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François SICHEL

30
Documents

Presentation

**SICHEL François** Né le 14 novembre 1959 à Paris XIIème Marié, 2 enfants Nationalité française Adresse professionnelle : › ABTE, Bâtiment Recherche, Centre François Baclesse, Av. du Général Harris, 14076 CAEN-Cedex 05 Tel 02 31 45 51 93 francois.sichel@unicaen.fr Professeur de Toxicologie, UFR Santé, Université de Caen-Normandie et CLCC François Baclesse Directeur de l'EA4651 [Aliments Bioprocédés Toxicologie Environnement](http://abte.eu/ "ABTE"). Responsable du parcours de master Développement Clinique du Médicament. Vice président de la [Société Française de Toxicologie Génétique](http://www.sftg.org/fr/index.php "SFTG"). **Cursus universitaire** - **D.E.A.** "Structure et fonctionnement des systèmes biologiques intégrés", Université de Paris‑sud (Orsay), septembre 1987, mention bien. - Diplôme d'état de **Docteur en Pharmacie** : "Intérêt de la chromatographie liquide rapide par échange d'ions lors de l'analyse et de la purification des protéines" (Directeur de thèse Pr. Edith Bar), soutenue le 17 décembre 1987, mention très honorable avec les félicita­tions du jury. - **Doctorat de l'Univer­sité de Caen**, spécialité pharmacie : "Galactosyltransférase et cancer de l'ovaire : analyse clinique et étude d'un modèle expérimental humain" (Directeur de thèse Pr. Jean-Yves Le Talaër) soutenue le 20 juin 1991, mention très honorable avec les félicitations du jury. - Diplôme d'**Habilitation à Diriger des Recherches**, Université de Caen, 19 septembre 1996.

Publications

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6-Polyaminosteroid Squalamine Analogues Display Antibacterial Activity against Resistant Pathogens

Delphine Vergoz , Flore Nilly , Florie Desriac , Magalie Barreau , Antoine Géry
International Journal of Molecular Sciences, 2023, 24 (10), pp.8568. ⟨10.3390/ijms24108568⟩
Journal articles hal-04161494v1
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Differential normal skin transcriptomic response in total body irradiated mice exposed to scattered versus scanned proton beams

Alexandre Leduc , Samia Chaouni , Frédéric Pouzoulet , Ludovic de Marzi , Frédérique Megnin-Chanet
Scientific Reports, 2021, 11 (1), pp.5876. ⟨10.1038/s41598-021-85394-0⟩
Journal articles hal-03169799v1
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Biological Effects of Scattered Versus Scanned Proton Beams on Normal Tissues in Total Body Irradiated Mice: Survival, Genotoxicity, Oxidative Stress and Inflammation

Samia Chaouni , Alexandre Leduc , Frédéric Pouzoulet , Ludovic de Marzi , Frédérique Megnin-Chanet
Antioxidants , 2020, 9 (12), pp.1170. ⟨10.3390/antiox9121170⟩
Journal articles hal-04151956v1
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Comparative study on gene expression profile in rat lung after repeated exposure to diesel and biodiesel exhausts upstream and downstream of a particle filter

Valérie Lecureur , Christelle Monteil , Marie Jaguin , Fabrice Cazier , David Préterre
Environmental Pollution, 2020, 266 (Part 2), pp.115264. ⟨10.1016/j.envpol.2020.115264⟩
Journal articles hal-02930031v1
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Hadrontherapy Interactions in Molecular and Cellular Biology

Juliette Thariat , Samuel Valable , Carine Laurent , Siamak Haghdoost , Elodie A. Pérès
International Journal of Molecular Sciences, 2020, 21 (1), pp.133. ⟨10.3390/ijms21010133⟩
Journal articles hal-02429129v1
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Nitrogen Dioxide Inhalation Exposures Induce Cardiac Mitochondrial Reactive Oxygen Species Production, Impair Mitochondrial Function and Promote Coronary Endothelial Dysfunction

Ahmed Karoui , Clément Crochemore , Najah Harouki , Cecile Corbiere , David Preterre
International Journal of Environmental Research and Public Health, 2020, 17 (15), ⟨10.3390/ijerph17155526⟩
Journal articles hal-02928488v1
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Complications cardiaques de la radiothérapie mammaire

Emmanuel Kammerer , Jennifer Le Guévelou , Sophie Jacob , Julien Geffrelot , Serge Danhier
Bulletin du Cancer, 2019, 106 (4), pp.379-388. ⟨10.1016/j.bulcan.2019.01.020⟩
Journal articles hal-02160245v1
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Evaluation of Lung Cell Toxicity of Surfactants for Inhalation Route

