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Farida Djouad



- **EDUCATION** **2012** “Habilitation à diriger des recherches” (HDR), Université de Montpellier, France **2006** Ph.D. Biology and Health, University of Montpellier, France. **2002** Master’s Degree (DEA) in Biology and Health, University of Montpellier, France **2001** Master’s Degree (maîtrise), in Biochemistry, University of Montpellier, France - **POSITIONS HELD** **2013-** Staff Scientist (Chargée de Recherche, CR1 INSERM), Group Leader Institute for Regenerative Medicine & Biotherapy (IRMB), Montpellier, France **2009-** Staff Scientist (Chargée de Recherche, CR2 INSERM) Institute of Neurosciences of Montpellier (INM), Montpellier, France **2006-2008** Post-doctoral fellow in the laboratory of Rocky Tuan, NIAMS, NIH, Bethesda, USA


PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties

Sarah Bahraoui , Gautier Tejedor , Anne-Laure Mausset-Bonnefont , François Autelitano , Audrey Barthelaix
Current Stem Cell Research & Therapy, 2024, 15 (1), pp.70. ⟨10.1186/s13287-024-03650-2⟩
Journal articles inserm-04520310v1
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Transfer of mesenchymal stem cell mitochondria to CD4+ T cells contributes to repress Th1 differentiation by downregulating T-bet expression

Waseem Akhter , Jean Nakhle , Loïc Vaillant , Geneviève Garcin , Cécile Le Saout
Stem Cell Research and Therapy, 2023, 14 (1), pp.12. ⟨10.1186/s13287-022-03219-x⟩
Journal articles hal-03956467v1
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PPARβ/δ-Interfering Peptide Enhanced Mesenchymal Stromal Cell Immunoregulatory Properties

Gautier Tejedor , Prisca Boisguérin , Éric Vivès , Christian Jorgensen , Jérôme Guicheux
Stem Cells International, 2022, 2022, pp.1-12. ⟨10.1155/2022/5494749⟩
Journal articles hal-03912708v1
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PPARβ/δ priming enhances the anti-apoptotic and therapeutic properties of mesenchymal stromal cells in myocardial ischemia–reperfusion injury

Charlotte Sarre , Rafael Contreras-Lopez , Nitirut Nernpermpisooth , Christian Barrère , Sarah Bahraoui
Current Stem Cell Research & Therapy, 2022, 13 (1), pp.167. ⟨10.1186/s13287-022-02840-0⟩
Journal articles hal-03653227v1
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PPARβ/δ Is Required for Mesenchymal Stem Cell Cardioprotective Effects Independently of Their Anti-inflammatory Properties in Myocardial Ischemia-Reperfusion Injury

Nitirut Nernpermpisooth , Charlotte Sarre , Christian Barrere , Rafaël Contreras , Patricia Luz-Crawford
Frontiers in Cardiovascular Medicine, 2021, 8, pp.681002. ⟨10.3389/fcvm.2021.681002⟩
Journal articles hal-03644844v1
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Pyrroline-5-Carboxylate Reductase 1 Directs the Cartilage Protective and Regenerative Potential of Murphy Roths Large Mouse Mesenchymal Stem Cells

Gautier Tejedor , Rafael Contreras-Lopez , Audrey Barthelaix , Maxime Ruiz , Danièle Noël
Frontiers in Cell and Developmental Biology, 2021, 9, pp.604756. ⟨10.3389/fcell.2021.604756⟩
Journal articles hal-03653004v1
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Pro-regenerative Dialogue Between Macrophages and Mesenchymal Stem/Stromal Cells in Osteoarthritis

Candice Bohaud , Rafael Contreras-Lopez , Jholy de La Cruz , Claudia Terraza-Aguirre , Mingxing Wei
Frontiers in Cell and Developmental Biology, 2021, 9, pp.718938. ⟨10.3389/fcell.2021.718938⟩
Journal articles hal-03646573v1
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MANF Produced by MRL Mouse-Derived Mesenchymal Stem Cells Is Pro-regenerative and Protects From Osteoarthritis

