Franck Mortreux

Présentation

My research career is dedicated to investigating the molecular mechanisms that regulate leukemogenic processes during the infection by HTLV-1, the causative agent of adult T-cell leukemia/lymphoma (ATLL) and various inflammatory diseases. I initiated these investigations during my PhD under the supervision of Eric Wattel at the Institut de Recherche sur le Cancer de Lille (IRCL, France), where we made significant contributions to understanding HTLV-1 replication through clonal expansion and its association with cellular genomic instability. I furthered my research during my postdoctoral internship at FUSAgs Gembloux (Belgium), where I extended my investigations to the Bovine Leukemia Virus.

In 2002, I joined INSERM and established my own research group within the Centre Léon Bérard (CRCL) in Lyon, France, collaborating closely with E. Wattel. During this period, I focused on exploring the molecular mechanisms underlying viral persistence, particularly HTLV-1 and other deltaretroviruses like HTLV-II and BLV. Our studies provided insights into how these viruses manipulate cellular processes and reprogram gene expression, with a specific focus on the transcriptional changes associated with telomere maintenance.

In 2011, I transferred my research group to the Laboratory of Biology and Modeling of the Cell (LBMC) at ENS-Lyon. Here, we expanded our investigations to include post-transcriptional regulations induced by HTLV-1 infection, such as miRNA expression patterns and alternative splicing of coding and non-coding RNAs. Additionally, I collaborated with the Hospices Civils de Lyon on translational research, where we identified alternative splicing modifications as potential prognostic markers in acute myeloblastic leukemia.

Methodologically, we employed various approaches to address our research questions, including limited-dilution cloning of primary T-CD4+ cells, large-scale analysis of gene expression at the transcript and exon levels, miRNA quantification using chips and TLDA assays, mass spectrometry analysis of transcription factors through DNA affinity precipitation assays (DAPA), and more recently, the investigation of changes in 3D chromatin conformation using techniques like Hi-C, 3C, and 4C.

Currently, my research is dedicated to unraveling the molecular mechanisms that connect chromatin topology to alternative splicing decisions, specifically in the synthesis of linear and circular RNA isoforms during HTLV-1-associated leukemogenesis. These ongoing investigations aim to deepen our understanding of the complex interplay between chromatin organization and post-transcriptional regulations, with the ultimate goal of advancing our knowledge of HTLV-1-related pathologies.

Publications

Article dans une revue (24)

