David Pastre

Publications

Article dans une revue (57)

TDP-43 nuclear retention is antagonized by hypo-phosphorylation of its C-terminus in the cytoplasm Célia Rabhi,Nicolas Babault,Céline Martin,Bénédicte Desforges,Alexandre Maucueret al. Communications Biology, 2025, 8 (1), pp.136. ⟨10.1038/s42003-025-07456-7⟩ Article dans une revue hal-04918699v1
RNA and the RNA-binding protein FUS act in concert to prevent TDP-43 spatial segregation Clément Demongin,Samuel Tranier,Vandana Joshi,Léa Ceschi,Bénédicte Desforgeset al. Journal of Biological Chemistry, 2024, pp.105716. ⟨10.1016/j.jbc.2024.105716⟩ Article dans une revue hal-04455540v1
Using the structural diversity of RNA: protein interfaces to selectively target RNA with small molecules in cells: methods and perspectives Aixiao Li,Ahmed Bouhss,Marie-Jeanne Clément,Cyril Bauvais,J. Paul Tayloret al. Frontiers in Molecular Biosciences, 2023, 10, ⟨10.3389/fmolb.2023.1298441⟩ Article dans une revue hal-04485882v1
FUS RRM regulates poly(ADP-ribose) levels after transcriptional arrest and PARP-1 activation on DNA damage Evgeniya Mamontova,Marie-Jeanne Clément,Maria Sukhanova,Vandana Joshi,Ahmed Bouhsset al. Cell Reports, 2023, 42 (10), pp.113199. ⟨10.1016/j.celrep.2023.113199⟩ Article dans une revue hal-04231448v1
p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress Binita Goswami,Deepika Ahuja,David Pastré,Partho Sarothi Ray Communications Biology, 2023, 6 (1), pp.110. ⟨10.1038/s42003-023-04507-9⟩ Article dans une revue hal-04231533v1
FUS fibrillation occurs through a nucleation-based process below the critical concentration required for liquid–liquid phase separation Emilie Bertrand,Clément Demongin,Ioana Dobra,Juan-Carlos Rengifo-Gonzalez,Anastasia S Singatulinaet al. Scientific Reports, 2023, 13 (1), pp.7772. ⟨10.1038/s41598-023-34558-1⟩ Article dans une revue hal-04231423v1
Targeting RNA:protein interactions with an integrative approach leads to the identification of potent YBX1 inhibitors Krystel El Hage,Nicolas Babault,Olek Maciejak,Bénédicte Desforges,Pierrick Craveuret al. eLife, 2023, 12, pp.e80387. ⟨10.7554/eLife.80387⟩ Article dans une revue hal-03955052v1
PARP1 Activation Controls Stress Granule Assembly after Oxidative Stress and DNA Damage Anastasia S Singatulina,Maria V Sukhanova,Benedicte Desforges,Vandana Joshi,David Pastreet al. Cells, 2022, 11 (23), pp.3932 Article dans une revue hal-04584419v1
FUS Microphase Separation: Regulation by Nucleic Acid Polymers and DNA Repair Proteins Maria V Sukhanova,Rashid O Anarbaev,Ekaterina A Maltseva,D Pastre,Olga I Lavrik International Journal of Molecular Sciences, 2022, 23 (21), pp.13200 Article dans une revue hal-04584397v1
YB-1 Structure/function relationship in the packaging of mRNPs and consequences for translation regulation and stress granule assembly in cells Loic Hamon,Karina Budkina,David Pastre Biochemistry (mosc.), 2022 Article dans une revue hal-04583907v1
ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs S. Pankivskyi,D. Pastré,E. Steiner,V. Joshi,A. Rynditchet al. Cellular and Molecular Life Sciences, 2021, 78, pp.1745-1763. ⟨10.1007/s00018-020-03610-y⟩ Article dans une revue hal-02968869v1
Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain Anastasiia Samsonova,Krystel El Hage,Bénédicte Desforges,Vandana Joshi,Marie-Jeanne Clémentet al. Communications Biology, 2021, 4 (1), pp.359. ⟨10.1038/s42003-021-01862-3⟩ Article dans une revue hal-03176308v1
The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation Juan Carlos Rengifo-Gonzalez,Krystel El Hage,Marie-Jeanne Clément,Emilie Steiner,Vandana Joshiet al. eLife, 2021, 10, pp.e.67605. ⟨10.7554/eLife.67605⟩ Article dans une revue hal-03343496v1
Identification of a small molecule splicing inhibitor targeting UHM domains Asaki Kobayashi,Marie-Jeanne Clément,Pierrick Craveur,Krystel El Hage,Jean Matha Saloneet al. FEBS Journal, 2021, 289 (3), pp.682-698. ⟨10.1111/febs.16199⟩ Article dans une revue hal-03354012v1