Gautier Tejedor , Patricia Luz-Crawford , Audrey Barthelaix , Karine Toupet , Sébastien Roudières
Frontiers in Cell and Developmental Biology, 2021, 9, pp.579951. ⟨10.3389/fcell.2021.579951⟩
Journal articles hal-03670111v1
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NRG1/ErbB signalling controls the dialogue between macrophages and neural crest-derived cells during zebrafish fin regeneration

Béryl Laplace-Builhé , Audrey Barthelaix , Said Assou , Candice Bohaud , Marine Pratlong
Nature Communications, 2021, 12 (1), pp.6336. ⟨10.1038/s41467-021-26422-5⟩
Journal articles hal-03646943v1
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Long non-coding RNA exploration for mesenchymal stem cell characterisation

Sébastien Riquier , Marc Mathieu , Chloé Bessiere , Anthony Boureux , Florence Rufflé
BMC Genomics, 2021, 22 (1), pp.412. ⟨10.1186/s12864-020-07289-0⟩
Journal articles inserm-03251471v1
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The Role of Macrophages During Mammalian Tissue Remodeling and Regeneration Under Infectious and Non-Infectious Conditions

Candice Bohaud , Matt D Johansen , Christian Jorgensen , Laurent Kremer , Natacha Ipseiz
Frontiers in Immunology, 2021, 12, pp.707856. ⟨10.3389/fimmu.2021.707856⟩
Journal articles inserm-03381916v1
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The Role of Macrophages During Zebrafish Injury and Tissue Regeneration Under Infectious and Non-Infectious Conditions

Candice Bohaud , Matt D Johansen , Christian Jorgensen , Natacha Ipseiz , Laurent Kremer
Frontiers in Immunology, 2021, 12, pp.707824. ⟨10.3389/fimmu.2021.707824⟩
Journal articles inserm-03381914v1
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Mechanisms behind the Immunoregulatory Dialogue between Mesenchymal Stem Cells and Th17 Cells

Claudia Terraza-Aguirre , Mauricio Campos-Mora , Roberto Elizondo-Vega , Rafael Contreras-López , Patricia Luz-Crawford
Cells, 2020, 9 (7), pp.1660. ⟨10.3390/cells9071660⟩
Journal articles hal-03594110v1
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PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass

Dorothea I H Müller , Cornelia Stoll , Katrin Palumbo-Zerr , Christina Böhm , Brenda Krishnacoumar
Scientific Reports, 2020, 10 (1), pp.8428. ⟨10.1038/s41598-020-65305-5⟩
Journal articles inserm-02869506v1
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Whole embryo culture, transcriptomics and RNA interference identify TBX1 and FGF11 as novel regulators of limb development in the mouse

Gautier Tejedor , Béryl Laplace-Builhé , Patricia Luz-Crawford , Said Assou , Audrey Barthelaix
Scientific Reports, 2020, 10 (1), pp.3597. ⟨10.1038/s41598-020-60217-w⟩
Journal articles inserm-02498306v1

POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4

Elodie Sanchez , Béryl Laplace-Builhé , Frédéric Tran Mau-Them , Eric Richard , Alice Goldenberg
Genetics in Medicine, 2020, 22 (3), pp.547-556. ⟨10.1038/s41436-019-0669-9⟩
Journal articles hal-02549940v1
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Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE

Mónica Kurte , Ana María Vega-Letter , Patricia Luz-Crawford , Farida Djouad , Danièle Noël
Current Stem Cell Research & Therapy, 2020, 11, pp.416. ⟨10.1186/s13287-020-01840-2⟩
Journal articles hal-02961469v1
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Pro‐resolving mediator protectin D1 promotes epimorphic regeneration by controlling immune cell function in vertebrates

Mai Nguyen-Chi , Patricia Luz-Crawford , Laurence Balas , Tamara Sipka , Rafael Contreras-López
British Journal of Pharmacology, 2020, 177 (17), pp.4055-4073. ⟨10.1111/bph.15156⟩
Journal articles hal-02993375v1
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PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties

Rafael A Contreras-Lopez , Roberto Elizondo-Vega , Maria J Torres , Ana M Vega-Letter , Noymar Luque-Campos
Scientific Reports, 2020, 10 (1), pp.11423. ⟨10.1038/s41598-020-68347-x⟩
Journal articles inserm-02925972v1
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Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer

Patricia Luz-Crawford , Javier Hernandez , Farida Djouad , Noymar Luque-Campos , Andrès Caicedo
Current Stem Cell Research & Therapy, 2019, 10 (1), pp.232. ⟨10.1186/s13287-019-1307-9⟩
Journal articles inserm-02376241v1
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Where to Stand with Stromal Cells and Chronic Synovitis in Rheumatoid Arthritis?

