Frédéric Leroux

Présentation

Frederic Leroux obtained a PhD in chemistry at the University of Konstanz (Germany), under the supervision of Prof. H. Fischer. In 1998, he moved to a postdoctoral position with Prof. M. Schlosser at the University of Lausanne (Switzerland) and accepted the same year a position of Assistant Professor. In 2001 he moved then to the Swiss Federal Institute of Technology in Lausanne (EPFL). He started his independent research career in 2003 as CNRS Research Associate at the University of Strasbourg (France). He obtained his habilitation in 2005 and was promoted CNRS Research Director in 2009.

Frederic Leroux is presently the director of the molecular chemistry department “Laboratoire d’Innovation Moléculaire et Applications” UMR CNRS 7042-LIMA of the Université de Strasbourg, Université de Haute-Alsace and the CNRS (lima.unistra.fr) and director of the joint CNRS-Bayer-Université de Strasbourg laboratory on organofluorine chemistry.

His research (coha.unistra.fr) is published in &gt;120 peer-reviewed publications, 18 patents, 11 books and book chapters and presented by invitation at &gt;80 (inter)national conferences. He is Fellow of the Royal Society of Chemistry (FRSC) and member of the European Academy of Sciences and Arts. He is also a member of the International Scientific Committee of the Moissan Prize (Fluorine Chemistry), Director of the French Fluorine Network (http://www.reseau-fluor.fr) and President of the French-Japanese Society of Medicinal and Fine Chemistry (fjs.crihan.fr).

The philosophy of his research is based on a fruitful interplay of several objectives (a) the synthesis of biologically relevant molecules, (b) asymmetric methodologies using organic and organometallic chemistry, (c) organofluorine chemistry and (d) application of the objectives to industrial problems, which led to strong industrial collaborations. The discovery of new and mild methodologies to introduce fluorine atoms or emergent fluorinated groups (OCF3, CHF2, ...) onto heterocycles as well as their stereoselective introduction onto Csp3-centers is a key topic of his research and developed in close collaboration with industry.

Publications

Article dans une revue (133)

