Etienne THEVENOT Responsable de l'équipe sciences des données métabolomiques pour la santé (Odiscé)

Identifiants chercheurs

IdHAL :

etienne-thevenot

ORCID :

0000-0003-1019-4577

IdRef :

089423585

VIAF :

208954192

ISNI :

0000000431972339

Présentation

Professional experience

Current professional status

Since 2020: Leader of the Metabolomics Data Sciences for Health team (CEA, Fundamental Research Division); CDI, full time devoted to research activities.

Since 2022: Co-leader of the multimodal integration workpackage from PROPSY (PEPR Exploratoire in precision psychiatry)

Since 2021: In charge of the multimodal data integration roadmap at CEA

Previous positions

2005-2019: Data scientist (CEA Tech); CDI, full time devoted to research activities.

2017-2021: Co-leader of the Integrative Bioinformatics task from IFB (French Institute of Bioinformatics)

2013-2017: Leader of the Bioinformatics workpackage from MetaboHUB (French infrastructure in metabolomics and ﬂuxomics)

Academic background

Habilitation à Diriger les Recherches en Informatique (2023). University Paris-Saclay. Ecole Doctorale “Sciences and Technologies of Information and Communication” (STIC; ED580).

Post-doctorate (2004-2005): Gene therapy and molecular imaging of neurodegenerative diseases (Neurodegenerative Diseases Laboratory, Molecular Imaging Research Center, MIRCen, CEA)

PhD in Molecular and Cellular Biology (2003). Pierre and Marie Curie University, Paris. Laboratoire de Génétique de la Neurotransmission et des Processus Neurodégénératifs (CNRS UMR 7091, Hôpital de la Pitié-Salpêtrière, Paris)

Diplôme d’Université (DU) in Higher Biomedical Education (2001). Paris-Sud University, Orsay.

Master of Molecular and Cellular Biology (1997). Pierre and Marie Curie University, Paris.

Master of Science and Executive Engineering (1996). MINES ParisTech graduate school, Paris.

Publications

Article dans une revue (28)

