Frédéric Leroux

114
Documents

Présentation

Frederic Leroux obtained a PhD in chemistry at the University of Konstanz (Germany), under the supervision of Prof. H. Fischer. In 1998, he moved to a postdoctoral position with Prof. M. Schlosser at the University of Lausanne (Switzerland) and accepted the same year a position of Assistant Professor. In 2001 he moved then to the Swiss Federal Institute of Technology in Lausanne (EPFL). He started his independent research career in 2003 as CNRS Research Associate at the University of Strasbourg (France). He obtained his habilitation in 2005 and was promoted CNRS Research Director in 2009.

Frederic Leroux is presently the director of the molecular chemistry department “Laboratoire d’Innovation Moléculaire et Applications” UMR CNRS 7042-LIMA of the Université de Strasbourg, Université de Haute-Alsace and the CNRS (lima.unistra.fr) and director of the joint CNRS-Bayer-Université de Strasbourg laboratory on organofluorine chemistry.

His research (coha.unistra.fr) is published in >120 peer-reviewed publications, 18 patents, 11 books and book chapters and presented by invitation at >80 (inter)national conferences. He is Fellow of the Royal Society of Chemistry (FRSC) and member of the European Academy of Sciences and Arts. He is also a member of the International Scientific Committee of the Moissan Prize (Fluorine Chemistry), Director of the French Fluorine Network (http://www.reseau-fluor.fr) and President of the French-Japanese Society of Medicinal and Fine Chemistry (fjs.crihan.fr).

The philosophy of his research is based on a fruitful interplay of several objectives (a) the synthesis of biologically relevant molecules, (b) asymmetric methodologies using organic and organometallic chemistry, (c) organofluorine chemistry and (d) application of the objectives to industrial problems, which led to strong industrial collaborations. The discovery of new and mild methodologies to introduce fluorine atoms or emergent fluorinated groups (OCF3, CHF2, ...) onto heterocycles as well as their stereoselective introduction onto Csp3-centers is a key topic of his research and developed in close collaboration with industry.

Publications

Publications

Image document

Phenylseleno trifluoromethoxylation of alkenes

Clément Delobel , Armen Panossian , Gilles Hanquet , Frédéric R Leroux , Fabien Toulgoat et al.
Beilstein Journal of Organic Chemistry, 2024, 20, pp.2434-2441. ⟨10.3762/bjoc.20.207⟩
Article dans une revue hal-04711420 v1
Image document

Unlocking the Power of Acyl Fluorides: A Comprehensive Guide to Synthesis and Properties

Clémence Bonnefoy , Adrien Gallego , Clément Delobel , Betty Raynal , Maxime Decourt et al.
European Journal of Organic Chemistry, 2024, 27 (18), pp.e202400142. ⟨10.1002/ejoc.202400142⟩
Article dans une revue hal-04591439 v1
Image document

Direct Introduction of the 1‐Fluorocyclopropyl Group <i>via</i> Stille Cross‐Coupling – A Way of Getting Around Per‐ and Polyfluoroalkyl Substances (PFASs)

Florian Audet , Morgan Donnard , Armen Panossian , Philipp M Holstein , David Bernier et al.
Advanced Synthesis and Catalysis, 2024, ⟨10.1002/adsc.202400401⟩
Article dans une revue hal-04655162 v1
Image document

3‐Amido‐benzo[b]silines: straightforward modular 2‐step synthesis and photophysical properties

Stéphane Golling , Tiahong Yan , Valérie Mazan , Frederic R. Leroux , Ilaria Ciofini et al.
Advanced Synthesis and Catalysis, In press, ⟨10.1002/adsc.202400293⟩
Article dans une revue hal-04538289 v1
Image document

Trifluoromethoxylation of Arynes using 2,4‐Dinitro‐1‐(trifluoromethoxybenzene) as Trifluoromethoxide Anion Source

Lilian Wisson , Gilles Hanquet , Fabien Toulgoat , Thierry Billard , Armen Panossian et al.
European Journal of Organic Chemistry, In press, 27 (28), pp.e202400388. ⟨10.1002/ejoc.202400388⟩
Article dans une revue hal-04591124 v1
Image document

Synthesis of 2-amidoindenone derivatives through an ynamide carbosilylation / Houben-Hoesch cyclization 2-step sequence

Pierre Hansjacob , Célia Schwoerer , Frédéric R Leroux , Morgan Donnard
Organic & Biomolecular Chemistry, 2024, 22, pp.70-73. ⟨10.1039/D3OB01787G⟩
Article dans une revue hal-04316905 v1
Image document

Synthesis of Polyfluoroalkyl Aryl Ethers Mediated by Sulfuryl Fluoride as a Traceless Activator

Clotilde Plaçais , Lilian Wisson , Isabelle Chataigner , Morgan Donnard , Armen Panossian et al.
Organic Letters, 2024, 26 (46), pp.10046-10050. ⟨10.1021/acs.orglett.4c03989⟩
Article dans une revue hal-04804896 v1
Image document

On a seamlessly replicable circular photoreactor for lab-scale continuous flow applications

Yi-Hsuan Tsai , Martin Cattoen , Guillaume Masson , Gabrielle Christen , Lisa Traber et al.
Reaction Chemistry & Engineering, In press, ⟨10.1039/D4RE00109E⟩
Article dans une revue hal-04558234 v1
Image document

Traceless N ‐Polyfluoroalkylation of Weakly Nucleophilic Nitrogen Containing Compounds

Laura Santos , Florian Audet , Morgan Donnard , Armen Panossian , Jean‐pierre Vors et al.
Chemistry - A European Journal, 2023, ⟨10.1002/chem.202300792⟩
Article dans une revue hal-04100627 v1
Image document

