David Godefroy

Publications

Article dans une revue (40)

Molecular determinants of cardiac lymphatic dysfunction in a chronic pressure-overload model Coraline Heron,Theo Lemarcis,Océane Laguerre,Bénjamin Bourgeois,Corentin Thuilliezet al. EMBO Molecular Medicine, 2026, 18 (1), pp.325-355. ⟨10.1038/s44321-025-00345-w⟩ Article dans une revue hal-05460672v1
Whole body distribution of the regulatory peptide 26RFa in male and female mice Marie Picot,Mélodie Devère,Saloua Takhlidjt,Corentin Guillemot,Caroline Lusurieret al. Peptides, 2025, 190, pp.171417. ⟨10.1016/j.peptides.2025.171417⟩ Article dans une revue (data paper) hal-05326224v1
Molecular determinants of cardiac lymphatic dysfunction in a chronic pressure-overload model Coraline Heron,Theo Lemarcis,Océane Laguerre,Bénjamin Bourgeois,Corentin Thuilliezet al. EMBO Molecular Medicine, 2025, 18 (1), pp.325-355. ⟨10.1038/s44321-025-00345-w⟩ Article dans une revue hal-05485217v1
Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells Lisa Brunet,David Alexandre,Jiyoung Lee,Maria del Mar Blanquer-Rosselló,David Bracquemondet al. Nature Communications, 2025, 16, pp.7853. ⟨10.1038/s41467-025-61788-w⟩ Article dans une revue hal-05292896v1
Central SELENOT deficiency impairs gonadotrope axis function, sexual behavior and fertility in male and female mice Ben Yamine Mallouki,Loubna Boukhzar,Ludovic Dumont,Azénor Abgrall,Marjorie Graset al. JCI Insight, 2025, 10 (24), pp.e189775. ⟨10.1172/jci.insight.189775⟩ Article dans une revue hal-05397502v1
SELENOPROTEIN T deficiency alters projection neuron migration during corticogenesis in mice Emmanuelle Carpentier,Anthony Falluel-Morel,Lisa Brunet,Magalie Bénard,David Alexandreet al. Neuroscience, 2025, 585, pp.323-334. ⟨10.1016/j.neuroscience.2025.09.015⟩ Article dans une revue hal-05326228v1
The urotensin II receptor triggers an early meningeal response and a delayed macrophage-dependent vasospasm after subarachnoid hemorrhage in male mice Martin Pedard,Lucie Prevost,Camille Carpena,Brian Holleran,Laurence Desrueset al. Nature Communications, 2024, 15 (1), pp.8430. ⟨10.1038/s41467-024-52654-2⟩ Article dans une revue hal-04766828v1
Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury Heidi A. Creed,Saranya Kannan,Brittany L. Tate,David Godefroy,Priyanka Banerjeeet al. Journal of the American Society of Nephrology, 2024, 35 (5), pp.549-565. ⟨10.1681/ASN.0000000000000325⟩ Article dans une revue hal-05155866v1
SELENOT deficiency in the mouse brain impacts catecholaminergic neuron density: an immunohistochemical, in situ hybridization and 3D light-sheet imaging study David Godefroy,Loubna Boukhzar,Ben Yamine Mallouki,Emmanuelle Carpentier,Christophe Dubessyet al. Neuroendocrinology, 2023, 113 (2), pp.193-207. ⟨10.1159/000522091⟩ Article dans une revue hal-03666802v1
Regulation and impact of cardiac lymphangiogenesis in pressure-overload-induced heart failure Coraline Heron,Anais Dumesnil,Mahmoud Houssari,Sylvanie Renet,Theo Lemarciset al. Cardiovascular Research, 2023, 119 (2), pp.492-505. ⟨10.1093/cvr/cvac086⟩ Article dans une revue (data paper) inserm-04113422v1
Cell-penetrating, antioxidant SELENOT mimetic protects dopaminergic neurons and ameliorates motor dysfunction in Parkinson's disease animal models Ifat Alsharif,Loubna Boukhzar,Benjamin Lefranc,David Godefroy,Juliette Aury-Landaset al. Redox Biology, 2021, 40, pp.101839. ⟨10.1016/j.redox.2020.101839⟩ Article dans une revue hal-03132187v1
Lymphatic and Immune Cell Cross-Talk Regulates Cardiac Recovery After Experimental Myocardial Infarction Mahmoud Houssari,Anais Dumesnil,Virginie Tardif,Riikka Kivelä,Nathalie Pizzinatet al. Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, 40 (7), pp.1722-1737. ⟨10.1161/ATVBAHA.120.314370⟩ Article dans une revue hal-03553406v1
Three-dimensional mapping of tyrosine hydroxylase in the transparent brain and adrenal of prenatal and pre-weaning mice: Comprehensive methodological flowchart and quantitative aspects of 3D mapping David Godefroy,Loubna Boukhzar,Christophe Dubessy,Maïté Montero-Hadjadje,Laurent Yonet al. Journal of Neuroscience Methods, 2020, 335, pp.108596. ⟨10.1016/j.jneumeth.2020.108596⟩ Article dans une revue hal-02485649v1