Nontargeted urine metabolomic analysis of acute intermittent porphyria reveals novel interactions between bile acids and heme metabolism: New promising biomarkers for the long‐term management of patients Thibaud Lefebvre,Thibaut Eguether,Etienne Thévenot,Antoine Poli,Emeline Chu-Vanet al. Journal of Inherited Metabolic Disease, 2025, 48 (1), ⟨10.1002/jimd.12809⟩ Article dans une revue hal-04863195v1
An untargeted data mining strategy for extracting chemical exposome signatures from LC-HRMS data: Application to meconium for early-life exposure assessment Dylan Saunier,Éric Venot,Blanche Guillon,Sylvain Dechaumet,Florence Castelliet al. Analytica Chimica Acta, 2025, 1379, pp.344751. ⟨10.1016/j.aca.2025.344751⟩ Article dans une revue hal-05447337v1
mineMS2: annotation of spectral libraries with exact fragmentation patterns Alexis Delabrière,Coline Gianfrotta,Sylvain Dechaumet,Annelaure Damont,Thaïs Hautbergueet al. Journal of Cheminformatics, 2025, 17, pp.111. ⟨10.1186/s13321-025-01051-y⟩ Article dans une revue hal-05406292v1
Workflow4Metabolomics (W4M): A User-Friendly Metabolomics Platform for Analysis of Mass Spectrometry and Nuclear Magnetic Resonance Data Cédric Delporte,Marie Tremblay-Franco,Yann Guitton,Cécile Canlet,Ralf J. M. Weberet al. Current Protocols, 2025, 5 (2), pp.e70095. ⟨10.1002/cpz1.70095⟩ Article dans une revue hal-04985097v1
Evaluation of SP3 for antibody-free quantification of tau in CSF mimic and brain by mass spectrometry Chloé Jacquemin,Nicolas Villain,Rita Azevedo,Susana Boluda,Etienne A Thévenotet al. European Journal of Mass Spectrometry, 2024, 30 (1), pp.65-75. ⟨10.1177/14690667231218912⟩ Article dans une revue hal-04735796v1
Scaling-up metabolomics: Current state and perspectives Ghina Hajjar,Millena Cristina Barros Santos,Justine Bertrand-Michel,Cécile Canlet,Florence A Castelliet al. Trends in Analytical Chemistry, 2023, 167 (20), pp.117225. ⟨10.1016/j.trac.2023.117225⟩ Article dans une revue (article de synthèse) hal-04188505v1
Assessment of an e-nose performance for the detection of COVID-19 specific biomarkers Christelle Ghazaly,Krystyna Biletska,Etienne Thevenot,Philippe Devillier,Emmanuel Nalineet al. Journal of Breath Research, 2023, 17 (2), pp.026006. ⟨10.1088/1752-7163/acb9b2⟩ Article dans une revue cea-04080762v1
ptairMS: real-time processing and analysis of PTR-TOF-MS data for biomarker discovery in exhaled breath Camille Roquencourt,Stanislas Grassin-Delyle,Etienne A Thévenot Bioinformatics, 2022, 38 (7), pp.1930-1937. ⟨10.1093/bioinformatics/btac031⟩ Article dans une revue cea-03598858v1
PeakForest: a multi-platform digital infrastructure for interoperable metabolite spectral data and metadata management Nils Paulhe,Cécile Canlet,Annelaure Damont,Lindsay Peyriga,Stéphanie Durandet al. Metabolomics, 2022, 18 (6), pp.40. ⟨10.1007/s11306-022-01899-3⟩ Article dans une revue hal-03695453v1
Multiplatform metabolomics for an integrative exploration of metabolic syndrome in older men Blandine Comte,Stéphanie Monnerie,Marion Brandolini-Bunlon,Cécile Canlet,Florence Castelliet al. EBioMedicine, 2021, 69, ⟨10.1016/j.ebiom.2021.103440⟩ Article dans une revue hal-03283772v1
ProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis Alyssa Imbert,Magali Rompais,Mohammed Selloum,Florence Castelli,Emmanuelle Mouton-Barbosaet al. Scientific Data , 2021, 8 (1), pp.311. ⟨10.1038/s41597-021-01095-3⟩ Article dans une revue pasteur-03453736v1
Bariatric Surgery Improves the Atherogenic Profile of Circulating Methylarginines in Obese Patients: Results from a Pilot Study Julie Poirier,Chloé Cloteau,Audrey Aguesse,Xavier Billot,Etienne Thévenotet al. Metabolites, 2021, 11 (11), pp.759. ⟨10.3390/metabo11110759⟩ Article dans une revue hal-03653351v1
Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study Stanislas Grassin-Delyle,Camille Roquencourt,Pierre Moine,Gabriel Saffroy,Stanislas Carnet al. EBioMedicine, 2021, 63, pp.103154. ⟨10.1016/j.ebiom.2020.103154⟩ Article dans une revue cea-03086093v1
Metabolic reprograming of LPS-stimulated human lung macrophages involves tryptophan metabolism and the aspartate-arginosuccinate shunt Fanta Fall,Elodie Lamy,Marion Brollo,Emmanuel Naline,Natacha Lenuzzaet al. PLoS ONE, 2020, 15 (4), pp.e0230813. ⟨10.1371/journal.pone.0230813⟩ Article dans une revue inserm-02543848v1