Direct Fluoroformylation of the C3 ‐Position of Indoles with 2,4‐Dinitro(trifluoromethoxy)benzene as Fluorocarbonyl Source Lilian Wisson,Gilles Hanquet,Fabien Toulgoat,Thierry Billard,Frédéric R Lerouxet al. ChemistryOpen, 2026, 15 (3), pp.e202500563. ⟨10.1002/open.202500563⟩ Article dans une revue hal-05549792v1
Double Functionalization of Atropisomeric Biphenyl Sulfoxides by Ortho ‐Metalation and DYKAT Toward Chiral Quaterphenyl‐Based Borane Lewis Acids Jordan Berreur,Julien Bortoluzzi,Laura Köring,Frédéric R Leroux,Jan Paradieset al. European Journal of Inorganic Chemistry, 2026, pp.e70158. ⟨10.1002/ejic.70158⟩ Article dans une revue hal-05567495v1
Synthesis of Aryl Difluoroalkyl Ethers by Deprotonative Functionalization of the Difluoromethoxy (–OCHF2) Moiety Guillaume Siegel,Anaïs Loison,Gilles Hanquet,Frédéric R Leroux,Armen Panossian European Journal of Organic Chemistry, 2025, 29 (3), pp.e202500852. ⟨10.1002/ejoc.202500852⟩ Article dans une revue hal-05549783v1
Intertwined Processes in the Pummerer‐Type Rearrangement Affording α‐Trifluoromethoxylated Thioethers and the Corresponding Highly Enantioenriched Sulfoxides Nicolas Moget,Jérémy Saiter,Fabien Toulgoat,Thierry Billard,Frédéric R. Lerouxet al. Chemistry - A European Journal, 2025, 31 (72), pp.e02465. ⟨10.1002/chem.202502465⟩ Article dans une revue hal-05549752v1
Trifluoromethoxylation of Arynes using 2,4‐Dinitro‐1‐(trifluoromethoxybenzene) as Trifluoromethoxide Anion Source Lilian Wisson,Gilles Hanquet,Fabien Toulgoat,Thierry Billard,Armen Panossianet al. European Journal of Organic Chemistry, In press, 27 (28), pp.e202400388. ⟨10.1002/ejoc.202400388⟩ Article dans une revue hal-04591124v1
3‐Amido‐benzo[b]silines: straightforward modular 2‐step synthesis and photophysical properties Stéphane Golling,Tiahong Yan,Valérie Mazan,Frederic R. Leroux,Ilaria Ciofiniet al. Advanced Synthesis and Catalysis, In press, ⟨10.1002/adsc.202400293⟩ Article dans une revue hal-04538289v1
Direct Introduction of the 1‐Fluorocyclopropyl Group &lt;i&gt;via&lt;/i&gt; Stille Cross‐Coupling – A Way of Getting Around Per‐ and Polyfluoroalkyl Substances (PFASs) Florian Audet,Morgan Donnard,Armen Panossian,Philipp M Holstein,David Bernieret al. Advanced Synthesis and Catalysis, 2024, ⟨10.1002/adsc.202400401⟩ Article dans une revue hal-04655162v1
Phenylseleno trifluoromethoxylation of alkenes Clément Delobel,Armen Panossian,Gilles Hanquet,Frédéric R Leroux,Fabien Toulgoatet al. Beilstein Journal of Organic Chemistry, 2024, 20, pp.2434-2441. ⟨10.3762/bjoc.20.207⟩ Article dans une revue hal-04711420v1
Unlocking the Power of Acyl Fluorides: A Comprehensive Guide to Synthesis and Properties Clémence Bonnefoy,Adrien Gallego,Clément Delobel,Betty Raynal,Maxime Decourtet al. European Journal of Organic Chemistry, 2024, 27 (18), pp.e202400142. ⟨10.1002/ejoc.202400142⟩ Article dans une revue hal-04591439v1
Synthesis of 2-amidoindenone derivatives through an ynamide carbosilylation / Houben-Hoesch cyclization 2-step sequence Pierre Hansjacob,Célia Schwoerer,Frédéric R Leroux,Morgan Donnard Organic & Biomolecular Chemistry, 2024, 22, pp.70-73. ⟨10.1039/D3OB01787G⟩ Article dans une revue hal-04316905v1
Synthesis of Polyfluoroalkyl Aryl Ethers Mediated by Sulfuryl Fluoride as a Traceless Activator Clotilde Plaçais,Lilian Wisson,Isabelle Chataigner,Morgan Donnard,Armen Panossianet al. Organic Letters, 2024, 26 (46), pp.10046-10050. ⟨10.1021/acs.orglett.4c03989⟩ Article dans une revue hal-04804896v1
On a seamlessly replicable circular photoreactor for lab-scale continuous flow applications Yi-Hsuan Tsai,Martin Cattoen,Guillaume Masson,Gabrielle Christen,Lisa Traberet al. Reaction Chemistry & Engineering, In press, ⟨10.1039/D4RE00109E⟩ Article dans une revue hal-04558234v1
(NHC-olefin)-nickel(0) nanoparticles as catalysts for the (Z)-selective semi-hydrogenation of alkynes and ynamides Marta G. Avello,Stéphane Golling,Lai Truong-Phuoc,Loic Vidal,Thierry Romeroet al. Chemical Communications, 2023, 59, pp.1537. ⟨10.1039/D2CC05302K⟩ Article dans une revue hal-03909675v2
Comprehensive Study and Development of a Metal-Free and Mild Nucleophilic Trifluoromethoxylation Clémence Bonnefoy,Armen Panossian,Gilles Hanquet,Frédéric Leroux,Fabien Toulgoatet al. Chemistry - A European Journal, 2023, 29 (46), ⟨10.1002/chem.202301513⟩ Article dans une revue hal-04165325v1
Zinc-Catalyzed Hydrocyanation of Ynamides and Photoisomerization, a General and Selective Access to E and Z Trisubstituted Alpha-Enamidonitriles Pierre Hansjacob,Frédéric R Leroux,Morgan Donnard Chemistry - A European Journal, 2023, pp.e202300120. ⟨10.1002/chem.202300120⟩ Article dans une revue hal-04051662v1
Ruthenium‐catalyzed Synthesis of Aryl and Alkenyl Halides from Fluorosulfonates Clotilde Plaçais,Sherif J. Kaldas,Morgan Donnard,Armen Panossian,David Bernieret al. Chemistry - A European Journal, 2023, ⟨10.1002/chem.202301420⟩ Article dans une revue hal-04100620v1
Traceless N ‐Polyfluoroalkylation of Weakly Nucleophilic Nitrogen Containing Compounds Laura Santos,Florian Audet,Morgan Donnard,Armen Panossian,Jean‐pierre Vorset al. Chemistry - A European Journal, 2023, ⟨10.1002/chem.202300792⟩ Article dans une revue hal-04100627v1
Reactions of substituted arynes and diphenylphosphine oxide or diphenylphosphine-borane complex toward dibenzophospholes – impact of aryne substituents Marie-Charlotte Belhomme,Thomas Guérin,Armen Panossian,Frédéric R Leroux Phosphorus, Sulfur, and Silicon and the Related Elements, 2023, 198, ⟨10.1080/10426507.2023.2168270⟩ Article dans une revue hal-04057602v1
Direct Deprotonative Functionalization of α,α‐Difluoromethyl Ketones using a Catalytic Organosuperbase Amélia Messara,Armen Panossian,Koichi Mikami,Gilles Hanquet,Frederic Leroux Angewandte Chemie International Edition, In press, ⟨10.1002/anie.202215899⟩ Article dans une revue hal-03933942v1
Exploring F/CF3 substituted oxocarbenium ions for the diastereoselective assembly of highly substituted tetrahydrofurans Anthony J Fernandes,Bastien Michelet,Armen Panossian,Agnès Martin-Mingot,Frédéric R Lerouxet al. Chemical Communications, 2023, 59 (27), pp.4083-4086. ⟨10.1039/d2cc06521e⟩ Article dans une revue hal-04046996v1
New Chemical Transformations Involving SO 2 F 2 ‐Mediated Alcohol Activation Florian Audet,Morgan Donnard,Armen Panossian,David Bernier,Sergii Pazenoket al. Chemical Record, In press, ⟨10.1002/tcr.202300107⟩ Article dans une revue hal-04164625v1
Difluoromethoxylated Ketones as Building Blocks for the Synthesis of Challenging OCF2H‐Bearing N‐Heterocycles. Anaïs Loison,Gilles Hanquet,Fabien Toulgoat,Thierry Billard,Armen Panossianet al. European Journal of Organic Chemistry, 2023, 26 (42), pp.e202300695. ⟨10.1002/ejoc.202300695⟩ Article dans une revue hal-04163739v2
Study of Carbamoyl Fluoride: Synthesis, Properties and Applications Clémence Bonnefoy,Emmanuel Chefdeville,Christian Tourvieille,Armen Panossian,Gilles Hanquetet al. Chemistry - A European Journal, 2022, 28 (43), ⟨10.1002/chem.202201589⟩ Article dans une revue hal-03744602v1
Palladium‐Catalyzed Silylcyanation of Ynamides: Regio‐ and Stereoselective Access to Tetrasubstituted 3‐Silyl‐2‐Aminoacrylonitriles Pierre Hansjacob,Frédéric R. Leroux,Vincent Gandon,Morgan Donnard Angewandte Chemie International Edition, 2022, ⟨10.1002/anie.202200204⟩ Article dans une revue hal-03541070v1
One‐step Oxidative Monofluorination of Electron‐deficient Sulfoxides to Access Highly Lewis Acidic Sulfur(VI) Cations Jordan Berreur,Alberto Diez-Varga,Augustin Manel,Frédéric Leroux,Armen Panossian Chemistry - A European Journal, 2022, ⟨10.1002/chem.202202564⟩ Article dans une revue hal-03795951v1
