Franck Mortreux

25
Documents

Présentation

My research career is dedicated to investigating the molecular mechanisms that regulate leukemogenic processes during the infection by HTLV-1, the causative agent of adult T-cell leukemia/lymphoma (ATLL) and various inflammatory diseases. I initiated these investigations during my PhD under the supervision of Eric Wattel at the Institut de Recherche sur le Cancer de Lille (IRCL, France), where we made significant contributions to understanding HTLV-1 replication through clonal expansion and its association with cellular genomic instability. I furthered my research during my postdoctoral internship at FUSAgs Gembloux (Belgium), where I extended my investigations to the Bovine Leukemia Virus.

In 2002, I joined INSERM and established my own research group within the Centre Léon Bérard (CRCL) in Lyon, France, collaborating closely with E. Wattel. During this period, I focused on exploring the molecular mechanisms underlying viral persistence, particularly HTLV-1 and other deltaretroviruses like HTLV-II and BLV. Our studies provided insights into how these viruses manipulate cellular processes and reprogram gene expression, with a specific focus on the transcriptional changes associated with telomere maintenance.

In 2011, I transferred my research group to the Laboratory of Biology and Modeling of the Cell (LBMC) at ENS-Lyon. Here, we expanded our investigations to include post-transcriptional regulations induced by HTLV-1 infection, such as miRNA expression patterns and alternative splicing of coding and non-coding RNAs. Additionally, I collaborated with the Hospices Civils de Lyon on translational research, where we identified alternative splicing modifications as potential prognostic markers in acute myeloblastic leukemia.

Methodologically, we employed various approaches to address our research questions, including limited-dilution cloning of primary T-CD4+ cells, large-scale analysis of gene expression at the transcript and exon levels, miRNA quantification using chips and TLDA assays, mass spectrometry analysis of transcription factors through DNA affinity precipitation assays (DAPA), and more recently, the investigation of changes in 3D chromatin conformation using techniques like Hi-C, 3C, and 4C.

Currently, my research is dedicated to unraveling the molecular mechanisms that connect chromatin topology to alternative splicing decisions, specifically in the synthesis of linear and circular RNA isoforms during HTLV-1-associated leukemogenesis. These ongoing investigations aim to deepen our understanding of the complex interplay between chromatin organization and post-transcriptional regulations, with the ultimate goal of advancing our knowledge of HTLV-1-related pathologies.

Domaines de recherche

Sciences du Vivant [q-bio]

Publications

Publications

Image document

Gene-to-gene coordinated regulation of transcription and alternative splicing by 3D chromatin remodeling upon NF-κB activation

Paul Marie , Matéo Bazire , Julien Ladet , Lamya Ben Ameur , Sanjay Chahar et al.
Nucleic Acids Research, 2024, 52 (4), pp.1527-1543. ⟨10.1093/nar/gkae015⟩
Article dans une revue inserm-04830003 v1
Image document

Peculiar transcriptional reprogramming with functional impairment of dendritic cells upon exposure to transformed HTLV-1-infected cells

Auriane Carcone , Franck Mortreux , Sandrine Alais , Cyrille Mathieu , Chloé Journo et al.
PLoS Pathogens, 2024, 20 (9), pp.e1012555. ⟨10.1371/journal.ppat.1012555⟩
Article dans une revue hal-04743334 v2

Induction of tolerogenicity following a molecular dialogue between HTLV-1-infected T cells and dendritic cells

Hélène Dutartre , Auriane Carcone , Franck Mortreux , Sandrine Alais , Cyrille Mathieu et al.
Research Square - Preprint, 2024, ⟨10.21203/rs.3.rs-4413764/v1⟩
Article dans une revue hal-04743166 v1
Image document

A homozygous mutation in the human selenocysteine tRNA gene impairs UGA recoding activity and selenoproteome regulation by selenium

Caroline Vindry , Olivia Guillin , Philippe Wolff , Paul Marie , Franck Mortreux et al.
Nucleic Acids Research, 2023, ⟨10.1093/nar/gkad482⟩
Article dans une revue hal-04136959 v1