Differential effects of post-weaning diet and maternal obesity on mouse liver and brain metabolomes Sofiane Safi-Stibler,Mélanie Jouin,Etienne A Thévenot,Luc Jouneau,Alexandre Seyeret al. Nutrients, 2020, 12 (6), pp.1572. ⟨10.3390/nu12061572⟩ Article dans une revue hal-02867469v1
Interoperable and scalable data analysis with microservices: applications in metabolomics Payam Emami Khoonsari,Pablo Moreno,Sven Bergmann,Joachim Burman,Marco Capucciniet al. Bioinformatics, 2019, 35 (19), pp.3752-3760. ⟨10.1093/bioinformatics/btz160⟩ Article dans une revue cea-04562419v1
A split-range acquisition method for the non-targeted metabolomic profiling of human plasma with hydrophilic interaction chromatography - high-resolution mass spectrometry Fanta Fall,Natacha Lenuzza,Elodie Lamy,Marion Brollo,Emmanuel Nalineet al. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2019, 1128, pp.121780 -. ⟨10.1016/j.jchromb.2019.121780⟩ Article dans une revue hal-03488294v1
PhenoMeNal: processing and analysis of metabolomics data in the cloud Kristian Peters,James Bradbury,Sven Bergmann,Marco Capuccini,Marta Cascanteet al. GigaScience, 2019, 8 (2), pp.giy149. ⟨10.1093/gigascience/giy149⟩ Article dans une revue hal-02627233v1
Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS Florence Souard,Cédric Delporte,Piet Stoffelen,Etienne Thévenot,Nausicaa Noretet al. Food Chemistry, 2018, 245, pp.603 - 612. ⟨10.1016/j.foodchem.2017.10.022⟩ Article dans une revue cea-01765677v1
proFIA: A data preprocessing workflow for Flow Injection Analysis coupled to High-Resolution Mass Spectrometry Alexis Delabrière,Ulli A Hohenester,Benoit A Colsch,Christophe A Junot,François A Fenailleet al. Bioinformatics, 2017, 33 (23), pp.3767-3775. ⟨10.1093/bioinformatics/btx458⟩ Article dans une revue hal-01574347v1
The future of metabolomics in ELIXIR M. van Rijswijk,C. Beirnaert,C. Caron,M. Cascante,V. Dominguezet al. F1000Research, 2017, 6 (Version 2), ⟨10.12688/f1000research.12342.2⟩ Article dans une revue hal-01630635v1
Create, run, share, publish, and reference your LC-MS, FIA-MS, GC-MS, and NMR data analysis workflows with the Workflow4Metabolomics 3.0 Galaxy online infrastructure for metabolomics Yann Guitton,Marie Tremblay-Franco,Gildas A Le Corguillé,Jean-Francois Martin,Mélanie Pétéraet al. International Journal of Biochemistry and Cell Biology, 2017, 93, pp.89-101. ⟨10.1016/j.biocel.2017.07.002⟩ Article dans une revue hal-01574351v1
Safety and pharmacokinetics of the CIME combination of drugs and their metabolites after a single oral dosing in healthy volunteers Natacha Lenuzza,Xavier Duval,Grégory Nicolas,Etienne Thévenot,Sylvie Jobet al. European journal of drug metabolism and pharmacokinetics, 2016, 41 (2), pp.125-138. ⟨10.1007/s13318-014-0239-0⟩ Article dans une revue hal-01868750v1
biosigner: A New Method for the Discovery of Significant Molecular Signatures from Omics Data Philippe Rinaudo,Samia Boudah,Christophe Junot,Etienne Thévenot Frontiers in Molecular Biosciences, 2016, 3, ⟨10.3389/fmolb.2016.00026⟩ Article dans une revue hal-01869335v1
Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical Analyses Etienne Thévenot,Aurélie Roux,Ying Xu,Eric Ezan,Christophe Junot Journal of Proteome Research, 2015, 14 (8), pp.3322 - 3335. ⟨10.1021/acs.jproteome.5b00354⟩ Article dans une revue cea-01865435v1
Workflow4Metabolomics: A collaborative research infrastructure for computational metabolomics Franck Giacomoni,Gildas Le Corguillé,Misharl Monsoor,Marion Landi,Pierre Pericardet al. Bioinformatics, 2015, 31 (9), pp.1493-1495. ⟨10.1093/bioinformatics/btu813⟩ Article dans une revue hal-01123263v1
Impact of collection conditions on the metabolite content of human urine samples as analyzed by liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy Aurélie Roux,Etienne Thévenot,François Seguin,Marie-Françoise Olivier,Christophe Junot Metabolomics, 2015, 11 (5), pp.1095 - 1105. ⟨10.1007/s11306-014-0764-5⟩ Article dans une revue hal-01864965v1
Is RE1/NRSE a Common cis -Regulatory Sequence for ChAT and VAChT Genes? Stephanie de Gois,Leïla Houhou,Yoshio Oda,Marilys Corbex,Fabrice Pajaket al. Journal of Biological Chemistry, 2000, 275 (47), pp.36683-36690. ⟨10.1074/jbc.M006895200⟩ Article dans une revue hal-02920246v1

