Florian CHAIN

Publications

Article dans une revue (54)

SOD mimics delivered to the gut using lactic acid bacteria mitigate the colitis symptoms in a mouse model of Inflammatory Bowel Diseases Gabrielle Schanne,Amandine Vincent,Florian Chain,Pauline Ruffié,Célia Carbonneet al. Free Radical Research, In press, 59 (3), pp.262-273. ⟨10.1080/10715762.2025.2478121⟩ Article dans une revue hal-04999251v1
REG3A and IL22 have opposite effects on fat accumulation in the liver in a high-fat diet Esther Borras Nogues,Sandrine Auger,Alisson Agus,Aurélia Bruneau,Florian Chainet al. Scientific Reports, 2025, 15 (1), pp.33733. ⟨10.1038/s41598-024-84700-w⟩ Article dans une revue hal-05590173v1
Recombinant MAM from Faecalibacterium duncaniae exhibits a protective effect in DNBS-induced colitis Thaís Vilela Rodrigues,Luís Lima de Jesus,Monique Ferrary Américo,Florian Chain,Laura Creusotet al. Microbial Cell Factories, 2025, 25 (1), pp.6. ⟨10.1186/s12934-025-02877-9⟩ Article dans une revue hal-05593025v1
Ligilactobacillus salivarius CNCM I-4866, a potential probiotic candidate, shows anti-inflammatory properties in vitro and in vivo Celia Carbonne,Sead Chadi,Camille Kropp,Lise Molimard,Florian Chainet al. Frontiers in Microbiology, 2023, 14, ⟨10.3389/fmicb.2023.1270974⟩ Article dans une revue hal-04339489v1
Time-Restricted Feeding Potentiates the Ability of Lacticaseibacillus casei to Enrich the Retina in Omega-3 Fatty Acids Pierre Lapaquette,Anne-Sophie Boucard,Florian Chain,Stéphane Grégoire,Luis Bermúdez-Humaránet al. Aging and disease, 2023, 14 (6), pp.1945-1949. ⟨10.14336/AD.2023.0324⟩ Article dans une revue hal-04101285v1
An Isolate of Streptococcus mitis Displayed In Vitro Antimicrobial Activity and Deleterious Effect in a Preclinical Model of Lung Infection Elliot Mathieu,Quentin Marquant,Florian Chain,Edwige Bouguyon,Vinciane Saint-Criqet al. Nutrients, 2023, 15 (2), pp. 263. ⟨10.3390/nu15020263⟩ Article dans une revue hal-03943007v1
Gut barrier-microbiota imbalances in early life lead to higher sensitivity to inflammation in a murine model of C-section delivery M. Barone,Y. Ramayo-Caldas,J. Estellé,K. Tambosco,S. Chadiet al. Microbiome, 2023, 11 (1), pp.140. ⟨10.1186/s40168-023-01584-0⟩ Article dans une revue hal-04344510v1
Lactococcus lactis engineered to deliver hCAP18 cDNA alleviates DNBS-induced colitis in C57BL/6 mice by promoting IL17A and IL10 cytokine expression Esther Borras Noguès,Camille Kropp,Laureline Bétemps,Cassiana de Sousa,Florian Chainet al. Scientific Reports, 2022, 12 (1), pp.15641. ⟨10.1038/s41598-022-19455-3⟩ Article dans une revue hal-03790880v1
The Administration Matrix Modifies the Beneficial Properties of a Probiotic Mix of Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus acidophilus LA-5 Gréta Pápai,Edgar Torres-Maravilla,Florian Chain,Éva Varga-Visi,Otília Antalet al. Probiotics and Antimicrobial Proteins, 2021, 13 (2), pp. 484-494. ⟨10.1007/s12602-020-09702-2⟩ Article dans une revue hal-03793769v1
The Keystone commensal bacterium Christensenella minuta DSM 22607 displays anti-inflammatory properties both in vitro and in vivo Camille Kropp,Katy Le Corf,Karima Relizani,Kevin Tambosco,Ccori Martinezet al. Scientific Reports, 2021, 11 (1), pp.11494. ⟨10.1038/s41598-021-90885-1⟩ Article dans une revue hal-03793766v1
Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime Q. Leyrolle,F. Decoeur,G. Briere,C. Amadieu,A. Quadroset al. Neuropsychopharmacology, 2021, 46 (3), pp.579-602. ⟨10.1038/s41386-020-00793-7⟩ Article dans une revue hal-02916329v1
