntas,Jana Sopkova-de Oliveira Santoset al. European Journal of Medicinal Chemistry, 2018, 145, pp.165-190. ⟨10.1016/j.ejmech.2017.12.084⟩ Article dans une revue hal-02043695v1
Access to Highly Enantioenriched Donepezil-like 1,4-Dihydropyridines as Promising Anti-Alzheimer Prodrug Candidates via Enantioselective Tsuji Allylation and Organocatalytic Aza-Ene-Type Domino Reactions Mihaela-Liliana Ţînţaş,Rabah Azzouz,Ludovic Peauger,Vincent Gembus,Emilie Petitet al. Journal of Organic Chemistry, 2018, 83 (17), pp.10231-10240. ⟨10.1021/acs.joc.8b01442⟩ Article dans une revue hal-03134345v1
Dihydroquinoline Carbamate DQS1-02 as a Prodrug of a Potent Acetylcholinesterase Inhibitor for Alzheimer’s Disease Therapy: Multigram-Scale Synthesis, Mechanism Investigations, in Vitro Safety Pharmacology, and Preliminary in Vivo Toxicology Profile Florent Alix,Vincent Gembus,Laurent Coquet,Marie Hubert-Roux,Philippe Chanet al. ACS Omega, 2018, 3 (12), pp.18387-18397. ⟨10.1021/acsomega.8b02121⟩ Article dans une revue hal-03134333v1
Delivering FLT to the Central Nervous System by Means of a Promising Targeting System: Synthesis, [11C]Radiosynthesis, and in Vivo Evaluation Fabienne Gourand,Mihaela-Liliana Tîntas,Axelle Henry,Méziane Ibazizène,Martine Dhillyet al. ACS Chemical Neuroscience, 2017, 8 (11), pp.2457-2467. ⟨10.1021/acschemneuro.7b00218⟩ Article dans une revue hal-02046279v1
An Overview of the Synthesis of Highly Versatile N-Hydroxysuccinimide Esters Anaïs Barré,Mihaela-Liliana Tîntas,Vincent Levacher,Cyril Papamicaël,Vincent Gembus Synthesis: Journal of Synthetic Organic Chemistry, 2017, 49 (3), pp.472-483. ⟨10.1055/s-0036-1588607⟩ Article dans une revue hal-02046258v1
Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a “Bio-Oxidizable” Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation Ludovic Peauger,Rabah Azzouz,Vincent Gembus,Mihaela-Liliana Ţînţaş,Jana Sopkova-de Oliveira Santoset al. Journal of Medicinal Chemistry, 2017, 60 (13), pp.5909-5926. ⟨10.1021/acs.jmedchem.7b00702⟩ Article dans une revue hal-02043729v1
The Influence of Amino Group Position on Aryl Moiety of SarAr on Metal Complexation and Protein Labelling Vincent Jamier,Eskender Mume,Cyril Papamicaël,Suzanne V. Smith Australian Journal of Chemistry, 2016, 69 (9), pp.1054-1061. ⟨10.1071/CH15794⟩ Article dans une revue hal-02046216v1
Dihydroquinoline Carbamate Derivatives as &quot;Bio-oxidizable&quot; Prodrugs for Brain Delivery of Acetylcholinesterase Inhibitors: [¹¹C] Radiosynthesis and Biological Evaluation Pierre Bohn,F. Gourand,Cyril Papamicaël,M. Ibazizène,M Dhillyet al. ACS Chemical Neuroscience, 2015, 6 (5), pp.737-744. ⟨10.1021/cn5003539⟩ Article dans une revue hal-01578046v1
Palladium-Catalyzed Carbonylation of (Hetero)Aryl, Alkenyl and Allyl Halides by Means of N-Hydroxysuccinimidyl Formate as CO Surrogate Anaïs Barré,Mihaela-Liliana Tîntas,Florent Alix,Vincent Gembus,Cyril Papamicaëlet al. Journal of Organic Chemistry, 2015, 80 (13), pp.6537-6544. ⟨10.1021/acs.joc.5b01119⟩ Article dans une revue hal-02046139v1
Synthesis and Stability Evaluation of New HYNIC Derivatives as Ligands for Technetium-99m Yoann Joyard,Laurent Bischoff,Vincent Levacher,Cyril Papamicaël,Pierre Veraet al. Letters in Organic Chemistry, 2014, 11 (3), pp.208-214. ⟨10.2174/15701786113106660087⟩ Article dans une revue hal-01141349v1
