François Hallé

Publications

Article dans une revue (15)

Design, synthesis, and structure–activity relationship studies of 6 H -benzo[ b ]indeno[1,2- d ]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors Abdelfattah Faouzi,Alexandre Arnaud,François Hallé,Jean Roussel,Mandy Aymardet al. RSC Medicinal Chemistry, 2025, 16 (1), pp.179-199. ⟨10.1039/D4MD00537F⟩ Article dans une revue hal-05316119v1
Design, synthesis, and structure–activity relationship studies of 6 H -benzo[ b ]indeno[1,2- d ]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors Abdelfattah Faouzi,Alexandre Arnaud,François Hallé,Jean Roussel,Mandy Aymardet al. RSC Medicinal Chemistry, 2025, 16 (1), pp.179-199. ⟨10.1039/d4md00537f⟩ Article dans une revue hal-04961871v1
A Journey through Hemetsberger–Knittel , Leimgruber–Batcho and Bartoli Reactions: Access to Several Hydroxy 5‐ and 6‐Azaindoles Sylvie Radix,François Hallé,Zahia Mahiout,Amélie Teissonnière,Grégoire Bouchezet al. Helvetica Chimica Acta, 2022, 105 (3), pp.370-375. ⟨10.1002/hlca.202100211⟩ Article dans une revue hal-04933425v1
A Journey through &lt;i&gt;Hemetsberger–Knittel&lt;/i&gt;, &lt;i&gt;Leimgruber–Batcho&lt;/i&gt; and &lt;i&gt;Bartoli&lt;/i&gt; Reactions: Access to Several Hydroxy 5‐ and 6‐Azaindoles Sylvie Radix,François Hallé,Zahia Mahiout,Amélie Teissonnière,Grégoire Bouchezet al. Helvetica Chimica Acta, 2022, 105 (3), pp.e202100211. ⟨10.1002/hlca.202100211⟩ Article dans une revue hal-04950862v1
Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies Amandine Grimm,Imane Lejri,François Hallé,Martine Schmitt,Jürgen Götzet al. Journal of Neuroendocrinology, 2019, ⟨10.1111/jne.12796⟩ Article dans une revue hal-02368671v1
TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis Imane Lejri,Amandine Grimm,François Hallé,Mustapha Abarghaz,Christian Kleinet al. Journal of Alzheimer's Disease, In press, pp.1-14. ⟨10.3233/JAD-190127⟩ Article dans une revue hal-02368657v1
Crystal structure and identification of a pyrimido[6,1-b][1,3]oxazin-6-one derivative from the reaction of acrolein with 5-(phenoxymethyl)-2-amino-2-oxazoline Jean Guillon,Sandra Rubio,Solène Savrimoutou,François Hallé,Stéphane Moreauet al. Comptes Rendus. Chimie, 2018, 21 (11), pp.987-992. ⟨10.1016/j.crci.2018.09.013⟩ Article dans une revue hal-01922305v1
Human erythrocytes release ATP by a novel pathway involving VDAC oligomerization independent of pannexin-1 Irene Marginedas-Freixa,Cora Lilia Alvarez,Martina Moras,María Florencia Leal Denis,Claude Hattabet al. Scientific Reports, 2018, 8, pp.11384. ⟨10.1038/s41598-018-29885-7⟩ Article dans une revue hal-02368694v1
Discovery of Imidazoquinazolinone Derivatives as TSPO Ligands Modulating Neurosteroidogenesis and Cellular Bioenergetics in Neuroblastoma Cells Expressing Amyloid Precursor Protein François Hallé,Imane Lejri,Mustapha Abarghaz,Amandine Grimm,Christian Kleinet al. ChemistrySelect, 2017, 2 (22), pp.6452-6457. ⟨10.1002/slct.201701565⟩ Article dans une revue hal-02368811v1
The translocator protein ligand XBD173 improves clinical symptoms and neuropathological markers in the SJL/J mouse model of multiple sclerosis I. Marginedas-Freixa,C. Hattab,G. Bouyer,F. Halle,A. Cheneet al. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2017, 1863 (12), pp.3016-3027. ⟨10.1016/j.bbadis.2017.09.007⟩ Article dans une revue hal-02290250v1
Emissive Synthetic Cofactors: Enzymatic Interconversions of tz A Analogues of ATP, NAD + , NADH, NADP + , and NADPH François Hallé,Andrea Fin,Alexander Rovira,Yitzhak Tor Angewandte Chemie International Edition, 2017, 57 (4), pp.1087-1090. ⟨10.1002/anie.201711935⟩ Article dans une revue hal-04934214v1
χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds Olivier van Der Poorten,Robin van den Hauwe,Emilie Eiselt,Cecilia Betti,Karel Guillemynet al. ACS Medicinal Chemistry Letters, 2017, 8 (11), pp.1177-1182. ⟨10.1021/acsmedchemlett.7b00347⟩ Article dans une revue hal-02368778v1
TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood I Marginedas-Freixa,C Hattab,G Bouyer,F Halle,A Cheneet al. Scientific Reports, 2016, 6, ⟨10.1038/srep33516⟩ Article dans une revue hal-05431604v1
TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood I Marginedas-Freixa,C Hattab,G Bouyer,F Halle,A Cheneet al. Scientific Reports, 2016, 6, pp.33516 ⟨10.1038/srep33516⟩ Article dans une revue hal-01369499v1
Synthesis of 3-amino-3,4-dihydro-1H-quinolin-2-ones through regioselective palladium-catalyzed intramolecular cyclization François Hallé,Olivier van Der Poorten,Christelle Doebelin,Marie Niederst,Séverine Schneideret al. Tetrahedron Letters, 2016, 57 (14), pp.1547-1550. ⟨10.1016/j.tetlet.2016.02.094⟩ Article dans une revue istex hal-02290245v1

Thèse (1)

Conception, développement et synthèse de ligands du TSPO dans le but de traiter les maladies neurodégénératives François Hallé Autre. Université de Strasbourg, 2015. Français. ⟨NNT : 2015STRAF054⟩ Thèse tel-01340864v1