Ewen Lescop

Identifiants chercheurs

IdHAL :

ewen-lescop

ORCID :

0000-0002-2623-9365

IdRef :

078210895

Présentation

Nuclear Magnetic Resonance (NMR) spectroscopy provides a wealth of information about the structure and dynamics of biomolecules in solution as well as of their complexes. As such, it highly contributes to our understanding of the molecular mechanisms that underly life. Such knowledge is fundamental not only for the general quest for a better understanding of nature but is also required for rational approaches in health or agronomy industry.

My research interests lie in the development of NMR methods, in particular to speed up NMR data collection and the application of NMR to understand the role of interdomain dynamics in the catalytic cycle of the human CPR, the role of heme orientation in the function of the hexacoordinated human neuroglobin and the structural and dynamics study of microcins and the TCTP cancer drug. More recently I started a research program about protein/lipid interactions with biomembrane with a new and original approach using high-pressure NMR.

Publications

Pré-publication, Document de travail (2)

Cytoplasmic FKBP7 reflux controls NFE2L1 levels as an adaptive response to chemotherapy in prostate cancer cells Luce Dreno,Farès Ousalem,Besimé Celik,Giuseppina Claps,Nader Al Nakouziet al. 2026 Pré-publication, Document de travail hal-05525667v1
Structural transitions in TCTP tumor protein upon Mcl-1 binding Florian Malard,Christina Sizun,Aurélien Thureau,Ludovic Carlier,Ewen Lescop 2022 Pré-publication, Document de travail hal-03864191v1

Article dans une revue (62)

