Edith Le Floch Ingénieur-Chercheur CEA, responsable de l'équipe Mathématiques et Statistiques du CNRGH

Publications

Pré-publication, Document de travail (1)

Preliminary evaluation of the Transfer Learning capabilities of MOTL for multi-omics cancer survival analysis Arnaud Gloaguen,Vincent Le Goff,Edith Le Floch 2026 Pré-publication, Document de travail (working paper) cea-05554714v1

Article dans une revue (20)

Characterization of challenging forensic DNA traces using advanced molecular technologies Amel Larnane,Caroline Lefèvre-Horgues,Corinne Cruaud,Cédric Fund,Edith Le Flochet al. International Journal of Legal Medicine, 2025, 139 (4), pp.1511-1527. ⟨10.1007/s00414-025-03448-8⟩ Article dans une revue hal-05159911v1
GNNenrich: a novel method for pathway enrichment analysis based on graph neural network Mallek Mziou-Sallami,Pierrick Roger,Arnaud Gloaguen,Claire Dandine-Roulland,Thierry Jiogho Ngahoet al. Bioinformatics, 2025, 41 (9), pp.btaf478. ⟨10.1093/bioinformatics/btaf478⟩ Article dans une revue hal-05492025v1
Human genetic structure in Northwest France provides new insights into West European historical demography Isabel Alves,Joanna Giemza,Michael Blum,Carolina Bernhardsson,Stéphanie Chatelet al. Nature Communications, 2024, 15 (1), pp.6710. ⟨10.1038/s41467-024-51087-1⟩ Article dans une revue hal-04683810v2
Comprehensive catalog of variants potentially associated with hidradenitis suppurativa, including newly identified variants from a cohort of 100 patients Kévin Muret,Vincent Le Goff,Claire Dandine-Roulland,Claire Hotz,Francette Jean-Louiset al. International Journal of Molecular Sciences, 2024, 25 (19), pp.10374. ⟨10.3390/ijms251910374⟩ Article dans une revue cea-04719777v1
Layer myocardial strain is the most heritable echocardiographic trait Olivier Huttin,Constance Xhaard,Claire Dandine-Roulland,Edith Le Floch,Delphine Bacq-Daianet al. European Heart Journal - Cardiovascular Imaging, 2023, 24 (10), pp.1394-1403. ⟨10.1093/ehjci/jead146⟩ Article dans une revue hal-04192912v1
Shared Heritability of Blood Pressure and Pulse Wave Velocity Constance Xhaard,Pierre de Villemereuil,Athanase Benetos,Erwan Bozec,Claire Dandine-Roullandet al. Hypertension, 2023, 80 (7), pp.1526-1533. ⟨10.1161/HYPERTENSIONAHA.122.20740⟩ Article dans une revue hal-04193168v1
Weak association between genetic markers of hyperuricemia and cardiorenal outcomes: insights from the STANISLAS study cohort with a 20‐year follow‐up Mehmet Kanbay,Constance Xhaard,Edith Le Floch,Claire Dandine-Roulland,Nicolas Girerdet al. Journal of the American Heart Association, 2022, 11, pp.e023301. ⟨10.1161/JAHA.121.023301⟩ Article dans une revue hal-03652891v1
Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness Magnus Bäck,Constance Xhaard,Raphael Rouget,Quentin Thuillier,Oscar Plundeet al. European Heart Journal Open, 2022, pp.oeac016. ⟨10.1093/ehjopen/oeac016⟩ Article dans une revue hal-03613927v1
Identification of risk loci for primary aldosteronism in genome-wide association studies Edith Le Floch,Teresa Cosentino,Casper K Larsen,Felix Beuschlein,Martin Reinckeet al. Nature Communications, 2022, 13 (1), pp.5198. ⟨10.1038/s41467-022-32896-8⟩ Article dans une revue inserm-03845164v1
Genome-wide haplotype association study in imaging genetics using whole-brain sulcal openings of 16,304 UK Biobank subjects Slim Karkar,Claire Dandine-Roulland,Jean-François Mangin,Yann Le Guen,Cathy Philippeet al. European Journal of Human Genetics, 2021, 29 (9), pp.1424-1437. ⟨10.1038/s41431-021-00827-8⟩ Article dans une revue cea-04359983v1
