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Frédéric Rieux-Laucat

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Présentation

I am currently holding a position of Director of Research at the National Institute of Health and Medical Research (Inserm) and Group Leader of the laboratory “Immunogenetics of Pediatric Autoimmune Diseases” at Imagine Institute, Paris, France (private Research and Healthcare Institute located in the campus of Necker Hospital Campus). I am also sitting at the Board of Trustees as a Teaching and Research Representative and at the Executive Committee. In the recent past I was a member of at the Scientific Commission of the Arc Foundation, and I was a member of the Scientific Evaluation Committee of Pasteur Institute (COMESP). From 2012 to 2016 I was the president of the Specialized Scientific committee Immunology-Microbiology at INSERM. My research team is focusing on the mechanisms involved in the control of self-tolerance in primary human immunodeficiencies associated with early-onset autoimmunity. Our works aim to provide a better understanding of the molecular and cellular bases of the mechanisms involved in lymphocytes homeostasis and self-tolerance, and should allow the identification of susceptibility factors to human auto-immune diseases. As for today I authored or co-authored 181 articles in numerous scientific journals, including, as first or last author, Science, New England Journal of Medicine, Journal of Clinical Investigation, Journal of experimental Medicine, Blood and many others. I am an Academic Editor at PLoS ONE and Associate Editor at Frontiers in immunology. I received the Jacques Oudin Price in 2006 and was awarded by Inserm with a price for Scientific Excellence (PES). I also received an iAwards from Sanofi in 2018. Lastly, I am coordinating a consortium project granted by the 4th RHU call (9.9M€), dedicated to develop AI-based tools to reduce the diagnosis wandering and to guide the clinician decision in Primary Immune deficiencies associated with auto-immunity and auto-inflammation.

Domaines de recherche

Sciences du Vivant [q-bio] Génétique humaine Immunologie Immunité adaptative

Compétences

Publications

"darragh-duffy"
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Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients

Marie-Louise Frémond , Alice Hadchouel , Laureline Berteloot , Isabelle Melki , Violaine Bresson
Journal of Allergy and Clinical Immunology: In Practice, 2021, 9 (2), pp.803-818.e11. ⟨10.1016/j.jaip.2020.11.007⟩
Article dans une revue hal-03228789v1
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Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection

Nikaïa Smith , Pedro Goncalves , Bruno Charbit , Ludivine Grzelak , Maxime Beretta
Nature Immunology, 2021, ⟨10.1038/s41590-021-01028-7⟩
Article dans une revue pasteur-03384279v1
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Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection

Nader Yatim , Jeremy Boussier , Pauline Tetu , Nikaïa Smith , Timothée Bruel
Science Advances , 2021, 7 (34), pp.eabg4081. ⟨10.1126/sciadv.abg4081⟩
Article dans une revue pasteur-03334080v1

Type I interferon response and vascular alteration in chilblain‐like lesions during the COVID‐19 outbreak

L. Frumholtz , J.‐d. Bouaziz , M. Battistella , J. Hadjadj , R. Chocron
British Journal of Dermatology, 2021, 185 (6), pp.1176-1185. ⟨10.1111/bjd.20707⟩
Article dans une revue hal-03892796v1

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard , Lindsey Rosen , Qian Zhang , Eleftherios Michailidis , Hans-Heinrich Hoffmann
Science, 2020, 370 (6515), ⟨10.1126/science.abd4585⟩
Article dans une revue hal-04495682v1
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Type I interferon-mediated autoinflammation due to DNase II deficiency

Mathieu Rodéro , Alessandra Tesser , Eva Bartok , Gillian Rice , Erika Della Mina
Nature Communications, 2017, 8 (1), pp.2176. ⟨10.1038/s41467-017-01932-3⟩
Article dans une revue pasteur-01768950v1