Allosteric coupling between a lipid bilayer and a membrane protein Clarisse Fourel,Yanna Gautier,Alexandre Pozza,François Giraud,Elodie Pointet al. Biophysical Journal, 2025, ⟨10.1016/j.bpj.2025.06.033⟩ Article dans une revue hal-04954807v1
Structural transitions in TCTP tumor protein upon binding to the anti-apoptotic protein family member Mcl-1 Florian Malard,Christina Sizun,Aurélien Thureau,Ludovic Carlier,Ewen Lescop Journal of Biological Chemistry, 2023, 299 (7), pp.104830. ⟨10.1016/j.jbc.2023.104830⟩ Article dans une revue hal-04208651v1
Revisiting the molecular interactions between the tumor protein TCTP and the drugs sertraline/thioridazine. Florian Malard,Eric Jacquet,Naima Nhiri,Christina Sizun,Amélie Chabrieret al. ChemMedChem, 2022, 17 (1), pp.e202100528. ⟨10.1002/cmdc.202100528⟩ Article dans une revue hal-03370569v2
Investigation of the Low-Populated Excited States of the HIV-1 Nucleocapsid Domain Assia Mouhand,Loussiné Zargarian,Anissa Belfetmi,Marjorie Catala,Marco Pasiet al. Viruses, 2022, 14 (3), pp.632. ⟨10.3390/v14030632⟩ Article dans une revue hal-03671481v1
EpyNN: Educational python for Neural Networks Florian Malard,Laura Danner,Emilie Rouzies,Jesse Meyer,Ewen Lescopet al. SoftwareX, 2022, 19, pp.101140. ⟨10.1016/j.softx.2022.101140⟩ Article dans une revue hal-03795656v1
Exploration of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure Alexandre Pozza,François Giraud,Quentin Cece,Marina Casiraghi,Elodie Pointet al. Nature Communications, 2022, 13 (1), pp.1780. ⟨10.1038/s41467-022-29410-5⟩ Article dans une revue hal-03665500v1
Drimane derivatives as the first examples of covalent BH3-mimetics that target MCL-1 Florian Daressy,Florian Malard,Line Seguy,Vincent Guérineau,Cécile Apelet al. ChemMedChem, 2021, 16 (11), pp.1789-1798. ⟨10.1002/cmdc.202100011⟩ Article dans une revue hal-03279424v1
Structural and dynamic characterization of the C-terminal tail of ErbB2: disordered but not random L. Pinet,Y.-H. Wang,C. Deville,E. Lescop,F. Guerlesquinet al. Biophysical Journal, 2021, 120 (10), pp.1869-1882. ⟨10.1016/j.bpj.2021.03.005⟩ Article dans une revue hal-03095358v2
Nuclear Magnetic Resonance Spectroscopy: A Multifaceted Toolbox to Probe Structure, Dynamics, Interactions, and Real-Time In Situ Release Kinetics in Peptide-Liposome Formulations Camille Doyen,Eric Larquet,Pierre-Damien Coureux,Oriane Frances,Frédéric Hermanet al. Molecular Pharmaceutics, 2021, 18 (7), pp.2521-2539. ⟨10.1021/acs.molpharmaceut.1c00037⟩ Article dans une revue hal-03301899v1
The unusual structure of the PiggyMac cysteine-rich domain reveals zinc finger diversity in PiggyBac-related transposases Marc Guérineau,Luiza Bessa,Séverine Moriau,Ewen Lescop,François Bontemset al. Mobile DNA, 2021, 12 (1), ⟨10.1186/s13100-021-00240-4⟩ Article dans une revue hal-03302627v1
NMR Characterization of the Influence of Zinc(II) Ions on the Structural and Dynamic Behavior of the New Delhi Metallo-β-Lactamase-1 and on the Binding with Flavonols as Inhibitors Gwladys Rivière,Saoussen Oueslati,Maud Gayral,Jean-Bernard Créchet,Naïma Nhiriet al. ACS Omega, 2020, 5 (18), pp.10466-10480. ⟨10.1021/acsomega.0c00590⟩ Article dans une revue hal-02604220v1
Natural Chlordecone Degradation Revealed by Numerous Transformation Products Characterized in Key French West Indies Environmental Compartments Marion L. Chevallier,Oriane Della-Negra,Sébastien Chaussonnerie,Agnès Barbance,Delphine Museletet al. Environmental Science and Technology, 2019, 53 (11), pp.6133-6143. ⟨10.1021/acs.est.8b06305⟩ Article dans une revue hal-02309073v1
Ubiquitin is double-phosphorylated by PINK1 for enhanced pH-sensitivity of conformational switch Shang-Xiang Ye,Zhou Gong,Ju Yang,Yu-Xin An,Zhu Liuet al. Protein and Cell, 2019, ⟨10.1007/s13238-019-0644-x⟩ Article dans une revue hal-02309074v1
Impact of A90P, F106L and H64V mutations on neuroglobin stability and ligand binding kinetics Eric André,Valérie Derrien,Pierre Sebban,Nadine Assrir,Ewen Lescopet al. Journal of Biological Inorganic Chemistry, 2019, 24 (1), pp.39-52. ⟨10.1007/s00775-018-1625-x⟩ Article dans une revue hal-02114795v1
Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome Christelle C. Arrondel,Sophia Missoury,Rozemarijn Snoek,Julie Patat,Giulia Menaraet al. Nature Communications, 2019, 10 (1), pp.3967. ⟨10.1038/s41467-019-11951-x⟩ Article dans une revue inserm-02322309v1
YB-1, an abundant core mRNA-binding protein, has the capacity to form an RNA nucleoprotein filament: a structural analysis Dmitry Kretov,Marie-Jeanne Clément,Guillaume Lambert,Dominique Durand,Dmitry Lyabinet al. Nucleic Acids Research, 2019, 47 (6), pp.3127-3141. ⟨10.1093/nar/gky1303⟩ Article dans une revue hal-02114790v1