Glucose homeostasis is impaired in mice deficient in the neuropeptide 26RFa (QRFP) Mouna El-Mehdi,Saloua Takhlidjt,Fayrouz Khiar,Gaëtan Prévost,Jean-Luc Do Regoet al. BMJ Open Diab Res Care, 2020, 8 (1), pp.2019-000942. ⟨10.1136/bmjdrc-2019-000942⟩ Article dans une revue hal-02884077v1
Tyrosine-hydroxylase immunoreactivity in the mouse transparent brain and adrenal glands David Godefroy,William Rostène,Youssef Anouar,Annabelle Reaux-Le Goazigo Journal of Neural Transmission, 2018 Article dans une revue hal-01944579v1
Cone degeneration is triggered by the absence of USH1 proteins but prevented by antioxidant treatments Alix Trouillet,Elisabeth Dubus,Julie Degardin,Amrit Estivalet,Ivana Ivkovicet al. Scientific Reports, 2018, 8 (1), pp.1968. ⟨10.1038/s41598-018-20171-0⟩ Article dans une revue hal-01708801v1
Hyperosmolarity and Benzalkonium Chloride Differently Stimulate Inflammatory Markers in Conjunctiva-Derived Epithelial Cells in vitro Elise Warcoin,Chloé Clouzeau,Christophe Roubeix,Anne-Laure Raveu,David Godefroyet al. Ophthalmic Research, 2017, 58 (1), pp.40-48 Article dans une revue hal-01945327v1
Tridimensional Visualization and Analysis of Early Human Development Morgane Belle,David Godefroy,Gérard Couly,Samuel A. Malone,Francis Collieret al. Cell, 2017, 169 (1), pp.161-173.e12. ⟨10.1016/j.cell.2017.03.008⟩ Article dans une revue hal-01497677v1
Ocular inflammation induces trigeminal pain, peripheral and central neuroinflammatory mechanisms Pierre-Serge Launay,Elodie Reboussin,Hong Liang,Karima Kessal,David Godefroyet al. Neurobiology of Disease, 2016, 88, pp.16-28. ⟨10.1016/j.nbd.2015.12.017⟩ Article dans une revue hal-01258703v1
Bilateral neuroinflammatory processes in visual pathways induced by unilateral ocular hypertension in the rat Anaïs Sapienza,Anne-Laure Raveu,Elodie Reboussin,Christophe Roubeix,Céline Boucheret al. Journal of Neuroinflammation, 2016, 13 (1), pp.44. ⟨10.1186/s12974-016-0509-7⟩ Article dans une revue hal-01282014v1
Bilateral neuroinflammatory processes in visual pathways induced by unilateral ocular hypertension in the rat Anaïs Sapienza,Anne-Laure Raveu,Elodie Reboussin,Christophe Roubeix,Céline Boucheret al. Journal of Neuroinflammation, 2016, 13 (1) Article dans une revue hal-01945066v1
Combined 3DISCO clearing method, retrograde tracer and ultramicroscopy to map corneal neurons in a whole adult mouse trigeminal ganglion Pierre-Serge Launay,David Godefroy,Hanen Khabou,William Rostene,José-Alain Sahelet al. Experimental Eye Research, 2015, 139, pp.136-143. ⟨10.1016/j.exer.2015.06.008⟩ Article dans une revue hal-01172713v1
Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma Christophe Roubeix,David Godefroy,Céline Mias,Anaïs Sapienza,Luisa Rianchoet al. Current Stem Cell Research & Therapy, 2015, 6 (1), pp.177. ⟨10.1186/s13287-015-0168-0⟩ Article dans une revue hal-01202543v1
Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma Christophe Roubeix,David Godefroy,Céline Mias,Anaïs Sapienza,Luisa Rianchoet al. Current Stem Cell Research & Therapy, 2015, 6 (1), pp.177. ⟨10.1186/s13287-015-0168-0⟩ Article dans une revue hal-01945084v1
À l’intérieur du tissu cérébral Alzheimer avec la méthode CLARITY : plaques séniles, dégénérescences neurofibrillaires et axones en 3D Kunie Ando,Laborde Quentin,David Godefroy,Benoit Delatour,Charles Duyckaerts Morphologie, 2015, 99 (326), pp.96-97 Article dans une revue hal-01946787v1
Inside Alzheimer brain with CLARITY: senile plaques, neurofibrillary tangles and axons in 3-D Kunie Ando,Quentin Laborde,Adina Lazar,David Godefroy,Ihsen Youssefet al. Acta Neuropathologica, 2014, 128 (3), pp.457-459. ⟨10.1007/s00401-014-1322-y⟩ Article dans une revue hal-01944638v1
A Simple Method for 3D Analysis of Immunolabeled Axonal Tracts in a Transparent Nervous System Morgane Belle,David Godefroy,Chloé Dominici,Céline Heitz-Marchaland,Pavol Zelinaet al. Cell Reports, 2014, 9 (4), pp.1191-1201. ⟨10.1016/j.celrep.2014.10.037⟩ Article dans une revue hal-01083957v1
