François Guérard

Publications

Article dans une revue (39)

Unveiled Impact of 211 At-Labeled Compounds' Ability to Form Halogen Bonds on their In Vivo Stability Samuel D Mador,Thibault Yssartier,Jean-Yves Le Questel,Gilles Montavon,François Guérardet al. ACS Physical Chemistry Au, 2025, ⟨10.1021/acsphyschemau.5c00091⟩ Article dans une revue inserm-05387652v1
Preparation of 211At-Labeled (Hetero)aryl Compounds from Triarylsulfonium and Dibenzothiophenium Salts Clémence Maingueneau,Romain Eychenne,Jean-Francois Gestin,François Guérard Organic Letters, 2025, 27 (26), pp.7149-7152. ⟨10.1021/acs.orglett.5c02074⟩ Article dans une revue inserm-05119546v1
Ortho-functionalization of a 211At-labeled aryl compound provides stabilization of the C-At bond against oxidative dehalogenation Romain Fouinneteau,Clémence Maingueneau,Nicolas Galland,Cécile Perrio,François Guérard Scientific Reports, 2025, 15 (1), pp.16877. ⟨10.1038/s41598-025-01162-4⟩ Article dans une revue inserm-05074551v1
Bambusuril as an effective astatide sequestrator agent by hydrogen bonding Clémence Maingueneau,Julie Patissou,Marine Lafosse,Elise Cartier,Jean-Francois Gestinet al. Chemical Communications, 2025, 61 (66), pp.12361-12364. ⟨10.1039/D5CC02762D⟩ Article dans une revue hal-05149177v1
Preclinical and Clinical Feasibility Studies as the First Step Before Forthcoming Intravesical Instillation of [211At]At-anti-CA-IX Antibody (ATO-101™) Study in Patients with Non-Muscle-Invasive Bladder Cancer Unresponsive to Standard of Care Caroline Rousseau,Pierre Baumgartner,Marie-Françoise Heymann,Manon Taupin,Jean-François Chatalet al. Cancers, 2025, 17 (7), pp.1190. ⟨10.3390/cancers17071190⟩ Article dans une revue inserm-05384257v1
Stable astatine–metal bonds in gold-based carriers for targeted alpha-particle therapy: role of charge-shift bonding Samuel D Mador,Franck Fuster,François Guérard,Julien Pilmé,Nicolas Galland Inorganic Chemistry Frontiers, 2025, 12 (21), pp.6837-6846. ⟨10.1039/D5QI01028D⟩ Article dans une revue hal-05324453v1
Recent advances in understanding and improving the stability of 211At-radiopharmaceuticals Romain Fouinneteau,Nicolas Galland,Cécile Perrio,François Guérard Nuclear Medicine and Biology, 2025, 150-151, pp.109573. ⟨10.1016/j.nucmedbio.2025.109573⟩ Article dans une revue inserm-05322183v1
Formation Of Gold-Astatine Bonds in N-Heterocyclic Carbene Complexes Mathilde Ligeour,Sébastien G Guillet,Clémence Maingueneau,Mikaël Croyal,Aurélien Planchatet al. Chemistry - A European Journal, 2025, Online ahead of print. ⟨10.1002/chem.202500826⟩ Article dans une revue inserm-05063252v1
In vivo stability of 211At-radiopharmaceuticals: on the impact of halogen bond formation Thibault Yssartier,Lu Liu,Sylvain Pardoue,Jean-Yves Le Questel,François Guérardet al. RSC Medicinal Chemistry, 2024, 15, pp.223-233. ⟨10.1039/d3md00579h⟩ Article dans une revue hal-04304417v1
