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A novel quinone biosynthetic pathway illuminates the evolution of aerobic metabolism
Felix J Elling
,
Fabien Pierrel
,
Sophie-Carole Chobert
,
Sophie S Abby
,
Thomas W Evans
et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025, 122 (8), pp.e2421994122. ⟨10.1073/pnas.2421994122⟩
Article dans une revue
hal-04679398
v2
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COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells
Ludovic Pelosi
,
Laura Morbiato
,
Arthur Burgardt
,
Fiorella Tonello
,
Abigail Bartlett
et al.
Article dans une revue
hal-04450030
v1
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An organic O donor for biological hydroxylation reactions
Katayoun Kazemzadeh Ferizhendi
,
Philippe Simon
,
Ludovic Pelosi
,
Emmanuel Séchet
,
Roache Arulanandam
et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (13), pp.e2321242121. ⟨10.1073/pnas.2321242121⟩
Article dans une revue
pasteur-04665824
v1
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The acyl-CoA synthetase Tg ACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions
Sarah Charital
,
Serena Shunmugam
,
Sheena Dass
,
Anna Maria Alazzi
,
Christophe-Sébastien Arnold
et al.
Article dans une revue
hal-04779560
v1
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Structural Reconstruction of E. coli Ubi Metabolon Using an AlphaFold2-Based Computational Framework
Romain Launay
,
Sophie-Carole Chobert
,
Sophie S Abby
,
Fabien Pierrel
,
Isabelle André
et al.
Article dans une revue
hal-04662598
v1
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Activation of Coq6p, a FAD Monooxygenase Involved in Coenzyme Q Biosynthesis, by Adrenodoxin Reductase/Ferredoxin
Lucie Gonzalez
,
Samuel Chau-Duy Tam Vo
,
Bruno Faivre
,
Fabien Pierrel
,
Marc Fontecave
et al.
Article dans une revue
hal-04728040
v1
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Spatial heterogeneity for APRIL production by eosinophils in the small intestine
Nathalie Sturm
,
Morgane Roger-Margueritat
,
Fabien Pierrel
,
Philippe Lehours
,
Muriel Genevay
et al.
Article dans une revue
hal-04213714
v1
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Diversification of ubiquinone biosynthesis via gene duplications, transfers, losses, and parallel evolution
Katayoun Kazemzadeh
,
Ludovic Pelosi
,
Clothilde Chenal
,
Sophie-Carole Chobert
,
Mahmoud Hajj Chehade
et al.
Article dans une revue
hal-04256893
v1
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Role of the Escherichia coli ubiquinone-synthesizing UbiUVT pathway in adaptation to changing respiratory conditions
Rodrigo Arias-Cartin
,
Katayoun Kazemzadeh Ferizhendi
,
Emmanuel Séchet
,
Ludovic Pelosi
,
Corinne Loeuillet
et al.
Article dans une revue
hal-04213722
v2
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Recent advances in the metabolic pathways and microbial production of coenzyme Q
Fabien Pierrel
,
Arthur Burgardt
,
Jin-Ho Lee
,
Ludovic Pelosi
,
Volker Wendisch
Article dans une revue
hal-03677653
v1
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Identification and characterization of a non-canonical menaquinone-linked formate dehydrogenase
Rodrigo Arias-Cartin
,
Alexandre Uzel
,
Farida Seduk
,
Guillaume Gerbaud
,
Fabien Pierrel
et al.
Article dans une revue
hal-03431446
v1
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Towards Molecular Understanding of the Functional Role of UbiJ-UbiK2 Complex in Ubiquinone Biosynthesis by Multiscale Molecular Modelling Studies
Romain Launay
,
Elin Teppa
,
Carla Martins
,
Sophie S Abby
,
Fabien Pierrel
et al.
Article dans une revue
hal-03800688
v1
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Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2
Vinzent Schulz
,
Somsuvro Basu
,
Sven-A. Freibert
,
Holger Webert
,
Linda Boss
et al.
