Delphine Fradin

Publications

Article dans une revue (44)

Unlocking the power of non-coding RNAs: toward real-time cancer monitoring in precision oncology Manon Chang,Thomas Papazyan,Elvire Pons-Tostivint,Delphine Fradin Molecular Cancer, 2026, Online ahead of print. ⟨10.1186/s12943-025-02536-y⟩ Article dans une revue hal-05476236v1
Soluble PD-L1 (sPD-L1) as a biomarker of durable response and survival in patients with advanced non-small cell lung cancer (NSCLC) treated with first-line immune checkpoint inhibitors (ICIs) Adrien Costantini,Paul Takam Kamga,Elvire Pons-Tostivint,Delphine Fradin,Jean-François Emileet al. Cancer Immunology, Immunotherapy, 2025, 74 (9), pp.294. ⟨10.1007/s00262-025-04126-9⟩ Article dans une revue hal-05483439v1
Oncolytic viruses alter the biogenesis of tumor extracellular vesicles and influence their immunogenicity Ugo Hirigoyen,Coraly Guilbaud,Morgane Krejbich,Morgane Fouet,Judith Fresquetet al. Molecular Therapy: Oncology, 2024, 32 (4), pp.200887. ⟨10.1016/j.omton.2024.200887⟩ Article dans une revue inserm-04745858v1
Loss of miR-200c-3p promotes resistance to radiation therapy via the DNA repair pathway in prostate cancer Maureen Labbé,Manon Chang,Benjamin Saintpierre,Franck Letourneur,Laurence de Beaurepaireet al. Cell Death and Disease, 2024, 15 (10), pp.751. ⟨10.1038/s41419-024-07133-3⟩ Article dans une revue inserm-04770147v1
Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment Camille Chatelain,Laurine Berland,Marion Grard,Nicolas Jouand,Judith Fresquetet al. OncoImmunology, 2024, 13 (1), pp.2377830. ⟨10.1080/2162402x.2024.2377830⟩ Article dans une revue inserm-04652311v1
Use of non-small cell lung cancer multicellular tumor spheroids to study the impact of chemotherapy Pauline Hulo,Sophie Deshayes,Judith Fresquet,Anne-Laure Chéné,Stéphanie Blandinet al. Respiratory Research, 2024, 25 (1), pp.156. ⟨10.1186/s12931-024-02791-5⟩ Article dans une revue inserm-04537685v1
DNA methylation dynamics during pregnancy Delphine Fradin,Jorg Tost,Florence Busato,Clémence Mille,Fanny Lachauxet al. Frontiers in Cell and Developmental Biology, 2023, 11, pp.1185311. ⟨10.3389/fcell.2023.1185311⟩ Article dans une revue inserm-04164740v1
TP53 mutations correlate with the non‐coding RNA content of small extracellular vesicles in melanoma Maureen Labbé,Estelle Menoret,Franck Letourneur,Benjamin Saint‐pierre,Laurence de Beaurepaireet al. Journal of Extracellular Biology, 2023, 2, ⟨10.1002/jex2.105⟩ Article dans une revue hal-04198069v1
Therapeutic strategies for non-small cell lung cancer: Experimental models and emerging biomarkers to monitor drug efficacies Clara Bourreau,Lucas Treps,Sébastien Faure,Delphine Fradin,Nicolas Clere Pharmacology & Therapeutics, 2023, pp.108347. ⟨10.1016/j.pharmthera.2023.108347⟩ Article dans une revue hal-03944679v1
Oncolytic attenuated measles virus encoding NY-ESO-1 induces HLA I and II presentation of this tumor antigen by melanoma and dendritic cells Marion Grard,Mohamed Idjellidaine,Atousa Arbabian,Camille Chatelain,Laurine Berlandet al. Cancer Immunology, Immunotherapy, 2023, 72 (10), pp.3309-3322. ⟨10.1007/s00262-023-03486-4⟩ Article dans une revue inserm-04581137v1
The DCMU Herbicide Shapes T-cell Functions By Modulating Micro-RNA Expression Profiles Pierre Autin,Sophie Deshayes,Juliette Lea,Nicolas Boisgerault,Emilie Dupréet al. Frontiers in Immunology, 2022, 13, pp.925241. ⟨10.3389/fimmu.2022.925241⟩ Article dans une revue inserm-03752032v1
Monocyte Signature Associated with Herpes Simplex Virus Reactivation and Neurological Recovery after Brain Injury Tanguy Chaumette,Raphael Cinotti,Alice Mollé,Pierre Solomon,Louise Castainet al. American Journal of Respiratory and Critical Care Medicine, 2022, 206 (3), pp.295-310. ⟨10.1164/rccm.202110-2324OC⟩ Article dans une revue hal-04521801v1
Interaction Between Modern Radiotherapy and Immunotherapy for Metastatic Prostate Cancer Luc Ollivier,Maureen Labbé,Delphine Fradin,Vincent Potiron,Stéphane Supiot Frontiers in Oncology, 2021, 11, pp.744679. ⟨10.3389/fonc.2021.744679⟩ Article dans une revue inserm-03369787v1
