Frédéric Jean-Alphonse

Publications

Article dans une revue (39)

Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy Amaury Herbet,Marie Hautière,Frédéric Jean-Alphonse,Delphine Vivier,Christophe Leboeufet al. British journal of cancer reports, 2025, 3 (1), pp.3. ⟨10.1038/s44276-024-00109-y⟩ Article dans une revue hal-05283402v1
Trafficking of luteinizing hormone receptor directs the differential signal activation between luteinizing hormone and chorionic gonadotropin Clara Lazzaretti,Elia Paradiso,Samantha Sperduti,Rachel Richardson,Carmela Perriet al. International Journal of Biological Macromolecules, 2025, 318 (3), pp.145247. ⟨10.1016/j.ijbiomac.2025.145247⟩ Article dans une revue hal-05190057v1
Endogenous ligands of bovine FFAR2/GPR43 display distinct pharmacological properties Tainara Cristina Michelotti,Valérie Lamothe,Frédéric Jean-Alphonse,Eric Reiter,Muriel Bonnetet al. Frontiers in Cell and Developmental Biology, 2025, 13, pp.1645031. ⟨10.3389/fcell.2025.1645031⟩ Article dans une revue hal-05218647v1
An intracellular VHH targeting the Luteinizing Hormone receptor modulates G protein-dependent signaling and steroidogenesis Camille Gauthier,Pauline Raynaud,Frédéric Jean-Alphonse,Amandine Vallet,Océane Vaugrenteet al. Molecular and Cellular Endocrinology, 2024, 589, pp.112235. ⟨10.1016/j.mce.2024.112235⟩ Article dans une revue hal-04564514v1
Editorial: Pharmacology of endocrine related GPCRs Francesco de Pascali,Aylin Hanyaloglu,Frédéric Jean-Alphonse,Francesco Potì,Eric Reiter Frontiers in Endocrinology, 2024, 15, pp.1379108. ⟨10.3389/fendo.2024.1379108⟩ Article dans une revue hal-04525032v1
A single‐domain intrabody targeting the follicle‐stimulating hormone receptor impacts FSH ‐induced G protein‐dependent signalling Pauline Raynaud,Vinesh Jugnarain,Océane Vaugrente,Amandine Vallet,Thomas Bouloet al. FEBS Letters, 2024, 598 (2), pp.220-232. ⟨10.1002/1873-3468.14765⟩ Article dans une revue hal-04564581v1
Investigating the effects of steroid hormones on G protein-coupled receptors $in\ vitro$ Mohammed Akli Ayoub,Eric Reiter,Frédéric Jean-Alphonse LE STUDIUM Multidisciplinary Journal, 2023, 7 (9), pp.58-64. ⟨10.34846/le-studium.126.02.fr.08-2023⟩ Article dans une revue hal-05077676v1
Highly-Sensitive In Vitro Bioassays for FSH, TSH, PTH, Kp, and OT in Addition to LH in Mouse Leydig Tumor Cell Danièle Klett,Lucie Pellissier,Didier Lomet,Flavie Derouin Tochon,Vincent Robertet al. International Journal of Molecular Sciences, 2023, 24 (15), pp.12047. ⟨10.3390/ijms241512047⟩ Article dans une revue hal-04206799v1
Research fellowship in antibody fragments targeting ovarian GPCRs to control reproduction Anielka Zehnaker,Amandine Vallet,Juliette Gourdon,Caterina Sarti,Vinesh Jugnarainet al. LE STUDIUM Multidisciplinary Journal, 2023, 7, pp.138-149. ⟨10.34846/le-studium.251.05.fr.11-2023⟩ Article dans une revue hal-05077961v1
Combined multiplexed phage display, high-throughput sequencing, and functional assays as a platform for identifying modulatory VHHs targeting the FSHR Anielka Zehnaker,Amandine Vallet,Juliette Gourdon,Caterina Sarti,Vinesh Jugnarainet al. International Journal of Molecular Sciences, 2023, 24 (21), pp.15961. ⟨10.3390/ijms242115961⟩ Article dans une revue hal-04274818v1
Biased GPCR signaling by the native parathyroid hormone–related protein 1 to 141 relative to its N-terminal fragment 1 to 36 Karina A Peña,Alex D White,Sofya Savransky,Ignacio Portales Castillo,Frédéric G Jean-Alphonseet al. Journal of Biological Chemistry, 2022, 298 (9), pp.102332. ⟨10.1016/j.jbc.2022.102332⟩ Article dans une revue hal-03854828v1
Intracellular VHHs to monitor and modulate GPCR signaling Pauline Raynaud,Camille Gauthier,Vinesh Jugnarain,Frédéric Jean-Alphonse,Eric Reiteret al. Frontiers in Endocrinology, 2022, 13, pp.1048601. ⟨10.3389/fendo.2022.1048601⟩ Article dans une revue hal-03892398v1
Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation Alex D. White,Karina A. Peña,Lisa J. Clark,Christian Santa Maria,Shi Liuet al. Science Signaling, 2021, 14 (703), ⟨10.1126/scisignal.abc5944⟩ Article dans une revue hal-03476364v1