Sydnone-based prosthetic groups for radioiodination Ludovic Le Saux,Ferid Haddad,Jean-François Gestin,Romain Eychenne,François Guérard Bioorganic and Medicinal Chemistry, 2024, 113, pp.117904. ⟨10.1016/j.bmc.2024.117904⟩ Article dans une revue inserm-04688208v2
Brain intratumoural astatine-211 radiotherapy targeting syndecan-1 leads to durable glioblastoma remission and immune memory in female mice Loris Roncali,Séverine Marionneau-Lambot,Charlotte Roy,Romain Eychenne,Sébastien Gouardet al. EBioMedicine, 2024, 105, ⟨10.1016/j.ebiom.2024.105202⟩ Article dans une revue hal-04991449v2
Astatine-211 radiolabelling chemistry: from basics to advanced biological applications Maarten Vanermen,Mathilde Ligeour,Maria-Cristina Oliveira,Jean-François Gestin,Filipe Elvaset al. European Association of Nuclear Medicine, issuing body - EJNMMI radiopharmacy and chemistry, 2024, 9 (1), pp.69. ⟨10.1186/s41181-024-00298-4⟩ Article dans une revue inserm-04735156v1
211At and 125I‐labeling of (hetero)aryliodonium ylides: astatine wins again Clémence Maingueneau,Marion Berdal,Romain Eychenne,Jöelle Gaschet,Michel Chérelet al. Chemistry - A European Journal, 2022, 28 (11), ⟨10.1002/chem.202104169⟩ Article dans une revue hal-03507646v1
How radiolysis impacts astatine speciation? Mohammad Ghalei,Parastoo Mahdi Khoshouei,Johan Vandenborre,François Guérard,Guillaume Blainet al. Radiation Physics and Chemistry, 2022, 198, pp.110224. ⟨10.1016/j.radphyschem.2022.110224⟩ Article dans une revue inserm-03668885v1
Advances in the chemistry of astatine and implications for the development of radiopharmaceuticals François Guérard,Clémence Maingueneau,Lu Liu,Romain Eychenne,Jean-François Gestinet al. Accounts of Chemical Research, 2021, 54 (16), pp.3264. ⟨10.1021/acs.accounts.1c00327⟩ Article dans une revue inserm-03290202v1
Overview of the Most Promising Radionuclides for Targeted Alpha Therapy: The “Hopeful Eight” Romain Eychenne,Michel Chérel,Férid Haddad,François Guérard,Jean-François Gestin Pharmaceutics, 2021, 13 (6), pp.906. ⟨10.3390/pharmaceutics13060906⟩ Article dans une revue inserm-03292397v1
Investigation on the reactivity of nucleophilic radiohalogens with arylboronic acids in water: access to an efficient single-step method for the radioiodination and astatination of antibodies Marion Berdal,Sébastien Gouard,Romain Eychenne,Séverine Marionneau-Lambot,Mikaël Croyalet al. Chemical Science, 2021, 12 (4), pp.1458-1468. ⟨10.1039/D0SC05191H⟩ Article dans une revue inserm-03024891v1
Targeted-Alpha-Therapy Combining Astatine-211 and anti-CD138 Antibody in a Preclinical Syngeneic Mouse Model of Multiple Myeloma Minimal Residual Disease Sébastien Gouard,Catherine Saï-Maurel,Séverine Marionneau-Lambot,Delphine Dansette,Clément Baillyet al. Cancers, 2020, 12 (9), pp.2721. ⟨10.3390/cancers12092721⟩ Article dans une revue inserm-03006927v1
Reply to the 'Comment on &quot;Investigation of Zr(IV) and 89 Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging&quot;' by A. Bianchi and M. Savastano, Chem. Commun., 2020, 56, D0CC01189D François Guérard,Yong-Sok Lee,Raphaël Tripier,Lawrence Szajek,Jeffrey Deschampset al. Chemical Communications, 2020, Online ahead of print. ⟨10.1039/d0cc03594g⟩ Article dans une revue inserm-02947405v1