Zinc-Catalyzed Hydrocyanation of Ynamides and Photoisomerization, a General and Selective Access to E and Z Trisubstituted Alpha-Enamidonitriles

Pierre Hansjacob , Frédéric R Leroux , Morgan Donnard
Chemistry - A European Journal, 2023, pp.e202300120. ⟨10.1002/chem.202300120⟩
Article dans une revue hal-04051662 v1
Image document

Comprehensive Study and Development of a Metal-Free and Mild Nucleophilic Trifluoromethoxylation

Clémence Bonnefoy , Armen Panossian , Gilles Hanquet , Frédéric Leroux , Fabien Toulgoat et al.
Chemistry - A European Journal, 2023, 29 (46), ⟨10.1002/chem.202301513⟩
Article dans une revue hal-04165325 v1
Image document

Ruthenium‐catalyzed Synthesis of Aryl and Alkenyl Halides from Fluorosulfonates

Clotilde Plaçais , Sherif J. Kaldas , Morgan Donnard , Armen Panossian , David Bernier et al.
Chemistry - A European Journal, 2023, ⟨10.1002/chem.202301420⟩
Article dans une revue hal-04100620 v1
Image document

(NHC-olefin)-nickel(0) nanoparticles as catalysts for the (Z)-selective semi-hydrogenation of alkynes and ynamides

Marta G. Avello , Stéphane Golling , Lai Truong-Phuoc , Loic Vidal , Thierry Romero et al.
Chemical Communications, 2023, 59, pp.1537. ⟨10.1039/D2CC05302K⟩
Article dans une revue hal-03909675 v2
Image document

Direct Deprotonative Functionalization of α,α‐Difluoromethyl Ketones using a Catalytic Organosuperbase

Amélia Messara , Armen Panossian , Koichi Mikami , Gilles Hanquet , Frederic Leroux
Angewandte Chemie International Edition, In press, ⟨10.1002/anie.202215899⟩
Article dans une revue hal-03933942 v1
Image document

Exploring F/CF3 substituted oxocarbenium ions for the diastereoselective assembly of highly substituted tetrahydrofurans

Anthony J Fernandes , Bastien Michelet , Armen Panossian , Agnès Martin-Mingot , Frédéric R Leroux et al.
Chemical Communications, 2023, 59 (27), pp.4083-4086. ⟨10.1039/d2cc06521e⟩
Article dans une revue hal-04046996 v1
Image document

Reactions of substituted arynes and diphenylphosphine oxide or diphenylphosphine-borane complex toward dibenzophospholes – impact of aryne substituents

Marie-Charlotte Belhomme , Thomas Guérin , Armen Panossian , Frédéric R Leroux
Phosphorus, Sulfur, and Silicon and the Related Elements, 2023, 198, ⟨10.1080/10426507.2023.2168270⟩
Article dans une revue hal-04057602 v1
Image document

New Chemical Transformations Involving SO 2 F 2 ‐Mediated Alcohol Activation

Florian Audet , Morgan Donnard , Armen Panossian , David Bernier , Sergii Pazenok et al.
Chemical Record, In press, ⟨10.1002/tcr.202300107⟩
Article dans une revue hal-04164625 v1
Image document

Difluoromethoxylated Ketones as Building Blocks for the Synthesis of Challenging OCF2H‐Bearing N‐Heterocycles.

Anaïs Loison , Gilles Hanquet , Fabien Toulgoat , Thierry Billard , Armen Panossian et al.
European Journal of Organic Chemistry, 2023, 26 (42), pp.e202300695. ⟨10.1002/ejoc.202300695⟩
Article dans une revue hal-04163739 v2
Image document

Palladium‐Catalyzed Silylcyanation of Ynamides: Regio‐ and Stereoselective Access to Tetrasubstituted 3‐Silyl‐2‐Aminoacrylonitriles

Pierre Hansjacob , Frédéric R. Leroux , Vincent Gandon , Morgan Donnard
Angewandte Chemie International Edition, 2022, ⟨10.1002/anie.202200204⟩
Article dans une revue hal-03541070 v1
Image document

Study of Carbamoyl Fluoride: Synthesis, Properties and Applications

Clémence Bonnefoy , Emmanuel Chefdeville , Christian Tourvieille , Armen Panossian , Gilles Hanquet et al.
Chemistry - A European Journal, 2022, 28 (43), ⟨10.1002/chem.202201589⟩
Article dans une revue hal-03744602 v1
Image document

One‐step Oxidative Monofluorination of Electron‐deficient Sulfoxides to Access Highly Lewis Acidic Sulfur(VI) Cations

Jordan Berreur , Alberto Diez-Varga , Augustin Manel , Frédéric Leroux , Armen Panossian
Chemistry - A European Journal, 2022, ⟨10.1002/chem.202202564⟩
Article dans une revue hal-03795951 v1
Image document

Ketenimines as Intermediates To Access Difluoromethoxylated Scaffolds

Anaïs Loison , Gilles Hanquet , Fabien Toulgoat , Thierry Billard , Armen Panossian et al.
Organic Letters, 2022, ⟨10.1021/acs.orglett.2c03283⟩
Article dans une revue hal-03843401 v1
Image document

Direct Access to 2,3-Disubstituted Amido-Indenones through Annulation of 2-Iodobenzaldehydes with Ynamides

Stéphane Golling , Pierre Hansjacob , Nassim Bami , Frédéric R Leroux , Morgan Donnard
Journal of Organic Chemistry, 2022, ⟨10.1021/acs.joc.2c02054⟩
Article dans une revue hal-03883448 v1
Image document

