Frédéric Becq Professeur de Physiologie, Université de Poitiers

Publications

Article dans une revue (106)

Peptide CIGB‐552 has a synergistic effect on CFTR‐F508del when combined with elexacaftor/tezacaftor/ivacaftor triple therapy for cystic fibrosis Benjamin Simonneau,Stéphanie Simon,Bénédicte Duriez,Aurélie Guguin,Frédéric Becqet al. British Journal of Pharmacology, 2025, ⟨10.1111/bph.70169⟩ Article dans une revue hal-05215781v1
Effect of elexacaftor and bamocaftor on the metabolic and thermal stability of the F508del-CFTR protein in human airway epithelial cells Thomas Carrez,Sandra Mirval,Christine Barrault,Florian Devetter,Clarisse Vandebroucket al. American Journal of Physiology - Lung Cellular and Molecular Physiology, 2025, ⟨10.1152/ajplung.00011.2025⟩ Article dans une revue hal-05216356v1
Impact of hypoxia in Cystic Fibrosis bronchial epithelial cells: Focus on CFTR and TRPA1 channels Khilian Pascarel,Jenny Colas,Thomas Carrez,Sandra Mirval,Christine Barraultet al. Revue des Maladies Respiratoires, 2024, 41 (3), pp.226. ⟨10.1016/j.rmr.2024.01.089⟩ Article dans une revue hal-04822274v1
Effect of hypoxia on Cystic Fibrosis Transmembrane conductance Regulator channel corrected by Elexacaftor/Tezacaftor/Ivacaftor Khilian Pascarel,Jenny Colas,Thomas Carrez,Christine Barrault,Sandra Mirvalet al. Medical Research Archives, 2024, 12 (2), ⟨10.18103/mra.v12i2.4909⟩ Article dans une revue hal-04496971v1
The F508del-CFTR trafficking correctors elexacaftor and tezacaftor are CFTR-independent Ca2+-mobilizing agonists normalizing abnormal Ca2+ levels in human airway epithelial cells Manuella Lévêque,Sandra Mirval,Christine Barrault,Isabelle Fixe,Christelle Corauxet al. Respiratory Research, 2024, 25 (1), pp.436. ⟨10.1186/s12931-024-03059-8⟩ Article dans une revue hal-04852924v1
ABC transporters involved in respiratory and cholestatic diseases: From rare to very rare monogenic diseases Mounia Lakli,Marion Onnée,Thomas Carrez,Frédéric Becq,Thomas Falguièreset al. Biochemical Pharmacology, 2024, 229, pp.116468. ⟨10.1016/j.bcp.2024.116468⟩ Article dans une revue hal-05490923v1
The impact of hypoxia on the ion channels in cystic fibrosis bronchial epithelial cells K. Pascarel,J. Colas,S. Mirval,F. Becq,C. Vandebrouck Revue des Maladies Respiratoires, 2023, 40 (3), pp.230-233. ⟨10.1016/j.rmr.2023.01.014⟩ Article dans une revue hal-04040380v1
The multi-faceted nature of 15 CFTR exonic variations: Impact on their functional classification and perspectives for therapy Anne Bergougnoux,A. Billet,C. Ka,M. Heller,F. Degrugillieret al. Journal of Cystic Fibrosis, 2022, ⟨10.1016/j.jcf.2022.12.003⟩ Article dans une revue hal-03913493v1
The rescue of F508del-CFTR by elexacaftor/tezacaftor/ivacaftor (Trikafta) in human airway epithelial cells is underestimated due to the presence of ivacaftor Frédéric Becq,Sandra Mirval,Thomas Carrez,Manuella Lévêque,Arnaud Billetet al. European Respiratory Journal, 2022, 59 (2), pp.2100671. ⟨10.1183/13993003.00671-2021⟩ Article dans une revue hal-04352015v1
Myelinosome organelles in the retina of r6/1 huntington disease (Hd) mice: ubiquitous distribution and possible role in disease spreading Marina Yefimova,Emile Béré,Anne Cantereau,Annie-Claire Balandre,Bruno Merceronet al. International Journal of Molecular Sciences, 2021, 22 (23), pp.12771. ⟨10.3390/ijms222312771⟩ Article dans une revue hal-03468899v2
CFTR et mucoviscidose, une histoire cinquantenaire Frédéric Becq Médecine/Sciences, 2021, 37 (6-7), pp.654-659. ⟨10.1051/medsci/2021089⟩ Article dans une revue hal-03273144v1
Phospholipase C controls chloride-dependent short-circuit current in human bronchial epithelial cells Chloé Grebert,Frédéric Becq,Clarisse Vandebrouck American Journal of Physiology - Lung Cellular and Molecular Physiology, 2021, 320 (2), pp.L205-L219. ⟨10.1152/ajplung.00437.2019⟩ Article dans une revue hal-04040390v1
Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension Hélène Le Ribeuz,Lucie To,Maria-Rosa Ghigna,Clémence Martin,Chandran Nagarajet al. European Respiratory Journal, 2021, 58 (5), pp.2000653. ⟨10.1183/13993003.00653-2020⟩ Article dans une revue hal-03499886v1
