Jean-Noël Freund

155

Documents

Current affiliations

303623
413289

Contact

Research domains

Life Sciences [q-bio]

Skills

Cellules Souches Cancer Développement Embryonnaire Système Digestif Système Hématopoïétique Transcription Epigénétique Signalisation Gènes Homéotiques

Publications

	CD32 captures committed haemogenic endothelial cells during human embryonic development Rebecca Scarfò , Lauren N. Randolph , Monah Abou Alezz , Mahassen El Khoury , Amélie Gersch Nature Cell Biology, 2024, ⟨10.1038/s41556-024-01403-0⟩ Journal articles hal-04544615v1
	Macrophage depletion overcomes human hematopoietic cell engraftment failure in zebrafish embryo Reine El Omar , Naoill Abdellaoui , Safiatou T Coulibaly , Laura Fontenille , François Lanza Cell Death and Disease, 2024, 15 (5), pp.305. ⟨10.1038/s41419-024-06682-x⟩ Journal articles hal-04567212v1
	General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions. Susanna Säisä-Borreill , Guillaume Davidson , Thomas Kleiber , Andréa Thevenot , Elisabeth Martin Cell death and differentiation, 2023, ⟨10.1038/s41418-022-01109-6⟩ Journal articles hal-03942206v1
	MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice. Sanjeev Kiran Gotru , Elmina Mammadova-Bach , Georgios Sogkas , Michael K Schuhmann , Karen Schmitt Arterioscler Thromb Vasc Biol, 2023, ⟨10.1161/ATVBAHA.122.318115⟩ Journal articles hal-04149721v1
	The Appendix Orchestrates T-Cell Mediated Immunosurveillance in Colitis-Associated Cancer Maxime Collard , Julien Tourneur-Marsille , Mathieu Uzzan , Miguel Albuquerque , Maryline Roy Cellular and Molecular Gastroenterology and Hepatology, 2023, 15 (3), pp.665-687. ⟨10.1016/j.jcmgh.2022.10.016⟩ Journal articles hal-03926262v1
	Concurrent CDX2 cis -deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL Marie Passet , Rathana Kim , Stéphanie Gachet , François Sigaux , Julie Chaumeil Blood, 2022, 139 (24), pp.3505-3518. ⟨10.1182/blood.2021014723⟩ Journal articles hal-03788702v1
	CDX2 controls genes involved in the metabolism of 5-fluorouracil and is associated with reduced efficacy of chemotherapy in colorectal cancer Jean-Baptiste Delhorme , Emilie Bersuder , Chloé Terciolo , Ourania Vlami , Marie Pierrette Chenard Biomedicine and Pharmacotherapy, 2022, 147, pp.112630. ⟨10.1016/j.biopha.2022.112630⟩ Journal articles hal-03788706v1
	Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions Maria Virginia Giolito , Théo La Rosa , Diana Farhat , Serguei Bodoirat , Gabriela D. A. Guardia Molecular Oncology, 2022, ⟨10.1002/1878-0261.13298⟩ Journal articles hal-03792241v1
	Mesalazine initiates an anti-oncogenic β-catenin / MUCDHL negative feed-back loop in colon cancer cells by cell-specific mechanisms Emilie Bersuder , Chloe Terciolo , Mathilde Lechevrel , Elisabeth Martin , Celine Quesnelle Biomedicine and Pharmacotherapy, 2022, 146, pp.112543. ⟨10.1016/j.biopha.2021.112543⟩ Journal articles hal-03788694v1
	Deciphering the Role of Intestinal Crypt Cell Populations in Resistance to Chemotherapy Carla Frau , Catherine Jamard , Gaspard Delpouve , Gabriela D.A. Guardia , Christelle Machon Cancer Research, 2021, 81 (10), pp.2730-2744. ⟨10.1158/0008-5472.CAN-20-2450⟩ Journal articles hal-03810274v1
	CDX2 regulates ACE expression in blood development and leukemia cells Reine El Omar , Emmanuelle Julien , Katia Biasch , Blandine Guffroy , Bruno Lioure Blood Advances, 2021, 5 (7), pp.2012-2016. ⟨10.1182/bloodadvances.2020003563⟩ Journal articles hal-03431252v1
