François Ferron

Identifiants chercheurs

IdHAL :

francois-ferron

ORCID :

0000-0002-8351-4992

IdRef :

087227290

Publications

Poster de conférence (7)

AIR-MT: AI-based design of RNA Methyltransferases for RNA-based therapeutics Priscila Sutto,Bruno Canard,François Ferron SOLEIL Users' Meeting (SUM2026), Jan 2026, Saint-Aubin, France. Poster de conférence hal-05491018v1
How did you annotate your new viral genome without it ? VAZyMolO-2 Vincent Wilde,Bruno Canard,Francois Ferron ViBioM2024, May 2024, Luven, Belgium Poster de conférence hal-04616074v1
Le complexe nsp14:nsp10 du SARS-CoV-2 stabilisé par un nanobody Pierre Gauffre,Anaïs Gaubert,Maria Mate-Perez,Bruno Canard,François Ferron XXVèmes Journées Francophones de Virologie, Apr 2023, Paris, France. Virologie, 27 (2), pp.48-49, 2023, ⟨10.1684/vir.2023.993⟩ Poster de conférence hal-04246262v1
BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF L POLYMERASE PROTEIN FROM LCMV Candice Sartre,Sergio Hernández,Barbara Selisko,Denis Ptchelkine,Bruno Canardet al. 3rd Integrative Structural Biology Meeting (BSI), Nov 2023, Marseille, France. 2023 Poster de conférence hal-05091533v1
Structural characterisation and inhibition of Arenavirus replication complex elements : assembly, function and inhibition of embedded nucleases Sergio Hernández,Nicolas Papageorgiou,Maria Spiliopoulou,Mikael Feracci,Laura Garlattiet al. 26TH CONGRESS AND GENERAL ASSEMBLY OF THE INTERNATIONAL UNION OF CRYSTALLOGRAPHY, Aug 2023, Melbourne (AUS), Australia Poster de conférence hal-04180334v1
Viral Instant Mutation Viewer (VIMVer): a tool to speed up the identification and analysis of new SARS-CoV2 emerging variant Vincent Wilde,Bruno Canard,Francois Ferron ViBioM 2022, Mar 2022, Valencia, Spain. online Poster de conférence hal-04387599v1
Analyse structurale de la nouvelle N7 guanine-MTase du virus de la Brème bordelière Pierre Gauffre,Ashleigh Shannon,Bhawna Sama,Bruno Canard,François Ferron 23ème Journées Francophones de Virologie, Apr 2021, Paris (en ligne), France. Virologie. 2021;25(1):68-74, 25 (S1), pp.68-74, 2021, ⟨10.1684/vir.2021.0892⟩ Poster de conférence hal-04246230v1

Article dans une revue (44)

