Etienne Lefai

Identifiants chercheurs

IdHAL :

etienne-lefai

ORCID :

0000-0002-3042-7801

IdRef :

111726212

Publications

Article dans une revue (81)

The Preservation of Muscle Mitochondrial Machinery During Hypometabolic Hibernation in Scandinavian Brown Bears (Ursus arctos) Audrey Bergouignan,John Noone,Charlotte Brun,Laura Cussonneau,Alexandre Geffroyet al. Acta Physiologica, In press, ⟨10.1111/apha.70177⟩ Article dans une revue hal-05527807v1
Structure predictions of MuRF 1‐ UBE2 complexes identify amino acid residues governing interaction selectivity for each MuRF 1‐ E2 pair Agnès Claustre,Mélodie Malige,Maëlys Macheton,Lydie Combaret,Etienne Lefaiet al. FEBS Journal, 2025, 292 (10), pp.2559-2577. ⟨10.1111/febs.70017⟩ Article dans une revue hal-04993910v1
Protein synthesis, autophagy, and regeneration-related signaling in fast/slow muscles in two mammalian models of disuse Xuli Gao,Weilan Miao,Yuting Han,Yingyu Yang,Ning Anet al. Canadian Journal of Zoology, 2025, 103, pp.0061. ⟨10.1139/cjz-2024-0061⟩ Article dans une revue hal-05446749v1
Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth Huali Su,Yaogang Zhong,Liqing He,Feng Geng,Xinmin Yinet al. Science Advances , 2025, 11 (16), ⟨10.1126/sciadv.adq0334⟩ Article dans une revue hal-05446764v1
Reduced ATP turnover during hibernation in relaxed skeletal muscle Cosimo de Napoli,Luisa Schmidt,Mauro Montesel,Laura Cussonneau,Samuele Sannitiet al. Nature Communications, 2025, 16 (1), pp.80. ⟨10.1038/s41467-024-55565-4⟩ Article dans une revue hal-04892800v1
Alterations of lipid homeostasis in morbid obese patients are partly reversed by bariatric surgery Flore Sinturel,Simona Chera,Marie-Claude Brulhart-Meynet,Jonathan Paz Montoya,Etienne Lefaiet al. iScience, 2024, 27 (9), pp.110820. ⟨10.1016/j.isci.2024.110820⟩ Article dans une revue hal-04753955v1
Involvement of Melatonin, Oxidative Stress, and Inflammation in the Protective Mechanism of the Carotid Artery over the Torpor–Arousal Cycle of Ground Squirrels Ziwei Hao,Yuting Han,Qi Zhao,Minghui Zhu,Xiaoxuan Liuet al. International Journal of Molecular Sciences, 2024, 25 (23), pp.12888. ⟨10.3390/ijms252312888⟩ Article dans une revue hal-04892799v1
Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma Yaogang Zhong,Feng Geng,Logan Mazik,Xinmin Yin,Aline Paixao Beckeret al. Cell Reports Medicine, 2024, 5 (9), pp.101706. ⟨10.1016/j.xcrm.2024.101706⟩ Article dans une revue hal-04794783v1
STAT3 activation of SCAP-SREBP-1 signaling upregulates fatty acid synthesis to promote tumor growth Yunzhou Fan,Rui Zhang,Chao Wang,Meixia Pan,Feng Genget al. Journal of Biological Chemistry, 2024, 300 (6), pp.107351. ⟨10.1016/j.jbc.2024.107351⟩ Article dans une revue hal-04892802v1
ANGPTL4 is a potential driver of HCV-induced peripheral insulin resistance Diana Gomes,Cyril Sobolewski,Stéphanie Conzelmann,Tifany Schaer,Etienne Lefaiet al. Scientific Reports, 2023, 13 (1), pp.6767. ⟨10.1038/s41598-023-33728-5⟩ Article dans une revue hal-04176948v1
Differential bone remodeling mechanism in hindlimb unloaded and hibernating Daurian ground squirrels: a comparison between artificial and natural disuse within the same species Xuli Gao,Siqi Wang,Siqi Shen,Shuyao Wang,Manjiang Xieet al. Journal of Comparative Physiology B, 2023, 193 (3), pp.329-350. ⟨10.1007/s00360-023-01482-9⟩ Article dans une revue hal-04288563v1
Integrated transcriptomics and metabolomics reveal protective effects on heart of hibernating Daurian ground squirrels Yingyu Yang,Ziwei Hao,Ning An,Yuting Han,Weilan Miaoet al. Journal of Cellular Physiology, 2023, ⟨10.1002/jcp.31123⟩ Article dans une revue hal-04279721v1
SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells Feng Geng,Yaogang Zhong,Huali Su,Etienne Lefai,Shino Magakiet al. Cell Reports, 2023, 42 (7), pp.112790. ⟨10.1016/j.celrep.2023.112790⟩ Article dans une revue hal-04279038v1