Evidence of Cis/Trans-Isomerization at Pro7/Pro16 in the Lasso Peptide Microcin J25 Kévin Jeanne Dit Fouque,Julian D Hegemann,Séverine Zirah,Sylvie Rebuffat,Ewen Lescopet al. Journal of The American Society for Mass Spectrometry, 2019, 30 (6), pp.1038-1045. ⟨10.1007/s13361-019-02134-5⟩ Article dans une revue hal-02114349v1
The H 2 O 2 -Resistant Fe–S Redox Switch MitoNEET Acts as a pH Sensor To Repair Stress-Damaged Fe–S Protein Cécile Mons,Thomas Botzanowski,Anton Nikolaev,Petra Hellwig,Sarah Cianféraniet al. Biochemistry, 2018, 57 (38), pp.5616-5628. ⟨10.1021/acs.biochem.8b00777⟩ Article dans une revue hal-02129718v1
Sequence-specific DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase Nelly Morellet,Xianghong Li,Silke Wieninger,Jennifer Taylor,Julien Bischerouret al. Nucleic Acids Research, 2018, 46 (5), pp.2660-2677. ⟨10.1093/nar/gky044⟩ Article dans une revue hal-02114800v1
Structural Basis for Natural Product Selection and Export by Bacterial ABC Transporters Maria Romano,Giuliana Fusco,Hassanul G Choudhury,Shahid Mehmood,Carol V Robinsonet al. ACS Chemical Biology, 2018, 13 (6), pp.1598 - 1609. ⟨10.1021/acschembio.8b00226⟩ Article dans une revue hal-03301757v1
Illuminating the Energy Landscape of GPCRs: The Key Contribution of Solution-State NMR Associated with Escherichia coli as an Expression Host Marina Casiraghi,Marjorie Damian,Ewen Lescop,Jean-Louis Banères,Laurent J Catoire Biochemistry, 2018, 57 (16), pp.2297-2307. ⟨10.1021/acs.biochem.8b00035⟩ Article dans une revue hal-03011579v1
Conformational Ensemble and Biological Role of the TCTP Intrinsically Disordered Region: Influence of Calcium and Phosphorylation Florian Malard,Nadine Assrir,Mouad Alami,Samir Messaoudi,Ewen Lescopet al. Journal of Molecular Biology, 2018, 430 (11), pp.1621-1639. ⟨10.1016/j.jmb.2018.04.024⟩ Article dans une revue hal-02114798v1
1H, 13C and 15N assignments of the C-terminal intrinsically disordered cytosolic fragment of the receptor tyrosine kinase ErbB2 Yinghui Wang,Louise Pinet,Nadine Assrir,Latifa Elantak,Francoise Guerlesquinet al. Biomolecular NMR Assignments, 2017, 12 (1), pp.23 - 26. ⟨10.1007/s12104-017-9773-4⟩ Article dans une revue hal-01791552v1
New insights into structural disorder in human respiratory syncytial virus phosphoprotein and implications for binding of protein partners Nelson Pereira,Christophe Cardone,Safa Lassoued,Marie Galloux,Jenna Fixet al. Journal of Biological Chemistry, 2017, 292 (6), pp.2120-2131. ⟨10.1074/jbc.M116.765958⟩ Article dans une revue hal-01605660v1
Combined Biochemical, Biophysical, and Cellular Methods to Study Fe–S Cluster Transfer and Cytosolic Aconitase Repair by MitoNEET Cécile Mons,Ioana Ferecatu,Sylvie Riquier,Ewen Lescop,Cécile Boutonet al. Methods in Enzymology, 2017, 595, pp.83-106. ⟨10.1016/bs.mie.2017.07.010⟩ Article dans une revue hal-01873518v1
Redox Control of the Human Iron-Sulfur Repair Protein MitoNEET Activity via Its Iron-Sulfur Cluster Marie-Pierre Golinelli-Cohen,Ewen Lescop,Cécile Mons,Sergio Gonçalves,Martin Clémanceyet al. Journal of Biological Chemistry, 2016, 291 (14), pp.7583 - 7593. ⟨10.1074/jbc.m115.711218⟩ Article dans une revue hal-01873511v1
Small fluorescence-activating and absorption-shifting tag for tunable protein imaging in vivo Marie-Aude Plamont,Emmanuelle Billon-Denis,Sylvie Maurin,Carole Gauron,Frederico M. Pimentaet al. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (3), pp.497-502. ⟨10.1073/pnas.1513094113⟩ Article dans une revue hal-01259909v1
Functional Modulation of a G Protein-Coupled Receptor Conformational Landscape in a Lipid Bilayer Marina Casiraghi,Marjorie Damian,Ewen Lescop,Elodie Point,Karine Moncoqet al. Journal of the American Chemical Society, 2016, 138 (35), pp.11170-11175. ⟨10.1021/jacs.6b04432⟩ Article dans une revue hal-02114802v1
Intramolecular Pd-Catalyzed Arylation of 1-Amidosugars: A New Route to N -Glycosyl Quinolin-2-ones Thi Thanh Huyen Luong,Jean-Daniel Brion,Ewen Lescop,Mouad Alami,Samir Messaoudi Organic Letters, 2016, 18 (9), pp.2126-2129. ⟨10.1021/acs.orglett.6b00752⟩ Article dans une revue hal-02118684v1
Initial Molecular Recognition Steps of McjA Precursor during Microcin J25 Lasso Peptide Maturation Nadine Assrir,Anna Pavelkova,Régine Dazzoni,Rémi Ducasse,Nelly Morelletet al. ChemBioChem, 2016, 17 (19), pp.1851-1858. ⟨10.1002/cbic.201600306⟩ Article dans une revue istex hal-02118696v1
Characterization of Sviceucin from Streptomyces Provides Insight into Enzyme Exchangeability and Disulfide Bond Formation in Lasso Peptides. Yanyan Li,Rémi Ducasse,Séverine Zirah,Alain Blond,Christophe Goulardet al. ACS Chemical Biology, 2015, 10 (11), pp.2641-9. ⟨10.1021/acschembio.5b00584⟩ Article dans une revue hal-01430638v1
