Frédéric BIHEL

Publications

Article dans une revue (91)

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010 Perrine Inquimbert,Chantal Fitterer,Sylvain Hugel,Mila Jesic,Yannick Goumonet al. British Journal of Pharmacology, 2026, ⟨10.1111/bph.70285⟩ Article dans une revue hal-05450020v1
Mechanochemical Generation of Active Pd/BippyPhos Catalyst for Efficient C-N Cross-Coupling in Air Deniz Karabiyikli,Alexandre Saad,Sokaina Hammoud,Severine Schneider,Romuald Mancaet al. ChemSusChem, 2025, ⟨10.1002/cssc.202500545⟩ Article dans une revue hal-05090437v1
Fluor NMR study of amino acid derived ligand to study TSPO Luminita Duma,Severine Schneider,Agathe Martinez,Cathy Hachet,Frederic Bihelet al. Biochimie, 2025, 233, pp.14-26. ⟨10.1016/j.biochi.2025.01.015⟩ Article dans une revue hal-05045906v1
Scaffold‐Based Libraries Versus Make‐on‐Demand Space: A Comparative Assessment of Chemical Content Léonard Bui,Teodora Djikic‐stojsic,Guillaume Bret,Frédéric Bihel,Esther Kellenberger ChemMedChem, 2025, 20 (24), ⟨10.1002/cmdc.202500518⟩ Article dans une revue hal-05461615v1
Anti-prion drugs reduce endoplasmic reticulum stress and protect human dopaminergic neurons from death Lucile Gentile,Adeel Nasir,Loane Simon,Anaëlle Timoner,Anaïs Péronet al. Biomedicine and Pharmacotherapy, 2025, 193, pp.118758. ⟨10.1016/j.biopha.2025.118758⟩ Article dans une revue hal-05389104v1
Sustainable Copper-Catalyzed Cyanation of Aryl Iodine through a Design of Experiment Strategy Kevin Brugemann,Moreira Pereira,Philippe Steinsoultz,Clovis Peter,Sokaina Hammoudet al. ACS Sustainable Chemistry & Engineering, 2025, 13 (30), pp.12232-12241. ⟨10.1021/acssuschemeng.5c04898⟩ Article dans une revue hal-05204136v1
Multitarget μ-Opioid Receptor Agonists─Neuropeptide FF Receptor Antagonists Induce Potent Antinociception with Reduced Adverse Side Effects Jolien de Neve,Khadija Elhabazi,Simon Gonzalez,Claire Herby,Séverine Schneideret al. Journal of Medicinal Chemistry, 2024, 67 (9), pp.7603-7619. ⟨10.1021/acs.jmedchem.4c00442⟩ Article dans une revue hal-04631174v1
The IMS Library: from IN‐Stock to Virtual Teodora Djikic‐stojsic,Guillaume Bret,Gaëlle Blond,Nicolas Girard,Clothilde Le Guenet al. ChemMedChem, 2024, 19 (20), pp.e202400381. ⟨10.1002/cmdc.202400381⟩ Article dans une revue hal-04727478v2
Ethaverine and Papaverine Target Cyclin-Dependent Kinase 5 and Inhibit Lung Cancer Cell Proliferation and Migration Arthur Laure,Chloe Royet,Frédéric Bihel,Blandine Baratte,Stéphane Bachet al. ACS Pharmacology & Translational Science, 2024, 7 (5), pp.1377-1385. ⟨10.1021/acsptsci.4c00023⟩ Article dans une revue hal-04609131v1
Synthesis, Characterization, and Self-Assembling Properties of New Amphiphilic Dendrons Bearing Branched TRIS-Derived Oligomers as Polar Head Groups Stéphane Desgranges,Valentin Lacanau,Françoise Bonneté,Marine Soulié,Frédéric Bihelet al. Macromolecules, 2024, 57 (9), pp.4495-4507. ⟨10.1021/acs.macromol.3c02388⟩ Article dans une revue hal-04578834v1
New insights into the regulation of Cystathionine beta synthase (CBS), an enzyme involved in intellectual deficiency in Down syndrome Pierre Conan,Alice Léon,Noéline Caroff,Claire Rollet,Loubna Chaïret al. Frontiers in Neuroscience, 2023, 16, ⟨10.3389/fnins.2022.1110163⟩ Article dans une revue hal-04170617v1
In Situ Formation of Cationic π-Allylpalladium Precatalysts in Alcoholic Solvents: Application to C–N Bond Formation Philippe Steinsoultz,Aurélien Bailly,Patrick Wagner,Estefania Oliva,Martine Schmittet al. ACS Catalysis, 2022, 12 (1), pp.560-567. ⟨10.1021/acscatal.1c04641⟩ Article dans une revue hal-03546107v1
Identification of 8-Hydroxyquinoline Derivatives That Decrease Cystathionine Beta Synthase (CBS) Activity Pierre Conan,Alice Léon,Mathilde Gourdel,Claire Rollet,Loubna Chaïret al. International Journal of Molecular Sciences, 2022, 23 (12), pp.6769. ⟨10.3390/ijms23126769⟩ Article dans une revue hal-03701324v1
Anti-prion Drugs Targeting the Protein Folding Activity of the Ribosome Reduce PABPN1 Aggregation Aline Bamia,Maha Sinane,Rima Naït-Saïdi,Jamila Dhiab,Marc Keruzoréet al. Neurotherapeutics, 2021, 18 (2), pp.1137-1150. ⟨10.1007/s13311-020-00992-6⟩ Article dans une revue hal-03158577v1
Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors Jolien de Neve,Thomas M A Barlow,Dirk Tourwé,Frédéric Bihel,Frédéric Simoninet al. RSC Medicinal Chemistry, 2021, 12 (6), pp.828-870. ⟨10.1039/D1MD00041A⟩ Article dans une revue hal-03435229v1