Article dans une revue
hal-03836706
v1
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Rational Engineering of Non-Ubiquinone Containing Corynebacterium glutamicum for Enhanced Coenzyme Q10 Production
Arthur Burgardt
,
Ludovic Pelosi
,
Mahmoud Hajj Chehade
,
Volker Wendisch
,
Fabien Pierrel
Article dans une revue
hal-03677651
v1
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The [PSI + ] prion modulates cytochrome c oxidase deficiency caused by deletion of COX12
Pawan Kumar Saini
,
Hannah Dawitz
,
Andreas Aufschnaiter
,
Stanislav Bondarev
,
Jinsu Thom
et al.
Article dans une revue
hal-03836554
v1
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Manganese-driven CoQ deficiency
Jutta Diessl
,
Jens Berndtsson
,
Filomena Broeskamp
,
Lukas Habernig
,
Verena Kohler
et al.
Article dans une revue
hal-03836582
v1
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Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
Sheena Dass
,
Serena Shunmugam
,
Laurence Berry
,
Christophe-Sebastien Arnold
,
Nicholas Katris
et al.
Article dans une revue
hal-05007579
v1
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The biosynthetic pathway of ubiquinone contributes to pathogenicity of Francisella Running title: Ubiquinone and Francisella pathogenicity
Katayoun Kazemzadeh
,
Mahmoud Hajj Chehade
,
Gautier Hourdoir
,
Camille Dorothée Brunet
,
Yvan Caspar
et al.
Article dans une revue
hal-03357541
v1
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Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
Sheena Dass
,
Serena Shunmugam
,
Laurence Berry
,
Christophe-Sebastien Arnold
,
Nicholas Katris
et al.
Article dans une revue
hal-03456819
v1
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The controversy on the ancestral arsenite oxidizing enzyme; deducing evolutionary histories with phylogeny and thermodynamics
Julie Szyttenholm
,
Florence Chaspoul
,
Marielle Bauzan
,
Anne-Lise Ducluzeau
,
Mahmoud Hajj Chehade
et al.
Article dans une revue
hal-02896357
v1
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Advances in bacterial pathways for the biosynthesis of ubiquinone
Sophie S. Abby
,
Katayoun Kazemzadeh
,
Charles Vragniau
,
Ludovic Pelosi
,
Fabien Pierrel
Article dans une revue
hal-02944115
v1
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The O2-independent pathway of ubiquinone biosynthesis is essential for denitrification in Pseudomonas aeruginosa
Chau-Duy-Tam Vo
,
Julie Michaud
,
Sylvie Elsen
,
Bruno Faivre
,
Emmanuelle Bouveret
et al.
Article dans une revue
pasteur-02746713
v1
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PasT of Escherichia coli sustains antibiotic tolerance and aerobic respiration as a bacterial homolog of mitochondrial Coq10
Cinzia Fino
,
Martin Vestergaard
,
Hanne Ingmer
,
Fabien Pierrel
,
Kenn Gerdes
et al.
Article dans une revue
hal-02896344
v1
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Vitamin K2 cannot substitute Coenzyme Q10 as electron carrier in the mitochondrial respiratory chain of mammalian cells
Cristina Cerqua
,
Alberto Casarin
,
Fabien Pierrel
,
Luis Vazquez Fonseca
,
Giampiero Viola
et al.
Article dans une revue
hal-02324041
v1
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Vanillic Acid Restores Coenzyme Q Biosynthesis and ATP Production in Human Cells Lacking COQ6
Manuel Acosta Lopez
,
Eva Trevisson
,
Marcella Canton
,
Luis Vazquez-Fonseca
,
Valeria Morbidoni
et al.
Article dans une revue
hal-02323996
v1
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Ubiquinone Biosynthesis over the Entire O2 Range: Characterization of a Conserved O2-Independent Pathway
Ludovic Pelosi
,
Chau-Duy-Tam Vo
,
Sophie Saphia Abby
,
Laurent Loiseau
,
Bérengère Rascalou
et al.
Article dans une revue
hal-02183791
v1
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A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone
Mahmoud Hajj Chehade
,
Ludovic Pelosi
,
Cameron David Fyfe
,
Laurent Loiseau
,
Bérengère Rascalou
et al.
