Emeline Nandrot Chef d'Equipe, CR1 CNRS, Institut de la Vision, Paris, France

Identifiants chercheurs

IdHAL :

emeline-nandrot

ORCID :

0000-0003-3087-078X

IdRef :

074075462

ResearcherID :

AAN-3925-2020

Publications

Pré-publication, Document de travail (3)

Loss of ciliary proteins IFT20 and IFT88 results in defective phagocytosis and metabolism in the RPE Peter Andreas Matthiessen,Lotta Elisabeth Wagner,Karsten Boldt,Gunnar Glaßer,Ingo Lieberwirthet al. 2025 Pré-publication, Document de travail hal-05363662v1
Energetic failure and oxidative stress underlie the Prpf31 splicing factor-related mouse phenotype Florian Hamieh,Elora Vanoni,Quentin Rieu,Julie Enderlin,Nawel Hadjoutet al. 2025 Pré-publication, Document de travail hal-05363694v1
Energetic failure and oxidative stress underlie the phenotype of the Prpf31 adRP gene in mice Abdallah Hamieh,Elora Vanoni,Nawel Hadjout,Déborah Lew,Géraldine Millet-Puelet al. 2019 Pré-publication, Document de travail hal-02408316v1

Article dans une revue (36)

Retinal atrophy, inflammation, phagocytic and metabolic disruptions develop in the MerTK-cleavage-resistant mouse model Julie Enderlin,Quentin Rieu,Salomé Réty,Elora M Vanoni,Solène Rouxet al. Frontiers in Neuroscience, 2024, 18, ⟨10.3389/fnins.2024.1256522⟩ Article dans une revue hal-04563541v1
Gas6 and Protein S Ligands Cooperate to Regulate MerTK Rhythmic Activity Required for Circadian Retinal Phagocytosis Célia Parinot,Jonathan Chatagnon,Quentin Rieu,Solène Roux,Dorine Néelet al. International Journal of Molecular Sciences, 2024, 25 (12), pp.6630. ⟨10.3390/ijms25126630⟩ Article dans une revue inserm-04799289v1
Deletion of IFT20 exclusively in the RPE ablates primary cilia and leads to retinal degeneration. Ablation of primary cilia exclusively in the RPE leads to retinal degeneration and visual impairment Viola Kretschmer,Sandra Schneider,Peter A. Matthiessen,Dominik Reichert,Nathan Hotalinget al. PLoS Biology, In press, 21 (12), pp.e3002402. ⟨10.1371/journal.pbio.3002402⟩ Article dans une revue inserm-04292959v1
Pleiotropic Roles of Scavenger Receptors in Circadian Retinal Phagocytosis: A New Function for Lysosomal SR-B2/LIMP-2 at the RPE Cell Surface Quentin Rieu,Antoine Bougoüin,Yvrick Zagar,Jonathan Chatagnon,Abdallah Hamiehet al. International Journal of Molecular Sciences, 2022, 23 (7), pp.3445. ⟨10.3390/ijms23073445⟩ Article dans une revue inserm-03814298v1
Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined with gene augmentation rescue Amélie Rodrigues,Amélie Slembrouck-Brec,Céline Nanteau,Angélique Terray,Yelyzaveta Tymoshenkoet al. NPJ Regenerative medicine, 2022, 7, pp.39. ⟨10.1038/s41536-022-00235-6⟩ Article dans une revue hal-03774125v1
Lack of the antioxidant enzyme methionine sulfoxide reductase A in mice impairs RPE phagocytosis and causes photoreceptor cone dysfunction Francesca Mazzoni,Ying Dun,Jade A Vargas,Emeline Nandrot,Silvia C Finnemann Redox Biology, 2021, pp.101918. ⟨10.1016/j.redox.2021.101918⟩ Article dans une revue hal-03163479v1
A Splice Variant in SLC16A8 Gene Leads to Lactate Transport Deficit in Human iPS Cell-Derived Retinal Pigment Epithelial Cells Laurence Klipfel,Marie Cordonnier,Léa Thiébault,Emmanuelle Clérin,Frédéric Blondet al. Cells, 2021, 10 (1), pp.179. ⟨10.3390/cells10010179⟩ Article dans une revue hal-03131049v1
Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells Alvaro Plaza Reyes,Sandra Petrus-Reurer,Sara Padrell Sánchez,Pankaj Kumar,Iyadh Douagiet al. Nature Communications, 2020, 11 (1), pp.1609. ⟨10.1038/s41467-020-15326-5⟩ Article dans une revue inserm-02648422v2
Preclinical safety studies of human embryonic stem cell‐derived retinal pigment epithelial cells for the treatment of age‐related macular degeneration Sandra Petrus-Reurer,Pankaj Kumar,Sara Padrell Sánchez,Monica Aronsson,Helder Andréet al. Stem Cells Translational Medicine, 2020, 9, pp.936 - 953. ⟨10.1002/sctm.19-0396⟩ Article dans une revue hal-03086697v1
