Fabien Pierrel

Publications

Article dans une revue (58)

Heterologous plastoquinone production using a newly identified O 2 ‐dependent cyanobacterial hydroxylase Morgane Roger-Margueritat,Margot Beltran,Juliette Schnoebelen,Laura Flandrin,Wafa Rezaliet al. FEBS Journal, 2025, ⟨10.1111/febs.70272⟩ Article dans une revue hal-05302505v1
A scaffold for quinone channeling between membrane and soluble bacterial oxidoreductases M. Broc,M. Cherrier,A. Uzel,R. Arias-Cartin,P. Arnouxet al. Nature Structural and Molecular Biology, 2025, 32, pp.2196-2202. ⟨10.1038/s41594-025-01607-4⟩ Article dans une revue hal-05229188v1
Dynamic quinone repertoire accompanied the diversification of energy metabolism in Pseudomonadota Sophie-Carole Chobert,Morgane Roger-Margueritat,Laura Flandrin,Safa Berraies,Christopher T. Lefèvreet al. The International Society of Microbiologial Ecology Journal, 2025, 19 (1), ⟨10.1093/ismejo/wrae253⟩ Article dans une revue hal-04886577v1
A novel quinone biosynthetic pathway illuminates the evolution of aerobic metabolism Felix J Elling,Fabien Pierrel,Sophie-Carole Chobert,Sophie S Abby,Thomas W Evanset al. Proceedings of the National Academy of Sciences of the United States of America, 2025, 122 (8), pp.e2421994122. ⟨10.1073/pnas.2421994122⟩ Article dans une revue hal-04679398v2
An organic O donor for biological hydroxylation reactions Katayoun Kazemzadeh Ferizhendi,Philippe Simon,Ludovic Pelosi,Emmanuel Séchet,Roache Arulanandamet al. Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (13), pp.e2321242121. ⟨10.1073/pnas.2321242121⟩ Article dans une revue pasteur-04665824v1
COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells Ludovic Pelosi,Laura Morbiato,Arthur Burgardt,Fiorella Tonello,Abigail Bartlettet al. Molecular Cell, 2024, 84 (5), pp.981-989. ⟨10.1016/j.molcel.2024.01.003⟩ Article dans une revue hal-04450030v1
The acyl-CoA synthetase Tg ACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions Sarah Charital,Serena Shunmugam,Sheena Dass,Anna Maria Alazzi,Christophe-Sébastien Arnoldet al. mBio, 2024, 15 (4), ⟨10.1128/mbio.00427-24⟩ Article dans une revue hal-04779560v1
Structural Reconstruction of E. coli Ubi Metabolon Using an AlphaFold2-Based Computational Framework Romain Launay,Sophie-Carole Chobert,Sophie S Abby,Fabien Pierrel,Isabelle Andréet al. Journal of Chemical Information and Modeling, 2024, 64 (13), pp.5175-5193. ⟨10.1021/acs.jcim.4c00304⟩ Article dans une revue hal-04662598v1
Spatial heterogeneity for APRIL production by eosinophils in the small intestine Nathalie Sturm,Morgane Roger-Margueritat,Fabien Pierrel,Philippe Lehours,Muriel Genevayet al. Journal of Leukocyte Biology, 2023, 113 (4), pp.376-382. ⟨10.1093/jleuko/qiad014⟩ Article dans une revue hal-04213714v1
Diversification of ubiquinone biosynthesis via gene duplications, transfers, losses, and parallel evolution Katayoun Kazemzadeh,Ludovic Pelosi,Clothilde Chenal,Sophie-Carole Chobert,Mahmoud Hajj Chehadeet al. Molecular Biology and Evolution, 2023, 40 (10), pp.msad219. ⟨10.1093/molbev/msad219⟩ Article dans une revue hal-04256893v1
Role of the Escherichia coli ubiquinone-synthesizing UbiUVT pathway in adaptation to changing respiratory conditions Rodrigo Arias-Cartin,Katayoun Kazemzadeh Ferizhendi,Emmanuel Séchet,Ludovic Pelosi,Corinne Loeuilletet al. mBio, 2023, 14 (4), pp.e0329822. ⟨10.1128/mbio.03298-22⟩ Article dans une revue hal-04213722v2
Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2 Vinzent Schulz,Somsuvro Basu,Sven-A. Freibert,Holger Webert,Linda Bosset al. Nature Chemical Biology, 2022, ⟨10.1038/s41589-022-01159-4⟩ Article dans une revue hal-03836706v1