Article dans une revue
hal-02071798
v1
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Impact of Chemical Analogs of 4-Hydroxybenzoic Acid on Coenzyme Q Biosynthesis: From Inhibition to Bypass of Coenzyme Q Deficiency
Fabien Pierrel
Article dans une revue
hal-01583835
v1
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The COQ2 genotype predicts the severity of coenzyme Q 10 deficiency
Maria Andrea Desbats
,
Valeria Morbidoni
,
Micol Silic-Benussi
,
Mara Doimo
,
Vincenzo Ciminale
et al.
Article dans une revue
hal-01635280
v1
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The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ
Laurent Loiseau
,
Cameron Fyfe
,
Laurent Aussel
,
Mahmoud Hajj Chehade
,
Sara B. Hernández
et al.
Article dans une revue
hal-01615493
v1
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Coenzyme Q Biosynthesis: Evidence for a Substrate Access Channel in the FAD-Dependent Monooxygenase Coq6
Alexandre Ismail
,
Vincent Leroux
,
Myriam Smadja
,
Lucie Gonzalez
,
Murielle Lombard
et al.
Article dans une revue
hal-01424489
v1
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Evolution of Ubiquinone Biosynthesis: Multiple Proteobacterial Enzymes with Various Regioselectivities To Catalyze Three Contiguous Aromatic Hydroxylation Reactions
Ludovic Pelosi
,
Anne-Lise Ducluzeau
,
Laurent Loiseau
,
Frédéric Barras
,
Dominique Schneider
et al.
Article dans une revue
hal-01424513
v1
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Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity
Jonathan a. Stefely
,
Floriana Licitra
,
Leila Laredj
,
Andrew g. Reidenbach
,
Zachary a. Kemmerer
et al.
Article dans une revue
hal-01424495
v1
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Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast
Laurie-Anne Payet
,
Mélanie Leroux
,
John C. Willison
,
Akio Kihara
,
Ludovic Pelosi
et al.
Article dans une revue
hal-01424510
v1
|
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Demethylmenaquinol is a substrate of Escherichia coli nitrate reductase A (NarGHI) and forms a stable semiquinone intermediate at the NarGHI quinol oxidation site
Julia Rendon
,
Eric Pilet
,
Zeinab Fahs
,
Farida Seduk
,
Léa Sylvi
et al.
Article dans une revue
hal-01429032
v1
|
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Coq6 Is Responsible for the C4-deamination Reaction in Coenzyme Q Biosynthesis in Saccharomyces cerevisiae *
Mohammad Ozeir
,
Ludovic Pelosi
,
Alexandre Ismail
,
Caroline Mellot-Draznieks
,
Marc Fontecave
et al.
Article dans une revue
hal-01424487
v1
|
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ubiJ, a New Gene Required for Aerobic Growth and Proliferation in Macrophage, Is Involved in Coenzyme Q Biosynthesis in Escherichia coli and Salmonella enterica Serovar Typhimurium.
Laurent Aussel
,
Laurent Loiseau
,
Mahmoud Hajj Chehade
,
Bérengère Pocachard
,
Marc Fontecave
et al.
Article dans une revue
hal-00917119
v1
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Biosynthesis and physiology of coenzyme Q in bacteria.
Laurent Aussel
,
Fabien Pierrel
,
Laurent Loiseau
,
Murielle Lombard
,
Marc Fontecave
et al.
Article dans une revue
hal-01077983
v1
|
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Three conserved histidyl residues contribute to mitochondrial iron transport through mitoferrins.
Xavier Brazzolotto
,
Fabien Pierrel
,
Ludovic Pelosi
Article dans une revue
hal-00961552
v1
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A new gene involved in coenzyme Q biosynthesis in Escherichia coli: UbiI functions in aerobic C5-hydroxylation
Mahmoud Hajj Chehade
,
Laurent Loiseau
,
Murielle Lombard
,
Ludovic Pecqueur
,
Alexandre Ismail
et al.
Article dans une revue
hal-00904907
v1
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Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency.
Mara Doimo
,
Eva Trevisson
,
Rannar Airik
,
Marc Bergdoll
,
Carlos Santos-Ocaña
et al.
Article dans une revue
hal-00904926
v1
|
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In vivo accumulation of coenzyme Q biosynthetic intermediates and aminated analogs in the yeast Saccharomyces cerevisiae
Mohammad Ozeir Ozeir
,
Letian X. Xie
,
Mahmoud Hajj Chehade
,
Jeniffer Y. Tang
,
Sylvie-Kieffer Jacquinod
et al.