Pharmacological characterization of low molecular weight biased agonists at the follicle stimulating hormone receptor Francesco de Pascali,Mohammed Akli Ayoub,Riccardo Benevelli,Silvia Sposini,Jordan Lehouxet al. International Journal of Molecular Sciences, 2021, 22 (18), pp.1-23. ⟨10.3390/ijms22189850⟩ Article dans une revue hal-03351267v1
G q/11 -dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR Alex White,Frédéric Jean-Alphonse,Fei Fang,Karina Pena,Shi Liuet al. Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (13), pp.7455-7460. ⟨10.1073/pnas.1918158117⟩ Article dans une revue hal-03117167v1
Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation Lisa Clark,James Krieger,Alex White,Vasyl Bondarenko,Saifei Leiet al. Nature Chemical Biology, 2020, 16 (10), pp.1096-1104. ⟨10.1038/s41589-020-0567-0⟩ Article dans une revue hal-03117168v1
PTH hypersecretion triggered by a GABAB1 and Ca2+-sensing receptor heterocomplex in hyperparathyroidism Wenhan Chang,Chia-Ling Tu,Frédéric Jean-Alphonse,Amanda Herberger,Zhiqiang Chenget al. Nature Metabolism, 2020, 2 (3), pp.243-255. ⟨10.1038/s42255-020-0175-z⟩ Article dans une revue hal-03117169v1
Structure and dynamics of the active human parathyroid hormone receptor-1 Li-Hua Zhao,Shanshan Ma,Ieva Sutkeviciute,Dan-Dan Shen,X. Edward Zhouet al. Science, 2019, 364 (6436), pp.148-153. ⟨10.1126/science.aav7942⟩ Article dans une revue hal-03117165v1
Biased signaling and allosteric modulation at the FSHR Flavie Landomiel,Francesco de Pascali,Pauline Raynaud,Frédéric Jean-Alphonse,Romain Yvinecet al. Frontiers in Endocrinology, 2019, 10, pp.148. ⟨10.3389/fendo.2019.00148⟩ Article dans une revue (article de synthèse) hal-02362523v1
Use of backbone modification to enlarge the spatiotemporal diversity of parathyroid hormone receptor-1 signaling via biased agonism Shi Liu,Frédéric Jean-Alphonse,Alex D. White,Denise Wootten,Patrick M. Sextonet al. Journal of the American Chemical Society, 2019, 141 (37), pp.14486-14490. ⟨10.1021/jacs.9b04179⟩ Article dans une revue hal-03117166v1
Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport Qiangmin Zhang,Kunhong Xiao,Jose M. Paredes,Tatyana Mamonova,W. Bruce Sneddonet al. Journal of Biological Chemistry, 2019, 294 (12), pp.4546 - 4571. ⟨10.1074/jbc.RA119.007421⟩ Article dans une revue hal-02628955v1
Ca 2+ allostery in PTH-receptor signaling Alex White,Fei Fang,Frédéric Jean-Alphonse,Lisa Clark,Hyun-Jung Anet al. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (8), pp.3294-3299. ⟨10.1073/pnas.1814670116⟩ Article dans une revue hal-03117164v1
Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport Qiangmin Zhang,Kunhong Xiao,Jose Paredes,Tatyana Mamonova,W. Bruce Sneddonet al. Journal of Biological Chemistry, 2019, 294 (12), pp.4546-4571. ⟨10.1074/jbc.RA119.007421⟩ Article dans une revue hal-03117163v1
Integration of GPCR signaling and sorting from very early endosomes via opposing APPL1 mechanisms Silvia Sposini,Frederic G. Jean-Alphonse,Mohammed Akli Ayoub,Affiong Oqua,Camilla Westet al. Cell Reports, 2017, 21 (10), pp.2855-2867. ⟨10.1016/j.celrep.2017.11.023⟩ Article dans une revue hal-02625571v1
Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release Yalikun Suofu,Wei Li,Frédéric Jean-Alphonse,Jiaoying Jia,Nicolas Khattaret al. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (38), pp.E7997-E8006. ⟨10.1073/pnas.1705768114⟩ Article dans une revue hal-03117160v1
β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ Frédéric Jean-Alphonse,Vanessa Wehbi,Jingming Chen,Masaki Noda,Juan Taboaset al. Nature Chemical Biology, 2017, 13 (3), pp.259-261. ⟨10.1038/nchembio.2267⟩ Article dans une revue hal-03117157v1
Cdc42 activation couples fluid shear stress to apical endocytosis in proximal tubule cells Sohinee Bhattacharyya,Frédéric Jean-Alphonse,Venkatesan Raghavan,Jennifer Mcgarvey,Youssef Rbaibiet al. Physiological Reports, 2017, 5 (19), pp.1-26. ⟨10.14814/phy2.13460⟩ Article dans une revue hal-03117161v1