Ketenimines as Intermediates To Access Difluoromethoxylated Scaffolds Anaïs Loison,Gilles Hanquet,Fabien Toulgoat,Thierry Billard,Armen Panossianet al. Organic Letters, 2022, ⟨10.1021/acs.orglett.2c03283⟩ Article dans une revue hal-03843401v1
Direct Access to 2,3-Disubstituted Amido-Indenones through Annulation of 2-Iodobenzaldehydes with Ynamides Stéphane Golling,Pierre Hansjacob,Nassim Bami,Frédéric R Leroux,Morgan Donnard Journal of Organic Chemistry, 2022, ⟨10.1021/acs.joc.2c02054⟩ Article dans une revue hal-03883448v1
SO2F2-Mediated N-Alkylation of Imino-Thiazolidinones Laura Santos,Morgan Donnard,Armen Panossian,Jean-Pierre Vors,Peter Jeschkeet al. Journal of Organic Chemistry, In press, ⟨10.1021/acs.joc.1c01247⟩ Article dans une revue hal-03325274v1
Recent synthetic methods towards the –OCHF2 moiety Anaïs Loison,Fabien Toulgoat,Thierry Billard,Gilles Hanquet,Armen Panossianet al. Tetrahedron, 2021, 99, pp.132458. ⟨10.1016/j.tet.2021.132458⟩ Article dans une revue hal-03517915v1
Versatile Access to Tetrasubstituted 2-Amidoacroleins through Formal Silylformylation of Ynamides Stéphane Golling,Frédéric R. Leroux,Morgan Donnard Organic Letters, 2021, 23, pp.8093-8097. ⟨10.1021/acs.orglett.1c03141⟩ Article dans une revue hal-03369636v1
Direct trifluoromethoxylation without OCF3 ‐carrier via in‐situ generation of fluorophosgene Jérémy Saiter,Thomas Guérin,Morgan Donnard,Armen Panossian,Gilles Hanquetet al. European Journal of Organic Chemistry, 2021, 2021 (22), ⟨10.1002/ejoc.202100429⟩ Article dans une revue hal-03228836v1
CF3-substituted carbocations: underexploited intermediates with great potential in modern synthetic chemistry Anthony J Fernandes,Armen Panossian,Bastien Michelet,Agnès Martin-Mingot,Frédéric Lerouxet al. Beilstein Journal of Organic Chemistry, 2021, 17, pp.343-378. ⟨10.3762/bjoc.17.32⟩ Article dans une revue hal-03154651v1
Electrophilic fluorosulfoxonium cations as hidden Brønsted acid catalysts in (n+2) annulations of strained cycloalkanes Augustin Manel,Jordan Berreur,Frédéric R. Leroux,Armen Panossian Organic Chemistry Frontiers, In press, ⟨10.1039/D1QO00840D⟩ Article dans une revue hal-03325336v1
The winding road towards an atropo-enantioselective 'ARYNE coupling David Augros,Corinne Comoy,Yves Fort,Frédéric Leroux,Armen Panossian European Journal of Organic Chemistry, 2021, ⟨10.1002/ejoc.202100087⟩ Article dans une revue hal-03170152v1
Aryl Fluoroalkyl Sulfoxides: Optical Stability and p K a Measurement Amélia Messara,Nicolas Vanthuyne,Patrick Diter,Mourad Elhabiri,Armen Panossianet al. European Journal of Organic Chemistry, 2021, 2021 (36), ⟨10.1002/ejoc.202100816⟩ Article dans une revue hal-03319682v1
Study of a Stable “Trifluoromethoxide Anion Solution” Arising from 2,4‐Dinitro‐Trifluoromethoxybenzene Clémence Bonnefoy,Emmanuel Chefdeville,Armen Panossian,Gilles Hanquet,Frédéric R. Lerouxet al. Chemistry - A European Journal, 2021, 27 (64), pp.15986-15991. ⟨10.1002/chem.202102809⟩ Article dans une revue hal-03582991v1
Practical Synthesis and Application of Halogen-Doped Pyrrole Building Blocks Andrej Emanuel Cotman,Thomas Guérin,Ivana Kovačević,Davide Benedetto Tiz,Martina Durciket al. ACS Omega, 2021, 6 (14), pp.9723-9730. ⟨10.1021/acsomega.1c00331⟩ Article dans une revue hal-03228819v1
Synthesis of 3-Amino-5-fluoroalkylfurans by Intramolecular Cyclization Clotilde Plaçais,Morgan Donnard,Armen Panossian,Jean-Pierre Vors,David Bernieret al. Organic Letters, 2021, 23 (12), pp.4915-4919. ⟨10.1021/acs.orglett.1c01672⟩ Article dans une revue hal-03325240v1
Formation of synthetically relevant CF3-substituted phenonium ions in superacid media Anthony J Fernandes,Bastien Michelet,Armen Panossian,Agnès Martin-Mingot,Frédéric R. Lerouxet al. RSC Advances, 2021, 11 (41), pp.25695 - 25699. ⟨10.1039/d1ra04901a⟩ Article dans une revue hal-03325280v1
Deprotonative Functionalization of the Difluoromethyl Group Laura Santos,Armen Panossian,Morgan Donnard,Jean-Pierre Vors,Sergii Pazenoket al. Organic Letters, 2020, ⟨10.1021/acs.orglett.0c03380⟩ Article dans une revue hal-02989088v1
Synthesis and Use of Trifluoromethylthiolated Ketenimines Frédéric R. Leroux,Thomas Guérin,Nadiia Pikun,Ryutaro Morioka,Armen Panossianet al. Chemistry - A European Journal, 2020, ⟨10.1002/chem.202002723⟩ Article dans une revue hal-02990038v1
Transition-Metal-Free Heterobiaryl Synthesis via Aryne Coupling Tarak Saied,Catherine Demangeat,Armen Panossian,Frédéric Leroux,Yves Fortet al. European Journal of Organic Chemistry, 2019, 2019 (31-32), pp.5275-5284. ⟨10.1002/ejoc.201900130⟩ Article dans une revue hal-02186792v1
Efficient asymmetric synthesis of aryl difluoromethyl sulfoxides and their use to access enantiopure α-difluoromethyl alcohols Chloé Batisse,Maria Cespedes Davila,Marco Castello,Amélia Messara,Bertrand Vivetet al. Tetrahedron, 2019, 75 (23), pp.3063-3079. ⟨10.1016/j.tet.2019.04.037⟩ Article dans une revue hal-02400108v1
Transition-Metal-Free Approach for the Direct Arylation of Thiophene: Experimental and Theoretical Investigations towards the (Het)-Aryne Route Catherine Demangeat,Tarak Saied,Romain Ramozzi,Francesca Ingrosso,Manuel Ruiz-Lopezet al. European Journal of Organic Chemistry, 2019, 2019 (2-3), pp.547-556. ⟨10.1002/ejoc.201801173⟩ Article dans une revue hal-02186820v1
A physico-chemical investigation of fluorine-enriched quinolines Fallia Aribi,Armen Panossian,Denis Jacquemin,Jean-Pierre Vors,Sergii Pazenoket al. New Journal of Chemistry, 2018, 42 (12), pp.10036-10047. ⟨10.1039/c8nj00916c⟩ Article dans une revue hal-02105499v1
Access towards enantiopure α,α-difluoromethyl alcohols by means of sulfoxides as traceless chiral auxiliaries Chloé Batisse,Armen Panossian,Gilles Hanquet,Frédéric Leroux Chemical Communications, 2018, 54 (74), pp.10423-10426. ⟨10.1039/C8CC05571H⟩ Article dans une revue hal-02150060v1
A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation Timothée Naret,Jérôme Bignon,Guillaume Bernadat,Mohamed Benchekroun,Helene Levaiqueet al. European Journal of Medicinal Chemistry, 2018, 143, pp.473-490. ⟨10.1016/j.ejmech.2017.11.055⟩ Article dans une revue hal-02105508v1
Stereoselectivity Switch in the Trapping of Polar Organometallics with Andersen’s Reagent—Access to Highly Stereoenriched Transformable Biphenyls Julien Bortoluzzi,Vishwajeet Jha,Guillaume Levitre,Mickaël Fer,Jordan Berreuret al. Journal of Organic Chemistry, 2018, 83 (15), pp.7751-7761. ⟨10.1021/acs.joc.8b00648⟩ Article dans une revue hal-02105503v1
Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites Chelliah Selvam,Isabelle Lemasson,Isabelle Brabet,Nadia Oueslati,Berin Karamanet al. Journal of Medicinal Chemistry, 2018, 61 (5), pp.1969-1989. ⟨10.1021/acs.jmedchem.7b01438⟩ Article dans une revue hal-02018007v1
New synthetic access to 3-fluoroalkyl-5-pyrazolecarboxylates and carboxylic acids Alberto Gomez Herrera,Etienne Schmitt,Armen Panossian,Jean-Pierre Vors,Sergiy Pazenoket al. Journal of Fluorine Chemistry, 2018, 214, pp.17-23. ⟨10.1016/j.jfluchem.2018.07.010⟩ Article dans une revue hal-02105504v1
Synthesis of Mono- and Bis(fluoroalkyl)pyrimidines from FARs, Fluorinated Acetoacetates, and Malononitrile Provides Easy Access to Novel High-Value Pyrimidine Scaffolds E. Schmitt,B. Commare,A. Panossian,J.-P. Vors,S. Pazenoket al. Chemistry - A European Journal, 2018, 24 (6), pp.1311-1316. ⟨10.1002/chem.201703982⟩ Article dans une revue hal-02105509v1
Towards biphenyl based frustrated Lewis pairs Julien Bortoluzzi,Frédéric Leroux,Armen Panossian Abstracts of Papers of the American Chemical Society, 2018, 256 Article dans une revue hal-04889950v1
2,4-Bis(fluoroalkyl)quinoline-3-carboxylates as Tools for the Development of Potential Agrochemical Ingredients Fallia Aribi,Armen Panossian,Jean-Pierre Vors,Sergiy Pazenok,Frédéric R. Leroux European Journal of Organic Chemistry, 2018, Organofluorine Chemistry in Europe, 2018 (27-28), pp.3792-3802. ⟨10.1002/ejoc.201800375⟩ Article dans une revue hal-02105501v1