	CDX2 inducible microRNAs sustain colon cancer by targeting multiple DNA damage response pathway factors Swati Priya , Ekjot Kaur , Swati Kulshrestha , Awadhesh Pandit , Isabelle Gross Journal of Cell Science, 2021, 134 (15), ⟨10.1242/jcs.258601⟩ Journal articles hal-03788695v1
	The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms Marine Beck , Mathilde Baranger , Ahlam Moufok-Sadoun , Emilie Bersuder , Isabelle Hinkel Oncogene, 2021, 40, pp.522-535. ⟨10.1038/s41388-020-01546-y⟩ Journal articles hal-03044463v1
	Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells Emmanuelle Julien , Katia Biasch , Reine El Omar , Jean-Noël Freund , Christian Gachet STEM CELLS, 2021, 39 (5), pp.636-649. ⟨10.1002/stem.3339⟩ Journal articles hal-03558010v1
	Murine intestinal stem cells are highly sensitive to modulation of the T3/TRα1-dependent pathway Matthias Godart , Carla Frau , Diana Farhat , Maria Virginia Giolito , Catherine Jamard Development (Cambridge, England), 2021, 148 (8), ⟨10.1242/dev.194357⟩ Journal articles hal-03791609v1
	A Core Response to the CDX2 Homeoprotein During Development and in Pathologies Victor Gourain , Isabelle Duluc , Claire Domon-Dell , Jean-Noël Freund Frontiers in Genetics, 2021, 12, pp.744165. ⟨10.3389/fgene.2021.744165⟩ Journal articles hal-03788711v1
	Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia Cedric Schleiss , Raphael Carapito , Luc-Matthieu Fornecker , Leslie Muller , Nicodème Paul Leukemia, 2021, 35, pp.1463-1474. ⟨10.1038/s41375-021-01221-5⟩ Journal articles hal-03206125v1
	CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition Ava Galland , Victor Gourain , Karima Habbas , Yonca Güler , Elisabeth Martin Molecular Oncology, 2021, 15 (9), pp.2318-2329. ⟨10.1002/1878-0261.12982⟩ Journal articles hal-03713623v1
	Anticancer activity of ruthenium and osmium cyclometalated compounds: identification of ABCB1 and EGFR as resistance mechanisms Cynthia Licona , Jean-Baptiste Delhorme , Gilles Riegel , Vania Vidimar , Ricardo Cerón-Camacho Inorganic Chemistry Frontiers, 2020, 7 (3), pp.678-688. ⟨10.1039/C9QI01148J⟩ Journal articles hal-03013615v1
	Actomyosin, vimentin and LINC complex pull on osteosarcoma nuclei to deform on micropillar topography Nayana Tusamda Wakhloo , Sebastian Anders , Florent Badique , Melanie Eichhorn , Isabelle Brigaud Biomaterials, 2020, 234, pp.119746. ⟨10.1016/j.biomaterials.2019.119746⟩ Journal articles hal-02525268v1
	A Core Proliferative Program Induced By B-Cell Receptor Stimulation in Chronic Lymphocytic Leukemia Cells Cédric Schleiss , Raphaël Carapito , Luc Fornecker , Leslie Muller , Nicodème Paul Blood, 2019, 134, ⟨10.1182/blood-2019-126779⟩ Journal articles hal-03408179v1
	Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs Emmanuelle Grall , Victor Gourain , Asmaa Naïr , Elisabeth Martin , Marie-Christine Birling Cell Death and Disease, 2019, 10 (11), pp.812. ⟨10.1038/s41419-019-2040-0⟩ Journal articles hal-03682397v1
	A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53 Vania Vidimar , Cynthia Licona , Ricardo Cerón-Camacho , Eric Guérin , Pierre Coliat Cancer Letters, 2019, 440-441, pp.145-155. ⟨10.1016/j.canlet.2018.09.029⟩ Journal articles inserm-02363227v1
