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Frédérique FAVIER

7
Documents
Identifiants chercheurs

Présentation

After a PhD in protein crystallography in Strasbourg in the laboratory of D. Moras, I was recruited in 1995 as an assistant professor at the University of Nancy, now University of Lorraine, France. I carry out my research work in the BioMod team at the CRM2 (UMR CNRS-UL 7036). I am currently involved in two main research projects. - The first one concerns glutathione transferases. Although the first structures were established about thirty years ago, the diversity of these proteins throughout living organisms reveals roles that are complex and still poorly known, particularly in plants and fungi. In collaboration with the team of Pr. E. Gelhaye (IAM laboratory, Nancy), we have more than 10 years of experience in the analysis of the structure of these proteins, especially in complex with specialized metabolites, in relation with their function. - My second research area concerns horizontal gene transfer via integrative and conjugative elements (ICE) in Streptococcus thermophilus, a Gram-positive bacterium. We analyze the structures of proteins involved in the early stage of conjugation and in the transfer through the type IV secretion system, in collaboration with Drs N. Soler and B. Douzi in the ICE-TeA team led by Pr. N. Leblond-Bourget (DynAMic laboratory in Nancy) who are long-time specialists in the field. - Previously, I worked for a long time on methionine sulfoxide reductases, which are protective proteins against oxidative stress.

Publications

jean-pierre-jacquot

Structural insights into the interactions of glutathione transferases with a nitric oxide carrier and sodium nitroprusside

Mathieu Schwartz , Thomas Perrot , Jordan Beurton , Flavien Zannini , Mélanie Morel-Rouhier
Biochemical and Biophysical Research Communications, 2023, 649, pp.79-86. ⟨10.1016/j.bbrc.2023.01.099⟩
Article dans une revue hal-03985658v1

Atypical features of a Ure2p glutathione transferase from Phanerochaete chrysosporium

Anne Thuillier , Thomas Roret , Frederique Favier , Éric Gelhaye , Jean-Pierre Jacquot
FEBS Letters, 2013, 587 (14), pp.2125 - 2130. ⟨10.1016/j.febslet.2013.05.031⟩
Article dans une revue hal-01268064v1
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Diversification of Fungal Specific Class A Glutathione Transferases in Saprotrophic Fungi

Yann Mathieu , Pascalita Prosper , Frederique Favier , Luc Harvengt , Claude Didierjean
PLoS ONE, 2013, 8 (11), ⟨10.1371/journal.pone.0080298⟩
Article dans une revue hal-01520994v1
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Characterization of a Phanerochaete chrysosporium Glutathione Transferase Reveals a Novel Structural and Functional Class with Ligandin Properties

Yann Mathieu , Pascalita Prosper , Marc Buée , Stephane Dumarcay , Frederique Favier
Journal of Biological Chemistry, 2012, 287 (46), pp.39001 - 39011. ⟨10.1074/jbc.M112.402776⟩
Article dans une revue hal-01268261v1
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Glutathione transferases of Phanerochaete chrysosporium S-glutathionyl-p-hydroquinone reductase belongs to a new structural class

Edgar Meux , Pascalita Prosper , Andrew Ngadin , Claude Didierjean , Mélanie Morel
Journal of Biological Chemistry, 2011, 286 (11), pp.9162-9173. ⟨10.1074/jbc.M110.194548⟩
Article dans une revue hal-02648116v1
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Functional and structural aspects of poplar cytosolic and plastidial type A methionine sulfoxide reductases

Nicolas Rouhier , Brice Kauffmann , Frédérique Tete-Favier , Pasquale Palladino , Pierre Gans
Journal of Biological Chemistry, 2007, 282 (5), pp.3367-3378. ⟨10.1074/jbc.M605007200⟩
Article dans une revue hal-02655515v1

Redox based anti-oxidant systems in plants: Biochemical and structural analyses

Nicolas Rouhier , Cha San Koh , Éric Gelhaye , Catherine Corbier , Frederique Favier
Biochimica et Biophysica Acta (BBA) - General Subjects, 2007, 1780 (11), pp.1249-1260. ⟨10.1016/j.bbagen.2007.12.007⟩
Article dans une revue hal-02662632v1