Jean-Marc Brondello , Farida Djouad , Christian Jorgensen
Cells, 2019, 8 (10), pp.1257. ⟨10.3390/cells8101257⟩
Journal articles hal-02555388v1
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Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo

Vincent Hyenne , Shima Ghoroghi , Mayeul Collot , Joanna Bons , Gautier Follain
Developmental Cell, 2019, 48 (4), pp.554-572.e7. ⟨10.1016/j.devcel.2019.01.014⟩
Journal articles hal-02274251v1

Comparative regenerative properties of mesenchymal stem cells isolated from MRL (Murphy Roths Large) versus C57Bl6 mice

C. Sarre , G. Tejedor , P. Gonzalez , S. Bahraoui , Christian Barrère
Archives of Cardiovascular Diseases Supplements, 2019, 11 (2), pp.244-245. ⟨10.1016/j.acvdsp.2019.02.137⟩
Journal articles hal-02404686v1
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Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression by Controlling Memory T Cell Response

Noymar Luque-Campos , Rafael Contreras-López , María Jose Paredes-Martínez , Maria Jose Torres , Sarah Bahraoui
Frontiers in Immunology, 2019, 10, pp.Front. Immunol. 10:798. ⟨10.3389/fimmu.2019.00798⟩
Journal articles hal-03076689v1
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Secreted α-Klotho maintains cartilage tissue homeostasis by repressing NOS2 and ZIP8-MMP13 catabolic axis.

Paul Chuchana , Anne-Laure Mausset-Bonnefont , Marc Mathieu , Francisco Espinoza , Marisa Teigell
Aging, 2018, 10 (6), pp.1442-1453. ⟨10.18632/aging.101481⟩
Journal articles hal-01834060v1
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Gilz-Activin A as a Novel Signaling Axis Orchestrating Mesenchymal Stem Cell and Th17 Cell Interplay

Patricia Luz-Crawford , Gabriel Espinosa-Carrasco , Natacha Ipseiz , Rafael Contreras , Gautier Tejedor
Theranostics, 2018, 8 (3), pp.846 - 859. ⟨10.7150/thno.21793⟩
Journal articles hal-01834084v1
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IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis

Monica Kurte , Patricia Luz-Crawford , Ana María Vega-Letter , Rafael Contreras , Gautier Tejedor
Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.00802⟩
Journal articles hal-01833410v1

Mesenchymal Stem Cells Direct the Immunological Fate of Macrophages.

Patricia Luz-Crawford , Christian Jorgensen , Farida Djouad
Results and Problems in Cell Differentiation, 2017, pp.61-72. ⟨10.1007/978-3-319-54090-0_4⟩
Journal articles hal-01834124v1
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TNF signaling and macrophages govern fin regeneration in zebrafish larvae

Mai Nguyen-Chi , Béryl Laplace-Builhé , Jana Travnickova , Patricia Luz-Crawford , Gautier Tejedor
Cell Death and Disease, 2017, 8, pp.e2979. ⟨10.1038/cddis.2017.374⟩
Journal articles hal-02086729v1

PPARβ/δ: A master regulator of mesenchymal stem cell functions

Farida Djouad , Natacha Ipseiz , Patricia Luz-Crawford , Carina Scholtysek , Gerhard Krönke
Biochimie, 2017, 136, pp.55 - 58. ⟨10.1016/j.biochi.2016.11.011⟩
Journal articles hal-01798137v1

The immunosuppressive signature of menstrual blood mesenchymal stem cells entails opposite effects on experimental arthritis and graft versus host diseases

Patricia Luz-Crawford , María Torres , Danièle Noël , Ainoa Fernandez , Karine Toupet
STEM CELLS, 2016, 34 (2), pp.456 - 469. ⟨10.1002/stem.2244⟩
Journal articles hal-01834145v1
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Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression

R. Contreras , F. Figueroa , Farida Djouad , P. Luz-Crawford
Stem Cells International, 2016, 2016, pp.3162743. ⟨10.1155/2016/3162743⟩
Journal articles hal-01834064v1

PPARβ/δ directs the therapeutic potential of mesenchymal stem cells in arthritis

C Luz-Crawford , N Ipseiz , G Espinosa-Carrasco , C Caicedo , G Tejedor
Annals of the Rheumatic Diseases, 2016, 75 (12), pp.2166 - 2174. ⟨10.1136/annrheumdis-2015-208696⟩
Journal articles hal-01834105v1
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Deciphering the complexity of macrophage biology and function with the zebrafish model

Nguyen-Chi Mai , Laplace-Builhé Béryl , Jorgensen Christian , Farida Djouad
Macrophage, 2016, 3, ⟨10.14800/Macrophage.1260⟩
Journal articles hal-02097516v1

Mesenchymal Stem Cell-Derived Interleukin 1 Receptor Antagonist Promotes Macrophage Polarization and Inhibits B Cell Differentiation

Patricia Luz-Crawford , Farida Djouad , Karine Toupet , Claire Bony , Marcella Franquesa
STEM CELLS, 2016, 34 (2), pp.483 - 492. ⟨10.1002/stem.2254⟩
Journal articles hal-01834077v1

Glucocorticoid-Induced Leucine Zipper Governs the Therapeutic Potential of Mesenchymal Stem Cells by Inducing a Switch From Pathogenic to Regulatory Th17 Cells in a Mouse Model of Collagen-Induced Arthritis

P. Luz-Crawford , G. Tejedor , Anne-Laure Mausset-Bonnefont , E. Beaulieu , F. Morand
Arthritis & rheumatology, 2015, 67 (6), pp.1514 - 1524. ⟨10.1002/art.39069⟩
Journal articles hal-01834130v1
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Identification of polarized macrophage subsets in zebrafish

Mai Nguyen-Chi , Béryl Laplace-Builhé , Jana Travnickova , Patricia Luz-Crawford , Gautier Tejedor
Journal articles hal-01834168v2
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Promyelocytic leukemia zinc-finger induction signs mesenchymal stem cell commitment: identification of a key marker for stemness maintenance?

Farida Djouad , Gautier Tejedor , Karine Toupet , Marie Maumus , Claire Bony
Stem Cell Research and Therapy, 2014, 5 (1), pp.27. ⟨10.1186/scrt416⟩
Journal articles inserm-00976578v1
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Functional cartilage repair capacity of de-differentiated, chondrocyte- and mesenchymal stem cell-laden hydrogels in vitro

Lars Rackwitz , Farida Djouad , Sasa Janjanin , Ulrich Nöth , Rocky S. Tuan
Osteoarthritis and Cartilage, 2014, 22 (8), pp.1148-1157. ⟨10.1016/j.joca.2014.05.019⟩
Journal articles hal-03109221v1
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Involvement of Angiopoietin-like 4 in Matrix Remodeling during Chondrogenic Differentiation of Mesenchymal Stem Cells

Marc Mathieu , Mathieu Iampietro , Paul Chuchana , David Guérit , Farida Djouad
Journal of Biological Chemistry, 2014, 289 (12), pp.8402-8412. ⟨10.1074/jbc.M113.539825⟩
Journal articles hal-03116030v1
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Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells.

Patricia Luz-Crawford , Monica Kurte , Javiera Bravo-Alegría , Rafael Contreras , Estefania Nova-Lamperti
Stem Cell Research and Therapy, 2013, 4 (3), pp.65. ⟨10.1186/scrt216⟩
Journal articles inserm-00836318v1

Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue

Wesley Jackson , Thomas Lozito , Farida Djouad , Nastaran Kuhn , Leon Nesti
Journal of Cellular and Molecular Medicine, 2011, 15 (11), pp.2377 - 2388. ⟨10.1111/j.1582-4934.2010.01225.x⟩
Journal articles hal-01878048v1
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Activin A expression regulates multipotency of mesenchymal progenitor cells.