Design and validation of the first cell-impermeant melatonin receptor agonist Florence Gbahou,Erika Cecon,Guillaume Viault,Romain Gerbier,Frédéric Jean-Alphonseet al. British Journal of Pharmacology, 2017, 174 (14), pp.2409-2421. ⟨10.1111/bph.13856⟩ Article dans une revue hal-02873466v1
Actin-Sorting Nexin 27 (SNX27)-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling Jennifer Mcgarvey,Kunhong Xiao,Shanna Bowman,Tatyana Mamonova,Qiangmin Zhanget al. Journal of Biological Chemistry, 2016, 291 (21), pp.10986-11002. ⟨10.1074/jbc.M115.697045⟩ Article dans une revue hal-03117156v1
The polycystin-1, lipoxygenase, and α -toxin domain regulates polycystin-1 trafficking Yaoxian Xu,Andrew Streets,Andrea Hounslow,Uyen Tran,Frédéric Jean-Alphonseet al. Journal of the American Society of Nephrology, 2016, 27 (4), pp.1159-1173. ⟨10.1681/ASN.2014111074⟩ Article dans une revue hal-03117155v1
Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase Alexandre Gidon,Mohammad Al-Bataineh,Frédéric Jean-Alphonse,Hilary Stevenson,Tomoyuki Watanabeet al. Nature Chemical Biology, 2014, 10 (9), pp.707-709. ⟨10.1038/nchembio.1589⟩ Article dans une revue hal-03117152v1
Spatially Restricted G Protein-coupled Receptor Activity via Divergent Endocytic Compartments Frédéric Jean-Alphonse,Shanna Bowersox,Stanford Chen,Gemma Beard,Manojkumar Puthenveeduet al. Journal of Biological Chemistry, 2014, 289 (7), pp.3960-3977. ⟨10.1074/jbc.M113.526350⟩ Article dans une revue hal-03117150v1
Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential Evanthia Nikolopoulou,Georgia Papacleovoulou,Frédéric Jean-Alphonse,Giulia Grimaldi,Malcolm Parkeret al. Journal of Lipid Research, 2014, 55 (12), pp.2479-2490. ⟨10.1194/jlr.M049551⟩ Article dans une revue hal-03117154v1
Endosomal generation of cAMP in GPCR signaling Jean-Pierre Vilardaga,Frédéric Jean-Alphonse,Thomas Gardella Nature Chemical Biology, 2014, 10 (9), pp.700-706. ⟨10.1038/nchembio.1611⟩ Article dans une revue hal-03117153v1
Regulation of GPCR signal networks via membrane trafficking Frédéric Jean-Alphonse,A.C. Hanyaloglu Molecular and Cellular Endocrinology, 2011, 331 (2), pp.205-214. ⟨10.1016/j.mce.2010.07.010⟩ Article dans une revue hal-03117149v1
Past, present and future of vasopressin and oxytocin receptor oligomers, prototypical GPCR models to study dimerization processes M. Cottet,L Albizu,S Perkovska,Frédéric Jean-Alphonse,R Rahmehet al. Current Opinion in Pharmacology, 2010, 10 (1), pp.59-66. ⟨10.1016/j.coph.2009.10.003⟩ Article dans une revue istex hal-03117146v1
Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus. Frédéric Jean-Alphonse,Sanja Perkovska,Marie-Céline Frantz,Thierry Durroux,Catherine Méjeanet al. Journal of the American Society of Nephrology, 2009, 20 (10), pp.2190-203. ⟨10.1681/ASN.2008121289⟩ Article dans une revue inserm-00421838v1
The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V-2 receptor Sebastien Granier,Frederic Jean-Alphonse,Daniel Bacqueville,Arnaud Monteil,Robert Pascalet al. Regulatory Peptides, 2008, 148, pp.76-87. ⟨10.1016/j.regpep.2008.01.007⟩ Article dans une revue istex hal-00493436v1
Design and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRs Sébastien Granier,Frédéric Jean-Alphonse,Hélène Déméné,Gilles Guillon,Robert Pascalet al. Bioorganic and Medicinal Chemistry Letters, 2006, 16 (3), pp.521-524. ⟨10.1016/j.bmcl.2005.10.061⟩ Article dans une revue istex hal-03117141v1

Chapitre d'ouvrage (2)

β-arrestins and endocrine-related GPCRs Francesco de Pascali,Pauline Raynaud,Frédéric Jean-Alphonse,Shifa Tahir,Véronique Bozonet al. Cellular Endocrinology in Health and Disease, Elsevier, pp.445-458, 2021, 978-0-12-819801-8. ⟨10.1016/B978-0-12-819801-8.00021-1⟩ Chapitre d'ouvrage hal-03462802v1
Confocal and TIRF microscopy based approaches to visualize arrestin trafficking in living cells Frédéric Jean-Alphonse,Silvia Sposini Biomolecular Interactions Part A, 166, Elsevier, pp.179-203, 2021, Methods in Cell Biology, ⟨10.1016/bs.mcb.2021.06.009⟩ Chapitre d'ouvrage hal-03476372v1