Inside Alzheimer brain with CLARITY: senile plaques, neurofibrillary tangles and axons in 3-D Kunie Ando,Quentin Laborde,Adina Lazar,David Godefroy,Ihsen Youssefet al. Acta Neuropathologica, 2014, 128 (3), pp.457-459. ⟨10.1007/s00401-014-1322-y⟩ Article dans une revue hal-03572608v1
Effects of Methylmercury Contained in a Diet Mimicking the Wayana Amerindians Contamination through Fish Consumption: Mercury Accumulation, Metallothionein Induction, Gene Expression Variations, and Role of the Chemokine CCL2 Jean-Paul Bourdineaud,Muriel N. Laclau,Régine Maury-Brachet,Patrice Gonzalez,Magalie Baudrimontet al. International Journal of Molecular Sciences, 2012, 13 (6), pp.7710-7738 Article dans une revue hal-01945289v1
CXCR3 Antagonism of SDF-1(5-67) Restores Trabecular Function and Prevents Retinal Neurodegeneration in a Rat Model of Ocular Hypertension Alexandre Denoyer,David Godefroy,Isabelle Célérier,Julie Frugier,Julie Degardinet al. PLoS ONE, 2012, 7 (6), pp.e37873. ⟨10.1371/journal.pone.0037873⟩ Article dans une revue hal-01944693v1
Blockade of the chemokine receptor CXCR3 lowers intraocular pressure and prevents retinal degeneration in an animal model of glaucoma Alexandre Denoyer,Frugier Julie,David Godefroy,Julie Degardin,Francoise Brignole-Baudouinet al. Acta Ophthalmologica Scandinavica -Supplement-, 2012, 90 Article dans une revue hal-01946808v1
Hyperosmolarity potentiates toxic effects of benzalkonium chloride on conjunctival epithelial cells in vitro Chloé Clouzeau,David Godefroy,Luisa Riancho,William Rostene,Christophe Baudouinet al. Molecular Vision, 2012, 18, pp.851-863 Article dans une revue hal-01945322v1
The chemokine CCL2 protects against methylmercury neurotoxicity. David Godefroy,Romain-Daniel Gosselin,Akira Yasutake,Masatake Fujimura,Christophe Combadièreet al. Review of Economic Dynamics, 2012, 125 (1), pp.209-18. ⟨10.1093/toxsci/kfr252⟩ Article dans une revue inserm-00630697v1
Effects of Methylmercury Contained in a Diet Mimicking the Wayana Amerindians Contamination through Fish Consumption: Mercury Accumulation, Metallothionein Induction, Gene Expression Variations, and Role of the Chemokine CCL2. Jean-Paul Bourdineaud,Muriel Laclau,Régine Maury-Brachet,Patrice Gonzalez,Magalie Baudrimontet al. International Journal of Molecular Sciences, 2012, 13 (6), pp.7710-38. ⟨10.3390/ijms13067710⟩ Article dans une revue hal-00749442v1
NaCl-induced hyperosmotic stress as an in vitro dry eye model potentiated by synergic toxic effects of Benzalkonium chloride on conjunctival epithelial cells Chloé Clouzeau,David Godefroy,Luisa Riancho,William Rostene,Christophe Baudouinet al. Toxicology Letters, 2011, 205, pp.S155 Article dans une revue hal-01946821v1
Implication of CCR2 Chemokine Receptor in Cocaine-Induced Sensitization Jean Marc Trocello,William Rostène,Stéphane Melik-Parsadaniantz,David Godefroy,Emmanuel Rozeet al. Journal of Molecular Neuroscience, 2011, 44 (3), pp.147-151 Article dans une revue hal-01945340v1
Neurochemokines: a menage a trois providing new insights on the functions of chemokines in the central nervous system William Rostène,Marc-André Dansereau,David Godefroy,Juliette van Steenwinckel,Annabelle Reaux-Le Goazigoet al. Journal of Neurochemistry, 2011, 118 (5), pp.680-694 Article dans une revue hal-01944671v1
Chemokines and chemokine receptors: New actors in neuroendocrine regulations William Rostène,Alice Guyon,Lara Kular,David Godefroy,Federica Barbieriet al. Frontiers in Neuroendocrinology, 2011, 32 (1), pp.10-24 Article dans une revue hal-01944623v1
CX3CL1 is involved in the ocular surface inflammation induced by benzalkonium chloride Alexandre Denoyer,David Godefroy,Julie Frugier,Francoise Brignole-Baudouin,William Rosteneet al. Acta Ophthalmologica Scandinavica -Supplement-, 2010, 88 Article dans une revue hal-01946832v1
Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons Masatake Fujimura,Fusako Usuki,William Rostene,David Godefroy,Masumi Sawadaet al. NeuroToxicology, 2009, 30 (1), pp.16-22 Article dans une revue hal-01945199v1

