Francoise Debart

Publications

Poster de conférence (1)

COMPARISON OF NON-RADIOACTIVE ASSAYS TO STUDY THE RNA-DEPENDENT RNA-POLYMERASE ACTIVITY OF RESPIRATORY SYNCYTIAL VIRUS IN VITRO Fatemeh Okhravjouybari,Amina Tahir,Didier Chevret,Francoise Debart,Julien Sourimant negative sense virus meeting 2025, Jun 2025, Montpellier, France. 2025 Poster de conférence hal-05155925v1

Pré-publication, Document de travail (2)

Direct interaction between RSV polymerase L and active Rab11a mediates viral ribonucleoprotein transport to assembly sites Claire Giry,Ana Joaquina Jimenez,Julie de Oliveira,Fatemeh Okhravijouybari,Mélissa Bessonneet al. 2025 Pré-publication, Document de travail hal-05371134v1
Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527 Ashleigh Shannon,Véronique Fattorini,Bhawna Sama,Barbara Selisko,Mikael Feracciet al. 2021 Pré-publication, Document de travail hal-03367971v1

Article dans une revue (92)

Synthesis and in vitro inhibitory activity of N-arylsulfonamide adenosine analogues designed to target SARS-CoV-2 nsp14 N7-methyltransferase Marcel Hausdorff,Adrien Delpal,Hugo Machin,Amina Tahir,Jim Zoladeket al. Bioorganic Chemistry, 2025, 166, pp.109104. ⟨10.1016/j.bioorg.2025.109104⟩ Article dans une revue hal-05371098v1
Synthesis of acyclic analogues of adenosine sulfonamides and their activity against RNA cap guanine N 7-methyltransferase of SARS-CoV-2 Rostom Ahmed‐belkacem,Adrien Delpal,Bruno Canard,Jean-Jacques Vasseur,Etienne Decrolyet al. New Journal of Chemistry, 2024, 143, pp.107035. ⟨10.1039/D4NJ02481H⟩ Article dans une revue hal-04741812v1
5′-cap RNA/SAM mimetic conjugates as bisubstrate inhibitors of viral RNA cap 2′-O-methyltransferases Rostom Ahmed‐belkacem,Priscila Sutto-Ortiz,Adrien Delpal,Joris Troussier,Bruno Canardet al. Bioorganic Chemistry, 2024, 143, pp.107035. ⟨10.1016/j.bioorg.2023.107035⟩ Article dans une revue hal-04456996v1
Accelerated, high-quality photolithographic synthesis of RNA microarrays in situ Tadija Kekić,Nemanja Milisavljević,Joris Troussier,Amina Tahir,Françoise Debartet al. Science Advances , 2024, 10 (31), ⟨10.1126/sciadv.ado6762⟩ Article dans une revue hal-04741717v1
N-arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2 Rostom Ahmed‐belkacem,Joris Troussier,Adrien Delpal,Bruno Canard,Jean-Jacques Vasseuret al. RSC Medicinal Chemistry, 2024, ⟨10.1039/d3md00737e⟩ Article dans une revue hal-04426066v1
Serendipitous Synthesis of 5-Hydroxyuridine from 2',3'-O-isopropylidene N4-Acetylcytidine by Hypervalent Iodine(III)-Mediated Reaction Mary Anne Maverick,Mathieu Noël,Jean-Jacques Vasseur,Carine Baraguey,Françoise Debartet al. SYNLETT, 2023, ⟨10.1055/a-2174-2554⟩ Article dans une revue hal-04235363v1
Access to High‐Purity 7m G‐cap RNA in Substantial Quantities by a Convenient All‐Chemical Solid‐Phase Method Mathieu Noël,Theo Guez,Yann Thillier,Jean‐jacques Vasseur,Françoise Debart ChemBioChem, 2023, 24 (2), pp.756-765. ⟨10.1002/cbic.202300544⟩ Article dans une revue hal-04235335v1
AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5 Mikael Feracci,Cécilia Eydoux,Véronique Fattorini,Lea Lo Bello,Pierre Gauffreet al. Antiviral Research, 2023, 212, pp.105574. ⟨10.1016/j.antiviral.2023.105574⟩ Article dans une revue hal-04159074v1
Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases Marcel Hausdorff,Adrien Delpal,Sarah Barelier,Laura Nicollet,Bruno Canardet al. European Journal of Medicinal Chemistry, In press, ⟨10.1016/j.ejmech.2023.115474⟩ Article dans une revue hal-04095336v1
Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect Priscila El Kazzi,Nadia Rabah,Célia Chamontin,Lina Poulain,François Ferronet al. Nucleic Acids Research, 2022, ⟨10.1093/nar/gkac996⟩ Article dans une revue hal-03860650v1
Bisubstrate Strategies to Target Methyltransferases Rostom Ahmed‐belkacem,Françoise Debart,Jean‐jacques Vasseur European Journal of Organic Chemistry, 2022, 2022 (21), pp.e202101481. ⟨10.1002/ejoc.202101481⟩ Article dans une revue hal-03727961v1
Direct Access to Unique C‐5’‐Acyl Modified Nucleosides through Liebeskind–Srogl Cross‐Coupling Reaction Mary Anne Maverick,Marie Gaillard,Jean Jacques Vasseur,Françoise Debart,Michael Smietana European Journal of Organic Chemistry, 2022, 2022 (21), ⟨10.1002/ejoc.202101061⟩ Article dans une revue hal-03737774v1
Inhibiteurs bisubstrats de méthyltransférases virales Rostom Ahmed‐belkacem,J.J. Vasseur,Francoise Debart L'Actualité Chimique, 2022 Article dans une revue hal-03721682v1
Facile access to 4′-( N -acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap N 7-guanine-methyltransferase nsp14 Romain Amador,Adrien Delpal,Bruno Canard,Jean-Jacques Vasseur,Etienne Decrolyet al. Organic & Biomolecular Chemistry, 2022, 20 (38), pp.7582-7586. ⟨10.1039/d2ob01569b⟩ Article dans une revue hal-03801035v1
Importance of RNA length for in vitro encapsidation by the nucleoprotein of human respiratory syncytial virus Lorène Gonnin,Charles-Adrien Richard,Irina Gutsche,Didier Chevret,Joris Troussieret al. Journal of Biological Chemistry, 2022, 298 (9), pp.102337. ⟨10.1016/j.jbc.2022.102337⟩ Article dans une revue hal-03797501v2
A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome Ashleigh Shannon,Bhawna Sama,Pierre Gauffre,Théo Guez,Françoise Debartet al. Nucleic Acids Research, 2022, 50 (19), pp.11186-11198. ⟨10.1093/nar/gkac876⟩ Article dans une revue hal-03937366v1
Potent Inhibition of SARS-CoV-2 nsp14 N 7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues Rostom Ahmed‐belkacem,Marcel Hausdorff,Adrien Delpal,Priscila Sutto-Ortiz,Agathe M G Colmantet al. Journal of Medicinal Chemistry, 2022, 65 (8), pp.6231-6249. ⟨10.1021/acs.jmedchem.2c00120⟩ Article dans une revue hal-03721688v1
The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation Priscila Sutto-Ortiz,Sergey Tcherniuk,Nina Ysebaert,Pravien Abeywickrema,Mathieu Noëlet al. PLoS Pathogens, 2021, 17 (5), pp.1-20. ⟨10.1371/journal.ppat.1009562⟩ Article dans une revue hal-03282037v1
FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell Sébastien Relier,Julie Ripoll,Hélène Guillorit,Amandine Amalric,Cyrinne Achouret al. Nature Communications, 2021, 12 (1), pp.1716. ⟨10.1038/s41467-021-21758-4⟩ Article dans une revue hal-03178788v2
First insights into the structural features of Ebola virus methyltransferase activities Coralie Valle,Baptiste Martin,François Ferron,Véronique Roig-Zamboni,Aline Desmyteret al. Nucleic Acids Research, 2021, 49 (3), pp.1737 - 1748. ⟨10.1093/nar/gkaa1276⟩ Article dans une revue hal-03334409v1
Conjugation of Doxorubicin to siRNA Through Disulfide-based Self-immolative Linkers Florian Gauthier,Jean-Rémi Bertrand,Jean-Jacques Vasseur,Christelle Dupouy,Francoise Debart Molecules, 2020, 25 (11), pp.2714. ⟨10.3390/molecules25112714⟩ Article dans une revue hal-02991729v1
Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase Rostom Ahmed‐belkacem,Priscila Sutto-Ortiz,Mathis Guiraud,Bruno Canard,Jean-Jacques Vasseuret al. European Journal of Medicinal Chemistry, 2020, 201, pp.112557. ⟨10.1016/j.ejmech.2020.112557⟩ Article dans une revue hal-02890580v1