Functional and Pharmacological Characterization of the Rare CFTR Mutation W361R Arnaud Billet,Ahmad Elbahnsi,Mathilde Jollivet-Souchet,Brice Hoffmann,Jean-Paul Mornonet al. Frontiers in Pharmacology, 2020, 11, ⟨10.3389/fphar.2020.00295⟩ Article dans une revue hal-02557014v1
Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity Lionel Froux,Ahmad Elbahnsi,Benjamin Boucherle,Arnaud Billet,Nesrine Baatallahet al. European Journal of Medicinal Chemistry, 2020, 190, pp.112116. ⟨10.1016/j.ejmech.2020.112116⟩ Article dans une revue hal-02924784v1
Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells Jodie Llinares,Anne Cantereau,Lionel Froux,Frédéric Becq PLoS ONE, 2020, 15 (5), pp.e0233439. ⟨10.1371/journal.pone.0233439⟩ Article dans une revue hal-03113355v1
Focus on TRP channels in cystic fibrosis Chloé Grebert,Frederic Becq,Clarisse Vandebrouck Cell Calcium, 2019, 81, pp.29 - 37. ⟨10.1016/j.ceca.2019.05.007⟩ Article dans une revue hal-03484344v1
Short-term consequences of F508del-CFTR thermal instability on CFTR-dependent transepithelial currents in human airway epithelial cells Lionel Froux,Christelle Coraux,Edouard Sage,Frédéric Becq Scientific Reports, 2019, 9 (1), pp.13729. ⟨10.1038/s41598-019-50066-7⟩ Article dans une revue hal-04541618v1
Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility M Yefimova,Nicolas Bourmeyster,F Becq,A Burel,M-T Lavaultet al. Morphologie, 2019, 103 (341), pp.4-10. ⟨10.1016/j.morpho.2018.11.001⟩ Article dans une revue hal-01976465v1
Transalpinecine and Analogues: First Total Synthesis, Stereochemical Revision and Biological Evaluation Cécile Baudoin-Dehoux,Tessa Castellan,Morgane Enel,Christiane André-Barrès,Sandra Mirvalet al. European Journal of Organic Chemistry, 2019, 19, pp.1830-1834. ⟨10.1002/ejoc.201900071⟩ Article dans une revue hal-02330547v1
Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases Linette Kadri,Romain Ferru-Clément,Amélie Bacle,Laurie-Anne Payet,Anne Cantereauet al. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2018, 1864 (9), pp.3069-3084. ⟨10.1016/j.bbadis.2018.06.021⟩ Article dans une revue istex hal-04541917v1
Modulating the cystic fibrosis transmembrane regulator and the development of new precision drugs Lionel Froux,Arnaud Billet,Frédéric Becq Expert Review of Precision Medicine and Drug Development, 2018, 3 (6), pp.357-370. ⟨10.1080/23808993.2018.1547109⟩ Article dans une revue hal-03192898v1
In cellulo analyses of the p.Val322Ala mutation on the CFTR protein conformation and activity Raëd Farhat,Ayman El-Seedy,Ariestya Indah Permata Sari,Caroline Norez,Marie-Claude Pasquetet al. Comptes Rendus. Biologies, 2017, 340 (8), pp.367-371. ⟨10.1016/j.crvi.2017.06.001⟩ Article dans une revue hal-04541918v1
Heterozygous mutation of CFTR gene leads to activation of autophagy in Sertoli cells C. Ravel,Nicolas Bourmeyster,F. Becq,A. Burel,M. T. Lavaultet al. Human Reproduction, 2017, 32 (suppl_1), pp.i159-i159. ⟨10.1093/humrep/32.Supplement_1.1⟩ Article dans une revue hal-01688588v1
Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function Arnaud Billet,Lionel Froux,John Hanrahan,Frederic Becq Frontiers in Pharmacology, 2017, 8, pp.195. ⟨10.3389/fphar.2017.00195⟩ Article dans une revue hal-03191777v1
Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention Réginald Philippe,Fabrice Antigny,Paul Buscaglia,Caroline Norez,Florentin Huguetet al. Cell Calcium, 2017, 62, pp.47-59. ⟨10.1016/j.ceca.2017.01.011⟩ Article dans une revue istex hal-04541923v1
Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis Laurent Meijer,Deborah Nelson,Vladimir Riazanski,Aida Gabdoulkhakova,Geneviève Héry-Arnaudet al. Journal of Innate Immunity, 2016, 8 (4), pp.330-349. ⟨10.1159/000444256⟩ Article dans une revue hal-02042979v1
The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection. Claire Chevaleyre,Mickaël Riou,Deborah Brea,Clarisse Vandebrouck,Céline Barcet al. PLoS ONE, 2016, 11 (12), pp.e0168577. ⟨10.1371/journal.pone.0168577⟩ Article dans une revue hal-01437131v1
Targeting surface voids to counter membrane disorders in lipointoxication-related diseases. Romain Ferru-Clément,Miroslava Spanova,Shalinee Dhayal,Noel G Morgan,Reynald Hélyeet al. Journal of Cell Science, 2016, 129 (12), pp.2368-81. ⟨10.1242/jcs.183590⟩ Article dans une revue hal-01337179v1