	Chromatin de-condensation by switching substrate elasticity Morgane Rabineau , Florence Flick , Claire Ehlinger , Eric Mathieu , Isabelle Duluc Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-31023-2⟩ Journal articles hal-03471678v1
	The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms Camille Balbinot , Olivier Armant , Nabila Elarouci , Laetitia Marisa , Elisabeth Martin Journal of Experimental Medicine, 2018, Epub ahead of print. ⟨10.1084/jem.20170934⟩ Journal articles inserm-01707534v1
	Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration. Benoît Romain , Radhia Benbrika-Nehmar , Laetitia Marisa , Michèle Legrain , Viviane Lobstein Oncotarget, 2017, 8 (24), pp.38351-38366. ⟨10.18632/oncotarget.16323⟩ Journal articles inserm-01708889v1
	Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing C. Balbinot , M. Vanier , O. Armant , A. Nair , J. Penichon Cell Death and Differentiation, 2017, 24 (12), pp.2173-2186. ⟨10.1038/cdd.2017.140⟩ Journal articles hal-02552690v1
	Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts. Jean-Philippe Dillenseger , Christian Goetz , Amira Sayeh , C Healy , Isabelle Duluc Journal of Medical Imaging, 2017, 4 (03), pp.035503. ⟨10.1117/1.JMI.4.3.035503⟩ Journal articles inserm-01708886v1
	The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton. Nadine Platet , Isabelle Hinkel , Ludovic Richert , Devadarssen Murdamoothoo , Ahlam Moufok-Sadoun Cancer Letters, 2017, 386, pp.57 - 64. ⟨10.1016/j.canlet.2016.10.040⟩ Journal articles inserm-01708896v1
	Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells Christine Soret , Elisabeth Martin , Isabelle Duluc , Françoise Dantzer , Marie Vanier Cancer Letters, 2016, 374 (2), pp.208-215. ⟨10.1016/j.canlet.2016.02.026⟩ Journal articles inserm-01708904v1
	Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome Laura Gillard , Lore Billiauws , Bogdan Stan-Iuga , Lara Ribeiro , Anne-Charlotte Jarry Scientific Reports, 2016, Scientific Reports 6, Article number: 28345 (2016), [Epub ahead of print]. ⟨10.1038/srep28345⟩ Journal articles inserm-01346345v1
	Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate Morgane Rabineau , Florence Flick , Eric Mathieu , Annie Tu , Bernard Senger Biomaterials, 2015, 37, pp.144-155. ⟨10.1016/j.biomaterials.2014.10.023⟩ Journal articles hal-03811667v1
	Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage Fabien Pertuy , Alicia Aguilar , Catherine Strassel-Risser , Anita Eckly , Jean-Noël Freund Journal of Thrombosis and Haemostasis, 2015, 13 (1), pp.115-125. ⟨10.1111/jth.12784⟩ Journal articles hal-03788703v1
	Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities Jean-Noël Freund , Isabelle Duluc , Jean-Marie Reimund , Isabelle Gross , Claire Domon-Dell World Journal of Gastroenterology, 2015, 21 (5), pp.1436-1443. ⟨10.3748/wjg.v21.i5.1436⟩ Journal articles hal-03788696v1
	TAF4 Inactivation Reveals the 3 Dimensional Growth Promoting Activities of Collagen 6A3 Igor Martianov , Emilie Cler , Isabelle Duluc , Serge Vicaire , Muriel Philipps PLoS ONE, 2014, 9 (2), pp.e87365. ⟨10.1371/journal.pone.0087365⟩ Journal articles hal-03811643v1
	Combined NADPH Oxidase 1 and Interleukin 10 Deficiency Induces Chronic Endoplasmic Reticulum Stress and Causes Ulcerative Colitis-Like Disease in Mice Xavier Tréton , Eric Pedruzzi , Cécile Guichard , Yannick Ladeiro , Shirin Sedghi PLoS ONE, 2014, 9 (7), pp.e101669. ⟨10.1371/journal.pone.0101669⟩ Journal articles hal-03313755v1