A Well-Balanced Preexisting Equilibrium Governs Electron Flux Efficiency of a Multidomain Diflavin Reductase Oriane Frances,Fataneh Fatemi,Denis Pompon,Eric Guittet,Christina Sizunet al. Biophysical Journal, 2015, 108 (6), pp.1527-1536. ⟨10.1016/j.bpj.2015.01.032⟩ Article dans une revue hal-01142871v1
Mapping the UDP-N-acetylglucosamine regulatory site of human glucosamine-6P synthase by saturation-transfer difference NMR and site-directed mutagenesis. Nadine Assrir,Celine Richez,Philippe Durand,Eric Guittet,Bernard Badetet al. Biochimie, 2014, 97, pp.39-48. ⟨10.1016/j.biochi.2013.09.011⟩ Article dans une revue istex hal-00912794v1
The Diabetes Drug Target MitoNEET Governs a Novel Trafficking Pathway to Rebuild an Fe-S Cluster into Cytosolic Aconitase/Iron Regulatory Protein 1 Ioana Ferecatu,Sergio Gonçalves,Marie-Pierre Golinelli-Cohen,Martin Clémancey,Alain Martelliet al. Journal of Biological Chemistry, 2014, 289 (41), pp.28070 - 28086. ⟨10.1074/jbc.m114.548438⟩ Article dans une revue hal-01873509v1
Heme orientation modulates histidine dissociation and ligand binding kinetics in the hexacoordinated human neuroglobin. Anthony Bocahut,Valérie Derrien,Sophie Bernad,Pierre Sebban,Sophie Sacquin-Moraet al. Journal of Biological Inorganic Chemistry, 2013, 18 (1), pp.111-22. ⟨10.1007/s00775-012-0956-2⟩ Article dans une revue hal-00783539v1
Heme orientation modulates histidine dissociation and ligand binding kinetics in the hexacoordinated human neuroglobin A Bocahut,V Derrien,S Bernad,P. Sebban,S Sacquin-Moraet al. Journal of Biological Inorganic Chemistry, 2013, 18 (1) Article dans une revue hal-01326196v1
Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides. Amandine Altmayer-Henzien,Valérie Declerck,David J Aitken,Ewen Lescop,Denis Merletet al. Organic & Biomolecular Chemistry, 2013, 11 (43), pp.7611-5. ⟨10.1039/c3ob41876f⟩ Article dans une revue hal-00912800v1
Optimization of the production of gurmarin, a sweet-taste-suppressing protein, secreted by the methylotrophic yeast Pichia pastoris. Maud Sigoillot,Anne Brockhoff,Ewen Lescop,Nicolas Poirier,Wolfgang Meyerhofet al. Applied Microbiology and Biotechnology, 2012, 96 (5), pp.1253-63. ⟨10.1007/s00253-012-3897-3⟩ Article dans une revue istex hal-00763833v1
Sequence determinants governing the topology and biological activity of a lasso Peptide, microcin J25. Rémi Ducasse,Kok-Phen Yan,Christophe Goulard,Alain Blond,Yanyan Liet al. ChemBioChem, 2012, 13 (3), pp.371-80. ⟨10.1002/cbic.201100702⟩ Article dans une revue istex hal-00678535v1
The closed and compact domain organization of the 70-kDa human cytochrome P450 reductase in its oxidized state as revealed by NMR. Bruno Vincent,Nelly Morellet,Fataneh Fatemi,Louise Aigrain,Gilles Truanet al. Journal of Molecular Biology, 2012, 420 (4-5), pp.296-309. ⟨10.1016/j.jmb.2012.03.022⟩ Article dans une revue istex hal-00733233v1
Dynamic control of electron transfers in diflavin reductases. Louise Aigrain,Fataneh Fatemi,Oriane Frances,Ewen Lescop,Gilles Truan International Journal of Molecular Sciences, 2012, 13 (11), pp.15012-41. ⟨10.3390/ijms131115012⟩ Article dans une revue hal-00798113v1
Fast protein backbone NMR resonance assignment using the BATCH strategy. Bernhard Brutscher,Ewen Lescop Methods in Molecular Biology, 2012, 831, pp.407-28. ⟨10.1007/978-1-61779-480-3_21⟩ Article dans une revue hal-00798115v1
Rapid measurement of residual dipolar couplings for fast fold elucidation of proteins. Rodolfo M Rasia,Ewen Lescop,Javier F Palatnik,Jérôme Boisbouvier,Bernhard Brutscher Journal of Biomolecular NMR, 2011, 51 (3), pp.369-78. ⟨10.1007/s10858-011-9567-4⟩ Article dans une revue istex hal-00689143v1
La résonance magnétique nucléaire au service de la biologie structurale N. Birlirakis,F. Bontems,E. Guittet,J. L. Leroy,E. Lescopet al. L'Actualité Chimique, 2011, 353-354, pp.100-109 Article dans une revue hal-00759164v1
Structure, dynamics, and kinetics of weak protein-protein complexes from NMR spin relaxation measurements of titrated solutions. Loïc Salmon,José-Luis Ortega Roldan,Ewen Lescop,Antoine Licinio,Nico van Nulandet al. Angewandte Chemie International Edition, 2011, 50 (16), pp.3755-3759. ⟨10.1002/anie.201100310⟩ Article dans une revue istex hal-00605370v1
Guidelines for the use of band-selective radiofrequency pulses in hetero-nuclear NMR: Example of longitudinal-relaxation-enhanced BEST-type 1H­15N correlation experiments E. Lescop,T. Kern,B. Brutscher Journal of Magnetic Resonance, 2010, 203 (1), pp.190-198. ⟨10.1016/j.jmr.2009.12.001⟩ Article dans une revue istex hal-00464636v1