The C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation Coralie Valle,Baptiste Martin,Francoise Debart,Jean-Jacques Vasseur,Isabelle Imbertet al. Journal of Virology, 2020, 94 (12), pp.e00520-20. ⟨10.1128/JVI.00520-20⟩ Article dans une revue hal-02890587v1
Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome Konstantinos Boulias,Diana Toczydłowska-Socha,Ben Hawley,Noa Liberman,Ken Takashimaet al. Molecular Cell, 2019, ⟨10.1016/j.molcel.2019.06.006⟩ Article dans une revue hal-02197217v1
FTO controls reversible m6Am RNA methylation during snRNA biogenesis Jan Mauer,Miriam Sindelar,Vladimir Despic,Théo Guez,Benjamin Hawleyet al. Nature Chemical Biology, 2019, 15 (4), pp.340-347. ⟨10.1038/s41589-019-0231-8⟩ Article dans une revue hal-02197144v1
Conjugation of Small Molecules to RNA Using a Reducible Disulfide Linker Attached at the 2′-OH Position through a Carbamate Function Florian Gauthier,Astrid Malher,Jean-Jacques Vasseur,Christelle Dupouy,Françoise Debart European Journal of Organic Chemistry, 2019, 2019 (33), pp.5636-5645. ⟨10.1002/ejoc.201900740⟩ Article dans une revue hal-02307249v1
Synthesis of Adenine Dinucleosides 2′,5′-Bridged by Sulfur-Containing Linkers as Bisubstrate SAM Analogues for Viral RNA 2′- O -Methyltransferases Rostom Ahmed‐belkacem,Priscila Sutto Ortiz,Etienne Decroly,Jean-Jacques Vasseur,Françoise Debart European Journal of Organic Chemistry, 2019, 2019 (38), ⟨10.1002/ejoc.201901120⟩ Article dans une revue hal-02992283v1
Combining Chemical Synthesis and Enzymatic Methylation to Access Short RNAs with Various 5′ Caps Nils Muthmann,Théo Guez,Jean-Jacques Vasseur,Samie Jaffrey,Françoise Debartet al. ChemBioChem, 2019, ⟨10.1002/cbic.201900037⟩ Article dans une revue hal-02197219v1
Gymnotic delivery and gene silencing activity of reduction-responsive siRNAs bearing lipophilic disulfide-containing modifications at 2′-position Florian Gauthier,Sandra Claveau,Jean-Rémi Bertrand,Jean-Jacques Vasseur,Christelle Dupouyet al. Bioorganic and Medicinal Chemistry, 2018, 26 (16), pp.4635-4643. ⟨10.1016/j.bmc.2018.07.033⟩ Article dans une revue hal-02197153v1
The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure Baptiste Martin,Bruno Coutard,Théo Guez,Guido Paesen,Bruno Canardet al. Nucleic Acids Research, 2018, 46 (15), pp.7902-7912. ⟨10.1093/nar/gky637⟩ Article dans une revue inserm-02416986v1
Ebola virus L protein harbors a new enzymatic activity involved in the internal methylation of RNAs Baptiste Martin,Coralie Valle,Bruno Coutard,Bruno Canard,Françoise Debartet al. Médecine/Sciences, 2018, 34 (11), pp.919-921. ⟨10.1051/medsci/2018230⟩ Article dans une revue hal-02094423v1
Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing Françoise Debart,Christelle Dupouy,Jean-Jacques Vasseur Beilstein Journal of Organic Chemistry, 2018, 14 (26), pp.436-469. ⟨10.3762/bjoc.14.32⟩ Article dans une revue hal-02197155v1
La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region Lucas Philippe,Jean-Jacques Vasseur,Françoise Debart,Carson Thoreen Nucleic Acids Research, 2018, 46 (3), pp.1457-1469. ⟨10.1093/nar/gkx1237⟩ Article dans une revue hal-02197161v1
A 2′,2′-disulfide-bridged dinucleotide conformationally locks RNA hairpins Florian Gauthier,Frédéric Beltran,Annabelle Biscans,Françoise Debart,Christelle Dupouyet al. Organic & Biomolecular Chemistry, 2018, 16 (17), pp.3181-3188. ⟨10.1039/c8ob00328a⟩ Article dans une revue hal-02197157v1
Binding of the Methyl Donor S -Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2′- O -Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10 Wahiba Aouadi,Alexandre Blanjoie,Jean-Jacques Vasseur,Françoise Debart,Bruno Canardet al. Journal of Virology, 2017, 91 (5), pp.1103-1119. ⟨10.1128/JVI.02217-16⟩ Article dans une revue hal-01802788v1
Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay Wahiba Aouadi,C Ecilia Eydoux,Bruno Coutard,Baptiste Martin,Françoise Debartet al. Antiviral Research, 2017, 144, pp.330-339. ⟨10.1016/j.antiviral.2017.06.021⟩ Article dans une revue hal-02349530v1
Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress Ana Tamarkin-Ben-Harush,Jean-Jacques Vasseur,Françoise Debart,Igor Ulitsky,Rivka Dikstein eLife, 2017, 6, ⟨10.7554/eLife.21907⟩ Article dans une revue hal-02197213v1
Reversible methylation of m6Am in the 5′ cap controls mRNA stability Jan Mauer,Xiaobing Luo,Alexandre Blanjoie,Xinfu Jiao,Anya V Grozhiket al. Nature, 2017, 541 (7637), pp.371-375. ⟨10.1038/nature21022⟩ Article dans une revue hal-02197215v1
Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives Bruno Coutard,Karine Barral,Julie Lichiere,Barbara Selisko,Baptiste Martinet al. Journal of Virology, 2017, 91 (5), pp.2202-2218. ⟨10.1128/JVI.02202-16⟩ Article dans une revue hal-01802793v1
Lipophilic 2′- O -Acetal Ester RNAs: Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake, and siRNA Activity after Spontaneous Naked Delivery Annabelle Biscans,Jean-Rémi Bertrand,Josephine Dubois,Jacqueline Rüger,Jean-Jacques Vasseuret al. ChemBioChem, 2016, 17 (21), pp.2054-2062. ⟨10.1002/cbic.201600317⟩ Article dans une revue istex hal-02197248v1
A versatile post-synthetic method on a solid support for the synthesis of RNA containing reduction-responsive modifications Annabelle Biscans,Sonia Rouanet,Jean-Jacques Vasseur,Christelle Dupouy,Françoise Debart Organic & Biomolecular Chemistry, 2016, 14 (29), pp.7010-7017. ⟨10.1039/c6ob01272h⟩ Article dans une revue hal-02197255v1
Synthesis, binding, nuclease resistance and cellular uptake properties of 2′- O -acetalester-modified oligonucleotides containing cationic groups Annabelle Biscans,Sonia Rouanet,Jean-Rémi Bertrand,Jean-Jacques Vasseur,Christelle Dupouyet al. Bioorganic and Medicinal Chemistry Letters, 2015, 23 (17), pp.5360-5368. ⟨10.1016/j.bmc.2015.07.054⟩ Article dans une revue istex hal-03554637v1
mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research Changqing Li,Jaime Guillen,Nadia Rabah,Alexandre Blanjoie,Francoise Debartet al. Journal of Virology, 2015, 89 (16), pp.8292-8303. ⟨10.1128/JVI.00599-15⟩ Article dans une revue hal-01439035v1
X-ray structure and activities of an essential Mononegavirales L-protein domain Guido C. Paesen,Axelle Collet,Corinne Sallamand,Francoise Debart,Jean-Jacques Vasseuret al. Nature Communications, 2015, 6, pp.8749. ⟨10.1038/ncomms9749⟩ Article dans une revue hal-01439027v1
Solid-Phase Synthesis of Oligonucleotide 5′-(α- P -Thio)triphosphates and 5′-(α- P -Thio)(β,γ-methylene)triphosphates Yann Thillier,Corinne Sallamand,Carine Baraguey,Jean-Jacques Vasseur,Françoise Debart European Journal of Organic Chemistry, 2015, 2015 (2), pp.302-308. ⟨10.1002/ejoc.201403381⟩ Article dans une revue istex hal-03554798v1
mRNA maturation in giant viruses: variation on a theme Stéphane Priet,Audrey Lartigue,Françoise Debart,Jean-Michel Claverie,Chantal Abergel Nucleic Acids Research, 2015, 43, pp.3776-3788. ⟨10.1093/nar/gkv224⟩ Article dans une revue hal-01214084v1
Direct Synthesis of Partially Modified 2′-O-Pivaloyloxymethyl RNAs by a Base-Labile Protecting Group Strategy and their Potential for Prodrug-Based Gene-Silencing Applications. Annabelle Biscans,Maxence Bos,Anthony R. Martin,Nicholas Ader,Georg Sczakielet al. ChemBioChem, 2014, 15 (18), pp.2674-2679. ⟨10.1002/cbic.201402382⟩ Article dans une revue istex hal-01101605v1