Farida Djouad , Wesley Jackson , Brent Bobick , Sasa Janjanin , Yingjie Song
Stem Cell Research and Therapy, 2010, 1 (2), pp.11. ⟨10.1186/scrt11⟩
Journal articles inserm-00622572v1

Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications

Soufiane Ghannam , Carine Bouffi , Farida Djouad , Christian Jorgensen , Danièle Noël
Current Stem Cell Research & Therapy, 2010, 1 (1), ⟨10.1186/scrt2⟩
Journal articles inserm-01878105v1

Transcriptomic Analysis Identifies Foxo3A as a Novel Transcription Factor Regulating Mesenchymal Stem Cell Chrondrogenic Differentiation

Farida Djouad , Claire Bony , François Canovas , Olivia Fromigue , Thierry Rème
Cloning and Stem Cells, 2009, 11 (3), pp.407 - 416. ⟨10.1089/clo.2009.0013⟩
Journal articles inserm-01878108v1
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Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells.

Farida Djouad , Claire Bony , Thomas Häupl , Gilles Uzé , Najiba Lahlou
Arthritis Research and Therapy, 2005, 7, pp.R1304-15. ⟨10.1186/ar1827⟩
Journal articles inserm-00089978v1

Demonstration of Immunomodulatory properties for the human MuStem cell population, a promising candidate for cell therapy of muscular dystrophies

Marine Charrier , Judith Lorant , Rafael Contreras-López , Christophe Blanquart , Blandine Lieubeau
Forum Bioregate, Dec 2018, Nantes, France
Conference papers hal-01959647v1

Protective effect of thrombospondin-4 expressing mesenchymal stem cells in osteoarthritis

M. Maumus , K. Toupet , Farida Djouad , J.-P. David , C. Jorgensen
World Congress of the Osteoarthritis-Research-Society-International (OARSI) on Osteoarthritis, Mar 2016, Amsterdam, Netherlands. ⟨10.1016/j.joca.2016.01.926⟩
Conference papers hal-01834285v1

Protective effect of thrombospondin-4 expressing mesenchymal stem cells in osteoarthritis

M Maumus , K Toupet , Farida Djouad , D David , C Jorgensen
36th European Workshop for Rheumatology Research (EWRR), Feb 2016, York, United Kingdom. pp.A56.2 - A56, ⟨10.1136/annrheumdis-2016-209124.133⟩
Conference papers hal-01834281v1

Pro-inflammatory macrophages mediated TNF-alpha signalling is required for caudal fin regenerationin zebrafish larvae

B Laplace-Builhe , Mai Nguyen-Chi , J Travnickova , C Luz-Crawford , G. Tejedor
ANNALS OF THE RHEUMATIC DISEASES, Mar 2015, London, United Kingdom. pp.A16.1 - A16, ⟨10.1136/annrheumdis-2015-207259.37⟩
Conference papers hal-01834525v1

Identification of macrophage subsets in zebrafish larvae

Mai Nguyen-Chi , B Laplace-Builhe , J Travnickova , C Luz-Crawford , G. Tejedor
ANNALS OF THE RHEUMATIC DISEASES, Mar 2015, London, United Kingdom. pp.A8.2 - A8, ⟨10.1136/annrheumdis-2015-207259.19⟩
Conference papers hal-01834463v1

PPARβ/δ expression orchestrates the immunosuppressive effect of mesenchymal stem cells via NF-κB signalling

C Luz-Crawford , N Ipseiz , C Caicedo , C Scholtysek , C Stoll
ANNALS OF THE RHEUMATIC DISEASES, Mar 2015, London, United Kingdom. pp.A91.1 - A91, ⟨10.1136/annrheumdis-2015-207259.209⟩
Conference papers hal-01834517v1
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Mesenchymal stem cells repress Th17 molecular program through the PD-1 pathway

Patricia Luz-Crawford , Daniele Noël , Fernando Figueroa , Flavio Carrión , Christian Jorgensen
7th European Workshop on Immune-Mediated Inflammatory Diseases, Nov 2012, Noordwijk aan Zee, Netherlands. pp.P16
Conference papers inserm-00758222v1