Induction of ATF4-Regulated Atrogenes Is Uncoupled from Muscle Atrophy during Disuse in Halofuginone-Treated Mice and in Hibernating Brown Bears Laura Cussonneau,Cécile Coudy-Gandilhon,Christiane Deval,Ghita Chaouki,Mehdi M. Djelloul-Mazouzet al. International Journal of Molecular Sciences, 2023, 24 (1), pp.621. ⟨10.3390/ijms24010621⟩ Article dans une revue hal-04178468v1
The Protective Effects on Ischemia–Reperfusion Injury Mechanisms of the Thoracic Aorta in Daurian Ground Squirrels (Spermophilus dauricus) over the Torpor–Arousal Cycle of Hibernation Yuting Han,Weilan Miao,Ziwei Hao,Ning An,Yingyu Yanget al. International Journal of Molecular Sciences, 2022, 23 (18), pp.10248. ⟨10.3390/ijms231810248⟩ Article dans une revue hal-03842443v1
Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients J. T. Hannich,U. Loizides-Mangold,F. Sinturel,T. Harayama,B. Vandereyckenet al. Acta Physiologica, 2021, 232 (1), pp.e13610. ⟨10.1111/apha.13610⟩ Article dans une revue inserm-03269069v1
Cardiomyocyte Protection by Hibernating Brown Bear Serum: Toward the Identification of New Protective Molecules Against Myocardial Infarction Lucas Givre,Claire Crola da Silva,Jon E Swenson,Jon M Arnemo,Guillemette Gauquelin-Kochet al. Frontiers in Cardiovascular Medicine, 2021, 8, pp.687501. ⟨10.3389/fcvm.2021.687501⟩ Article dans une revue hal-03419383v1
Hibernating brown bears are protected against atherogenic dyslipidemia Sylvain Giroud,Isabelle Chery,Mathilde Arrivé,Michel Prost,Julie Zumsteget al. Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-98085-7⟩ Article dans une revue hal-03360652v1
Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear Laura Cussonneau,Christian Boyer,Charlotte Brun,Christiane Deval,Emmanuelle Loizonet al. Cells, 2021, 10 (8), pp.1873. ⟨10.3390/cells10081873⟩ Article dans une revue hal-03314541v1
MicroRNAs facilitate skeletal muscle maintenance and metabolic suppression in hibernating brown bears Bryan E. Luu,Etienne Lefai,Sylvain Giroud,Jon E. Swenson,Blandine Chazarinet al. Journal of Cellular Physiology, 2020, 235 (4), pp.3984-3993. ⟨10.1002/jcp.29294⟩ Article dans une revue hal-02349938v1
Specific shifts in the endocannabinoid system in hibernating brown bears Christian Boyer,Laura Cussonneau,Charlotte Brun,Christiane Deval,Jean-Paul Pais de Barroset al. Frontiers in Zoology, 2020, 17, pp.35. ⟨10.1186/s12983-020-00380-y⟩ Article dans une revue hal-03054587v1
ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury Yves Gouriou,Muhammad Rizwan Alam,Zeina Harhous,Claire Crola Da Silva,Delphine Baetzet al. Cells, 2020, Cell Signaling, 9 (12), pp.2542. ⟨10.3390/cells9122542⟩ Article dans une revue hal-03060378v1
Hypergravity as a gravitational therapy mitigates the effects of knee osteoarthritis on the musculoskeletal system in a murine model Benoit Dechaumet,Damien Cleret,Marie-Thérèse Linossier,Arnaud Vanden-Bossche,Stéphanie Chanonet al. PLoS ONE, 2020, 15 (12), pp.e0243098. ⟨10.1371/journal.pone.0243098⟩ Article dans une revue hal-03152504v1
Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) Blandine Chazarin,Anna Ziemianin,Alina L. Evans,Emmanuelle Meugnier,Emmanuelle Loizonet al. Antioxidants , 2019, 8 (9), pp.334. ⟨10.3390/antiox8090334⟩ Article dans une revue hal-02274540v1
Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle Blandine Chazarin,Kenneth B Storey,Anna Ziemianin,Stéphanie Chanon,Marine Plumelet al. Frontiers in Zoology, 2019, 16, pp.12. ⟨10.1186/s12983-019-0312-2⟩ Article dans une revue hal-02149735v1
A nutrient cocktail prevents lipid metabolism alterations induced by 20 days of daily steps reduction and fructose overfeeding: Result from a randomized study Anthony Damiot,Rémi Demangel,John Noone,Isabelle Chery,Alexandre Zaharievet al. Journal of Applied Physiology, 2019, 126 (1), pp.88-101. ⟨10.1152/japplphysiol.00018.2018⟩ Article dans une revue hal-01918097v1
