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Fernanda FONSECA

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#### **EDUCATION** **Habilitation à Diriger des Recherches (HDR).** Université de Technologie de Compiègne, 2010. Title : « Stabilization of bio functionalities trough an approach combining the understanding of mechanisms and the product-process engineering” **Ph.D. Degree** in **Biotechnology and Process Engineering**, Institut National Agronomique Paris-Grignon (AgroParisTech),**2001**. Ph.D. thesis title: "Influence of cryoprotection and freezing on the acidification activity of thermopile lactic acid bacteria: relationships between biological and thermodynamic properties." **Master Degree** in **Biotechnology and Process Engineering**, Institut National Agronomique Paris-Grignon (AgroParisTech), **1997**. M.Sc. thesis title: "Study of the freezing step on the activity of frozen lactic acid starters." Engineer** in **Chemical Engineering**, Montevideo University (Uruguay), **1996.** **SCIENTIFIC EXPERIENCE** ------------------------- **Research Director (since January 2015),** in Paris-Saclay Food and Bioproduct Engineering research unit (UMR 782 SayFood INRAE-AgroParisTech), Versailles-Grignon Centre, at the French National Institute for Agriculture, Food and Environment (INRAE), France. **Researcher Scientist** (**September 2001 – December 2014**), in the Joint Research Unit for Food Process Engineering and Microbiology (UMR 782 GMPA INRA-AgroParisTech), Versailles-Grignon Centre, Institut National de la Recherche Agronomique (INRA), France. **Main fields of expertise:**Biotechnology and process engineering: fermentation, formulation, and stabilization of bioproducts. - Bioproducts: micro-organisms, proteins, food products. - Stabilization processes: freezing and freeze-drying - Biophysical characterization of bioproducts (thermal analysis, freeze-drying microscopy, Fourier Transformed InfraRed microspectroscopy) **Research approach:** Focusing on biophysical and chemical behaviors of bioproducts during stabilization processes and by relating them to biological and functional responses, to identify and quantify the mechanisms governing the degradation and preservation of bioproducts during the stabilization processes. The ambition is also to find general principles for simplifying and rationalizing the development of newly formulated products and the stabilization process optimization, with particular attention to limiting the environmental impact.

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Publications

ioan-cristian-trelea
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Multi-objective optimization of frozen and freeze-dried Lactobacillus delbrueckii subsp. bulgaricus CFL1 production via the modification of fermentation conditions

Maria de Lourdes Tovilla Coutino , Stephanie Passot , Ioan-Cristian Trelea , Marie-Hélène Ropers , Yann Gohon
Journal of Applied Microbiology, 2023, 134 (2), pp.1-34. ⟨10.1093/jambio/lxad003⟩
Article dans une revue hal-04345553v1
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Use of 3D mathematical modelling to understand the heat transfer mechanisms during freeze-drying using high-throughput vials

Juan Patricio Buceta , Stephanie Passot , Bernadette Scutellà , Erwan Bourlés , Fernanda Fonseca
Applied Thermal Engineering, 2022, 207, pp.118099. ⟨10.1016/j.applthermaleng.2022.118099⟩
Article dans une revue hal-03562611v1
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Insights into lactic acid bacteria cryoresistance using FTIR micro-spectroscopy

Amélie Girardeau , Stephanie Passot , Julie Meneghel , Stéphanie Cenard , Pascale Lieben
Analytical and Bioanalytical Chemistry, 2022, 414 (3), pp.1425-1443. ⟨10.1007/s00216-021-03774-x⟩
Article dans une revue hal-03552585v1
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Dynamic Modeling of Carnobacterium Maltaromaticum CNCM I-3298 Growth and Metabolite Production and Model-Based Process Optimization

Cristian Puentes , Amélie Girardeau , Stephanie Passot , Fernanda Fonseca , Ioan-Cristian Trelea
Foods, 2021, 10 (8), pp.1922. ⟨10.3390/foods10081922⟩
Article dans une revue hal-03552068v1
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Heat Transfer During Freeze-Drying Using a High-throughput vial System in view of Process Scale-up to Serum vials

Juan Patricio Buceta , Ioan Trelea , Bernadette Scutellà , Erwan Bourlés , Fernanda Fonseca
Journal of Pharmaceutical Sciences, 2021, 110 (3), pp.1323-1336. ⟨10.1016/j.xphs.2020.11.029⟩
Article dans une revue hal-03117931v1
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Influence of culture conditions on the technological properties of Carnobacterium maltaromaticum CNCM I-3298 starters