Control of axial chirality in absence of transition metals based on arynes Frédéric R. Leroux,Armen Panossian,David Augros Comptes Rendus. Chimie, 2017, 20 (6), pp.682-692. ⟨10.1016/j.crci.2016.12.001⟩ Article dans une revue hal-02105315v1
Fluoroalkyl Amino Reagents for the Introduction of the Fluoro(trifluoromethoxy)methyl Group onto Arenes and Heterocycles Etienne Schmitt,Sebastien Bouvet,Bruce Pegot,Armen Panossian,Jean-Pierre Vorset al. Organic Letters, 2017, 19 (18), pp.4960-4963. ⟨10.1021/acs.orglett.7b02444⟩ Article dans une revue hal-02105321v1
Switchable Diastereoselectivity in the Fluoride-Promoted Vinylogous Mukaiyama–Michael Reaction of 2-[(Trimethylsilyl)oxy]furan Catalyzed by Crown Ethers Giorgio Della Sala,Marina Sicignano,Rosaria Schettini,Francesco de Riccardis,Luigi Cavalloet al. Journal of Organic Chemistry, 2017, 82 (13), pp.6629-6637. ⟨10.1021/acs.joc.7b00743⟩ Article dans une revue hal-02105791v1
Le fluor, un élément qui vous veut du bien Frédéric Leroux L'Actualité Chimique, 2017, 421 Article dans une revue hal-05020031v1
Fluoroalkyl Amino Reagents (FARs): A General Approach towards the Synthesis of Heterocyclic Compounds Bearing Emergent Fluorinated Substituents Bruno Commare,Etienne Schmitt,Fallia Aribi,Armen Panossian,Jean-Pierre Vorset al. Molecules, 2017, 22 (6), pp.977. ⟨10.3390/molecules22060977⟩ Article dans une revue hal-02105792v1
Tri- and difluoromethoxylated N-based heterocycles − Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid Grégory Landelle,Etienne Schmitt,Armen Panossian,Jean-Pierre Vors,Sergiy Pazenoket al. Journal of Fluorine Chemistry, 2017, 203, pp.155-165. ⟨10.1016/j.jfluchem.2017.08.006⟩ Article dans une revue hal-02105310v1
Asymmetric α-Sulfonyl- and α-Phosphoryl-Oxylation of Ketones by a Chiral Hypervalent Iodine(III) Guillaume Levitre,Audrey Dumoulin,Pascal Retailleau,Armen Panossian,Frederic R. Lerouxet al. Journal of Organic Chemistry, 2017, 82 (22), pp.11877-11883. ⟨10.1021/acs.joc.7b01597⟩ Article dans une revue hal-02105318v1
Transition-Metal-Free Synthesis of a Known Intermediate in the Formal Synthesis of (-)-Steganacin David Augros,Boubacar Yalcouye,Sabine Choppin,Matthieu Chessé,Armen Panossianet al. European Journal of Organic Chemistry, 2017, 2017 (3), pp.497-503. ⟨10.1002/ejoc.201601239⟩ Article dans une revue hal-02105793v1
When Chirality Meets “Buchwald-Type” Phosphines: Synthesis and Evaluation in Frustrated Lewis Pair-, Lewis Base- and Palladium-Promoted Asymmetric Catalysis Frédéric R. Leroux,Mickaël Fer,Joséphine Cinqualbre,Julien Bortoluzzi,Matthieu Chesséet al. European Journal of Organic Chemistry, 2016, 2016 (26), pp.4545-4553. ⟨10.1002/ejoc.201600727⟩ Article dans une revue istex hal-03004119v1
A Major Advance in the Synthesis of Fluoroalkyl Pyrazoles: Tuneable Regioselectivity and Broad Substitution Patterns Etienne Schmitt,Armen Panossian,Jean-Pierre Vors,Christian Funke,Norbert Luiet al. Chemistry - A European Journal, 2016, 22 (32), pp.11239-11244. ⟨10.1002/chem.201601621⟩ Article dans une revue hal-03004108v1
Access to Atropisomerically Enriched Biaryls by the Coupling of Aryllithiums with Arynes under Control by Homochiral Oxazolines Boubacar Yalcouye,Anaïs Brehier,David Augros,Armen Panossian,Sabine Choppinet al. European Journal of Organic Chemistry, 2016, 2016 (4), pp.725-732. ⟨10.1002/ejoc.201501503⟩ Article dans une revue istex hal-02304102v1
Atropo-diastereoselective coupling of aryllithiums and arynes — variations around the chiral auxiliary Frédéric R. Leroux,David Augros,Boubacar Yalcouye,Anaïs Berthelot-Bréhier,Matthieu Chesséet al. Tetrahedron, 2016, 72 (34), pp.5208-5220. ⟨10.1016/j.tet.2016.01.047⟩ Article dans une revue istex hal-03004140v1
A new approach toward the synthesis of 2,4-bis(fluoroalkyl)-substituted quinoline derivatives using fluoroalkyl amino reagent chemistry Fallia Aribi,Etienne Schmitt,Armen Panossian,Jean-Pierre Vors,Sergiy Pazenoket al. Organic Chemistry Frontiers, 2016, 3 (11), pp.1392-1415. ⟨10.1039/C6QO00319B⟩ Article dans une revue hal-03004130v1
Lithium/Element Exchange as an Efficient Tool for Accessing Atropo-enriched Biaryls &lt;i&gt;via&lt;/i&gt; Arynes Armen Panossian,Frédéric Leroux CHIMIA, 2016, 70 (1), pp.43-47. ⟨10.2533/chimia.2016.43⟩ Article dans une revue hal-03004175v1
The French Connection : Editorial Frédéric R. Leroux CHIMIA, 2016, 70 (1-2), pp.6-7 Article dans une revue hal-04876344v1
Determination of the absolute configuration of phosphinic analogues of glutamate Bruno Commare,Delphine Rigault,Isabelle Lemasson,Patrick Deschamps,Alain Tomaset al. Organic & Biomolecular Chemistry, 2015, 13 (4), pp.1106-1112. ⟨10.1039/C4OB01960A⟩ Article dans une revue hal-02268872v1
In Situ Generated Fluorinated Iminium Salts for Difluoromethylation and Difluoroacetylation Frédéric R. Leroux,Etienne Schmitt,Baptiste Rugeri,Armen Panossian,Jean-Pierre Vorset al. Organic Letters, 2015, 17 (18), pp.4510-4513. ⟨10.1021/acs.orglett.5b02184⟩ Article dans une revue hal-03004193v1
Atroposelective synthesis of axially chiral P,S-ligands based on arynes Anais Berthelot-Brehier,Armen Panossian,Francoise Colobert-Leuenberger,Frédéric Leroux Organic Chemistry Frontiers, 2015, 2 (6), pp.634-644. ⟨10.1039/C5QO00067J⟩ Article dans une revue hal-02306240v1
Unusual phosphine oxidation: new triazolopyridyl-quinolyl phosphine oxide fluorescent dyes R. Ballesteros-Garrido,B. Abarca,R. Ballesteros,F. Colobert,Frédéric R. Lerouxet al. RSC Advances, 2015, 5 (38), pp.29809-29813. ⟨10.1039/C5RA04386G⟩ Article dans une revue hal-03004215v1
Modular Synthesis of Biaryl-Substituted Phosphine Ligands: Application in Microwave-Assisted Palladium-Catalyzed C-N Cross-Coupling Reactions Chandani Singh,Jayant Rathod,Vishwajeet Jha,Armen Panossian,Pradeep Kumaret al. European Journal of Organic Chemistry, 2015, 2015 (29), pp.6515-6525. ⟨10.1002/ejoc.201500962⟩ Article dans une revue istex hal-02304103v1
Recent advances and new concepts for the synthesis of axially stereoenriched biaryls Joanna Wencel‐delord,Armen Panossian,Frédéric Leroux,Françoise Colobert Chemical Society Reviews, In press, ⟨10.1039/c5cs00012b⟩ Article dans une revue hal-02305225v1
Substituent effects on the relative rates and free energies of ortho-lithiation reactions: families of fluorobenzenes as the substrates F Mongin,C Curty,E Marzi,Frédéric Leroux,M Schlosser ARKIVOC - Online Journal of Organic Chemistry, 2015, 4, pp.48-65. ⟨10.3998/ark.5550190.p008.926⟩ Article dans une revue hal-02304104v1
Multi-nuclear NMR of axially chiral biaryls in polypeptide orienting solvents: spectral discriminations and enantiorecognition mechanisms Philippe Berdagué,Jose-Enrique Herbert-Pucheta,Vishwajeet Jha,Armen Panossian,Frédéric Lerouxet al. New Journal of Chemistry, 2015, 39 (12), pp.9504-9517. ⟨10.1039/c5nj01434d⟩ Article dans une revue hal-02314357v1
Synthesis and biological evaluation of new nucleosides derived from trifluoromethoxy-4-quinolones Kristína Plevová,Katarína Briestenská,Francoise Colobert-Leuenberger,Jela Mistríková,Viktor Milataet al. Tetrahedron Letters, 2015, 56 (36), pp.5112-5115. ⟨10.1016/j.tetlet.2015.07.031⟩ Article dans une revue hal-02305222v1
Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands Frédéric R. Leroux,Julien Graff,Elżbieta Łastawiecka,Laure Guénée,Frédéric Lerouxet al. Advanced Synthesis and Catalysis, 2015, 357 (13), pp.2833-2839. ⟨10.1002/adsc.201500323⟩ Article dans une revue istex hal-03004211v1
Tribute to Prof. Manfred Schlosser (1934-2013) Obituary Renzo Ruzziconi,Frédéric Leroux Journal of Fluorine Chemistry, 2015, 171, pp.2-3. ⟨10.1016/j.jfluchem.2014.09.014⟩ Article dans une revue hal-02304109v1
