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Emmanuelle Bignon

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Publications

Cysteine hyperoxidation rewires communication pathways in the nucleosome and destabilizes the dyad

Yasaman Karami , Emmanuelle Bignon
Computational and Structural Biotechnology Journal, 2024, 23, pp.1387-1396. ⟨10.1016/j.csbj.2024.03.025⟩
Journal articles hal-04567034v1
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Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction

Romain Amador , Jean-Jacques Vasseur , Gabriel Birkuš , Emmanuelle Bignon , Antonio Monari
Organic Letters, 2024, 26 (4), pp.819-823. ⟨10.1021/acs.orglett.3c03908⟩
Journal articles hal-04426596v1
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Binding to nucleosome poises human SIRT6 for histone H3 deacetylation

Ekaterina Smirnova , Emmanuelle Bignon , Patrick Schultz , Gabor Papai , Adam Ben Shem
eLife, 2024, 12, ⟨10.7554/elife.87989⟩
Journal articles hal-04487439v1

Resolving a guanine-quadruplex structure in the SARS-CoV-2 genome through circular dichroism and multiscale molecular modeling

Luisa d'Anna , Tom Miclot , Emmanuelle Bignon , Ugo Perricone , Giampaolo Barone
Chemical Science, 2023, 14 (41), pp.11332-11339. ⟨10.1039/d3sc04004f⟩
Journal articles hal-04487444v1

Predicting the three-dimensional structure of the c-KIT proto-oncogene promoter and the dynamics of its strongly coupled guanine quadruplexes

Emmanuelle Bignon , Angelo Spinello , Tom Miclot , Luisa D’anna , Cosimo Ducani
Journal of Physical Chemistry Letters, 2023, 14 (20), pp.4704-4710. ⟨10.1021/acs.jpclett.3c00765⟩
Journal articles hal-04258965v1

How SARS-CoV-2 alters the regulation of gene expression in infected cells

Emmanuelle Bignon , Stéphanie Grandemange , Elise Dumont , Antonio Monari
Journal of Physical Chemistry Letters, 2023, 14 (13), pp.3199-3207. ⟨10.1021/acs.jpclett.3c00582⟩
Journal articles hal-04258968v1

Revealing the Molecular Interactions between Human ACE2 and the Receptor Binding Domain of the SARS-CoV-2 Wild-Type, Alpha and Delta Variants

Cécilia Hognon , Emmanuelle Bignon , Antonio Monari , Marco Marazzi , Cristina Garcia-Iriepa
International Journal of Molecular Sciences, 2023, 24 (3), pp.2517. ⟨10.3390/ijms24032517⟩
Journal articles hal-04150197v1
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Robust AMBER Force Field Parameters for Glutathionylated Cysteines

Zineb Elftmaoui , Emmanuelle Bignon
International Journal of Molecular Sciences, 2023, 24 (19), pp.15022. ⟨10.3390/ijms241915022⟩
Journal articles hal-04487434v1

Mechanism of the covalent inhibition of human transmembrane protease serine 2 as an original antiviral strategy

Angelo Spinello , Luisa D’anna , Emmanuelle Bignon , Tom Miclot , Stéphanie Grandemange
Journal of Physical Chemistry B, 2023, 127 (28), pp.6287-6295. ⟨10.1021/acs.jpcb.3c02910⟩
Journal articles hal-04258941v1

Molecular Basis of the pH-Controlled Maturation of the Tick-Borne Encephalitis Flavivirus

Emmanuelle Bignon , Elise Dumont , Antonio Monari
Journal of Physical Chemistry Letters, 2023, 14 (7), pp.1977-1982. ⟨10.1021/acs.jpclett.2c03551⟩
Journal articles hal-04487441v1

Understanding the interactions of Guanine‐Quadruplexes with peptides as novel strategies for diagnosis or tuning biological functions

Tom Miclot , Aurane Froux , Luisa d’Anna , Emmanuelle Bignon , Stéphanie Grandemange
ChemBioChem, 2023, 24 (6), pp.e202200624. ⟨10.1002/cbic.202200624⟩
Journal articles hal-03925526v1