Pushing the limits of catalytic C–H amination in polyoxygenated cyclobutanes Pierre-Antoine Nocquet,Raphael Hensienne,Joanna Wencel-Delord,Eugénie Laigre,Khadidja Sidelarbiet al. Organic & Biomolecular Chemistry, 2016, 14 (9), pp.2780-2796. ⟨10.1039/C5OB02602D⟩ Article dans une revue hal-02410808v1
Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR Marina Yefimova,Emile Béré,Anne Cantereau-Becq,Thomas Harnois,Annie-Claire Meunieret al. Human Molecular Genetics, 2016, 25 (19), pp.4170-4185. ⟨10.1093/hmg/ddw251⟩ Article dans une revue hal-03686913v1
The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity Laura Vachel,Caroline Norez,Christophe Jayle,Frédéric Becq,Clarisse Vandebrouck Cell Calcium, 2015, 57 (1), pp.38-48. ⟨10.1016/j.ceca.2014.11.005⟩ Article dans une revue istex hal-04541945v1
Predicting CFTR activity with front-runner cystic fibrosis drugs Frédéric Becq EBioMedicine, 2015, 2 (2), pp.100-101. ⟨10.1016/j.ebiom.2015.01.013⟩ Article dans une revue hal-01177773v1
SERCA and PMCA pumps contribute to the deregulation of Ca(2+) homeostasis in human CF epithelial cells. Réginald Philippe,Fabrice Antigny,Paul Buscaglia,Caroline Norez,Frédéric Becqet al. Biochimica et Biophysica Acta - Molecular Cell Research, 2015, 1853 (5), pp.892-903. ⟨10.1016/j.bbamcr.2015.01.010⟩ Article dans une revue istex hal-01134260v1
Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors. V. Cendret,T. Legigan,A. Martin-Mingot,S. Thibaudeau,I. Adachiet al. Organic & Biomolecular Chemistry, 2015, 13 (43), pp.10734-10744. ⟨10.1039/c5ob01526j⟩ Article dans une revue hal-01500682v1
A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells Johanna Bertrand,Luc Dannhoffer,Fabrice Antigny,Laura Vachel,Christophe Jayleet al. European Journal of Pharmacology, 2015, 765, pp.337-345. ⟨10.1016/j.ejphar.2015.08.005⟩ Article dans une revue hal-04541933v1
Vasorelaxation induced by dodoneine is mediated by calcium channels blockade and carbonic anhydrase inhibition on vascular smooth muscle cells Grégoire Carre,Maurice Ouedraogo,Christophe Magaud,Hélène Carreyre,Frédéric Becqet al. Journal of Ethnopharmacology, 2015, 169, pp.8-17. ⟨10.1016/j.jep.2015.03.037⟩ Article dans une revue istex hal-04541937v1
Involvement of the Cdc42 Pathway in CFTR Post-Translational Turnover and in Its Plasma Membrane Stability in Airway Epithelial Cells Romain Ferru-Clément,Fleur Fresquet,Caroline Norez,Thierry Métayé,Frédéric Becqet al. PLoS ONE, 2015, 10, pp.e0118943. ⟨10.1371/journal.pone.0118943⟩ Article dans une revue hal-01141771v1
Function, pharmacological correction and maturation of new Indian CFTR gene mutations Himanshu Sharma,Mathilde Jollivet Souchet,Isabelle Callebaut,Rajendra Prasad,Frédéric Becq Journal of Cystic Fibrosis, 2015, 14 (1), pp.34-41. ⟨10.1016/j.jcf.2014.06.008⟩ Article dans une revue hal-01099879v1
N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors J. Désiré,M. Mondon,N. Fontelle,S. Nakagawa,Y. Hirokamiet al. Organic & Biomolecular Chemistry, 2014, 12 (44), pp.8977-8996. ⟨10.1039/c4ob00325j⟩ Article dans une revue hal-01311606v1
Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation Laurie-Anne Payet,Linette Kadri,Sébastien Giraud,Caroline Norez,Jean Marc Berjeaudet al. PLoS ONE, 2014, 9 (2), pp.e89044. ⟨10.1371/journal.pone.0089044⟩ Article dans une revue hal-00990346v1
Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells. Nathalie Benz,Sophie Le Hir,Caroline Norez,Mathieu Kerbiriou,Marie-Laure Calvezet al. PLoS ONE, 2014, 9 (2), pp.e88964. ⟨10.1371/journal.pone.0088964⟩ Article dans une revue hal-00990343v1
The human CFTR protein expressed in CHO cells activates aquaporin-3 in a cAMP-dependent pathway: study by digital holographic microscopy. Pascal Jourdain,Frédéric Becq,Sylvain Lengacher,Clément Boinot,Pierre J Magistrettiet al. Journal of Cell Science, 2014, 127 (Pt 3), pp.546-56. ⟨10.1242/jcs.133629⟩ Article dans une revue hal-00990312v1
Bronchorelaxation of the human bronchi by CFTR activators Caroline Norez,Christophe Jayle,Frédéric Becq,Clarisse Vandebrouck Pulmonary Pharmacology and Therapeutics, 2014, 27 (1), pp.38-43. ⟨10.1016/j.pupt.2013.06.008⟩ Article dans une revue istex hal-04040435v1
Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism C Norez,C. Vandebrouck,J Bertrand,S Noel,E Durieuet al. British Journal of Pharmacology, 2014, 171 (21), pp.4831-4849. ⟨10.1111/bph.12859⟩ Article dans une revue hal-04041398v1
The hypotensive agent dodoneine inhibits L-type Ca2+ current with negative inotropic effect on rat heart. Grégoire Carré,Hélène Carreyre,Maurice Ouedraogo,Frédéric Becq,Patrick Boiset al. European Journal of Pharmacology, 2014, 728, pp.119-27. ⟨10.1016/j.ejphar.2014.01.059⟩ Article dans une revue istex hal-00990335v1
ANO1 contributes to angiotensin-II-activated Ca2+-dependent Cl- current in human atrial fibroblasts. Antoun El Chemaly,Caroline Norez,Christophe Magaud,Jocelyn Bescond,Aurelien Chatelieret al. Journal of Molecular and Cellular Cardiology, 2014, 68, pp.12-9. ⟨10.1016/j.yjmcc.2013.12.027⟩ Article dans une revue istex hal-00990329v1
Effect of VX-770 (ivacaftor) and OAG on Ca2+ influx and CFTR activity in G551D and F508del-CFTR expressing cells. Laura Vachel,Caroline Norez,Frédéric Becq,Clarisse Vandebrouck Journal of Cystic Fibrosis, 2013, 12 (6), pp.584-91. ⟨10.1016/j.jcf.2013.05.008⟩ Article dans une revue hal-00990531v1
CFTR: Effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel Arnaud Billet,Jean-Paul Mornon,Mathilde Jollivet,Pierre Lehn,Isabelle Callebautet al. Journal of Cystic Fibrosis, 2013, 12, pp.737-745. ⟨10.1016/j.jcf.2013.02.002⟩ Article dans une revue istex hal-00907930v1
C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat. Sarah F Jenkinson,Daniel Best,a Waldo Saville,James Mui,R Fernando Martínezet al. Journal of Organic Chemistry, 2013, 78 (15), pp.7380-97. ⟨10.1021/jo4005487⟩ Article dans une revue hal-00990546v1
Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia. Thassadite Dirami,Baptiste Rode,Mathilde Jollivet,Nathalie da Silva,Denise Escalieret al. American Journal of Human Genetics, 2013, 92 (5), pp.760-6. ⟨10.1016/j.ajhg.2013.03.016⟩ Article dans une revue hal-00990664v1
Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors. Philippe Compain,Camille Decroocq,Antoine Joosten,Julien de Sousa,David Rodríguez-Lucenaet al. ChemBioChem, 2013, 14 (15), pp.2050-8. ⟨10.1002/cbic.201300312⟩ Article dans une revue istex hal-00990168v1
Strategies to circumvent the CFTR defect in cystic fibrosis. Frédéric Becq,Marc Chanson Frontiers in Pharmacology, 2013, 4, pp.108. ⟨10.3389/fphar.2013.00108⟩ Article dans une revue hal-00990355v1
Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain Norbert Odolczyk,Janine Fritsch,Caroline Norez,Nathalie Servel,Melanie Faria da Cunhaet al. EMBO Molecular Medicine, 2013, 5 (10), pp.1484 - 1501. ⟨10.1002/emmm.201302699⟩ Article dans une revue hal-00990522v1
Saturated fatty acids alter the late secretory pathway by modulating membrane properties. Laurie-Anne Payet,Ludovic Pineau,Ellen C R Snyder,Jenny Colas,Ahmed Moussaet al. Traffic, 2013, 14 (12), pp.1228-41. ⟨10.1111/tra.12117⟩ Article dans une revue hal-00990166v1
CFTR mutation combinations producing frequent complex alleles with different clinical and functional outcomes Ayman El-Seedy,Emmanuelle Girodon,Caroline Norez,Julie Pajaud,Marie-Claude Pasquetet al. Human Mutation, 2012, 33 (11), pp.1557-1565. ⟨10.1002/humu.22129⟩ Article dans une revue istex hal-02446189v1
Deficit of osteoprotegerin release by osteoblasts from a patient with cystic fibrosis. Annelise Gimenez-Maitre,Carole Le Henaff,Caroline Norez,Christine Guillaume,Bruno Ravoninjatovoet al. European Respiratory Journal, 2012, 39 (3), pp.780-1. ⟨10.1183/09031936.00104111⟩ Article dans une revue inserm-00602058v1
4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group. Filipa P da Cruz,Scott Newberry,Sarah F Jenkinson,Mark R Wormald,Terry D Butterset al. Tetrahedron Letters, 2011, 52 (2), pp.219-223. ⟨10.1016/j.tetlet.2010.10.173⟩ Article dans une revue hal-00580432v1
From the vasodilator and hypotensive effects of an extract fraction from Agelanthus dodoneifolius (DC) Danser (Loranthaceae) to the active compound dodoneine Maurice Ouedraogo,M. Ruiz,E. Vardelle,Hélène Carreyre,Jean-Marie Coustardet al. Journal of Ethnopharmacology, 2011, 133 (2), pp.345-352. ⟨10.1016/j.jep.2010.10.002⟩ Article dans une revue istex hal-00560900v1
