Fabrice Pagniez Maitre de Conférences

Publications

Article dans une revue (39)

Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1,2- a ]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy Lhana Tisseur,Cédric Logé,Sandrine Cojean,Khadidiatou Gassama,Lilian Karcheret al. RSC Medicinal Chemistry, 2025, 16, pp.3746-3763. ⟨10.1039/d5md00257e⟩ Article dans une revue hal-05173262v1
Synthesis and Biological Evaluation of Itraconazole Derivatives: Design in an Old Scaffold Shuai Zhong,Apollonia Kalamatianou,Gonzalo Scalese,Cillian O’beirne,Marta Redradoet al. Inorganic Chemistry, 2025, 64 (31), pp.16192-16203. ⟨10.1021/acs.inorgchem.5c02730⟩ Article dans une revue hal-05211856v1
Investigating the C2 Modulation of the Imidazo[1,2‐ a ]pyrazine‐Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition Lhana Tisseur,Sandrine Cojean,Khadidiatou Gassama,Cédric Logé,Fabrice Pagniezet al. ChemMedChem, 2025, 20 (6), pp.e202400862. ⟨10.1002/cmdc.202400862⟩ Article dans une revue hal-05181232v1
Chemical Composition, Antifungal, Antioxidant, and Hemolytic Activities of Moroccan Thymus capitatus Essential Oil Amina Amakran,Meriem Hamoudane,Fabrice Pagniez,Ahmed Lamarti,Carine Picotet al. Chemistry and Biodiversity, 2024, 21 (9), pp.e202300563. ⟨10.1002/cbdv.202300563⟩ Article dans une revue hal-04805121v1
Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry Yan Lin,Hyeim Jung,Christina Bulman,James Ng,Robin Vincket al. Journal of Medicinal Chemistry, 2023, 66 (23), ⟨10.1021/acs.jmedchem.3c01333⟩ Article dans une revue hal-04311470v1
CRISPR-Cas9 approach confirms Calcineurin-responsive zinc finger 1 (Crz1) transcription factor as a promising therapeutic target in echinocandin-resistant Candida glabrata Andres Ceballos-Garzon,Elvira Roman,Jesús Pla,Fabrice Pagniez,Daniela Amadoet al. PLoS ONE, 2022, 17 (3), pp.e0265777. ⟨10.1371/journal.pone.0265777⟩ Article dans une revue hal-04753979v1
Impact of TR34/L98H, TR46/Y121F/T289A and TR53 Alterations in Azole-Resistant Aspergillus fumigatus on Sterol Composition and Modifications after In Vitro Exposure to Itraconazole and Voriconazole Rose-Anne Lavergne,Marjorie Albassier,Jean-Benoît Hardouin,Carlos Alvarez-Moreno,Fabrice Pagniezet al. Microorganisms, 2022, 10 (1), pp.104. ⟨10.3390/microorganisms10010104⟩ Article dans une revue hal-03778408v1
In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition Marc-Antoine Bazin,Sandrine Cojean,Fabrice Pagniez,Guillaume Bernadat,Christian Cavéet al. European Journal of Medicinal Chemistry, 2021, 210, pp.112956. ⟨10.1016/j.ejmech.2020.112956⟩ Article dans une revue pasteur-03108849v1
Antimicrobial and antileishmanial activities of extracts and some constituents from the leaves of Solanum chrysotrichum Schldl Guillermo Núñez-Mojica,Verónica Rivas-Galindo,Elvira Garza-González,Luis Miranda,Adriana Romo-Pérezet al. Medicinal Chemistry Research, 2020, 30 (1), pp.152-162. ⟨10.1007/s00044-020-02648-8⟩ Article dans une revue hal-04721673v1
New azole antifungals with a fused triazinone scaffold David Montoir,Rémi Guillon,Sophie Gazzola,Isabelle Ourliac-Garnier,Kossi Efouako Soklouet al. European Journal of Medicinal Chemistry, 2020, 189, pp.112082. ⟨10.1016/j.ejmech.2020.112082⟩ Article dans une revue hal-03412473v1
Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols Nicolas Lebouvier,Fabrice Pagniez,Young Min Na,Da Shi,Patricia Pinsonet al. Pharmaceuticals, 2020, 13 (8), ⟨10.3390/ph13080186⟩ Article dans une revue hal-03389414v1
Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols Nicolas Lebouvier,Fabrice Pagniez,Young Min Na,Da Shi,Patricia Pinsonet al. Pharmaceuticals, 2020, 13 (8), 186 (32 p.). ⟨10.3390/ph13080186⟩ Article dans une revue hal-02913479v2
Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent Fabrice Pagniez,Nicolas Lebouvier,Young Min Na,Isabelle Ourliac-Garnier,Carine Picotet al. Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.398-403. ⟨10.1080/14756366.2019.1705292⟩ Article dans une revue hal-02455791v2
Econazole imprinted textiles with antifungal activity Mirza Akram Hossain,Fabrice Pagniez,Aicha Benhaddou,Martine Raymond,Karine Thébergeet al. European Journal of Pharmaceutics and Biopharmaceutics, 2016, ⟨10.1016/j.ejpb.2016.02.003⟩ Article dans une revue hal-02512446v1
Identification and Biological Activities of Long-Chain Peptaibols Produced by a Marine-Derived Strain of Trichoderma longibrachiatum Mustapha Mohamed-Benkada,Yves-François Pouchus,Philippe Vérité,Fabrice Pagniez,Nathalie Caroffet al. Chemistry and Biodiversity, 2016, 13 (5), pp.521-530. ⟨10.1002/cbdv.201500159⟩ Article dans une revue istex hal-02469759v1
Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines Pascal Marchand,Marc-Antoine Bazin,Fabrice Pagniez,Guillaume Rivière,Lizeth Boderoet al. European Journal of Medicinal Chemistry, 2015, 103, pp.381-395. ⟨10.1016/j.ejmech.2015.09.002⟩ Article dans une revue istex hal-03216056v1
Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents – Part III Luisa Ronga,Marco del Favero,Anita Cohen,Claire Soum,Patrice Le Papeet al. European Journal of Medicinal Chemistry, 2014, 81, pp.378-393. ⟨10.1016/j.ejmech.2014.05.037⟩ Article dans une revue istex hal-03800819v1
Discovery of a Novel Broad-Spectrum Antifungal Agent Derived from Albaconazole Rémi Guillon,Fabrice Pagniez,Carine Picot,Damien Hédou,Alain Tonnerreet al. ACS Medicinal Chemistry Letters, 2013, 4 (2), pp.288-292. ⟨10.1021/ml300429p⟩ Article dans une revue hal-01015468v1
Anti-AGEs and antiparasitic activity of an original prenylated isoflavonoid and flavanones isolated from Derris ferruginea Sylvie Morel,Jean-Jacques Helesbeux,Denis Séraphin,Séverine Derbré,Julia Gattoet al. Phytochemistry Letters, 2013, 6 (3), pp.498-503. ⟨10.1016/j.phytol.2013.06.002⟩ Article dans une revue hal-05519307v1
Deciphering azole resistance mechanisms with a focus on transcription factor-encoding genes TAC1, MRR1 and UPC2 in a set of fluconazole-resistant clinical isolates of Candida albicans Florent Morio,Fabrice Pagniez,Myriam Besse,Françoise Gay-Andrieu,Michel Miegevilleet al. International Journal of Antimicrobial Agents, 2013, 42 (5), pp.410-415. ⟨10.1016/j.ijantimicag.2013.07.013⟩ Article dans une revue istex hal-03827331v1
Anti-AGEs and antiparasitic activity of an original prenylated isoflavonoid and flavanones isolated from Derris ferruginea Sylvie Morel,Jean-Jacques Helesbeux,Denis Séraphin,Séverine Derbré,Julia Gattoet al. Phytochemistry Letters, 2013, 6 (3), pp.498-503. ⟨10.1016/j.phytol.2013.06.002⟩ Article dans une revue hal-00911058v1