Amélie Girardeau , C. Puentes , S. Keravec , P. Peteuil , Ioan-Cristian Trelea
Journal of Applied Microbiology, 2019, 126 (5), pp.1468-1479. ⟨10.1111/jam.14223⟩
Article dans une revue hal-02154448v1
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Determination of the dried product resistance variability and its influence on the product temperature in pharmaceutical freeze-drying

Bernadette Scutella , Ioan-Cristian Trelea , Erwan Bourlés , Fernanda Fonseca , Stéphanie Passot
European Journal of Pharmaceutics and Biopharmaceutics, 2018, 128, pp.379-388. ⟨10.1016/j.ejpb.2018.05.004⟩
Article dans une revue hal-01789065v1
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Effect of freeze-dryer design on heat transfer variability investigated using a 3D mathematical model

B. Scutellà , E. Bourlés , Artemio Plana-Fattori , F. Fonseca , D. Flick
Journal of Pharmaceutical Sciences, 2018, 107 (8), pp.2098-2106. ⟨10.1016/j.xphs.2018.04.002⟩
Article dans une revue hal-01769104v1
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The virtual food system: Innovative models and experiential feedback in technologies for winemaking, the cereals chain, food packaging and eco-designed starter production

Cesar Arturo Aceves-Lara , Violaine Athès , Patrice Buche , Guy Della Valle , Vincent Farines
Innovative Food Science & Emerging Technologies / Innovative Food Science and Emerging Technologies , 2018, Food Science and Technology in France: INRA’s contribution to this area, 46, pp.54-64. ⟨10.1016/j.ifset.2017.10.006⟩
Article dans une revue lirmm-01651998v1
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3D mathematical modelling to understand atypical heat transfer observed in vial freeze-drying

Bernadette Scutellà , Artemio Plana-Fattori , Stéphanie Passot , E Bourlès , Fernanda Fonseca
Applied Thermal Engineering, 2017, 126, pp.226 - 236. ⟨10.1016/j.applthermaleng.2017.07.096⟩
Article dans une revue hal-01582545v1
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How vial geometry variability influences heat transfer and product temperature during freeze-drying

Bernadette Scutella , Stéphanie Passot , Erwan Bourlés , Fernanda Fonseca , Ioan-Cristian Trelea
Journal of Pharmaceutical Sciences, 2017, 106 (3), pp.770-778. ⟨10.1016/j.xphs.2016.11.007⟩
Article dans une revue hal-01465155v1
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Dynamic modelling of the secondary drying stage of freeze-drying reveals distinct desorption kinetics for bound water

Ioan-Cristian Trelea , Fernanda Fonseca , Stéphanie Passot
Drying Technology, 2016, 34 (3), pp.335-345. ⟨10.1080/07373937.2015.1054509⟩
Article dans une revue hal-01531598v1
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A binary gas transport model Improves the prediction of mass transfer in freeze drying

Ioan-Cristian Trelea , Fernanda Fonseca , Stéphanie Passot , Denis Flick
Drying Technology, 2015, 33 (15-16), pp.1849-1858. ⟨10.1080/07373937.2015.1040025⟩
Article dans une revue hal-01269386v1
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Critical water activity and amorphous state for optimal preservation of lyophilised lactic acid bacteria

Stéphanie Passot , Stéphanie Cenard , Inès Douania , Ioan Cristian Trelea , Fernanda Fonseca
Food Chemistry, 2012, 132 (4), pp.1699-1705. ⟨10.1016/j.foodchem.2011.06.012⟩
Article dans une revue hal-01536691v1
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Toward Optimal Operation Conditions of Freeze-Drying Processes via a Multilevel Approach

Luis T. Antelo , Stéphanie Passot , Fernanda Fonseca , Ioan-Cristian Trelea , Antonio A. Alonso
Drying Technology, 2012, 30 (13), pp.1432 - 1448. ⟨10.1080/07373937.2012.686079⟩
Article dans une revue hal-01053126v1

Effect of controlled ice nucleation on primary drying stage and protein recovery in vials cooled in a modified freeze-dryer

Stéphanie Passot , Ioan-Cristian Trelea , Michele Marin , Miquel Galan , G. John Morris
Journal of Biomechanical Engineering, 2009, 131 (7), pp.074511:1-5. ⟨10.1115/1.3143034⟩
Article dans une revue hal-01537095v1
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Model for Heat and Mass Transfer in Freeze-Drying of Pellets