	Transcriptional Regulation of the Intestinal Nuclear Bile Acid Farnesoid X Receptor (FXR) by the caudal-related Homeobox 2 (CDX2) Salvatore Modica , Marica Cariello , Annalisa Morgano , Isabelle Gross , Maria Carmela Vegliante Journal of Biological Chemistry, 2014, 289 (41), pp.28421-28432. ⟨10.1074/jbc.M114.571513⟩ Journal articles hal-03807747v1
	Regulation of the tumor suppressor homeogene Cdx2 by HNF4 alpha in intestinal cancer T Saandi , F Baraille , Lylia Derbal-Wolfrom , A Cattin , F Benahmed Oncogene, 2013, 32 (32), pp.3782-3788. ⟨10.1038/onc.2012.401⟩ Journal articles hal-03788700v1
	Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase Jean-Louis Guéant , Maatem Caillerez-Fofou , Shyuefang Battaglia-Hsu , Jean-Marc Alberto , Jean-Noël Freund Biochimie, 2013, 95 (5), pp.1033 - 1040. ⟨10.1016/j.biochi.2013.01.020⟩ Journal articles hal-01704564v1
	Directing nuclear deformation on micropillared surfaces by substrate geometry and cytoskeleton organization Florent Badique , Dimitar Stamov , Patricia Davidson , Mathieu Veuillet , Günter Reiter Biomaterials, 2013, 34 (12), pp.2991-3001. ⟨10.1016/j.biomaterials.2013.01.018⟩ Journal articles hal-02584491v1
	Immunolabelling of Thin Slices of Mouse Descending Colon and Jejunum Julien Bellis , Isabelle Duluc , Jean-Noël Freund , Jan de Mey Bio-protocol , 2013, 3 (20), ⟨10.21769/BioProtoc.942⟩ Journal articles hal-03812037v1
	Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2 Lylia Derbal-Wolfrom , Erwan Pencreach , T Saandi , Marc Aprahamian , Elisabeth Martin Oncogene, 2013, 32 (36), pp.4313-4318. ⟨10.1038/onc.2012.445⟩ Journal articles hal-03812783v1
	Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies Jan de Mey , Jean-Noël Freund Tissue Barriers, 2013, 1 (2), pp.e24965. ⟨10.4161/tisb.24965⟩ Journal articles hal-03792240v1
	Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant Céline Chéry , Alain Hehn , Nadir Mrabet , Abderrahim Oussalah , Elise Jeannesson Biochimie, 2013, 95 (5), pp.995-1001. ⟨10.1016/j.biochi.2013.01.022⟩ Journal articles hal-01474766v1
	Contribution of Soft Substrates to Malignancy and Tumor Suppression during Colon Cancer Cell Division Morgane Rabineau , Leyla Kocgozlu , Denis Dujardin , Bernard Senger , Youssef Haikel PLoS ONE, 2013, 8 (10), pp.e78468. ⟨10.1371/journal.pone.0078468⟩ Journal articles hal-03807780v1
	CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness Bruno Pereira , Sofia Sousa , Rita Barros , Laura Carreto , Patrícia Oliveira Nucleic Acids Research, 2013, 41 (7), pp.3986 - 3999. ⟨10.1093/nar/gkt087⟩ Journal articles hal-02648089v1
	Cdx2 determines the fate of postnatal intestinal endoderm Emma Stringer , Isabelle Duluc , Thoueiba Saandi , Irwin Davidson , Monika Bialecka Development (Cambridge, England), 2012, 139 (3), pp.465-474. ⟨10.1242/dev.070722⟩ Journal articles hal-03807900v1
	The tumor suppressor gene APC controls planar cell polarities central to gut homeostasis. Julien Bellis , Isabelle Duluc , Béatrice Romagnolo , Christine Perret , Maree C. Faux Journal of Cell Biology, 2012, 198, pp.331-341. ⟨10.1083/jcb.201204086⟩ Journal articles hal-00740860v1
	Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells Benjamin Renouf , Christine Soret , Thoueiba Saandi , François Delalande , Elisabeth Martin Nucleic Acids Research, 2012, 40 (8), pp.3456-3469. ⟨10.1093/nar/gkr1242⟩ Journal articles hal-03807892v1