Age-related changes in the gut microbiota modify brain lipid composition Mayssa Albouery,Bénédicte Buteau,Stéphane Grégoire,Claire Cherbuy,Jean-Paul Pais de Barroset al. Frontiers in Cellular and Infection Microbiology, 2020, 9, pp.444. ⟨10.3389/fcimb.2019.00444⟩ Article dans une revue hal-02622034v1
Capsular Polysaccharide Cross-Regulation Modulates Bacteroides thetaiotaomicron Biofilm Formation Nathalie Béchon,Jovana Mihajlovic,Sol Vendrell-Fernández,Florian Chain,Philippe Langellaet al. mBio, 2020, 11 (3), ⟨10.1128/mBio.00729-20⟩ Article dans une revue pasteur-03209304v1
Butyrate mediates anti-inflammatory effects of Faecalibacterium prausnitzii in intestinal epithelial cells through Dact3 Marion Lenoir,Rebeca Martín,Edgar Torres-Maravilla,Sead Chadi,Pamela González-Dávilaet al. Gut microbes, 2020, 12 (1), pp.1826748. ⟨10.1080/19490976.2020.1826748⟩ Article dans une revue hal-03339765v1
The potential probiotic &lt;em&gt;lactobacillus rhamnosus&lt;/em&gt; CNCM 1-3690 strain protects the intestinal barrier by stimulating both mucus production and cytoprotective response Rebeca Martin Rosique,Celia Chamignon,Nadia Mhedbi-Hajri,Florian Chain,Muriel Derrienet al. Scientific Reports, 2019, 9, pp.1-14. ⟨10.1038/s41598-019-41738-5⟩ Article dans une revue hal-02627418v1
Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity Brandon D Kayser,Marie Lhomme,Edi Prifti,Carla da Cunha,Florian Marquetet al. FASEB Journal, 2019, 33 (4), pp.4741-4754. ⟨10.1096/fj.201801897R⟩ Article dans une revue hal-02135899v1
The commensal Escherichia coli CEC15 reinforces intestinal defences in gnotobiotic mice and is protective in a chronic colitis mouse model Unai Escribano-Vazquez,Sophie Verstraeten,Rebeca Martin,Florian Chain,Philippe Langellaet al. Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-47611-9⟩ Article dans une revue hal-03033617v1
Elucidating the immune-related mechanisms by which probiotic strain &lt;em&gt;lactobacillus case&lt;/em&gt;i bl23 displays anti-tumoral properties Elsa Jacouton,Marie-Laure Michel,Edgar Torres-Mara Villa,Florian Chain,Philippe Langellaet al. Frontiers in Microbiology, 2019, 9, pp.1-10. ⟨10.3389/fmicb.2018.03281⟩ Article dans une revue hal-02618622v1
Anti-tumoral Effects of Recombinant &lt;em&gt;Lactococcus lactis&lt;/em&gt; Strain Secreting IL-17A Cytokine Elsa Jacouton,Edgar Torres Maravilla,Anne-Sophie Boucard,Nicolas Pouderous,Ana Paula Pessoa Vilelaet al. Frontiers in Microbiology, 2019, 9, ⟨10.3389/fmicb.2018.03355⟩ Article dans une revue hal-02620529v1
Oral delivery of pancreatitis‐associated protein by Lactococcus lactis displays protective effects in dnbs‐induced colitis model and is able to modulate the composition of the microbiota Natalia Martins Breyner,Priscilla Carolinne Bagano Vilas Boas,Gabriel Fernandes,Rodrigo D Carvalho,Tatiana Rochatet al. Environmental Microbiology, 2019, 21 (11), pp. 4020-4031. ⟨10.1111/1462-2920.14748⟩ Article dans une revue hal-02619641v1
A Putative Type V Pilus Contributes to Bacteroides thetaiotaomicron Biofilm Formation Capacity Jovana Mihajlovic,Nathalie Bechon,Christa Ivanova,Florian Chain,Alexandre Almeidaet al. Journal of Bacteriology, 2019, 201 (18), pp.e00650-18. ⟨10.1128/JB.00650-18⟩ Article dans une revue pasteur-02558491v1
A Versatile New Model of Chemically Induced Chronic Colitis Using an Outbred Murine Strain Monica Barone,Florian Chain,Harry Sokol,Patrizia Brigidi,Luis G Bermúdez-Humaránet al. Frontiers in Microbiology, 2018, 9, pp.565. ⟨10.3389/fmicb.2018.00565⟩ Article dans une revue hal-01768628v1