Mapping the impact of 1'-, 2'-and 4'-nucleotide modifications on the Respiratory Syncytial Virus RNA-dependent RNA polymerase Priscila Sutto-Ortiz,Barbara Selisko,François Ferron,Jean-Pierre Sommadossi,Adel Moussaet al. Antiviral Research, 2025, ⟨10.1016/j.antiviral.2025.106298⟩ Article dans une revue hal-05313860v1
Neurotoxic Implications of Human Coronaviruses in Neurodegenerative Diseases: A Perspective from Amyloid Aggregation Thi Hong Van Nguyen,Francois Ferron,Kazuma Murakami ACS Chemical Biology, 2025, 20 (5), pp.983-992. ⟨10.1021/acschembio.5c00153⟩ Article dans une revue hal-05378512v1
Derivatives of MOPS : promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition Oney Ortega Granda,Karine Alvarez,Benjamin Morin,Bruno Canard,François Ferronet al. FEBS Journal, 2025, 292 (11), pp.2865-2881. ⟨10.1111/febs.70039⟩ Article dans une revue hal-04988010v1
Structural flexibility of Toscana virus nucleoprotein in the presence of a single-chain camelid antibody Nicolas Papageorgiou,Amal Baklouti,Julie Lichière,Aline Desmyter,Bruno Canardet al. Acta crystallographica Section D : Structural biology [1993-..], 2024, 80 (2), ⟨10.1107/S2059798324000196⟩ Article dans une revue hal-04416977v1
The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution Aurelie Chazot,Claire Zimberger,Mikael Feracci,Adel Moussa,Steven Goodet al. PLoS Biology, 2024, ⟨10.1371/journal.pbio.3002743⟩ Article dans une revue hal-04474786v2
Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options Mikael Feracci,Sergio Hernandez,Laura Garlatti,Clemence Mondielli,Renaud Vincentelliet al. International Union of Crystallography journal, 2024, 11 (3), pp.374-383. ⟨10.1107/S205225252400304X⟩ Article dans une revue hal-04746756v1
Macro1 domain residue F156: A hallmark of SARS-CoV-2 de-MARylation specificity Oney Ortega Granda,Karine Alvarez,Maria J Mate-Perez,Bruno Canard,François Ferronet al. Virology, 2023, 587, pp.109845. ⟨10.1016/j.virol.2023.109845⟩ Article dans une revue hal-04199059v1
Viral Instant Mutation Viewer (VIMVer) : a tool to speed up the identification and analysis of new SARS-CoV2 emerging variant and beyond Vincent Wilde,Bruno Canard,François Ferron Viruses, 2023, 15 (8), pp.1628. ⟨10.3390/v15081628⟩ Article dans une revue hal-04149011v1
AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5 Mikael Feracci,Cécilia Eydoux,Véronique Fattorini,Lea Lo Bello,Pierre Gauffreet al. Antiviral Research, 2023, 212, pp.105574. ⟨10.1016/j.antiviral.2023.105574⟩ Article dans une revue hal-04159074v1
Biochemistry of the Respiratory Syncytial Virus L Protein Embedding RNA Polymerase and Capping Activities Priscila Sutto-Ortiz,Jean-François Eléouët,François Ferron,Etienne Decroly Viruses, 2023, 15 (2), pp.341. ⟨10.3390/v15020341⟩ Article dans une revue hal-03981809v1
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex Daniel L Hurdiss,Priscila El Kazzi,Lisa Bauer,Nicolas Papageorgiou,Francois Ferronet al. Science Advances , 2022, 8 (1), ⟨10.1126/sciadv.abj7615⟩ Article dans une revue hal-03572836v1
Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay Sergio Hernández,Mikael Feracci,Carolina Trajano de Jesus,Priscila El Kazzi,Rafik Kaciet al. Antiviral Research, 2022, 204, pp.105364. ⟨10.1016/j.antiviral.2022.105364⟩ Article dans une revue hal-03860671v1
A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome Ashleigh Shannon,Bhawna Sama,Pierre Gauffre,Théo Guez,Françoise Debartet al. Nucleic Acids Research, 2022, 50 (19), pp.11186-11198. ⟨10.1093/nar/gkac876⟩ Article dans une revue hal-03937366v1
Arenaviridae NP-exonuclease inhibition by bisphosphonate Thi Hong van Nguyen,Elsie Yekwa,Barbara Selisko,Bruno Canard,Karine Alvarezet al. International Union of Crystallography journal, 2022, 9 (4), ⟨10.1107/S2052252522005061⟩ Article dans une revue hal-03663359v1
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase Ashleigh Shannon,Véronique Fattorini,Bhawna Sama,Barbara Selisko,Mikael Feracciet al. Nature Communications, 2022, 13, ⟨10.1038/s41467-022-28113-1⟩ Article dans une revue hal-03572811v1
Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect Priscila El Kazzi,Nadia Rabah,Célia Chamontin,Lina Poulain,François Ferronet al. Nucleic Acids Research, 2022, ⟨10.1093/nar/gkac996⟩ Article dans une revue hal-03860650v1
Observation of arenavirus nucleoprotein heptamer assembly Nicolas Papageorgiou,Afroditi Vaitsopoulou,Awa Diop,Thi Hong van Nguyen,Bruno Canardet al. FEBS Open Bio, 2021, ⟨10.1002/2211-5463.13106⟩ Article dans une revue hal-03143071v1
The enzymes for genome size increase and maintenance of large (+)RNA viruses Francois Ferron,Bhawna Sama,Etienne Decroly,Bruno Canard Trends in Biochemical Sciences, 2021, ⟨10.1016/j.tibs.2021.05.006⟩ Article dans une revue hal-03345450v1
First insights into the structural features of Ebola virus methyltransferase activities Coralie Valle,Baptiste Martin,François Ferron,Véronique Roig-Zamboni,Aline Desmyteret al. Nucleic Acids Research, 2021, 49 (3), pp.1737 - 1748. ⟨10.1093/nar/gkaa1276⟩ Article dans une revue hal-03334409v1
Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication Natacha S Ogando,Priscila El Kazzi,Jessika C Zevenhoven-Dobbe,Brenda W Bontes,Alice Decombeet al. Proceedings of the National Academy of Sciences of the United States of America, 2021, ⟨10.1101/2021.05.17.444407⟩ Article dans une revue hal-03411659v1
Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis Ashleigh Shannon,Barbara Selisko,Nhung-Thi-Tuyet Le,Johanna Huchting,Franck Touretet al. Nature Communications, 2020, 11 (1), pp.4682. ⟨10.1038/s41467-020-18463-z⟩ Article dans une revue inserm-03052188v1
A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalian Tobaniviridae Francois Ferron,Humberto Julio Debat,Ashleigh Shannon,Etienne Decroly,Bruno Canard NAR Genomics and Bioinformatics, 2020, 2 (1), ⟨10.1093/nargab/lqz022⟩ Article dans une revue hal-02890583v1
Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites Ashleigh Shannon,Nhung Thi-Tuyet Le,Barbara Selisko,Cecilia Eydoux,Karine Alvarezet al. Antiviral Research, 2020, 178, pp.104793. ⟨10.1016/j.antiviral.2020.104793⟩ Article dans une revue hal-03052253v1
Brothers in Arms: Structure, Assembly and Function of Arenaviridae Nucleoprotein Nicolas Papageorgiou,Maria Spiliopoulou,Thi-Hong van Nguyen,Afroditi Vaitsopoulou,Elsie Yekwa Labanet al. Viruses, 2020, 12 (7), pp.772. ⟨10.3390/v12070772⟩ Article dans une revue hal-03052241v1
Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain Magali Saez-Ayala,Elsie Laban Yekwa,Clémence Mondielli,Loic Roux,Sergio Hernándezet al. Antiviral Research, 2019, 162, pp.79-89. ⟨10.1016/j.antiviral.2018.12.008⟩ Article dans une revue hal-03076409v1
Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein Thi Hong Van Nguyen,Julie Lichiere,Bruno Canard,Nicolas Papageorgiou,Sarah Attoumaniet al. Acta crystallographica Section D : Structural biology [1993-..], 2019, 75 (1), pp.8-15. ⟨10.1107/S2059798318014948⟩ Article dans une revue inserm-02416977v1
The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity Natacha S Ogando,Francois Ferron,Etienne Decroly,Bruno Canard,Clara C Posthumaet al. Frontiers in Microbiology, 2019, 10, ⟨10.3389/fmicb.2019.01813⟩ Article dans une revue hal-02353805v1
Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases Barbara Selisko,Nicolas Papageorgiou,Francois Ferron,Bruno Canard Viruses, 2018, 10 (2), pp.59. ⟨10.3390/v10020059⟩ Article dans une revue hal-02094550v1
A Vaccine Platform against Arenaviruses Based on a Recombinant Hyperattenuated Mopeia Virus Expressing Heterologous Glycoproteins Xavier Carnec,Mathieu Mateo,Audrey Page,Stéphanie Reynard,Jimmy Hortionet al. Journal of Virology, 2018, 92 (12), pp.e02230-17. ⟨10.1128/JVI.02230-17⟩ Article dans une revue hal-02329298v1
Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands Magali Saez-Ayala,Elsie Yekwa,Mauro Carcelli,Bruno Canard,Karine Alvarezet al. International Union of Crystallography journal, 2018, 5 (1), pp.223 - 235. ⟨10.1107/s2052252518001021⟩ Article dans une revue hal-03078366v1
Crystal structures of Lymphocytic choriomeningitis virus endonuclease domain complexed with diketo-acid ligands Magali Saez-Ayala,Elsie Laban Yekwa,Mauro Carcelli,Bruno Canard,Karine Alvarezet al. International Union of Crystallography journal, 2018, 5 (2), pp.223-235. ⟨10.1107/S2052252518001021⟩ Article dans une revue hal-02094538v1
Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA Francois Ferron,Lorenzo Subissi,Ana Theresa Silveira de Morais,Nhung Thi Tuyet Le,Marion Sevajolet al. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (2), pp.E162-E171. ⟨10.1073/pnas.1718806115⟩ Article dans une revue hal-02094607v1
Toscana virus nucleoprotein oligomer organization observed in solution Amal Baklouti,Adeline Goulet,Julie Lichiere,Bruno Canard,Remi Charrelet al. Acta crystallographica Section D : Structural biology [1993-..], 2017, 73 (8), pp.650 - 659. ⟨10.1107/S2059798317008774⟩ Article dans une revue hal-01802854v1
Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2′-modified nucleotide analogues Supanee Potisopon,Francois Ferron,Véronique Fattorini,Barbara Selisko,Bruno Canard Antiviral Research, 2017, 140, pp.25 - 36. ⟨10.1016/j.antiviral.2016.12.021⟩ Article dans une revue hal-01802946v1
Activity inhibition and crystal polymorphism induced by active-site metal swapping Elsie Yekwa,Joelle Khourieh,Bruno Canard,Nicolas Papageorgiou,Francois Ferron Acta crystallographica Section D : Structural biology [1993-..], 2017, 73 (8), pp.641-649. ⟨10.1107/S205979831700866X⟩ Article dans une revue hal-03078421v1
Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins Francois Ferron,Friedemann Weber,Juan de La Torre,Juan Reguera Virus Research, 2017, 234, pp.118 - 134. ⟨10.1016/j.virusres.2017.01.018⟩ Article dans une revue hal-01802833v1
Structural characterization of the N-terminal part of the MERS-CoV nucleocapsid by X-ray diffraction and small-angle X-ray scattering Nicolas Papageorgiou,Julie Lichiere,Amal Baklouti,Francois Ferron,Marion Sevajolet al. Acta crystallographica Section D : Structural biology [1993-..], 2016, 72 (2), pp.192-202. ⟨10.1107/S2059798315024328⟩ Article dans une revue hal-01439080v1
How disordered is my protein and what is its disorder for? A guide through the “dark side” of the protein universe Philippe Lieutaud,François Ferron,Alexey V Uversky,Lukasz Kurgan,Vladimir N Uverskyet al. Intrinsically Disordered Proteins, 2016, 4 (1), pp.e1259708. ⟨10.1080/21690707.2016.1259708⟩ Article dans une revue hal-03499972v1
Enzymatic synthesis of acyclic nucleoside thiophosphonate diphosphates: Effect of the alpha-phosphorus configuration on HIV-1 RT activity Stephane Priet,Loic Roux,Magali Saez-Ayala,Francois Ferron,Bruno Canardet al. Antiviral Research, 2015, 117, pp.122-131. ⟨10.1016/j.antiviral.2015.03.003⟩ Article dans une revue hal-01439000v1
Crystallization and diffraction analysis of the SARS coronavirus nsp10-nsp16 complex. Claire Debarnot,Isabelle Imbert,Francois Ferron,Laure Gluais,Isabelle Varletet al. Acta crystallographica Section F : Structural biology communications [2014-..], 2011, 67 (Pt 3), pp.404-8. ⟨10.1107/S1744309111002867⟩ Article dans une revue hal-00751530v1
VaZyMolO: a tool to define and classify modularity in viral proteins François Ferron,Corinne Rancurel,Sonia Longhi,Christian Cambillau,Bernard Henrissatet al. Journal of General Virology, 2005, 86 (3), pp.743-749. ⟨10.1099/vir.0.80590-0⟩ Article dans une revue hal-04080540v1
The modeled structure of the RNA dependent RNA polymerase of GBV-C virus suggests a role for motif E in Flaviviridae RNA polymerases. Francois Ferron,Cécile Bussetta,Hélène Dutartre,Bruno Canard BMC Bioinformatics, 2005, 6 (1), pp.255. ⟨10.1186/1471-2105-6-255⟩ Article dans une revue hal-02459250v1
The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world Marie-Pierre Egloff,Francois Ferron,Valérie Campanacci,Sonia Longhi,Corinne Rancurelet al. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (11), pp.3792-3796. ⟨10.1073/pnas.0307877101⟩ Article dans une revue hal-02459257v1
Structural genomics of the SARS coronavirus: cloning, expression, crystallization and preliminary crystallographic study of the Nsp9 protein Valérie Campanacci,Marie-Pierre Egloff,Sonia Longhi,François Ferron,Corinne Rancurelet al. Acta Crystallographica Section D: Biological Crystallography, 2003, 59 (9), pp.1628-1631. ⟨10.1107/S0907444903016779⟩ Article dans une revue hal-04080543v1

