François-Xavier LEGRAND

Publications

Article dans une revue (45)

Hybrid GPP–hospital control strategy for semi-solid extrusion 3D printing of ONC201 chewable units in pediatric oncology Stephanie Ramos,Marina Vignes,Philippe-Henri Secretan,François-Xavier Legrand,Maxime Annereauet al. European Journal of Pharmaceutical Sciences, 2026, 216, pp.107326. ⟨10.1016/j.ejps.2025.107326⟩ Article dans une revue hal-05318721v1
Hospital-Compounded Birabresib Capsules for NUT Carcinoma: A Quality- and Risk-Based CMC Strategy Maxime Annereau,François-Xavier Legrand,Maria Virginia Sánchez-Becerra,Stéphanie Ramos,Françoise Duperrayet al. Pharmaceutical Research, 2026, ⟨10.1007/s11095-026-04081-9⟩ Article dans une revue hal-05567574v1
Are hydrophilic deep eutectic solvents a potential vehicle for topical delivery of Amphotericin B against cutaneous leishmaniasis? An investigation of physicochemical properties, tolerability and antileishmanial efficacy Cảnh Hưng Nguyễn,Catherine Cailleau,Natalie Fournier,Luc Augis,Françoise Mercier-Noméet al. International Journal of Pharmaceutics, 2026, 689, pp.126439. ⟨10.1016/j.ijpharm.2025.126439⟩ Article dans une revue hal-05397306v1
Hospital 3D-printed cyclophosphamide printlets for paediatric patients Malissa Boucida,Stéphanie Ramos,François-Xavier Legrand,Véronique Minard-Colin,Alexandre Micheletet al. International Journal of Pharmaceutics, 2026, 696, pp.126824. ⟨10.1016/j.ijpharm.2026.126824⟩ Article dans une revue hal-05571619v1
Liposomes loaded with daunorubicin and an emetine prodrug for improved selective cytotoxicity towards acute myeloid leukaemia cells Ingeborg Nerbø Reiten,Francis Giraud,Tuva Torblå Augedal,Jan-Lukas Førde,Pascale Moreauet al. International Journal of Pharmaceutics, 2025, pp.124989. ⟨10.1016/j.ijpharm.2024.124989⟩ Article dans une revue hal-04799525v1
Improvement of the rheological properties and performance of liquid crystal emulsions: influence of oil addition and/or high-frequency ultrasound treatment Amanda Caritá,Hichem Kichou,François-Xavier Legrand,Alexis Verger,Xavier Perseet al. International Journal of Pharmaceutics, 2025, 682, pp.125934. ⟨10.1016/j.ijpharm.2025.125934⟩ Article dans une revue hal-05146411v1
Clinical implementation of a paediatric 3D-printed combination of Sulfamethoxazole and Trimethoprim Maxime Stoops,Bernard Do,Stéphanie Ramos,Bing Xun Tan,Nicholas Yong Sheng Chuaet al. International Journal of Pharmaceutics, 2025, 676, pp.125581. ⟨10.1016/j.ijpharm.2025.125581⟩ Article dans une revue hal-05038883v1
Long-Circulating Liposomes Codelivering Amphotericin B and Retinoic Acid for Cutaneous Leishmaniasis Treatment Thais Santos,Eduardo Lages,Tiago Ricotta,Leandro de Oliveira,Guilherme Ramoset al. ACS Omega, 2025, 10 (41), pp.48514-48530. ⟨10.1021/acsomega.5c06156⟩ Article dans une revue hal-05302818v1
Insights into skin permeation enhancement using neoteric solvents: An ATR-FTIR study on human stratum corneum Luc Augis,Sana Tfaili,François-Xavier Legrand,Ali Tfayli Journal of Molecular Liquids, 2025, 437A, pp.128234. ⟨10.1016/j.molliq.2025.128234⟩ Article dans une revue hal-05193601v1
Porous ionic liquids based on biocompatible CD-MOFs Cintia M Corrêa,Jocasta Avila,Tracy El Achkar,Pauline André,Shi-Minh Looet al. Chemical Communications, 2025, 61 (31), pp.5818-5821. ⟨10.1039/D5CC00489F⟩ Article dans une revue hal-05000112v1
Cocrystallization of Caffeine and Gallic Acid in Water and Methanol: Solid-State Landscape Using Ternary Diagrams Dania Mellah-Hammouni,Yohann Cartigny,François-Xavier Legrand,Nicolas Guiblin,Bertrand Fournieret al. Crystal Growth & Design, 2025, 25 (13), pp.4705-4712. ⟨10.1021/acs.cgd.5c00195⟩ Article dans une revue hal-05112047v1
Repurposing chlorpromazine for anti-leukaemic therapy with the drug-in-cyclodextrin-in-liposome nanocarrier platform Edvin Tang Gundersen,Zhiqiang Wang,Jan-Lukas Førde,Eric Larquet,Reidun Æsøyet al. Carbohydrate Polymers, 2025, 358, pp.123478. ⟨10.1016/j.carbpol.2025.123478⟩ Article dans une revue hal-04981168v1
Effects of Hydrophilic Natural Deep Eutectic Solvents on the Rheological, Textural, and Sensory Properties of Carboxymethylcellulose-Based Cosmetic Hydrogels A Verger,Hichem Kichou,Nicolas Huang,Xavier Perse,I.-M. Ardezaet al. ACS Sustainable Chemistry & Engineering, 2024, 12 (18), pp.7187-7199. ⟨10.1021/acssuschemeng.4c01866⟩ Article dans une revue hal-04570176v1
Development of a pediatric oral solution of ONC201 using nicotinamide to enhance solubility and stability Maxime Annereau,Philippe-Henri Secretan,Marina Vignes,Stéphanie Ramos,Jacques Grillet al. International Journal of Pharmaceutics, 2024, 667 (Part B), pp.124965. ⟨10.1016/j.ijpharm.2024.124965⟩ Article dans une revue hal-04878417v1
A simple access to hexahydropyrimidine from 1,3-diamine: synthesis and solid-state characterization Abdelkhalek Zerrouki,Béatrice Nicolaï,Mustapha Taleb,François-Xavier Legrand,Nicolas Guiblinet al. Structural Chemistry, 2024, 35, pp.813-823. ⟨10.1007/s11224-023-02234-9⟩ Article dans une revue hal-04234932v1