Ecological catalysis and phytoextraction: symbiosis for future Vincent Escande,Laetitia Garoux,Claire Grison,Yann Thillier,Francoise Debartet al. Applied Catalysis B: Environmental, 2014, 7th International Conference on Environmental Catalysis (ICEC2012), Lyon, France, 146, pp.279-288. ⟨10.1016/j.apcatb.2013.04.011⟩ Article dans une revue hal-03177603v1
The biolabile 2'-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure Carine Lima-Baraguey,Eveline Lescrinier,Thomas Lavergne,Francoise Debart,Piet Herdewijnet al. Organic & Biomolecular Chemistry, 2013, 11, pp.2638-2647. ⟨10.1039/c3ob27005j⟩ Article dans une revue hal-00805121v1
Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening. Karine Barral,Corinne Sallamand,Christiane Petzold,Bruno Coutard,Axelle Colletet al. Antiviral Research, 2013, 99 (3), pp.292-300. ⟨10.1016/j.antiviral.2013.06.001⟩ Article dans une revue istex hal-00874640v1
Metallophyte wastes and polymetallic catalysis: a promising combination in green chemistry. The illustrative synthesis of 59-capped RNA3 Yann Thillier,Guillaume Losfeld,Vincent Escande,Christelle Dupouy,Jean-Jacques Vasseuret al. RSC Advances, 2013, 3 (15), pp.5204-5212. ⟨10.1039/C3RA23115A⟩ Article dans une revue hal-03173870v1
Bacillus subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates Jérémie Piton,Valéry Larue,Yann Thillier,Audrey Dorleans,Olivier Pellegriniet al. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (22), pp.8858-8863. ⟨10.1073/pnas.1221510110⟩ Article dans une revue hal-00829351v1
Solid-phase synthesis of 5′-triphosphate 2′-5′-oligoadenylates analogs with 3′-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs. Yann Thillier,Sarah K Stevens,Christabel Moy,Taylor Joshua,Jean-Jacques Vasseuret al. Bioorganic and Medicinal Chemistry, 2013, 21 (17), pp.5461-5469. ⟨10.1016/j.bmc.2013.06.008⟩ Article dans une revue istex hal-00874543v1
Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome Barbara Selisko,Supanee Potisopon,Rym Agred,Stephane Priet,Isabelle Varletet al. PLoS Pathogens, 2012, 8 (9), pp.e1002912. ⟨10.1371/journal.ppat.1002912⟩ Article dans une revue hal-00733199v1
Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N 7)-methyl transferase Yann Thillier,Etienne Decroly,François Morvan,Bruno Canard,Jean-Jacques Vasseuret al. RNA, 2012, 18 (4), pp.856-868. ⟨10.1261/rna.030932.111⟩ Article dans une revue hal-00700861v1
FTIR and UV Spectroscopy Studies of Triplex Formation Between Pyrimidine Methoxyethylphosphoramidates α- Oligodeoxynucleotides and ds DNA Targets Bei-Wen Sun,Frédéric Geinguenaud,Eliane Taillandier,Magali Naval,Alain Laurentet al. Journal of Biomolecular Structure and Dynamics, 2012, 19 (6), pp.1073-1081. ⟨10.1080/07391102.2002.10506810⟩ Article dans une revue hal-04648544v1
Synthesis and Preliminary Evaluation of pro-RNA 2'-O-Masked with Biolabile Pivaloyloxymethyl Groups in an RNA Interference Assay Thomas Lavergne,Carine Baraguey,Christelle Dupouy,N. Parey,Winfried Wuenscheet al. Journal of Organic Chemistry, 2011, 76, pp.5719-5731. ⟨10.1021/jo200826h⟩ Article dans une revue hal-00616629v1
Efficient solid-phase chemical synthesis of 5'-triphosphates of DNA, RNA and their analogues. Ivan Zlatev,Thomas Lavergne,Françoise Debart,Jean-Jacques Vasseur,Muthiah Manoharanet al. Organic Letters, 2010, 12, pp.2190-2193. ⟨10.1021/ol1004214⟩ Article dans une revue hal-00519477v1