Identification of an N -acylated- D Arg-Leu-NH 2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia Raphaëlle Quillet,Séverine Schneider,Valérie Utard,Armand Drieu La Rochelle,Khadija Elhabaziet al. Journal of Medicinal Chemistry, 2021, 64 (11), pp.7555-7564. ⟨10.1021/acs.jmedchem.1c00256⟩ Article dans une revue hal-03363456v1
Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model Maud Bollenbach,Simona Nemska,Patrick Wagner,Guillaume Camelin,François Daubeufet al. Molecules, 2021, 26 (2), pp.391. ⟨10.3390/molecules26020391⟩ Article dans une revue hal-03266504v1
Diastereoselective Synthesis of Nonplanar 3-Amino-1,2,4-oxadiazine Scaffold: Structure Revision of Alchornedine Shuang-Qi Tang,Maeva Leloire,Severine Schneider,Julie Mohr,Jacques Bricardet al. Journal of Organic Chemistry, In press, ⟨10.1021/acs.joc.0c01764⟩ Article dans une revue hal-03021041v1
From Electronic Waste to Suzuki−Miyaura Cross‐Coupling Reaction in Water: Direct Valuation of Recycled Palladium in Catalysis Valentin Lacanau,Françoise Bonnete,Patrick Wagner,Martine Schmitt,Daniel Meyeret al. ChemSusChem, 2020, 13 (19), pp.5224-5230. ⟨10.1002/cssc.202001155⟩ Article dans une revue hal-02999762v1
Minimizing HCN in DIC/Oxyma mediated amide bond forming reactions Marion Erny,Marika Lundqvist,Jon Rasmussen,Olivier Ludemann-Hombourger,Frédéric Bihelet al. Organic Process Research and Development, 2020, 24 (7), pp.1341-1349. ⟨10.1021/acs.oprd.0c00227⟩ Article dans une revue hal-02997255v1
POxAP Precatalysts and the Negishi Cross-Coupling Reaction Shuang-Qi Tang,Martine Schmitt,Frédéric Bihel Synthesis: Journal of Synthetic Organic Chemistry, 2019, 52 (01), pp.51-59. ⟨10.1055/s-0039-1690728⟩ Article dans une revue hal-02997250v1
Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model Maud Bollenbach,Claire Lugnier,M Elanie Kremer,Eric Salvat,Salim Megatet al. European Journal of Medicinal Chemistry, 2019, 177, pp.269-290. ⟨10.1016/j.ejmech.2019.05.026⟩ Article dans une revue hal-02322399v1
Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies Amandine Grimm,Imane Lejri,François Hallé,Martine Schmitt,Jürgen Götzet al. Journal of Neuroendocrinology, 2019, ⟨10.1111/jne.12796⟩ Article dans une revue hal-02368671v1
Evolution of coumaroyl conjugate 3‐hydroxylases in land plants: lignin biosynthesis and defense Annette Alber,Hugues Renault,Alexandra Basilio-Lopes,Jean-Etienne Bassard,Zhenhua Liuet al. The Plant Journal, 2019, 99 (5), pp.924-936. ⟨10.1111/tpj.14373⟩ Article dans une revue hal-02437982v1
Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP Shuang-Qi Tang,Jacques Bricard,Martine Schmitt,Frédéric Bihel Organic Letters, 2019, 21 (3), pp.844-848. ⟨10.1021/acs.orglett.9b00031⟩ Article dans une revue hal-02323246v1
TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis Imane Lejri,Amandine Grimm,François Hallé,Mustapha Abarghaz,Christian Kleinet al. Journal of Alzheimer's Disease, In press, pp.1-14. ⟨10.3233/JAD-190127⟩ Article dans une revue hal-02368657v1
A bifunctional-biased mu-opioid agonist–neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects Armand Drieu La Rochelle,Karel Guillemyn,Maria Dumitrascuta,Charlotte Martin,Valérie Utardet al. Pain, 2018, 159 (9), pp.1705-1718. ⟨10.1097/j.pain.0000000000001262⟩ Article dans une revue hal-02368742v1
Human erythrocytes release ATP by a novel pathway involving VDAC oligomerization independent of pannexin-1 Irene Marginedas-Freixa,Cora Lilia Alvarez,Martina Moras,María Florencia Leal Denis,Claude Hattabet al. Scientific Reports, 2018, 8, pp.11384. ⟨10.1038/s41598-018-29885-7⟩ Article dans une revue hal-02368694v1
Aminoguanidine Hydrazone Derivatives as Nonpeptide NPFF1 Receptor Antagonists Reverse Opioid Induced Hyperalgesia Hassan Hammoud,Khadija Elhabazi,Isabelle Bertin,Valeŕie Utard,Emilie Laboureyraset al. ACS Chemical Neuroscience, 2018, 9 (11), pp.2599-2609. ⟨10.1021/acschemneuro.8b00099⟩ Article dans une revue hal-02323065v1
Dioxygenation of styrenes with molecular oxygen in water Shuang-Qi Tang,An-Ping Wang,Martine Schmitt,Frédéric Bihel Tetrahedron Letters, 2018, 59 (15), pp.1465-1468. ⟨10.1016/j.tetlet.2018.03.009⟩ Article dans une revue hal-02326129v1
WNK1 kinase and its partners Akt, SGK1 and NBC-family Na&lt;sup&gt;+&lt;/sup&gt;/HCO3&lt;sup&gt;–&lt;/sup&gt; cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling Wanyin Chen,Leonel Nguekeu Zebaze,Jihu Dong,Laëtitia Chezeau,Perrine Inquimbertet al. Oncotarget, 2018, 9 (43), pp.27197-27219. ⟨10.18632/oncotarget.25509⟩ Article dans une revue hal-02349611v1
Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO Ligands Irene Marginedas-Freixa,Cora L Alvarez,Martina Moras,Claude Hattab,Guillaume Bouyeret al. International Journal of Molecular Sciences, 2018, 19 (10), pp.3098. ⟨10.3390/ijms19103098⟩ Article dans une revue hal-01926983v1
Phenylpyridine-2-ylguanidines and rigid mimetics as novel inhibitors of TNFα overproduction: Beneficial action in models of neuropathic pain and of acute lung inflammation Maud Bollenbach,Eric Salvat,Francois Daubeuf,Patrick Wagner,Ipek Yalcinet al. European Journal of Medicinal Chemistry, 2018, 147, pp.163-182. ⟨10.1016/j.ejmech.2018.01.049⟩ Article dans une revue istex hal-02323729v1
Heteroarylguanidines as Allosteric Modulators of ASIC1a and ASIC3 Channels Omar Alijevic,Hassan Hammoud,Anand Vaithia,Viktor Trendafilov,Maud Bollenbachet al. ACS Chemical Neuroscience, 2018, 9 (6), pp.1357-1365. ⟨10.1021/acschemneuro.7b00529⟩ Article dans une revue hal-02368759v1
Development of a L-Tryptophan-Based Ligand for Regioselective Copper Catalyzed N 2 -Arylation of 1,2,3-Triazoles Alexandra Basilio Lopes,Patrick Wagner,Arthur Eugen Kümmerle,Frédéric Bihel,Jean-Jacques Bourguignonet al. ChemistrySelect, 2017, 2 (22), pp.6544-6548. ⟨10.1002/slct.201701498⟩ Article dans une revue hal-02368798v1
Discovery of Imidazoquinazolinone Derivatives as TSPO Ligands Modulating Neurosteroidogenesis and Cellular Bioenergetics in Neuroblastoma Cells Expressing Amyloid Precursor Protein François Hallé,Imane Lejri,Mustapha Abarghaz,Amandine Grimm,Christian Kleinet al. ChemistrySelect, 2017, 2 (22), pp.6452-6457. ⟨10.1002/slct.201701565⟩ Article dans une revue hal-02368811v1
The translocator protein ligand XBD173 improves clinical symptoms and neuropathological markers in the SJL/J mouse model of multiple sclerosis I. Marginedas-Freixa,C. Hattab,G. Bouyer,F. Halle,A. Cheneet al. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2017, 1863 (12), pp.3016-3027. ⟨10.1016/j.bbadis.2017.09.007⟩ Article dans une revue hal-02290250v1
RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents Khadija Elhabazi,Jean-Paul Humbert,Isabelle Bertin,Raphaelle Quillet,Valérie Utardet al. Neuropsychopharmacology, 2017, 118, pp.188-198. ⟨10.1016/j.neuropharm.2017.03.012⟩ Article dans une revue hal-01603852v1
Efficient and Mild Ullmann-Type N-Arylation of Amides, Carbamates, and Azoles in Water Maud Bollenbach,Pedro Aquino,João Xavier De araújo-Júnior,Jean-Jacques Bourguignon,Frédéric Bihelet al. Chemistry - A European Journal, 2017, 23 (55), pp.13676-13683. ⟨10.1002/chem.201700832⟩ Article dans une revue hal-02368823v1
χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds Olivier van Der Poorten,Robin van den Hauwe,Emilie Eiselt,Cecilia Betti,Karel Guillemynet al. ACS Medicinal Chemistry Letters, 2017, 8 (11), pp.1177-1182. ⟨10.1021/acsmedchemlett.7b00347⟩ Article dans une revue hal-02368778v1
Erratum to: &quot;CMTX1 patients' cells present genomic instability corrected by CamKII inhibitors Saleh Mones,Burkhard Gess,Benoit Bordignon,Alexandre Altie,Peter Younget al. Orphanet Journal of Rare Diseases, 2016, 11, ⟨10.1186/s13023-015-0354-2⟩ Article dans une revue hal-02630248v1
The effect of neuropeptide FF in the amygdala kindling model I. Buffel,A. Meurs,J. Portelli,R. Raedt,V. de Herdtet al. Acta Neurologica Scandinavica Supplementum, 2016, 134 (3), pp.181-188. ⟨10.1111/ane.12526⟩ Article dans une revue istex hal-02368848v1
Opioid adjuvant strategy: improving opioid effectiveness Frédéric Bihel Future Medicinal Chemistry, 2016, 8 (3), pp.339-354. ⟨10.4155/fmc.15.186⟩ Article dans une revue hal-02368859v1
Synthesis of 3-amino-3,4-dihydro-1H-quinolin-2-ones through regioselective palladium-catalyzed intramolecular cyclization François Hallé,Olivier van Der Poorten,Christelle Doebelin,Marie Niederst,Séverine Schneideret al. Tetrahedron Letters, 2016, 57 (14), pp.1547-1550. ⟨10.1016/j.tetlet.2016.02.094⟩ Article dans une revue istex hal-02290245v1
TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood I Marginedas-Freixa,C Hattab,G Bouyer,F Halle,A Cheneet al. Scientific Reports, 2016, 6, pp.33516 ⟨10.1038/srep33516⟩ Article dans une revue hal-01369499v1
RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions Raphaelle Quillet,Safia Ayachi,Frédéric Bihel,Khadija Elhabazi,Brigitte Ilienet al. Alimentary Pharmacology & Therapeutics, 2016, 160, pp.84-132. ⟨10.1016/j.pharmthera.2016.02.005⟩ Article dans une revue hal-02368835v1