New developments in redox chemical delivery systems by means of 1,4-dihydroquinoline-based targetor: Application to galantamine delivery to the brain Mihaela-Liliana Tîntas,Lénaïg Foucout,Sylvain Petit,Sylvain Oudeyer,Fabienne Gourandet al. European Journal of Medicinal Chemistry, 2014, 81, pp.218-226. ⟨10.1016/j.ejmech.2014.05.022⟩ Article dans une revue hal-01141464v1
New developments in redox chemical delivery systems by means of 1,4-dihydroquinoline-based targetor: Application to galantamine delivery to the brain Mihaela-Liliana Tîntas,Lénaïg Foucout,Sylvain Petit,Sylvain Oudeyer,Fabienne Gourandet al. European Journal of Medicinal Chemistry, 2014, 81, pp.218 - 226. ⟨10.1016/j.ejmech.2014.05.022⟩ Article dans une revue hal-03856118v1
Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds. Yoann Joyard,Rabah Azzouz,Laurent Bischoff,Cyril Papamicaël,Daniel Labaret al. Bioorganic and Medicinal Chemistry, 2013, 21 (13), pp.3680-3688. ⟨10.1016/j.bmc.2013.04.029⟩ Article dans une revue hal-00997431v1
Synthesis of sulfonic acid derivatives by oxidative deprotection of thiols using tert-butyl hypochlorite Yoann Joyard,Cyril Papamicaël,Pierre Bohn,Laurent Bischoff Organic Letters, 2013, 15 (9), pp.2294-2297. ⟨10.1021/ol400865b⟩ Article dans une revue hal-00997432v1
Synthesis and biological evaluation of a novel (99m)Tc labeled 2-nitroimidazole derivative as a potential agent for imaging tumor hypoxia. Yoann Joyard,Vadim Le Joncour,Hélène Castel,Chérif Bounana Diouf,Laurent Bischoffet al. Bioorganic and Medicinal Chemistry Letters, 2013, 23 (13), pp.3704-3708. ⟨10.1016/j.bmcl.2013.05.015⟩ Article dans une revue istex hal-00997430v1
Rational design of central selective acetylcholinesterase inhibitors by means of a &quot;bio-oxidisable prodrug&quot; strategy. Pierre Bohn,Nicolas Le Fur,Guillaume Hagues,Jean Costentin,Nicolas Torquetet al. Organic & Biomolecular Chemistry, 2009, 7 (12), pp.2612-8. ⟨10.1039/b903041g⟩ Article dans une revue istex inserm-00467214v1
A rapid synthesis of new benzene-centered porphyrin trimers. C.A. Papamicaël,O. Mongin,A. Gossauer J. Heterocyclic Chem., 2007, 44, pp.1071-1076 Article dans une revue hal-00323063v1
Synthesis of C1- and C3v-Symmetric Porphyrin Trimers Based on Triphenylmethane Cores C.A. Papamicaël,O. Mongin,A. Gossauer Chemical Monthly = Monatshefte für Chemie, 2007, 138, pp.791-796 Article dans une revue hal-00323182v1
Synthesis of C1- and C3m-Symmetric Porphyrin Trimers Based on Triphenylmethane Cores Cyril Papamicaël,Olivier Mongin,A. Gossauer Chemical Monthly = Monatshefte für Chemie, 2007, 138 (8), pp.791-796. ⟨10.1007/s00706-007-0629-y⟩ Article dans une revue istex hal-00842774v1
Preparation of new axially chiral bridged 2,2′-bipyridines and pyridyl monooxazolines (pymox). Evaluation in copper( i )-catalyzed enantioselective cyclopropanation Alexis Bouet,Barbara Heller,Cyril Papamicaël,Georges Dupas,Sylvain Oudeyeret al. Organic & Biomolecular Chemistry, 2007, 5 (9), pp.1397-1404. ⟨10.1039/b701549f⟩ Article dans une revue istex hal-02278796v1
New development of meyers' methodology : stereoselective preparation of an axially chiral 5,7-fused bicyclic lactam related to circumdatins/benzomalvins and asperlicins. M. Penhoat,Pierre Bohn,G. Dupas,C. Papamicaël,Francis Marsaiset al. Tetrahedron: Asymmetry, 2006, pp.281-6 Article dans une revue hal-00475867v1