YB-1 unwinds mRNA secondary structures in vitro and negatively regulates stress granule assembly in HeLa cells Karina Budkina,Krystel El Hage,Marie-Jeanne Clément,Bénédicte Desforges,Ahmed Bouhsset al. Nucleic Acids Research, 2021, 49 (17), pp.10061-10081. ⟨10.1093/nar/gkab748⟩ Article dans une revue hal-03333572v1
Inhibition of Transcription Induces Phosphorylation of YB-1 at Ser102 and Its Accumulation in the Nucleus Dmitry Kretov,Daria Mordovkina,Irina Eliseeva,Dmitry Lyabin,Dmitry Polyakovet al. Cells, 2020, 9 (1), pp.104. ⟨10.3390/cells9010104⟩ Article dans une revue hal-02968925v1
Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA Maria Sukhanova,Anastasia Singatulina,David Pastre,Olga Lavrik International Journal of Molecular Sciences, 2020, 21 (19), pp.7020. ⟨10.3390/ijms21197020⟩ Article dans une revue hal-02968942v1
Regulation of Poly(ADP-Ribose) Polymerase 1 Activity by Y-Box-Binding Protein 1 Konstantin Naumenko,Mariya Sukhanova,Loic Hamon,Tatyana Kurgina,Elizaveta Alemasovaet al. Biomolecules, 2020, 10 (9), pp.1325. ⟨10.3390/biom10091325⟩ Article dans une revue hal-02968966v1
A Single-Molecule Atomic Force Microscopy Study of PARP1 and PARP2 Recognition of Base Excision Repair DNA Intermediates Maria Sukhanova,Loic Hamon,Mikhail Kutuzov,Vandana Joshi,Sanae Abrakhiet al. Journal of Molecular Biology, 2019, 431 (15), pp.2655-2673. ⟨10.1016/j.jmb.2019.05.028⟩ Article dans une revue hal-02165889v1
U2AF65 assemblies drive sequence-specific splice site recognition Manel Tari,Valerie Manceau,Jean Matha Salone,Asaki Kobayashi,David Pastreet al. EMBO Reports, 2019, 20 (8), pp.e47604. ⟨10.15252/embr.201847604⟩ Article dans une revue hal-02178664v1
PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA Anastasia Singatulina,Loic Hamon,Maria Sukhanova,Bénédicte Desforges,Vandana Joshiet al. Cell Reports, 2019, 27 (6), pp.1809-1821. ⟨10.1016/j.celrep.2019.04.031⟩ Article dans une revue hal-02167709v1
YB-1, an abundant core mRNA-binding protein, has the capacity to form an RNA nucleoprotein filament: a structural analysis Dmitry Kretov,Marie-Jeanne Clément,Guillaume Lambert,Dominique Durand,Dmitry Lyabinet al. Nucleic Acids Research, 2019, 47 (6), pp.3127-3141. ⟨10.1093/nar/gky1303⟩ Article dans une revue hal-02114790v1
Microtubules as platforms for probing liquid–liquid phase separation in cells – application to RNA-binding proteins Alexandre Maucuer,Bénédicte Desforges,Vandana Joshi,Mirela Boca,Dmitry Kretovet al. Journal of Cell Science, 2018, 131 (11), pp.jcs214692. ⟨10.1242/jcs.214692⟩ Article dans une revue hal-02166855v1
Relation Between Stress Granules and Cytoplasmic Protein Aggregates Linked to Neurodegenerative Diseases Ioana Dobra,Serhii Pankivskyi,Anastasiia Samsonova,David Pastre,Loic Hamon Current Neurology and Neuroscience Reports, 2018, 18 (12), pp.107. ⟨10.1007/s11910-018-0914-7⟩ Article dans une revue hal-02167725v1
Spastin regulates VAMP7-containing vesicles trafficking in cortical neurons C. Plaud,V. Joshi,M. Marinello,D. Pastré,T. Galliet al. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2017, 1863 (6), pp.1666-1677. ⟨10.1016/j.bbadis.2017.04.007⟩ Article dans une revue hal-02173641v1
Vectofusin-1, a potent peptidic enhancer of viral gene transfer forms pH-dependent α-helical nanofibrils, concentrating viral particles Louic Vermeer,Loic Hamon,Alicia Schirer,Michel Schoup,Jérémie Cosetteet al. Acta Biomaterialia, 2017, 64, pp.259-268. ⟨10.1016/j.actbio.2017.10.009⟩ Article dans une revue hal-02174366v1
Nanoscale Analysis Reveals the Maturation of Neurodegeneration-Associated Protein Aggregates Sanae Abrakhi,Dmitry Kretov,Bénédicte Desforges,Ioana Dobra,Ahmed Bouhsset al. ACS Nano, 2017, 11 (7), pp.7189-7200. ⟨10.1021/acsnano.7b03071⟩ Article dans une revue hal-02173623v1
Polyamine signal through gap junctions : A key regulator of proliferation and gap-junction organization in mammalian tissues ? Loic Hamon,Philippe Savarin,David Pastre BioEssays, 2016, 38 (6), pp.498-507. ⟨10.1002/bies.201500195⟩ Article dans une revue istex hal-02174559v1