Towards Molecular Understanding of the Functional Role of UbiJ-UbiK2 Complex in Ubiquinone Biosynthesis by Multiscale Molecular Modelling Studies Romain Launay,Elin Teppa,Carla Martins,Sophie S Abby,Fabien Pierrelet al. International Journal of Molecular Sciences, 2022, 23 (18), ⟨10.3390/ijms231810323⟩ Article dans une revue hal-03800688v1
Rational Engineering of Non-Ubiquinone Containing Corynebacterium glutamicum for Enhanced Coenzyme Q10 Production Arthur Burgardt,Ludovic Pelosi,Mahmoud Hajj Chehade,Volker Wendisch,Fabien Pierrel Metabolites, 2022, 12 (5), pp.428. ⟨10.3390/metabo12050428⟩ Article dans une revue hal-03677651v1
Identification and characterization of a non-canonical menaquinone-linked formate dehydrogenase Rodrigo Arias-Cartin,Alexandre Uzel,Farida Seduk,Guillaume Gerbaud,Fabien Pierrelet al. Journal of Biological Chemistry, 2022, 298 (2), pp.101384. ⟨10.1016/j.jbc.2021.101384⟩ Article dans une revue hal-03431446v1
Recent advances in the metabolic pathways and microbial production of coenzyme Q Fabien Pierrel,Arthur Burgardt,Jin-Ho Lee,Ludovic Pelosi,Volker Wendisch World Journal of Microbiology and Biotechnology, 2022, 38 (4), pp.58. ⟨10.1007/s11274-022-03242-3⟩ Article dans une revue hal-03677653v1
The [PSI + ] prion modulates cytochrome c oxidase deficiency caused by deletion of COX12 Pawan Kumar Saini,Hannah Dawitz,Andreas Aufschnaiter,Stanislav Bondarev,Jinsu Thomet al. Molecular Biology of the Cell, 2022, ⟨10.1091/mbc.E21-10-0499⟩ Article dans une revue hal-03836554v1
Manganese-driven CoQ deficiency Jutta Diessl,Jens Berndtsson,Filomena Broeskamp,Lukas Habernig,Verena Kohleret al. Nature Communications, 2022, 13 (1), pp.6061. ⟨10.1038/s41467-022-33641-x⟩ Article dans une revue hal-03836582v1
The biosynthetic pathway of ubiquinone contributes to pathogenicity of Francisella Running title: Ubiquinone and Francisella pathogenicity Katayoun Kazemzadeh,Mahmoud Hajj Chehade,Gautier Hourdoir,Camille Dorothée Brunet,Yvan Casparet al. Journal of Bacteriology, 2021, ⟨10.1128/JB.00400-21⟩ Article dans une revue hal-03357541v1
Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage Sheena Dass,Serena Shunmugam,Laurence Berry,Christophe-Sebastien Arnold,Nicholas Katriset al. Nature Communications, 2021, 12, pp.2813. ⟨10.1038/s41467-021-22956-w⟩ Article dans une revue hal-03456819v1
The controversy on the ancestral arsenite oxidizing enzyme; deducing evolutionary histories with phylogeny and thermodynamics Julie Szyttenholm,Florence Chaspoul,Marielle Bauzan,Anne-Lise Ducluzeau,Mahmoud Hajj Chehadeet al. Biochimica biophysica acta (BBA) - Bioenergetics, 2020, 1861 (10), pp.148252. ⟨10.1016/j.bbabio.2020.148252⟩ Article dans une revue hal-02896357v1
The O2-independent pathway of ubiquinone biosynthesis is essential for denitrification in Pseudomonas aeruginosa Chau-Duy-Tam Vo,Julie Michaud,Sylvie Elsen,Bruno Faivre,Emmanuelle Bouveretet al. Journal of Biological Chemistry, 2020, 295 (27), pp.9021-9032. ⟨10.1074/jbc.RA120.013748⟩ Article dans une revue pasteur-02746713v1
Advances in bacterial pathways for the biosynthesis of ubiquinone Sophie S. Abby,Katayoun Kazemzadeh,Charles Vragniau,Ludovic Pelosi,Fabien Pierrel Biochimica biophysica acta (BBA) - Bioenergetics, 2020, 1861 (11), pp.148259. ⟨10.1016/j.bbabio.2020.148259⟩ Article dans une revue hal-02944115v1