A General Approach towards NH-Pyrazoles That Bear Diverse Fluoroalkyl Groups by Means of Fluorinated Iminium Salts Étienne Schmitt,Gregory Landelle,Jean-Pierre Vors,Norbert Lui,Sergiy Pazenoket al. European Journal of Organic Chemistry, 2015, 27, pp.6052-6060. ⟨10.1002/ejoc.201500920⟩ Article dans une revue istex hal-02305226v1
Novel C1-symmetric dibenzophosphole ligands: application in hydroformylation reactions Abdelouahd Oukhrib,Laurence Bonnafoux,Armen Panossian,Sandrine Waifang,Duc Hanh Nguyenet al. Tetrahedron, 2014, 70 (7), pp.1431-1436. ⟨10.1016/j.tet.2014.01.003⟩ Article dans une revue istex hal-00992450v1
Trifluoromethyl Ethers and -Thioethers as Tools for Medicinal Chemistry and Drug Discovery Gregory Landelle,Armen Panossian,Frédéric Leroux Current Topics in Medicinal Chemistry, 2014, 14 (7), pp.941-951 Article dans une revue hal-02306242v1
Fluorine Chemistry Special Feature Frédéric Leroux,Mark Ford,Sergiy Pazenok Organic Process Research and Development, 2014, 18 (8), ⟨10.1021/op500216s⟩ Article dans une revue hal-02306238v1
A theoretical and experimental study of the racemization process of hexaaza[5]helicenes Belen Abarca,Rafael Ballesteros,Rosa Adam,Rafael Ballesteros-Garrido,Frédéric Lerouxet al. Tetrahedron, 2014, 70 (45), pp.8750-8757. ⟨10.1016/j.tet.2014.09.018⟩ Article dans une revue hal-02307797v1
A concise atroposelective formal synthesis of (-)-steganone Boubacar Yalcouye,Sabine Choppin,Armen Panossian,Frédéric Leroux,Francoise Colobert-Leuenberger European Journal of Organic Chemistry, 2014, 2014 (28), pp.6285-6294. ⟨10.1002/ejoc.201402761⟩ Article dans une revue istex hal-02304105v1
A New Synthesis and Process Development of Bis(fluoroalkyl)pyrazoles As Novel Agrophores F Giornal,G Landelle,N Lui,J Vors,S Pazenoket al. Organic Process Research and Development, 2014, 18 (8), pp.1002-1009. ⟨10.1021/Op500102h⟩ Article dans une revue hal-02342504v1
Recent advances in transition metal-catalyzed Csp(2)-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation Gregory Landelle,Armen Panossian,Sergiy Pazenok,Jean-Pierre Vors,Frédéric Leroux Beilstein Journal of Organic Chemistry, 2013, 9, pp.2476-2536. ⟨10.3762/bjoc.9.287⟩ Article dans une revue hal-02304098v1
Convenient and Reliable Routes Towards 2-Aminothiazoles: Palladium-Catalyzed versus Copper-Catalyzed Aminations of Halothiazoles Stéphanie Toulot,Timo Heinrich,Frédéric Leroux Advanced Synthesis and Catalysis, 2013, 355 (16), pp.3263-3272. ⟨10.1002/adsc.201300591⟩ Article dans une revue hal-02342506v1
Manfred Schlosser (1934-2013) Obituary Frédéric Leroux Angewandte Chemie International Edition, 2013, 52 (48), ⟨10.1002/anie.201308231⟩ Article dans une revue istex hal-02307800v1
Synthesis and structural properties of hexaaza[5]helicene containing two [1,2,3]triazolo[1,5-a]pyridine moieties Rosa Adam,Rafael Ballesteros-Garrido,Oriol Vallcorba,Belen Abarca,Rafael Ballesteroset al. Tetrahedron Letters, 2013, 54 (32), pp.4316-4319. ⟨10.1016/j.tetlet.2013.06.014⟩ Article dans une revue istex hal-02306243v1
A New Life for an Old Reagent: Fluoroalkyl Amino Reagents as Efficient Tools for the Synthesis of Diversely Fluorinated Pyrazoles Sergiy Pazenok,Florence Giornal,Grégory Landelle,Norbert Lui,Jean-Pierre Vorset al. European Journal of Organic Chemistry, 2013, 2013 (20), pp.4249-4253. ⟨10.1002/ejoc.201300561⟩ Article dans une revue istex hal-03004227v1
Palladium-Catalyzed Intramolecular Direct Arylation of 2-Bromo-diaryl Sulfoxides via C-H Bond Activation Thomas Wesch,Anaïs Brehier,Frédéric Leroux,Francoise Colobert-Leuenberger Organic Letters, 2013, 15 (10), pp.2490-2493. ⟨10.1021/ol400966q⟩ Article dans une revue hal-02304107v1
Atropodiastereoselective C-H Olefination of Biphenyl p-Tolyl Sulfoxides with Acrylates Thomas Wesch,Frédéric Leroux,Francoise Colobert-Leuenberger Advanced Synthesis and Catalysis, 2013, 355 (11-12), pp.2139-2144. ⟨10.1002/adsc.201300446⟩ Article dans une revue istex hal-02304106v1
Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients Florence Giornal,Lars Rodefeld,Norbert Lui,Jean-Pierre Vors,Frédéric Leroux Journal of Fluorine Chemistry, 2013, 152, pp.2-11. ⟨10.1016/j.jfluchem.2012.11.008⟩ Article dans une revue istex hal-02307799v1
Aryne-mediated fluorination: Synthesis of fluorinated biaryls via a sequential desilylation-halide elimination-fluoride addition process Vincent Diemer,Juan Garcia,Frédéric Leroux,Francoise Colobert-Leuenberger Journal of Fluorine Chemistry, 2012, 134, pp.146-155. ⟨10.1016/j.jfluchem.2011.02.017⟩ Article dans une revue istex hal-02306231v1
Triazolopyridines. Part 28. The ring-chain isomerization strategy: triazolopyridine- and triazoloquinoline-pyridine based fluorescence ligands Rafael Ballesteros-Garrido,Estefania Delgado-Pinar,Belen Abarca,Rafael Ballesteros,Frédéric Lerouxet al. Tetrahedron, 2012, 68 (19), pp.3701-3707. ⟨10.1016/j.tet.2012.03.029⟩ Article dans une revue istex hal-02306237v1
Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki-Miyaura coupling Timo Leermann,Pierre-Emmanuel Broutin,Frédéric Leroux,Francoise Colobert-Leuenberger Organic & Biomolecular Chemistry, 2012, 10 (20), pp.4095-4102. ⟨10.1039/c2ob25373a⟩ Article dans une revue hal-02306241v1
Stereoselective Synthesis of P-Chirogenic Dibenzophosphole-Boranes via Aryne Intermediates Vincent Diemer,Anaïs Brehier,Jérôme Bayardon,Sylvain Juge,Frédéric Lerouxet al. Journal of Organic Chemistry, 2012, 77 (14), pp.6117-6127. ⟨10.1021/jo3009098⟩ Article dans une revue hal-02306244v1
Transition-Metal-Free Atropo-Selective Synthesis of Biaryl Compounds Based on Arynes Frédéric Leroux,Anaïs Brehier,Laurence Bonnafoux,Armen Panossian,Francoise Colobert-Leuenberger Chemistry - A European Journal, 2012, 18 (45), pp.14232-14236. ⟨10.1002/chem.201202739⟩ Article dans une revue istex hal-02306232v1
Stereoselective Synthesis of o -Bromo (or Iodo)aryl P-Chirogenic Phosphines Based on Aryne Chemistry Frédéric R. Leroux,Jérôme Bayardon,Hugo Laureano,Vincent Diemer,Mathieu Dutartreet al. Journal of Organic Chemistry, 2012, 77 (13), pp.5759-5769. ⟨10.1021/jo300910w⟩ Article dans une revue hal-03004233v1
Highly Efficient One-Pot Access to Functionalized Arylboronic Acids via Noncryogenic Bromine/Magnesium Exchanges Timo Leermann,Frédéric Leroux,Francoise Colobert-Leuenberger Organic Letters, 2011, 13 (17), pp.4479-4481. ⟨10.1021/ol2016252⟩ Article dans une revue hal-02305220v1
Bromine-lithium exchange: An efficient tool in the modular construction of biaryl ligands Laurence Bonnafoux,Frédéric Leroux,Francoise Colobert-Leuenberger Beilstein Journal of Organic Chemistry, 2011, 7, pp.1278-1287. ⟨10.3762/bjoc.7.148⟩ Article dans une revue hal-02307798v1
Polar Organometallic Chemistry Frédéric Leroux Current Organic Chemistry, 2011, 15 (13) Article dans une revue hal-02305223v1
Catalytic Palladium Phosphination: Modular Synthesis of C1-Symmetric Biaryl-Based Diphosphines Laurence Bonnafoux,Rafael Gramage-Doria,Francoise Colobert,Frederic R. Leroux Chemistry - A European Journal, 2011, 17 (39), pp.11008-11016. ⟨10.1002/chem.201101529⟩ Article dans une revue istex hal-01472931v1
Efficient and Complementary Methods Offering Access to Synthetically Valuable 1,2-Dibromobenzenes Vincent Diemer,Frédéric Leroux,Francoise Colobert-Leuenberger European Journal of Organic Chemistry, 2011, 2, pp.327-340. ⟨10.1002/ejoc.201001217⟩ Article dans une revue istex hal-02306234v1
Through-Space J(P,P) and J(P,F) Spin-Spin Coupling in C-1-Symmetric Biaryl Diphosphanes Laurence Bonnafoux,Ludger Ernst,Frédéric Leroux,Francoise Colobert-Leuenberger European Journal of Inorganic Chemistry, 2011, 22, pp.3387-3397. ⟨10.1002/ejic.201100428⟩ Article dans une revue istex hal-02306233v1