Preparative Isolation, Fast Centrifugal Partition Chromatography Purification and Biological Activity of Cajaflavanone from Derris ferruginea Stems Sylvie Morel,Anne Landreau,van Hung Nguyen,Séverine Derbré,Philippe Grellieret al. Phytochemical Analysis, 2012, 23 (2), pp.152-158. ⟨10.1002/pca.1336⟩ Article dans une revue istex mnhn-02047397v1
Amino acid substitutions in the Candida albicans sterol 5,6-desaturase (Erg3p) confer azole resistance: characterization of two novel mutants with impaired virulence Florent Morio,Fabrice Pagniez,C. Lacroix,Michel Miegeville,Patrice Le Pape Journal of Antimicrobial Chemotherapy, 2012, 67 (9), pp.2131-2138. ⟨10.1093/jac/dks186⟩ Article dans une revue hal-03822982v1
Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents Sophie Marhadour,Pascal Marchand,Fabrice Pagniez,Marc-Antoine Bazin,Carine Picotet al. European Journal of Medicinal Chemistry, 2012, 58, pp.543-556. ⟨10.1016/j.ejmech.2012.10.048⟩ Article dans une revue istex hal-03882013v1
Design, Synthesis, and in vitro Antifungal Activity of 1-[(4-Substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols Rémi Guillon,Fabrice Pagniez,Francis Giraud,Damien Crépin,Carine Picotet al. ChemMedChem, 2011, 6 (5), pp.816 - 825. ⟨10.1002/cmdc.201000530⟩ Article dans une revue istex hal-01689176v1
Isoquinolines from the Roots of Thalictrum flavum L. and Their Evaluation as Antiparasitic Compounds Jacqueline Ropivia,Séverine Derbré,Caroline Rouger,Fabrice Pagniez,Patrice Le Papeet al. Molecules, 2010, 15 (9), pp.6476-6484. ⟨10.3390/molecules15096476⟩ Article dans une revue hal-03247823v1
Synthesis and in vitro antifungal evaluation of 2-(2,4-difluorophenyl)-1-[(1 H -indol-3-ylmethyl)methylamino]-3-(1 H -1,2,4-triazol-1-yl)propan-2-ols Rémi Guillon,Cédric Logé,Fabrice Pagniez,Véronique Ferchaud-Roucher,Muriel Dufloset al. Journal of Enzyme Inhibition and Medicinal Chemistry, 2010, 26 (2), pp.261-269. ⟨10.3109/14756366.2010.503607⟩ Article dans une revue hal-04792103v1
Synthesis and structure–activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents Francis Giraud,Rémi Guillon,Cédric Logé,Fabrice Pagniez,Carine Picotet al. Bioorganic and Medicinal Chemistry Letters, 2009, 19 (2), pp.301 - 304. ⟨10.1016/j.bmcl.2008.11.101⟩ Article dans une revue istex hal-01689192v1
Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II Francis Giraud,Cédric Logé,Fabrice Pagniez,Damien Crépin,Sophie Barreset al. Journal of Enzyme Inhibition and Medicinal Chemistry, 2009, 24 (5), pp.1067 - 1075. ⟨10.1080/14756360802610795⟩ Article dans une revue hal-01689191v1
Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols Rémi Guillon,Francis Giraud,Cédric Logé,Marc Le Borgne,Carine Picotet al. Bioorganic and Medicinal Chemistry Letters, 2009, 19 (20), pp.5833 - 5836. ⟨10.1016/j.bmcl.2009.08.089⟩ Article dans une revue istex hal-01689189v1
Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents Francis Giraud,Cédric Logé,Fabrice Pagniez,Damien Crépin,Patrice Le Papeet al. Bioorganic and Medicinal Chemistry Letters, 2008, 18 (6), pp.1820 - 1824. ⟨10.1016/j.bmcl.2008.02.027⟩ Article dans une revue istex hal-01689196v1
