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Fernanda FONSECA
66
Documents
Affiliations actuelles
Identifiants chercheurs
- fernanda-fonseca
- ResearcherId : AAR-9094-2020
- 0000-0003-3394-182X
- Google Scholar : https://scholar.google.fr/citations?user=roNN7VMAAAAJ&hl=fr
- IdRef : 057054649
Présentation
#### **EDUCATION**
**Habilitation à Diriger des Recherches (HDR).** Université de Technologie de Compiègne, 2010. Title : « Stabilization of bio functionalities trough an approach combining the understanding of mechanisms and the product-process engineering”
**Ph.D. Degree** in **Biotechnology and Process Engineering**, Institut National Agronomique Paris-Grignon (AgroParisTech),**2001**. Ph.D. thesis title: "Influence of cryoprotection and freezing on the acidification activity of thermopile lactic acid bacteria: relationships between biological and thermodynamic properties."
**Master Degree** in **Biotechnology and Process Engineering**, Institut National Agronomique Paris-Grignon (AgroParisTech), **1997**. M.Sc. thesis title: "Study of the freezing step on the activity of frozen lactic acid starters."
Engineer** in **Chemical Engineering**, Montevideo University (Uruguay), **1996.**
**SCIENTIFIC EXPERIENCE**
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**Research Director (since January 2015),** in Paris-Saclay Food and Bioproduct Engineering research unit (UMR 782 SayFood INRAE-AgroParisTech), Versailles-Grignon Centre, at the French National Institute for Agriculture, Food and Environment (INRAE), France.
**Researcher Scientist** (**September 2001 – December 2014**), in the Joint Research Unit for Food Process Engineering and Microbiology (UMR 782 GMPA INRA-AgroParisTech), Versailles-Grignon Centre, Institut National de la Recherche Agronomique (INRA), France.
**Main fields of expertise:**Biotechnology and process engineering: fermentation, formulation, and stabilization of bioproducts.
- Bioproducts: micro-organisms, proteins, food products.
- Stabilization processes: freezing and freeze-drying
- Biophysical characterization of bioproducts (thermal analysis, freeze-drying microscopy, Fourier Transformed InfraRed microspectroscopy)
**Research approach:** Focusing on biophysical and chemical behaviors of bioproducts during stabilization processes and by relating them to biological and functional responses, to identify and quantify the mechanisms governing the degradation and preservation of bioproducts during the stabilization processes. The ambition is also to find general principles for simplifying and rationalizing the development of newly formulated products and the stabilization process optimization, with particular attention to limiting the environmental impact.
Domaines de recherche
Compétences
Publications
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Complementary analytical approaches improving knowledge on lactic acid bacteria cryoresistance56. Annual Meeting of the Society for Cryobiology, Jul 2019, San Diego, CA, United States. 166-166 p., ⟨10.1016/j.cryobiol.2019.10.086⟩
Communication dans un congrès
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Use of a multi-vial mathematical model to design freeze-drying cycles for pharmaceuticals at known risk of failure21. International Drying Symposium, Sep 2018, Valencia, Spain. ⟨10.4995/IDS2018.2018.7421⟩
Communication dans un congrès
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Can the desorption kinetics explain the residual moisture content heterogeneity observed in pharmaceuticals freeze-drying process?6. European Drying Conference: EuroDrying 2017, Jun 2017, Liège, Belgium
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Freeze-drying control by taking into account environmental considerations (communication orale)FoodFactory, Oct 2016, Laval, France
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How to manage scale-up using the design space approach2016 PDA Conference, Pharmaceutical Freeze Drying Technology, PDA., Sep 2016, Strasbourg, France
Communication dans un congrès
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Eco-design of food and bio-processes: Example of production of stabilized lactic acid bacteriaLecture at WUR, Sep 2016, Wageningen, Netherlands
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Finite elements model of heat transfer predicts the edge vial effect in different freeze-drying configurations2016 CPPR Conference Freeze-Drying of Pharmaceuticals and Biologicals, Jul 2016, Breckenridge, United States
Communication dans un congrès
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Inter-vial heat transfer heterogeneity during freeze-drying: role of vial geometry and position on the shelf7. International Conference ISL-FD, Jul 2015, Barcelona, Spain
Communication dans un congrès
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Insights into freeze-drying energy consumptions for an environmentally-reasoned process control (poster)GPE – 4th International Congress on Green Process Engineering, 2014, Seville, Spain. pp.546