Poster de conférence (21)

ProMetIS 2.0: proteomics and metabolomics data analysis and integration, applied to the characterization of the Lat and Mx2 knock-out phenotypes Oneeb Nasir,Alyssa Imbert,Sylvain Dechaumet,Pierrick Roger,Thomas Burgeret al. Journées Ouvertes en Biologie, Informatique, et Mathématiques (JOBIM 2024), Jun 2024, Toulouse, France. 2007 Poster de conférence hal-05035118v1
Automatic search for chemical exposure markers in LC-HRMS metabolomic data Dylan Saunier,Eric Venot,Sylvain Dechaumet,N Behkti,Blanche Guillonet al. 15èmes Journées Scientifiques du Réseau Francophone de Métabolomique et Fluxomique, May 2023, Perpignan, France Poster de conférence hal-04644047v1
Influence of FUT2/FUT3 polymorphism on human breastmilk oligosaccharide composition in the EDEN mother-child cohort Eric Venot,Sylvain Dechaumet,Blanche Guillon,Mikaïl Berdi,Sophie Choletet al. Journées scientifiques du Réseau Francophone de Métabolomique et Fluxomique, May 2023, Perpignan, France Poster de conférence hal-04351464v1
Technological developments and opportunities with Workflow4Metabolomics Mélanie Pétéra,Yann Guitton,Charlotte Joly,Florence Souard,Etienne A Thévenotet al. ISMB/ECCB 2023: The 31st Annual Intelligent Systems For Molecular Biology and the 22nd Annual European Conference on Computational Biology, Jul 2023, Lyon, France Poster de conférence hal-04185176v1
Optimization of E-nose technology for detecting nonanal: a COVID-19 biomarker in exhaled breath Christelle Ghazaly,Krystyna Biletska,Etienne Thevenot,Philippe Devillier,Emmanuel Nalineet al. MNE-ES 2022 - 48th international conference on Micro and Nano Engineering - Eurosensors, Sep 2022, Leuven, Belgium. 2022 Poster de conférence cea-04081230v1
Development of an automated bioinformatic workflow to assess oligosaccharide composition of early breast milk samples from LC-HRMS data Eric Venot,Sylvain Dechaumet,Blanche Guillon,Mikaïl Berdi,Ghita Tajeddineet al. Journées scientifiques du Réseau Francophone de Fluxomique et de Métabolomique, Nov 2021, AUSSOIS, France Poster de conférence hal-04351512v1
Integrated Multi-omics of early breast milk constituents Camilo Broc,Blanche Guillon,Mikaïl Berdi,Eric Venot,Benoit Colschet al. Intelligent Systems for Molecular Biology/European Conference on computaional biology, Jul 2021, Virtuel, France Poster de conférence hal-03739277v1
Development and characterization of electronic noses for the rapid detection of COVID-19 in exhaled breath Christelle Ghazaly,Krystyna Biletska,Etienne A Thévenot,Philippe Devillier,Emmanuel Nalineet al. 10th Franco-Spanish Workshop CMC2-IBERNAM, Nov 2021, Arcachon, France. Poster de conférence cea-03713273v1
Processing and analysis of PTR-TOF mass spectrometry data for biomarker discovery in exhaled breath Camille Roquencourt,Stanislas Grassin Delyle,Etienne A Thévenot ASMS 2021 - 69th ASMS Conference on Mass Spectrometry and Allied Topics, Oct 2021, Philadelphie, United States. 2021 Poster de conférence cea-04933748v1
INPUT OF DEEP PHENOTYPING IN THE METABOLIC SYNDROME STRATIFICATION Stéphanie Monnerie,Mélanie Pétéra,Cécile Canlet,Florence Castelli,Benoit Colschet al. European RFMF Metabomeeting 2020, Jan 2020, Toulouse, France. , 262 p., 2020, Oral and Poster Abstracts European RMF Metabomeeting 2020 Poster de conférence hal-02505908v1
Pre-conceptional maternal metabolic status influences hepatic metabolome in male offspring Sofiane Safi-Stibler,Delphine Rousseau-Ralliard,Mélanie Jouin,Luc Jouneau,Claudine Junienet al. World congress developmental origins of health and disease (DOHAD) 2019, Oct 2019, Melbourne, Australia. , 2019 Poster de conférence hal-02408206v1
From Molecular Profiling to Precision Medicine in Metabolic Syndrome Blandine Comte,Stéphanie Monnerie,Marion Brandolini-Bunlon,Cécile Canlet,Florence Castelliet al. 15th Annual Conference of the Metabolomics Society (Metabolomics 2019), Jun 2019, La Haye, Netherlands. 300 p., 2019 Poster de conférence hal-02293580v1
Optimized selection process to identify a metabolic syndrome metabolomic/lipidomic signature in older adults of the NuAge cohort Natacha Lenuzza,Etienne Thévenot,Mélanie Pétéra,Stéphanie Monnerie,José A Moraiset al. 13. Congress of the European Union Geriatric Medicine Society (EUGMS), Sep 2017, Nice, France. European Geriatric Medicine, 8, 276 p., 2017, Abstracts of the 13th International Congress of the European Union Geriatric Medicine Society –Developing Preventive Actions in Geriatrics Poster de conférence hal-02736369v1
PeakForest: a spectral database and its toolbox, dedicated to the Metabolomics’ community Nils Paulhe,Christophe Duperier,Marie Lefebvre,Pierrick Roger-Mele,Christophe Junotet al. 12. annual conference of the Metabolomics Society, Jun 2016, Dublin, United Kingdom. 2016 Poster de conférence hal-02744357v1
Enrichissement de la base de données spectrale peakforest en LC-MS Sylvain Emery,Bernard Lyan,Charlotte Joly,Nils Paulhe,Franck Giacomoniet al. 10. journées scientifiques du Réseau Francophone de Métabolomique et Fluxomique, May 2016, Montpellier, France. 158 p., 2016, Livret des résumés 10JS RFMF Poster de conférence hal-01594987v1
PeakForest: a spectral reference database made from metabolomic experts for metabolomic analyses Nils Paulhe,Pierrick Roger,Marie-Françoise Olivier,Marie Lefebvre,Christophe Duperieret al. 9. Journées scientifiques du RFMF, Jun 2015, Lille, France. 2015 Poster de conférence hal-02742964v1
New tools and workflows on W4M, the Galaxy metabolomic infrastructure Marion Landi,Claire Lopez,Marie Tremblay-Franco,Cécile Canlet,Yann Guittonet al. 9e Journées scientifiques du RFMF, Jun 2015, Lille, France. , 2015 Poster de conférence hal-02743697v1
Workﬂow4Metabolomics: A collaborative research infrastructure for computational metabolomics Mélanie Pétéra,Gildas Le Corguille,Marion Landi,Misharl Monsoor,Marie Tremblay-Francoet al. JOBIM 2015 (16e édition des Journées Ouvertes en Biologie, Informatique et Mathématiques ), Jul 2015, Clermont-Ferrand, France. , 2015, JOBIM (16e édition des Journées Ouvertes en Biologie, Informatique et Mathématiques ). ⟨10.1093/bioinformatics/btu813⟩ Poster de conférence hal-01214152v1
Spectral Database: from data model to web interface Nils Paulhe,Christophe Duperier,Daniel Jacob,Etienne Thévenot,Jean-Francois Martinet al. 8. Journées Scientifiques du Réseau Français de Métabolomique et Fluxomique RFMF, May 2014, Lyon, France. 2014 Poster de conférence hal-02742064v1
Factory and Libraries for Automatic Metabolomic Exploration : F.L.A.M.E Marion Landi,Mélanie Pétéra,Mishari Monsoor,Gildas Le Corguillé,Christophe Duperieret al. 8. Journées Scientifiques du Réseau Français de Métabolomique et Fluxomique RFMF, May 2014, Lyon, France. 2014 Poster de conférence hal-02743239v1
Mass Spectrometry Imaging visualization tools developed during the Computis European project Marie-France Robbe,Etienne A Thévenot,Markus Stoeckli,Alfons Hester,Andreas Roemppet al. Congrès français de spectrométrie de masse et d'analyse protéomique (SMAP 2011), Sep 2011, Avignon, France. Book of abstracts of SMAP 2011 Poster de conférence cea-03086461v1