CFTR and Ca2+ Signaling in Cystic Fibrosis Fabrice Antigny,Caroline Norez,Frédéric Becq,Clarisse Vandebrouck Frontiers in Pharmacology, 2011, 2, pp.67. ⟨10.3389/fphar.2011.00067⟩ Article dans une revue hal-00664651v1
An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors. Brice-Loïc Renard,Benjamin Boucherle,Bruno Maurin,Marie-Carmen Molina,Caroline Norezet al. European Journal of Medicinal Chemistry, 2011, 46 (5), pp.1935-41. ⟨10.1016/j.ejmech.2011.02.037⟩ Article dans une revue istex hal-00582439v1
Transient receptor potential canonical channel 6 links Ca2+ mishandling to cystic fibrosis transmembrane conductance regulator channel dysfunction in cystic fibrosis. Fabrice Antigny,Caroline Norez,Luc Dannhoffer,Johanna Bertrand,Dorothée Raveauet al. American Journal of Respiratory Cell and Molecular Biology, 2011, 44 (1), pp.83-90. ⟨10.1165/rcmb.2009-0347OC⟩ Article dans une revue hal-00559252v1
Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain. Nicolas Ardes-Guisot,Dominic S Alonzi,Gabriele Reinkensmeier,Terry D Butters,Caroline Norezet al. Organic & Biomolecular Chemistry, 2011, 9 (15), pp.5373-5388. ⟨10.1039/c1ob05119a⟩ Article dans une revue hal-00608881v1
Stimulation of wild-type, F508del- and G551D-CFTR chloride channels by non-toxic modified pyrrolo[2,3-b]pyrazine derivatives Luc Dannhoffer,Arnaud Billet,Mathilde Jollivet-Souchet,Patricia Melin-Heschel,Christelle Faveauet al. Frontiers in Pharmacology, 2011, 2, ⟨10.3389/fphar.2011.00048⟩ Article dans une revue hal-03192023v1
Orphan Missense Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator Fleur Fresquet,Romain Clement,Caroline Norez,Adélaïde Sterlin,Patricia Melinet al. Journal of Molecular Diagnostics, 2011, 13 (5), pp.520-527. ⟨10.1016/j.jmoldx.2011.05.004⟩ Article dans une revue hal-04564655v1
Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a. J. Bertrand,B. Boucherle,A. Billet,P. Melin-Heschel,L. Dannhofferet al. European Respiratory Journal, 2010, 36 (2), pp.311-22. ⟨10.1183/09031936.00122509⟩ Article dans une revue hal-00559199v1
Understanding nucleotide binding and CFTR ion channel gating: how many cycles? Frédéric Becq,Arnaud Billet Expert Review of Respiratory Medicine, 2010, 4 (4), pp.451-4. ⟨10.1586/ers.10.47⟩ Article dans une revue hal-00561612v1
CFTR channels and adenosine triphosphate release: the impossible rendez-vous revisited in skeletal muscle. Frédéric Becq The Journal of Physiology, 2010, 588 (Pt 23), pp.4605-6. ⟨10.1113/jphysiol.2010.200113⟩ Article dans une revue hal-00582430v1
Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia. Ophélia Granio,Katherine J D Ashbourne Excoffon,Petra Henning,Patricia Melin,Caroline Norezet al. Human Gene Therapy, 2010, 21 (3), pp.251-69. ⟨10.1089/hum.2009.056⟩ Article dans une revue hal-00580553v1
Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars Daniel Best,Sarah F Jenkinson,Waldo A. Saville,Dominic S Alonzi,Mark R Wormaldet al. Tetrahedron Letters, 2010, 51 (32), pp.4170-4174. ⟨10.1016/j.tetlet.2010.05.131⟩ Article dans une revue istex hal-00580537v1
Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: progress to date. Frédéric Becq Drugs, 2010, 70 (3), pp.241-59. ⟨10.2165/11316160-000000000-00000⟩ Article dans une revue hal-00582426v1
C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation. Arnaud Billet,Patricia Melin,Mathilde Jollivet,Jean-Paul Mornon,Isabelle Callebautet al. Journal of Biological Chemistry, 2010, 285 (29), pp.22132-40. ⟨10.1074/jbc.M110.120683⟩ Article dans une revue hal-00582442v1
Dysfunction of mitochondria Ca2+ uptake in cystic fibrosis airway epithelial cells Fabrice Antigny,Nathalie Girardin,Dorothée Raveau,Maud Frieden,Frédéric Becqet al. Mitochondrion, 2009, 9 (4), pp.232-241. ⟨10.1016/j.mito.2009.02.003⟩ Article dans une revue istex hal-04040455v1
A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype. Caroline Norez,Fabrice Antigny,Sabrina Noel,Clarisse Vandebrouck,Frédéric Becq American Journal of Respiratory Cell and Molecular Biology, 2009, 41 (2), pp.217-225. ⟨10.1165/rcmb.2008-0285OC⟩ Article dans une revue hal-00444213v1