SO2F2-Mediated N-Alkylation of Imino-Thiazolidinones

Laura Santos , Morgan Donnard , Armen Panossian , Jean-Pierre Vors , Peter Jeschke et al.
Journal of Organic Chemistry, In press, ⟨10.1021/acs.joc.1c01247⟩
Article dans une revue hal-03325274 v1
Image document

Recent synthetic methods towards the –OCHF2 moiety

Anaïs Loison , Fabien Toulgoat , Thierry Billard , Gilles Hanquet , Armen Panossian et al.
Tetrahedron, 2021, 99, pp.132458. ⟨10.1016/j.tet.2021.132458⟩
Article dans une revue hal-03517915 v1
Image document

CF3-substituted carbocations: underexploited intermediates with great potential in modern synthetic chemistry

Anthony J Fernandes , Armen Panossian , Bastien Michelet , Agnès Martin-Mingot , Frédéric Leroux et al.
Beilstein Journal of Organic Chemistry, 2021, 17, pp.343-378. ⟨10.3762/bjoc.17.32⟩
Article dans une revue hal-03154651 v1
Image document

Electrophilic fluorosulfoxonium cations as hidden Brønsted acid catalysts in (n+2) annulations of strained cycloalkanes

Augustin Manel , Jordan Berreur , Frédéric R. Leroux , Armen Panossian
Organic Chemistry Frontiers, In press, ⟨10.1039/D1QO00840D⟩
Article dans une revue hal-03325336 v1
Image document

Direct trifluoromethoxylation without OCF3 ‐carrier via in‐situ generation of fluorophosgene

Jérémy Saiter , Thomas Guérin , Morgan Donnard , Armen Panossian , Gilles Hanquet et al.
European Journal of Organic Chemistry, 2021, 2021 (22), ⟨10.1002/ejoc.202100429⟩
Article dans une revue hal-03228836 v1
Image document

Versatile Access to Tetrasubstituted 2-Amidoacroleins through Formal Silylformylation of Ynamides

Stéphane Golling , Frédéric R. Leroux , Morgan Donnard
Organic Letters, 2021, 23, pp.8093-8097. ⟨10.1021/acs.orglett.1c03141⟩
Article dans une revue hal-03369636 v1
Image document

The winding road towards an atropo-enantioselective 'ARYNE coupling

David Augros , Corinne Comoy , Yves Fort , Frédéric Leroux , Armen Panossian
European Journal of Organic Chemistry, 2021, ⟨10.1002/ejoc.202100087⟩
Article dans une revue hal-03170152 v1
Image document

Study of a Stable “Trifluoromethoxide Anion Solution” Arising from 2,4‐Dinitro‐Trifluoromethoxybenzene

Clémence Bonnefoy , Emmanuel Chefdeville , Armen Panossian , Gilles Hanquet , Frédéric R. Leroux et al.
Chemistry - A European Journal, 2021, 27 (64), pp.15986-15991. ⟨10.1002/chem.202102809⟩
Article dans une revue hal-03582991 v1
Image document

Practical Synthesis and Application of Halogen-Doped Pyrrole Building Blocks

Andrej Emanuel Cotman , Thomas Guérin , Ivana Kovačević , Davide Benedetto Tiz , Martina Durcik et al.
ACS Omega, 2021, 6 (14), pp.9723-9730. ⟨10.1021/acsomega.1c00331⟩
Article dans une revue hal-03228819 v1
Image document

Aryl Fluoroalkyl Sulfoxides: Optical Stability and p K a Measurement

Amélia Messara , Nicolas Vanthuyne , Patrick Diter , Mourad Elhabiri , Armen Panossian et al.
European Journal of Organic Chemistry, 2021, 2021 (36), ⟨10.1002/ejoc.202100816⟩
Article dans une revue hal-03319682 v1
Image document

Synthesis of 3-Amino-5-fluoroalkylfurans by Intramolecular Cyclization

Clotilde Plaçais , Morgan Donnard , Armen Panossian , Jean-Pierre Vors , David Bernier et al.
Organic Letters, 2021, 23 (12), pp.4915-4919. ⟨10.1021/acs.orglett.1c01672⟩
Article dans une revue hal-03325240 v1
Image document

Formation of synthetically relevant CF3-substituted phenonium ions in superacid media

Anthony J Fernandes , Bastien Michelet , Armen Panossian , Agnès Martin-Mingot , Frédéric R. Leroux et al.
RSC Advances, 2021, 11 (41), pp.25695 - 25699. ⟨10.1039/d1ra04901a⟩
Article dans une revue hal-03325280 v1
Image document

Deprotonative Functionalization of the Difluoromethyl Group

Laura Santos , Armen Panossian , Morgan Donnard , Jean-Pierre Vors , Sergii Pazenok et al.
Organic Letters, 2020, ⟨10.1021/acs.orglett.0c03380⟩
Article dans une revue hal-02989088 v1
Image document

Synthesis and Use of Trifluoromethylthiolated Ketenimines

Frédéric R. Leroux , Thomas Guérin , Nadiia Pikun , Ryutaro Morioka , Armen Panossian et al.
Chemistry - A European Journal, 2020, ⟨10.1002/chem.202002723⟩
Article dans une revue hal-02990038 v1
Image document

Transition-Metal-Free Heterobiaryl Synthesis via Aryne Coupling

Tarak Saied , Catherine Demangeat , Armen Panossian , Frédéric Leroux , Yves Fort et al.
European Journal of Organic Chemistry, 2019, 2019 (31-32), pp.5275-5284. ⟨10.1002/ejoc.201900130⟩
Article dans une revue hal-02186792 v1
Image document

Efficient asymmetric synthesis of aryl difluoromethyl sulfoxides and their use to access enantiopure α-difluoromethyl alcohols