Development of Dipeptidic hGPR54 Agonists Christelle Doebelin,Isabelle Bertin,Séverine Schneider,Martine Schmitt,Jean-Jacques Bourguignonet al. ChemMedChem, 2016, 11 (19), pp.2147-2154. ⟨10.1002/cmdc.201600331⟩ Article dans une revue istex hal-02368845v1
CMTX Disorder and CamKinase Frédéric Bihel,Burkhard Gess,Michel Fontés Frontiers in Cellular Neuroscience, 2016, 10, pp.1-4. ⟨10.3389/fncel.2016.00049⟩ Article dans une revue hal-02630284v1
d -Glucose: An Efficient Reducing Agent for a Copper(II)-Mediated Arylation of Primary Amines in Water Maud Bollenbach,Patrick Wagner,Pedro Aquino,Jean-Jacques Bourguignon,Frédéric Bihelet al. ChemSusChem, 2016, 9 (22), pp.3244-3249. ⟨10.1002/cssc.201600801⟩ Article dans une revue istex hal-02368856v1
TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood I Marginedas-Freixa,C Hattab,G Bouyer,F Halle,A Cheneet al. Scientific Reports, 2016, 6, ⟨10.1038/srep33516⟩ Article dans une revue hal-05431604v1
Development of a Peptidomimetic Antagonist of Neuropeptide FF Receptors for the Prevention of Opioid-Induced Hyperalgesia Frédéric Bihel,Jean-Paul Humbert,Severine Schneider,Isabelle Bertin,Patrick Wagneret al. ACS Chemical Neuroscience, 2015, 6 (3), pp.438-445. ⟨10.1021/cn500219h⟩ Article dans une revue hal-03198603v1
Rapid and scalable synthesis of innovative unnatural α,β or γ-amino acids functionalized with tertiary amines on their side-chains Séverine Schneider,Hussein Ftouni,Songlin Niu,Martine Schmitt,Frédéric Simoninet al. Organic & Biomolecular Chemistry, 2015, 13 (25), pp.7020-7026. ⟨10.1039/c5ob00828j⟩ Article dans une revue hal-04720697v1
Neuropeptide FF receptors as novel targets for limbic seizure attenuation Jeanelle Portelli,Alfred Meurs,Frederic Bihel,Hassan Hammoud,Martine Schmittet al. Neuropharmacology, 2015, 95, pp.415-423. ⟨10.1016/j.neuropharm.2015.04.030⟩ Article dans une revue istex hal-03005155v1
Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103 Laurent Rouméas,Jean-Paul Humbert,Séverine Schneider,Christelle Doebelin,Isabelle Bertinet al. Peptides, 2015, 71, pp.156-161. ⟨10.1016/j.peptides.2015.07.016⟩ Article dans une revue istex hal-02997151v1
Design and validation of a homogeneous time-resolved fluorescence cell-based assay targeting the ligand-gated ion channel 5-HT3A Emilie Blanc,Patrick Wagner,Fabrice Plaisier,M. Schmitt,Thierry Durrouxet al. Analytical Biochemistry, 2015, 484, pp.105-12. ⟨10.1016/j.ab.2015.03.035⟩ Article dans une revue istex hal-02064366v1
A Yeast/Drosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency Alexandra Seguin,Véronique Monnier,Amandine Palandri,Frédéric Bihel,Michael Reraet al. Oxidative Medicine and Cellular Longevity, 2015, 2015, pp.565140. ⟨10.1155/2015/565140⟩ Article dans une revue hal-01267591v1
CMTX1 patients' cells present genomic instability corrected by CamKII inhibitors Saleh Mones,Burkhardt Gess,Benoit Bordignon,Alexandre Altie,Peter Younget al. Orphanet Journal of Rare Diseases, 2015, 10, ⟨10.1186/s13023-015-0270-5⟩ Article dans une revue hal-02634560v1
The long‐lasting love affair between the budding yeast Saccharomyces cerevisiae and the Epstein‐Barr virus María José Lista,Cécile Voisset,Marie‐astrid Contesse,Gaëlle Friocourt,Chrysoula Daskalogianniet al. Biotechnology Journal, 2015, 10 (11), pp.1670-1681. ⟨10.1002/biot.201500161⟩ Article dans une revue istex hal-05596376v1
Neuropeptide FF and prolactin-releasing peptide decrease cortical excitability through activation of NPFF receptors. Ine Buffel,Alfred Meurs,Jeanelle Portelli,Robrecht Raedt,Veerle de Herdtet al. Epilepsia, 2015, 56 (3), pp.489-498. ⟨10.1111/epi.12928⟩ Article dans une revue hal-03005167v1
CamKII inhibitors reduce mitotic instability, connexon anomalies and progression of the &lt;em&gt;in vivo&lt;/em&gt; behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene Saleh Mones,Benoit Bordignon,Franck Peiretti,Jean-Francois Landrier,Burkhardt Gesset al. Frontiers in Neuroscience, 2014, 8, 10 p. ⟨10.3389/fnins.2014.00151⟩ Article dans une revue hal-02639042v1
Structure-activity relationship study around guanabenz identifies two derivatives retaining antiprion activity but having lost alpha 2-adrenergic receptor agonistic activity - Phu Hai Nguyen,Hassan Hammoud,Sophie Halliez,Yanhong Pang,Justine Evrardet al. ACS Chemical Neuroscience, 2014, 5 (10), pp.1075-1082. ⟨10.1021/cn5001588⟩ Article dans une revue hal-02635473v1