Characterization of a prophage-free derivative strain of &lt;em&gt;Lactococcus lactis&lt;/em&gt; ssp &lt;em&gt;lactis&lt;/em&gt; IL1403 reveals the importance of prophages for phenotypic plasticity of the host Anne Aucouturier,Florian Chain,Philippe Langella,Elena Bidnenko Frontiers in Microbiology, 2018, 9, ⟨10.3389/fmicb.2018.02032⟩ Article dans une revue hal-02625231v1
A New Bifidobacteria Expression SysTem (BEST) to Produce and Deliver Interleukin-10 in Bifidobacterium bifidum Aurélie Mauras,Florian Chain,Aurélie Faucheux,Pauline Ruffié,Sophie Gontieret al. Frontiers in Microbiology, 2018, 9, pp.1-12. ⟨10.3389/fmicb.2018.03075⟩ Article dans une revue hal-02126568v1
The subdominante microbiota member &lt;em&gt;Escherichia Coli&lt;/em&gt; is protective in a chronic inflammatory model with a reinforcement of the intestinal barrier Unai Escribano Vazquez,Sophie Verstraeten,Rebeca Martin Rosique,Florian Chain,Philippe Langellaet al. Gastroenterology, 2018, 154 (6), pp.S-861-S-862. ⟨10.1016/S0016-5085(18)32913-5⟩ Article dans une revue hal-02620530v1
New Insights into the Diversity of the Genus Faecalibacterium Leandro Benevides,Sriti Burman,Rebeca Martin,Véronique Robert,Muriel Thomaset al. Frontiers in Microbiology, 2017, 8, pp.1790. ⟨10.3389/fmicb.2017.01790⟩ Article dans une revue hal-01617957v1
Contribution of plasmid-encoded peptidase S8 (PrtP) to adhesion and transit in the gut of Lactococcus lactis IBB477 strain Joanna Maria Radziwill-Bienkowska,Véronique Robert,Karolina Drabot,Florian Chain,Claire Cherbuyet al. Applied Microbiology and Biotechnology, 2017, 101 (14), pp.5709-5721. ⟨10.1007/s00253-017-8334-1⟩ Article dans une revue hal-01605918v1
Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii Shows a Protective Effect on DNBS and DSS-Induced Colitis Model in Mice through Inhibition of NF-kappa B Pathway Natalia Martins Breyner,Christophe Michon,Cassiana S. de Sousa,Priscilla Carolinne Bagano Vilas Boas,Florian Chainet al. Frontiers in Microbiology, 2017, 8, ⟨10.3389/fmicb.2017.00114⟩ Article dans une revue hal-01604976v1
A Cell-Penetrant Manganese SOD-Mimic Is Able To Complement MnSOD and Exerts an Antiinflammatory Effect on Cellular and Animal Models of Inflammatory Bowel Diseases Emilie Mathieu,Anne-Sophie Bernard,Nicolas Delsuc,Elodie Quévrain,Géraldine Gazzahet al. Inorganic Chemistry, 2017, 56 (5), pp.2545-2555. ⟨10.1021/acs.inorgchem.6b02695⟩ Article dans une revue hal-01473825v1
Using murine colitis models to analyze probiotics–host interactions Rebeca Martin Rosique,Florian Chain,Sylvie Miquel,Jean-Paul Motta,Nathalie Vergnolleet al. FEMS Microbiology Reviews, 2017, 41 (Supp_1), pp.S49-S70. ⟨10.1093/femsre/fux035⟩ Article dans une revue (article de synthèse) hal-01602302v1
Probiotic Strain Lactobacillus casei BL23 Prevents Colitis-Associated Colorectal Cancer Elsa Jacouton,Florian Chain,Harry Sokol,Philippe Langella,Luis G. Bermudez-Humaran Frontiers in Immunology, 2017, 8, pp.1553. ⟨10.3389/fimmu.2017.01553⟩ Article dans une revue hal-01654633v1
Functional characterization of novel &lt;em&gt;Faecalibacterium prausnitzii&lt;/em&gt; strains isolated from healthy volunteers: a step forward in the use of &lt;em&gt;F. prausnitzii&lt;/em&gt; as a next-generation probiotic Rebeca Martín,Sylvie S. Miquel,Leandro Benevides,Chantal Bridonneau,Véronique Robertet al. Frontiers in Microbiology, 2017, 8, ⟨10.3389/fmicb.2017.01226⟩ Article dans une revue hal-02629302v1
Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria Jean-Guy Leblanc,Florian Chain,Rebeca Martin Rosique,Luis Bermudez Humaran,Stéphanie Courauet al. Microbial Cell Factories, 2017, 16, ⟨10.1186/s12934-017-0691-z⟩ Article dans une revue hal-01607301v1
Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses Oriana Rossi,Lisette A. van Berkel,Florian Chain,M. Tanweer Khan,Nico Taverneet al. Scientific Reports, 2016, 6 (4), pp.18507. ⟨10.1038/srep18507⟩ Article dans une revue hal-01306730v1
Bifidobacterium animalis ssp. lactis CNCM-I2494 Restores Gut Barrier Permeability in Chronically Low-Grade Inflamed Mice Rebeca Martín,Laure Laval,Florian Chain,Sylvie Miquel,Jane Natividadet al. Frontiers in Microbiology, 2016, 7, pp.608. ⟨10.3389/fmicb.2016.00608⟩ Article dans une revue hal-01323776v1
Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease E. Quévrain,M.A. Maubert,C. Michon,F. Chain,R. Marquantet al. Gut, 2016, 65 (3), pp.415-425. ⟨10.1136/gutjnl-2014-307649⟩ Article dans une revue hal-02046235v1
Protective effect of TSLP delivered at the gut mucosa level by recombinant lactic acid bacteria in DSS-induced colitis mouse model (vol 14, 176, 2015) Camille Aubry,Christophe Michon,Florian Chain,Yolande Chvatchko,Laurence Goffinet al. Microbial Cell Factories, 2016, 15, pp.1. ⟨10.1186/s12934-016-0592-6⟩ Article dans une revue hal-01602860v1
A large scale in vitro screening of Streptococcus thermophilus strains revealed strains with a high anti-inflammatory potential Maira Junjua,Noura Kechaou,Florian Chain,Ahoefa Ablavi Awussi,Yvonne Rousselet al. LWT - Food Science and Technology, 2016, 70, pp.78-87. ⟨10.1016/j.lwt.2016.02.006⟩ Article dans une revue istex hal-01329215v1
Drying process strongly affects probiotics viability and functionalities Cyril Iaconelli,Guillaume Lemetais,Noura Kechaou,Florian Chain,Luis Bermúdez-Humaránet al. African Journal of Biotechnology, 2015, 214, pp.17-26. ⟨10.1016/j.jbiotec.2015.08.022⟩ Article dans une revue istex hal-02292051v1
Protective effect of TSLP delivered at the gut mucosa level by recombinant lactic acid bacteria in DSS-induced colitis mouse model Camille C. Aubry,Christophe Michon,Florian Chain,Yolande Chvatchko,Laurence Goffinet al. Microbial Cell Factories, 2015, 14, ⟨10.1186/s12934-015-0367-5⟩ Article dans une revue hal-02634613v1
Identification of Metabolic Signatures Linked to Anti-Inflammatory Effects of Faecalibacterium prausnitzii Sylvie Miquel,Marion Leclerc,Rebeca Martin,Florian Chain,Marion Lenoiret al. mBio, 2015, 6 (2), pp.e00300-15. ⟨10.1128/mBio.00300-15⟩ Article dans une revue hal-01226343v1
Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model Rebeca Martin,Sylvie Miquel,Florian Chain,Jane M. Natividad,Jennifer Juryet al. BMC Microbiology, 2015, 15, pp.67. ⟨10.1186/s12866-015-0400-1⟩ Article dans une revue hal-01376844v1
Genetically Engineered Immunomodulatory Streptococcus thermophilus Strains Producing Antioxidant Enzymes Exhibit Enhanced AntiInflammatory Activities Silvina del Carmen,Alejandra de Moreno de Leblanc,Rebeca Martin,Florian Chain,Philippe Langellaet al. Applied and Environmental Microbiology, 2014, 80 (3), pp.869 - 877. ⟨10.1128/AEM.03296-13⟩ Article dans une revue hal-01204435v1
Effects in the use of a genetically engineered strain of Lactococcus lactis delivering in situ IL-10 as a therapy to treat low-grade colon inflammation. Rebeca Martín,Florian Chain,Sylvie Miquel,Jane M Natividad,Harry Sokolet al. Human Vaccines & Immunotherapeutics, 2014, 10 (6), pp.1611-1621. ⟨10.4161/hv.28549⟩ Article dans une revue hal-00979468v1