Cell Tracking in Cancer Immunotherapy Justine Perrin,Marisa Capitao,Marie Mougin-Degraef,François Guérard,Alain Faivre-Chauvetet al. Frontiers in Medicine, 2020, 7, pp.34. ⟨10.3389/fmed.2020.00034⟩ Article dans une revue inserm-02512946v1
Prosthetic groups for radioiodination and astatination of peptides and proteins: a comparative study of five potential bioorthogonal labeling strategies Laurent Navarro,Marion Berdal,Michel Chérel,Frédéric Pecorari,Jean-François Gestinet al. Bioorganic and Medicinal Chemistry, In press, pp.167-174. ⟨10.1016/j.bmc.2018.11.034⟩ Article dans une revue inserm-01939636v1
Direct nucleophilic radioiodination and astatination of antibodies via pre-conjugated arylboronic acids Marion Berdal,Laurent Navarro,Cyrille Alliot,Michel Chérel,Alain Faivre-Chauvetet al. Journal of Labelled Compounds and Radiopharmaceuticals, 2019 Article dans une revue inserm-02340736v1
What is the Best Radionuclide for Immuno-PET of Multiple Myeloma? A Comparison Study Between 89Zr- and 64Cu-Labeled Anti-CD138 in a Preclinical Syngeneic Model Clément Bailly,Sébastien Gouard,François Guérard,Benjamin Chalopin,Thomas Carlieret al. International Journal of Molecular Sciences, 2019, 20 (10), pp.2564. ⟨10.3390/ijms20102564⟩ Article dans une revue hal-02141555v1
Propriétés et applications de l'astate en médecine nucléaire François Guérard Les Techniques de l'Ingenieur, 2018 Article dans une revue inserm-01960094v1
Efficacy of Astatine-211 radioimmunotherapy of Multiple Myeloma using an anti-mCD138 monoclonal antibody in a syngeneic murine model Sébastien Gouard,Benjamin Chalopin,Catherine Saï-Maurel,François Guérard,Laurent Navarroet al. European Journal of Nuclear Medicine and Molecular Imaging, 2018, 45 (1), pp.S166-S167 Article dans une revue inserm-02341491v1
L’astate-211 pour la radiothérapie vectorisée des cancers François Guérard L'Actualité Chimique, 2017, 52, pp.143-144 Article dans une revue inserm-01628339v1
Investigation of the complexation of nat Zr(IV) and 89 Zr(IV) by hydroxypyridinones for the development of chelators for PET imaging applications François Guérard,Maryline Beyler,Y.-S Lee,Raphaël Tripier,Jean-François Gestinet al. Dalton Transactions, 2017, 46, pp.4749-4758. ⟨10.1039/c6dt04625h⟩ Article dans une revue inserm-01496515v1
Radioimmunoconjugates for treating cancer: recent advances and current opportunities Mickael Bourgeois,Clément Bailly,Mathieu Frindel,François Guérard,Michel Chérelet al. Expert Opinion on Biological Therapy, 2017, 17 (7), pp.813 - 819. ⟨10.1080/14712598.2017.1322577⟩ Article dans une revue inserm-01635514v1
PET Imaging for Initial Staging and Therapy Assessment in Multiple Myeloma Patients Clément Bailly,Rodolphe Leforestier,Bastien Jamet,Thomas Carlier,Mickael Bourgeoiset al. International Journal of Molecular Sciences, 2017, 18 (2), pii: E445. ⟨10.3390/ijms18020445⟩ Article dans une revue inserm-01500327v1