Rescue of functional F508del cystic fibrosis transmembrane conductance regulator by vasoactive intestinal peptide in the human nasal epithelial cell line JME/CF15. Sara Rafferty,Nicole Alcolado,Caroline Norez,Frederic Chappe,Siegried Pelzeret al. Journal of Pharmacology and Experimental Therapeutics, 2009, 331 (1), pp.2-13 Article dans une revue hal-00444202v1
SiRNA calnexin promotes endogenous F508del-CFTR trafficking D. Raveau,A. Cantereau,F. Becq,C. Norez Journal of Cystic Fibrosis, 2009, 8, pp.S19. ⟨10.1016/S1569-1993(09)60078-3⟩ Article dans une revue hal-03119993v1
Anti-inflammatory effect of miglustat in bronchial epithelial cells Maria Cristina Decheccchi,Elena Nicolis,Caroline Norez,Valentino Bezzerri,Monica Borgattiet al. Journal of Cystic Fibrosis, 2008, 7 (6), pp.555-565. ⟨10.1016/j.jcf.2008.06.002⟩ Article dans une revue hal-00392599v1
Proteasome-Dependent Pharmacological Rescue of Cystic Fibrosis Transmembrane Conductance Regulator Revealed by Mutation of Glycine 622 Caroline Norez,Frédéric Bilan,Alain Kitzis,Yvette Mettey,Frédéric Becq Journal of Pharmacology and Experimental Therapeutics, 2008, 25 (1), pp.89-99. ⟨10.1124/jpet.107.134502⟩ Article dans une revue hal-00392917v1
Guanabenz, an α2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells Caroline Norez,Clarisse Vandebrouck,Fabrice Antigny,Luc Dannhoffer,Marc Blondelet al. European Journal of Pharmacology, 2008, 592 (1-3), pp.33-40. ⟨10.1016/j.ejphar.2008.06.103⟩ Article dans une revue istex hal-00392424v1
Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells. Frédéric Bilan,Magali Nacfer,Fleur Fresquet,Caroline Norez,Patricia Melinet al. Experimental Cell Research, 2008, 314 (11-12), pp.2199-2211. ⟨10.1016/j.yexcr.2008.04.012⟩ Article dans une revue istex hal-00399077v1
9-Phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels Teddy Grand,Marie Demion,Caroline Norez,Yvette Mettey,Pierre Launayet al. British Journal of Pharmacology, 2008, 153 (8), pp.1697-1705. ⟨10.1038/bjp.2008.38⟩ Article dans une revue hal-00393981v1
Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells Fabrice Antigny,Caroline Norez,Anne Cantereau,Frédéric Becq,Clarisse Vandebrouck Respiratory Research, 2008, 9 (1), pp.70. ⟨10.1186/1465-9921-9-70⟩ Article dans une revue hal-03119859v1
Stimulation of salivary secretion in vivo by CFTR potentiators in Cftr+/+ and Cftr−/− mice Sabrina Noël,Pierre-Olivier Strale,Luc Dannhoffer,Martina Wilke,Hugo Dejongeet al. Journal of Cystic Fibrosis, 2008, 7 (2), pp.128-133. ⟨10.1016/j.jcf.2007.06.005⟩ Article dans une revue istex hal-00402063v1
Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells. Sabrina Noël,Martina Wilke,Alice G. M. Bot,Hugo R. de Jonge,Frédéric Becq Journal of Pharmacology and Experimental Therapeutics, 2008, 325 (1), pp.1016-1023. ⟨10.1124/jpet.107.135582⟩ Article dans une revue hal-00402085v1
Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high affinity inhibitors of CFTR chloride channels. C. Routaboul,C. Norez,P. Melin,M.-C. Molina,B. Boucherleet al. J. Pharmacol. Exp. Ther., 2007, pp.1023-1035. ⟨10.1124/jpet.107.123307⟩ Article dans une revue hal-00383202v1
MPB-07 Reduces the Inflammatory Response to Pseudomonas aeruginosa in CF Bronchial Cells Maria Cristina Dechecchi,Elena Nicolis,Valentino Bezzerri,Antonio Vella,Marco Colombattiet al. American Journal of Respiratory Cell and Molecular Biology, 2007, 36 (5), pp.615-624. ⟨10.1165/rcmb.2006-0200OC⟩ Article dans une revue hal-00401637v1
Cellular Localization and Activity of Ad-Delivered GFP-CFTR in Airway Epithelial and Tracheal Cells Ophélia Granio,Caroline Norez,Katherine J.D. Ashbourne Excoffon,Philip H. Karp,Monika Luskyet al. American Journal of Respiratory Cell and Molecular Biology, 2007, 37, pp.631-639. ⟨10.1165/rcmb.2007-0026TE⟩ Article dans une revue hal-00392684v1
Structure Elucidation of a Dihydropyranone from Tapinanthus dodoneifolius Maurice Ouedraogo,Hélène Carreyre,Clarisse Vandebrouck,Jocelyn Bescond,Guy Raymondet al. Journal of Natural Products, 2007, 70 (12), pp.2006-2009. ⟨10.1021/np070355x⟩ Article dans une revue istex hal-00389669v1
Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel Céline Auzanneau,Caroline Norez,Fabrice Antigny,Vincent Thoreau,Chantal Jouglaet al. Biochemical Pharmacology, 2007, 75 (2), pp.476-483. ⟨10.1016/j.bcp.2007.09.004⟩ Article dans une revue istex hal-00389815v1
Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries. Robert Renaud,Jean Pierre Savineau,Caroline Norez,Frederic Becq,Christelle Guibert European Respiratory Journal, 2007, ⟨10.1183/09031936.00060007⟩ Article dans une revue hal-02439706v1
NHE-RF1 protein rescues DeltaF508-CFTR function Florian Bossard,Amal Robay,Gilles Toumaniantz,Shehrazade Dahimene,Frédéric Becqet al. American Journal of Physiology - Lung Cellular and Molecular Physiology, 2007, 292 (5), pp.1085-1094. ⟨10.1152/ajplung.00445.2005⟩ Article dans une revue hal-00401936v1
Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR Fabrice Antigny,Caroline Norez,Frédéric Becq,Clarisse Vandebrouck Cell Calcium, 2007, 43 (2), pp.175-183. ⟨10.1016/j.ceca.2007.05.002⟩ Article dans une revue istex hal-00389764v1
CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three Patricia Melin,Eric Hosy,Michel Vivaudou,Frédéric Becq Biochimica et Biophysica Acta:Biomembranes, 2007, 1768 (10), pp.2438-2446. ⟨10.1016/j.bbamem.2007.05.013⟩ Article dans une revue istex hal-00397837v1
Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells C. Norez,F. Antigny,F. Becq,C. Vandebrouck Traffic, 2006, 7, pp.562-573. ⟨10.1111/j.1600-0854.2006.00409.x⟩ Article dans une revue hal-00078138v1
Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells Céline Auzanneau,Caroline Norez,Sabrina Noël,Chantal Jougla,Frédéric Becqet al. Reproduction Nutrition Development, 2006, 46 (3), pp.241-255. ⟨10.1051/rnd:2006013⟩ Article dans une revue hal-04040482v1
Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells Céline Auzanneau,Caroline Norez,Sabrina Noël,Chantal Jougla,Frédéric Becqet al. Reproduction Nutrition Development, 2006, 46 (3), pp.241-255. ⟨10.1051/rnd:2006013⟩ Article dans une revue hal-00900616v1
The Glycine Residues G551 and G1349 within the ATP-Binding Cassette Signature Motifs Play Critical Roles in the Activation and Inhibition of Cystic Fibrosis Transmembrane Conductance Regulator Channels by Phloxine B Patricia Melin,Caroline Norez,Isabelle Callebaut,Frédéric Becq Journal of Membrane Biology, 2006, 208, pp.203-212. ⟨10.1007/s00232-005-7001-0⟩ Article dans une revue istex hal-00113816v1
Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation. Clarisse Vandebrouck,Patricia Melin,Caroline Norez,Renaud Robert,Christelle Guibertet al. Respiratory Research, 2006, 7 (1), pp.113. ⟨10.1186/1465-9921-7-113⟩ Article dans une revue inserm-00097884v1
The cystic fibrosis mutation G1349D within the signature motif LSHGH of NBD2 abolishes the activation of CFTR chloride channels by genistein Patricia Melin,Vincent Thoreau,Caroline Norez,Frédéric Bilan,Alain Kitziset al. Biochemical Pharmacology, 2004, 67 (12), pp.2187-2196. ⟨10.1016/j.bcp.2004.02.022⟩ Article dans une revue istex hal-04564678v1
Synthesis, SAR, Crystal Structure, and Biological Evaluation of Benzoquinoliziniums as Activators of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Channels Cécile Marivingt-Mounir,Caroline Norez,Renaud Dérand,Laurence Bulteau-Pignoux,Dung Nguyen-Huyet al. Journal of Medicinal Chemistry, 2004, 47 (4), pp.962-972. ⟨10.1021/jm0308848⟩ Article dans une revue istex hal-03610137v1
Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Channel by β-Adrenergic Agonists and Vasoactive Intestinal Peptide in Rat Smooth Muscle Cells and Its Role in Vasorelaxation Renaud Robert,Vincent Thoreau,Caroline Norez,Anne Cantereau,Alain Kitziset al. Journal of Biological Chemistry, 2004, 279 (20), pp.21160-21168. ⟨10.1074/jbc.M312199200⟩ Article dans une revue hal-03120019v1
Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity Frédéric Bilan,Vincent Thoreau,Magali Nacfer,Renaud Derand,Caroline Norezet al. Journal of Cell Science, 2004, 117 (10), pp.1923 - 1935. ⟨10.1242/jcs.01070⟩ Article dans une revue hal-03119932v1
