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Frédérique FAVIER

14
Documents
Identifiants chercheurs

Présentation

After a PhD in protein crystallography in Strasbourg in the laboratory of D. Moras, I was recruited in 1995 as an assistant professor at the University of Nancy, now University of Lorraine, France. I carry out my research work in the BioMod team at the CRM2 (UMR CNRS-UL 7036). I am currently involved in two main research projects. - The first one concerns glutathione transferases. Although the first structures were established about thirty years ago, the diversity of these proteins throughout living organisms reveals roles that are complex and still poorly known, particularly in plants and fungi. In collaboration with the team of Pr. E. Gelhaye (IAM laboratory, Nancy), we have more than 10 years of experience in the analysis of the structure of these proteins, especially in complex with specialized metabolites, in relation with their function. - My second research area concerns horizontal gene transfer via integrative and conjugative elements (ICE) in Streptococcus thermophilus, a Gram-positive bacterium. We analyze the structures of proteins involved in the early stage of conjugation and in the transfer through the type IV secretion system, in collaboration with Drs N. Soler and B. Douzi in the ICE-TeA team led by Pr. N. Leblond-Bourget (DynAMic laboratory in Nancy) who are long-time specialists in the field. - Previously, I worked for a long time on methionine sulfoxide reductases, which are protective proteins against oxidative stress.

Publications

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"mathieu-schwartz"

Structural insights into the interactions of glutathione transferases with a nitric oxide carrier and sodium nitroprusside

Mathieu Schwartz , Thomas Perrot , Jordan Beurton , Flavien Zannini , Mélanie Morel-Rouhier
Biochemical and Biophysical Research Communications, 2023, 649, pp.79-86. ⟨10.1016/j.bbrc.2023.01.099⟩
Article dans une revue hal-03985658v1
Image document

Diversity of Omega Glutathione Transferases in mushroom-forming fungi revealed by phylogenetic, transcriptomic, biochemical and structural approaches

Thomas Perrot , Mathieu Schwartz , Aurélie Deroy , Jean-Michel Girardet , Annegret Kohler
Fungal Genetics and Biology, 2021, 148, pp.103506. ⟨10.1016/j.fgb.2020.103506⟩
Article dans une revue hal-03143927v1

The structure of Trametes versicolor glutathione transferase Omega 3S bound to its conjugation product glutathionyl-phenethylthiocarbamate reveals plasticity of its active site

Mathieu Schwartz , Thomas Perrot , Melanie Morel-Rouhier , Guillermo Mulliert , Éric Gelhaye
Protein Science, 2019, 28 (6), pp.1143-1150. ⟨10.1002/pro.3620⟩
Article dans une revue hal-02311418v1
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Trametes versicolor glutathione transferase Xi 3, a dual Cys-GST with catalytic specificities of both Xi and Omega classes

Mathieu Schwartz , Thomas Perrot , Aurélie Deroy , Thomas Roret , Melanie Morel-Rouhier
FEBS Letters, 2018, 592 (18), pp.3163-3172. ⟨10.1002/1873-3468.13224⟩
Article dans une revue hal-01959634v1

Fungal Glutathione Transferases as Tools to Explore the Chemical Diversity of Amazonian Wood Extractives

Thomas Perrot , Mathieu Schwartz , Fanny Saiag , Guillaume Salzet , Stéphane Dumarcay
ACS Sustainable Chemistry & Engineering, 2018, 6 (10), pp.13078-13085. ⟨10.1021/acssuschemeng.8b02636⟩
Article dans une revue hal-02492224v1
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Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor

Mathieu Schwartz , Thomas Perrot , Emmanuel Aubert , Stéphane Dumarçay , Frédérique Favier
Scientific Reports, 2018, 8 (1), pp.8472. ⟨10.1038/s41598-018-26601-3⟩
Article dans une revue hal-01843732v1
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Crystal Structure of Saccharomyces cerevisiae ECM4, a Xi-Class Glutathione Transferase that Reacts with Glutathionyl-(hydro)quinones

Mathieu Schwartz , Claude Didierjean , Arnaud Hecker , Jean-Michel Girardet , Mélanie Morel-Rouhier
PLoS ONE, 2016, 11 (10), pp.e0164678. ⟨10.1371/journal.pone.0164678⟩
Article dans une revue hal-01539425v1

Structural view of fungal glutathionyl-hydroquinone reductases

Claude Didierjean , Mathieu Schwartz , Thomas Perrot , Arnaud Hecker , Éric Gelhaye
Acta Crystallographica Section A : Foundations and Advances [2014-..], 2016, 72 (a1), pp.s226 - s226. ⟨10.1107/S205327331609656X⟩
Article dans une revue hal-01549101v1

Crystallographic and biochemical study of glutathione transferase Omega 3S from Trametes versicolor

Mathieu Schwartz , Thomas Perrot , Frédérique Favier , Stéphane Dumarcay , Éric Gelhaye
2. FesBioNet Training School, Sep 2018, Grenoble, France
Poster de conférence hal-04482878v1

Structural evidences of flavonoid-binding glutathione transferases in Trametes versicolor

Mathieu Schwartz , Thomas Perrot , Stéphane Dumarçay , Melanie Morel-Rouhier , Éric Gelhaye
50th International School of Crystallography, Integrative Structural Biology, Jun 2017, Erice (Sicile), France
Poster de conférence hal-04482882v1
Image document

Structural view of fungal glutathionyl-hydroquinone reductases

C. Didierjean , Mathieu Schwartz , Thomas Perrot , Arnaud Hecker , Éric Gelhaye
30. European Crystallographic Meeting, Aug 2016, Basel, Switzerland. Wiley-Blackwell, Acta crystallographica. Section A, Foundations of crystallography, A72, 1 p., 2016, ⟨10.1107/S205327331609656X⟩
Poster de conférence hal-02743022v1

Crystallographic Study of a Xi-class Glutathione Transferase from Trametes versicolor

Mathieu Schwartz , Aurélie Deroy , Éric Gelhaye , Claude Didierjean , Frédérique Favier
2nd redox meeting, May 2015, Vandoeuvre lès Nancy, France
Poster de conférence hal-04482699v1