Cohen Syndrome-Associated Cataract Is Explained by VPS13B Functions in Lens Homeostasis and Is Modified by Additional Genetic Factors Vincent Lhussiez,Elisabeth Dubus,Quénol Cesar,Niyazi Acar,Emeline F Nandrotet al. Investigative Ophthalmology & Visual Science, 2020, 61 (11), pp.18. ⟨10.1167/iovs.61.11.18⟩ Article dans une revue hal-02969762v1
Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation Sara Touhami,Fanny Beguier,Sébastien Augustin,Hugo Charles-Messance,Lucile Vignaudet al. Journal of Neuroinflammation, 2018, 15 (1), pp.85. ⟨10.1186/s12974-018-1106-8⟩ Article dans une revue inserm-01736588v1
Collectin-11 Is an Important Modulator of Retinal Pigment Epithelial Cell Phagocytosis and Cytokine Production Xia Dong,Weiju Wu,Liang Ma,Chengfei Liu,Mohajeet B Bhuckoryet al. Journal of Innate Immunity, 2017, 9, pp.529 - 545. ⟨10.1159/000478042⟩ Article dans une revue hal-03086718v1
Generation of Storable Retinal Organoids and Retinal Pigmented Epithelium from Adherent Human iPS Cells in Xeno-Free and Feeder-Free Conditions Sacha Reichman,Amélie Slembrouck,Giuliana Gagliardi,Antoine Chaffiol,Angélique Terrayet al. STEM CELLS, 2017, ⟨10.1002/stem.2586⟩ Article dans une revue hal-01480587v1
Otx2- genetically modified retinal pigment epithelial cells rescue photoreceptors after transplantation Christo Kole,Laurence Klipfel,Ying Yang,Vanessa Ferracane,Frédéric Blondet al. Molecular Therapy, 2017, ⟨10.1016/j.ymthe.2017.09.007⟩ Article dans une revue hal-01611959v1
Cleavage of Mer Tyrosine Kinase (MerTK) from the Cell Surface Contributes to the Regulation of Retinal Phagocytosis Ah-Lai Law,Célia Parinot,Jonathan Chatagnon,Basile Gravez,José-Alain Sahelet al. Journal of Biological Chemistry, 2015, 290 (8), pp.4941-4952. ⟨10.1074/jbc.M114.628297⟩ Article dans une revue hal-03086745v1
From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium Sacha Reichman,Angélique Terray,Amélie Slembrouck,Céline Nanteau,Gaël Orieuxet al. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111, pp.8518 - 8523. ⟨10.1073/pnas.1324212111⟩ Article dans une revue hal-03086749v1
Mutations in Pre-mRNA Processing Factors 3, 8, and 31 Cause Dysfunction of the Retinal Pigment Epithelium Michael H Farkas,Deborah S Lew,Maria E Sousa,Kinga Bujakowska,Jonathan Chatagnonet al. American Journal of Pathology, 2014, 184, pp.2641 - 2652. ⟨10.1016/j.ajpath.2014.06.026⟩ Article dans une revue hal-03086747v1
Large-Scale Purification of Porcine or Bovine Photoreceptor Outer Segments for Phagocytosis Assays on Retinal Pigment Epithelial Cells Célia Parinot,Quentin Rieu,Jonathan Chatagnon,Silvia C. Finnemann,Emeline F. Nandrot Journal of visualized experiments : JoVE, 2014 Article dans une revue hal-03086746v1
CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. Florian Sennlaub,Constance Auvynet,Bertrand Calippe,Sophie Lavalette,Lucie Poupelet al. EMBO Molecular Medicine, 2013, 5 (11), pp.1775-93. ⟨10.1002/emmm.201302692⟩ Article dans une revue inserm-00912837v1
Disease-Causing Mutations in BEST1 Gene Are Associated with Altered Sorting of Bestrophin-1 Protein Jordan A. Doumanov,Christina Zeitz,Paloma Dominguez Gimenez,Isabelle Audo,Abhay Krishnaet al. International Journal of Molecular Sciences, 2013, 14 (7), pp.15121-15140. ⟨10.3390/ijms140715121⟩ Article dans une revue hal-01583466v1
Retinal pigment epithelial cells use a MerTK-dependent mechanism to limit the phagocytic particle binding activity of αvβ5 integrin Emeline Nandrot,Kathryn E Silva,Christina Scelfo,Silvia C Finnemann Biology of the Cell, 2012, 104, pp.326 - 341. ⟨10.1111/boc.201100076⟩ Article dans une revue hal-03086754v1
The Signalling Role of the αvβ5-Integrin Can Impact the Efficacy of AAV in Retinal Gene Therapy Thérèse Cronin,Daniel Chung,Ying Yang,Emeline Nandrot,Jean Bennett Pharmaceuticals, 2012, 5 (5), pp.447 - 459. ⟨10.3390/ph5050447⟩ Article dans une revue inserm-02894109v1