Chemical synthesis of RNA with base-labile 2'-O-(pivaloyloxymethyl)-protected ribonucleoside phosphoramidites. Thomas Lavergne,Michaël Janin,Christelle Dupouy,Jean-Jacques Vasseur,Françoise Debart Current Protocols in Nucleic Acid Chemistry, 2010, Supplement 43, pp.3.19.1-3.19.27. ⟨10.1002/0471142700.nc0319s43⟩ Article dans une revue hal-00556631v1
From anionic to cationic alpha-anomeric oligodeoxynucleotides. François Morvan,Françoise Debart,Jean-Jacques Vasseur Chemistry and Biodiversity, 2010, 7, pp.494-535. ⟨10.1002/cbdv.200900220⟩ Article dans une revue istex hal-00476462v1
Efficient release of base-sensitive oligonucleotides from solid supports using fluoride ions. T. Lavergne,N. Parey,J.-J. Vasseur,F. Debart European Journal of Organic Chemistry, 2009, pp.2190-2194. ⟨10.1002/ejoc.200801275⟩ Article dans une revue hal-00376886v1
Assessment of new 2'-O-acetalester protecting groups for regular RNA synthesis and original 2'-modified proRNA. Anthony R. Martin,Thomas Lavergne,Jean-Jacques Vasseur,Françoise Debart Bioorganic and Medicinal Chemistry Letters, 2009, 19, pp.4046-4049. ⟨10.1016/j.bmcl.2009.06.015⟩ Article dans une revue istex hal-00412360v1
A base labile group for 2'-OH protection of ribonucleosides : as a major challenge for RNA synthesis. T. Lavergne,J.-R. Bertrand,J.-J. Vasseur,F. Debart Chemistry - A European Journal, 2008, 14, pp.9135-9138. ⟨10.1002/chem.200801392⟩ Article dans une revue istex hal-00346580v1
5-propynylamino alpha-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic alpha-oligonucleotides. Gaëlle Deglane,François Morvan,Françoise Debart,Jean-Jacques Vasseur Bioorganic and Medicinal Chemistry Letters, 2007, 17, pp.951-954. ⟨10.1016/j.bmcl.2006.11.052⟩ Article dans une revue istex hal-00137368v1
Chemical modifications to improve the cellular uptake of oligonucleotides. Françoise Debart,Saïd Abes,Gaelle Deglane,Hong M Moulton,Philippe Clairet al. Current Topics in Medicinal Chemistry, 2007, 7 (7), pp.727-37. ⟨10.2174/156802607780487704⟩ Article dans une revue istex hal-00150534v1
Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding. Allison A. Johnson,Jane M. Sayer,Haruhiko Yagi,Sachindra S. Patil,Françoise Debartet al. Journal of Biological Chemistry, 2006, 281 (43), pp.32428-32438 Article dans une revue hal-00109066v1
Impact of the guanidinium group on hybridization and cellular uptake of cationic oligonucleotides. Gaëlle Deglane,Said Abes,Thibaud Michel,Paul Prevot,Eric Vivèset al. ChemBioChem, 2006, 7, pp.684-692 Article dans une revue hal-00022245v1
First evaluation of acyloxymethyl or acylthiomethyl groups as biolabile 2'-O-protections of RNA. Nora Parey,Carine Baraguey,Jean-Jacques Vasseur,Françoise Debart Organic Letters, 2006, 8, pp.3869-3872 Article dans une revue hal-00097408v1
Highly Stable DNA Triplexes Formed with Cationic Phosphoramidate Pyrimidine α‐Oligonucleotides Thibaut Michel,Francoise Debart,Frédéric Heitz,Jean-Jacques Vasseur ChemBioChem, 2005, 6 (7), pp.1254-1262. ⟨10.1002/cbic.200400436⟩ Article dans une revue hal-04600743v1
Toward high yield synthesis of peptide–oligonucleotide chimera through a disulfide bridge: A simplified method for oligonucleotide activation Frédéric Maurel,Françoise Debart,Florine Cavelier,Alain Thierry,Bernard Lebleuet al. Bioorganic and Medicinal Chemistry Letters, 2005, 15 (22), pp.5084-5087. ⟨10.1016/j.bmcl.2005.07.086⟩ Article dans une revue istex hal-03824545v1
Cationic phosphoramidate -oligonucleotides efficiently target single-stranded DNA and RNA and inhibit hepatitis C virus IRES-mediated translation Thibaut Michel,Camille Martinand-Mari,Francoise Debart,Bernard Lebleu,Ian Robbinset al. Nucleic Acids Research, 2003, 31 (18), pp.5282 - 5290. ⟨10.1093/nar/gkg733⟩ Article dans une revue hal-01878566v1