Fully regiocontrolled polyarylation of pyridine Christelle Doebelin,Patrick Wagner,Frédéric Bihel,Nicolas Humbert,Cyril Assongo Kenfacket al. Journal of Organic Chemistry, 2014, 79 (3), pp.908-918. ⟨10.1021/jo402200q⟩ Article dans une revue hal-01065061v1
The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction. Christian Klein,Christine Mensah-Nyagan,Omar Taleb,Jean-Jacques Bourguignon,Martine Schmittet al. Neuropharmacology, 2013, 70, pp.254-260. ⟨10.1016/j.neuropharm.2013.02.006⟩ Article dans une revue istex hal-02612146v1
Trisubstitution of pyridine through sequential and regioselective palladium cross-coupling reactions affording analogs of known GPR54 antagonists Christelle Doebelin,Patrick Wagner,Isabelle Bertin,Frederic Simonin,Martine Schmittet al. RSC Advances, 2013, 3 (26), pp.10296. ⟨10.1039/c3ra41985a⟩ Article dans une revue hal-03005205v1
Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors Khadija Elhabazi,Jean-Paul Humbert,Isabelle Bertin,Martine Schmitt,Frédéric Bihelet al. Neuropharmacology, 2013, 75, pp.164-171. ⟨10.1016/j.neuropharm.2013.07.012⟩ Article dans une revue istex hal-02650252v1
Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors Ronan Gealageas,Severine Schneider,Jean-Paul Humbert,Isabelle Bertin,Martine Schmittet al. Bioorganic and Medicinal Chemistry Letters, 2012, 22 (24), pp.7471-7474. ⟨10.1016/j.bmcl.2012.10.049⟩ Article dans une revue istex hal-02993696v1
New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam. F.J.J. Bihel,Hélène Justiniano,Martine Schmitt,Malik Hellal,Mohamed A. Ibrahimet al. Bioorganic and Medicinal Chemistry Letters, 2011, 21, pp.6567-6572 Article dans une revue hal-00667395v1
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments Khadija Elhabazi,J Trigo,C Mollereau,L Mouledous,J.-M. Zajacet al. British Journal of Pharmacology, 2011, 165 (2), pp.424-435. ⟨10.1111/j.1476-5381.2011.01563.x⟩ Article dans une revue hal-04674971v1
6-Endo-dig cyclization of heteroarylesters to alkynes promoted by Lewis acid catalyst in the presence of Bronsted acid Hellal Malik,Bourguignon Jean-Jacques,Frédéric Bihel Tetrahedron Letters, 2008, 49 (1), pp.62-65 Article dans une revue hal-00195333v1
Synthesis and reactivity of 2,3-dihydro-1H-2,3-benzodiazepine-1,4(5H)-dione Frédéric Bihel,Hellal Malik,Bourguignon Jean-Jacques Synthesis: Journal of Synthetic Organic Chemistry, 2007, 24, pp.3791-3796 Article dans une revue hal-00195328v1
Microwave-assisted cyclic amidine synthesis using TiCl4. M. Hellal,F. Bihel,A. Mongeot,J.-J. Bourguignon Organic & Biomolecular Chemistry, 2006, 4, pp.3142-3146 Article dans une revue hal-00129884v1
substituded thiazolamide coupled to a redox delivery system : a new gamma-secretase inhibitor with enhanced pharmacokinetic profile Y. Younes,G. Quelever,C. Garino,N. Pietrancosta,M. Shelaet al. Organic & Biomolecular Chemistry, 2005, 21, pp.612-8 Article dans une revue hal-00159607v1
Substituted thiazolamide coupled to a redox delivery system: a new γ-secretase inhibitor with enhanced pharmacokinetic profile Younes Laras,Gilles Quéléver,Cédrik Garino,Nicolas Pietrancosta,Mahmoud Shehaet al. Organic & Biomolecular Chemistry, 2005, 3 (4), pp.612-618. ⟨10.1039/b415090b⟩ Article dans une revue istex hal-02351730v1
New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties C. Garino,F. Bihel,N. Pietrancosta,Y. Laras,G. Queleveret al. Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.135-138 Article dans une revue hal-00117234v1
Photoactivatable helical peptide inhibitors of y-secretase covalently bind to presenilin at a site close to but distinct from the active site. A.Y. Kornilova,F. Bihel,C. Das,M.S. Wolfe Proceedings of the National Academy of Sciences of the United States of America, 2005, 102, pp.3230-5 Article dans une revue hal-00159650v1
Substituted thiazolamide coupled to a redox delivery system: a new gamma-secretase inhibitor with enhanced pharmacokinetic profile Y. Laras,G. Quelever,C. Garino,N. Pietrancosta,M. Shehaet al. Organic & Biomolecular Chemistry, 2005, 3, pp.612-618 Article dans une revue hal-00118749v1
New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties Cédrik Garino,Frédéric Bihel,Nicolas Pietrancosta,Younes Laras,Gilles Quéléveret al. Bioorganic and Medicinal Chemistry Letters, 2005, 15 (1), pp.135-138. ⟨10.1016/j.bmcl.2004.10.018⟩ Article dans une revue istex hal-02351737v1