Article dans une revue
hal-01236935
v1
|
|
Overexpression of the Coq8 kinase in Saccharomyces cerevisiae coq null mutants allows for accumulation of diagnostic intermediates of the coenzyme Q6 biosynthetic pathway.
Letian X Xie
,
Mohammad Ozeir
,
Jeniffer y Tang
,
Jia y Chen
,
Sylvie-Kieffer Jaquinod
et al.
Article dans une revue
hal-00904902
v1
|
|
Coenzyme q biosynthesis: coq6 is required for the c5-hydroxylation reaction and substrate analogs rescue coq6 deficiency.
Mohammad Ozeir
,
Ulrich Mühlenhoff
,
Holger Webert
,
Roland Lill
,
Marc Fontecave
et al.
Article dans une revue
hal-00630764
v1
|
|
Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis.
Fabien Pierrel
,
Olivier Hamelin
,
Thierry Douki
,
Sylvie Kieffer-Jaquinod
,
Ulrich Mühlenhoff
et al.
Article dans une revue
hal-00497916
v1
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|
The role of Coa2 in hemylation of yeast Cox1 revealed by its genetic interaction with Cox10.
Megan Bestwick
,
Oleh Khalimonchuk
,
Fabien Pierrel
,
Dennis R Winge
Article dans une revue
hal-00497920
v1
|
|
Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster.
Ulrich Mühlenhoff
,
Sabine Molik
,
José R Godoy
,
Marta A Uzarska
,
Nadine Richter
et al.
Article dans une revue
hal-00630763
v1
|
|
Isolated cytochrome c oxidase deficiency in G93A SOD1 mice overexpressing CCS protein.
Marjatta Son
,
Scot C Leary
,
Nadine Romain
,
Fabien Pierrel
,
Dennis R Winge
et al.
Article dans une revue
hal-00376153
v1
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|
Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae.
Oleh Khalimonchuk
,
Kevin Rigby
,
Megan Bestwick
,
Fabien Pierrel
,
Paul A Cobine
et al.
Article dans une revue
hal-00375432
v1
|
|
Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1.
Fabien Pierrel
,
Oleh Khalimonchuk
,
Paul A Cobine
,
Megan Bestwick
,
Dennis R Winge
Article dans une revue
hal-00375430
v1
|
|
Metal Ion availability in mitochondria.
Fabien Pierrel
,
Paul A Cobine
,
Dennis R Winge
Article dans une revue
hal-00375433
v1
|
|
Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.
Fabien Pierrel
,
Megan L Bestwick
,
Paul A Cobine
,
Oleh Khalimonchuk
,
Julia A Cricco
et al.
Article dans une revue
hal-00374057
v1
|
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tRNA-modifying MiaE protein from Salmonella typhimurium is a nonheme diiron monooxygenase.
Carole Mathevon
,
Fabien Pierrel
,
Jean-Louis Oddou
,
Ricardo Garcia-Serres
,
Geneviève Blondin
et al.
Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (33), pp.13295-300. ⟨10.1073/pnas.0704338104⟩
Article dans une revue
hal-01069738
v1
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MiaB, a bifunctional radical-S-adenosylmethionine enzyme involved in the thiolation and methylation of tRNA, contains two essential [4Fe-4S] clusters.
Heather L. Hernandez
,
Fabien Pierrel
,
Eric Elleingand
,
Ricardo Garcia-Serres
,
Boi Hanh Huynh
et al.
Biochemistry, 2007, 46, pp.5140-5147
Article dans une revue
hal-00377635
v1
|
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The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding.
Paul A Cobine
,
Fabien Pierrel
,
Scot C Leary
,
Florin Sasarman
,
Yih-Chern Horng
et al.
Article dans une revue
hal-00376137
v1
|
|
Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase.
Paul A Cobine
,
Fabien Pierrel
,
Megan L Bestwick
,
Dennis R Winge
Article dans une revue
hal-00376121
v1
|
|
Copper trafficking to the mitochondrion and assembly of copper metalloenzymes.
Paul A Cobine
,
Fabien Pierrel
,
Dennis R Winge
Article dans une revue
istex
hal-00376149
v1
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