Faecalibacterium prausnitzii prevents irritable bowel syndrome-like symptoms in both murine low grade chronic inflammation and acute stress models Rebeca Martin Rosique,Sylvie S. Miquel,Florian Chain,Jane Mea Natividad,Marion Gilletet al. Gastroenterology, 2014, 146 (5), pp.S-840-S-841. ⟨10.1016/S0016-5085(14)63054-7⟩ Article dans une revue hal-02629578v1
The dual role of MAPK pathway in the regulation of intestinal barrier: the role of the commensal bacterium [i]Faecalibacterium prausnitzi[/i]i on this regulation. Reply Rebeca Martin Rosique,Marion Lenoir,Florian Chain,Philippe Langella,Luis Bermudez Humaran Inflammatory Bowel Diseases, 2014, 20 (7), pp.E17-E18. ⟨10.1097/MIB.0000000000000070⟩ Article dans une revue hal-01204386v1
Lactobacillus rhamnosus CNCM I-3690 and the commensal bacterium Faecalibacterium prausnitzii A2-165 exhibit similar protective effects to induced barrier hyper-permeability in mice. L Laval,R Martin,J N Natividad,F Chain,S Miquelet al. Gut microbes, 2014, 6 (1), pp.1-9. ⟨10.4161/19490976.2014.990784⟩ Article dans une revue hal-01097182v1
The Commensal Bacterium Faecalibacterium prausnitzii Is Protective in DNBS-induced Chronic Moderate and Severe Colitis Models. Rebeca Martín,Florian Chain,Sylvie Miquel,Jun Lu,Jean-Jacques Gratadouxet al. Inflammatory Bowel Diseases, 2014, 20 (3), pp.417-430. ⟨10.1097/01.MIB.0000440815.76627.64⟩ Article dans une revue hal-00931932v1
Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening Noura N. Kechaou,Florian Chain,Jean-Jacques J.-J. Gratadoux,Sébastien Blugeon,Nicolas N. Berthoet al. Applied and Environmental Microbiology, 2013, 79 (5), pp.1491 - 1499. ⟨10.1128/AEM.03075-12⟩ Article dans une revue hal-01001569v1
A single-stranded conformational polymorphism (SSCP)-derived quantitative variable to monitor the virulence of a Barley yellow dwarf virus-PAV (BYDV-PAV) isolate during adaptation to the TC14 resistant wheat line Agnès Delaunay,Christelle Lacroix,Stéphanie Morliere,Gerard Riault,Florian Chainet al. Molecular Plant Pathology, 2010, 11 (5), pp.651-661. ⟨10.1111/J.1364-3703.2010.00635.X⟩ Article dans une revue hal-02658708v1
Evaluation of the durability of the Barley yellow dwarf virus-resistant Zhong ZH and TC14 wheat lines Florian Chain,Gerard Riault,Maxime M. Trottet,Emmanuel Jacquot European Journal of Plant Pathology, 2007, 117 (1), pp.35-43. ⟨10.1007/s10658-006-9066-8⟩ Article dans une revue istex hal-02658529v1
Field trial of serially passaged isolates of BYDV-PAV overcoming resistance derived from Thinopyrum intermedium in wheat Florian Chain,Gerard Riault,Emmanuel Jacquot,Maxime M. Trottet Plant Breeding, 2006, 125 (3), pp.211-216. ⟨10.1111/j.1439-0523.2006.01210.x⟩ Article dans une revue istex hal-02656357v1
Analysis of accumulation patterns of Barley yellow dwarf virus-PAV (BYDV-PAV) in two resistant wheat lines Florian Chain,Gerard Riault,Maxime M. Trottet,Emmanuel Jacquot European Journal of Plant Pathology, 2005, 113 (4), pp.343-355. ⟨10.1007/s10658-005-7966-7⟩ Article dans une revue istex hal-02675841v1
Characterization of two sources of tolerance/resistance to Barley yellow dwarf virus-PAV (BYDV-PAV) in wheat and estimation of their durability using serial passage experiment procedures Florian Chain,Gerard Riault,Maxime M. Trottet,Emmanuel Jacquot Parasitica, 2005, 61 (1), pp.41-46 Article dans une revue hal-02673723v1