Solid phase synthesis of a redox delivery system with the aim of targeting peptides into the brain. Claudine Patteux,Lénaïg Foucout,Pierre Bohn,Georges Dupas,Jérôme Leprinceet al. Organic & Biomolecular Chemistry, 2006, 4 (5), pp.817-25. ⟨10.1039/b516737j⟩ Article dans une revue istex inserm-00475858v1
Synthesis of Various Terphenyl Derivatives; Study of a New Amine Receptor with a Terphenyl Structure Patricia Le Nahenec-Martel,Stéphane Leleu,Francis Marsais,Cyril Papamicaël,Vincent Levacheret al. Letters in Organic Chemistry, 2005, 2 (2), pp.172-175. ⟨10.2174/1570178053202955⟩ Article dans une revue hal-02547629v1
Chemoselective, accelerated and stereoselective aza-Michael addition of amines to N-phenylmaleimide by using TMEDA based receptors Yuefeng Bi,Laëtitia Bailly,Francis Marsais,Vincent Levacher,Cyril Papamicaëlet al. Tetrahedron: Asymmetry, 2004, 15 (23), pp.3703-3706. ⟨10.1016/j.tetasy.2004.10.006⟩ Article dans une revue istex hal-02378309v1
The Inhibitor Thiomandelic Acid Binds to Both Metal Ions in Metallo-β-lactamase and Induces Positive Cooperativity in Metal Binding Christian Damblon,Mikael Jensen,Abdessamad Ababou,Igor Barsukov,Cyril Papamicaëlet al. Journal of Biological Chemistry, 2003, 278 (31), pp.29240-29251. ⟨10.1074/jbc.M301562200⟩ Article dans une revue hal-03856336v1
Three-dimensional Structure of FEZ-1, a Monomeric Subclass B3 Metallo-β-lactamase from Fluoribacter gormanii, in Native Form and in Complex with d-Captopril I Garcı́a-Sáez,P S Mercuri,Cyril Papamicaël,R Kahn,J M Frèreet al. Journal of Molecular Biology, 2003, 325, pp.651 - 660. ⟨10.1016/s0022-2836(02)01271-8⟩ Article dans une revue hal-03856347v1
The 1.5-Å structure of $Chryseobacterium\ meningosepticum$ zinc β-lactamase in complex with the inhibitor, D-Captopril Isabel García-Sáez,Julie Hopkins,Cyril Papamicaël,Nicola Franceschini,Gianfranco Amicosanteet al. Journal of Biological Chemistry, 2003, 278, pp.23868 - 23873. ⟨10.1074/jbc.m301062200⟩ Article dans une revue hal-03856326v1
Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies. C. Mollard,C. Moali,C. Papamicael,C. Damblon,S. Vessilieret al. Journal of Biological Chemistry, 2001, 276, pp.45015-45023 Article dans une revue hal-00314477v1
Thiomandelic Acid, a Broad Spectrum Inhibitor of Zinc β-Lactamases Claire Mollard,Catherine Moali,Cyril Papamicaël,Christian Damblon,Sandrine Vessilieret al. Journal of Biological Chemistry, 2001, 276 (48), pp.45015 - 45023. ⟨10.1074/jbc.m107054200⟩ Article dans une revue hal-03856340v1

Communication dans un congrès (7)

Vectorisation of [18F] radiotracers for brain tumors imaging M-L Tintas,A Henry,S Guillouet,M Ibazizène,M Dhillyet al. 5th World Congress & Expo on Pharmaceutics & Drug Delivery Systems, Feb 2020, Lisbonne, Portugal Communication dans un congrès hal-02489363v1
Vectorisation cérébrale de la [18F]FLT pour l’imagerie de gliomes de bas grade. Ml. Tintas,S. Guillouet,M. Ibazizène,M. Dhilly,F. . Fillesoyeet al. 24th Young Research Fellow Meeting in Medicinal Chemistry, Feb 2017, Châtenay-Malabry, France Communication dans un congrès hal-02320458v1
New developments for targeting drugs into central nervous system by means of a redox chemical delivery system Cyril Papamicaël Conference on organic chemistry (COC), Jun 2015, Suzhou, China Communication dans un congrès hal-02384624v1
Promising chemical delivery system into the central nervous system of [18F]FLT for PET imaging studies of low-grade brain tumours. F. Gourand,A. Henry,M. Ibazizene,M. Dhilly,Cyril Papamicaëlet al. Annual Congress of the European-Association-of-Nuclear-Medicine (EANM, 28, 2015), Oct 2015, Hambourg, Germany. pp.476-477 Communication dans un congrès hal-02024980v1