Modeling the Enzymatic Mechanism of the SARS-CoV-2 RNA-Dependent RNA Polymerase by DFT/MM-MD: An Unusual Active Site Leading to High Replication Rates

Emmanuelle Bignon , Antonio Monari
Journal of Chemical Information and Modeling, 2022, 62 (17), pp.4261-4269. ⟨10.1021/acs.jcim.2c00802⟩
Journal articles hal-04487454v1

Hijacking of Cellular Functions by Severe Acute Respiratory Syndrome Coronavirus-2. Permeabilization and Polarization of the Host Lipid Membrane by Viroporins

Emmanuelle Bignon , Marco Marazzi , Antonio Monari
Journal of Physical Chemistry Letters, 2022, 13 (21), pp.4642-4649. ⟨10.1021/acs.jpclett.2c01102⟩
Journal articles hal-04487448v1

How Fragile We Are: Influence of Stimulator of Interferon Genes (STING) Variants on Pathogen Recognition and Immune Response Efficiency

Jeremy Morere , Cécilia Hognon , Tom Miclot , Tao Jiang , Elise Dumont
Journal of Chemical Information and Modeling, 2022, 62 (12), pp.3096-3106. ⟨10.1021/acs.jcim.2c00315⟩
Journal articles hal-04157319v1

G‐quadruplex recognition by DARPIns through epitope/paratope analogy

Tom Miclot , Emmanuelle Bignon , Alessio Terenzi , Stéphanie Grandemange , Giampaolo Barone
Chemistry - A European Journal, 2022, 28 (57), pp.e202201824. ⟨10.1002/chem.202201824⟩
Journal articles hal-03925664v1

Autophagy and evasion of the immune system by SARS-CoV-2. Structural features of the non-structural protein 6 from wild type and Omicron viral strains interacting with a model lipid bilayer

Emmanuelle Bignon , Marco Marazzi , Stéphanie Grandemange , Antonio Monari
Chemical Science, 2022, 13 (20), pp.6098-6105. ⟨10.1039/d2sc00108j⟩
Journal articles hal-03925667v1

Exploring Dihydroflavonol‐4‐Reductase Reactivity and Selectivity by QM/MM‐MD Simulations

Julien Diharce , Emmanuelle Bignon , Sébastien Fiorucci , Serge Antonczak
ChemBioChem, 2022, 23 (3), ⟨10.1002/cbic.202100553⟩
Journal articles hal-03599132v1

Structure of the 5′ untranslated region in SARS-CoV-2 genome and its specific recognition by innate immune system via the human oligoadenylate synthase 1

Emmanuelle Bignon , Tom Miclot , Alessio Terenzi , Giampaolo Barone , Antonio Monari
Chemical Communications, 2022, 58 (13), pp.2176-2179. ⟨10.1039/D1CC07006A⟩
Journal articles hal-04487446v1
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Never cared for what they do: High structural stability of Guanine-Quadruplexes in the presence of strand-break damage

Tom Miclot , Cécilia Hognon , Emmanuelle Bignon , Alessio Terenzi , Stéphanie Grandemange
Molecules, 2022, 27 (10), pp.3256. ⟨10.3390/molecules27103256⟩
Journal articles hal-03925687v1

Specific Recognition of the 5′-Untranslated Region of West Nile Virus Genome by Human Innate Immune System

Emmanuelle Bignon , Marco Marazzi , Tom Miclot , Giampaolo Barone , Antonio Monari
Viruses, 2022, 14 (6), pp.1282. ⟨10.3390/v14061282⟩
Journal articles hal-04487450v1

Structure and Dynamics of RNA Guanine Quadruplexes in SARS-CoV-2 Genome. Original Strategies against Emerging Viruses