Regioselectivity in the Aryne Cross-Coupling of Aryllithiums with Functionalized 1,2-Dibromobenzenes Vincent Diemer,Manon Begaud,Frédéric Leroux,Francoise Colobert-Leuenberger European Journal of Organic Chemistry, 2011, 2, pp.341-354. ⟨10.1002/ejoc.201001283⟩ Article dans une revue istex hal-02306235v1
[1,2,3]Triazolo[1,5-a]pyridyl phosphines reflecting the influence of phosphorus lone pair orientation on spectroscopic properties Rafael Ballesteros-Garrido,Laurence Bonnafoux,Fernando Blanco,Rafael Ballesteros,Frédéric Lerouxet al. Dalton Transactions, 2011, 40 (6), pp.1387-1395. ⟨10.1039/C0DT01183E⟩ Article dans une revue hal-02306239v1
A General Approach to (Trifluoromethoxy)pyridines: First X-ray Structure Determinations and Quantum Chemistry Studies Baptiste Manteau,Pierre Genix,Lydia Brelot,Jean-Pierre Vors,Sergiy Pazenoket al. European Journal of Organic Chemistry, 2010, 2010 (31), pp.6043-6066. ⟨10.1002/ejoc.201000958⟩ Article dans une revue istex hal-03370334v1
2,2′,6-Tribromobiphenyl via Transition-Metal-Free ARYNE Coupling: A Valuable Tool in the Synthesis of Biphenyls Frédéric R. Leroux,Laurence Bonnafoux,Françoise Colobert SYNLETT, 2010, 2010 (19), pp.2953-2955. ⟨10.1055/s-0030-1259025⟩ Article dans une revue hal-03366549v1
Efficient synthesis of quaternary and P-stereogenic phosphonium triflates Emmanuelle Remond,Arnaud Tessier,Frédéric Leroux,Jérome Bayardon,Sylvain Jugé Organic Letters, 2010, 12 (7), pp.1568-1571. ⟨10.1021/ol100304c⟩ Article dans une revue hal-00474388v1
New trends in the chemistry of α-fluorinated ethers, thioethers, amines and phosphines Baptiste Manteau,Sergiy Pazenok,Jean-Pierre Vors,Frédéric Leroux Journal of Fluorine Chemistry, 2010, 131 (2), pp.140-158. ⟨10.1016/j.jfluchem.2009.09.009⟩ Article dans une revue istex hal-04922903v1
The deprotonative metalation of [1,2,3]triazolo[1,5-a]quinoline. Synthesis of 8-haloquinolin-2-carboxaldehydes Rafael Ballesteros-Garrido,Frédéric Leroux,Rafael Ballesteros,Belén Abarca,Françoise Colobert Tetrahedron, 2009, 65 (22), pp.4410-4417. ⟨10.1016/j.tet.2009.03.058⟩ Article dans une revue istex hal-04806388v1
The [1,2,3]Triazolo[1,5-a]pyridine ring: A sensitive sensor for the electronic profile of phosphorus substituents Rafael Ballesteros-Garrido,Laurence Bonnafoux,Frédéric Leroux,Belén Abarca,Françoise Colobert Dalton Transactions, 2009, 26, pp.5068. ⟨10.1039/b906034k⟩ Article dans une revue istex hal-04806264v1
[1,2,3]Triazolo[1,5-a]pyridine derivatives as molecular chemosensors for zinc(ii), nitrite and cyanide anions Rafael Ballesteros-Garrido,Belén Abarca,Rafael Ballesteros,Carmen Ramírez de Arellano,Frédéric Lerouxet al. New Journal of Chemistry, 2009, 33 (10), pp.2102. ⟨10.1039/b906992e⟩ Article dans une revue istex hal-04796129v1
3‐(Pyridin‐2‐yl)[1,2,3]triazolo[1,5‐ a ]quinoline: A Theoretical and Experimental Analysis of Ring‐Chain Isomerisation Rafael Ballesteros-Garrido,Fernando Blanco,Rafael Ballesteros,Frédéric Leroux,Belén Abarcaet al. European Journal of Organic Chemistry, 2009, 2009 (33), pp.5765-5778. ⟨10.1002/ejoc.200900818⟩ Article dans une revue istex hal-04796106v1
Axial Chirality Control During Suzuki−Miyaura Cross-Coupling Reactions: The tert -Butylsulfinyl Group as an Efficient Chiral Auxiliary Françoise Colobert,Victoria Valdivia,Sabine Choppin,Frédéric Leroux,Inmaculada Fernándezet al. Organic Letters, 2009, 11 (22), pp.5130-5133. ⟨10.1021/ol9020755⟩ Article dans une revue hal-04806270v1
Triazolopyridines. Part 26: The preparation of novel [1,2,3]triazolo[1,5-a]pyridine sulfoxides Belén Abarca,Rafael Ballesteros,Rafael Ballesteros-Garrido,Françoise Colobert,Frédéric Leroux Tetrahedron, 2008, 64 (17), pp.3794-3801. ⟨10.1016/j.tet.2008.02.011⟩ Article dans une revue istex hal-05056518v1
Trifluoromethyl ethers – synthesis and properties of an unusual substituent Frédéric Leroux,Baptiste Manteau,Jean-Pierre Vors,Sergiy Pazenok Beilstein Journal of Organic Chemistry, 2008, 4, ⟨10.3762/bjoc.4.13⟩ Article dans une revue hal-04923007v1
Efficient palladium catalyzed synthesis of heteroaromatic sulfoxides Françoise Colobert,Rafael Ballesteros-Garrido,Frédéric Leroux,Rafael Ballesteros,Belén Abarca Tetrahedron Letters, 2007, 48 (39), pp.6896-6899. ⟨10.1016/j.tetlet.2007.07.165⟩ Article dans une revue istex hal-04922779v1
First Modular Synthesis of Dissymmetric Biaryldiphosphine Ligands Allowing Tunable Steric and Electronic Effects Frédéric R. Leroux,Hanspeter Mettler Advanced Synthesis and Catalysis, 2007, 349 (3), pp.323-336. ⟨10.1002/adsc.200600300⟩ Article dans une revue istex hal-04730716v1
The first stereoselective Pd-catalyzed addition of boronic acids onto aldehydes Alexandra Novodomskà,Mària Dudičovà,Frédéric Leroux,Françoise Colobert Tetrahedron: Asymmetry, 2007, 18 (13), pp.1628-1634. ⟨10.1016/j.tetasy.2007.06.031⟩ Article dans une revue istex hal-04922796v1
Relative carbanion basicities as driving force for an intramolecular silyl migration of lithiated biphenyls Laurence Bonnafoux,Rosario Scopelliti,Frédéric Leroux,Françoise Colobert Tetrahedron Letters, 2007, 48 (49), pp.8768-8772. ⟨10.1016/j.tetlet.2007.10.004⟩ Article dans une revue hal-05056507v1
Triazolopyridines. Part 25: Synthesis of new chiral ligands from [1,2,3]triazolo[1,5-a]pyridines Belén Abarca,Rafael Ballesteros,Rafael Ballesteros-Garrido,Françoise Colobert,Frédéric Leroux Tetrahedron, 2007, 63 (42), pp.10479-10485. ⟨10.1016/j.tet.2007.07.101⟩ Article dans une revue istex hal-04922984v1
A Practical Transition Metal‐Free Aryl‐Aryl Coupling Method: Arynes as Key Intermediates Frédéric R. Leroux,Laurence Bonnafoux,Christophe Heiss,Françoise Colobert,Don Antoine Lanfranchi Advanced Synthesis and Catalysis, 2007, 349 (17-18), pp.2705-2713. ⟨10.1002/adsc.200700211⟩ Article dans une revue istex hal-04734933v1
Inhibitors of Steroidal Cytochrome P450 Enzymes as Targets for Drug Development Eckhard Baston,Frederic Leroux Recent Patents on Anti-Cancer Drug Discovery, 2007, 2 (1), pp.31-58. ⟨10.2174/157489207779561453⟩ Article dans une revue hal-04922843v1
α-Fluorinated Ethers as “Exotic” Entity in Medicinal Chemistry Peter Jeschke,Eckhard Baston,Frederic Leroux Mini-Reviews in Medicinal Chemistry, 2007, 7 (10), pp.1027-1034. ⟨10.2174/138955707782110150⟩ Article dans une revue istex hal-04796073v1
New Vistas in Halogen/Metal Exchange Reactions: The Discrimination Between Seemingly Equal Halogens Laurence Bonnafoux,Nathalie Nicod,Frederic Leroux,Berengere Quissac,Francoise Colobert Letters in Organic Chemistry, 2006, 3 (2), pp.165-169. ⟨10.2174/157017806775224279⟩ Article dans une revue hal-04922911v1
A Highly Efficient Low Temperature Modification of the Classical Ullmann Reaction Frederic Leroux,Roger Simon,Nathalie Nicod Letters in Organic Chemistry, 2006, 3 (12), pp.948-954. ⟨10.2174/157017806779467979⟩ Article dans une revue istex hal-04922815v1
Ligand Tailoring: The First Modular Assembly of Atropisomeric Biarylbisphosphine Ligands Frédéric Leroux,Hanspeter Mettler SYNLETT, 2006, 5, pp.0766-0770. ⟨10.1055/s-2006-933107⟩ Article dans une revue hal-04922860v1
The Effect of Ring Size on Reactivity: The Diagnostic Value of ‘Rate Profiles’ Eric Masson,Frédéric Leroux Helvetica Chimica Acta, 2005, 88 (6), pp.1375-1386. ⟨10.1002/hlca.200590110⟩ Article dans une revue istex hal-04922759v1
Palladium-Catalyzed Borylation of Phenyl Bromides and Application in One-Pot Suzuki−Miyaura Biphenyl Synthesis Pierre-Emmanuel Broutin,Igor Čerňa,Maria Campaniello,Frédéric Leroux,Françoise Colobert Organic Letters, 2004, 6 (24), pp.4419-4422. ⟨10.1021/ol048303b⟩ Article dans une revue hal-04922941v1
N-(4-biphenylmethyl)imidazoles as potential therapeutics for the treatment of prostate cancer Frédéric Leroux,T Hutschenreuter,C Charriere,R Scopelliti,R Hartmann Helvetica Chimica Acta, 2003, 86 (7), pp.2671-2686. ⟨10.1002/hlca.200390217⟩ Article dans une revue hal-05256670v1