Chloé Batisse , Maria Cespedes Davila , Marco Castello , Amélia Messara , Bertrand Vivet et al.
Tetrahedron, 2019, 75 (23), pp.3063-3079. ⟨10.1016/j.tet.2019.04.037⟩
Article dans une revue hal-02400108 v1

Transition-Metal-Free Approach for the Direct Arylation of Thiophene: Experimental and Theoretical Investigations towards the (Het)-Aryne Route

Catherine Demangeat , Tarak Saied , Romain Ramozzi , Francesca Ingrosso , Manuel Ruiz-Lopez et al.
European Journal of Organic Chemistry, 2019, 2019 (2-3), pp.547-556. ⟨10.1002/ejoc.201801173⟩
Article dans une revue hal-02186820 v1

A physico-chemical investigation of fluorine-enriched quinolines

F. Aribi , A. Panossian , Denis Jacquemin , J.-P. Vors , S. Pazenok et al.
New Journal of Chemistry, 2018, 42 (12), pp.10036-10047. ⟨10.1039/c8nj00916c⟩
Article dans une revue hal-02105499 v1

Stereoselectivity Switch in the Trapping of Polar Organometallics with Andersen’s Reagent—Access to Highly Stereoenriched Transformable Biphenyls

J. Bortoluzzi , V. Jha , G. Levitre , M. J. Fer , J. Berreur et al.
Journal of Organic Chemistry, 2018, 83 (15), pp.7751-7761. ⟨10.1021/acs.joc.8b00648⟩
Article dans une revue hal-02105503 v1

A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation

T. Naret , J. Bignon , G. Bernadat , M. Benchekroun , H. Levaique et al.
European Journal of Medicinal Chemistry, 2018, 143, pp.473-490. ⟨10.1016/j.ejmech.2017.11.055⟩
Article dans une revue hal-02105508 v1
Image document

Access towards enantiopure α,α-difluoromethyl alcohols by means of sulfoxides as traceless chiral auxiliaries

Chloé Batisse , Armen Panossian , Gilles Hanquet , Frédéric Leroux
Chemical Communications, 2018, 54 (74), pp.10423-10426. ⟨10.1039/C8CC05571H⟩
Article dans une revue hal-02150060 v1
Image document

Synthesis of Mono- and Bis(fluoroalkyl)pyrimidines from FARs, Fluorinated Acetoacetates, and Malononitrile Provides Easy Access to Novel High-Value Pyrimidine Scaffolds

E. Schmitt , B. Commare , A. Panossian , J.-P. Vors , S. Pazenok et al.
Chemistry - A European Journal, 2018, 24 (6), pp.1311-1316. ⟨10.1002/chem.201703982⟩
Article dans une revue hal-02105509 v1

Towards biphenyl based frustrated Lewis pairs

Julien Bortoluzzi , Frédéric Leroux , Armen Panossian
Abstracts of Papers of the American Chemical Society, 2018, 256
Article dans une revue hal-04889950 v1
Image document

Fluoroalkyl Amino Reagents for the Introduction of the Fluoro(trifluoromethoxy)methyl Group onto Arenes and Heterocycles

Etienne Schmitt , Sebastien Bouvet , Bruce Pegot , Armen Panossian , Jean-Pierre Vors et al.
Organic Letters, 2017, 19 (18), pp.4960-4963. ⟨10.1021/acs.orglett.7b02444⟩
Article dans une revue hal-02105321 v1
Image document

Control of axial chirality in absence of transition metals based on arynes

Frédéric R. Leroux , Armen Panossian , David Augros
Comptes Rendus. Chimie, 2017, 20 (6), pp.682-692. ⟨10.1016/j.crci.2016.12.001⟩
Article dans une revue hal-02105315 v1

Switchable Diastereoselectivity in the Fluoride-Promoted Vinylogous Mukaiyama–Michael Reaction of 2-[(Trimethylsilyl)oxy]furan Catalyzed by Crown Ethers

Giorgio Della Sala , Marina Sicignano , Rosaria Schettini , Francesco de Riccardis , Luigi Cavallo et al.
Journal of Organic Chemistry, 2017, 82 (13), pp.6629-6637. ⟨10.1021/acs.joc.7b00743⟩
Article dans une revue hal-02105791 v1
Image document

Fluoroalkyl Amino Reagents (FARs): A General Approach towards the Synthesis of Heterocyclic Compounds Bearing Emergent Fluorinated Substituents

Bruno Commare , Etienne Schmitt , Fallia Aribi , Armen Panossian , Jean-Pierre Vors et al.
Molecules, 2017, 22 (6), pp.977. ⟨10.3390/molecules22060977⟩
Article dans une revue hal-02105792 v1

Le fluor, un élément qui vous veut du bien

Frédéric Leroux
L'Actualité Chimique, 2017, 421
Article dans une revue hal-05020031 v1
Image document

Tri- and difluoromethoxylated N-based heterocycles − Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid

Grégory Landelle , Etienne Schmitt , Armen Panossian , Jean-Pierre Vors , Sergiy Pazenok et al.
Journal of Fluorine Chemistry, 2017, 203, pp.155-165. ⟨10.1016/j.jfluchem.2017.08.006⟩
Article dans une revue hal-02105310 v1
Image document

Transition-Metal-Free Synthesis of a Known Intermediate in the Formal Synthesis of (-)-Steganacin

David Augros , Boubacar Yalcouye , Sabine Choppin , Matthieu Chessé , Armen Panossian et al.
European Journal of Organic Chemistry, 2017, 2017 (3), pp.497-503. ⟨10.1002/ejoc.201601239⟩
Article dans une revue hal-02105793 v1