Efficient guanidination of the phosphate linkage towards cationic phosphoramidate oligonucleotides Thibaut Michel,Francoise Debart,Jean-Jacques Vasseur Tetrahedron Letters, 2003, 44 (35), pp.6579-6582. ⟨10.1016/S0040-4039(03)01694-0⟩ Article dans une revue hal-04600871v1
FTIR and UV Spectroscopy Studies of Triplex Formation Between α-Oligonucleotides with Non-Ionic Phoshoramidate Linkages and DNA Targets Thibault Michel,Francoise Debart,Jean-Jacques Vasseur,Frédéric Geinguenaud,Eliane Taillandier Journal of Biomolecular Structure and Dynamics, 2003, 21 (3), pp.435-445. ⟨10.1080/07391102.2003.10506938⟩ Article dans une revue hal-04648468v1
Synthesis, DNA binding and biological evaluation of synthetic precursors and novel analogs of netropsin Francoise Debart,Christian Périgaud,Gilles Gosselin,Driss Mrani,Bernard Rayneret al. Journal of Medicinal Chemistry, 2002, 32 (5), pp.1074-1083. ⟨10.1021/jm00125a024⟩ Article dans une revue istex hal-04652355v1
2-Amino-α-2′-deoxyadenosine increased duplex stability of methoxyethylphosphoramidate α-Oligodeoxynucleotides with RNA target Magali Naval,Thibaut Michel,Jean-Jacques Vasseur,Francoise Debart Bioorganic and Medicinal Chemistry Letters, 2002, 12 (11), pp.1435-1438. ⟨10.1016/s0960-894x(02)00215-9⟩ Article dans une revue hal-04600717v1
Use of MALDI-TOF mass spectrometry to monitor solid-phase synthesis of oligonucleotides T Guerlavais,Albert Meyer,Francoise Debart,J-L Imbach,François Morvanet al. Analytical and Bioanalytical Chemistry, 2002, 374 (1), pp.57-63. ⟨10.1007/s00216-002-1395-7⟩ Article dans une revue hal-04600638v1
Chiral and steric effects in the efficient binding of α α α α-anomeric deoxyoligonucleoside N-alkylphosphoramidates to ssDNA and RNA A. Laurent,Magali Naval,Françoise Debart,J.J. Vasseur,Bernard Rayner Nucleic Acids Research, 1999, 27 (21), pp.4151 - 4159. ⟨10.1093/nar/27.21.4151⟩ Article dans une revue hal-03008441v1
Anomeric inversion (from β to α) in methylphosphonate oligonucleosides enhances their affinity for DNA and RNA Françoise Debart,Albert Meyer,J.J. Vasseur,Bernard Rayner Nucleic Acids Research, 1998, 26 (20), pp.4551 - 4556. ⟨10.1093/nar/26.20.4551⟩ Article dans une revue hal-03008434v1
A new route to oligodeoxynucleoside phosphoramidates (PNH2) Alain Laurent,Francoise Debart,Bernard Rayner Tetrahedron Letters, 1997, 38 (30), pp.5285-5288. ⟨10.1016/S0040-4039(97)01153-2⟩ Article dans une revue istex hal-04648599v1
Esterase-triggered fluorescence of fluorogenic oligonucleotides Alain Laurent,Francoise Debart,Ned J. Lamb,Bernard Rayner Bioconjugate Chemistry, 1997, 8 (6), pp.856-861. ⟨10.1021/bc970168i⟩ Article dans une revue hal-04600699v1
Chimeric alpha‐beta oligonucleotides as antisense inhibitors of reverse transcription Claudine Boiziau,Françoise Debart,Bernard Rayner,Jean-Louis Imbach,Jean-Jacques Toulme FEBS Letters, 1995, 361 (1), pp.41-45. ⟨10.1016/0014-5793(95)00138-y⟩ Article dans une revue istex hal-04650399v1
Optimization of hybridizing abilities and nuclease resistance in the design of chimeric α-anomeric oligodeoxynucleotides containing β-anomeric gaps Francoise Debart,Guilhem Tosquellas,Bernard Rayner,Jean-Louis Imbach Bioorganic and Medicinal Chemistry Letters, 1994, 4 (8), pp.1041-1046. ⟨10.1016/S0960-894X(01)80678-8⟩ Article dans une revue istex hal-04651101v1
Efficient and Stereoselective Synthesis of 3′-Deoxy 3′ - C -Branched-Chain Substituted Thymidine Yogesh Sanghvi,Ramesh Bharadwaj,Francoise Debart,Alain de Mesmaeker Synthesis: Journal of Synthetic Organic Chemistry, 1994, 1994 (11), pp.1163-1166. ⟨10.1055/s-1994-25664⟩ Article dans une revue hal-04650441v1
