stephane Depil

Publications

Article dans une revue (31)

Type III interferon primes pDCs for TLR7 activation and antagonizes immune suppression mediated by TGF-β and PGE2 Candice Sakref,Alexis Saby,Céline Rodriguez,Maude Ardin,Lyvia Moudombiet al. Nature Communications, 2025, 16 (1), pp.3045. ⟨10.1038/s41467-025-58220-8⟩ Article dans une revue hal-05021654v1
HERV-derived epitopes represent new targets for T-cell-based immunotherapies in ovarian cancer Paola Bonaventura,Audrey Page,Olivier Tabone,Yann Estornes,Virginie Mutezet al. Journal for Immunotherapy of Cancer, 2025, 13 (8), pp.e010099. ⟨10.1136/jitc-2024-010099⟩ Article dans une revue hal-05288554v1
Targeting heterochromatin eliminates chronic myelomonocytic leukemia malignant stem cells through reactivation of retroelements and immune pathways Donia Hidaoui,Audrey Porquet,Rabie Chelbi,Mathieu Bohm,Aikaterini Polyzouet al. Communications Biology, 2024, 7 (1), pp.1555. ⟨10.1038/s42003-024-07214-1⟩ Article dans une revue hal-04916245v1
Development of NK cell-based cancer immunotherapies through receptor engineering Audrey Page,Nicolas Chuvin,Jenny Valladeau-Guilemond,Stéphane Depil Cellular and molecular immunology, 2024, 21, pp.315 - 331. ⟨10.1038/s41423-024-01145-x⟩ Article dans une revue (article de synthèse) hal-04567993v1
Endogenous retroelements in hematological malignancies: From epigenetic dysregulation to therapeutic targeting Mohamed Chour,Françoise Porteu,Stéphane Depil,Vincent Alcazer American Journal of Hematology, 2024, 100 (1), pp.116-130. ⟨10.1002/ajh.27501⟩ Article dans une revue inserm-04902678v1
Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7 &lt;sup&gt;th&lt;/sup&gt; immunorad conference Pierre-Antoine Laurent,Fabrice André,Alexandre Bobard,Desiree Deandreis,Sandra Demariaet al. OncoImmunology, 2024, 14, ⟨10.1080/2162402x.2024.2432726⟩ Article dans une revue hal-04940881v1
Targeting Heterochromatin Eliminates Malignant Hematopoietic Stem and Progenitor Cells in Chronic Myelomonocytic Leukemia Through Reactivation of Retroelements and Innate Immune pathways Donia Hidaoui,Rabie Chelbie,Mathieu Bohm,Audrey Porquet,Aikaterini Polyzouet al. Communications Biology, 2024, 7, pp.1555. ⟨10.1038/s42003-024-07214-1⟩ Article dans une revue hal-04471048v1
TCR-engineered T cell therapy in solid tumors: State of the art and perspectives Estelle Baulu,Célia Gardet,Nicolas Chuvin,Stéphane Depil Science Advances , 2023, 9 (7), ⟨10.1126/sciadv.adf3700⟩ Article dans une revue hal-04115921v1
Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor Benjamin Ducarouge,Anna-Rita Redavid,Camille Victoor,Ruxanda Chira,Aurélien Fonsecaet al. Cell Death and Differentiation, 2023, 30 (10), pp.2201-2212. ⟨10.1038/s41418-023-01209-x⟩ Article dans une revue hal-04253805v1
Tumour burden and antigen-specific T cell magnitude represent major parameters for clinical response to cancer vaccine and TCR-engineered T cell therapy Marion Mallet,Rasha Boulos,Vincent Alcazer,Paola Bonaventura,Yann Estorneset al. European Journal of Cancer, 2022, 171, pp.96-105. ⟨10.1016/j.ejca.2022.05.008⟩ Article dans une revue hal-03784075v1
Radiotherapy as a means to increase the efficacy of T-cell therapy in solid tumors Pierre-Antoine Laurent,Daphne Morel,Lydia Meziani,Stéphane Depil,Eric Deutsch OncoImmunology, 2022, 12 (1), pp.2158013. ⟨10.1080/2162402x.2022.2158013⟩ Article dans une revue (article de synthèse) hal-04482410v1
Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy Paola Bonaventura,Vincent Alcazer,Virginie Mutez,Laurie Tonon,Juliette Martinet al. Science Advances , 2022, 8 (4), ⟨10.1126/sciadv.abj3671⟩ Article dans une revue hal-03552937v1
HERVs characterize normal and leukemia stem cells and represent a source of shared epitopes for cancer immunotherapy Vincent Alcazer,Paola Bonaventura,Laurie Tonon,Emilie Michel,Virginie Mutezet al. American Journal of Hematology, 2022, 97 (9), pp.1200-1214. ⟨10.1002/ajh.26647⟩ Article dans une revue hal-03855460v1
Développement des CAR-T allogéniques Vincent Alcazer,Stéphane Depil Bulletin du Cancer, 2021, 108 (10), pp.S73-S80. ⟨10.1016/j.bulcan.2021.01.025⟩ Article dans une revue hal-03784063v1
Approches d’immunothérapie cellulaire T dans les tumeurs solides Estelle Baulu,Aurore Dougé,Nicolas Chuvin,Jacques-Olivier Bay,Stéphane Depil Bulletin du Cancer, 2021, 108 (10), pp.S96-S108. ⟨10.1016/j.bulcan.2021.06.004⟩ Article dans une revue hal-03784069v1