New Developments for Targeting Drugs into Central Nervous System by Means of a Redox Chemical Delivery System C Papamicaël,V Levacher,F Gourand,L Barré International Conference on Organic Chemistry, Jun 2015, ShanghaÏ, China Communication dans un congrès hal-02488939v1
Synthesis of Technidazole: a potential new 99mTc ligand for imaging tumor hypoxia Yoann Joyard,Pierre Bohn,Cyril Papamicaël,Vincent Levacher,Pierre Vera Annual Congress of the European Association of Nuclear Medicine, 2012, Milan, Italy Communication dans un congrès hal-01154357v1
Synthèse de radiomarqueurs technétiés et fluorés pour la détection de cellules hypoxiques tumorales Y. Joyard,R. Azzouz,C. Fruit,L. Bischoff,C. Papamicaelet al. 4èmes journées scientifiques du cancéropôle nord-ouest, May 2011, Deauville, France Communication dans un congrès hal-00673945v1

Poster de conférence (8)

Transport into the central nervous system of [18F]FLT and [18F]Fludarabine for brain tumors M-L Tintas,S Guillouet,M Ibazizène,F Fillesoye,C Papamicaëlet al. 4th Nuclear Technologies for Health Symposium, NTHS2020, Feb 2020, Nantes, France Poster de conférence hal-02487617v1
Transport into the central nervous system of [18F]FLT and [18F]Fludarabine for brain tumors Mihaela-Liliana Tîntas,S Guillouet,Méziane Ibazizène,Fabien Fillesoye,C. Papamicaëlet al. 23rd International Symposium on Radiopharmaceutical Sciences, May 2019, Beijing, China Poster de conférence hal-02374599v1
Development of new redox chemical delivery systems for targeting radiotracers into the brain A Henry,C Papamicaël,D Patin,F Gourand,L Barréet al. Journée de l’Ecole Doctorale Normande de Chimie (JEDNC), Jun 2016, Caen, France Poster de conférence hal-02386584v1
New redox chemical delivery systems to target radiotracers into the brain A Henry,P Papamicaël,D Patin,F Gourand,L Barréet al. 52èmes Rencontres Internationales de Chimie Thérapeutique, Jul 2016, Caen, France Poster de conférence hal-02386568v1
Dihydroquinoline derivatives as redox chemical delivery systems (CDS) or “bio-oxidisable” prodrugs for brain delivery of acetylcholinesterase inhibitors: design, synthesis, [11C]radiosynthesis and biological evaluation P Bohn,F Gourand,C Papamicaël,M Ibazizène,M Dhillyet al. Journées Neurosciences, Workshop FLI, Nov 2015, Orsay, France Poster de conférence hal-02386737v1
Promising chemical delivery system into the central nervous system of [18F]FLT for PET imaging studies of low-grade brain tumours F Gourand,A Henry,M Ibazizène,M Dhilly,C Papamicaëlet al. Congrès EANM15, Oct 2015, Hambourg, Germany Poster de conférence hal-02386810v1
Development of redox chemical delivery systems for targeting radiotracers in central nervous system A Henry,C Papamicaël,V Levacher,D Patin,F Gourandet al. Journées Nord-Ouest Européennes des Jeunes Chercheurs (JNOEJC), May 2015, Rouen, France Poster de conférence hal-02386797v1
Dihydroquinoline derivatives as redox chemical delivery systems (CDS) or “bio-oxidisable” prodrugs for brain delivery of acetylcholinesterase inhibitors : design, synthesis, [11C] radiosynthesis and biological evaluation P Bohn,F Gourand,C Papamicaël,M Ibazizène,M Dhillyet al. XVI International Conference on Heterocycles in Bioorganic Chemistry, Jun 2015, Metz, France Poster de conférence hal-02386824v1