Ioan-Cristian Trelea , Stephanie Passot , Michele Marin , Fernanda Fonseca
Journal of Biomechanical Engineering, 2009, 131 (7), pp.074501. ⟨10.1115/1.3142975⟩
Article dans une revue hal-01536947v1
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An Interactive Tool for the Optimization of Freeze-Drying Cycles Based on Quality Criteria

Ioan-Cristian Trelea , Stéphanie Passot , Fernanda Fonseca , Michele Marin
Drying Technology, 2007, 25 (5), pp.741-751. ⟨10.1080/07373930701370100⟩
Article dans une revue hal-01537101v1

Complementary analytical approaches improving knowledge on lactic acid bacteria cryoresistance

Amélie Girardeau , Julie Meneghel , Ioan-Cristian Trelea , Stéphanie Passot , Fernanda Fonseca
56. Annual Meeting of the Society for Cryobiology, Jul 2019, San Diego, CA, United States. 166-166 p., ⟨10.1016/j.cryobiol.2019.10.086⟩
Communication dans un congrès hal-02266910v1

Use of a multi-vial mathematical model to design freeze-drying cycles for pharmaceuticals at known risk of failure

Bernadette Scutellà , Ioan-Cristian Trelea , Erwan Bourlés , Fernanda Fonseca , Stéphanie Passot
21. International Drying Symposium, Sep 2018, Valencia, Spain. ⟨10.4995/IDS2018.2018.7421⟩
Communication dans un congrès hal-02266914v1

Can the desorption kinetics explain the residual moisture content heterogeneity observed in pharmaceuticals freeze-drying process?

Bernadette Scutella , Erwan Bourlés , Cassandre Tordjman , Fernanda Fonseca , Yves Mayeresse
6. European Drying Conference: EuroDrying 2017, Jun 2017, Liège, Belgium
Communication dans un congrès hal-01604833v1
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Freeze-drying control by taking into account environmental considerations (communication orale)

Caroline Pénicaud , Ioan Cristian Tréléa , Bruno Perret , Fernanda Fonseca , Stéphanie Passot
FoodFactory, Oct 2016, Laval, France
Communication dans un congrès hal-01589685v1

How to manage scale-up using the design space approach

Bernadette Scutella , Erwan Bourlés , Fernanda Fonseca , Artemio Plana-Fattori , Denis Flick
2016 PDA Conference, Pharmaceutical Freeze Drying Technology, PDA., Sep 2016, Strasbourg, France
Communication dans un congrès hal-01567201v1

Eco-design of food and bio-processes: Example of production of stabilized lactic acid bacteria

Caroline Pénicaud , Vincent Monclus , Bruno Perret , Stéphanie Passot , Ioan-Cristian Trelea
Lecture at WUR, Sep 2016, Wageningen, Netherlands
Communication dans un congrès hal-01532620v1
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Finite elements model of heat transfer predicts the edge vial effect in different freeze-drying configurations

Bernadette Scutella , Stéphanie Passot , Erwan Bourlés , Fernanda Fonseca , Artemio Plana-Fattori
2016 CPPR Conference Freeze-Drying of Pharmaceuticals and Biologicals, Jul 2016, Breckenridge, United States
Communication dans un congrès hal-01567200v1

Inter-vial heat transfer heterogeneity during freeze-drying: role of vial geometry and position on the shelf

Bernadette Scutella , Stéphanie Passot , Erwan Bourlés , Fernanda Fonseca , Ioan-Cristian Trelea
7. International Conference ISL-FD, Jul 2015, Barcelona, Spain
Communication dans un congrès hal-01567216v1

Insights into freeze-drying energy consumptions for an environmentally-reasoned process control (poster)

Caroline Pénicaud , Ioan Cristian Tréléa , Bruno Perret , Fernanda Fonseca , Violaine Athes
GPE – 4th International Congress on Green Process Engineering, 2014, Seville, Spain. pp.546
Communication dans un congrès hal-01598171v1

A mutual gas diffusion model improves the prediction of mass transfer in freeze-drying (communication orale)

Ioan Cristian Tréléa , Fernanda Fonseca , Stéphanie Passot , Denis Flick
IDS 2014 - 19th International Drying Symposium, Aug 2014, Lyon, France
Communication dans un congrès hal-01598173v1