F Lindenberg , François Sichel , Mathilde Lechevrel , R Respaud , Guillaume Saint-Lorant
Journal of Toxicology and Risk Assessment, 2019, 5 (1), pp.133. ⟨10.23937/2572-4061.1510022⟩
Journal articles hal-02448735v1
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An integrated functional and transcriptomic analysis reveals that repeated exposure to diesel exhaust induces sustained mitochondrial and cardiac dysfunctions

Ahmed Karoui , Clément Crochemore , Paul Mulder , David Preterre , Fabrice Cazier
Environmental Pollution, 2019, 246, pp.518-526. ⟨10.1016/j.envpol.2018.12.049⟩
Journal articles hal-01978723v1

Répartition du mollusque gastéropode nudibranche Dendrodoris limbata (Cuvier, 1804) le long des côtes métropolitaines françaises : apport de l’outil de sciences participatives BioObs

François Sichel , Jean-Pierre Castillo , Pierre Noel , Alain Mayoux , Laurent Colombet
Naturae, 2018, 5, pp.57-62. ⟨10.5852/naturae2018a5⟩
Journal articles hal-02492238v1

Chemical characterization of fine and ultrafine PM, direct and indirect genotoxicity of PM and their organic extracts on pulmonary cells

Sylvain Billet , Yann Landkocz , Perrine Martin , Anthony Verdin , Frédéric Ledoux
Journal of Environmental Sciences, 2018, 71, pp.168-178. ⟨10.1016/j.jes.2018.04.022⟩
Journal articles hal-02025015v1

Comparative study of diesel and biodiesel exhausts on lung oxidative stress and genotoxicity in rats

Thierry Douki , Cécile Corbière , D. Preterre , Perrine Martin , V. Lecureur
Environmental Pollution, 2018, 235, pp.514-524. ⟨10.1016/j.envpol.2017.12.077⟩
Journal articles hal-01711070v1

Influence of aging in the modulation of epigenetic biomarkers of carcinogenesis after exposure to air pollution

Bertrand Fougère , Yann Landkocz , Capucine Lepers , Perrine Martin , Lucie Armand
Experimental Gerontology, 2018, 110, p.125-132. ⟨10.1016/j.exger.2018.05.018⟩
Journal articles hal-02025021v1
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Production of early and late nuclear DNA damage and extracellular 8- oxodG in normal human skin fibroblasts after carbon ion irradiation compared to X-rays

Virginie Prevost , François Sichel , Ivannah Pottier , Alexandre Leduc , Stéphanie Lagadu
Toxicology in Vitro, 2018, 52, pp.116-121. ⟨10.1016/j.tiv.2018.06.004⟩
Journal articles inserm-02181592v1

Impact of after-treatment devices and biofuels on diesel exhausts genotoxicity in A549 cells exposed at air-liquid interface

Claire Barraud , Cécile Corbière , I. Pottier , E. Estace , K. Blanchard
Toxicology in Vitro, 2017, 45 (Part 3), pp.426-433. ⟨10.1016/j.tiv.2017.04.025⟩
Journal articles hal-02025402v1

Cytotoxicity and genotoxicity effects of arsenic trioxide on SQ20B human laryngeal carcinoma cells

Fatma Trabelsi , Rim Khlifi , Didier Goux , Marilyne Guillamin , Amel Hamza-Chaffai
Experimental and Toxicologic Pathology, 2017, 69 (6), pp.349-358. ⟨10.1016/j.etp.2017.02.003⟩
Journal articles hal-02160250v1

Fine and ultrafine atmospheric particulate matter at a multi-influenced urban site: Physicochemical characterization, mutagenicity and cytotoxicity

Yann Landkocz , Frédéric Ledoux , Véronique André , Fabrice Cazier , Paul Genevray
Environmental Pollution, 2017, 221, pp.130-140. ⟨10.1016/j.envpol.2016.11.054⟩
Journal articles hal-02025255v1

Résultats préliminaires de l’étude Paescart : prédiction de l’apparition d’effets secondaires cutanés tardifs après radiothérapie

D. Lecomte Dumont , D. Stefan , F. Sichel , J.-L. Habrand , Carine Laurent
Cancer/Radiothérapie, 2017, 21 (6-7), pp.712-713. ⟨10.1016/j.canrad.2017.08.077⟩
Journal articles hal-02479011v1

Is hyperthermic intraperitoneal chemotherapy (HIPEC) safe for healthcare workers?