Dynamics of the Conformational Transitions in the Assembling of the Michaelis Complex of a Bisubstrate Enzyme: A 15 N Relaxation Study of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase † Ewen Lescop,Zhenwei Lu,Qin Liu,Huimin Xu,Guangyu Liet al. Biochemistry, 2009, 48 (2), pp.302-312. ⟨10.1021/bi8016262⟩ Article dans une revue hal-02114811v1
Structural basis of the broad specificity of a General Odorant-Binding Protein from honeybee. Ewen Lescop,Loïc Briand,Jean-Claude Pernollet,Eric Guittet Biochemistry, 2009, 48 (11), pp.2431-2441. ⟨10.1021/bi802300k⟩ Article dans une revue hal-00375337v1
Highly automated protein backbone resonance assignment within a few hours: the &quot;BATCH&quot; strategy and software package. Ewen Lescop,Bernhard Brutscher Journal of Biomolecular NMR, 2009, 44 (1), pp.43-57. ⟨10.1007/s10858-009-9314-2⟩ Article dans une revue istex hal-00385027v1
Hadamard Amino-Acid-Type Edited NMR Experiment for Fast Protein Resonance Assignment Ewen Lescop,Rodolfo Rasia,Bernhard Brutscher Journal of the American Chemical Society, 2008, 130 (15), pp.5014-5015. ⟨10.1021/ja800914h⟩ Article dans une revue istex hal-02114814v1
Quantitative conformational analysis of partially folded proteins from residual dipolar couplings: application to the molecular recognition element of Sendai virus nucleoprotein. Malene Ringkjøbing Jensen,Klaartje Houben,Ewen Lescop,Laurence Blanchard,Rob W H Ruigroket al. Journal of the American Chemical Society, 2008, 130 (25), pp.8055-61. ⟨10.1021/ja801332d⟩ Article dans une revue istex hal-00337329v1
Hyperdimensional Protein NMR Spectroscopy in Peptide-Sequence Space Ewen Lescop,Bernhard Brutscher Journal of the American Chemical Society, 2007, 129 (39), pp.11916-11917. ⟨10.1021/ja0751577⟩ Article dans une revue istex hal-02114815v1
A set of BEST triple-resonance experiments for time-optimized protein resonance assignment Ewen Lescop,Paul Schanda,Bernhard Brutscher Journal of Magnetic Resonance, 2007, 187 (1), pp.163-169. ⟨10.1016/j.jmr.2007.04.002⟩ Article dans une revue istex hal-02116026v1
Automated Spectral Compression for Fast Multidimensional NMR and Increased Time Resolution in Real-Time NMR Spectroscopy Ewen Lescop,Paul Schanda,Rodolfo Rasia,Bernhard Brutscher Journal of the American Chemical Society, 2007, 129 (10), pp.2756-2757. ⟨10.1021/ja068949u⟩ Article dans une revue istex hal-02118645v1
Conformational Fluctuations Coupled to the Thiol-Disulfide Transfer between Thioredoxin and Arsenate Reductase in Bacillus subtilis You Li,Yunfei Hu,Xinxin Zhang,Huimin Xu,Ewen Lescopet al. Journal of Biological Chemistry, 2007, 282 (15), pp.11078-11083. ⟨10.1074/jbc.M700970200⟩ Article dans une revue hal-02116003v1
Sensitivity-optimized experiment for the measurement of residual dipolar couplings between amide protons Paul Schanda,Ewen Lescop,Mirjam Falge,Rémy Sounier,Jérôme Boisbouvieret al. Journal of Biomolecular NMR, 2007, 38 (1), pp.47-55. ⟨10.1007/s10858-006-9138-2⟩ Article dans une revue istex hal-02116021v1
The Solution Structure of Escherichia coli Wzb Reveals a Novel Substrate Recognition Mechanism of Prokaryotic Low Molecular Weight Protein-tyrosine Phosphatases Xinxin Zhang,Xianrong Guo,You Li,Ewen Lescop,Yunfei Huet al. Journal of Biological Chemistry, 2006, 281 (28), pp.19570-19577. ⟨10.1074/jbc.M601263200⟩ Article dans une revue hal-02116001v1
The Bacillus subtilis YkuV Is a Thiol:Disulfide Oxidoreductase Revealed by Its Redox Structures and Activity Xinxin Zhang,Yunfei Hu,Xianrong Guo,Ewen Lescop,You Liet al. Journal of Biological Chemistry, 2006, 281 (12), pp.8296-8304. ⟨10.1074/jbc.M512015200⟩ Article dans une revue hal-02115994v1
Novel Azapeptide Inhibitors of Hepatitis C Virus Serine Protease Murray Bailey,Ted Halmos,Nathalie Goudreau,Ewen Lescop,Montse Llinàs-Brunet Journal of Medicinal Chemistry, 2004, 47 (15), pp.3788-3799. ⟨10.1021/jm049864b⟩ Article dans une revue istex hal-02118644v1
1H, 13C and 15N chemical shift assignment of the honeybee odorant-binding protein ASP2. Ewen Lescop,Loïc Briand,Jean-Claude Pernollet,Carine van Heijenoort,Eric Guittet Journal of Biomolecular NMR, 2001, 21 (2), pp.181-182. ⟨10.1023/A:1012428527813⟩ Article dans une revue istex hal-02115990v1
Isotopic Double-Labeling of Two Honeybee Odorant-Binding Proteins Secreted by the Methylotrophic Yeast Pichia pastoris Loïc Briand,Ewen Lescop,Valérie Bézirard,Nicolas Birlirakis,Jean-Claude Huetet al. Protein Expression and Purification, 2001, 23 (1), pp.167-174. ⟨10.1006/prep.2001.1478⟩ Article dans une revue istex hal-02115992v1
Isotopic double-labeling of two honeybee odorant-binding proteins secreted by the methylotrophic yeast Pichia pastoris Loïc Briand,Ewen Lescop,Valérie Bézirard,Nicolas Birlirakis,Jean-Claude Huetet al. Protein Expression and Purification, 2001, 23, pp.167-174 Article dans une revue hal-02671654v1