N-acyl substituted 7-amino-4-chloroisocoumarin: a peptide degradation model via an imide mechanism C. Garino,F. Bihel,F. Souard,G. Quelever,J.L. Kraus Bioorganic and Medicinal Chemistry Letters, 2004, 14, pp.1771-1774 Article dans une revue hal-00305873v1
Novel synthesis of 3,4-dihydro-5-bromo[1,4]oxazin-2-one derivatives, new protease inhibitor scaffold F. Bihel,J.L. Kraus Organic & Biomolecular Chemistry, 2003, 1, pp.793-799 Article dans une revue hal-00304322v1
New b-strand macrocyclic peptidomimetic analogues containing alpha-(O-, S- or NH-)aryl substituted glycine residues: synthesis, chemical and enzymatic properties Gilles Quéléver,Frédéric Bihel,Jean-Louis Kraus Organic & Biomolecular Chemistry, 2003, 1, pp.1676-1683 Article dans une revue hal-00154124v1
Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new β-amyloid peptide production inhibitors and their activities on various classes of protease Agnès Petit-Paitel,Frédéric Bihel,Gilles Quéléver,Hugues Lelouard,Agnès Petitet al. Bioorganic and Medicinal Chemistry, 2003, 11 (14), pp.3141-3152. ⟨10.1016/s0968-0896(03)00235-9⟩ Article dans une revue istex hal-03016636v1
Novel synthesis of 3,4-dihydro-5-bromo[1,4]oxazin-2-one derivatives, new protease inhibitor scaffold Frédéric Bihel,Jean-Louis Kraus Organic & Biomolecular Chemistry, 2003, 1, pp.793-799 Article dans une revue hal-00154126v1
New beta-strand macrocyclic peptidomimetic analogues containing alpha-(O-, S- or NH-)aryl substituted glycine residues: synthesis, chemical and enzymatic properties G. Quelever,F. Bihel,J.L. Kraus Organic & Biomolecular Chemistry, 2003, 1, pp.1676-83 Article dans une revue hal-00304318v1
Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease F. Bihel,G. Quelever,H. Lelouard,A. Petit,C. Alves da Costaet al. Bioorganic and Medicinal Chemistry, 2003, 11, pp.3141-3152 Article dans une revue hal-00304333v1
Reactivity studies of 3-alkoxy-7-amino-4-chloroisocoumarins (beta-amyloid peptide inhibitors) versus different classes of amines F. Bihel,R. Faure,J.L. Kraus Organic & Biomolecular Chemistry, 2003, 1, pp.800-802 Article dans une revue hal-00304324v1
Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new b-amyloid peptide production inhibitors and their activities on various classes of protease Frédéric Bihel,Gilles Quéléver,Hugues Lelouard,Agnes Petit,Christine Alves da Costaet al. Bioorganic and Medicinal Chemistry, 2003, 11, pp.3141-3152 Article dans une revue hal-00154122v1
Synthesis and antiviral activity of new Anti-HIV amprenavir bioisosteres Luc Rocheblave,Frédéric Bihel,Céline de Michelis,Ghislaine Priem,Jérôme Courcambecket al. Journal of Medicinal Chemistry, 2002, 45, pp.3321-3324 Article dans une revue hal-00154120v1
Synthesis and antiviral activity of new anti-HIV amprenavir bioisosteres L. Rocheblave,F. Bihel,C. de Michelis,G. Priem,J. Courcambecket al. Journal of Medicinal Chemistry, 2002, 45, pp.3321-24 Article dans une revue hal-00304305v1
New 3'-azido-3'-deoxythymidin-5'-yl O-(omega-hydroxyalkyl) carbonate prodrugs: Synthesis and anti-HIV evaluation. Patrick Vlieghe,Frédéric Bihel,Thierry Clerc,Christophe Pannecouque,Myriam Witvrouwet al. Journal of Medicinal Chemistry, 2001, 44, pp.777-786 Article dans une revue hal-00154110v1
New protease inhibitors prevent gamma-secretase-mediated production of Ab40/42 without affecting Notch cleavage. Frédéric Bihel,Agnes Petit,Christine Alves da Costa,Olivier Pourquié,Frédéric Checleret al. Nature Cell Biology, 2001, 3, pp.507-511 Article dans une revue hal-00154118v1
Design of potential newHIV protease inhibitors: enantioconvergent synthesis of new pyrrolidin-3-ol, and pyrrolidin-3-one peptide conjugates. Frédéric Bihel,Jérôme Courcambeck,Céline de Michelis,Gilles Quéléver,Jean-Louis Kraus Journal of the Chemical Society Perkin Transactions 1, 2001, pp.1421-1430 Article dans une revue hal-00154116v1

Communication dans un congrès (12)

Anti-Prion drugs reduce endoplasmic reticulum stress and protect human dopaminergic neurons from death Cécile Voisset,Lucile Gentile,Adeel Nasir,Loane Simon,Anaëlle Timoneret al. Prion 2025, Nov 2025, Rio de Janero, Brazil. ⟨10.3389/978-2-8325-6563-6⟩ Communication dans un congrès hal-05596509v1
Anti-tumor activity of new ligands targeting LINGO1- a protein primarily expressed in CNS for the treatment of glioblastomas Wanyin Chen,Anthony Guillemain,Lauren Blot,Fabienne Fasani,Esther Kellenbergeret al. Colloque Niche et épigénétique des tumeurs, Jul 2020, Online, France Communication dans un congrès hal-03686680v1