PIntMF: Penalized Integrative Matrix Factorization method for multi-omics data Morgane Pierre-Jean,Florence Mauger,Jean-François Deleuze,Edith Le Floch Bioinformatics, 2021, 38 (4), pp.900-907. ⟨10.1093/bioinformatics/btab786⟩ Article dans une revue hal-03154671v1
Impact of natriuretic peptide polymorphisms on diastolic and metabolic function in a populational cohort: insights from the STANISLAS cohort Constance Xhaard,Raphaël Rouget,Nicolas Vodovar,Edith Le Floch,Claire Dandine‐roullandet al. ESC Heart Failure, 2021, ⟨10.1002/ehf2.13674⟩ Article dans une revue hal-03414759v1
Genetics of severe hypercholesterolemia in the general population Constance Xhaard,João Pedro Ferreira,Edith Le Floch,Zohra Lamiral,Claire Dandine-Roullandet al. Journal of Atherosclerosis Prevention and Treatment, 2021, 12 (3), pp.73-83. ⟨10.53590/japt.02.1026⟩ Article dans une revue hal-03579126v1
Region-specific expression of young small-scale duplications in the human central nervous system Solène Brohard-Julien,Vincent Frouin,Vincent Meyer,Smahane Chalabi,Jean-François Deleuzeet al. BMC Ecology and Evolution, 2021, 21, pp.59. ⟨10.1186/s12862-021-01794-w⟩ Article dans une revue hal-03353892v1
Circulating plasma proteins and new-onset diabetes in a population-based study: proteomic and genomic insights from the STANISLAS cohort Joao Pedro Ferreira,Zohra Lamiral,Constance Xhaard,Kévin Duarte,Emmanuel Bressoet al. European Journal of Endocrinology, 2020, 183 (3), pp.285-295. ⟨10.1530/EJE-20-0246⟩ Article dans une revue hal-02917113v1
Exploring the link between additive heritability and prediction accuracy from a ridge regression perspective Arthur Frouin,Claire Dandine-Roulland,Morgane Pierre-Jean,Jean-François Deleuze,Christophe Ambroiseet al. Frontiers in Genetics, 2020, 11, pp.581594. ⟨10.3389/fgene.2020.581594⟩ Article dans une revue cea-04419427v1
Where are the missing gene defects in inherited retinal disorders? Intronic and synonymous variants contribute at least to 4% of CACNA1F-mediated inherited retinal disorders Christina Zeitz,Christelle Michiels,Marion Neuillé,Christoph Friedburg,Christel Condroyeret al. Human Mutation, 2019, 40 (6), pp.765-787. ⟨10.1002/humu.23735⟩ Article dans une revue hal-02616948v1
Clustering and variable selection evaluation of 13 unsupervised methods for multi-omics data integration Morgane Pierre-Jean,Jean-François Deleuze,Edith Le Floch,Florence Mauger Briefings in Bioinformatics, 2019, ⟨10.1093/bib/bbz138⟩ Article dans une revue cea-02393847v1
Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene–environment interaction study José Oliveira,Rémi Kazma,Edith Le Floch,Meriem Bennabi,Nora Hamdaniet al. International Journal of Bipolar Disorders, 2016, 4 (1), pp.11. ⟨10.1186/s40345-016-0052-6⟩ Article dans une revue cea-04557509v1
Voxelwise multivariate statistics and brain-wide machine learning using the full diffusion tensor. Anne-Laure Fouque,Pierre Fillard,Anne Bargiacchi,Arnaud Cachia,Monica Zilboviciuset al. Med Image Comput Comput Assist Interv, 2011, 14 (Pt 2), pp.9-16 Article dans une revue hal-00700801v1

Rapport (1)

SurvNMF: Non-Negative Matrix Factorization supervised for survival data analysis Vincent Le Goff,Vincent Guillemot,Cathy Philippe,Jean-François Deleuze,Edith Le Flochet al. Institut Pasteur Paris; CEA. 2025 Rapport (rapport de recherche) hal-04975434v1