Prognostic impact of ABCA3 expression in adult and pediatric acute myeloid leukemia: an ALFA-ELAM02 joint study

Antony Ceraulo , Hélène Lapillonne , Meyling Cheok , Claude Preudhomme , Hervé Dombret et al.
Blood Advances, 2022, 6 (9), pp.2773-2777. ⟨10.1182/bloodadvances.2021006040⟩
Article dans une revue hal-04541112 v1

The endogenous HBZ interactome in ATL leukemic cells reveals an unprecedented complexity of host interacting partners involved in RNA splicing

Mariam Shallak , Tiziana Alberio , Mauro Fasano , Maria Monti , Ilaria Iacobucci et al.
Frontiers in Immunology, 2022, 13 (14), pp.7580-7601. ⟨10.3389/fimmu.2022.939863⟩
Article dans une revue hal-04880270 v1
Image document

RNA helicase-dependent gene looping impacts messenger RNA processing

Sophie Terrone , Jessica Valat , Nicolas Fontrodona , Guillaume Giraud , Jean-Baptiste Claude et al.
Nucleic Acids Research, 2022, 50 (16), pp.9226-9246. ⟨10.1093/nar/gkac717⟩
Article dans une revue hal-03842696 v1
Image document

The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape

Charlotte Vandermeulen , Tina O’grady , Jerome Wayet , Bartimee Galvan , Sibusiso Maseko et al.
PLoS Pathogens, 2021, 17 (9), pp.e1009919. ⟨10.1371/journal.ppat.1009919⟩
Article dans une revue hal-03400504 v1
Image document

Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1

Lamya Ben Ameur , Paul Marie , Morgan Thénoz , Guillaume Giraud , Emmanuel Combe et al.
Nature Communications, 2020, 11 (1), pp.3045. ⟨10.1038/s41467-020-16853-x⟩
Article dans une revue inserm-02877333 v1

Les ARN circulaires, acteurs et biomarqueurs dans le cancer

Julien Ladet , Franck Mortreux
Médecine/Sciences, 2020, 36 (10), pp.935-938. ⟨10.1051/medsci/2020165⟩
Article dans une revue hal-04880284 v1

An miRNA–DNMT1 Axis Is Involved in Azacitidine Resistance and Predicts Survival in Higher-Risk Myelodysplastic Syndrome and Low Blast Count Acute Myeloid Leukemia

Françoise Solly , Catherine Koering , Aminetou Mint Mohamed , Delphine Maucort-Boulch , Guillaume Robert et al.
Clinical Cancer Research, 2017, 23 (12), pp.3025-3034. ⟨10.1158/1078-0432.CCR-16-2304⟩
Article dans une revue hal-04152040 v1

TET2 exon 2 skipping is an independent favorable prognostic factor for cytogenetically normal acute myelogenous leukemia (AML)

Aminetou Mint Mohamed , Marie Balsat , Catherine Koering , Delphine Maucort-Boulch , Nicolas Boissel et al.
Leukemia Research, 2017, 56, pp.21-28. ⟨10.1016/j.leukres.2017.01.012⟩
Article dans une revue hal-04542985 v1

TET2 exon 2 skipping is an independent favorable prognostic factor for cytogenetically normal acute myelogenous leukemia (AML)

Aminetou Mint Mohamed , Marie Balsat , Catherine Koering , Delphine Maucort-Boulch , Nicolas Boissel et al.
Leukemia Research, 2017, 56 (1), pp.21-28. ⟨10.1016/j.leukres.2017.01.012⟩
Article dans une revue hal-04152030 v1
Image document

Adult T-Cell Leukemia/Lymphoma in a Caucasian Patient After Sexual Transmission of Human T-Cell Lymphotropic Virus Type 1.