Freeze-drying modeling: prediction of spatial distribution of product quality

Stéphanie Passot , Fernanda Fonseca , Stéphanie Cenard , Ioan Cristian Tréléa
The Freeze Drying of Pharmaceuticals and Biologicals Conference, Sep 2014, Garmisch-Partenkirchen, Germany
Communication dans un congrès hal-01598172v1

Controlling ice nucleation: the Pros & the Cons

Fernanda Fonseca , Stéphanie Passot , Ioan Cristian Tréléa
PDA International Conference of Lyophilization and Freeze-drying, Oct 2013, Dusseldorf, Germany
Communication dans un congrès hal-01598177v1

Developing smart control strategies for the freeze-drying of bacteria

Stéphanie Passot , Fernanda Fonseca , Stéphanie Cenard , Carlos Vilas , Eva Balsa-Canto
ISL-FD: 5th International Conference on Lyophilization and Freeze Drying, 2012, Bologne, Italy
Communication dans un congrès hal-01598192v1

Developing smart control strategies for the freeze-drying of bacteria

Stéphanie Passot , Fernanda Fonseca , Stéphanie Cenard , C. Vilas , E. Balsa Canto
EFFoST Annual Meeting, Nov 2012, Montpellier, France
Communication dans un congrès hal-01628119v1

Real time optimization of freeze-drying of lactic acid bacteria (communication orale)

Stéphanie Passot , Carlos Vilas , Fernanda Fonseca , Stéphanie Cenard , Eva Balsa-Canto
SDDP2012 - 5th International Symposium on Spray Dried Dairy Products, Jun 2012, Saint-Malo, France
Communication dans un congrès hal-01598191v1

Developing smart control strategies of freeze-drying of lactic acid bacteria

Stéphanie Passot , Fernanda Fonseca , Stéphanie Cenard , Ioan-Cristian Trelea
5. International Conference on Lyophilization and Freeze Drying, Mar 2012, Bologne, Italy
Communication dans un congrès hal-01628100v1

Freeze-drying of lactic acid bacteria : effect of process variables on cell injury

Stéphanie S. Passot , Stéphanie Cenard , Ioan-Cristian I.-C. Trelea , Fernanda F. Fonseca
48. Annual Meeting of the Society for Cryobiology, Jul 2011, Corvallis, Oregon, United States. ⟨10.1016/j.cryobiol.2011.09.055⟩
Communication dans un congrès hal-02749196v1
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Quality degradation of lactic acid bacteria during the freeze drying process : experimental study and mathematical modelling

Stéphanie S. Passot , Fernanda F. Fonseca , Stéphanie Cenard , Ines Douania , Ioan-Cristian I.-C. Trelea
ICEF 11, International Congress of Engineering and Food, May 2011, Athens, Greece
Communication dans un congrès hal-02746624v1

Electronic nose characterization of the quality parameters of freeze-dried bacteria

R. Capuano , M. Santonico , E. Martinelli , R. Paolesse , Stéphanie S. Passot
14. International Symposium on Olfaction and Electronic Nose, May 2011, New York, United States. pp.125-126, ⟨10.1063/1.3626330⟩
Communication dans un congrès hal-02745659v1

Modeling for risk assessment of quality failures: Application to microorganisms

Stéphanie S. Passot , Ines Douania , Stéphanie Cenard , Fernanda F. Fonseca , Ioan-Cristian I.-C. Trelea
Freeze Drying of Pharmaceuticals and Biologicals Conference, Sep 2010, Garmisch-Partenkirchen, Germany
Communication dans un congrès hal-02751750v1

Water in freeze-dried lactic acid bacteria: Friend or Foe

Stéphanie S. Passot , Stéphanie Cenard , Ioan-Cristian I.-C. Trelea , Ines Douania , Fernanda F. Fonseca
EuroFoodWater, Mar 2010, Reims, France
Communication dans un congrès hal-02818597v1

Stabilization of lactic acid bacteria : relevance of physical properties on formulation and process efficiency

Fernanda F. Fonseca , Stéphanie Cenard , Ioan-Cristian I.-C. Trelea , Michele Marin , Stéphanie S. Passot
X. Congreso Latinoamericano de Microbiologia et Hygiena de los Alimentos, Oct 2009, Punta del Este, Uruguay
Communication dans un congrès hal-02750465v1

Computer modelling to optimise freeze-drying cycles

Stéphanie S. Passot , Ioan-Cristian I.-C. Trelea , Fernanda F. Fonseca
Visiongain's 2nd Annual Lyophilisation Conference, Sep 2009, London, United Kingdom
Communication dans un congrès hal-02750950v1