Combinaison radiothérapie-immunothérapie en cancérologie génito-urinaire L. Ollivier,V. Guimas,E. Rio,L. Vaugier,I. Massonet al. Cancer/Radiothérapie, 2021, 25 (6-7), pp.565-569. ⟨10.1016/j.canrad.2021.06.033⟩ Article dans une revue inserm-03540455v1
Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers Lyna Kara-Terki,Lucas Treps,Christophe Blanquart,Delphine Fradin International Journal of Molecular Sciences, 2020, 21 (17), pp.6024. ⟨10.3390/ijms21176024⟩ Article dans une revue inserm-02946311v1
Transcriptomic features of tumour- infiltrating CD4 low CD8 high double positive αβ T cells in melanoma Tiphaine Parrot,Romain Oger,Mathilde Allard,Juliette Desfrançois,Diane Raingeard de La Blétìèreet al. Scientific Reports, 2020, 10 (1), pp.5900. ⟨10.1038/s41598-020-62664-x⟩ Article dans une revue inserm-02534481v1
Increased antitumor efficacy of PD-1- deficient melanoma-specific human lymphocytes Lucine Marotte,Sylvain Simon,Virginie Vignard,Emilie Dupré,Malika Gantieret al. Journal for Immunotherapy of Cancer, 2020, 8, pp.e000311. ⟨10.1136/jitc-2019-000311⟩ Article dans une revue inserm-02481085v1
microRNAs identified in prostate cancer: Correlative studies on response to ionizing radiation Maureen Labbé,Christianne Hoey,Jessica Ray,Vincent Potiron,Stephane Supiotet al. Molecular Cancer, 2020, 19, pp.63. ⟨10.1186/s12943-020-01186-6⟩ Article dans une revue inserm-02515300v1
Regulatory T Cell Stability and Migration Are Dependent on mTOR Romain Vallion,Jordane Divoux,Salomé Glauzy,Emilie Ronin,Yannis Lombardiet al. Journal of Immunology, 2020, 205 (7), pp.1799-1809. ⟨10.4049/jimmunol.1901480⟩ Article dans une revue inserm-02946304v1
Frequent Homozygous Deletions of Type I Interferon Genes in Pleural Mesothelioma Confer Sensitivity to Oncolytic Measles Virus Tiphaine Delaunay,Carole Achard,Nicolas Boisgerault,Marion Grard,Tacien Petithommeet al. Journal of Thoracic Oncology, 2020, S1556-0864(20)30019-8, Epub ahead of print. ⟨10.1016/j.jtho.2019.12.128⟩ Article dans une revue inserm-02447160v1
MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma Virginie Vignard,Maureen Labbé,Nadège Marec,Gwennan André-Grégoire,Nicolas Jouandet al. Cancer Immunology Research, 2019, canimm.0522.2019, Epub ahead of print. ⟨10.1158/2326-6066.CIR-19-0522⟩ Article dans une revue inserm-02426329v1
Viral and tumor antigen-specific CD8 T-cell responses in Merkel cell carcinoma Mahtab Samimi,Houssem Benlalam,Pascal Aumond,Pauline Gaboriaud,Delphine Fradinet al. Cellular Immunology, 2019, 344, 8 p. ⟨10.1016/j.cellimm.2019.103961⟩ Article dans une revue inserm-02284748v1
Epigenetic Drugs for Cancer and microRNAs: A Focus on Histone Deacetylase Inhibitors Pierre Autin,Christophe Blanquart,Delphine Fradin Cancers, 2019, 11 (10), pp.1530. ⟨10.3390/cancers11101530⟩ Article dans une revue inserm-02315396v1
Fetal growth is associated with the CpG methylation of the P2 promoter of the IGF1 gene Catherine Le Stunff,Anne-Laure Castell,Nicolas Todd,Clémence Mille,Marie-Pierre Belotet al. Clinical Epigenetics, 2018, 10, pp.57. ⟨10.1186/s13148-018-0489-9⟩ Article dans une revue inserm-01782203v1
Non-Coding RNAs in Cutaneous Melanoma Development, Progression and Dissemination Virginie Vignard,Delphine Fradin OBM Genetics, 2018, 2 (2), pp.1 - 1. ⟨10.21926/obm.genet.1802020⟩ Article dans une revue inserm-01804848v1
Correction to: Fetal growth is associated with CpG methylation in the P2 promoter of the IGF1 gene Catherine Le Stunff,Anne-Laure Castell,Nicolas Todd,Clémence Mille,Marie-Pierre Belotet al. Clinical Epigenetics, 2018, 10 (1), pp.74. ⟨10.1186/s13148-018-0506-z⟩ Article dans une revue hal-04961045v1
Genome-Wide Methylation Analysis Identifies Specific Epigenetic Marks In Severely Obese Children Delphine Fradin,Pierre-Yves Boëlle,Marie-Pierre Belot,Fanny Lachaux,Jorg Tostet al. Scientific Reports, 2017, 7, pp.46311. ⟨10.1038/srep46311⟩ Article dans une revue hal-01516806v1
Role of DNA methylation at the placental RTL1 gene locus in type 1 diabetes Marie-Pierre Belot,Kambiz Nadéri,Clémence Mille,Pierre-Yves Boëlle,Alexandra Benachiet al. Pediatric Diabetes, 2017, 18 (3), pp.178-187. ⟨10.1111/pedi.12387⟩ Article dans une revue inserm-02320514v1