Communication dans un congrès
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A mutual gas diffusion model improves the prediction of mass transfer in freeze-drying (communication orale)IDS 2014 - 19th International Drying Symposium, Aug 2014, Lyon, France
Communication dans un congrès
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Freeze-drying modeling: prediction of spatial distribution of product qualityThe Freeze Drying of Pharmaceuticals and Biologicals Conference, Sep 2014, Garmisch-Partenkirchen, Germany
Communication dans un congrès
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Controlling ice nucleation: the Pros & the ConsPDA International Conference of Lyophilization and Freeze-drying, Oct 2013, Dusseldorf, Germany
Communication dans un congrès
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Developing smart control strategies for the freeze-drying of bacteriaISL-FD: 5th International Conference on Lyophilization and Freeze Drying, 2012, Bologne, Italy
Communication dans un congrès
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Developing smart control strategies for the freeze-drying of bacteriaEFFoST Annual Meeting, Nov 2012, Montpellier, France
Communication dans un congrès
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Real time optimization of freeze-drying of lactic acid bacteria (communication orale)SDDP2012 - 5th International Symposium on Spray Dried Dairy Products, Jun 2012, Saint-Malo, France
Communication dans un congrès
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Developing smart control strategies of freeze-drying of lactic acid bacteria5. International Conference on Lyophilization and Freeze Drying, Mar 2012, Bologne, Italy
Communication dans un congrès
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Freeze-drying of lactic acid bacteria : effect of process variables on cell injury48. Annual Meeting of the Society for Cryobiology, Jul 2011, Corvallis, Oregon, United States. ⟨10.1016/j.cryobiol.2011.09.055⟩
Communication dans un congrès
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Quality degradation of lactic acid bacteria during the freeze drying process : experimental study and mathematical modellingICEF 11, International Congress of Engineering and Food, May 2011, Athens, Greece
Communication dans un congrès
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Electronic nose characterization of the quality parameters of freeze-dried bacteria14. International Symposium on Olfaction and Electronic Nose, May 2011, New York, United States. pp.125-126, ⟨10.1063/1.3626330⟩
Communication dans un congrès
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Modeling for risk assessment of quality failures: Application to microorganismsFreeze Drying of Pharmaceuticals and Biologicals Conference, Sep 2010, Garmisch-Partenkirchen, Germany
Communication dans un congrès
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Water in freeze-dried lactic acid bacteria: Friend or FoeEuroFoodWater, Mar 2010, Reims, France
Communication dans un congrès
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Stabilization of lactic acid bacteria : relevance of physical properties on formulation and process efficiencyX. Congreso Latinoamericano de Microbiologia et Hygiena de los Alimentos, Oct 2009, Punta del Este, Uruguay
Communication dans un congrès
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Computer modelling to optimise freeze-drying cyclesVisiongain's 2nd Annual Lyophilisation Conference, Sep 2009, London, United Kingdom
Communication dans un congrès
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Lyophilisation of pellets : experimental and modelling studyJournée AFSIA-EFCA, 2009, lyon, France
Communication dans un congrès
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Impact of freezing, especially the controlled nucleation, on protein freeze-drying efficiencyInforma Life Sciences. Lyophilization of Pharmaceuticals, 2008, Londres, United Kingdom
Communication dans un congrès
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Stabilization of freeze-dried Lb Bulgaricus cells: the freezing kinetics effectAnnual Meeting of the Society for Cryobiology, Jul 2008, Charlotte, North Carolina, United States. ⟨10.1016/j.cryobiol.2008.10.090⟩
Communication dans un congrès
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Quality by deisgn approach : the particular case of freeze-drying process2008 PDA Conference on Quality by Design, Oct 2008, Frankfurt, Germany
Communication dans un congrès
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User-friendly modeling of the freeze-drying processThe Freeze Drying of Pharmaceuticals and Biologicals Conference, 2008, Breckenridge, CO, United States
Communication dans un congrès
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Vacuum freeze-drying of a bed of food pellets: Experimental study and mathematical modellingICEF 10 - International Congress on Engineering and Food, Apr 2008, Vina del Mar, Chile