Communication dans un congrès (1)

Access to heterocycles bearing emergent fluorinated substituents - as FAR as possible! Etienne Schmitt,Fallia Aribi,Armen Panossian,Jean-Pierre Vors,Sergiy Pazenoeket al. 253rd American Chemical Society National Meeting & Exposition, April 2-6, 2017, San Francisco, Apr 2017, San Francisco, United States Communication dans un congrès hal-04876291v1

Poster de conférence (4)

Carbamoyl Fluorides: From Synthesis to Radiochemistry Clémence Bonnefoy,Emmanuel Chefdeville,Armen Panossian,Gilles Hanquet,Frédéric R. Lerouxet al. 28th French-Japanese Symposium on Medicinal & Fine Chemistry, Oct 2023, Nice, France Poster de conférence hal-04720313v1
Carbamoyl fluorides: from synthesis to radiochemistry Clémence Bonnefoy,Emmanuel Chefdeville,Armen Panossian,Gilles Hanquet,Frédéric R. Lerouxet al. 57th International Conference on Medicinal Chemistry, Jul 2023, Lille, France Poster de conférence hal-04720307v1
Carbamoyl fluoride as a potential new tag for fluorine-18 labeling Clémence Bonnefoy,Christian Tourvieille,Armen Panossian,Gilles Hanquet,Frédéric R. Lerouxet al. 24th International Symposium on Radiopharmaceutical Sciences, May 2022, Nantes, France Poster de conférence hal-04720303v1
2,4-Dinitro-trifluoromethoxybenzene: a promising reagent in fluorine chemistry Clémence Bonnefoy,Emmanuel Chefdeville,Christian Tourvielle,Armen Panossian,Gilles Hanquetet al. 55th Bürgenstock Conference, May 2022, Brunnen, Switzerland Poster de conférence hal-04720299v1