Bifunctional aryliodonium salts for highly efficient radioiodination and astatination of antibodies François Guérard,Laurent Navarro,Y.-S. Lee,Aurélia Roumesy,Cyrille Alliotet al. Bioorganic and Medicinal Chemistry, 2017, Epub ahead of print. ⟨10.1016/j.bmc.2017.09.022⟩ Article dans une revue inserm-01592684v1
Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts François Guérard,Yong-Sok Lee,Kwamena Baidoo,Jean-François Gestin,Martin W Brechbiel Chemistry - A European Journal, 2016, 22 (35), pp.12332-9. ⟨10.1002/chem.201600922⟩ Article dans une revue inserm-01387016v1
Immuno-PET for Clinical Theranostic Approaches Clément Bailly,Pierre-François Cléry,Alain Faivre-Chauvet,Mickael Bourgeois,François Guérardet al. International Journal of Molecular Sciences, 2016, 18 (1), Epub ahead of print. ⟨10.3390/ijms18010057⟩ Article dans une revue inserm-01636873v1
Cover Picture: Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts (Chem. Eur. J. 35/2016) François Guérard,Yong‐sok Lee,Kwamena Baidoo,Jean‐françois Gestin,Martin Brechbiel Chemistry - A European Journal, 2016, 22 (35), pp.12201-12201. ⟨10.1002/chem.201602704⟩ Article dans une revue hal-04964129v1
Radioimmunotherapy for Treatment of Acute Leukemia Caroline Bodet-Milin,Françoise Kraeber-Bodéré,Thomas Eugène,François Guérard,Joëlle Gaschetet al. Seminars in Nuclear Medicine, 2016, 46, pp.135-146. ⟨10.1053/j.semnuclmed.2015.10.007⟩ Article dans une revue inserm-01280232v1
Which radionuclide, carrier molecule and clinical indication for alpha-immunotherapy? François Guérard,Jacques Barbet,Ferid Haddad,Michel Cherel,Francoise Kraeber-Bodereet al. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutic, 2015 Article dans une revue hal-02415080v1
Tumor Immunotargeting Using Innovative Radionuclides Françoise Kraeber-Bodéré,Caroline Rousseau,Caroline Bodet-Milin,Cédric Mathieu,François Guérardet al. International Journal of Molecular Sciences, 2015, 16 (2), pp.3932 - 3954. ⟨10.3390/ijms16023932⟩ Article dans une revue inserm-01818715v1
Investigation of Zr( iv ) and 89 Zr( iv ) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging François Guérard,Yong-Sok Lee,Raphaël Tripier,Lawrence P. Szajek,Jeffrey R. Deschampset al. Chemical Communications, 2013, 49 (10), pp.1002 - 1004. ⟨10.1039/C2CC37549D⟩ Article dans une revue hal-01555852v1
Production of [211 At]-Astatinated Radiopharmaceuticals and Applications in Targeted alpha-Particle Therapy François Guérard,Jean-François Gestin,Martin W Brechbiel Cancer Biotherapy and Radiopharmaceuticals, 2013, 28 (1), pp.1-20. ⟨10.1089/cbr.2012.1292⟩ Article dans une revue inserm-02496646v1
Feasibility of the radioastatination of a monoclonal antibody with astatine-211 purified by wet extraction Mickaël Bourgeois,François Guérard,Cyrille Alliot,Marie Mougin-Degraef,Holisoa Rajerisonet al. Journal of Labelled Compounds and Radiopharmaceuticals, 2008, 51 (11), pp.379 - 383. ⟨10.1002/jlcr.1543⟩ Article dans une revue istex inserm-03290253v1