Communication dans un congrès (5)

Non-negative matrix factorization of SWATH DIA data improves global metabolite identification Diana Karaki,Sylvain Dechaumet,Annelaure Damont,Benoit Colsch,François Fenailleet al. EUSIPCO 2024 - 32nd European Signal Processing Conference, Aug 2024, Lyon, France Communication dans un congrès hal-04802338v1
Workflow4Metabolomics: an international computing infrastructure for Metabolomics Mélanie Pétéra,Romain Dallet,Christophe Dupérier,Franck Giacomoni,Yann Guittonet al. 2019 Galaxy Community Conference (GCC2019), Jul 2019, Freibourg, Germany Communication dans un congrès hal-02264362v1
Le statut métabolique maternal préconceptionnel influence le métabolisme hépatique des descendants mâles Sofiane Safi-Stibler,Delphine Rousseau-Ralliard,Luc Jouneau,Mélanie Jouin,Claudine Junienet al. 4. Congrès de la SF-Dohad, Société Francophone-DOHaD. FRA., Nov 2018, Grenoble, France. pp.120 Communication dans un congrès hal-02736388v1
PeakForest: a spectral reference database made from metabolomic experts for metabolomic analyses Nils Paulhe,Pierrick Roger,Marie-Françoise Olivier,Marie Lefebvre,Christophe Duperieret al. 9. Journées scientifiques du RFMF, Réseau Francophone de Métabolomique et Fluxomique (RFMF). FRA., Jun 2015, Lille, France Communication dans un congrès hal-02742965v1
MetaboHUB and RFMF : two tools at the service of metabolomics and fluxomics in France Dominique Rolin,Floriant Bellvert,Justine Bertrand-Michel,Cécile Canlet,Richard Coleet al. MERLION Metabolomics Workshop Singapore 2014, Nov 2014, Singapore, Singapore Communication dans un congrès hal-02798242v1