Allosteric Modulators of CDK4 for Lung Cancer Therapeutics May Catherine Morris,Frédéric Bihel,Sebastien Diot,Clovis Peter,Céline Bouclieret al. Annual Meeting on Experimental Biology, The Federation of American Societies for Experimental Biology (FASEB), Apr 2020, San Diego (California), United States. pp.1-1, ⟨10.1096/fasebj.2020.34.s1.00334⟩ Communication dans un congrès hal-04570635v1
The research of new therapeutic targets and small chemical molecules for glioblastoma therapies W. Chen,A. Guillemain,L. Blot,Fabienne Fasani,E. Kellenbergeret al. Central South University in HuNan, Dec 2019, Changsha, China Communication dans un congrès hal-03686683v1
6-Endo-dig cyclization of heteroarylesters to alkynes promoted by Lewis acid catalyst in presence of Brønsted acid Frédéric Bihel,Hellal Malik,Bourguignon Jean-Jacques XXVII REGIO, Sep 2007, Buhl, France Communication dans un congrès hal-00195398v1
6-Endo-dig cyclization of heteroarylesters to alkynes promoted by Lewis acid catalyst in presence of Brønsted acid Hellal Malik,Bourguignon Jean-Jacques,Frédéric Bihel SAJEC, Oct 2007, Paris, France Communication dans un congrès hal-00195387v1
Synthèse et fonctionnalisation de 2,3-benzodiazépines : Vers la construction d'une chimiothèque focalisée Hellal Malik,Frédéric Bihel,Bourguignon Jean-Jacques Journée Scientifique de l'Institut Gilbert Laustriat, Apr 2007, Illkirch, France Communication dans un congrès hal-00195391v1
Creation of a Chemical Diversity Space Around the 2,3-Benzodiazepine Scaffold Frédéric Bihel,Hellal Malik,Bourguignon Jean-Jacques International Symposium on Advances in Synthetic and Medicinal Chemistry, Aug 2007, Saint Petersbourg, Russia Communication dans un congrès hal-00195383v1
Microwave-assisted cyclic amidine synthesis using TiCl4 Hellal Malik,Frédéric Bihel,Bourguignon Jean-Jacques Journée Scientifique de l'IFR Gilbert Laustriat, 2006, Illkirch, France Communication dans un congrès hal-00195376v1
Design and synthesis of Benzodiazepines as phthalazine structurally-related compounds Hellal Malik,Frédéric Bihel,Bourguignon Jean-Jacques 10th International Symposium on the Chemistry and Pharmacology of Pyridazines, Jun 2006, Strasbourg, France Communication dans un congrès hal-00195377v1
Synthèse assistée par micro-onde d'amidines cycliques médiée par TiCl4 Hellal Malik,Frédéric Bihel,Bourguignon Jean-Jacques SECO'43, May 2006, Fréjus, France Communication dans un congrès hal-00195388v1
P2Y1 Purinergic Receptor : Synthesis of a fluorescent Probe Frédéric Bihel Strep GPCR / Joint Meeting, Feb 2005, Barcelone, Spain Communication dans un congrès hal-00195392v1

Poster de conférence (18)

19F NMR study of the interaction between an amino acid derived ligand and the transmembrane protein TSPO Luminita Duma,Severine Schneider,Agathe Martinez,Cathy Hachet,Frédéric Bihelet al. XIVth International conference, NMR: a tool for biology, May 2025, Paris, France Poster de conférence hal-05105181v1
Evaluation of the anti-tumoral acitivty of new ligands targeting LINGO-1 for the treatment of glioblastoma W. Chen,A. Guillemain,L. Blot,F. Fasani,E. Kellenbergeret al. Journée du cancéropole Grand ouest, Oct 2020, Virtual, France Poster de conférence hal-03686678v1
Anti-tumor activity of new ligands targeting LINGO1- a protein primarily expressed in CNS for the treatment of glioblastomas Wanyin Chen,Anthony Guillemain,Lauren Blot,Fabienne Fasani,Esther Kellenbergeret al. Colloque Niche et épigénétique des tumeurs, Jul 2020, Online, France. Poster de conférence hal-03686675v1
Etude de l’activité anti-tumorale de nouveaux ligands ciblant LINGO-1 pour le traitement des glioblastomes Wanyin Chen,Anthony Guillemain,Lauren Blot,Fabienne Fasani,Esther Kellenbergeret al. Colloque de l’ADOC, Jul 2019, Orléans, France Poster de conférence hal-03686230v1
Nouvelles molécules chimiques anti-tumorales pour le traitement du glioblastomes W. Chen,A. Guillemain,L. Blot,F. Fasani,E. Kellenbergeret al. 13es journées du Cancéropôle Grand Ouest, Jul 2019, Tours, France Poster de conférence hal-02973622v1
Etude de l’activité anti-tumorale de nouveaux ligands ciblant LINGO-1 pour le traitement des glioblastomes Wanyin Chen,Anthony Guillemain,Lauren Blot,Fabienne Fasani,Esther Kellenbergeret al. Journée Fédération FR2708 Physique et Chimie du Vivant, Apr 2019, Orléans, France Poster de conférence hal-03625295v1