PasT of Escherichia coli sustains antibiotic tolerance and aerobic respiration as a bacterial homolog of mitochondrial Coq10 Cinzia Fino,Martin Vestergaard,Hanne Ingmer,Fabien Pierrel,Kenn Gerdeset al. MicrobiologyOpen, 2020, ⟨10.1002/mbo3.1064⟩ Article dans une revue hal-02896344v1
Ubiquinone Biosynthesis over the Entire O2 Range: Characterization of a Conserved O2-Independent Pathway Ludovic Pelosi,Chau-Duy-Tam Vo,Sophie Saphia Abby,Laurent Loiseau,Bérengère Rascalouet al. mBio, 2019, 10 (4), ⟨10.1128/mBio.01319-19⟩ Article dans une revue hal-02183791v1
Vanillic Acid Restores Coenzyme Q Biosynthesis and ATP Production in Human Cells Lacking COQ6 Manuel Acosta Lopez,Eva Trevisson,Marcella Canton,Luis Vazquez-Fonseca,Valeria Morbidoniet al. Oxidative Medicine and Cellular Longevity, 2019, 2019, pp.1-11. ⟨10.1155/2019/3904905⟩ Article dans une revue hal-02323996v1
Vitamin K2 cannot substitute Coenzyme Q10 as electron carrier in the mitochondrial respiratory chain of mammalian cells Cristina Cerqua,Alberto Casarin,Fabien Pierrel,Luis Vazquez Fonseca,Giampiero Violaet al. Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-43014-y⟩ Article dans une revue hal-02324041v1
A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone Mahmoud Hajj Chehade,Ludovic Pelosi,Cameron David Fyfe,Laurent Loiseau,Bérengère Rascalouet al. Cell Chemical Biology, 2019, 26 (4), pp.482-492.e7. ⟨10.1016/j.chembiol.2018.12.001⟩ Article dans une revue hal-02071798v1
The COQ2 genotype predicts the severity of coenzyme Q 10 deficiency Maria Andrea Desbats,Valeria Morbidoni,Micol Silic-Benussi,Mara Doimo,Vincenzo Ciminaleet al. Human Molecular Genetics, 2017, 25 (19), pp.4256 - 4265. ⟨10.1093/hmg/ddw257⟩ Article dans une revue hal-01635280v1
Impact of Chemical Analogs of 4-Hydroxybenzoic Acid on Coenzyme Q Biosynthesis: From Inhibition to Bypass of Coenzyme Q Deficiency Fabien Pierrel Frontiers in Physiology, 2017, 87, pp.80 - 80. ⟨10.3389/fphys.2017.00436⟩ Article dans une revue hal-01583835v1
The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ Laurent Loiseau,Cameron Fyfe,Laurent Aussel,Mahmoud Hajj Chehade,Sara B. Hernándezet al. Journal of Biological Chemistry, 2017, 292 (28), pp.11937 - 11950. ⟨10.1074/jbc.M117.789164⟩ Article dans une revue hal-01615493v1
Coenzyme Q Biosynthesis: Evidence for a Substrate Access Channel in the FAD-Dependent Monooxygenase Coq6 Alexandre Ismail,Vincent Leroux,Myriam Smadja,Lucie Gonzalez,Murielle Lombardet al. PLoS Computational Biology, 2016, 12 (1), pp.e1004690. ⟨10.1371/journal.pcbi.1004690⟩ Article dans une revue hal-01424489v1
Evolution of Ubiquinone Biosynthesis: Multiple Proteobacterial Enzymes with Various Regioselectivities To Catalyze Three Contiguous Aromatic Hydroxylation Reactions Ludovic Pelosi,Anne-Lise Ducluzeau,Laurent Loiseau,Frédéric Barras,Dominique Schneideret al. mSystems, 2016, 1 (4), pp.00091-16. ⟨10.1128/mSystems.00091-16⟩ Article dans une revue hal-01424513v1
Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast Laurie-Anne Payet,Mélanie Leroux,John C. Willison,Akio Kihara,Ludovic Pelosiet al. Cell Chemical Biology, 2016, 23 (10), pp.1241 - 1250. ⟨10.1016/j.chembiol.2016.08.008⟩ Article dans une revue hal-01424510v1
Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity Jonathan a. Stefely,Floriana Licitra,Leila Laredj,Andrew g. Reidenbach,Zachary a. Kemmereret al. Molecular Cell, 2016, 63 (4), pp.608 - 620. ⟨10.1016/j.molcel.2016.06.030⟩ Article dans une revue hal-01424495v1