Low melting mixtures: Neoteric green solvents for flavor formulation Miriana Kfoury,François-Xavier Legrand,Steven Ruellan,Sophie Fourmentin Journal of Molecular Liquids, 2024, 394, pp.123696. ⟨10.1016/j.molliq.2023.123696⟩ Article dans une revue hal-04316872v1
Development of nanoparticles based on amphiphilic cyclodextrins for the delivery of active substances Luc Augis,Ingeborg Nerbø Reiten,Jan-Lukas Førde,Juan Casas-Solvas,Christina Sizunet al. International Journal of Pharmaceutics, 2024, 651, pp.123723. ⟨10.1016/j.ijpharm.2023.123723⟩ Article dans une revue hal-04366812v1
Hydrophobic binary mixtures containing amphotericin B as lipophilic solutions for the treatment of cutaneous leishmaniasis Luc Augis,Canh Hung Nguyen,Cécile Ciseran,András Wacha,Françoise Mercier-Noméet al. International Journal of Pharmaceutics, 2024, 662, pp.124486. ⟨10.1016/j.ijpharm.2024.124486⟩ Article dans une revue hal-04660063v1
Fragmentation of DMPC Membranes by a Wedge-Shaped Amphiphilic Cyclodextrin into Bicellar-like Aggregates Michel Roux,François-Xavier Legrand,Abed Bil,Véronique Bonnet,Florence Djedaini-Pilard Journal of Physical Chemistry B, 2023, 127 (11), pp.2475-2487. ⟨10.1021/acs.jpcb.2c07331⟩ Article dans une revue hal-04032341v1
Human dendritic cell maturation induced by amorphous silica nanoparticles is Syk-dependent and triggered by lipid raft aggregation Éléonore Guillet,Emilie Brun,Céline Ferard,Kévin Hardonnière,Myriam Nabhanet al. Particle and Fibre Toxicology, 2023, 20 (1), pp.12. ⟨10.1186/s12989-023-00527-9⟩ Article dans une revue hal-04270376v1
Molecular Mechanisms Involved in the Chemical Instability of ONC201 and Methods to Counter Its Degradation in Solution Maxime Annereau,Marina Vignes,Lucas Denis,André Rieutord,François-Xavier Legrandet al. Pharmaceutics, 2023, 15 (10), pp.2371. ⟨10.3390/pharmaceutics15102371⟩ Article dans une revue hal-04270374v1
Huge solubility increase of poorly water-soluble pharmaceuticals by sulfobutylether-β-cyclodextrin complexation in a low-melting mixture Justine Petitprez,François-Xavier Legrand,Catherine Tams,J. Pipkin,Vince Antleet al. Environmental Chemistry Letters, 2022, 20 (3), pp.1561-1568. ⟨10.1007/s10311-022-01415-y⟩ Article dans une revue hal-04242262v1
New Cocrystallization Method: Non-photochemical Laser-Induced Nucleation of a Cocrystal of Caffeine–Gallic Acid in Water Dania Mellah,Béatrice Nicolaï,Bertrand Fournier,Nada Bošnjaković-Pavlović,Francois-Xavier Legrandet al. Crystal Growth & Design, 2022, 22 (10), pp.5982-5995. ⟨10.1021/acs.cgd.2c00624⟩ Article dans une revue hal-03788064v1
Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application Alban Guesdon Vennerie,P Couvreur,Fatoumia Ali,Frederic Pouzoulet,Christophe Roulinet al. Nature Communications, 2022, 13, pp.4102. ⟨10.1038/s41467-022-30917-0⟩ Article dans une revue hal-03737235v1
Synthetic Amorphous Silica Nanoparticles Promote Human Dendritic Cell Maturation and CD4+ T-Lymphocyte Activation Alexia Feray,Éléonore Guillet,Natacha Szely,Marie Hullo,François-Xavier Legrandet al. Toxicological Sciences, 2022, 185 (1), pp.105-117. ⟨10.1093/toxsci/kfab120⟩ Article dans une revue hal-03604691v1
Discriminative and quantitative analysis of norepinephrine and epinephrine by Surface Enhanced Raman Spectroscopy with gold nanoparticle suspensions Antoine Dowek,Marion Berge,Patrice Prognon,François-Xavier Legrand,Eric Larquetet al. Analytical and Bioanalytical Chemistry, 2021, 414 (2), pp.1163-1176. ⟨10.1007/s00216-021-03743-4⟩ Article dans une revue hal-04664781v1
Tuning morphology of Pickering emulsions stabilised by biodegradable PLGA nanoparticles: How PLGA characteristics influence emulsion properties Baptiste Robin,Claire Albert,Mohamed Beladjine,François-Xavier Legrand,Sandrine Geigeret al. Journal of Colloid and Interface Science, 2021, 595, pp.202-211. ⟨10.1016/j.jcis.2021.03.061⟩ Article dans une revue hal-03209750v1
Optimization of experimental conditions by surface enhanced Raman Scattering (SERS) spectroscopy with gold nanoparticles suspensions Marion Berge,Antoine Dowek,Patrice Prognon,François-Xavier Legrand,Ali Tfayliet al. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy [1994-..], 2021, 268, pp.120628. ⟨10.1016/j.saa.2021.120628⟩ Article dans une revue hal-04270367v1
New generation of supramolecular mixtures: Characterization and solubilization studies Tracy El Achkar,Leila Moura,Tarek Moufawad,Steven Ruellan,Somenath Pandaet al. International Journal of Pharmaceutics, 2020, 584, pp.119443. ⟨10.1016/j.ijpharm.2020.119443⟩ Article dans une revue hal-03102809v1
How to Address the Adjuvant Effects of Nanoparticles on the Immune System Alexia Feray,Natacha Szely,Eléonore Guillet,Marie Hullo,François-Xavier Legrandet al. Nanomaterials, 2020, 10 (3), pp.425. ⟨10.3390/nano10030425⟩ Article dans une revue hal-04049350v1