Poster de conférence (4)

Impact of joint Dimension Reduction methods for survival prediction - extension of a multi-omics benchmark study Vincent Le Goff,Vincent Guillemot,Cathy Philippe,Gwendoline Mendes,Jean‐françois Deleuzeet al. ISMB/ECCB 2025, Jul 2025, Liverpool, United Kingdom Poster de conférence hal-05318178v1
Impact of joint Dimension Reduction methods for survival prediction - Extension of a multi-omics benchmark study Vincent Le Goff,Vincent Guillemot,Cathy Philippe,Gwendoline Mendes,Jean-François Deleuzeet al. Journées Ouvertes en Biologie, Informatique et Mathématiques (JOBIM), Jun 2024, Toulouse, France Poster de conférence cea-04734003v1
Benchmark study of Adaptive Sampling algorithms: Simulation of various viral mixtures Benjamin Vacus,Edith Le Floch,Zuzana Gerber,Jean-François Deleuze,Arnaud Gloaguen Journées Ouvertes en Biologie, Informatique et Mathématiques (JOBIM), Jun 2024, Toulouse, France Poster de conférence cea-04734006v1
A benchmark study of deconvolution methods and target enrichment kits to estimate the proportions of COVID 19 lineages in wastewater samples sequenced with ONT Benjamin VACUS,Marc Délépine,Zuzana Gerber,Florian Sandron,Christian Daviaudet al. he 31st Annual Intelligent Systems For Molecular Biology and the 22nd Annual European Conference on Computational Biology, Jul 2023, Lyon, France Poster de conférence cea-04600532v1

Communication dans un congrès (5)

PIntMF : Une méthode de factorisation matricielle pénalisée pour l'intégration de données multi-omiques Morgane Pierre-Jean,Florence Mauger,Jean-François Deleuze,Edith Le Floch JDS 21 - 52èmes Journées de Statistique de la Société Française de Statistique (SFdS) (reportées en 2021), Jun 2021, Nice, France Communication dans un congrès hal-02945894v1
Multivariate haplotype analysis of 96 sulci opening for 15,612 UK-Biobank subjects S. Karkar,A. Gloaguen,Y. Le Guen,Morgane Pierre-Jean,Claire Dandine-Roullandet al. ISBI 2019 - Proceedings of the IEEE International Symposium on Biomedical Imaging, Apr 2019, Venice, Italy. ⟨10.1109/isbi.2019.8759497⟩ Communication dans un congrès cea-02016827v1
Dimension reduction and regularisation combined with Partial Least Squares in high dimensional imaging-genetics studies Edith Le Floch,Laura Trinchera,Arthur Tenenhaus,Jean-Baptiste Poline,Vincent Frouin PLS'12, May 2012, Houston, United States. CD-ROM Proceedings (8 p.) Communication dans un congrès hal-00752233v1
A Variable Selection via Correlated Component PLS-type Regression Laura Trinchera,Edith Le Floch,Arthur Tenenhaus 8th Scientific Meeting of the CLAssification and Data Analysis Group of the Italian Statistical Society (GLADAG'11), Sep 2011, Pavia, Italy. 4 p Communication dans un congrès hal-00656584v1
Variable Selection in Partial Least Squares Methods: overview and recent developments Laura Trinchera,Edith Le Floch,Arthur Tenenhaus International Symposium on Business and Industrial Statistics (ISBI'10), Jul 2010, Portoroz, Slovenia. pp.102 Communication dans un congrès hal-00529791v1

Chapitre d'ouvrage (1)

Dimension Reduction and Regularization Combined with Partial Least Squares in High Dimensional Imaging Genetics Studies Edith Le Floch,Laura Trinchera,Vincent Guillemot,Arthur Tenenhaus,Jean-Baptiste Polineet al. New Perspectives in Partial Least Squares and Related Methods, Springer, pp.147-158, 2013, Springer Proceedings in Mathematics & Statistics, ⟨10.1007/978-1-4614-8283-3_9⟩ Chapitre d'ouvrage istex hal-01068983v1