Communication dans un congrès (30)

RMN multi-dimensionnelle et techniques rapides Ewen Lescop,Guillaume Laurent,Patrick Giraudeau Ecole du GERM 2024, Mar 2024, Cargese (Corse), France Communication dans un congrès hal-04932630v1
NMR Paramagnetic effects of lanthanide complexes under high hydrostatic pressure to probe the structure of proteins and contrast agents. François Giraud,Anthony Potenza,Philippe Durand,Xu Dong,Wenxue Jianget al. Journées Scientifiques CENTRA, Association CENTRA, Feb 2024, Gif-sur-Yvette, France Communication dans un congrès hal-04484744v1
Molecular bases of the specific recognition of tRNA by cyclodipeptide synthases: Use of RNA microhelices to mimick tRNA acceptor stem Zahra Marouf,Paloma Fernandez Varela,Carine Tellier,Matthieu Glousieau,Nelly Morelletet al. Journée ED ITFA, ED ITFA, Jun 2023, Orsay, France Communication dans un congrès hal-04397018v1
Probing the coupled dynamics between lipids and membrane proteins in nanodiscs by high-pressure NMR spectroscopy Alexandre Pozza,François Giraud,Quentin Cece,Marina Casiraghi,Elodie Pointet al. 22ème congrès du Groupe français des membranes (GEM), SFB/GEM, Mar 2023, Autrans, France Communication dans un congrès hal-04396785v1
NMR to probe (bio)molecules-light interactions: application to fluorescent proteins? Theo Beguin,Francois Giraud,Marie Erard,Hélène Pasquier,Ewen Lescop LM@W 2023 symposium, LM@W, Oct 2023, Gif-sur-Yvette, France Communication dans un congrès hal-04396805v1
Probing the coupled dynamics between lipids and membrane proteins in nanodiscs by high-pressure NMR spectroscopy Alexandre Pozza,François Giraud,Quentin Cece,Marina Casiraghi,Elodie Pointet al. Congrès BSI, AFC/SFB, Nov 2023, Marseille, France Communication dans un congrès hal-04396783v1
FUNCTIONAL, STRUCTURAL AND BINDING STUDIES OF THE ATYPICAL ER-RESIDENT PROTEIN FKBP7, A POTENTIAL TARGET IN CHEMORESISTANT PROSTATE CANCER. Luce Dreno,Farès Ousalem,Besimé Celik,Carolina Tiraboschi,Yohann Loriotet al. Congrès ARTP, ARTP, Nov 2023, Paris, France Communication dans un congrès hal-04397195v1
Do lipids and proteins affect each other's dynamics in biomembranes? Insights at atomic resolution from high-pressure NMR studies Alexandre Pozza,François Giraud,Quentin Cece,Marina Casiraghi,Elodie Pointet al. journée plateforme RMN CEISAM, CEISAM, Jun 2023, Nantes, France Communication dans un congrès hal-04396788v1
Probing lipid/protein interactions under High-Pressure NMR François Giraud,Alexandre Pozza,Quentin Cece,Marina Casiraghi,Elodie Pointet al. GERM 2023 Résonance Magnétique aux extrêmes, GERM, Jun 2023, Murol, France Communication dans un congrès hal-04429995v1
Deciphering the interactions of Cyclodipeptide Synthases with their shortened tRNA substrates by NMR, X-ray crystallography and biophysical approaches Zahra Marouf,Paloma Fernandez Varela,Carine Tellier,Matthieu Glousieau,Nelly Morelletet al. Journée BSI@Paris-Saclay, Réseau BSI@Paris-Saclay, Nov 2022, Gif-sur-Yvette, France Communication dans un congrès hal-04396986v1
Exploration de l'interaction dynamique entre les lipides et les protéines membranaires par spectroscopie RMN à haute pression François Giraud,Alexandre Pozza,Quentin Cece,Marina Casiraghi,Elodie Pointet al. 13ème FORUM de technologies des HAUTES PRESSIONS, RESEAU HP, Jun 2022, Blériot-Plage, France Communication dans un congrès hal-04429875v1
Probing the coupled dynamics between lipids and membrane proteins in nanodiscs by high-pressure NMR spectroscopy Alexandre Pozza,Francois Giraud,Quentin Cece,Marina Casiraghi,Elodie Pointet al. Journée utilisateurs Infranalytics, Infranalytics, Nov 2022, Marseille, France Communication dans un congrès hal-04396762v1
Probing the coupled dynamics between lipids and membrane proteins in nanodiscs by high-pressure NMR spectroscopy Alexandre Pozza,François Giraud,Quentin Cece,Marina Casiraghi,Elodie Pointet al. GDR Protéine membranaire Appicom, GDR Protéine membranaire Appicom, Oct 2022, Dourdan, France Communication dans un congrès hal-04396757v1
Binding of the Cancer-Related TCTP Protein to Mcl-1/Bcl-xL Requires and Triggers an Order-to-Disorder Transition to Make its BH3 Region Accessible Florian Malard,Christina Sizun,Eric Jacquet,Aurélien Thureau,Ludovic Carlieret al. Colloque Piramid, Piramid, Sep 2021, Nantes (44000), France Communication dans un congrès hal-04396414v1
FUNCTIONAL, STRUCTURAL AND BINDING STUDIES OF THE ATYPICAL ER-RESIDENT PROTEIN FKBP7, A POTENTIAL TARGET IN CHEMORESISTANT PROSTATE CANCER Luce Dreno,Marine Garrido,Matthieu Bertrand,Sofia Calpe,Mariana Tannouryet al. journée ED 582, ED582 Paris-Saclay, Nov 2021, Gif-sur-Yvette, France Communication dans un congrès hal-04396931v1
TCTP is an anti-apoptotic protein containing a BH3-like motif Florian Malard,Christina Sizun,Eric Jacquet,Aurélien Thureau,Ludovic Carlieret al. ENC, ENC, Mar 2021, Online, United States Communication dans un congrès hal-04396413v1
Atomic level description of the Binding of the Cancer-Related TCTP Protein to the sertraline drug and to the anti-apoptotic Mcl-1 protein Florian Malard,Eric Jacquet,Naima Nhiri,Christina Sizun,Amélie Chabrieret al. Biotechnocentre, Biotechnocentre, Oct 2021, Chaumont sur Tharonne, France Communication dans un congrès hal-04396389v1
Etude d'interactions lipides / protéines membranaires par RMN à haute pression Alexandre Pozza,François Giraud,Quentin Cece,Marina Casiraghi,Elodie Pointet al. Journée HP "Biologie sous pression : développement de cellules et métrologie", Forum haute pression, Dec 2021, Paris, France Communication dans un congrès hal-04396766v1
REGULATION OF EIF4F TRANSLATION INITIATION COMPLEX BY THE PEPTIDYL PROLYL ISOMERASE FKBP7 IN TAXANE-RESISTANT PROSTATE CANCER Luce Dreno,Marine Garrido,Mariana Tannoury,Matthieu Bertrand,Nadine Assriret al. 2ème journée scientifique de l'institut de Recherche sur le Médicament et l'Innovation Thérapeutique, IRMIT, Dec 2020, Online, France Communication dans un congrès hal-04396926v1
Using NMR for the structural and kinetic characterization of peptide - liposome associations to support formulation design Camille Doyen,Eric Larquet,Pierre-Damien Coureux,Oriane Frances,Frédéric Hermanet al. Réunion RMN Ile de France, Sep 2020, Gif-sur-Yvette, France Communication dans un congrès hal-04396378v1
A well-balanced preexisting equilibrium governs maximal electron flux efficiency of a multidomain diflavin reductase. Oriane Frances,Fataneh Fatemi,Denis Pompon,Eric Guittet,Christina Sizunet al. Asia-Pacific NMR conference, Jul 2019, Singapour, Singapore Communication dans un congrès hal-04396350v1
METHODES (RAPIDES) POUR DES ETUDES DE RMN SOUS PRESSION Ewen Lescop Congrès GERM, GERM, May 2019, Oléron, France Communication dans un congrès hal-04396354v1
The molecular mechanism of the interaction between TCTP and the Bcl-2 proteins (Bcl-xL, Mcl-1) in the context of tumor reversion Florian Malard,Christina Sizun,Eric Jacquet,Aurélien Thureau,Ludovic Carlieret al. Congrès BSI, AFC/SFB, Nov 2019, Toulouse, France Communication dans un congrès hal-04396359v1
Pharmacology of tumor reversion at TCTP protein: interaction studies, limitation and future Florian Malard,Christina Sizun,Eric Jacquet,Aurélien Thureau,Ludovic Carlieret al. 8eme Colloque Annuel du LabEx LERMIT, LERMIT, Nov 2019, Gif-sur-Yvette, France Communication dans un congrès hal-04396325v1
Deciphering at the atomic level the protein/protein interaction network between the cancer targets TCTP and Bcl-2 proteins Bcl-xL and Mcl-1 by NMR spectroscopy and other structural approaches. Florian Malard,Christina Sizun,Eric Jacquet,Aurélien Thureau,Ludovic Carlieret al. International cancer and ageing conference, HUST Wuhan, Oct 2019, Wuhan, China Communication dans un congrès hal-04396348v1
Towards NMR characterization of apelin encapsulated in liposomes Camille Doyen,Eric Larquet,Pierre-Damien Coureux,Oriane Frances,Frédéric Hermanet al. Réunion RMN@UPSAY, May 2019, Gif-sur-Yvette, France Communication dans un congrès hal-04396367v1
NMR spectroscopy: a powerful and essential tool for diagnosis, drug discovery and development Ewen Lescop Inauguration 800MHz Sanofi, Sanofi, Mar 2018, Vitry-sur-Seine, France Communication dans un congrès hal-04396328v1
Nuclear Magnetic Resonance (NMR) as a tool to probe the structure/DYNAMICS/function of proteins Ewen Lescop Convention on Innovative therapeutics for Cancer and Ageing diseases, Hust Wuhan, Oct 2018, Wuhan, China Communication dans un congrès hal-04396339v1
Redox and pH control of the human iron-sulfur repair protein MitoNEET activity via its iron-sulfur cluster. Cecile Mons,Ioana Ferecatu,Sylvie Riquier,Ewen Lescop,Cécile Boutonet al. ICMRBS, Aug 2018, Dublin (Ireland), Ireland Communication dans un congrès hal-04396332v1
Structural basis of the broad specificity of a general odorant-binding protein from honeybee Ewen Lescop,Loïc Briand,J Claude Pernollet,Eric Guittet 34. Congress of the Federation of European Biochemical Societies, Jul 2009, Prague, Czech Republic. ⟨10.1021/bi802300k⟩ Communication dans un congrès hal-02758513v1