Asymmetric α-Sulfonyl- and α-Phosphoryl-Oxylation of Ketones by a Chiral Hypervalent Iodine(III)

Guillaume Levitre , Audrey Dumoulin , Pascal Retailleau , Armen Panossian , Frederic R. Leroux et al.
Journal of Organic Chemistry, 2017, 82 (22), pp.11877-11883. ⟨10.1021/acs.joc.7b01597⟩
Article dans une revue hal-02105318 v1

When Chirality Meets “Buchwald-Type” Phosphines: Synthesis and Evaluation in Frustrated Lewis Pair-, Lewis Base- and Palladium-Promoted Asymmetric Catalysis

Frédéric R. Leroux , Mickaël Fer , Joséphine Cinqualbre , Julien Bortoluzzi , Matthieu Chessé et al.
European Journal of Organic Chemistry, 2016, 2016 (26), pp.4545-4553. ⟨10.1002/ejoc.201600727⟩
Article dans une revue istex hal-03004119 v1
Image document

A Major Advance in the Synthesis of Fluoroalkyl Pyrazoles: Tuneable Regioselectivity and Broad Substitution Patterns

Etienne Schmitt , Armen Panossian , Jean-Pierre Vors , Christian Funke , Norbert Lui et al.
Chemistry - A European Journal, 2016, 22 (32), pp.11239-11244. ⟨10.1002/chem.201601621⟩
Article dans une revue hal-03004108 v1
Image document

A new approach toward the synthesis of 2,4-bis(fluoroalkyl)-substituted quinoline derivatives using fluoroalkyl amino reagent chemistry

Fallia Aribi , Etienne Schmitt , Armen Panossian , Jean-Pierre Vors , Sergiy Pazenok et al.
Organic Chemistry Frontiers, 2016, 3 (11), pp.1392-1415. ⟨10.1039/C6QO00319B⟩
Article dans une revue hal-03004130 v1

Access to Atropisomerically Enriched Biaryls by the Coupling of Aryllithiums with Arynes under Control by Homochiral Oxazolines

Boubacar Yalcouye , Anaïs Brehier , David Augros , Armen Panossian , Sabine Choppin et al.
European Journal of Organic Chemistry, 2016, 2016 (4), pp.725-732. ⟨10.1002/ejoc.201501503⟩
Article dans une revue istex hal-02304102 v1

Atropo-diastereoselective coupling of aryllithiums and arynes — variations around the chiral auxiliary

Frédéric R. Leroux , David Augros , Boubacar Yalcouye , Anaïs Berthelot-Bréhier , Matthieu Chessé et al.
Tetrahedron, 2016, 72 (34), pp.5208-5220. ⟨10.1016/j.tet.2016.01.047⟩
Article dans une revue hal-03004140 v1

Lithium/Element Exchange as an Efficient Tool for Accessing Atropo-enriched Biaryls <i>via</i> Arynes

Armen Panossian , Frédéric Leroux
CHIMIA, 2016, 70 (1), pp.43-47. ⟨10.2533/chimia.2016.43⟩
Article dans une revue hal-03004175 v1

The French Connection : Editorial

Frédéric R. Leroux
CHIMIA, 2016, 70 (1-2), pp.6-7
Article dans une revue hal-04876344 v1

In Situ Generated Fluorinated Iminium Salts for Difluoromethylation and Difluoroacetylation

Frédéric R. Leroux , Etienne Schmitt , Baptiste Rugeri , Armen Panossian , Jean-Pierre Vors et al.
Organic Letters, 2015, 17 (18), pp.4510-4513. ⟨10.1021/acs.orglett.5b02184⟩
Article dans une revue hal-03004193 v1

Determination of the absolute configuration of phosphinic analogues of glutamate

Bruno Commare , Delphine Rigault , Isabelle Lemasson , Patrick Deschamps , Alain Tomas et al.
Organic & Biomolecular Chemistry, 2015, 13 (4), pp.1106-1112. ⟨10.1039/C4OB01960A⟩
Article dans une revue hal-02268872 v1

Recent advances and new concepts for the synthesis of axially stereoenriched biaryls

Joanna Wencel‐delord , Armen Panossian , Frédéric Leroux , Françoise Colobert
Chemical Society Reviews, In press, ⟨10.1039/c5cs00012b⟩
Article dans une revue hal-02305225 v1

Modular Synthesis of Biaryl-Substituted Phosphine Ligands: Application in Microwave-Assisted Palladium-Catalyzed C-N Cross-Coupling Reactions

Chandani Singh , Jayant Rathod , Vishwajeet Jha , Armen Panossian , Pradeep Kumar et al.
European Journal of Organic Chemistry, 2015, 2015 (29), pp.6515-6525. ⟨10.1002/ejoc.201500962⟩
Article dans une revue istex hal-02304103 v1
Image document

Substituent effects on the relative rates and free energies of ortho-lithiation reactions: families of fluorobenzenes as the substrates

F Mongin , C Curty , E Marzi , Frédéric Leroux , M Schlosser
ARKIVOC - Online Journal of Organic Chemistry, 2015, 4, pp.48-65. ⟨10.3998/ark.5550190.p008.926⟩
Article dans une revue hal-02304104 v1

Unusual phosphine oxidation: new triazolopyridyl-quinolyl phosphine oxide fluorescent dyes

R. Ballesteros-Garrido , B. Abarca , R. Ballesteros , F. Colobert , Frédéric R. Leroux et al.
RSC Advances, 2015, 5 (38), pp.29809-29813. ⟨10.1039/C5RA04386G⟩
Article dans une revue hal-03004215 v1