Synthesis and base-pairing properties of the nuclease-resistant α-anomeric dodecaribonucleotide α-[r(UCUUAACCCACA)] Francoise Debart,Bernard Rayner,Genevieve Degols,Jean-Louis Imbach Nucleic Acids Research, 1992, 20 (6), pp.1193-1200. ⟨10.1093/nar/20.6.1193⟩ Article dans une revue hal-04651171v1
Intermolecular radical C-C bond formation: Synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides Francoise Debart,Jean-Jacques Vasseur,Yogesh Sanghvi,P. Dan Cook Tetrahedron Letters, 1992, 33 (19), pp.2645-2648. ⟨10.1016/S0040-4039(00)79047-2⟩ Article dans une revue istex hal-04651127v1
Synthesis and incorporation of methyleneoxy(methylimino) linked thymidine dimer into antisense oligonucleosides Francoise Debart,Jean-Jacques Vasseur,Yogesh Sanghvi,P. Dan Cook Bioorganic and Medicinal Chemistry Letters, 1992, 2 (12), pp.1479-1482. ⟨10.1016/S0960-894X(00)80412-6⟩ Article dans une revue istex hal-04651150v1
Caractérisation de nouveaux dérivés et analogues de la nétropsine et identification de leurs intermédiaires de synthèse par spectrométrie de masse FAB Jean‐Louis Aubagnac,Francoise Debart,Driss Mrani,Gilles Gosselin,Bernard Rayneret al. Journal of Heterocyclic Chemistry, 1991, 28 (1), pp.145-151. ⟨10.1002/jhet.5570280126⟩ Article dans une revue istex hal-04600793v1
Synthesis, DNA binding properties and biological evaluation of novel oligo-meta-benzamides related to netropsin Francoise Debart,Gilles Gosselin,Bernard Rayner,P Le Ber,C Auclairet al. European Journal of Medicinal Chemistry, 1991, 26 (3), pp.261-271. ⟨10.1016/0223-5234(91)90058-U⟩ Article dans une revue hal-04651228v1
Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents Francoise Debart,Bernard Rayner,Jeon-Louis Imbach Tetrahedron Letters, 1990, 31 (25), pp.3537-3540. ⟨10.1016/S0040-4039(00)94436-8⟩ Article dans une revue istex hal-04600829v1
Structure and Conformation of the Duplex Consensus 5′-Splice Site d [(CpApGpGpTpApApGpT) (ApCpTpTpApCpCpTpG)] Deduced from High Field 1 H-NMR of the Non-Exchangeable and Imino Protons Francoise Debart,Bernard Rayner,Jean-Louis Imbach,Moses Lee,Ding-Kwo Changet al. Journal of Biomolecular Structure and Dynamics, 1987, 5 (1), pp.47-65. ⟨10.1080/07391102.1987.10506374⟩ Article dans une revue hal-04652389v1
Structure and Conformation of the Duplex Consensus Acceptor Exon: Intron Junction d [(CpTpApCpApGpGpT) (ApCpCpTpGpTpApG)] deduced from High-Field 1 H-NMR of Non-Exchangeable and Imino Protons Francoise Debart,Bernard Rayner,Jean-Louis Imbach,Ding-Kwo Chang,J. William Lown Journal of Biomolecular Structure and Dynamics, 1986, 4 (3), pp.343-363. ⟨10.1080/07391102.1986.10506354⟩ Article dans une revue hal-04652415v1
1 H and 31 P-NMR Assignments of the Non-exchangeable Protons of the Consensus Acceptor Exon: Intron Junction d(CpTpApCpApGpGpT) J. William Lown,Ding-Kwo Chang,Francoise Debart,Bernard Rayner,Jean-Louis Imbach Journal of Biomolecular Structure and Dynamics, 1986, 3 (6), pp.1171-1187. ⟨10.1080/07391102.1986.10508493⟩ Article dans une revue hal-04652404v1

Chapitre d'ouvrage (1)

From Anionic to Cationic Alpha-Oligodeoxynucleosides F. Morvan,F. Debart,J.-J. Vasseur Martin Egli, Piet Herdewijn. Chemistry and Biology of Nucleic Acids, Verlag Helvetica Chemica Acta, Zürich, Switzerland in Wiley-VCH, Weinheim, Federal Republic Germany, pp.79-120, 2012 Chapitre d'ouvrage hal-00676559v1

Brevet (1)

Chemical RNA Synthesis Method Françoise Debart,Jean-Jacques Vasseur,Thomas Lavergne Patent n° : US 2011/0275793 A1. 2011 Brevet hal-00643530v1