A mathematical approach to deal with nanoparticle polydispersity in surface enhanced Raman spectroscopy to quantify antineoplastic agents Antoine Dowek,Laetitia Minh Mai Lê,Tom Rohmer,François-Xavier Legrand,Hynd Remitaet al. Talanta, 2020, 217, pp.121040. ⟨10.1016/j.talanta.2020.121040⟩ Article dans une revue hal-02557279v1
The FcγRIIa–Syk Axis Controls Human Dendritic Cell Activation and T Cell Response Induced by Infliximab Aggregates Myriam Nabhan,François-Xavier Legrand,Victor Le-Minh,Baptiste Robin,Rami Becharaet al. Journal of Immunology, 2020, 205 (9), pp.2351-2361. ⟨10.4049/jimmunol.1901381⟩ Article dans une revue hal-04270355v1
Cyclodextrin Complexation Studies as the First Step for Repurposing of Chlorpromazine Zhiqiang Wang,David Landy,Christina Sizun,Christine Cézard,Audrey Solgadiet al. International Journal of Pharmaceutics, 2020, 584, pp.119391. ⟨10.1016/j.ijpharm.2020.119391⟩ Article dans une revue hal-02885940v1
A mathematical approach to deal with nanoparticle polydispersity in surface enhanced Raman spectroscopy to quantify antineoplastic agents Antoine Dowek,Laetitia Minh Mai Lê,Tom Rohmer,François-Xavier Legrand,Hynd Remitaet al. Talanta, 2020, 217, pp.121040. ⟨10.1016/j.talanta.2020.121040⟩ Article dans une revue hal-04294318v1
A mathematical approach to deal with nanoparticle polydispersity in surface enhanced Raman spectroscopy to quantify antineoplastic agents Antoine Dowek,Laetitia Minh Mai Lê,Tom Rohmer,François-Xavier Legrand,Hynd Remitaet al. Talanta, 2020, 217, pp.121040. ⟨10.1016/j.talanta.2020.121040⟩ Article dans une revue hal-03437402v1
Helically shaped cation receptor: design, synthesis, characterisation and first application to ion transport Hamza Boufroura,Romain Plais,Salomé Poyer,Anne Gaucher,Jérôme Marrotet al. RSC Advances, 2020, 10 (52), pp.31670-31679. ⟨10.1039/d0ra05519k⟩ Article dans une revue hal-02923986v1
Interaction of dequalinium chloride with phosphatidylcholine bilayers: A biophysical study with consequences on the development of lipid-based mitochondrial nanomedicines Félix Sauvage,François-Xavier Legrand,Michel Roux,Ivan Rajkovic,Thomas M. Weisset al. Journal of Colloid and Interface Science, 2019, 537, pp.704--715. ⟨10.1016/j.jcis.2018.11.059⟩ Article dans une revue hal-02183686v1
Evaluation of zeta potential of nanomaterials by electrophoretic light scattering: Fast field reversal versus Slow field reversal modes F. Varenne,J.-B. Coty,J Botton,F.-X. Legrand,H. Hillaireauet al. Talanta, 2019, 205, pp.120062. ⟨10.1016/j.talanta.2019.06.062⟩ Article dans une revue hal-02983998v1
Alumina nanoparticles size and crystalline phase impact on cytotoxic effect on alveolar epithelial cells after simple or HCl combined exposures Alexandra Bourgois,David Crouzier,François-Xavier Legrand,Florent Raffin,Alexandre Boyardet al. Toxicology in Vitro, 2019, 59, pp.135-149. ⟨10.1016/j.tiv.2019.04.016⟩ Article dans une revue hal-04270322v1
New nanoparticles obtained by co-assembly of amphiphilic cyclodextrins and nonlamellar single-chain lipids: Preparation and characterization Cảnh Hưng Nguyễn,Jean-Luc Putaux,Gianluca Santoni,Sana Tfaili,Sophie Fourmentinet al. International Journal of Pharmaceutics, 2017, 531 (2), pp.444-456. ⟨10.1016/j.ijpharm.2017.07.007⟩ Article dans une revue hal-02106211v1
Self-Assembly of Amphiphilic Biotransesterified β-Cyclodextrins: Supramolecular Structure of Nanoparticles and Surface Properties Jean-Luc Putaux,Christine Lancelon-Pin,François-Xavier Legrand,Marion Pastrello,Luc Choisnardet al. Langmuir, 2017, 33 (32), pp.7917-7928. ⟨10.1021/acs.langmuir.7b01136⟩ Article dans une revue hal-02106206v1
Size of monodispersed nanomaterials evaluated by dynamic light scattering: Protocol validated for measurements of 60 and 203nm diameter nanomaterials is now extended to 100 and 400nm. F Varenne,J Botton,C Merlet,H Hillaireau,Fx Legrandet al. International Journal of Pharmaceutics, 2016, ⟨10.1016/j.ijpharm.2016.10.016⟩ Article dans une revue hal-01437495v1
Formulation and in vitro efficacy of liposomes containing the Hsp90 inhibitor 6BrCaQ in prostate cancer cells Félix Sauvage,Silvia Franzè,Alexandre Bruneau,Mouad Alami,Stéphanie Deniset al. International Journal of Pharmaceutics, 2016, 499 (1-2), pp.101-109. ⟨10.1016/j.ijpharm.2015.12.053⟩ Article dans une revue istex hal-04354282v1
Single-scan multidimensional NMR analysis of mixtures at sub-millimolar concentrations by using SABRE hyperpolarization Valeria Daniele,François-Xavier Legrand,Patrick Berthault,Jean-Nicolas Dumez,Gaspard Huber ChemPhysChem, 2015, 16, pp.3413-3417. ⟨10.1002/cphc.201500535⟩ Article dans une revue istex hal-01228706v1
Standardization and validation of a protocol of size measurements by dynamic light scattering for monodispersed stable nanomaterial characterization Varenne Fanny,Botton Jérémie,Merlet Claire,Beck-Broichsitter Moritz,Legrand François-Xavieret al. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2015, ⟨10.1016/j.colsurfa.2015.08.043⟩ Article dans une revue hal-01437474v1