Anti-tumoral activity of new ligands targeting LINGO-1 for the treatment of glioblastoma Wanyin Chen,Anthony Guillemain,Laurent Blot,Fabienne Fasani,E. Kellenbergeret al. 1st meeting « Niches and Epigenetic of tumors », Mar 2019, Nantes, France Poster de conférence hal-02973567v1
In vitro and in vivo characterization of RF313 the first orally available NPFF receptor antagonist. Frédéric Simonin,J-P Humbert,I Bertin,Raphaelle Quillet,Valérie Utardet al. SFN 45th Annual Meeting, Chicago, USA, (2015-10-17 / 2015-10-21), Oct 2015, Chicago, United States. 2015 Poster de conférence hal-04747309v1
Pharmacological characterization of NPFF1R/GPR147 antagonists for the study of its role in the central control of reproduction Raphaelle Quillet,V Utard,F Bihel,M Schmitt,J-J Bourguignonet al. Journées du Campus d’Illkirch, Apr 2015, Illkirch, France. 2015 Poster de conférence hal-05037265v1
Pallado-catalyzed reactions applied to solid phase synthesis of dipeptidic GPR54 agonists Christelle Doebelin,I Bertin,M Schmitt,Frédéric Simonin,Valérie Simonneauxet al. 18e Congrès du GFPP, Sète, France, (2013-05-26 / 2013-05-31), May 2013, Sète, France. 2013 Poster de conférence hal-04747272v1
Modulation of nociception and morphine analgesia by endogenous RF−amide peptides. Frédéric Simonin,J-P Humbert,I Bertin,M Schmitt,Frédéric Bihelet al. Gordon Research Conference on Molecular Pharmacology, Il Ciocco, Italie (2013-05-08 / 2013-05-13), May 2013, Il Ciocco, Italy. 2013 Poster de conférence hal-04750860v1
Neuropeptide FF receptors as novel drug targets in epilepsy I Smolders,J Portelli,Frédéric Bihel,M Schmitt,J Coppenset al. SFN 42nd Annual Meeting, New Orleans, USA, (2012-10-13 / 2012-10-17), Oct 2012, New Orleans, United States. 2012 Poster de conférence hal-04747273v1
Development of the first orally available NPFF1-R antagonist capable of reversing opioid-induced hyperalgesia in rodents Frédéric Bihel,S Schneider,M Schmitt,J-P Humbert,Khadija Elhabaziet al. International conference on Medicinal Chemistry RICT 2012, Poitiers, France, (2012-07-04 /2012-07-06), Jul 2012, Poitiers, France. 2012 Poster de conférence hal-04754574v1
Polysubstituted derivatives of pyridines as heterocyclic ligands of GPR54 C Doebelin,P Wagner,M Messe,M Schmitt,F Bihelet al. Journée Campus Illkirch, ESBS, Illkirch, France, (2012-04-02 / 2012-04-03), Apr 2012, Illkirch, France. 2012 Poster de conférence hal-04749163v1
Neuropeptide FF decreases Cortical and Amygdala Excitability Via NPFF1 and/or NPFF2 Receptors A Meurs,I Buffel,J Portelli,R Raedt,L Sionckeet al. SFN 42nd Annual Meeting, New Orleans, USA, (2012-10-13 / 2012-10-17), Oct 2012, New Orleans, United States. 2012 Poster de conférence hal-04747286v1
Regioselective Pd-catalyzed synthesis of polyfunctionalyzed pyridines as GPR54 antagonists. C Doebelin,P Wagner,M Messe,M Schmitt,F Bihelet al. International conference on Medicinal Chemistry RICT 2012, Jul 2012, Poitiers, France. 2012 Poster de conférence hal-05037266v1
Synthesis and SAR analysis of aminoguanidines hydrazones, a series of non peptidic NPFF ligands M Schmitt,H Hammoud,F Bihel,J-P Humbert,I Bertinet al. International conference on Medicinal Chemistry RICT 2012, Jul 2012, Poitiers, France. 2012 Poster de conférence hal-05037289v1
Dérivés polysubstitués de pyridines comme ligands hétérocycliques de GPR54 Christelle Doebelin,P Wagner,M Messe,M Schmitt,Frédéric Bihelet al. Journée jeunes chercheurs SCT, Mar 2012, Romainville, France. 2012 Poster de conférence hal-05035740v1

Brevet (4)

FORMULATIONS FOR METAL CATALYSIS IN WATER COMPRISING A SURFACTANT AND A LIPOPHILIC COMPOUND Frédéric Bihel,Damien Bourgeois,Christine Contino-Pepin,Stéphane Desgranges,Valentin Lacanau United States, Patent n° : US2023191383. 2023 Brevet hal-04930599v1
NOVEL PFAR-INHIBITING COMPOUNDS Martine Simonelig,Frédéric Bihel,Cécile Voisset,Capucine Trollet France, Patent n° : 20220273637. 2022 Brevet hal-04012493v1
Utilisation de tensioactifs pour extraire de l'or ou un métal du groupe platine à partir de compositions organiques Damien Bourgeois,Daniel Meyer,F. Bihel,Christine Contino-Pepin,Schmitt M.et al. France, N° de brevet: EP16180529. 2016 Brevet hal-02120430v1
Ornithine- and lysine-derivatives for the treatment of pain Jean-Jacques Bourguignon,Frédéric Bihel,Martine Schmitt,Frédéric Simonin,Guy Simmonetet al. France, Patent n° : EP2669276. 2013 Brevet hal-04742565v1