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Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging

Dorian Ziegler , David Vindrieux , Delphine Goehrig , Sara Jaber , Guillaume Collin , et al.
Nature Communications, 2021, 12 (1), pp.720. ⟨10.1038/s41467-021-20993-z⟩
Article dans une revue hal-04277344v1
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Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging

D. V. Ziegler , D. Vindrieux , D. Goehrig , S. Jaber , Guillaume Collin , et al.
Nature Communications, 2021, 12 (1), pp.720. ⟨10.1038/s41467-021-20993-z⟩
Article dans une revue inserm-03282710v1
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Regulation of cellular senescence by retinoid X receptors and their partners

Nadine Martin , Xingjie Ma , David Bernard
Mechanisms of Ageing and Development, 2019, 183, pp.111131. ⟨10.1016/j.mad.2019.111131⟩
Article dans une revue hal-02323512v1
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Hepatic Stellate Cell Senescence in Liver Tumorigenesis

Nadine Martin , Dorian Ziegler , Romain Parent , David Bernard
Hepatology, In press, ⟨10.1002/hep.31556⟩
Article dans une revue hal-03008992v1
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Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1

Sara Jaber , Delphine Goehrig , Philippe Bertolino , Amélie Massemin , Franck Bihl , et al.
Scientific Reports, 2020, 10 (1), pp.8190. ⟨10.1038/s41598-020-64863-y⟩
Article dans une revue inserm-02865473v1
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Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters

Lou Delval , Aline Hantute-Ghesquier , Valentin Sencio , Jean Michel Flaman , Cyril Robil , et al.
Nature Aging, 2023, 3 (7), pp.829-845. ⟨10.1038/s43587-023-00442-w⟩
Article dans une revue inserm-04170802v1

Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape

C. Wiel , Baptiste Gras , David Vindrieux , Marine Warnier , Delphine Gitenay , et al.
Oncogene, 2016, 35 (12), pp.1596-1601. ⟨10.1038/onc.2015.218⟩
Article dans une revue hal-03144216v1

MUC1 drives epithelial–mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter

Viviane Gnemmi , Audrey Bouillez , Kelly Gaudelot , Brigitte Hémon , Bélinda Ringot , et al.
Cancer Letters, 2014, 346 (2), pp.225-236. ⟨10.1016/j.canlet.2013.12.029⟩
Article dans une revue hal-03313770v1

The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice

Marielle Breau , Amal Houssaini , Larissa Lipskaia , Shariq Abid , Emmanuelle Born , et al.
JCI Insight, 2019, 4 (19), ⟨10.1172/jci.insight.127647⟩
Article dans une revue hal-02438202v1
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Depletion of preexisting B‐cell lymphoma 2‐expressing senescent cells before vaccination impacts antigen‐specific antitumor immune responses in old mice

Ozmen Cobanoglu , Lou Delval , Daniele Ferrari , Lucie Deruyter , Séverine Heumel , et al.
Aging Cell, 2023, 22 (12), pp.e14007. ⟨10.1111/acel.14007⟩
Article dans une revue hal-04373734v1
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Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema

Alberta Palazzo , Gabriela Makulyte , Delphine Goerhig , Jean-Jacques Médard , Vincent Gros , et al.
Aging (Albany N.Y.), 2023
Article dans une revue hal-04373654v1
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Regulation and role of calcium in cellular senescence

Nadine Martin , Kexin Zhu , Joanna Czarnecka-Herok , Mathieu Vernier , David Bernard
Cell Calcium, 2023, 110, pp.102701. ⟨10.1016/j.ceca.2023.102701⟩
Article dans une revue hal-04113402v1

Cholesterol biosynthetic pathway induces cellular senescence through ERRα

Dorian Ziegler , Mathieu Vernier , Joanna Czarnecka-Herok , Charlotte Scholtes , Christelle Machon , et al.
2022
Pré-publication, Document de travail hal-03516375v1
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The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes

Audrey Griveau , Clotilde Wiel , Dorian Ziegler , Martin Bergo , David Bernard
Aging Cell, 2020, 19 (4), ⟨10.1111/acel.13122⟩
Article dans une revue hal-03009024v1

ORP5 Transfers Phosphatidylserine To Mitochondria And Regulates Mitochondrial Calcium Uptake At Endoplasmic Reticulum - Mitochondria Contact Sites

Leila Rochin , Cécile Sauvanet , Eeva Jääskeläinen , Audrey Houcine , Annukka Kivelä , et al.
BioRxiv, 2020, pp.695577. ⟨10.1101/695577⟩
Article dans une revue hal-03128735v1
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PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging

Anda Huna , Audrey Griveau , David Vindrieux , Sara Jaber , Jean-Michel Flaman , et al.
Cell Death and Disease, 2021, 12 (2), pp.190. ⟨10.1038/s41419-021-03468-3⟩
Article dans une revue inserm-03420490v1
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Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence

D Gitenay , C Wiel , H Lallet-Daher , D Vindrieux , S. Aubert , et al.
Cell Death and Disease, 2014, 5 (2), pp.e1089-e1089. ⟨10.1038/cddis.2014.63⟩
Article dans une revue hal-03108285v1
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Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth

David Vindrieux , Guillaume Devailly , Arnaud Augert , Benjamin Le Calvé , Mylène Ferrand , et al.
Oncotarget, 2014, 5 (4), pp.1004-1013. ⟨10.18632/oncotarget.1681⟩
Article dans une revue hal-01867980v1
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Le traitement antioxydant protège contre l’emphysème mais favorise la survenue et la progression du cancer du poumon

Marielle Breau , David Bernard , Fatima Mechta-Grigoriou , Serge Adnot
Médecine/Sciences, 2020, 36 (3), pp.200-203. ⟨10.1051/medsci/2020030⟩
Article dans une revue hal-02903958v1
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Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors

Ikrame Naciri , Marthe Laisné , Laure Ferry , Morgane Bourmaud , Nikhil Gupta , et al.
Nucleic Acids Research, 2019, 47 (7), pp.3407-3421. ⟨10.1093/nar/gkz080⟩
Article dans une revue pasteur-02071691v1
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Expression of the Calcium-Binding Protein CALB1 Is Induced and Controls Intracellular Ca2+ Levels in Senescent Cells

Clotilde Raynard , Nolwenn Tessier , Anda Huna , Marine Warnier , Jean-Michel Flaman , et al.
International Journal of Molecular Sciences, 2022, 23 (16), pp.9376. ⟨10.3390/ijms23169376⟩
Article dans une revue hal-03854772v1

The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway

Marine Warnier , Jean-Michel Flaman , Christophe Chouabe , Clotilde Wiel , Baptiste Gras , et al.
Aging Cell, 2018, 17 (3), pp.e12736. ⟨10.1111/acel.12736⟩
Article dans une revue hal-01847501v1

PLA2R1 Mediates Tumor Suppression by Activating JAK2

David Vindrieux , Arnaud Augert , Christophe Girard , Delphine Gitenay , Helene Lallet-Daher , et al.
Cancer Research, 2013, 73 (20), pp.6334-6345. ⟨10.1158/0008-5472.CAN-13-0318⟩
Article dans une revue hal-02395807v1

The PLA2R1-JAK2 pathway upregulates ERRα and its mitochondrial program to exert tumor-suppressive action

A Griveau , Guillaume Devailly , G Devailly , L Eberst , N Navaratnam , et al.
Oncogene, 2016, 35 (38), pp.5033-5042. ⟨10.1038/onc.2016.43⟩
Article dans une revue hal-01868807v1

Evidence that SARS-CoV-2 Induces Lung-Cell Senescence: Potential Impact on COVID-19 Lung Disease

Larissa Lipskaia , Pauline Maisonnasse , Charles Fouillade , Valentin Sencio , Quentin Pascal , et al.
American Journal of Respiratory Cell and Molecular Biology, In press, ⟨10.1165/rcmb.2021-0205LE⟩
Article dans une revue hal-03411265v1
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RSK3 switches cell fate: from stress-induced senescence to malignant progression

Anda Huna , Jean-Michel Flaman , Catalina Lodillinsky , Kexin Zhu , Gabriela Makulyte , et al.
Journal of experimental & clinical cancer research, 2023, 42, pp.318. ⟨10.1186/s13046-023-02909-5⟩
Article dans une revue hal-04373725v1

Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A

Yajie Zhao , Zhichong Wu , Marie Chanal , Fabienne Guillaumond , Delphine Goehrig , et al.
Cancer Research, 2020, 80 (16), pp.3359-3371. ⟨10.1158/0008-5472.CAN-19-3763⟩
Article dans une revue hal-03008999v1
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Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy

Sara Jaber , Marine Warnier , Christopher Leers , Mathieu Vernier , Delphine Goehrig , et al.
Molecular Biomedicine, 2023, 4 (1), pp.4. ⟨10.1186/s43556-023-00116-4⟩
Article dans une revue hal-04113411v1
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Elimination of Senescent Endothelial Cells: Good or Bad Idea?

Nadine Martin , Anda Huna , David Bernard
Trends in Cell Biology, 2021, 31 (5), pp.327-330. ⟨10.1016/j.tcb.2021.02.009⟩
Article dans une revue inserm-03420580v1
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Extracellular AGR2 triggers lung tumour cell proliferation through repression of p21(CIP1)

Delphine Fessart , Claire de Barbeyrac , Ines Boutin , Thomas Grenier , Elodie Richard , et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 2021, 1868 (3), pp.118920. ⟨10.1016/j.bbamcr.2020.118920⟩
Article dans une revue hal-03102260v1