Ouvrages (2)

Fluorine in life sciences : pharmaceutical, medicinal diagnostics, and agrochemicals Günter Haufe,Frédéric R. Leroux Elsevier, 4, pp.1-686, 2019, Progress in Fluorine Science Series, Alain Tressaud, 978-0-12-812733-9. ⟨10.1016/C2016-0-03808-1⟩ Ouvrages hal-02146258v1
Modern synthesis processes and reactivity of fluorinated compounds Henri Groult,Alain Tressaud,Frédéric R. Leroux Elsevier, 3, pp.1-772, 2017, Progress in Fluorine Science Series, Alain Tressaud, 978-0-12-803740-9. ⟨10.1016/B978-0-12-803740-9.09001-6⟩ Ouvrages hal-02142647v1

Chapitre d'ouvrage (4)

Modern Fluorine‐Containing Agrochemicals Sergii Pazenok,David Bernier,Morgan Donnard,Gilles Hanquet,Armen Panossianet al. Z. Rappoport. PATAI'S Chemistry of Functional Groups, 1, Wiley; Wiley, 2022, 9780470682531. ⟨10.1002/9780470682531.pat1013⟩ Chapitre d'ouvrage hal-03920395v1
Enantioselective Catalysis by Nonmetal Frustrated Lewis Pairs Armen Panossian,Julien Bortoluzzi,Frédéric Leroux Topics in Enantioselective Catalysis, 09, WORLD SCIENTIFIC, pp.123-159, 2022, Series on Chemistry, Energy and the Environment, ⟨10.1142/9789811248436_0005⟩ Chapitre d'ouvrage hal-04171426v1
Modern Fluorine-Containing Agrochemicals Sergii Pazenok,Frédéric Leroux Frontiers of Organofluorine Chemistry, WORLD SCIENTIFIC (EUROPE), pp.695-732, 2020, ⟨10.1142/9781786347336_0016⟩ Chapitre d'ouvrage hal-03940952v1
Rapport de Conjoncture du CoNRS 2014 (INC / Section 12) Chantal Andraud,Philippe Belmont,J.M. Campagne,Gaëlle Chouraqui,Emmanuel Graset al. CNRS Editions, Paris,. Rapport de Conjoncture du CoNRS 2014, CNRS Editions, Paris,, pp.255-274, 2014, 978-2-271-08746-1 Chapitre d'ouvrage hal-02338362v1