Tom Miclot , Cécilia Hognon , Emmanuelle Bignon , Alessio Terenzi , Marco Marazzi
Journal of Physical Chemistry Letters, 2021, 12 (42), pp.10277--10283. ⟨10.1021/acs.jpclett.1c03071⟩
Journal articles hal-03786805v1
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A Dynamic View of the Interaction of Histone Tails with Clustered Abasic Sites in a Nucleosome Core Particle

Emmanuelle Bignon , Natacha Gillet , Tao Jiang , Christophe Morell , Elise Dumont
Journal of Physical Chemistry Letters, 2021, 12 (25), pp.6014-6019. ⟨10.1021/acs.jpclett.1c01058⟩
Journal articles hal-03279410v1

The iron maiden. Cytosolic aconitase/IRP1 conformational transition in the regulation of ferritin translation and iron hemostasis

Cécilia Hognon , Emmanuelle Bignon , Guillaume Harle , Nadège Touche , Stéphanie Grandemange
Biomolecules, 2021, 11 (9), pp.1329. ⟨10.3390/biom11091329⟩
Journal articles hal-03503702v1

Molecular Mechanisms Associated with Clustered Lesion-Induced Impairment of 8-oxoG Recognition by the Human Glycosylase OGG1

Tao Jiang , Antonio Monari , Elise Dumont , Emmanuelle Bignon
Molecules, 2021, 26 (21), pp.6465. ⟨10.3390/molecules26216465⟩
Journal articles hal-03786798v1
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Recent smell loss is the best predictor of COVID-19 among individuals with recent respiratory symptoms

Richard C. Gerkin , Kathrin Ohla , Maria G. Veldhuizen , Paule V. Joseph , Christine E. Kelly
Chemical Senses, 2021, 46, pp.bjaa081. ⟨10.1093/chemse/bjaa081⟩
Journal articles hal-03367315v1
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Recognition of a tandem lesion by DNA bacterial formamidopyrimidine glycosylases explored combining molecular dynamics and machine learning

Emmanuelle Bignon , Natacha Gillet , Chen-Hui Chan , Tao Jiang , Antonio Monari
Computational and Structural Biotechnology Journal, 2021, 19, pp.2861-2869. ⟨10.1016/j.csbj.2021.04.055⟩
Journal articles hal-03326585v1
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Smell and taste changes are early indicators of the COVID-19 pandemic and political decision effectiveness

Denis Pierron , Veronica Pereda-Loth , Marylou Mantel , Maëlle Moranges , Emmanuelle Bignon
Nature Communications, 2020, 11 (1), pp.5152. ⟨10.1038/s41467-020-18963-y⟩
Journal articles hal-02978603v2
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Impact of the Nucleosome Histone Core on the Structure and Dynamics of DNA-Containing Pyrimidine–Pyrimidone (6–4) Photoproduct

Eva Matoušková , Emmanuelle Bignon , Victor Claerbout , Tomáš Dršata , Natacha Gillet
Journal of Chemical Theory and Computation, 2020, 16 (9), pp.5972-5981. ⟨10.1021/acs.jctc.0c00593⟩
Journal articles hal-03157488v1
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Nucleosomal embedding reshapes the dynamics of abasic sites

Emmanuelle Bignon , Victor Claerbout , Tao Jiang , Christophe Morell , Natacha Gillet
Scientific Reports, 2020, 10 (1), pp.17314. ⟨10.1038/s41598-020-73997-y⟩
Journal articles hal-03157466v1

Bismuth Concentrations in Patients Treated in Real-Life Practice with a Bismuth Subcitrate-Metronidazole-Tetracycline Preparation: The SAPHARY Study

Estelle Guiard , Bénédicte Lelièvre , Magali Rouyer , Frank Zerbib , Bertrand Diquet
Drug Safety, 2019, 42 (8), pp.993-1003. ⟨10.1007/s40264-019-00821-6⟩
Journal articles hal-02483136v1
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Wetting the lock and key enthalpically favours polyelectrolyte binding

Emeric Jeamet , Jean Septavaux , Alexandre Héloin , Marion Donnier-Marechal , Melissa Dumartin
Chemical Science, 2018, 10, pp.277-283. ⟨10.1039/C8SC02966K⟩
Journal articles hal-01917669v1

Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process

Emmanuelle Bignon , Marco Marazzi , Vanessa Besancenot , Hugo Gattuso , Guillaume Drouot
Scientific Reports, 2017, 7, pp. Article Number: 8885 ⟨10.1038/s41598-017-09406-8⟩
Journal articles hal-01583391v1

Conformational polymorphism or structural invariance in DNA photoinduced lesions: implications for repair rates

François Dehez , Hugo Gattuso , Emmanuelle Bignon , Christophe Morell , Elise Dumont
Nucleic Acids Research, 2017, 45 (7), pp.3654-3662. ⟨10.1093/nar/gkx148⟩
Journal articles hal-01518937v1
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Interstrand cross-linking implies contrasting structural consequences for DNA: insights from molecular dynamics

Emmanuelle Bignon , Tomáš Dršata , Christophe Morell , Filip Lankaš , Elise Dumont
Nucleic Acids Research, 2017, 45 (4), pp.2188-2195. ⟨10.1093/nar/gkw1253⟩
Journal articles hal-01449663v1

Molecular Dynamics Insights into Polyamine-DNA Binding Modes: Implications for Cross-Link Selectivity

Emmanuelle Bignon , Chen-Hui Chan , Christophe Morell , Antonio Monari , Jean-Luc Ravanat
Chemistry - A European Journal, 2017, 23 (52), pp.12845-12852. ⟨10.1002/chem.201702065⟩
Journal articles hal-01646327v1

Probing the reactivity of singlet oxygen with purines

Elise Dumont , Raymond Grüber , Emmanuelle Bignon , Christophe Morell , Yohann Moreau
Nucleic Acids Research, 2016, 44 (1), pp.56-62. ⟨10.1093/nar/gkv1364⟩
Journal articles hal-01271590v1

Repair Rate of Clustered Abasic DNA Lesions by Human Endonuclease: Molecular Bases of Sequence Specificity

Hugo Gattuso , Elodie Durand , Emmanuelle Bignon , Christophe Morell , Alexandros G. Georgakilas
Journal of Physical Chemistry Letters, 2016, 7 (19), pp.3760-3765. ⟨10.1021/acs.jpclett.6b01692⟩
Journal articles hal-01449702v1

Singlet Oxygen Attack on Guanine: Reactivity and Structural Signature within the B-DNA Helix

Elise Dumont , Raymond Grüber , Emmanuelle Bignon , Christophe Morell , Juan Aranda
Chemistry - A European Journal, 2016, 22 (35), pp.12358-12362. ⟨10.1002/chem.201601287⟩
Journal articles hal-01449792v1
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Correlation of bistranded clustered abasic DNA lesion processing with structural and dynamic DNA helix distortion

Emmanuelle Bignon , Hugo Gattuso , Christophe Morell , François Dehez , Alexandros G. Georgakilas
Nucleic Acids Research, 2016, 44 (18), pp.8588-8599. ⟨10.1093/nar/gkw773⟩
Journal articles hal-01449647v1

Insights into the chemical meanings of the reaction electronic flux

Christophe Morell , Vincent Tognetti , Emmanuelle Bignon , Elise Dumont , Noemi Hernandez-Haro
Theoretical Chemistry Accounts: Theory, Computation, and Modeling, 2015, 134 (11), pp.133. ⟨10.1007/s00214-015-1730-7⟩
Journal articles hal-01363815v1

DNA Photosensitization by an "Insider": Photophysics and Triplet Energy Transfer of 5-Methyl-2-pyrimidone Deoxyribonucleoside

Emmanuelle Bignon , Hugo Gattuso , Christophe Morell , Elise Dumont , Antonio Monari
Chemistry - A European Journal, 2015, 21 (32), pp.11509-11516. ⟨10.1002/chem.201501212⟩
Journal articles hal-01186698v1

Computational insights into DNA lesions: sequence effects in and out of the nucleosome