In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes Georg Tascher,Audrey Burban,Sandrine Camus,Marine Plumel,Stéphanie Chanonet al. Cells, 2019, 8 (2), pp.E192. ⟨10.3390/cells8020192⟩ Article dans une revue hal-02050391v1
Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear Sylvain Giroud,Isabelle Chery,Fabrice Bertile,Justine Bertrand-Michel,Georg Tascheret al. Frontiers in Physiology, 2019, 10, pp.389. ⟨10.3389/fphys.2019.00389⟩ Article dans une revue hal-02141629v1
TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia Fabien Vanden Abeele,Sabine Lotteau,Sylvie Ducreux,Charlotte Dubois,Nicole Monnieret al. Genetics in Medicine, 2019, 21 (2), pp.441-450. ⟨10.1038/s41436-018-0066-9⟩ Article dans une revue hal-02475163v1
Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans Emily Tubbs,Stéphanie Chanon,Maud Robert,Nadia Bendridi,Gabriel Bidauxet al. Diabetes, 2018, 67 (4), pp.636-650. ⟨10.2337/db17-0316⟩ Article dans une revue hal-01847407v1
Metabolic inflexibility is an early marker of bed-rest–induced glucose intolerance even when fat mass is stable Floriane Rudwill,Donal O’gorman,Etienne Lefai,Isabelle Chery,Alexandre Zaharievet al. Journal of Clinical Endocrinology and Metabolism, 2018, 103 (5), pp.1910-1920. ⟨10.1210/jc.2017-02267⟩ Article dans une revue hal-01837670v1
Seasonal changes in eicosanoid metabolism in the brown bear Sylvain Giroud,Alina M Evans,Isabelle Chery,Fabrice Bertile,Georg Tascheret al. The Science of Nature Naturwissenschaften, 2018, 105 (9-10), ⟨10.1007/s00114-018-1583-8⟩ Article dans une revue hal-01907890v1
Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle Laurent Perrin,Ursula Loizides-Mangold,Stéphanie Chanon,Cédric Gobet,Nicolas Huloet al. eLife, 2018, 7, pp.30. ⟨10.7554/eLife.34114⟩ Article dans une revue hal-01847497v1
Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells Stéphanie Chanon,Blandine Chazarin,Benoit Toubhans,Christine Durand,Isabelle Cheryet al. Scientific Reports, 2018, 8 (1), pp.1-10. ⟨10.1038/s41598-018-23891-5⟩ Article dans une revue hal-01772255v1
Exercise training improves fat metabolism independent of total energy expenditure in sedentary overweight men, but does not restore lean metabolic phenotype Etienne Lefai,Stéphane Blanc,Iman Momken,Edvina Antoun,Isabelle Cheryet al. International Journal of Obesity, 2017, 41 (12), pp.1728-1736. ⟨10.1038/ijo.2017.151⟩ Article dans une revue hal-01613860v1
Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes S. Chanon,C. Durand,A. Vieille-Marchiset,M. Robert,C. Dibneret al. Journal of visualized experiments : JoVE, 2017, 124, ⟨10.3791/55743⟩ Article dans une revue hal-01848149v1
Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice Bérengère Benoit,Emmanuelle Fouilloux-Meugnier,Martina Castelli,Stéphanie Chanon,Aurélie Vieille-Marchisetet al. Nature Medicine, 2017, 23 (8), pp.990-996. ⟨10.1038/nm.4363⟩ Article dans une revue hal-01827292v1
Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro Ursula Loizides-Mangold,Laurent Perrin,Bart Vandereycken,James Betts,Jean-Philippe Walhinet al. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (41), pp.E8565 - E8574. ⟨10.1073/pnas.1705821114⟩ Article dans une revue hal-01827463v1
Transition from physical activity to inactivity increases skeletal muscle miR-148b content and triggers insulin resistance Caroline Gastebois,Stéphanie Chanon,Sophie Rome,Christine Durand,Elise Pelasciniet al. Physiological Reports, 2016, 4 (17), pp.e12902. ⟨10.14814/phy2.12902⟩ Article dans une revue hal-01398592v1
Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth Peng Ru,Peng Hu,Feng Geng,Xiaokui Mo,Chunming Chenget al. Cell Reports, 2016, 16 (6), pp.1527-1535. ⟨10.1016/j.celrep.2016.07.017⟩ Article dans une revue hal-01850292v1
Multiple microRNA regulation of lipoprotein lipase gene abolished by 3'UTR polymorphisms in a triglyceride-lowering haplotype harboring p.Ser474Ter Cyrielle Caussy,Sybil Charriere,Aline Meirhaeghe,Jean Dallongeville,Etienne Lefaiet al. Atherosclerosis, 2016, 246, pp.280-286. ⟨10.1016/j.atherosclerosis.2016.01.010⟩ Article dans une revue istex hal-01986056v1
Inhibition of SOAT1 suppresses glioblastoma growth via blocking SREBP-1-mediated lipogenesis Feng Geng,Xiang Cheng,Xiaoning Wu,Ji Young Yoo,Chunming Chenget al. Clinical Cancer Research, 2016, 22 (21), pp.5337-5348. ⟨10.1158/1078-0432.CCR-15-2973⟩ Article dans une revue hal-01608883v1
Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men Caroline Gastebois,Clément Villars,Jocelyne Drai,Emmanuelle Canet-Soulas,Stéphane Blancet al. European Journal of Applied Physiology, 2016, 116 (11-12), pp.2135-2144. ⟨10.1007/s00421-016-3466-z⟩ Article dans une revue hal-01382847v1
A TG-associated minor LPL haplotype supresses miR-29 binding on LPL 3'UTR C. Caussy,S. Charrière,J. Dallongeville,Etienne Lefai,V. Euthineet al. Atherosclerosis, 2015, 241 (1), pp.e12. ⟨10.1016/j.atherosclerosis.2015.04.059⟩ Article dans une revue hal-02049002v1
Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation A. Eljaafari,M. Robert,M. Chehimi,S. Chanon,C. Durandet al. Diabetes, 2015, 64 (7), pp.2477-88. ⟨10.2337/db15-0162⟩ Article dans une revue hal-01850502v1
Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion L. Perrin,U. Loizides-Mangold,S. Skarupelova,P. Pulimeno,S. Chanonet al. Molecular metabolism, 2015, 4 (11), pp.834-45. ⟨10.1016/j.molmet.2015.07.009⟩ Article dans une revue hal-01850527v1
Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth C. Cheng,P. Ru,F. Geng,J. Liu,J. Y. Yooet al. Cancer Cell, 2015, 28 (5), pp.569-81. ⟨10.1016/j.ccell.2015.09.021⟩ Article dans une revue hal-01850543v1
Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer Yann S. Gallot,Anne-Cécile Durieux,Josiane Castells,Marine M. Desgeorges,Barbara Vernuset al. Cancer Research, 2014, 74 (24), pp.7344-7356. ⟨10.1158/0008-5472.can-14-0057⟩ Article dans une revue hal-01837578v1
Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans David Patsouris,Jingwei-Ji Cao,Guillaume Vial,Amelie Bravard,Etienne Lefaiet al. PLoS ONE, 2014, 9 (10), pp.e110653. ⟨10.1371/journal.pone.0110653⟩ Article dans une revue hal-01859365v1
Myotube-derived exosomal miRNAs downregulate Sirtuin1 in myoblasts during muscle cell differentiation A. Forterre,A. Jalabert,Karim Chikh,S. Pesenti,V. Euthineet al. Cell Cycle, 2014, 13 (1), pp.78-89. ⟨10.4161/cc.26808⟩ Article dans une revue hal-01859385v1
Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk? A. Forterre,A. Jalabert,Eric Berger,M. Baudet,Karim Chikhet al. PLoS ONE, 2014, 9 (1), pp.e84153. ⟨10.1371/journal.pone.0084153⟩ Article dans une revue hal-01859453v1
A socio-ecological approach promoting physical activity and limiting sedentary behavior in adolescence showed weight benefits maintained 2.5 years after intervention cessation. Chantal Simon,Nadir Kellou,Julien Dugas,Carine Platat,Nane Copinet al. International Journal of Obesity, 2014, 38 (7), pp.936-943. ⟨10.1038/ijo.2014.23⟩ Article dans une revue hal-00985938v1
Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice Hala Aswad,Alexis Forterre,Oscar P. B. Wiklander,Guillaume Vial,Emmanuelle Danty-Bergeret al. Diabetologia, 2014, 57 (10), pp.2155-2164. ⟨10.1007/s00125-014-3337-2⟩ Article dans une revue hal-01376852v1
Effect of enforced physical inactivity induced by 60-d of bed rest on hepatic markers of NAFLD in healthy normal-weight women Floriane Rudwill,Audrey Bergouignan,Caroline Gastebois,Guillemette Gauquelin-Koch,Etienne Lefaiet al. Liver International, 2014, 35 (6), in press. ⟨10.1111/liv.12743⟩ Article dans une revue istex hal-01101639v1