Peculiar transcriptional reprogramming with functional impairment of dendritic cells upon exposure to transformed HTLV-1-infected cells Auriane Carcone,Franck Mortreux,Sandrine Alais,Cyrille Mathieu,Chloé Journoet al. PLoS Pathogens, 2024, 20 (9), pp.e1012555. ⟨10.1371/journal.ppat.1012555⟩ Article dans une revue hal-04743334v2
Gene-to-gene coordinated regulation of transcription and alternative splicing by 3D chromatin remodeling upon NF-κB activation Paul Marie,Matéo Bazire,Julien Ladet,Lamya Ben Ameur,Sanjay Chaharet al. Nucleic Acids Research, 2024, 52 (4), pp.1527-1543. ⟨10.1093/nar/gkae015⟩ Article dans une revue inserm-04830003v1
Induction of tolerogenicity following a molecular dialogue between HTLV-1-infected T cells and dendritic cells Hélène Dutartre,Auriane Carcone,Franck Mortreux,Sandrine Alais,Cyrille Mathieuet al. Research Square - Preprint, 2024, ⟨10.21203/rs.3.rs-4413764/v1⟩ Article dans une revue hal-04743166v1
A homozygous mutation in the human selenocysteine tRNA gene impairs UGA recoding activity and selenoproteome regulation by selenium Caroline Vindry,Olivia Guillin,Philippe Wolff,Paul Marie,Franck Mortreuxet al. Nucleic Acids Research, 2023, 51 (14), pp.7580-7601. ⟨10.1093/nar/gkad482⟩ Article dans une revue hal-04136959v1
The endogenous HBZ interactome in ATL leukemic cells reveals an unprecedented complexity of host interacting partners involved in RNA splicing Mariam Shallak,Tiziana Alberio,Mauro Fasano,Maria Monti,Ilaria Iacobucciet al. Frontiers in Immunology, 2022, 13 (14), pp.7580-7601. ⟨10.3389/fimmu.2022.939863⟩ Article dans une revue hal-04880270v1
Prognostic impact of ABCA3 expression in adult and pediatric acute myeloid leukemia: an ALFA-ELAM02 joint study Antony Ceraulo,Hélène Lapillonne,Meyling Cheok,Claude Preudhomme,Hervé Dombretet al. Blood Advances, 2022, 6 (9), pp.2773-2777. ⟨10.1182/bloodadvances.2021006040⟩ Article dans une revue hal-04541112v1
RNA helicase-dependent gene looping impacts messenger RNA processing Sophie Terrone,Jessica Valat,Nicolas Fontrodona,Guillaume Giraud,Jean-Baptiste Claudeet al. Nucleic Acids Research, 2022, 50 (16), pp.9226-9246. ⟨10.1093/nar/gkac717⟩ Article dans une revue hal-03842696v1
The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape Charlotte Vandermeulen,Tina O’grady,Jerome Wayet,Bartimee Galvan,Sibusiso Masekoet al. PLoS Pathogens, 2021, 17 (9), pp.e1009919. ⟨10.1371/journal.ppat.1009919⟩ Article dans une revue hal-03400504v1
Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1 Lamya Ben Ameur,Paul Marie,Morgan Thénoz,Guillaume Giraud,Emmanuel Combeet al. Nature Communications, 2020, 11 (1), pp.3045. ⟨10.1038/s41467-020-16853-x⟩ Article dans une revue inserm-02877333v1
Les ARN circulaires, acteurs et biomarqueurs dans le cancer Julien Ladet,Franck Mortreux Médecine/Sciences, 2020, 36 (10), pp.935-938. ⟨10.1051/medsci/2020165⟩ Article dans une revue hal-04880284v1
An miRNA–DNMT1 Axis Is Involved in Azacitidine Resistance and Predicts Survival in Higher-Risk Myelodysplastic Syndrome and Low Blast Count Acute Myeloid Leukemia Françoise Solly,Catherine Koering,Aminetou Mint Mohamed,Delphine Maucort-Boulch,Guillaume Robertet al. Clinical Cancer Research, 2017, 23 (12), pp.3025-3034. ⟨10.1158/1078-0432.CCR-16-2304⟩ Article dans une revue hal-04152040v1
TET2 exon 2 skipping is an independent favorable prognostic factor for cytogenetically normal acute myelogenous leukemia (AML) Aminetou Mint Mohamed,Marie Balsat,Catherine Koering,Delphine Maucort-Boulch,Nicolas Boisselet al. Leukemia Research, 2017, 56, pp.21-28. ⟨10.1016/j.leukres.2017.01.012⟩ Article dans une revue hal-04542985v1
TET2 exon 2 skipping is an independent favorable prognostic factor for cytogenetically normal acute myelogenous leukemia (AML) Aminetou Mint Mohamed,Marie Balsat,Catherine Koering,Delphine Maucort-Boulch,Nicolas Boisselet al. Leukemia Research, 2017, 56 (1), pp.21-28. ⟨10.1016/j.leukres.2017.01.012⟩ Article dans une revue hal-04152030v1