Dietary antioxidants prevent age-related retinal pigment epithelium actin damage and blindness in mice lacking αvβ5 integrin Chia-Chia Yu,Emeline Nandrot,Ying Dun,Silvia C Finnemann Free Radical Biology and Medicine, 2011, 52, pp.660 - 670. ⟨10.1016/j.freeradbiomed.2011.11.021⟩ Article dans une revue hal-03086755v1
Three Gene-Targeted Mouse Models of RNA Splicing Factor RP Show Late-Onset RPE and Retinal Degeneration John J. Graziotto,Michael Farkas,Kinga Bujakowska,Bertrand M. Deramaudt,Qi Zhanget al. Investigative Ophthalmology & Visual Science, 2011 Article dans une revue hal-03086760v1
In vitro differentiation of retinal pigment epithelium from adult retinal stem cells Claudia Aruta,Francesca Giordano,Anna de Marzo,Antonella Comitato,Graça Raposoet al. Pigment Cell & melanoma research, 2010, 24 (1), pp.233 - 240. ⟨10.1111/j.1755-148x.2010.00793.x⟩ Article dans une revue istex hal-03086757v1
EYS is a major gene for rod-cone dystrophies in France Isabelle Audo,José-Alain Sahel,Saddek Mohand-Saïd,Marie-Elise Lancelot,Aline Antonioet al. Human Mutation, 2010, 31 (5), ⟨10.1002/humu.21249⟩ Article dans une revue hal-00552377v1
TRPM1 Is Mutated in Patients with Autosomal-Recessive Complete Congenital Stationary Night Blindness Isabelle Audo,Susanne Kohl,Bart P Leroy,Francis L Munier,Xavier Guillonneauet al. American Journal of Human Genetics, 2009, 85, pp.720 - 729. ⟨10.1016/j.ajhg.2009.10.013⟩ Article dans une revue hal-03086762v1
Lack of v 5 Integrin Receptor or Its Ligand MFG-E8: Distinct Effects on Retinal Function Emeline F. Nandrot,Silvia C. Finnemann Ophthalmic Research, 2008 Article dans une revue hal-03086766v1
Essential role for MFG-E8 as ligand for ␣v␤5 integrin in diurnal retinal phagocytosis Emeline Nandrot,Monika Anand,Dena Almeida,Kamran Atabai,Dean Sheppardet al. Proceedings of the National Academy of Sciences of the United States of America, 2007 Article dans une revue hal-03086772v1
Novel role for alphavbeta5-integrin in retinal adhesion and its diurnal peak Emeline F. Nandrot,Monika Anand,Mousumi Sircar,Silvia C. Finnemann American Journal of Physiology - Cell Physiology, 2006 Article dans une revue hal-03086780v1
Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoter. Alexis-Pierre Bemelmans,Sébastien Bonnel,Leila Houhou,Noëlle Dufour,Emeline Nandrotet al. The Journal of Gene Medicine, 2005, 7 (10), pp.1367-1374. ⟨10.1002/jgm.788⟩ Article dans une revue hal-00187439v1
Loss of Synchronized Retinal Phagocytosis and Age-related Blindness in Mice Lacking alphavbeta5 Integrin Emeline F. Nandrot,Yoonhee Kim,Scott E. Brodie,Xiaozhu Huang,Dean Sheppardet al. Journal of Experimental Medicine, 2004 Article dans une revue hal-03086798v1
Identification of novel genes and altered signaling pathways in the retinal pigment epithelium during the Royal College of Surgeons rat retinal degeneration Eric M. Dufour,Emeline Nandrot,Dominique Marchant,Loic van den Berghe,Stéphanie Gadinet al. Neurobiology of Disease, 2003, pp.166-180 Article dans une revue hal-03086809v1
Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts Emeline Nandrot,Christine Slingsby,A Basak,M Cherif-Chefchaouni,B Benazzouzet al. Journal of Medical Genetics, 2003 Article dans une revue hal-03086814v1
Evidence of clinical and genetic heterogeneity in autosomal dominant congenital cerulean cataracts Latifa Hilal,Emeline Nandrot,Mohamed Belmekki,Siham El Bacha,Mohamed Chefchaouniet al. Ophthalmic Genetics, 2002 Article dans une revue hal-03086816v1
Homozygous Deletion in the Coding Sequence of the c-mer Gene in RCS Rats Unravels General Mechanisms of Physiological Cell Adhesion and Apoptosis Emeline Nandrot,Eric Dufour,Alexandra C Provost,Marie O Péquignot,Sébastien Bonnelet al. Neurobiology of Disease, 2000, 7, pp.586 - 599. ⟨10.1006/nbdi.2000.0328⟩ Article dans une revue istex hal-03086817v1