Demethylmenaquinol is a substrate of Escherichia coli nitrate reductase A (NarGHI) and forms a stable semiquinone intermediate at the NarGHI quinol oxidation site Julia Rendon,Eric Pilet,Zeinab Fahs,Farida Seduk,Léa Sylviet al. Biochimica biophysica acta (BBA) - Bioenergetics, 2015, 1847 (8), pp.739-747. ⟨10.1016/j.bbabio.2015.05.001⟩ Article dans une revue hal-01429032v1
Coq6 Is Responsible for the C4-deamination Reaction in Coenzyme Q Biosynthesis in Saccharomyces cerevisiae * Mohammad Ozeir,Ludovic Pelosi,Alexandre Ismail,Caroline Mellot-Draznieks,Marc Fontecaveet al. Journal of Biological Chemistry, 2015, ⟨10.1074/jbc.M115.675744⟩ Article dans une revue hal-01424487v1
Biosynthesis and physiology of coenzyme Q in bacteria. Laurent Aussel,Fabien Pierrel,Laurent Loiseau,Murielle Lombard,Marc Fontecaveet al. Biochimica biophysica acta (BBA) - Bioenergetics, 2014, 1837 (7), pp.1004-1011. ⟨10.1016/j.bbabio.2014.01.015⟩ Article dans une revue hal-01077983v1
ubiJ, a New Gene Required for Aerobic Growth and Proliferation in Macrophage, Is Involved in Coenzyme Q Biosynthesis in Escherichia coli and Salmonella enterica Serovar Typhimurium. Laurent Aussel,Laurent Loiseau,Mahmoud Hajj Chehade,Bérengère Pocachard,Marc Fontecaveet al. Journal of Bacteriology, 2014, 196 (1), pp.70-79. ⟨10.1128/JB.01065-13⟩ Article dans une revue hal-00917119v1
Three conserved histidyl residues contribute to mitochondrial iron transport through mitoferrins. Xavier Brazzolotto,Fabien Pierrel,Ludovic Pelosi Biochemical Journal, 2014, 460 (1), pp.79-89. ⟨10.1042/BJ20140107⟩ Article dans une revue hal-00961552v1
A new gene involved in coenzyme Q biosynthesis in Escherichia coli: UbiI functions in aerobic C5-hydroxylation Mahmoud Hajj Chehade,Laurent Loiseau,Murielle Lombard,Ludovic Pecqueur,Alexandre Ismailet al. Journal of Biological Chemistry, 2013, 288 (27), pp.20085-92. ⟨10.1074/jbc.M113.480368⟩ Article dans une revue hal-00904907v1
Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency. Mara Doimo,Eva Trevisson,Rannar Airik,Marc Bergdoll,Carlos Santos-Ocañaet al. BBA - Biochimica et Biophysica Acta, 2013, 1842 (1), pp.1-6. ⟨10.1016/j.bbadis.2013.10.007⟩ Article dans une revue hal-00904926v1
In vivo accumulation of coenzyme Q biosynthetic intermediates and aminated analogs in the yeast Saccharomyces cerevisiae Mohammad Ozeir Ozeir,Letian X. Xie,Mahmoud Hajj Chehade,Jeniffer Y. Tang,Sylvie-Kieffer Jacquinodet al. Biochimica biophysica acta (BBA) - Bioenergetics, 2012, 1817, pp.S92-S92. ⟨10.1016/j.bbabio.2012.06.249⟩ Article dans une revue hal-01236935v1
Overexpression of the Coq8 kinase in Saccharomyces cerevisiae coq null mutants allows for accumulation of diagnostic intermediates of the coenzyme Q6 biosynthetic pathway. Letian X Xie,Mohammad Ozeir,Jeniffer y Tang,Jia y Chen,Sylvie-Kieffer Jaquinodet al. Journal of Biological Chemistry, 2012, 287 (28), pp.23571-81. ⟨10.1074/jbc.M112.360354⟩ Article dans une revue hal-00904902v1
Coenzyme q biosynthesis: coq6 is required for the c5-hydroxylation reaction and substrate analogs rescue coq6 deficiency. Mohammad Ozeir,Ulrich Mühlenhoff,Holger Webert,Roland Lill,Marc Fontecaveet al. Chem Biol, 2011, 18 (9), pp.1134-42. ⟨10.1016/j.chembiol.2011.07.008⟩ Article dans une revue hal-00630764v1
Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis. Fabien Pierrel,Olivier Hamelin,Thierry Douki,Sylvie Kieffer-Jaquinod,Ulrich Mühlenhoffet al. Chem Biol, 2010, 17 (5), pp.449-59. ⟨10.1016/j.chembiol.2010.03.014⟩ Article dans une revue hal-00497916v1
Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster. Ulrich Mühlenhoff,Sabine Molik,José R Godoy,Marta A Uzarska,Nadine Richteret al. Cell Metabolism, 2010, 12 (4), pp.373-85. ⟨10.1016/j.cmet.2010.08.001⟩ Article dans une revue hal-00630763v1