Emmanuelle Bignon , Elise Dumont
Network analysis to elucidate natural system dynamics, diversity and performance - CECAM workshop, May 2019, Lyon, France
Conference papers hal-02308301v1

Molecular dynamics insights for DNA lesions in oligonucleotides and nucleosomal DNA

Emmanuelle Bignon , Elise Dumont
Huitième réunion annuelle du GdR Architecture et Dynamique Nucléaires (ADN), Mar 2019, Lyon, France
Conference papers hal-02124544v1

Structure and reactivity of complex DNA lesions: clustered abasic sites as a case study

Emmanuelle Bignon , Christophe Morell , Elise Dumont
21e congrès du GGMM, Apr 2019, Nice, France
Conference papers hal-02308222v1

CNES activities on polynomial chaos expansion for uncertainty propagation

Vincent Morand , Pierre Mercier , Guillaume Prigent , Emmanuelle Bignon , Pietro Marco Congedo
27th AAS/AIAA Space Flight Mechanics Meeting, Feb 2017, San Antonio, United States
Conference papers hal-01378431v1

Modélisation de structures d'ADN endommagé : un microscope computationnel

Emmanuelle Bignon , Raymond Grüber , Elise Dumont , Christophe Morell , Jean-Luc Ravanat
Forum de la recherche en cancérologie Rhône-Alpes Auvergne, Mar 2016, Lyon, France
Conference papers hal-01297487v1

Modelling the structure and triplet-triplet energy transfer of the 6-4 photoproduct

Emmanuelle Bignon , Hugo Gattuso , Christophe Morell , Antonio Monari , Elise Dumont
Joint Congress of the French and Italian Photochemists and Photobiologists 2016, Sep 2016, Bari, Italy
Conference papers hal-01488339v1

MODELLING THE INTERSTRAND CROSS-LINKS IMPACT ON DNA STRUCTURE

Emmanuelle Bignon , Tomáš Dršata , Elise Dumont , Christophe Morell , Filip Lankaš
14th International Workshop on Radiation Damage to DNA, Mar 2016, Melbourne, Australia
Conference papers hal-01490046v1

Abasic Sites Impact on DNA Structure and Interstrand Cross-Links Generation Modelling

Emmanuelle Bignon , Christophe Morell , Elise Dumont
COST Action CM1201 : Biomimetic Radical Chemistry & ClicGene , Mar 2016, Grenoble, France
Conference papers hal-01490054v1
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Insights into DNA lesions formation and structural outcome by simulation tools

Elise Dumont , Chen-Hui Chan , Emmanuelle Bignon , François Dehez , Antonio Monari
Fifteenth edition of the international Workshop on Radiation Damage to DNA, May 2018, Aussois, France
Conference poster hal-02114267v1

Probing Interstand CrossLinks Impact on DNA Structure by Classical Molecular Dynamics Simulations

Emmanuelle Bignon , Christophe Morell , Elise Dumont
Forum de la Recherche en Cancérologie Auvergne-Rhône-Alpes 2017, Apr 2017, Lyon, France
Conference poster hal-01504781v1

A moveable feast. Molecular modeling and simulation unraveling cross-talks between RNA structure and its biological role

Aurane Froux , Emmanuelle Bignon , Guillaume Harlé , Stéphanie Grandemange , Antonio Monari
RNA Structure and Function, 14, Springer International Publishing, pp.279-294, 2023, RNA Technologies, ⟨10.1007/978-3-031-36390-0_13⟩
Book sections hal-04316714v1

CHAPTER 6. Influence of DNA Structure on Lesion Formation and Repair: Role of Modelling and Simulations

Natacha Gillet , Emmanuelle Bignon , Elise Dumont , Antonio Monari
Improta, Roberto and Douki, Thierry. Comprehensive Series in Photochemical & Photobiological Sciences, Royal Society of Chemistry, pp.105--132, 2021, 978-1-83916-196-4. ⟨10.1039/9781839165580-00105⟩
Book sections hal-03786795v1