Chapitre d'ouvrage (2)

The Phlebovirus Ribonucleoprotein: An Overview François Ferron,Julien Lescar Rift Valley Fever Virus, 2824, Springer US, pp.259-280, 2024, Methods in Molecular Biology, ⟨10.1007/978-1-0716-3926-9_17⟩ Chapitre d'ouvrage hal-04746919v1
Predicting Conformational Disorder Philippe Lieutaud,François Ferron,Sonia Longhi Data Mining Techniques for the Life Sciences, 1415, Springer New York, pp.265-299, 2016, Methods in Molecular Biology, ⟨10.1007/978-1-4939-3572-7_14⟩ Chapitre d'ouvrage hal-03499961v1

Communication dans un congrès (2)

Structural characterisation and inhibition of arenavirus replication complex elements: assembly, function and inhibition of embedded nucleases S. Hernandez,N. Papageorgiou,M. Spiliopoulou,M. Ferracci,L. Garlattiet al. XXVI IUCr Congress Melbourne, Australia, 22-29 August 2023, Aug 2023, MELBOURNE, Australia. pp.C677-C677, ⟨10.1107/S2053273323089404⟩ Communication dans un congrès hal-04748656v1
Cellular activation pathway of bemnifosbuvir (AT-527), a drug candidate against SARS-CoV-2 infections A. Chazot,C. Zimberger,M. Feracci,S. Hernandez,C. Falcouet al. XXVI IUCr Congress Melbourne, Australia, 22-29 August 2023, Aug 2023, MELBOURNE, Australia. pp.C1042-C1042, ⟨10.1107/S2053273323085790⟩ Communication dans un congrès hal-04748663v1

Proceedings/Recueil des communications (1)

A highly specific N7-guanine RNA cap methyltransferase in an unusual locus of large RNA virus genome A. Shannon,B. Sama,P. Gauffre,B. Makem-Tamekem,E. Decrolyet al. Acta Crystallographica Section A : Foundations and Advances [2014-..], 78 (a2), pp.e324-e324, 2022, ⟨10.1107/S2053273322094049⟩ Proceedings/Recueil des communications hal-04252756v1

Pré-publication, Document de travail (5)

Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527 Ashleigh Shannon,Véronique Fattorini,Bhawna Sama,Barbara Selisko,Mikael Feracciet al. 2021 Pré-publication, Document de travail hal-03367971v1
Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication Natacha S Ogando,Priscila El Kazzi,Clara C Posthuma,Volker Thiel,Bruno Canardet al. 2021 Pré-publication, Document de travail hal-03426119v1
A high-throughput fluorescence polarization assay to discover inhibitors of arenavirus and coronavirus exoribonucleases Sergio Hernández,Mikael Feracci,Carolina Trajano de Jesus,Priscila El-Kazzi,Rafik Kaciet al. 2021 Pré-publication, Document de travail hal-03411674v1
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex Daniel L Hurdiss,Priscila El Kazzi,Lisa Bauer,Nicolas Papageorgiou,Francois Ferronet al. 2021 Pré-publication, Document de travail hal-03411664v1
Arenaviridae exoribonuclease presents genomic RNA edition capacity. Elsie Laban Yekwa,Chutima Aphibanthammakit,Xavier Carnec,Caroline Picard,Bruno Canardet al. 2019 Pré-publication, Document de travail hal-02361017v1

Autre publication scientifique (1)

Identification of a Nidovirales Orf1a N7-guanine cap Methyltransferase signature- sequence as a genetic marker of large genome Tobaniviridae Running title: RNA cap N7-guanine Methyltransferase in Tobaniviridae Orf1a Francois Ferron,Humberto Julio Debat,Etienne Decroly,Bruno Canard 2019, ⟨10.1101/639369⟩ Autre publication scientifique hal-02354224v1

HDR (1)

Etudes structurales des assemblages macromoléculaires : Du cytosquelette d'actine aux virus à ARN Francois Ferron Sciences du Vivant [q-bio]. Aix-Marseille Université, 2015 HDR tel-02329070v1

Thèse (1)

Approches bioinformatiques et structurales des replicases virales Francois Ferron Autre [q-bio.OT]. Université de la Méditerranée - Aix-Marseille II, 2005. Français. ⟨NNT : ⟩ Thèse tel-00010419v2