Communication dans un congrès (6)

From Solvents to Multifunctional Ingredients: Natural Deep Eutectic Solvents for Sustainable Cosmetic Emulsions Divoux Laura,Alexis Verger,Thiery Emilie,Perse Xavier,Elsa Vrignaudet al. 4th International Meeting on Deep Eutectic Systems, DES Solutio & Nova University, Jun 2025, Lisboa, Portugal Communication dans un congrès hal-05133306v1
From nature to topical medications: current challenges and place of natural eutectic matrices Emilie Munnier,Laura Divoux,Alexis Verger,Elsa Vrignaud,Ecaterina Goreet al. Skin Forum 2025 annual meeting, APV; Skin Forum, Jun 2025, Berlin, Germany Communication dans un congrès hal-05313764v1
Co-crystallization of caffeine and gallic acid in water and methanol: Solid-state landscape using ternary diagrams Dania Mellah,Yohann Cartigny,François-Xavier Legrand,Valérie Dupray,Bertrand Fournieret al. Cristech 2024, Oct 2024, Angers, France Communication dans un congrès hal-04746370v1
NPLIN (Non-Photochemical Laser-Induced nucleation) of caffeine-gallic acid co-crystals in methanol » Dania Mellah,Nada Bosnjakovic-Pavlovic,Nicolas Guiblin,Pascale Gemeiner,Vincent Boemareet al. Cristallisation et Précipitation industrielles Cristal 10, Jun 2022, Lyon, France Communication dans un congrès hal-04064611v1
Supramolecular Eutectics as Solubilizers for Active Pharmaceutical Ingredients Sarah El Masri,Steven Ruellan,François- Xavier Legrand,Sylvie Bouttier,G. Barrattet al. SolvATE2020: Scientific Meeting of the GdR SolvATE, Nov 2020, Webinaire, France Communication dans un congrès hal-04447157v1
Analyse de mélanges de solutés par couplage d'hyperpolarisation par parahydrogène et de séquences ultra-rapides G. Huber,L Guduff,V Daniele,F-X Legrand,Patrick Berthaultet al. GERM, May 2019, Oléron, France Communication dans un congrès cea-02329117v1