Communication dans un congrès (16)

Towards radiolabeling using metallic astatine-211: evaluation of ligands for complexation of At+ Camille Custodio,Samuel Danladi Mador,Pierre Rouanet,Ferid Haddad,Nicolas Gallandet al. 26th International Symposium on Radiopharmaceutical Sciences, May 2025, Broadbeach, Australia Communication dans un congrès hal-05362175v1
Evaluation of ligands for rational design of chelators for metallic astatine-211 Camille Custodio,Samuel Danladi Mador,Pierre Rouanet,Ferid Haddad,Nicolas Gallandet al. 7èmes Journées Scientifiques 2025 du GDR AMI, Jun 2025, Nantes, France Communication dans un congrès hal-05362647v1
211At-metal N-Heterocyclic Carbene complexes: a promising alternative for targeted alpha therapy Sébastien G Guillet,Samuel Danladi Mador,Mathilde Ligeour,Nicolas Galland,François Guérard 26th International Symposium on Radiopharmaceutical Sciences, May 2025, Broadbeach, Australia Communication dans un congrès hal-05362219v1
Design of Astatine(I) chelates for applications in targeted alpha therapy Pierre Rouanet,Samuel Danladi Mador,Camille Custodio,François Guérard,Nicolas Galland JTMS 2025 : Journées "Théorie, Modélisation et Simulation", Nov 2025, Bordeaux, France Communication dans un congrès hal-05361499v1
Impact of halogen bonding on stability of astatine-211 labelled compounds Samuel Danladi Mador,Thibault Yssartier,François Guérard,Jy. Le Questel,Gilles Montavonet al. 2èmes Journées scientifiques du GDR Sigma-Hole, Jun 2025, Orsay, France Communication dans un congrès hal-05361583v1
Preparation and evaluation of stabilized 211At-labelled aryl compounds Romain Fouinneteau,Thibault Yssartier,Nicolas Galland,Cécile Perrio,François Guérard ESRR’24 : 21st European Symposium on Radiopharmacy & Radiopharmaceuticals, Apr 2024, Coimbra, Portugal Communication dans un congrès hal-05367201v1
Design and evaluation of 211 At metal N-Heterocyclic Carbenes for targeted alpha therapy Sébastien Guillet,Samuel Danladi Mador,Mathilde Ligeour,Nicolas Galland,François Guérard 12th China-Japan-Korea Symposium on Radiopharmaceutical Sciences (CJKSRS 2024), Sep 2024, Kanazawa, Japan Communication dans un congrès hal-05367227v1
Stable Astatine-211 labeling assisted by charge-shift bonding Samuel Danladi Mador,Mathilde Ligeour,François Guérard,Julien Pilmé,Nicolas Galland Rencontres ThéMoSiA-RCTF 2024, Jun 2024, Rouen, France Communication dans un congrès hal-05367197v1
Molecular modelling towards stable Astatine-211 labelling for targeted alpha therapy Samuel Danladi Mador,Thibault Yssartier,Mathilde Ligeour,François Guérard,Julien Pilméet al. Public event "PRISMAP in Nantes", Sep 2024, Nantes, France Communication dans un congrès hal-05367187v1
O-53 Theoretical and experimental study of astatine-metal bonds: towards new 211At-labelling approaches based on transition metal complexes Mathilde Ligeour,Nicolas Galland,Jean-Francois Gestin,Francois Guérard International Symposium on Radiopharmaceutical Sciences iSRS 2023, May 2023, Honolulu, United States. pp.108449, ⟨10.1016/j.nucmedbio.2023.108449⟩ Communication dans un congrès hal-04688238v1
O-66 - Preparation of 211At-labeled aromatic compounds from thioarylprecursors Clémence Maingueneau,Romain Eychenne,Jean-François Gestin,François Guérard International Symposium of radiopharmaceutical sciences, May 2022, Nantes, France Communication dans un congrès inserm-03842544v1
P-230 - Aryliodonium ylides as efficient precursors for astatine-211 labeling Clémence Maingueneau,Marion Berdal,Romain Eychenne,Joëlle Gaschet,Michel Chérelet al. International symposium of radiopharmaceutical sciences, May 2022, Nantes, France Communication dans un congrès inserm-03842392v1
P-169 - Influence of radiolysis on astatine-211 chemistry Mohammad Ghalei,Parastoo Mahdi Khoshouei,Johan Vandenborre,François Guérard,Guillaume Blainet al. International symposium of radiopharmaceutical sciences, May 2022, Nantes, France Communication dans un congrès inserm-03821660v1
Targeted alpha-therapy with 211At-anti-mCD138 mAb in a syngeneic murine Multiple Myeloma model : can repeated doses or fractionation protocol overpass single dose efficiency? Sébastien Gouard,Séverine Marionneau-Lambot,Joëlle Gaschet,Sébastien Chouin,F. Haddadet al. 33rd Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), European-Association-of-Nuclear-Medicine (EANM), Oct 2020, Virtuel, France. pp.S410-S411, ⟨10.1158/1078-0432.CCR-18-⟩ Communication dans un congrès inserm-03500243v1
Synthesis of precursors for 211At-labelling of anti-PSMA HuJ591 mAb and stability comparison after in vitro cellular internalization Aurélia Roumesy,Sebastien Gouard,Laurent Navarro,Faustine Lelan,Ferid Haddadet al. ISRS 2019, May 2019, PEKIN, China. pp.S69-S70 Communication dans un congrès inserm-02340836v1
Advances in the Radiolabeling of Antibodies with Astatine-211 : Toward Simplified Procedures and Improved Radiochemical Yields François Guérard,Laurent Navarro,Marion Berdal,Ferid Haddad,Michel Chérelet al. TAT 11 INTERNATIONAL SYMPOSIUM, Apr 2019, OTTAWA, Canada. pp.S29 Communication dans un congrès inserm-02340810v1