Simon Rodier , Guillaume Saint-Lorant , Jean-Marc Guilloit , Agnès Palix , Fabienne Divanon
Surgical Oncology, 2017, 26 (3), pp.242-251. ⟨10.1016/j.suronc.2017.04.001⟩
Journal articles hal-02025028v1

Genotoxic effects of cadmium in human head and neck cell line SQ20B

Fatma Trabelsi , Rim Khlifi , Didier Goux , Marilyne Guillamin , Amel Hamza-Chaffai
Environmental Science and Pollution Research, 2016, 23 (16), pp.16127-16136. ⟨10.1007/s11356-016-6772-4⟩
Journal articles hal-02025265v1
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Comparative mutagenicity and genotoxicity of particles and aerosols emitted by the combustion of standard vs. rapeseed methyl ester supplemented bio-diesel fuels

V. Andre , Claire Barraud , David Capron , D. Preterre , V. Keravec
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2015, 777, pp.33-42. ⟨10.1016/j.mrgentox.2014.11.007⟩
Journal articles hal-02025276v1

Mutagenicity and clastogenicity of native airborne particulate matter samples collected under industrial, urban or rural influence

C. Lepers , M. Dergham , L. Armand , Sylvain Billet , A. Verdin
Toxicology in Vitro, 2014, 28 (5), pp.866-874. ⟨10.1016/j.tiv.2014.03.011⟩
Journal articles hal-02186761v1

Xenobiotic metabolism induction and bulky DNA adducts generated by particulate matter pollution in BEAS-2B cell line: geographical and seasonal influence

Capucine Lepers , Veronique Andre , Mona Dergham , Sylvain Billet , Anthony Verdin
Journal of Applied Toxicology, 2014, 34 (6), pp.703-713. ⟨10.1002/jat.2931⟩
Journal articles hal-02160269v1

Polycyclic aromatic hydrocarbons within airborne particulate matter (PM 2.5 ) produced DNA bulky stable adducts in a human lung cell coculture model

Imane Abbas , Guillaume Garçon , Françoise Saint-Georges , Veronique Andre , Pierre Gosset
Journal of Applied Toxicology, 2013, 33 (2), pp.109-119. ⟨10.1002/jat.1722⟩
Journal articles hal-02186813v1

Benzo[a]pyrene, Aflatoxine B1 and Acetaldehyde Mutational Patterns in TP53 Gene Using a Functional Assay: Relevance to Human Cancer Aetiology

Vincent Paget , Mathilde Lechevrel , Veronique Andre , Jérémie Le Goff , Didier Pottier
PLoS ONE, 2012, 7 (2), pp.e30921. ⟨10.1371/journal.pone.0030921⟩
Journal articles hal-02186767v1

Mutagenicity and genotoxicity of PM2.5 issued from an urbano-industrialized area of Dunkerque (France)

Véronique André , Sylvain Billet , D. Pottier , J. Le Goff , I. Pottier
Journal of Applied Toxicology, 2011, 31 (2), pp.131-138. ⟨10.1002/jat.1572⟩
Journal articles hal-02186834v1
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8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker of oxidative damage in oesophageal cancer patients: lack of association with antioxidant vitamins and polymorphism of hOGG1 and GST

Stéphanie Lagadu , Mathilde Lechevrel , François Sichel , Jean Breton , Didier Pottier
Journal of experimental & clinical cancer research, 2010, 29 (1), pp.157. ⟨10.1186/1756-9966-29-157⟩
Journal articles hal-02461268v1

Benzene-induced mutational pattern in the tumour suppressor gene TP53 analysed by use of a functional assay, the functional analysis of separated alleles in yeast, in human lung cells

Sylvain Billet , Vincent Paget , Guillaume Garçon , Natacha Heutte , Veronique Andre
Archives of Toxicology, 2010, 84 (2), pp.99-107. ⟨10.1007/s00204-009-0478-z⟩
Journal articles hal-02186869v1

Detection of extracellular 8-oxo-7,8-dihydro-2′-deoxyguanosine as a biomarker of oxidative damage in X-irradiated fibroblast cultures: optimization of analytical procedure

Stéphanie Lagadu , Ivannah Pottier , François Sichel , Carine Laurent , Jean-Louis Lefaix
Biomarkers, 2010, 15 (8), pp.707-714. ⟨10.3109/1354750X.2010.511269⟩
Journal articles hal-02297398v1

Genotoxic potential of Polycyclic Aromatic Hydrocarbons-coated onto airborne Particulate Matter (PM2.5) in human lung epithelial A549 cells

Sylvain Billet , Imane Abbas , Jérémie Le Goff , Anthony Verdin , Veronique Andre
Cancer Letters, 2008, 270 (1), pp.144-155. ⟨10.1016/j.canlet.2008.04.044⟩
Journal articles hal-02186795v1