Dimitri Fayolle

Identifiants chercheurs

IdHAL :

dimitri-fayolle

ORCID :

0000-0002-1543-136X

Présentation

Dr Dimitri Fayolle is a physical chemist applying analytical tools to drug discovery, mostly through the determination of druggability parameters. He is a Research Engineer and the principal scientist of the Drug Innovation and Design platform (DruiD) at the CERMN laboratory (University of Caen, FR).

After a BSc in physical chemistry (2015, Montpellier, FR) and a MSc in organic synthesis (2017, Lyon, FR), he defended in 2020 a PhD thesis in bioorganic chemistry under the supervision of Prof. Peter Strazewski in Lyon, FR, studying the formation of complex mixtures of small amphiphilic biomolecules under conditions mimicking the origins of life, and the anchoring of such molecules to cell-like membranes. A large part of this research revolved around LC/MS and liquid-state NMR.

He was then recruited in early 2022 as a postdoctoral researcher in magnetic resonance at the University of Caen, developing new technologies for 129Xe magnetic resonance imaging in preclinical research, before becoming a permanent Research Engineer at the CERMN laboratory of the University of Caen in 2023. He is now in charge of the newly-founded Drug Innovation and Design platform of the lab. The platform offers its expertise in medicinal chemistry, biological activity screeining (enzymology, receptor binding...), drugability profiling (solubility, lipophilicity, permeation) and galenics, and is open to collaboration with academics and pharmaceutical companies. Dr Fayolle's research currently focuses on the determination of the lipophilicity of drugs, including emergent classes such as macromolecules.

Publications

Article dans une revue (12)

ID Card of Mcl-1 PROTAC degrader: From in silico design to biological validation in chemoresistant ovarian cancer Marie Cornu,Jocelyn Pezeril,Nicolas Guedeney,Hippolyte Paysant,Thomas Lemaitreet al. European Journal of Medicinal Chemistry Reports, 2026, 17, pp.100336. ⟨10.1016/j.ejmcr.2026.100336⟩ Article dans une revue hal-05583537v1
The NagY antiterminator in Enterococcus faecalis: a novel regulatory mechanism and its impact on cell metabolism Diane Soussan,Marine Salze,Blandine Harel,Victor Combret,Erwan Bourdonnaiset al. Microbiology Spectrum, 2025, 13 (10), ⟨10.1128/spectrum.01137-25⟩ Article dans une revue hal-05322484v1
Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential Omar Khoumeri,Sébastien Hutter,Nicolas Primas,Caroline Castera-Ducros,Sandra Carvalhoet al. Pharmaceuticals, 2024, 17 (7), pp.878. ⟨10.3390/ph17070878⟩ Article dans une revue hal-04635068v1
A biomimetic multiparametric assay to characterise anti-amyloid drugs Willy Smeralda,Marc Since,Sophie Corvaisier,Dimitri Fayoll,Julien Cardinet al. International Journal of Molecular Sciences, 2023, 24 (23), pp.16982. ⟨10.3390/ijms242316982⟩ Article dans une revue hal-04315267v1
Synthesis of phospholipids under plausible prebiotic conditions and analogies with phospholipid biochemistry or origin of life studies Michele Fiore,Carolina Chieffo,Augustin Lopez,Dimitri Fayolle,Johal Ruizet al. Astrobiology, In press, ⟨10.1089/ast.2021.0059⟩ Article dans une revue hal-03591985v1
Synthesis and Physicochemical Properties of Cryptophazane—A Soluble and Functionalizable C 1 ‐Symmetrical Cryptophane Clément Vigier,Dimitri Fayolle,Hussein El Siblani,Jana Sopkova - de Oliveira Santos,Frederic Fabiset al. Angewandte Chemie, 2022, 134 (46), ⟨10.1002/ange.202208580⟩ Article dans une revue hal-03854418v1
Racemic Phospholipids for Origin of Life Studies Emiliano Altamura,Arnaud Comte,Alice D’onofrio,Charlotte Roussillon,Dimitri Fayolleet al. Symmetry, 2020, 12 (7), pp.1108. ⟨10.3390/sym12071108⟩ Article dans une revue hal-04939086v1
Chemical Analysis of Lipid Boundaries after Consecutive Growth and Division of Supported Giant Vesicles Augustin Lopez,Dimitri Fayolle,Michele Fiore,Peter Strazewski iScience, 2020, 23, pp.101677 -. ⟨10.1016/j.isci.2020.101677⟩ Article dans une revue hal-03493161v1
Towards the preparation of synthetic outer membrane vesicle models with micromolar affinity to wheat germ agglutinin using a dialkyl thioglycoside Dimitri Fayolle,Nathalie Berthet,Bastien Doumèche,Olivier Renaudet,Peter Strazewskiet al. Beilstein Journal of Organic Chemistry, 2019, 15, pp.937-946. ⟨10.3762/bjoc.15.90⟩ Article dans une revue hal-02120795v1
Towards the preparation of synthetic outer membrane vesicle models with micromolar affinity to wheat germ agglutinin using a dialkyl thioglycoside Dimitri Fayolle,Nathalie Berthet,Bastien Doumeche,Olivier Renaudet,Peter Strazewskiet al. Beilstein Journal of Organic Chemistry, 2019, 15, pp.937-946. ⟨10.3762/bjoc.15.90⟩ Article dans une revue hal-04975190v1
Rapid purification of giant lipid vesicles by microfiltration Dimitri Fayolle,Michele Fiore,Pasquale Stano,Peter Strazewski,Peter Butko PLoS ONE, 2018, 13 (2), pp.e0192975. ⟨10.1371/journal.pone.0192975⟩ Article dans une revue hal-02121315v1
Crude phosphorylation mixtures containing racemic lipid amphiphiles self-assemble to give stable primitive compartments Dimitri Fayolle,Emiliano Altamura,Alice d'Onofrio,Warren Madanamothoo,Bernard Fenetet al. Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-18053-y⟩ Article dans une revue hal-02122490v1