Communication dans un congrès
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Freezing : a critical step for freeze-drying cycle development and product stability2008 ISPE Conference : Lyophilisation: Scientific Issues of the Process and Introduction to a Risk-Based Approach, Dec 2008, Barcelona, Spain
Communication dans un congrès
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Impact of thermal properties on protein formulation and freeze-drying cycle developmentISPE Conference on Manufacturing Excellence 2008. Lyophilization: Meeting the Challenges of a Critical Technology, 2008, Tempa,Fl, United States
Communication dans un congrès
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Vacuum freeze-drying of food pellets : experimental study and mathematical modellingICEF 10 - International Congress on Engineering and Food, Apr 2008, Vina del Mar, Chile
Communication dans un congrès
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Stabilisation of lactic acid bacteria: relevance of physical properties on formulation efficiency1. Int. DOM Symposium on Microbial Formulation, 2007, Uppsala, Sweden
Communication dans un congrès
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Controlled nucleation improves the efficiency pharmaceutical proteins lyophilizationJournées AFSIA-EFCE, May 2007, Biarritz, France
Communication dans un congrès
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An interactive tool for freeze-drying cycle optimisation based on product quality criteriaInforma Life Sciences. Lyophilization of Pharmaceuticals, Dec 2007, London, United Kingdom
Communication dans un congrès
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Impact of physical properties of bioproducts on formulation and freeze-drying cycle developmentInternational Society for Pharmaceutical Engineering (ISPE). Lyophilization Technologies and Practice Seminar, Sep 2006, Vienna, Austria
Communication dans un congrès
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Integration of glass transition in freeze-drying kinetic modelling to improve protein stability13. World Congress of Food Science and Technology "Food is Life", IUFOST XIIIth Congress, Jul 2006, Nantes, France. ⟨10.1051/IUFoST:20060715⟩
Communication dans un congrès
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Impact of physical properties of bioproducts on formulation and on freeze-drying cycle developmentInternational Society for Pharmaceutical Engineering (ISPE). Lyophilization - Technologies and Practice- Seminar, Sep 2006, Vienna, Austria
Communication dans un congrès
hal-02812984v1
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An interactive tool for freeze-drying cycle optimization based on product quality criteriaJournées AFSIA-EFCE, May 2005, Paris, France
Communication dans un congrès
hal-02827039v1
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Examining the current status of Process Analytical Technology applied to lyophilization: Instrumentation, kinetics, quality criteria and risks area in the cycleBarnett International’s Annual Conference on Freeze-drying, Jun 2004, Dublin, Ireland
Communication dans un congrès
hal-02829880v1
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Modélisation thermodynamique de la croissance microbienneMicrobes 2021 16ème congrès national de la SFM, Sep 2021, Nantes, France
Poster de conférence
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Freeze-drying in atypical vials: how to model heat transfer during sublimation by using 3D mathematical modelling9. International Symposium on Lyophilization and Pharmaceutics ISLFD 2019, Sep 2019, Ghent, Belgium. 2019, 9th International Symposium on Lyophilization and Pharmaceutics ISLFD 2019
Poster de conférence
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Mapping the physiological states of Carnobacterium maltaromaticum obtained” by applying stressful fermentation conditions4. Microbial Stress: from systems to molecules and back, Apr 2018, Cork, Ireland. 2018, 4th Microbial Stress: from systems to molecules and back
Poster de conférence
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Freeze-drying of bacteria: From the understanding of the mechanisms of cell resistance to the sustainable process development and optimization21. Colloque du Club de Bactéries Lactiques, Jun 2017, Lille, France. 2017
Poster de conférence
hal-02266907v1
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Freeze-drying of bacteria : state of the art and new perspectives7. International Conference of Lyophilization and Freeze-Drying, Jul 2015, Barcelona, Spain. 2015
Poster de conférence
hal-01535314v1
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Scale-up of freeze-drying cycles, the use of process analytical technology (PAT), and statistical analysisLyophilization of Pharmaceuticals and Biologicals, Editions Springer, 2019, Methods in Pharmacology and Toxicology, 978-1-4939-8927-0. ⟨10.1007/978-1-4939-8928-7_10⟩
Chapitre d'ouvrage
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