Poster de conférence (17)

Molecular basis of the specific recognition of tRNA substrates by cyclodipeptide synthases explored using RNA microhelices Zahra Marouf,Paloma Fernandez Varela,Carine Tellier,Matthieu Glousieau,Pierre Legrandet al. Congrès BSI, Nov 2023, Marseille, France Poster de conférence hal-04397161v1
FUNCTIONAL, STRUCTURAL AND BINDING STUDIES OF THE ATYPICAL ER-RESIDENT PROTEIN FKBP7, A POTENTIAL TARGET IN CHEMORESISTANT PROSTATE CANCER. Luce Dreno,Farès Ousalem,Besimé Celik,Carolina Tiraboschi,Yohann Loriotet al. Journées Jeunes Chercheurs ARC, Oct 2023, Paris, France Poster de conférence hal-04397185v1
Probing the coupled dynamics between lipids and membrane proteins by high-pressure NMR spectroscopy Alexandre Pozza,François Giraud,Quentin Cece,Marina Casiraghi,Elodie Pointet al. Euromar, Jul 2022, Utrecht, Netherlands Poster de conférence hal-04396751v1
Functional, structural, and binding studies of the atypical ER-resident protein FKBP7, a potential target in chemoresistant-prostate cancer Luce Dreno,Sofian Lacoste,Carolina Tiraboschi,Sofia Calpe,Marine Garridoet al. AACR Annual Meeting, Apr 2022, New Orleans, United States Poster de conférence hal-04396828v1
Structural and functional studies of cyclodipeptide synthases with RNA microhelices mimicking their tRNA susbtrates. Zahra Marouf,Paloma Fernandez Varela,Carine Tellier,Matthieu Glousieau,Jérôme Séguinet al. 33ème édition de la Conférence Européenne de Cristallographie (ECM33), Aug 2022, Versailles, France Poster de conférence hal-04397149v1
FUNCTIONAL, STRUCTURAL AND BINDING STUDIES OF THE ATYPICAL ER-RESIDENT PROTEIN FKBP7, A POTENTIAL TARGET IN CHEMORESISTANT PROSTATE CANCER Luce Dreno,Sofian Lacoste,Carolina Tiraboschi,Marine Garrido,Mariana Tannouryet al. Journée Scientifique ARTP, Nov 2022, Paris, France Poster de conférence hal-04396877v1
Structural studies of cyclodipeptide synthases with RNA microhelices mimicking their natural tRNA susbtrates Zahra Marouf,Nelly Morellet,Carine Tellier,Matthieu Glousieau,Eric Jacquetet al. congrès BSI, Nov 2021, Gif-sur-Yvette, France Poster de conférence hal-04397035v1
ParaHP-NMR: Paramagnetic effects under high hydrostatic pressure NMR to probe the structure of proteins and contrast agents. François Giraud,Anthony Potenza,Philippe Durand,Xu Dong,Wenxue Jianget al. Congrès BSI, Nov 2021, Gif-sur-Yvette, France Poster de conférence hal-04396420v1
High-Pressure NMR to probe protein and lipid bilayer structure/dynamics Alexandre Pozza,François Giraud,Quentin Cece,Marina Casiraghi,Elodie Pointet al. Congrès BSI, Nov 2021, Gif-sur-Yvette, France Poster de conférence hal-04396409v1
The ER-resident FKBP7: a new candidate for the Endoplasmic Reticulum to Cytosol Signaling (ERCYS) pathway? Luce Dreno,Marine Garrido,Matthieu Bertrand,Sofia Calpe,Mariana Tannouryet al. Endoplasmic Reticulum 2021 symposium, Oct 2021, Paris, France Poster de conférence hal-04396910v1
La RMN sous pression hydrostatique: un outil pour caractériser la structure et la dynamique de biomolécules. Giraud François,Dong Xu,Gong Zhou,Chun Tang,Ewen Lescop Forum haute pression, Oct 2020, Oléron, France Poster de conférence hal-04396383v1
Real-time, in situ peptide-liposome formulation release kinetics monitored by NMR spectroscopy Camille Doyen,Eric Larquet,Pierre-Damien Coureux,Oriane Frances,Frédéric Hermanet al. COMET, Feb 2019, Cergy, France Poster de conférence hal-04396372v1
Interaction of the Cysteine-Rich Domain of the Paramecium domesticated transposase PiggyMac with histone H3 Luiza Mamigonian Bessa,Marc Guérineau,Séverine Moriau,Nadine Assrir,Ewen Lescopet al. 11th Conference “NMR: a tool for Biology”, Jan 2019, Paris, France. 46, pp.2660-2677, 2018 Poster de conférence hal-04381885v1
IN SITU PEPTIDE RELEASE KINETICS FROM LIPOSOME FORMULATION MONITORED BY NMR SPECTROSCOPY Camille Doyen,Eric Larquet,Pierre-Damien Coureux,Oriane Frances,Frédéric Hermanet al. EUROISMAR, Aug 2019, Berlin (DE), Germany Poster de conférence hal-04396375v1
NMR study of the structure and dynamics of the intrinsically disordered tail of ErbB2, phosphorylation and interaction Carine van Heijenoort,Louise Pinet,Yinghui Wang,Ewen Lescop,Francoise Guerlesquinet al. XXVIIIth International Conference on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland Poster de conférence hal-04435655v1
Towards NMR characterization of apelin encapsulated in liposomes. Camille Doyen,Eric Larquet,Pierre-Damien Coureux,Oriane Frances,Frédéric Hermanet al. Euromar, Aug 2018, Nantes, France Poster de conférence hal-04396376v1
ASP2 : une protéine qui a du flair. Ewen Lescop,Loïc Briand,J Claude Pernollet,Eric Guittet 17. Congrès annuel du Groupe Français d'Etudes de Résonance Magnétique, May 2001, La Pommeraye, France. 1 p., 2001 Poster de conférence hal-02830664v1