Single molecule detection of PARP1 and PARP2 interaction with DNA strand breaks and their poly(ADP-ribosyl)ation using high-resolution AFM imaging Maria Sukhanova,Sanae Abrakhi,Vandana Joshi,David Pastre,Mikhail Kutuzovet al. Nucleic Acids Research, 2016, 44 (6), pp.e60-e60. ⟨10.1093/nar/gkv1476⟩ Article dans une revue hal-02183571v1
Role of tau in the spatial organization of axonal microtubules: keeping parallel microtubules evenly distributed despite macromolecular crowding Alix Méphon-Gaspard,Mirela Boca,Catherine Pioche-Durieu,Bénédicte Desforges,Andrea Burgoet al. Cellular and Molecular Life Sciences, 2016, 73 (19), pp.3745-3760. ⟨10.1007/s00018-016-2216-z⟩ Article dans une revue hal-02183396v1
Probing protein interactions in living mammalian cells on a microtubule bench Mirela Boca,Dmitry Kretov,Bénédicte Desforges,Alix Méphon-Gaspard,Patrick A. Curmiet al. Scientific Reports, 2015, 5, pp.17304. ⟨10.1038/srep17304⟩ Article dans une revue hal-02272729v1
mRNA and DNA selection via protein multimerization: YB-1 as a case study Dmitry Kretov,Patrick A. Curmi,Loic Hamon,Sanae Abrakhi,Bénédicte Desforgeset al. Nucleic Acids Research, 2015, 43 (19), pp.9457-9473. ⟨10.1093/nar/gkv822⟩ Article dans une revue hal-02183823v1
Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules Ouissame Bounedjah,Bénédicte Desforges,Ting-Di Wu,Catherine Pioche-Durieu,Sergio Marcoet al. Nucleic Acids Research, 2014, 42 (13), pp.8678-8691. ⟨10.1093/nar/gku582⟩ Article dans une revue hal-02292175v1
An intercellular polyamine transfer via gap junctions regulates proliferation and response to stress in epithelial cells Bénédicte Desforges,Patrick Curmi,Ouissame Bounedjah,Samir Nakib,Loic Hamonet al. Molecular Biology of the Cell, 2013, 24 (10), pp.1505-1613. ⟨10.1091/mbc.E12-10-0729⟩ Article dans une revue hal-02292186v1
Detection of Single DNA Molecule Hybridization on a Surface by Atomic Force Microscopy David Pastre,Vandana Joshi,Patrick Curmi,Loic Hamon Small, 2013, 9 (21), pp.3630-3638. ⟨10.1002/smll.201300546⟩ Article dans une revue istex hal-02291850v1
Macromolecular Crowding Regulates Assembly of mRNA Stress Granules after Osmotic Stress Ouissame Bounedjah,Loic Hamon,Philippe Savarin,Bénédicte Desforges,Patrick Curmiet al. Journal of Biological Chemistry, 2012, 287 (4), pp.2446-2458. ⟨10.1074/jbc.M111.292748⟩ Article dans une revue hal-02292253v1
Phosphorylation Controls the Interaction of the Connexin43 C-Terminal Domain with Tubulin and Microtubules Amal Saidi Brikci-Nigassa,Marie-Jeanne Clément,Tâp Ha-Duong,Elisabeth Adjadj,Latifa Zianiet al. Biochemistry, 2012, 51 (21), pp.4331-4342. ⟨10.1021/bi201806j⟩ Article dans une revue hal-02292202v1
Rapid Assembly and Collective Behavior of Microtubule Bundles in the Presence of Polyamines Loic Hamon,Philippe Savarin,Patrick a. Curmi,David Pastre Biophysical Journal, 2011, 101 (1), pp.205-216. ⟨10.1016/j.bpj.2011.05.022⟩ Article dans une revue hal-02292262v1
Gap junctions favor normal rat kidney epithelial cell adaptation to chronic hypertonicity Bénédicte Desforges,Philippe Savarin,Ouissame Bounedjah,Stephanie Delga,Loic Hamonet al. American Journal of Physiology - Cell Physiology, 2011, 301 (3), pp.C705-C716. ⟨10.1152/ajpcell.00128.2011⟩ Article dans une revue hal-02292290v1
The C Terminus of Tubulin, a Versatile Partner for Cationic Molecules Julien Lefèvre,Konstantin G. Chernov,Vandana Joshi,Stephanie Delga,Flavio Tomaet al. Journal of Biological Chemistry, 2011, 286 (4), pp.3065-3078. ⟨10.1074/jbc.M110.144089⟩ Article dans une revue hal-02292759v1
Charge inversion, condensation and decondensation of DNA and polystyrene sulfonate by polyethylenimine V. Mengarelli,L. Auvray,D. Pastré,M. Zeghal European Physical Journal E: Soft matter and biological physics, 2011, 34, pp.127. ⟨10.1140/epje/i2011-11127-3⟩ Article dans une revue istex hal-02321710v1
A Central Role for Polyamines in Microtubule Assembly in Cells Philippe Savarin,Aurélie Barbet,Stephanie Delga,Vandana Joshi,Loic Hamonet al. Biochemical Journal, 2010, 430 (1), pp.151-159. ⟨10.1042/BJ20091811⟩ Article dans une revue hal-00506521v1
Specific DNA−Protein Interactions on Mica Investigated by Atomic Force Microscopy David Pastré,Loic Hamon,Isabelle Sorel,Eric Le Cam,Patrick Curmiet al. Langmuir, 2010, 26 (4), pp.2618-2623. ⟨10.1021/la902727b⟩ Article dans une revue hal-02293295v1