Pré-publication, Document de travail (1)

Molecular determinants of cardiac lymphatic dysfunction in a chronic pressure-overload model C. Heron,T. Lemarcis,O. Laguerre,B. Bourgeois,C Thuilliezet al. 2026 Pré-publication, Document de travail hal-05015428v1

Poster de conférence (12)

Whole body distribution of the regulatory peptide 26RFa in male and female mice David Godefroy,Marie Picot,Mélodie Devère,Saloua Takhlidjt,Corentin Guillemotet al. 47th conference of the Society of Neuroendocrinology, Oct 2025, Lausanne ( CH), Switzerland Poster de conférence hal-05326310v1
Expression et localisation de deux neuropeptides de la famille des RF-amides, Kp10 et 26RFa, et leurs récepteurs dans le testicule murin au cours de la première vague de la spermatogenèse Magali Basille-Dugay,Laura Moutard,Frédérique Bateux,David Godefroy,Saloua Takhlidjtet al. Journée Normande de Recherche Biomédicale, Jun 2024, Rouen, France. 2024 Poster de conférence hal-05165636v1
Senescence of POMC Neurons Induced by SELENOT Deprivation Enhances Neurosecretory Activity Cédric Jehan,Dorthe Cartier,Christine Bucharles,Philippe Chan,David Godefroyet al. 45ème Colloque de La Société de Neuroendocrinologie, Sep 2023, Rouen, France. 2023 Poster de conférence hal-05325973v1
To Help You Make “Transparisation” an Effective Tool Romina D’Angelo,Laurence Dubreil,David Godefroy,Chloé Chaumeton,Matthieu Simionet al. Ecole thématique “Functional Microscopy for Biology” (MiFoBio), Nov 2023, Presqu’île de Giens, France Poster de conférence hal-04917715v1
A Working Group to Help you Make « Transparisation » / Clearing an Effective Tool Romina D’Angelo,Katia Belcram,Laurence Dubreil,Chloé Chaumeton,Matthieu Simionet al. Alternative Models to Animal Testing - 1st GSO Workshop, May 2023, Toulouse - Hôtel de Région, France Poster de conférence hal-04917388v1
Interactions neurones-cellules de gliome dans les processus d'invasion de la substance blanche, dans un modèle préclinique de glioblastome Quentin Lemercier,Laurence Desrues,David Godefroy,Alexis Lebon,Lucie Martinet al. Cancéropôle Nord-Ouest, May 2023, Deauville, France. 2023 Poster de conférence hal-05168189v1
To Help You Make “Transparisation” an Effective Tool Laurence Dubreil,Katia Belcram,Cholé Chaumeton,Romina d'Angelo,David Godefroyet al. JST RMUI, Nov 2022, Rennes, France Poster de conférence hal-03922305v1
Neuron-Glioma Interactions in White Matter Invasion in a Preclinical Model of Glioblastoma Quentin Lemercier,Alexis Lebon,Laurence Desrues,David Godefroy,Lucie Martinet al. Journée Normande de Recherche Biomédicale, Jun 2022, Rouen, France. 2022 Poster de conférence hal-05164773v1
Tridimensional Analysis of Catecholaminergic Neuron Distribution in Selenot-Deficience Mice David Godefroy,Ben Yamine Mallouki,Loubna Boukhzar,Emmanuelle Carpentier,Yves Tilletet al. Journée Normande de Recherche Biomédicale, Jun 2022, Rouen, France. 2022 Poster de conférence hal-05164770v1
Neuron-Glioma Interactions in White Matter Invasion, in a Preclinical Model of Glioblastoma Quentin Lemercier,Laurence Desrues,David Godefroy,Alexis Lebon,Lucie Martinet al. Congrès Annuel de l'ACOCEF, Jul 2022, Rouen, France. 2022 Poster de conférence hal-05164772v1
A Working Group to Help You Make &quot;Transparisation&quot; an Effective Tool Romina D’Angelo,Katia Belcram,Cholé Chaumeton,Laurence Dubreil,David Godefroyet al. 18èmes Journées Annuelles du Cancéropôle Grand Sud-Ouest, Nov 2022, La Grande Motte, France. Poster de conférence hal-04919990v1
Evidences of early astroglial reactivity associated with glioma invasion in a preclinical model of glioblastoma Quentin Lemercier,Laurence Desrues,David Godefroy,Pierrick Gandolfo,Hélène Castelet al. 23th annual meeting of the LARC-Neuroscience network, Oct 2019, Nantes, France Poster de conférence hal-02452583v1