Autre publication scientifique (5)

Probing the coupled dynamics between lipids and membrane proteins in nanodiscs by high-pressure NMR spectroscopy Ewen Lescop 2023 Autre publication scientifique hal-04484747v1
Deciphering at the atomic level the protein/protein interaction network between the cancer targets TCTP and Bcl-2 proteins Bcl-xL and Mcl-1 by NMR spectroscopy and other structural approaches. Ewen Lescop 2019 Autre publication scientifique hal-04484742v1
The molecular mechanism of the interaction between the cancer-related TCTP and Bcl-2 proteins Bcl-xL and Mcl-1. Ewen Lescop 2019 Autre publication scientifique hal-04484743v1
NMR tools to probe conformational energy landscapes Ewen Lescop 2018 Autre publication scientifique hal-04484739v1
Protein dynamics: the missing link between protein structure and function? Contributions from NMR spectroscopy Ewen Lescop 2018 Autre publication scientifique hal-04484740v1

Chapitre d'ouvrage (1)

Structural Insights into TCTP and Its Interactions with Ligands and Proteins Nadine Assrir,Florian Malard,Ewen Lescop TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease, pp.9-46, 2017, ⟨10.1007/978-3-319-67591-6_2⟩ Chapitre d'ouvrage hal-02309075v1

Thèse (1)

Etude par Résonance Magnétique Nucléaire de macromolécules biologiques: structure, dynamique et interactions. Application à une protéine de liaison aux odeurs Ewen Lescop Biochimie [q-bio.BM]. Université Paris Sud - Paris XI, 2003. Français. ⟨NNT : ⟩ Thèse tel-00006777v1