Mica Surface Promotes the Assembly of Cytoskeletal Proteins Loic Hamon,Dulal Panda,Philippe Savarin,Vandana Joshi,Johann Bernhardet al. Langmuir, 2009, 25 (6), pp.3331-3335. ⟨10.1021/la8035743⟩ Article dans une revue hal-02294800v1
Role of Microtubules in Stress Granule Assembly Konstantin G. Chernov,Aurélie Barbet,Loic Hamon,Lev Ovchinnikov,Patrick Curmiet al. Journal of Biological Chemistry, 2009, 284 (52), pp.36569-36580. ⟨10.1074/jbc.M109.042879⟩ Article dans une revue hal-02295275v1
Polyamine sharing between tubulin dimers favours microtubule nucleation and elongation via facilitated diffusion Alain Mechulam,Konstantin G. Chernov,Elodie Mucher,Loic Hamon,Patrick A. Curmiet al. PLoS Computational Biology, 2009, 5 (1), pp.e1000255. ⟨10.1371/journal.pcbi.1000255⟩ Article dans une revue inserm-00705780v1
Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP proteins YB-1 and PABP Konstantin G. Chernov,Patrick Curmi,Loic Hamon,Alain Mechulam,Lev Ovchinnikovet al. FEBS Letters, 2008, 582 (19), pp.2875-2881. ⟨10.1016/j.febslet.2008.07.019⟩ Article dans une revue hal-02295333v1
YB-1 promotes microtubule assembly in vitro through interaction with tubulin and microtubules Konstantin G. Chernov,Alain Mechulam,Nadezhda Popova,David Pastre,Elena Nadezhdinaet al. BMC Biochemistry, 2008, 9 (1), pp.23. ⟨10.1186/1471-2091-9-23⟩ Article dans une revue hal-02166798v1
High-resolution AFM imaging of single-stranded DNA-binding (SSB) protein--DNA complexes L. Hamon,D. Pastré,P. Dupaigne,C. Breton,E. Camet al. Nucleic Acids Research, 2007, 35 (8), pp.e58-e58. ⟨10.1093/nar/gkm147⟩ Article dans une revue hal-02295472v1
Atomic Force Microscopy Imaging of DNA under Macromolecular Crowding Conditions David Pastre,Loic Hamon,Alain Mechulam,Isabelle Sorel,Sonia Baconnaiset al. Biomacromolecules, 2007, 8 (12), pp.3712-3717. ⟨10.1021/bm700856u⟩ Article dans une revue hal-02295397v1
A new approach to DNA bending by polyamines and its implication in DNA condensation David Pastre,Olivier Piétrement,Fabrice Landousy,Loic Hamon,Isabelle Sorelet al. European Biophysics Journal, 2006, 35 (3), pp.214-223. ⟨10.1007/s00249-005-0025-7⟩ Article dans une revue istex hal-03065301v1
Anionic Polyelectrolyte Adsorption on Mica Mediated by Multivalent Cations: A Solution to DNA Imaging by Atomic Force Microscopy under High Ionic Strengths David Pastre,Loic Hamon,Fabrice Landousy,Isabelle Sorel,Marie-Odile Davidet al. Langmuir, 2006, 22 (15), pp.6651-6660. ⟨10.1021/la053387y⟩ Article dans une revue istex hal-03065293v1
The EcoRI−DNA Complex as a Model for Investigating Protein−DNA Interactions by Atomic Force Microscopy Isabelle Sorel,Olivier Piétrement,Loic Hamon,Sonia Baconnais,Eric Le Camet al. Biochemistry, 2006, 45 (49), pp.14675-14682. ⟨10.1021/bi060293u⟩ Article dans une revue istex hal-03065288v1
Studying the effect of a charged surface on the interaction of bleomycin with DNA using an atomic force microscope Olivier Piétrement,David Pastre,Fabrice Landousy,Marie-Odile David,Stéphane Fusilet al. European Biophysics Journal, 2005, 34 (3), pp.200-207. ⟨10.1007/s00249-004-0443-y⟩ Article dans une revue istex hal-03065310v1
Study of the DNA/ethidium bromide interactions on mica surface by atomic force microscope: Influence of the surface friction David Pastre,Olivier Piétrement,Alain Zozime,Eric Le Cam Biopolymers, 2005, 77 (1), pp.53-62. ⟨10.1002/bip.20185⟩ Article dans une revue istex hal-03065303v1
Reversible Binding of DNA on NiCl 2 -Treated Mica by Varying the Ionic Strength Olivier Piétrement,David Pastre,Stéphane Fusil,Josette Jeusset,Marie-Odile Davidet al. Langmuir, 2003, 19 (7), pp.2536-2539. ⟨10.1021/la026942u⟩ Article dans une revue istex hal-03065317v1
Adsorption of DNA to Mica Mediated by Divalent Counterions: A Theoretical and Experimental Study David Pastre,Olivier Piétrement,Stéphane Fusil,Fabrice Landousy,Josette Jeussetet al. Biophysical Journal, 2003, 85 (4), pp.2507-2518. ⟨10.1016/s0006-3495(03)74673-6⟩ Article dans une revue hal-03065312v1