Lyophilisation of pellets : experimental and modelling study

Stéphanie S. Passot , Ioan-Cristian I.-C. Trelea , Fernanda F. Fonseca
Journée AFSIA-EFCA, 2009, lyon, France
Communication dans un congrès hal-02819808v1

Impact of freezing, especially the controlled nucleation, on protein freeze-drying efficiency

Stéphanie S. Passot , Fernanda F. Fonseca , Ioan-Cristian I.-C. Trelea , Michèle Marin
Informa Life Sciences. Lyophilization of Pharmaceuticals, 2008, Londres, United Kingdom
Communication dans un congrès hal-02813150v1

Stabilization of freeze-dried Lb Bulgaricus cells: the freezing kinetics effect

Fernanda F. Fonseca , Stéphanie S. Passot , Stéphanie Cenard , Ioan-Cristian I.-C. Trelea , Michele Marin
Annual Meeting of the Society for Cryobiology, Jul 2008, Charlotte, North Carolina, United States. ⟨10.1016/j.cryobiol.2008.10.090⟩
Communication dans un congrès hal-02752775v1

Quality by deisgn approach : the particular case of freeze-drying process

Stéphanie S. Passot , Michele Marin , Ioan-Cristian I.-C. Trelea , Fernanda F. Fonseca
2008 PDA Conference on Quality by Design, Oct 2008, Frankfurt, Germany
Communication dans un congrès hal-02814219v1

User-friendly modeling of the freeze-drying process

Stéphanie S. Passot , Fernanda F. Fonseca , Michèle Marin , Ioan-Cristian I.-C. Trelea
The Freeze Drying of Pharmaceuticals and Biologicals Conference, 2008, Breckenridge, CO, United States
Communication dans un congrès hal-02812410v1

Vacuum freeze-drying of a bed of food pellets: Experimental study and mathematical modelling

Stéphanie S. Passot , Fernanda F. Fonseca , Michèle Marin , Ioan-Cristian I.-C. Trelea
ICEF 10 - International Congress on Engineering and Food, Apr 2008, Vina del Mar, Chile
Communication dans un congrès hal-02816125v1

Freezing : a critical step for freeze-drying cycle development and product stability

Stéphanie S. Passot , Ioan-Cristian I.-C. Trelea , Stéphanie S. Cenard , Fernanda F. Fonseca
2008 ISPE Conference : Lyophilisation: Scientific Issues of the Process and Introduction to a Risk-Based Approach, Dec 2008, Barcelona, Spain
Communication dans un congrès hal-02750962v1

Impact of thermal properties on protein formulation and freeze-drying cycle development

Stéphanie S. Passot , Fernanda F. Fonseca , Ioan-Cristian I.-C. Trelea , Michèle Marin
ISPE Conference on Manufacturing Excellence 2008. Lyophilization: Meeting the Challenges of a Critical Technology, 2008, Tempa,Fl, United States
Communication dans un congrès hal-02815517v1

Vacuum freeze-drying of food pellets : experimental study and mathematical modelling

Stéphanie S. Passot , Fernanda F. Fonseca , Michele Marin , Ioan-Cristian I.-C. Trelea
ICEF 10 - International Congress on Engineering and Food, Apr 2008, Vina del Mar, Chile
Communication dans un congrès hal-02811586v1

Stabilisation of lactic acid bacteria: relevance of physical properties on formulation efficiency

Fernanda F. Fonseca , Stéphanie S. Passot , Stéphanie S. Cenard , Ioan-Cristian I.-C. Trelea , Michele Marin
1. Int. DOM Symposium on Microbial Formulation, 2007, Uppsala, Sweden
Communication dans un congrès hal-02813661v1

Controlled nucleation improves the efficiency pharmaceutical proteins lyophilization

Stéphanie S. Passot , Fernanda F. Fonseca , Ioan-Cristian I.-C. Trelea , Alice Remillieux , M. Galan
Journées AFSIA-EFCE, May 2007, Biarritz, France
Communication dans un congrès hal-02821076v1

An interactive tool for freeze-drying cycle optimisation based on product quality criteria

Ioan-Cristian I.-C. Trelea , Stéphanie S. Passot , Fernanda F. Fonseca , Michele Marin
Informa Life Sciences. Lyophilization of Pharmaceuticals, Dec 2007, London, United Kingdom
Communication dans un congrès hal-02814381v1