Atroposelective synthesis of axially chiral P,S-ligands based on arynes

Anais Berthelot-Brehier , Armen Panossian , Francoise Colobert-Leuenberger , Frédéric Leroux
Organic Chemistry Frontiers, 2015, 2 (6), pp.634-644. ⟨10.1039/C5QO00067J⟩
Article dans une revue hal-02306240 v1

Synthesis and biological evaluation of new nucleosides derived from trifluoromethoxy-4-quinolones

Kristína Plevová , Katarína Briestenská , Francoise Colobert-Leuenberger , Jela Mistríková , Viktor Milata et al.
Tetrahedron Letters, 2015, 56 (36), pp.5112-5115. ⟨10.1016/j.tetlet.2015.07.031⟩
Article dans une revue hal-02305222 v1

Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands

Frédéric R. Leroux , Julien Graff , Elżbieta Łastawiecka , Laure Guénée , Frédéric Leroux et al.
Advanced Synthesis and Catalysis, 2015, 357 (13), pp.2833-2839. ⟨10.1002/adsc.201500323⟩
Article dans une revue istex hal-03004211 v1

Tribute to Prof. Manfred Schlosser (1934-2013) Obituary

Renzo Ruzziconi , Frédéric Leroux
Journal of Fluorine Chemistry, 2015, 171, pp.2-3. ⟨10.1016/j.jfluchem.2014.09.014⟩
Article dans une revue hal-02304109 v1

Multi-nuclear NMR of axially chiral biaryls in polypeptide orienting solvents: spectral discriminations and enantiorecognition mechanisms

Philippe Berdagué , Jose-Enrique Herbert-Pucheta , Vishwajeet Jha , Armen Panossian , Frédéric Leroux et al.
New Journal of Chemistry, 2015, 39 (12), pp.9504-9517. ⟨10.1039/c5nj01434d⟩
Article dans une revue hal-02314357 v1

A General Approach towards NH-Pyrazoles That Bear Diverse Fluoroalkyl Groups by Means of Fluorinated Iminium Salts

Étienne Schmitt , Gregory Landelle , Jean-Pierre Vors , Norbert Lui , Sergiy Pazenok et al.
European Journal of Organic Chemistry, 2015, 27, pp.6052-6060. ⟨10.1002/ejoc.201500920⟩
Article dans une revue istex hal-02305226 v1

Fluorine Chemistry Special Feature

Frédéric Leroux , Mark Ford , Sergiy Pazenok
Organic Process Research and Development, 2014, 18 (8), ⟨10.1021/op500216s⟩
Article dans une revue hal-02306238 v1

Trifluoromethyl Ethers and -Thioethers as Tools for Medicinal Chemistry and Drug Discovery

Gregory Landelle , Armen Panossian , Frédéric Leroux
Current Topics in Medicinal Chemistry, 2014, 14 (7), pp.941-951
Article dans une revue hal-02306242 v1

Novel C1-symmetric dibenzophosphole ligands: application in hydroformylation reactions

Abdelouahd Oukhrib , Laurence Bonnafoux , Armen Panossian , Sandrine Waifang , Duc Hanh Nguyen et al.
Tetrahedron, 2014, 70 (7), pp.1431-1436. ⟨10.1016/j.tet.2014.01.003⟩
Article dans une revue hal-00992450 v1

A theoretical and experimental study of the racemization process of hexaaza[5]helicenes

Belen Abarca , Rafael Ballesteros , Rosa Adam , Rafael Ballesteros-Garrido , Frédéric Leroux et al.
Tetrahedron, 2014, 70 (45), pp.8750-8757. ⟨10.1016/j.tet.2014.09.018⟩
Article dans une revue hal-02307797 v1

A concise atroposelective formal synthesis of (-)-steganone

Boubacar Yalcouye , Sabine Choppin , Armen Panossian , Frédéric Leroux , Francoise Colobert-Leuenberger
European Journal of Organic Chemistry, 2014, 2014 (28), pp.6285-6294. ⟨10.1002/ejoc.201402761⟩
Article dans une revue istex hal-02304105 v1

A New Synthesis and Process Development of Bis(fluoroalkyl)pyrazoles As Novel Agrophores

F Giornal , G Landelle , N Lui , J Vors , S Pazenok et al.
Organic Process Research and Development, 2014, 18 (8), pp.1002-1009. ⟨10.1021/Op500102h⟩
Article dans une revue hal-02342504 v1

Recent advances in transition metal-catalyzed Csp(2)-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

Gregory Landelle , Armen Panossian , Sergiy Pazenok , Jean-Pierre Vors , Frédéric Leroux
Beilstein Journal of Organic Chemistry, 2013, 9, pp.2476-2536. ⟨10.3762/bjoc.9.287⟩
Article dans une revue hal-02304098 v1

Convenient and Reliable Routes Towards 2-Aminothiazoles: Palladium-Catalyzed versus Copper-Catalyzed Aminations of Halothiazoles

Stéphanie Toulot , Timo Heinrich , Frédéric Leroux
Advanced Synthesis and Catalysis, 2013, 355 (16), pp.3263-3272. ⟨10.1002/adsc.201300591⟩
Article dans une revue hal-02342506 v1

Manfred Schlosser (1934-2013) Obituary

Frédéric Leroux
Angewandte Chemie International Edition, 2013, 52 (48), ⟨10.1002/anie.201308231⟩
Article dans une revue istex hal-02307800 v1

A New Life for an Old Reagent: Fluoroalkyl Amino Reagents as Efficient Tools for the Synthesis of Diversely Fluorinated Pyrazoles

Sergiy Pazenok , Florence Giornal , Grégory Landelle , Norbert Lui , Jean-Pierre Vors et al.
European Journal of Organic Chemistry, 2013, 2013 (20), pp.4249-4253. ⟨10.1002/ejoc.201300561⟩
Article dans une revue istex hal-03004227 v1