Communication dans un congrès (6)

Le RNAscope® : une solution d'imagerie de l'ARN Marie Picot,David Godefroy Conférence IRIB, Feb 2024, Rouen, France Communication dans un congrès hal-05163709v1
Glucose Homeostasis and Energy Metabolism Are Impaired in Orexins Deficient Mice Mélodie Devère,Saloua Takhlidjt,Jean-Luc Do Rego,Jean-Claude Do Rego,Alexandre Benaniet al. 46. colloque de la Société de Neuroendocrinologie (SNE), Sep 2024, Nice, France Communication dans un congrès hal-05163697v1
Transparisation et imagerie 3D du sphéroide à l'organisme entier, chez l'animal et/ou le végétal David Godefroy ONIRIS, Oct 2024, Nantes, France Communication dans un congrès hal-05163704v1
The urotensin II receptor relays key neurobiological mechanisms in subarachnoid hemorrhage: Efficacy of pathway-targeted drugs on long-term brain deficits Martin Pedard,Martine Dubois,Roxane Gruel,Laurence Desrues,David Godefroyet al. Congrès annuel du GDR-GPCR, Oct 2019, Montpellier, France Communication dans un congrès hal-02418166v1
The urotensin II receptor relays key neurobiological mechanisms in subarachnoid hemorrhage: Efficacy of pathway-targeted drugs on early meningeal damages and long-term brain deficits Martin Pedard,Martine Dubois,Roxane Gruel,Laurence Desrues,David Godefroyet al. LARC-Neuroscience network, Oct 2019, Nantes, France Communication dans un congrès hal-02418192v1
Transparisation et imagerie des échantillons biologiques, quelle méthode? Quelle application? Laurence Dubreil,Orestis Faklaris,Romina d'Angelo,Thomas Guilbert,David Godefroy 15ème assises Nationales des plateformes d'imagerie cellulaire du RTMFM, Plate-Forme Régionale de Recherche en Imagerie Cellulaire de Haute-Normandie (PRIMACEN). FRA., Mar 2018, Rouen, France Communication dans un congrès hal-01869883v1

Thèse (1)

Caractérisation des neurones exprimant la tyrosine hydroxylase chez les souris sauvages et invalidées pour la SELENOT : imagerie tridimensionnelle et analyse comportementale David Godefroy Médecine humaine et pathologie. Normandie Université, 2022. Français. ⟨NNT : 2022NORMR050⟩ Thèse tel-04033792v1