Poster de conférence (2)

Development of innovative probes for the functional exploration of the anti-apoptotic Mcl-1 Sylvain Routier,Maudou Ndiaye,Laurent Maillet,François Guérard,Karen Pléet al. journée annuelle de l'école doctorale, Jun 2024, Tours, France Poster de conférence hal-04670214v1
Development of innovative probes for the functional exploration of the anti-apoptotic protein Mcl-1 Modou Ndiaye,Laurent Maillet,François Guérard,Karen Plé,Sylvain Routier 18th Belgian Organic Synthesis Symposium (BOSS), Jul 2024, Liege, Belgium Poster de conférence hal-04670206v1

Chapitre d'ouvrage (4)

Radiolabeling Chemistry with Heavy Halogens Iodine and Astatine Romain Eychenne,Cyrille Alliot,Jean-François Gestin,François Guérard Biomedical Sciences, Online ahead of print, 2021 Chapitre d'ouvrage inserm-03332003v1
New Advances in Radioimmunotherapy for the Treatment of Cancers Clément Bailly,Caroline M Bodet-Milin,Caroline Rousseau,François Guérard,Thomas Carlieret al. Bench to Bedside Immunotherapy of Cancers, ch 29, Springer, pp.563-585, 2020, Cancer Immunology, 978-3-030-50286-7. ⟨10.1007/978-3-030-50287-4_29⟩ Chapitre d'ouvrage inserm-03016103v1
Radioimmunotherapy of Lymphomas Clément Bailly,Caroline M Bodet-Milin,François Guérard,Nicolas Chouin,Joëlle Gaschetet al. Nuclear Medicine Therapy, 2019, ⟨10.1007/978-3-030-17494-1_8⟩ Chapitre d'ouvrage inserm-02309716v1
Prospects for Enhancing Efficacy of Radioimmunotherapy Clément Bailly,Caroline Bodet-Milin,François Guérard,Caroline Rousseau,Michel Chérelet al. Resistance to Ibritumomab in Lymphoma, pp.139-153, 2018, ⟨10.1007/978-3-319-78238-6_10⟩ Chapitre d'ouvrage inserm-02315459v1

Brevet (3)

Method for Radioiodination or Radioastatination of a biomolecule Marion Berdal,François Guérard,Jean-François Gestin,Alain Faivre-Chauvet France, Patent n° : WO 2020/221744 A1. 2020 Brevet inserm-03013584v1
Method for Radioioidination OR Radioastatination of a Biomolecule Marion Berdal,Alain Faivre-Chauvet,Jean-François Gestin,François Guérard France, Patent n° : 19305563.9 - 1 109. 2019 Brevet inserm-02547459v1
Method for synthesizing iodo- or astatoarenes using Diaryliodonium Salts François Guérard,Jean-François Gestin,Martin W. Brechbiel,Yong-Sok Lee France, Patent n° : WO 2017/089492 A1. 2017 Brevet inserm-02545737v1