Synthesis and structural properties of hexaaza[5]helicene containing two [1,2,3]triazolo[1,5-a]pyridine moieties

Rosa Adam , Rafael Ballesteros-Garrido , Oriol Vallcorba , Belen Abarca , Rafael Ballesteros et al.
Tetrahedron Letters, 2013, 54 (32), pp.4316-4319. ⟨10.1016/j.tetlet.2013.06.014⟩
Article dans une revue istex hal-02306243 v1

Palladium-Catalyzed Intramolecular Direct Arylation of 2-Bromo-diaryl Sulfoxides via C-H Bond Activation

Thomas Wesch , Anaïs Brehier , Frédéric Leroux , Francoise Colobert-Leuenberger
Organic Letters, 2013, 15 (10), pp.2490-2493. ⟨10.1021/ol400966q⟩
Article dans une revue hal-02304107 v1

Atropodiastereoselective C-H Olefination of Biphenyl p-Tolyl Sulfoxides with Acrylates

Thomas Wesch , Frédéric Leroux , Francoise Colobert-Leuenberger
Advanced Synthesis and Catalysis, 2013, 355 (11-12), pp.2139-2144. ⟨10.1002/adsc.201300446⟩
Article dans une revue istex hal-02304106 v1

Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients

Florence Giornal , Lars Rodefeld , Norbert Lui , Jean-Pierre Vors , Frédéric Leroux
Journal of Fluorine Chemistry, 2013, 152, pp.2-11. ⟨10.1016/j.jfluchem.2012.11.008⟩
Article dans une revue istex hal-02307799 v1

Aryne-mediated fluorination: Synthesis of fluorinated biaryls via a sequential desilylation-halide elimination-fluoride addition process

Vincent Diemer , Juan Garcia , Frédéric Leroux , Francoise Colobert-Leuenberger
Journal of Fluorine Chemistry, 2012, 134, pp.146-155. ⟨10.1016/j.jfluchem.2011.02.017⟩
Article dans une revue istex hal-02306231 v1

Triazolopyridines. Part 28. The ring-chain isomerization strategy: triazolopyridine- and triazoloquinoline-pyridine based fluorescence ligands

Rafael Ballesteros-Garrido , Estefania Delgado-Pinar , Belen Abarca , Rafael Ballesteros , Frédéric Leroux et al.
Tetrahedron, 2012, 68 (19), pp.3701-3707. ⟨10.1016/j.tet.2012.03.029⟩
Article dans une revue istex hal-02306237 v1

Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki-Miyaura coupling

Timo Leermann , Pierre-Emmanuel Broutin , Frédéric Leroux , Francoise Colobert-Leuenberger
Organic & Biomolecular Chemistry, 2012, 10 (20), pp.4095-4102. ⟨10.1039/c2ob25373a⟩
Article dans une revue hal-02306241 v1

Transition-Metal-Free Atropo-Selective Synthesis of Biaryl Compounds Based on Arynes

Frédéric Leroux , Anaïs Brehier , Laurence Bonnafoux , Armen Panossian , Francoise Colobert-Leuenberger
Chemistry - A European Journal, 2012, 18 (45), pp.14232-14236. ⟨10.1002/chem.201202739⟩
Article dans une revue istex hal-02306232 v1

Stereoselective Synthesis of o -Bromo (or Iodo)aryl P-Chirogenic Phosphines Based on Aryne Chemistry

Frédéric R. Leroux , Jérôme Bayardon , Hugo Laureano , Vincent Diemer , Mathieu Dutartre et al.
Journal of Organic Chemistry, 2012, 77 (13), pp.5759-5769. ⟨10.1021/jo300910w⟩
Article dans une revue hal-03004233 v1

Stereoselective Synthesis of P-Chirogenic Dibenzophosphole-Boranes via Aryne Intermediates

Vincent Diemer , Anaïs Brehier , Jérôme Bayardon , Sylvain Juge , Frédéric Leroux et al.
Journal of Organic Chemistry, 2012, 77 (14), pp.6117-6127. ⟨10.1021/jo3009098⟩
Article dans une revue hal-02306244 v1

Efficient and Complementary Methods Offering Access to Synthetically Valuable 1,2-Dibromobenzenes

Vincent Diemer , Frédéric Leroux , Francoise Colobert-Leuenberger
European Journal of Organic Chemistry, 2011, 2, pp.327-340. ⟨10.1002/ejoc.201001217⟩
Article dans une revue istex hal-02306234 v1

Polar Organometallic Chemistry

Frédéric Leroux
Current Organic Chemistry, 2011, 15 (13)
Article dans une revue hal-02305223 v1

Catalytic Palladium Phosphination: Modular Synthesis of C1-Symmetric Biaryl-Based Diphosphines

Laurence Bonnafoux , Rafael Gramage-Doria , Francoise Colobert , Frederic R. Leroux
Chemistry - A European Journal, 2011, 17 (39), pp.11008-11016. ⟨10.1002/chem.201101529⟩
Article dans une revue istex hal-01472931 v1

Bromine-lithium exchange: An efficient tool in the modular construction of biaryl ligands

Laurence Bonnafoux , Frédéric Leroux , Francoise Colobert-Leuenberger
Beilstein Journal of Organic Chemistry, 2011, 7, pp.1278-1287. ⟨10.3762/bjoc.7.148⟩
Article dans une revue hal-02307798 v1

Highly Efficient One-Pot Access to Functionalized Arylboronic Acids via Noncryogenic Bromine/Magnesium Exchanges