David Sibon , Olivier Cassar , Isabelle Duga , Chantal Brouzes , David Ghez et al.
Open Forum Infectious Diseases, 2015, 2 (2), pp.ofv032. ⟨10.1093/ofid/ofv032⟩
Article dans une revue pasteur-01370931 v1

HTLV-1 bZIP Factor HBZ Promotes Cell Proliferation and Genetic Instability by Activating OncomiRs

Céline Vernin , Morgan Thenoz , Christiane Pinatel , A. Gessain , O. Gout et al.
Cancer Research, 2014, 74 (21), pp.6082-6093. ⟨10.1158/0008-5472.CAN-13-3564⟩
Article dans une revue hal-02487471 v1
Image document

Cause-specific telomere factors deregulation in hepatocellular carcinoma.

Manale El Idrissi , Valérie Hervieu , Philippe Merle , Franck Mortreux , Eric Wattel
Journal of Experimental and Clinical Cancer Research, 2013, 32 (1), pp.64. ⟨10.1186/1756-9966-32-64⟩
Article dans une revue inserm-00869683 v1

HTLV-1-associated inflammatory myopathies: low proviral load and moderate inflammation in 13 patients from West Indies and West Africa.

Marion Desdouits , Olivier Cassar , Thierry Maisonobe , Alexandra Desrames , Achille Aouba et al.
Journal of Clinical Virology, 2013, 57 (1), pp.70-6. ⟨10.1016/j.jcv.2012.12.016⟩
Article dans une revue istex pasteur-01370950 v1
Image document

Antiretroviral therapy promotes an inflammatory-like pattern of human T-cell lymphotropic virus type 1 (HTLV-1) replication in human immunodeficiency virus type 1/HTLV-1 co-infected individuals.

Carole Pomier , Samira Rabaaoui , Jean-François Pouliquen , Pierre Couppié , Myriam El Guedj et al.
Journal of General Virology, 2013, 94 (Pt 4), pp.753-7. ⟨10.1099/vir.0.048348-0⟩
Article dans une revue pasteur-00861805 v1

Telomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias.

Valérie Capraro , Linda Zane , Delphine Poncet , David Pérol , Perrine Galia et al.
Experimental Hematology, 2011, 39 (2), pp.195-202.e2. ⟨10.1016/j.exphem.2010.10.008⟩
Article dans une revue hal-00787970 v1
Image document

Highly active antiretroviral treatment against STLV-1 infection combining reverse transcriptase and HDAC inhibitors.

Philippe V Afonso , Mourad Mekaouche , Franck Mortreux , Frédéric Toulza , Antoine Moriceau et al.
Blood, 2010, 116 (19), pp.3802-8. ⟨10.1182/blood-2010-02-270751⟩
Article dans une revue pasteur-00507417 v1

Clonal expansion of HTLV-1 positive CD8+ cells relies on cIAP-2 but not on c-FLIP expression.

Linda Zane , David Sibon , Catherine Legras , Joël Lachuer , Anne Wierinckx et al.
Virology, 2010, 407 (2), pp.341-51. ⟨10.1016/j.virol.2010.07.023⟩
Article dans une revue pasteur-00530129 v1
Image document

Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo.

Linda Zane , David Sibon , Lionel Jeannin , Marc Zandecki , Marie-Hélène Delfau-Larue et al.
Retrovirology, 2010, 7, pp.17. ⟨10.1186/1742-4690-7-17⟩
Article dans une revue pasteur-00488306 v1

Cell dynamics and immune response to BLV infection: a unifying model

Arnaud Florins , Nicolas Gillet , Becca Asquith , Mathieu Boxus , Catherine Burteau et al.
Frontiers in Bioscience, 2007, 12, pp.1520-1531
Article dans une revue hal-02664896 v1

Somatic mutation in human T-cell leukemia virus type 1 provirus and flanking cellular sequences during clonal expansion in vivo

Franck Mortreux , I. Leclercq , As Gabet , A. Leroy , E. Westhof et al.
JNCI: Journal of the National Cancer Institute, 2001, 93 (5), pp.367-77. ⟨10.1093/jnci/93.5.367⟩
Article dans une revue istex hal-00117199 v1