Adult T-Cell Leukemia/Lymphoma in a Caucasian Patient After Sexual Transmission of Human T-Cell Lymphotropic Virus Type 1. David Sibon,Olivier Cassar,Isabelle Duga,Chantal Brouzes,David Ghezet al. Open Forum Infectious Diseases, 2015, 2 (2), pp.ofv032. ⟨10.1093/ofid/ofv032⟩ Article dans une revue pasteur-01370931v1
HTLV-1 bZIP Factor HBZ Promotes Cell Proliferation and Genetic Instability by Activating OncomiRs Céline Vernin,Morgan Thenoz,Christiane Pinatel,A. Gessain,O. Goutet al. Cancer Research, 2014, 74 (21), pp.6082-6093. ⟨10.1158/0008-5472.CAN-13-3564⟩ Article dans une revue hal-02487471v1
Cause-specific telomere factors deregulation in hepatocellular carcinoma. Manale El Idrissi,Valérie Hervieu,Philippe Merle,Franck Mortreux,Eric Wattel Journal of Experimental and Clinical Cancer Research, 2013, 32 (1), pp.64. ⟨10.1186/1756-9966-32-64⟩ Article dans une revue inserm-00869683v1
HTLV-1-associated inflammatory myopathies: low proviral load and moderate inflammation in 13 patients from West Indies and West Africa. Marion Desdouits,Olivier Cassar,Thierry Maisonobe,Alexandra Desrames,Achille Aoubaet al. Journal of Clinical Virology, 2013, 57 (1), pp.70-6. ⟨10.1016/j.jcv.2012.12.016⟩ Article dans une revue istex pasteur-01370950v1
Antiretroviral therapy promotes an inflammatory-like pattern of human T-cell lymphotropic virus type 1 (HTLV-1) replication in human immunodeficiency virus type 1/HTLV-1 co-infected individuals. Carole Pomier,Samira Rabaaoui,Jean-François Pouliquen,Pierre Couppié,Myriam El Guedjet al. Journal of General Virology, 2013, 94 (Pt 4), pp.753-7. ⟨10.1099/vir.0.048348-0⟩ Article dans une revue pasteur-00861805v1
Telomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias. Valérie Capraro,Linda Zane,Delphine Poncet,David Pérol,Perrine Galiaet al. Experimental Hematology, 2011, 39 (2), pp.195-202.e2. ⟨10.1016/j.exphem.2010.10.008⟩ Article dans une revue hal-00787970v1
Highly active antiretroviral treatment against STLV-1 infection combining reverse transcriptase and HDAC inhibitors. Philippe V Afonso,Mourad Mekaouche,Franck Mortreux,Frédéric Toulza,Antoine Moriceauet al. Blood, 2010, 116 (19), pp.3802-8. ⟨10.1182/blood-2010-02-270751⟩ Article dans une revue pasteur-00507417v1
Clonal expansion of HTLV-1 positive CD8+ cells relies on cIAP-2 but not on c-FLIP expression. Linda Zane,David Sibon,Catherine Legras,Joël Lachuer,Anne Wierinckxet al. Virology, 2010, 407 (2), pp.341-51. ⟨10.1016/j.virol.2010.07.023⟩ Article dans une revue istex pasteur-00530129v1
Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo. Linda Zane,David Sibon,Lionel Jeannin,Marc Zandecki,Marie-Hélène Delfau-Larueet al. Retrovirology, 2010, 7, pp.17. ⟨10.1186/1742-4690-7-17⟩ Article dans une revue pasteur-00488306v1
Cell dynamics and immune response to BLV infection: a unifying model Arnaud Florins,Nicolas Gillet,Becca Asquith,Mathieu Boxus,Catherine Burteauet al. Frontiers in Bioscience, 2007, 12, pp.1520-1531 Article dans une revue hal-02664896v1
Somatic mutation in human T-cell leukemia virus type 1 provirus and flanking cellular sequences during clonal expansion in vivo Franck Mortreux,I. Leclercq,As Gabet,A. Leroy,E. Westhofet al. JNCI: Journal of the National Cancer Institute, 2001, 93 (5), pp.367-77. ⟨10.1093/jnci/93.5.367⟩ Article dans une revue istex hal-00117199v1

Pré-publication, Document de travail (1)

The MYCN oncoprotein and helicases DDX17 and DDX5 have opposite effects on the production of chimeric transcripts in neuroblastoma cells Valentine Clerc,Jessica Valat,Xavier Grand,Nicolas Fontrodona,Matéo Bazireet al. 2024 Pré-publication, Document de travail inserm-04830027v1