Antileishmanial polyphenols from Garcinia vieillardii. Anne-Emmanuelle Hay,Joumaa Merza,Anne Landreau,Marc Litaudon,Fabrice Pagniezet al. Fitoterapia, 2008, 79 (1), pp.42-46. ⟨10.1016/j.fitote.2007.07.005⟩ Article dans une revue istex hal-00294806v1
Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety Nicolas Lebouvier,Fabrice Pagniez,Muriel Duflos,Patrice Le Pape,Young Min Naet al. Bioorganic and Medicinal Chemistry Letters, 2007, 17 (13), pp.3686 - 3689. ⟨10.1016/j.bmcl.2007.04.038⟩ Article dans une revue istex hal-01689197v1
A 3D-QSAR CoMSIA study on 3-azolylmethylindoles as anti-leishmanial agents Francis Giraud,Cédric Logé,Marc Le Borgne,Fabrice Pagniez,Young Min Naet al. SAR and QSAR in Environmental Research, 2006, 17 (3), pp.299 - 309. ⟨10.1080/10659360600787494⟩ Article dans une revue hal-01689291v1
Antileishmanial activities and mechanisms of action of indole-based azoles Fabrice Pagniez,Hiam Abdala-Valencia,Pascal Marchand,Marc Le Borgne,Guillaume Le Bautet al. Journal of Enzyme Inhibition and Medicinal Chemistry, 2006, 21 (3), pp.277 - 283. ⟨10.1080/14756360600700517⟩ Article dans une revue hal-01689215v1
Synthesis and Antileishmanial Activity of 3-Imidazolylalkylindoles. Part I Young Min Na,Nicolas Lebouvier,Marc Le Borgne,Fabrice Pagniez,Nidia Alvarezet al. Journal of Enzyme Inhibition and Medicinal Chemistry, 2004, 19 (6), pp.451 - 457. ⟨10.1080/14756360412331280509⟩ Article dans une revue hal-01689240v1
Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives Young Min Na,Marc Le Borgne,Fabrice Pagniez,Guillaume Le Baut,Patrice Le Pape European Journal of Medicinal Chemistry, 2003, 38 (1), pp.75 - 87. ⟨10.1016/S0223-5234(02)00005-3⟩ Article dans une revue istex hal-01689264v1
Synthesis and Antileishmanial Activity of 3-(α-Azolylbenzyl)indoles Pascal Marchand,Marc Le Borgne,Young Min Na,Fabrice Pagniez,Hiam Abdalaet al. Journal of Enzyme Inhibition and Medicinal Chemistry, 2002, 17 (6), pp.353 - 358. ⟨10.1080/1475636021000005613⟩ Article dans une revue hal-01689261v1
In Vitro Activity of a New Antifungal Azolyl-substituted Indole Against Aspergillus fumigatus Fabrice Pagniez,Marc Le Borgne,Pascal Marchand,Young Min Na,Guillaume Le Bautet al. Journal of Enzyme Inhibition and Medicinal Chemistry, 2002, 17 (6), pp.425 - 429. ⟨10.1080/1475636021000005686⟩ Article dans une revue hal-01689259v1

Communication dans un congrès (3)

Modifying positions 2 or 8 of the imidazo[1,2-a]pyrazine lead compound CTN1122 affects its antileishmanial activity, L-CK1.2 kinase inhibition, and safety profile Lhana Tisseur,Marc-Antoine Bazin,Sandrine Cojean,Fabrice Pagniez,Cédric Logéet al. GP2A 2024, Aug 2024, Coimbra, Portugal Communication dans un congrès hal-04708945v1
La conception d'une formation comme environnement capacitant Anne-Celine Grolleau,Fabrice Pagniez,Arnold Magdelaine QPES Questions de pédagogie dans l’enseignement supérieur, CESI; Université de La Rochelle, Jan 2022, En ligne, France Communication dans un congrès hal-04195839v1
Triazole-indole hybrid molecules as antifungal agents: Design, synthesis and biological activity, and beyond Nicolas Lebouvier,Fabrice Pagniez,Young Min Na,Angélique Mularoni,Marie Brossieret al. 7th International Electronic Conference on Medicinal Chemistry, Nov 2021, Sciforum.net, France. pp.11577, ⟨10.3390/ECMC2021-11577⟩ Communication dans un congrès hal-03556313v1