Impact of physical properties of bioproducts on formulation and freeze-drying cycle development

Fernanda F. Fonseca , Stéphanie S. Passot , Ioan-Cristian I.-C. Trelea , Michele Marin
International Society for Pharmaceutical Engineering (ISPE). Lyophilization Technologies and Practice Seminar, Sep 2006, Vienna, Austria
Communication dans un congrès hal-02812611v1

Integration of glass transition in freeze-drying kinetic modelling to improve protein stability

Stéphanie S. Passot , Ioan-Cristian I.-C. Trelea , Fernanda F. Fonseca , Naziha Barbouche , Michele Marin
13. World Congress of Food Science and Technology "Food is Life", IUFOST XIIIth Congress, Jul 2006, Nantes, France. ⟨10.1051/IUFoST:20060715⟩
Communication dans un congrès hal-02751252v1

Impact of physical properties of bioproducts on formulation and on freeze-drying cycle development

Fernanda F. Fonseca , Stéphanie S. Passot , Ioan-Cristian I.-C. Trelea , Michele Marin
International Society for Pharmaceutical Engineering (ISPE). Lyophilization - Technologies and Practice- Seminar, Sep 2006, Vienna, Austria
Communication dans un congrès hal-02812984v1

An interactive tool for freeze-drying cycle optimization based on product quality criteria

Ioan-Cristian I.-C. Trelea , Stéphanie S. Passot , Fernanda F. Fonseca , Michèle Marin
Journées AFSIA-EFCE, May 2005, Paris, France
Communication dans un congrès hal-02827039v1

Examining the current status of Process Analytical Technology applied to lyophilization: Instrumentation, kinetics, quality criteria and risks area in the cycle

Stéphanie S. Passot , Fernanda F. Fonseca , Ioan-Cristian I.-C. Trelea , Michèle Marin
Barnett International’s Annual Conference on Freeze-drying, Jun 2004, Dublin, Ireland
Communication dans un congrès hal-02829880v1
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Modélisation thermodynamique de la croissance microbienne

Cedric Dussat , Cristian Puentes , Ioan-Cristian Trelea , Fernanda Fonseca , Stephanie Passot
Microbes 2021 16ème congrès national de la SFM, Sep 2021, Nantes, France
Poster de conférence hal-04459518v1

Freeze-drying in atypical vials: how to model heat transfer during sublimation by using 3D mathematical modelling

Juan Buceta Correa de Borba , Stéphanie Passot , Bernadette Scutellà , Fernanda Fonseca , Erwan Bourles
9. International Symposium on Lyophilization and Pharmaceutics ISLFD 2019, Sep 2019, Ghent, Belgium. 2019, 9th International Symposium on Lyophilization and Pharmaceutics ISLFD 2019
Poster de conférence hal-02268926v1
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Mapping the physiological states of Carnobacterium maltaromaticum obtained” by applying stressful fermentation conditions

Amélie Girardeau , Cristian Felipe Puentes Mancipe , Sophie Keravec , Pierre Peteuil , Ioan-Cristian Trelea
4. Microbial Stress: from systems to molecules and back, Apr 2018, Cork, Ireland. 2018, 4th Microbial Stress: from systems to molecules and back
Poster de conférence hal-02268919v1

Freeze-drying of bacteria: From the understanding of the mechanisms of cell resistance to the sustainable process development and optimization

Stéphanie Passot , Caroline Pénicaud , Marielle Bouix , Bruno Perret , Ioan-Cristian Trelea
21. Colloque du Club de Bactéries Lactiques, Jun 2017, Lille, France. 2017
Poster de conférence hal-02266907v1

Freeze-drying of bacteria : state of the art and new perspectives

Stéphanie Passot , Ioan-Cristian Trelea , Stéphanie Cenard , Fernanda Fonseca
7. International Conference of Lyophilization and Freeze-Drying, Jul 2015, Barcelona, Spain. 2015
Poster de conférence hal-01535314v1

Scale-up of freeze-drying cycles, the use of process analytical technology (PAT), and statistical analysis

Erwan Bourlès , Gael de Lannoy , Bernadette Scutellà , Fernanda Fonseca , Ioan-Cristian Trelea
Lyophilization of Pharmaceuticals and Biologicals, Editions Springer, 2019, Methods in Pharmacology and Toxicology, 978-1-4939-8927-0. ⟨10.1007/978-1-4939-8928-7_10⟩
Chapitre d'ouvrage hal-02266898v1