An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site Cyrielle Caussy,S. Charriere,C. Marcais,M. Di Filippo,A. Sassolaset al. American Journal of Human Genetics, 2014, 94 (1), pp.129-34. ⟨10.1016/j.ajhg.2013.12.001⟩ Article dans une revue hal-01859007v1
Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity Stefania Carobbio,Rachel M. Hagen,Christopher J. Lelliott,Marc Slawik,Gema Medina-Gomezet al. Diabetes, 2013, 62 (11), pp.3697 - 3708. ⟨10.2337/db12-1748⟩ Article dans une revue hal-02644218v1
Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling. Rami Jaafar,Joffrey de Larichaudy,Stéphanie Chanon,Vanessa Euthine,Christine Durandet al. Cell Communication and Signaling, 2013, 11 (1), pp.55. ⟨10.1186/1478-811X-11-55⟩ Article dans une revue inserm-00868745v1
A liver Hif-2 alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition Kevin Wei,Stephanie M. Piecewicz,Lisa M. Mcginnis,Cullen M. Taniguchi,Stanley J. Wiegandet al. Nature Medicine, 2013, 19 (10), pp.1331 - +. ⟨10.1038/nm.3295⟩ Article dans une revue hal-02643867v1
Activity energy expenditure is a major determinant of dietary fat oxidation and trafficking, but the deleterious effect of detraining is more marked than the beneficial effect of training at current recommendations. Audrey Bergouignan,Iman Momken,Etienne Lefai,Edwina Antoun,Dale A Schoelleret al. The American Journal of Clinical Nutrition, 2013, 98 (3), pp.648-658. ⟨10.3945/ajcn.112.057075⟩ Article dans une revue hal-00866488v1
Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux. Céline Luquain-Costaz,Etienne Lefai,Maud Arnal-Levron,Daria Markina,Shota Sakaïet al. Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (8), pp.1803-11. ⟨10.1161/ATVBAHA.113.301857⟩ Article dans une revue inserm-00844488v1
TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism. Joffrey de Larichaudy,Alessandra Zufferli,Filippo Serra,Andrea Isidori,Fabio Naroet al. Skeletal Muscle, 2012, 2 (1), pp.2. ⟨10.1186/2044-5040-2-2⟩ Article dans une revue inserm-00694560v1
Validity of combining heart rate and uniaxial acceleration to measure free-living physical activity energy expenditure in young men. Clement Villars,Audrey Bergouignan,Julien Dugas,Edwina Antoun,Dale Alan Schoelleret al. Journal of Applied Physiology, 2012, 113 (11), pp.1763-1771. ⟨10.1152/japplphysiol.01413.2011⟩ Article dans une revue hal-00751256v1
Sirtuin 1 Regulates SREBP-1c Expression in a LXR-Dependent Manner in Skeletal Muscle Aurélia Defour,Kevin Dessalle,Andréa Castro Perez,Thomas Poyot,Josiane Castellset al. PLoS ONE, 2012, 7 (9), pp.e43490. ⟨10.1371/journal.pone.0043490⟩ Article dans une revue hal-01779124v1
SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors. Kevin Dessalle,Vanessa Euthine,Stéphanie Chanon,Joffrey de Larichaudy,Isao Fujiiet al. PLoS ONE, 2012, 7 (11), pp.e50878. ⟨10.1371/journal.pone.0050878⟩ Article dans une revue inserm-00809752v1
Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes. Rami Jaafar,Caroline Zeiller,Luciano Pirola,Antonio Di Grazia,Fabio Naroet al. Journal of Biological Chemistry, 2011, 286 (25), pp.22609-21. ⟨10.1074/jbc.M110.203885⟩ Article dans une revue inserm-00817714v1
FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction. Amélie Bravard,Etienne Lefai,Emmanuelle Fouilloux-Meugnier,Sandra Pesenti,Emmanuel Disseet al. Diabetes, 2011, 60 (1), pp.258-68. ⟨10.2337/db10-0281⟩ Article dans une revue inserm-00809741v1
AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice Yu Li,Shanqin Xu,Maria M. Mihaylova,Bin Zheng,Xiuyun Houet al. Cell Metabolism, 2011, 13 (4), pp.376 - 388. ⟨10.1016/j.cmet.2011.03.009⟩ Article dans une revue hal-02651599v1