Les lymphocytes T CD4 + jouent un rôle majeur dans la réponse immunitaire antitumorale Lucie Leclair,Stéphane Depil Médecine/Sciences, 2021, 37 (6-7), pp.671-673. ⟨10.1051/medsci/2021075⟩ Article dans une revue hal-03784058v1
‘Off-the-shelf’ allogeneic CAR T cells: development and challenges S. Depil,P. Duchateau,S. Grupp,G. Mufti,L. Poirot Nature Reviews Drug Discovery, 2020, 19 (3), pp.185-199. ⟨10.1038/s41573-019-0051-2⟩ Article dans une revue hal-03784053v1
Human Endogenous Retroviruses (HERVs): Shaping the Innate Immune Response in Cancers Vincent Alcazer,Paola Bonaventura,Stéphane Depil Cancers, 2020, 12 (3), pp.610. ⟨10.3390/cancers12030610⟩ Article dans une revue (article de synthèse) hal-03784048v1
Granulocyte–macrophage colony-stimulating factor inactivation in CAR T-cells prevents monocyte-dependent release of key cytokine release syndrome mediators Mohit Sachdeva,Philippe Duchateau,Stéphane Depil,Laurent Poirot,Julien Valton Journal of Biological Chemistry, 2019, 294 (14), pp.5430-5437. ⟨10.1074/jbc.AC119.007558⟩ Article dans une revue hal-03784028v1
Cancer vaccines: what’s next? Stéphane Depil,Paola Bonaventura,Vincent Alcazer Oncotarget, 2019, 10 (40), pp.3985-3987. ⟨10.18632/oncotarget.27006⟩ Article dans une revue hal-03784033v1
Modulation of chimeric antigen receptor surface expression by a small molecule switch Alexandre Juillerat,Diane Tkach,Brian Busser,Sonal Temburni,Julien Valtonet al. BMC Biotechnology, 2019, 19 (1), pp.44. ⟨10.1186/s12896-019-0537-3⟩ Article dans une revue hal-03784035v1
Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade Tala Shekarian,Eva Sivado,Anne-Catherine Jallas,Stéphane Depil,Janice Kielbassaet al. Science Translational Medicine, 2019, 11 (515), pp.eaat5025. ⟨10.1126/scitranslmed.aat5025⟩ Article dans une revue hal-02347852v1
Cancer-Associated Fibroblasts Produce Netrin-1 to Control Cancer Cell Plasticity Pei-Ju Sung,Nicolas Rama,Jeromine Imbach,Stephany Fiore,Benjamin Ducarougeet al. Cancer Research, 2019, 79 (14), pp.3651-3661. ⟨10.1158/0008-5472.CAN-18-2952⟩ Article dans une revue hal-02323505v1
Cold Tumors: A Therapeutic Challenge for Immunotherapy Paola Bonaventura,Tala Shekarian,Vincent Alcazer,Jenny Valladeau-Guilemond,Sandrine Valsesia-Wittmannet al. Frontiers in Immunology, 2019, 10, pp.168. ⟨10.3389/fimmu.2019.00168⟩ Article dans une revue (article de synthèse) hal-03769056v1
Pattern recognition receptors: immune targets to enhance cancer immunotherapy Tala Shekarian,Sandrine Valsesia-Wittmann,J. Brody,Marie-Cécile Michallet,Stéphane Depilet al. Annals of Oncology, 2019, 30 (12), pp.2017. ⟨10.1093/annonc/mdz225⟩ Article dans une revue hal-03784051v1
Neoepitopes-based vaccines: challenges and perspectives Vincent Alcazer,Paola Bonaventura,Laurie Tonon,Sandrine Wittmann,Christophe Cauxet al. European Journal of Cancer, 2019, 108, pp.55 - 60. ⟨10.1016/j.ejca.2018.12.011⟩ Article dans une revue hal-03486167v1
Développement des CAR-T dans les tumeurs solides Vincent Alcazer,Christophe Delenda,Laurent Poirot,Stéphane Depil Bulletin du Cancer, 2018, 105, pp.S178 - S187. ⟨10.1016/S0007-4551(19)30048-7⟩ Article dans une revue hal-03486670v1
Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers M. Grandin,M. Meier,J.G. Delcros,D. Nikodemus,R. Reutenet al. Cancer Cell, 2016, 29, pp.173-185. ⟨10.1016/j.ccell.2016.01.001⟩ Article dans une revue hal-01792608v1
HDAC inhibition does not induce estrogen receptor in human triple-negative breast cancer cell lines and patient-derived xenografts Patricia De Cremoux,Mathieu Dalvai,Olivia N'Doye,Fatima Moutahir,Gaëlle Rollandet al. Breast Cancer Research and Treatment, 2015, 149 (1), pp.81-89. ⟨10.1007/s10549-014-3233-y⟩ Article dans une revue hal-03653860v1
Decoding and unlocking the BCL‐2 dependency of cancer cells Philippe Juin,Olivier Geneste,Fabien Gautier,Stéphane Depil,Mario Campone Nature Reviews Cancer, 2013, 13 (7), pp.455-465. ⟨10.1038/nrc3538⟩ Article dans une revue inserm-02481124v1
EBV Latency II-derived Peptides Induce A Specific CD4+ Cytotoxic T-cell Activity and Not A CD4+ Regulatory T-cell Response Olivier Moralès,Stéphane Depil,Dhafer Mrizak,Nathalie Martin,Papa Alioune Ndouret al. Journal of Immunotherapy, 2012, 35 (3), pp.254-266. ⟨10.1097/CJI.0b013e31824d72c5⟩ Article dans une revue hal-03059998v1