General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels. B. Marcet,F. Becq,C. Norez,P. Delmas,Bernard Verrier British Journal of Pharmacology, 2004, 919, pp.919 Article dans une revue hal-00143529v1
A Novel Voltage-dependent Chloride Current Activated by Extracellular Acidic pH in Cultured Rat Sertoli Cells Céline Auzanneau,Vincent Thoreau,Alain Kitzis,Frédéric Becq Journal of Biological Chemistry, 2003, 278 (21), pp.19230-19236. ⟨10.1074/jbc.M301096200⟩ Article dans une revue hal-04564683v1
Cystic fibrosis transmembrane conductance regulator (CFTR) confers glibenclamide sensivity to outwardly rectifying chloride channel (ORCC) in Hi-5 insect cells Marie-Pierre Julien,B. Verrier,M. Cerutti,V. Chappe,M. Golaet al. Journal of Membrane Biology, 1999, 168 (3), pp.229-239. ⟨10.1007/s002329900512⟩ Article dans une revue istex hal-02698653v1
Acute effects of adenosine triphosphates, cyclic 3 ',5 '-adenosine monophosphates, and follicle-stimulating hormone on cytosolic calcium level in cultured immature rat Sertoli cells Nathalie Lalevee,C. Rogier,F. Becq,M. Joffre Biology of Reproduction, 1999, 61 (2), pp.343-352. ⟨10.1095/biolreprod61.2.343⟩ Article dans une revue hal-01619070v1

Communication dans un congrès (2)

Impact of hypoxia in Cystic Fibrosis bronchial epithelial cells: Focus on CFTR and TRPA1 channels Khilian Pascarel,Jenny Colas,Thomas Carrez,Sandra Mirval,Christine Barraultet al. 19es Journées de Recherche Respiratoire (J2R 2023), Groupe RESPIRenT (RESeau de Pneumologie en Innovation et Recherche translaTionnelle) de la Société de pneumologie de langue française (SPLF), Oct 2023, Paris, France. pp.226, ⟨10.1016/j.rmr.2024.01.089⟩ Communication dans un congrès hal-04828420v1
Développement d'un modèle d'infection respiratoire aiguë à Pseudomonas aeruginosa chez le porc Mickaël Riou,Claire C. Chevaleyre,Deborah Brea,Celine Barc,Clarisse Vandebroucket al. 34. Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse (RICAI), Nov 2014, Paris, France Communication dans un congrès hal-02799765v1

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Développement d'un modèle d'infection respiratoire aiguë à Pseudomonas aeruginosa chez le porc Mickaël Riou,Claire C. Chevaleyre,Deborah Brea,Celine Barc,Clarisse Vandebroucket al. 3. Journées d'Animation Scientifique, Jun 2014, Parcay Meslay, France. 2014 Poster de conférence hal-02801096v1

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Toute une histoire... Nadine Pellen,Frédéric Becq 2012, http://www.mucoviscidose-cftr.com/2012/05/28/toute-une-histoire Article de blog scientifique hal-02165663v1

Brevet (7)

Compounds for treating cystic fibrosis Isabelle Callebaut,Jean-Paul Mornon,Jean-Luc Decout,F. Becq,Pierre Lehnet al. France, Patent n° : US10414768B2. 2019 Brevet hal-04768593v1
Utilisation de dérivés des benzo(c)quinoliziniums pour le traitement des pathologies liées aux phénomènes de constriction des cellules musculaires lisses Frédéric Becq,Renaud Robert,Laurence Pignoux,Christian Rogier,Yvette Metteyet al. France, N° de brevet: EP 1 509 520 B1. 2006 Brevet hal-05016386v1
Use of benzo(c)quinolizinium derivatives for the treatment of diseases that are linked to smooth muscle cell constriction Frédéric Becq,Renaud Robert,Laurence Pignoux,Christian Rogier,Yvette Metteyet al. France, Patent n° : US 20050176747A1. 2005 Brevet hal-05016399v1
Utilisation de dérivés de pyrrolo-pyrazines pour la fabrication de médicaments pour le traitement de la mucoviscidose et de la maladies liées a un défaut d'adressage des protéines dans les cellules. F. Becq,L. Meijer,Y. Mettey Patent n° : FR04 10 962. 2004 Brevet hal-00020544v1
Utilisations de la kenpaullone pour une thérapie de la mucoviscidose. F. Becq,L. Meijer,C. Kunick Patent n° : FR04 10961. 2004 Brevet hal-00020546v1
Utilisations de dérivés de purines pour la fabrication de médicaments pour le traitement de la mucoviscidose et de maladies liées a un défaut d'adressage des protéines dans les cellules F. Becq,L. Meijer Patent n° : FR 04 10 958. 2004 Brevet hal-00020556v1
Zwitterion CFTR channel modulators, preparation, pharmaceutical compositions, and therapeuthic use Jean Luc Decout,C. Routaboul,F. Becq,C. Norez Patent n° : FR 2861304, US 20060258612, WO 2005039589. 2003 Brevet hal-00383682v1