GPIHBP1 C89F neomutation and hydrophobic C-terminal domain G175R mutation in two pedigrees with severe hyperchylomicronemia Sybil Charriere,Noël Peretti,Sophie Bernard,Mathilde Di Filippo,Agnes Sassolaset al. Journal of Clinical Endocrinology and Metabolism, 2011, 96 (10), ⟨10.1210/jc.2011-1444⟩ Article dans une revue hal-02652262v1
A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation. Virginie Lecomte,Emmanuelle Meugnier,Vanessa Euthine,Christine Durand,Damien Freyssenetet al. Molecular and Cellular Biology, 2010, 30 (5), pp.1182-98. ⟨10.1128/MCB.00690-09⟩ Article dans une revue inserm-00817651v1
Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia. François Bertrand Favier,Frédéric Costes,Aurélia Defour,Régis Bonnefoy,Etienne Lefaiet al. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 2010, 298 (6), pp.R1659-66. ⟨10.1152/ajpregu.00550.2009⟩ Article dans une revue inserm-00593929v1
A New Role for Sterol Regulatory Element Binding Protein 1 Transcription Factors in the Regulation of Muscle Mass and Muscle Cell Differentiation V. Lecomte,E. Meugnier,V. Euthine,C. Durand,D. Freyssenetet al. Molecular and Cellular Biology, 2010, 30 (5), pp.1182-1198 Article dans une revue hal-01982021v1
FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction A. Bravard,Etienne Lefai,E. Meugnier,S. Pesenti,Emmanuel Disseet al. Diabetes, 2010, 60 (1), pp.258-268 Article dans une revue hal-01982013v1
Pdro, a protein associated with late endosomes and lysosomes and implicated in cellular cholesterol homeostasis. Patricia Guillaumot,Céline Luquain,Mouhannad Malek,Anne-Laure Huber,Sabine Brugièreet al. PLoS ONE, 2010, 5 (6), pp.e10977. ⟨10.1371/journal.pone.0010977⟩ Article dans une revue inserm-00763417v1
The microRNA Signature in Response to Insulin Reveals Its Implication in the Transcriptional Action of Insulin in Human Skeletal Muscle and the Role of a Sterol Regulatory Element-Binding Protein-1c/Myocyte Enhancer Factor 2C Pathway A. Granjon,M.-P. Gustin,Jennifer Rieusset,Etienne Lefai,E. Meugnieret al. Diabetes, 2009, 58 (11), pp.2555-2564 Article dans une revue hal-01982029v1
Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2) Sophie Rome,E. Meugnier,V. Lecomte,V. Berbe,J. Bessonet al. Diabetologia, 2009, 52 (9), pp.1899-1912 Article dans une revue hal-01982031v1
The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathway. Aurélie Granjon,Marie-Paule Gustin,Jennifer Rieusset,Etienne Lefai,Emmanuelle Meugnieret al. Diabetes, 2009, 58 (11), pp.2555-64. ⟨10.2337/db09-0165⟩ Article dans une revue inserm-00808523v1
Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle Sophie Rome,Virginie Lecomte,Emmanuelle Fouilloux-Meugnier,Jennifer Rieusset,Cyrille Debardet al. Physiological Genomics, 2008, 34 (3), pp.327-337 Article dans une revue hal-01982035v1
Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle. Sophie Rome,Virginie Lecomte,Emmanuelle Meugnier,Jennifer Rieusset,Cyrille Debardet al. Physiological Genomics, 2008, 34 (3), pp.327-37. ⟨10.1152/physiolgenomics.90211.2008⟩ Article dans une revue inserm-00809732v1
Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs Nicolas Dif,Vanessa Euthine,Estelle Gonnet,Martine Laville,Hubert Vidalet al. Biochemical Journal, 2006, 400 (1), pp.179-188. ⟨10.1042/BJ20060499⟩ Article dans une revue hal-00478570v1
Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues Yvan Gosmain,Nicolas Dif,Vanessa Euthine,Emmanuelle Loizon,Jennifer J. Rieussetet al. Journal of Lipid Research, 2005, 46 (4), pp.697-705 Article dans une revue hal-02048999v1
Expression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients Etienne Lefai,M. Roques,Nathalie Vega,M. Laville,Hubert Vidal Biochemical Journal, 2001, 360, pp.117-125 Article dans une revue hal-02673828v1