The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature Danny Ben-Avraham,Diddahally Govindaraju,Temuri Budagov,Delphine Fradin,Peter Durdaet al. Science Advances , 2017, 3 (6), pp.e1602025. ⟨10.1126/sciadv.1602025⟩ Article dans une revue inserm-02320509v1
The P2 promoter of the IGF1 gene is a major epigenetic locus for GH responsiveness M Ouni,M P Belot,A. L. Castell,Delphine Fradin,P Bougnères Pharmacogenomics Journal, 2016, 16, pp.102-106. ⟨10.1038/tpj.2015.26⟩ Article dans une revue hal-02329906v1
A lineage-specific methylation pattern controls the transcription of the polycistronic mRNA coding MELOE melanoma antigens Benjamin Chalopin,Laetitia Florenceau,Delphine Fradin,Nathalie Labarrière,Agnès Moreau-Aubry Melanoma Research, 2015, ⟨10.1097/CMR.0000000000000167⟩ Article dans une revue inserm-01280880v1
The IGF1 P2 promoter is an epigenetic QTL for circulating IGF1 and human growth Meriem Ouni,Marie Pierre Belot,Anne-Laure Castell,Delphine Fradin,Pierre Bougneres Clinical Epigenetics, 2015, 7, pp.22. ⟨10.1186/s13148-015-0062-8⟩ Article dans une revue hal-02459502v1
Hypomethylation of the promoter of the catalytic subunit of protein phosphatase 2A in response to hyperglycemia Fabiola Tros,Aline Meirhaeghe,Samy Hadjadj,Philippe Amouyel,Pierre Bougnèreset al. Physiological Reports, 2014, 2, ⟨10.14814/phy2.12076⟩ Article dans une revue inserm-02459029v1
β cells keep bad epigenetic memories of palmitate Delphine Fradin,Pierre Bougnères BMC Medicine, 2014, 12 (1), ⟨10.1186/1741-7015-12-104⟩ Article dans une revue hal-02329943v1
CpG Methylation Changes within the IL2RA Promoter in Type 1 Diabetes of Childhood Onset Marie-Pierre Belot,Delphine Fradin,Nga Mai,Sophie Le Fur,Diana Zelenikaet al. PLoS ONE, 2013, 8 (7), pp.e68093. ⟨10.1371/journal.pone.0068093⟩ Article dans une revue hal-02329956v1
Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes Delphine Fradin,Sophie Le Fur,Clémence Mille,Nadia Naoui,Chris Groveset al. PLoS ONE, 2012, 7 (5), pp.e36278. ⟨10.1371/journal.pone.0036278⟩ Article dans une revue hal-02329970v1
XPG and XPF Endonucleases Trigger Chromatin Looping and DNA Demethylation for Accurate Expression of Activated Genes Nicolas Le may,Delphine Fradin,Izarn Iltis,Pierre Bougneres,Jean Marc Egly Molecular Cell, 2012, 47 (4), pp.622-632. ⟨10.1016/j.molcel.2012.05.050⟩ Article dans une revue hal-02329959v1
T2DM: Why Epigenetics? Delphine Fradin,Pierre Bougneres Journal of Nutrition and Metabolism, 2011, 2011, pp.1-17. ⟨10.1155/2011/647514⟩ Article dans une revue hal-02329973v1
Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index Delphine Fradin,Rafael A Irizarry,Martin J Aryee,Peter Murakami,Thor Aspelundet al. Science Translational Medicine, 2010, 2 (49), pp.49ra67-49ra67. ⟨10.1126/scitranslmed.3001262⟩ Article dans une revue hal-02329984v1
Parent-Of-Origin Effects in Autism Identified through Genome-Wide Linkage Analysis of 16,000 SNPs Delphine Fradin,Keely Cheslack-Postava,Christine Ladd-Acosta,Craig Newschaffer,Aravinda Chakravartiet al. PLoS ONE, 2010, 5 (9), pp.e12513. ⟨10.1371/journal.pone.0012513⟩ Article dans une revue hal-02329988v1
Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study Delphine Fradin,M Daniele Fallin BMC Proceedings, 2009, 3 (S7), ⟨10.1186/1753-6561-3-S7-S113⟩ Article dans une revue hal-02329993v1
Three Common Variants of LEP, NPY1R and GPR54 Show No Association with Age at Menarche Anya Rothenbuhler,Chantal Lotton,Delphine Fradin Hormone Research in Paediatrics, 2009, 71 (6), pp.331-335. ⟨10.1159/000223417⟩ Article dans une revue hal-02329997v1
Three Common Intronic Variants in the Maternal and Fetal Thiamine Pyrophosphokinase Gene (TPK1) are Associated with Birth Weight Delphine Fradin,Pierre Bougneres Annals of Human Genetics, 2007, ⟨10.1111/j.1469-1809.2007.00348.x⟩ Article dans une revue hal-02459482v1
Non-Mendelian' genetics of fetal growth Delphine Fradin,Pascal Boileau,Jacques Lepercq,Pierre Bougneres Journal of Endocrinological Investigation, 2006, 29 (Supp 1), pp.11-15 Article dans une revue hal-02459429v1