The role of Coa2 in hemylation of yeast Cox1 revealed by its genetic interaction with Cox10. Megan Bestwick,Oleh Khalimonchuk,Fabien Pierrel,Dennis R Winge Molecular and Cellular Biology, 2010, 30 (1), pp.172-85. ⟨10.1128/MCB.00869-09⟩ Article dans une revue hal-00497920v1
Isolated cytochrome c oxidase deficiency in G93A SOD1 mice overexpressing CCS protein. Marjatta Son,Scot C Leary,Nadine Romain,Fabien Pierrel,Dennis R Wingeet al. Journal of Biological Chemistry, 2008, 283 (18), pp.12267-75. ⟨10.1074/jbc.M708523200⟩ Article dans une revue hal-00376153v1
Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae. Oleh Khalimonchuk,Kevin Rigby,Megan Bestwick,Fabien Pierrel,Paul A Cobineet al. Eukaryotic Cell, 2008, 7 (8), pp.1427-31. ⟨10.1128/EC.00132-08⟩ Article dans une revue hal-00375432v1
Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1. Fabien Pierrel,Oleh Khalimonchuk,Paul A Cobine,Megan Bestwick,Dennis R Winge Molecular and Cellular Biology, 2008, 28 (16), pp.4927-39. ⟨10.1128/MCB.00057-08⟩ Article dans une revue hal-00375430v1
Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly. Fabien Pierrel,Megan L Bestwick,Paul A Cobine,Oleh Khalimonchuk,Julia A Criccoet al. EMBO Journal, 2007, 26 (20), pp.4335-46. ⟨10.1038/sj.emboj.7601861⟩ Article dans une revue hal-00374057v1
Metal Ion availability in mitochondria. Fabien Pierrel,Paul A Cobine,Dennis R Winge BioMetals, 2007, 20 (3-4), pp.675-82. ⟨10.1007/s10534-006-9052-9⟩ Article dans une revue hal-00375433v1
MiaB, a bifunctional radical-S-adenosylmethionine enzyme involved in the thiolation and methylation of tRNA, contains two essential [4Fe-4S] clusters. Heather L. Hernandez,Fabien Pierrel,Eric Elleingand,Ricardo Garcia-Serres,Boi Hanh Huynhet al. Biochemistry, 2007, 46, pp.5140-5147 Article dans une revue hal-00377635v1
tRNA-modifying MiaE protein from Salmonella typhimurium is a nonheme diiron monooxygenase. Carole Mathevon,Fabien Pierrel,Jean-Louis Oddou,Ricardo Garcia-Serres,Geneviève Blondinet al. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (33), pp.13295-300. ⟨10.1073/pnas.0704338104⟩ Article dans une revue hal-01069738v1
The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding. Paul A Cobine,Fabien Pierrel,Scot C Leary,Florin Sasarman,Yih-Chern Hornget al. Journal of Biological Chemistry, 2006, 281 (18), pp.12270-6. ⟨10.1074/jbc.M600496200⟩ Article dans une revue hal-00376137v1
Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase. Paul A Cobine,Fabien Pierrel,Megan L Bestwick,Dennis R Winge Journal of Biological Chemistry, 2006, 281 (48), pp.36552-9. ⟨10.1074/jbc.M606839200⟩ Article dans une revue hal-00376121v1
Copper trafficking to the mitochondrion and assembly of copper metalloenzymes. Paul A Cobine,Fabien Pierrel,Dennis R Winge Biochimica et Biophysica Acta - Molecular Cell Research, 2006, 1763 (7), pp.759-72. ⟨10.1016/j.bbamcr.2006.03.002⟩ Article dans une revue istex hal-00376149v1

Pré-publication, Document de travail (2)

Global distribution of isoprenoid quinones across Bacteria Sophie-Carole Chobert,Suraj Kanwar,Olivier Lerouxel,Nelle Varoquaux,Julie Michaudet al. 2025 Pré-publication, Document de travail hal-05338460v1
The [PSI+] prion and HSP104 modulate cytochrome c oxidase deficiency caused by deletion of COX12 Pawan Kumar Saini,Hannah Dawitz,Andreas Aufschnaiter,Jinsu Thomas,Amélie Amblardet al. 2021 Pré-publication, Document de travail hal-03402829v1