Pré-publication, Document de travail (1)

Targeting a shared neoepitope derived from non-canonical translation of c- MYC oncogene in cancer cells E. Baulu,A. Bolon,E. Etchegaray,F. Raimundo,A. Merienneet al. 2025 Pré-publication, Document de travail hal-05005174v1

Brevet (2)

New method for identifying herv-derived epitopes Stéphane Depil,Vincent Alcazer France, Patent n° : WO2023144231A1. 2023 Brevet hal-04940990v1
Antigènes dérivés d'herv-k en tant qu'antigènes tumoraux partagés pour un vaccin anticancéreux Stéphane Depil,Laurie Tonon,Christophe Caux,Paola Bonaventura,Jenny Valladeau-Guilemond France, Patent n° : WO2020049169A1. 2020 Brevet hal-04940961v1

Chapitre d'ouvrage (1)

Off-the-Shelf Allogeneic CAR-T Cells or Other Immune Effector Cells Stéphane Depil,Waseem Qasim The EBMT/EHA CAR-T Cell Handbook, Springer International Publishing, pp.51-54, 2022, ⟨10.1007/978-3-030-94353-0_9⟩ Chapitre d'ouvrage hal-03784072v1

Poster de conférence (1)

Integrative approaches for the identification of therapeutic targets in basal-like breast cancer from multi-level molecular data B. M. Tesson,Guillem Rigaill,D. Gentien,S. Roman-Roman,F. Cruzaleguiet al. 22. Biennial Congress of the European Association for Cancer Research, Jul 2012, Barcelone, Spain. Elsevier Science LTD, European Journal of Cancer, 48 (Suppl. 5), 2012, European Journal of Cancer Poster de conférence hal-01189748v1