Communication dans un congrès (18)

Innovative approaches for an in- depth quantitative analysis of the serum proteome of brown bears Alexandre Geffroy,Hugo Gizardin-Fredon,Jon Arnemo,Jonas Kindberg,Sarah Cianferaniet al. 72nd ASMS Conference on Mass Spectrometry and Allied Topics, Jun 2024, Anaheim (CA), United States Communication dans un congrès hal-04437952v1
Hibernation and muscle homeostasis Etienne Lefai,Guillaume Fourneaux,Cécile Coudy-Gandilhon,Charlene Pourpe,Jonas Kindberget al. 21èmes Journées de la SFM, Société Francaise de Myologie, Nov 2024, Clermont - Ferrand, France Communication dans un congrès hal-04992070v1
Insights into the Transforming Growth Factor TGF-β superfamily specific modulation: unravelling the impact of hibernating bear serum in primary human muscle cells Lydie Combaret,Richard Chloé,Fourneaux Guillaume,Geffroy Alexandre,Cueff Gwendalet al. Physiology in Focus 2024, Jul 2024, Newcastle upon Tyne, United Kingdom Communication dans un congrès hal-04652515v1
Chromatin dynamics during hibernating in brown bear : Variation of H3K9 methylation Guillaume Fourneaux,Chloé Richard,Christophe Tatout,Aline V. Probst,Cécile Coudy-Gandilhonet al. Journée CIR3- Université Clermont Auvergne, CIR3, Nov 2024, Clermont-ferrand, France Communication dans un congrès hal-04994384v1
Hibernation in brown bears: A model for medical and space research Etienne Lefai,Cécile Coudy-Gandilhon,Fourneaux Guillaume,Chloé Richard,Pourpe Charlèneet al. Physiology in Focus, The Scandinavian Physiological Society (SPS), the Federation of European Physiological Societies (FEPS), and the Baltic Physiological Societies., Sep 2023, Tallinn, Estonia Communication dans un congrès hal-04728848v1
Effect of hibernating bear serum effect on human myotubes transcriptome: BMP signaling regulation Chloé Richard,Guillaume Fourneaux,Alexandre Geffroy,Cécile Coudy-Gandilhon,Gwendal Cueffet al. 6e Congrès de la Société de Physiologie et Biologie Intégrative, Jul 2023, Clermont-Ferrand, France Communication dans un congrès hal-04209952v1
Transcriptional reprogramming during hibernation: Potential role of HR in gene expression. Guillaume Fourneaux,Cécile Coudy-Gandhilon,Charlène Pourpe,Chloé Richard,Laura Cussonneauet al. 6e Congres de Physiologie et Biologie Integrative, Société de Physiologie et de Biologie Intégrative, Jul 2023, Clermont ferrand, France Communication dans un congrès hal-04728696v1
Impact of hibernating bear serum on human cells transcriptome Guillaume Fourneaux,Cécile Coudy-Gandilhon,Laura Cussonneau,Sophie Desset,Aline Probstet al. Journée du Centre International de Recherche 3, I-Site, I-Site UCA, Nov 2022, Clermont -Ferrand, France Communication dans un congrès hal-04728657v1
Fighting muscle loss: lessons from hibernation in brown bear Etienne Lefai,Cécile Coudy-Gandhilon,Laura Cussonneau,Lydie Combaret,Fabrice Bertile SCWD 15th International Conference Cachexia, Sarcopenia and Muscle Wasting 2022, Society of Sarcopenia and Wasting Disorders, Jun 2022, Lisboa, Portugal Communication dans un congrès hal-04728825v1
Concurrent BMP signaling maintenance and TGF- β signaling inhibition is a hallmark of natural resistance to muscle atrophy Laura Cussonneau,Christian Boyer,Emmanuelle Meugnier,Guillemette Gauquelin-Koch,Jon Arnemoet al. Congrès des jeunes chercheurs en Biologie de la région AURA, Jun 2021, Lyon ( virtual ), France Communication dans un congrès hal-04209580v1
Concurrent BMP maintenance and TGFβ inhibition is a hallmark of bear resistance to muscle atrophy Laura Cussonneau,Emeric Dubois,Jon Arnemo,Fabrice Bertile,Lydie Combaretet al. 16th International Hibernation Symposium, Aug 2021, Groningen, The Netherlands, France Communication dans un congrès hal-04209832v1
Concurrent BMP signaling maintenance and TGF- β signaling inhibition is a hallmark of natural resistance to muscle atrophy Laura Cussonneau,Christian Boyer,Emmanuelle Meugnier,Guillemette Gauquelin-Koch,Jon Arnemoet al. 18èmes Journées de la Société Française de Myologie, Nov 2021, Saint-Etienne, France Communication dans un congrès hal-04209791v1
What we can learn from the bear model: lessons from hibernation Etienne Lefai,Fabrice Bertile,Lydie Combaret European RFMF Metabomeeting, Metabolomics and Fluxomics Network, Metabolomics Profiling Forum, European regional metabolomics networks, Jan 2020, Toulouse, France Communication dans un congrès hal-04728774v1
Preservation of muscle mass : Lessons from hibernation Etienne Lefai,Cécile Coudy-Gandhilon,Lydie Combaret,Fabrice Bertile Journées Francophones de Nutrition, Société francaise de Nutrition, Nov 2020, On line, France Communication dans un congrès hal-04728748v1
Physical inactivity and preservation of muscle mass: Lessons from Hibernation Etienne Lefai Nobel Conference: Bioinspirational medicine – Using nature to unlock access to opportunities in health, Sep 2019, Stockholm, Sweden Communication dans un congrès hal-02285609v1
Integral lipidomic analysis of human skeletal muscle and visceral adipose tissue biopsy samples from lean, obese and type 2 diabetic individuals Ursula Loizides-Mangold,Stéphanie Chanon,M. Robert,Etienne Lefai,Charna Dibner 54. Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Oct 2018, berlin, Germany Communication dans un congrès hal-02733993v1
The study of hibernation in bears to improve human health Etienne Lefai 2018 Arctic Circle, Oct 2018, Reykjavik, Iceland Communication dans un congrès hal-01984299v1
Adipose stem cells contribute to inflammation and insulin resistance through both TH-17 polarisation and increased pro-inflammatory cytokine secretion A. Eljaafari,Maud Robert,Bilal Osta,Marwa Chehimi,Christine Durandet al. 49. Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), European Association for the Study of Diabetes (EASD). GBR., Sep 2013, Barcelone, Spain Communication dans un congrès hal-02741210v1