Chapitre d'ouvrage (3)

Rayons X et rayonnements émis par les principaux radio-isotopes utilisés in vivo et in vitro Nicolas Huang,François- Xavier Legrand Peyrin E., Willand N., Didier P. (coord.). Chimie analytique - Chimie organique - Biophysique - L'enseignement en fiches, Elsevier Masson, pp.78-98, 2023, Objectif Internat Pharmacie, 9782294779862 Chapitre d'ouvrage hal-04353859v1
Principes et application de la pression osmotique : osmolarité - osmolalité François- Xavier Legrand,Christelle Wisniewski Peyrin E., Willand N., Didier P. (coord.). Chimie analytique - Chimie organique - Biophysique - L'enseignement en fiches, Elsevier Masson, pp.127-131, 2023, Objectif Internat Pharmacie, 9782294779862 Chapitre d'ouvrage hal-04496690v1
Deep Eutectic Solvents for Innovative Pharmaceutical Formulations François-Xavier Legrand,Canh-Hung Nguyen,Luc Augis,Sophie Fourmentin,Gillian Barratt Deep eutectic solvents for innovative pharmaceutical formulations, 56, Springer, pp.41-102, 2021, Environmental Chemistry for a Sustainable World, 978-3-030-53068-6. ⟨10.1007/978-3-030-53069-3_2⟩ Chapitre d'ouvrage hal-03282900v1

Pré-publication, Document de travail (1)

COCHLEATE DRUG DELIVERY SYSTEMS: AN APPROACH TO THEIR CHARACTERIZATION Antonio Lipa-Castro,François-Xavier Legrand,Gillian Barratt 2021 Pré-publication, Document de travail hal-03285762v1