Communication dans un congrès (10)

ExomiR : Etude des microARNs des exosomes tumoraux Delphine Fradin 13ème journées du Cancéropole Grand Ouest, Jul 2019, Tours, France Communication dans un congrès hal-02459683v1
INTERNALISATION DES EXOSOMES DE MELANOME PAR LES LYMPHOCYTES T CD8+ ET IMPACT SUR LEURS FONCTIONS : APPORT DU CYTOMETRE IMAGEUR Delphine Fradin,Nicolas Jouand Journée Imagerie fonctionnelle pré-clinique, Jun 2019, Rennes, France Communication dans un congrès hal-02459677v1
L'EPIGENETIQUE, C'EST QUOI ? Delphine Fradin 22ème journées de Médecine Foetale, Mar 2017, Nice, France Communication dans un congrès hal-02459664v1
EXPLORATION DES FONCTIONS IMMUNOSUPPRESSIVES DES ARN NON CODANTS CONTENUS DANS LES EXOSOMES DU MÉLANOME Delphine Fradin 3ème journées RepiCGO, Dec 2016, Brest, France Communication dans un congrès hal-02459657v1
Influence de l'hyperglycémie sur la méthylation de l'ADN Delphine Fradin Automnales du GRRC, Nov 2015, Pornichet, France Communication dans un congrès hal-02459651v1
EVOLUTION DES MARQUES ÉPIGÉNÉTIQUES AU COURS DE LA VIE Delphine Fradin ADELF-EPITER, Sep 2014, Nice, France Communication dans un congrès hal-02459594v1
GÉNÉTIQUE ET ÉPIGÉNÉTIQUE DU COMPORTEMENT SOCIAL Delphine Fradin Journées de l'Ecole Doctorale Pierre Louis de Santé Publique, Oct 2012, Saint Malo, France Communication dans un congrès hal-02459610v1
EPIGÉNÉTIQUE ET HYPERGLYCÉMIE : RÔLE DE LA MÉTHYLATION DANS LA RÉTINOPATHIE DIABÉTIQUE Delphine Fradin 4e congrès annuel du CORDDIM, Sep 2012, Paris, France Communication dans un congrès hal-02459620v1
Aging and DNA methylation Delphine Fradin Seventh Annual Grantee Meeting of Centers of Excellence in Genomic Science, Oct 2009, Huntsville, United States Communication dans un congrès hal-02459631v1
INFLUENCE OF CONTROL SELECTION IN GENOME-WIDE ASSOCIATION STUDY: THE EXAMPLE OF DIABETES IN THE FRAMIGHAM HEART STUDY. Delphine Fradin Genetic Analysis Workshop 16, Sep 2008, Saint Louis, United States Communication dans un congrès hal-02459645v1

Poster de conférence (2)

ROLE OF miRNA FROM MELANOMA CELL-DERIVED EXOSOMES IN TUMOR IMMUNE ESCAPE Virginie Vignard,Nathalie Labarrière,Delphine Fradin Extracellular Vesicles in Therapeutics & Healthy Diet, Jun 2017, Nantes, France Poster de conférence hal-02459718v1
Allele Dependent DNA Methylation of the Human Insulin Gene Promoter in T2D patients and Controls Delphine Fradin,Clémence Mille,Nadia Naoui,Chris Groves,Mark Mccarthyet al. Epigenomics of Common Diseases, Oct 2012, Baltimore, United States Poster de conférence hal-02459574v1