Poster de conférence (6)

Insights into the Transforming Growth Factor superfamily specific modulation: unravelling the impact of the winter-hibernating bear serum in primary human muscle cells Lydie Combaret,Chloé Richard,Guillaume Fourneaux,Alexandre Geffroy,Gwendal Cueffet al. Journée Scientifique CIR3, Oct 2024, Clermont- Ferrand, France Poster de conférence hal-04737549v1
Characterization of IL-6 and GDF15 expression during the transition from pre-anorexia to anorexia in the C26 tumor-bearing mouse model Ghita Chaouki,Laurent Parry,Laure Bindels,Céline Jousse,Isabelle Papetet al. SCWD 15th International Conference on Cachexia, Sarcopenia and Muscle Wasting 2022, Jun 2022, Lisbonne, Portugal Poster de conférence hal-04041599v1
Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear Laura Cussonneau,Emeric Dubois,Jon Arnemo,Christian Boyer,Christiane Devalet al. 9th Proteasome and Autophagy Congress, Oct 2021, Clermont-Ferrand, France Poster de conférence hal-04209822v1
Pretreatment with halofuginone attenuates adverse effects of acute inflammatory stress on mitochondrial alterations and mitophagy/biogenesis markers in liver Ghita Chaouki,Laurent Parry,Isabelle Papet,Céline Jousse,Etienne Lefaiet al. 9th proteasome and autophagy congress, 2021, Oct 2021, Clermont-Ferrand, France Poster de conférence hal-04845987v1
Genetic reprogramming involving a shift from TGF- β to BMP signaling for muscle mass maintenance in hibernating brown bear Lydie Combaret,Laura Cussonneau,Christian Boyer,Christiane Deval,Emmanuelle Meugnieret al. 23eme Journée de l'Ecole Doctorale Sciences de la Vie, Santé, Agronomie et Environnement, Oct 2020, Clermont-Ferrand, France Poster de conférence hal-04209939v1
Resolving transcription network from microarray data with constraint-based formal concept mining Jérémy Besson,Emmanuelle Meugnier,Jean-François Boulicaut,Etienne Lefai,Hubert Vidalet al. Ouvertes Biologie Informatique Mathématiques, JOBIM'05, Jul 2005, Lyon, France. pp.1-2, 2005 Poster de conférence hal-01614548v1

Brevet (1)

DI-RV-21-0111 (2021) : Dispositif pour le rinçage et/ou l’immersion en simultané de plusieurs lamelles en verre ou autres matériaux de dimensions standards. Cécile Coudy-Gandilhon,Fourneaux Guillaume,Etienne Lefai,Stéphane Portanguen,Pascal Tournayreet al. France, Patent n° : DI-RV-21-0111 (2021). 2021 Brevet hal-04818718v1