Timo Leermann , Frédéric Leroux , Francoise Colobert-Leuenberger
Organic Letters, 2011, 13 (17), pp.4479-4481. ⟨10.1021/ol2016252⟩
Article dans une revue hal-02305220 v1

Through-Space J(P,P) and J(P,F) Spin-Spin Coupling in C-1-Symmetric Biaryl Diphosphanes

Laurence Bonnafoux , Ludger Ernst , Frédéric Leroux , Francoise Colobert-Leuenberger
European Journal of Inorganic Chemistry, 2011, 22, pp.3387-3397. ⟨10.1002/ejic.201100428⟩
Article dans une revue istex hal-02306233 v1

Regioselectivity in the Aryne Cross-Coupling of Aryllithiums with Functionalized 1,2-Dibromobenzenes

Vincent Diemer , Manon Begaud , Frédéric Leroux , Francoise Colobert-Leuenberger
European Journal of Organic Chemistry, 2011, 2, pp.341-354. ⟨10.1002/ejoc.201001283⟩
Article dans une revue istex hal-02306235 v1

[1,2,3]Triazolo[1,5-a]pyridyl phosphines reflecting the influence of phosphorus lone pair orientation on spectroscopic properties

Rafael Ballesteros-Garrido , Laurence Bonnafoux , Fernando Blanco , Rafael Ballesteros , Frédéric Leroux et al.
Dalton Transactions, 2011, 40 (6), pp.1387-1395. ⟨10.1039/C0DT01183E⟩
Article dans une revue hal-02306239 v1

A General Approach to (Trifluoromethoxy)pyridines: First X-ray Structure Determinations and Quantum Chemistry Studies

Baptiste Manteau , Pierre Genix , Lydia Brelot , Jean-Pierre Vors , Sergiy Pazenok et al.
European Journal of Organic Chemistry, 2010, 2010 (31), pp.6043-6066. ⟨10.1002/ejoc.201000958⟩
Article dans une revue istex hal-03370334 v1

2,2′,6-Tribromobiphenyl via Transition-Metal-Free ARYNE Coupling: A Valuable Tool in the Synthesis of Biphenyls

Frédéric R. Leroux , Laurence Bonnafoux , Françoise Colobert
SYNLETT, 2010, 2010 (19), pp.2953-2955. ⟨10.1055/s-0030-1259025⟩
Article dans une revue hal-03366549 v1

Efficient synthesis of quaternary and P-stereogenic phosphonium triflates

Emmanuelle Remond , Arnaud Tessier , Frédéric Leroux , Jérome Bayardon , Sylvain Jugé
Organic Letters, 2010, 12 (7), pp.1568-1571. ⟨10.1021/ol100304c⟩
Article dans une revue hal-00474388 v1

Carbamoyl fluorides: from synthesis to radiochemistry

Clémence Bonnefoy , Emmanuel Chefdeville , Armen Panossian , Gilles Hanquet , Frédéric R. Leroux et al.
57th International Conference on Medicinal Chemistry, Jul 2023, Lille, France
Poster de conférence hal-04720307 v1

Carbamoyl Fluorides: From Synthesis to Radiochemistry

Clémence Bonnefoy , Emmanuel Chefdeville , Armen Panossian , Gilles Hanquet , Frédéric R. Leroux et al.
28th French-Japanese Symposium on Medicinal & Fine Chemistry, Oct 2023, Nice, France
Poster de conférence hal-04720313 v1

Carbamoyl fluoride as a potential new tag for fluorine-18 labeling

Clémence Bonnefoy , Christian Tourvieille , Armen Panossian , Gilles Hanquet , Frédéric R. Leroux et al.
24th International Symposium on Radiopharmaceutical Sciences, May 2022, Nantes, France
Poster de conférence hal-04720303 v1

2,4-Dinitro-trifluoromethoxybenzene: a promising reagent in fluorine chemistry

Clémence Bonnefoy , Emmanuel Chefdeville , Christian Tourvielle , Armen Panossian , Gilles Hanquet et al.
55th Bürgenstock Conference, May 2022, Brunnen, Switzerland
Poster de conférence hal-04720299 v1

Modern Fluorine‐Containing Agrochemicals

Sergii Pazenok , David Bernier , Morgan Donnard , Gilles Hanquet , Armen Panossian et al.
Z. Rappoport. PATAI'S Chemistry of Functional Groups, 1, Wiley; Wiley, 2022, 9780470682531. ⟨10.1002/9780470682531.pat1013⟩
Chapitre d'ouvrage hal-03920395 v1

Enantioselective Catalysis by Nonmetal Frustrated Lewis Pairs

Armen Panossian , Julien Bortoluzzi , Frédéric Leroux
Topics in Enantioselective Catalysis, 09, WORLD SCIENTIFIC, pp.123-159, 2022, Series on Chemistry, Energy and the Environment, ⟨10.1142/9789811248436_0005⟩
Chapitre d'ouvrage hal-04171426 v1

Modern Fluorine-Containing Agrochemicals

Sergii Pazenok , Frédéric Leroux
Frontiers of Organofluorine Chemistry, WORLD SCIENTIFIC (EUROPE), pp.695-732, 2020, ⟨10.1142/9781786347336_0016⟩
Chapitre d'ouvrage hal-03940952 v1

Rapport de Conjoncture du CoNRS 2014 (INC / Section 12)

Chantal Andraud , Philippe Belmont , J.M. Campagne , Gaëlle Chouraqui , Emmanuel Gras et al.
CNRS Editions, Paris,. Rapport de Conjoncture du CoNRS 2014, CNRS Editions, Paris,, pp.255-274, 2014, 978-2-271-08746-1
Chapitre d'ouvrage hal-02338362 v1