Chapitre d'ouvrage (4)

The Retinal Pigment Epithelium: Cells That Know the Beat! Elora M Vanoni,Emeline F Nandrot Retinal Degenerative Diseases XIX, 1415, Springer International Publishing, pp.539-545, 2023, Advances in Experimental Medicine and Biology, 978-3-031-27680-4. ⟨10.1007/978-3-031-27681-1_79⟩ Chapitre d'ouvrage inserm-04313839v1
Retinal pigment epithelial cells: the unveiled component in the etiology of Prpf splicing factor-associated retinitis pigmentosa Abdallah Hamieh,Emeline F. Nandrot Advances in Experimental Medicine and Biology, 1185, Springer International Publishing AG, pp.227-231, 2019, Retinal Degenerative Diseases - Mechanisms and Experimental Therapy Chapitre d'ouvrage hal-02408306v1
Retinal pigment epithelial cells: super phagocytes with a rhythm Abdallah Hamieh,Emeline F. Nandrot Cell Biology Research Progress, "Phagocytosis: Overview, History and Role in Human Health and Disease", 2018 Chapitre d'ouvrage hal-02408266v1
Opposite roles of MerTK ligands Gas6 and Protein S during retinal phagocytosis Emeline F. Nandrot Advances in Experimental Medicine and Biology, 1074, Springer International Publishing AG, pp.577-583, 2018, Retinal Degenerative Diseases Chapitre d'ouvrage hal-02408253v1