Communication dans un congrès (1)

Le ciblage des interactions ARN-protéine impliquées dans les maladies humaines : de l'aspect académique à industriel David Pastre ESSI 2023, EVRY SENART SCIENCES ET INNOVATION, Jun 2023, EVRY, France Communication dans un congrès hal-04583447v1

Poster de conférence (1)

Interplay between TDP-43 and FUS in protein assemblies-Influence of mRNA on the aggregation process Clément Demongin,Guillaume Lambert,Vandana Joshi,David Pastre,Loic Hamon Molecular Neurodegeneration and Therapeutic Approaches – Virtual Event, Jan 2021, Online, France. 2021 Poster de conférence hal-03195903v1

Chapitre d'ouvrage (1)

High-Resolution Imaging of Microtubules and Cytoskeleton Structures by Atomic Force Microscopy Loic Hamon,Patrick A. Curmi,David Pastre Methods in Cell Biology, pp.157-174, 2010, ⟨10.1016/S0091-679X(10)95009-7⟩ Chapitre d'ouvrage hal-02294611v1

Brevet (1)

Methods and tools for detecting the impact of compounds on protein, RNA or DNA interactions Guillaume Bollot,Cyril Bauvais,David Pastre,Amandine Molliex,Julien Duezet al. France, Patent n° : EP23171184.7. 2023 Brevet hal-04583151v1

Pré-publication, Document de travail (1)

A complex view of GPCR signal transduction: Molecular dynamics of the histamine H3 membrane receptor L. Herrera-Zúñiga,L. Moreno-Vargas,L. Ballaud,J. Correa-Basurto,D. Prada-Graciaet al. 2020 Pré-publication, Document de travail hal-02968906v1