	Gastric intestinal metaplasia revisited: function and regulation of CDX2 Rita Barros , Jean-Noël Freund , Leonor David , Raquel Almeida Trends in Molecular Medicine, 2012, 18 (9), pp.555-563. ⟨10.1016/j.molmed.2012.07.006⟩ Journal articles hal-03790027v1
	Identité et pathologies intestinales : le gène homéotique Cdx2 Jean-Noël Freund Annales de Pathologie, 2012, 32 (5S), pp.S24-S27. ⟨10.1016/j.annpat.2012.08.005⟩ Journal articles hal-03788709v1
	The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity Leyla Kocgozlu , Morgane Rabineau , Géraldine Koenig , Youssef Haikel , Pierre Schaaf Biomaterials, 2012, 33 (3), pp.798-809. ⟨10.1016/j.biomaterials.2011.10.024⟩ Journal articles hal-03811631v1
	Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and beta-Catenin Activity in Colon Cancer Cells Isabelle Hinkel , Isabelle Duluc , Elisabeth Martin , Dominique Guenot , Jean-Noël Freund Gastroenterology, 2012, 142 (4), pp.875-885. ⟨10.1053/j.gastro.2011.12.037⟩ Journal articles hal-03788697v1
	Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi I. Abdallah Hajj Hussein , Jean-Noël Freund , Jean-Marie Reimund , A. Shams , M. Yamine Journal of Biological Regulators and Homeostatic Agents, 2012, 26 (3), pp.515-526 Journal articles hal-03812791v1
	Concerted involvement of Cdx / Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone Cesca van de Ven , Monika Bialecka , Roel Neijts , Teddy Young , Jennifer Rowland Development (Cambridge, England), 2011, 138 (16), pp.3451-3462. ⟨10.1242/dev.066118⟩ Journal articles hal-03807821v1
	CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype Rita Barros , Luis Texeira da Mosta , Joao Pinto-De-Sousa , Isabelle Duluc , Jean-Noël Freund Gut, 2011, 60 (3), pp.290-298. ⟨10.1136/gut.2010.222323⟩ Journal articles hal-03788698v1
	Immunohistochemical expression of CDX2, β-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer Camille Laurent , Magali Svrcek , Jean-François Flejou , Marie-Pierre Chenard , Bernard Duclos Inflammatory Bowel Diseases, 2011, 17 (1), pp.232-240. ⟨10.1002/ibd.21451⟩ Journal articles hal-03811769v1
	Targeted Apc;twist double-mutant mice: A new model of spontaneous osteosarcoma that mimics the human disease Natacha Entz-Werlé , Philippe Choquet , Agnès Neuville , Sabine Kuchler-Bopp , François Clauss Translational Oncology, 2010, 3 (6), pp.344-353. ⟨10.1593/tlo.10169⟩ Journal articles hal-00591470v1
	Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation Rita Barros , Vânia Camilo , Bruno Pereira , Jean-Noël Freund , Leonor David Biochemical Society Transactions, 2010, 38 (2), pp.358-363. ⟨10.1042/BST0380358⟩ Journal articles hal-03811611v1
	CDX2 in Congenital Gut Gastric-Type Heteroplasia and Intestinal-Type Meckel Diverticula Elisabeth Martin , Marie Vanier , Manuela Tavian , Eric Guerin , Claire Domon-Dell Pediatrics, 2010, 126 (3), pp.e723-e727. ⟨10.1542/peds.2009-3512⟩ Journal articles hal-03789463v1
	NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon Nicolas Coant , Sanae Ben Mkaddem , Eric Pedruzzi , Cécile Guichard , Xavier Tréton Molecular and Cellular Biology, 2010, 30 (11), pp.2636-2650. ⟨10.1128/MCB.01194-09⟩ Journal articles hal-03796779v1
	Intestinal Lactase as an Autologous β-Galactosidase Reporter Gene for In Vivo Gene Expression Studies Siamak Salehi , Lorna Eckley , Greta Sawyer , Xiaohong Zhang , Xuebin Dong Human Gene Therapy, 2009, 20 (1), pp.21-30. ⟨10.1089/hum.2008.101⟩ Journal articles hal-03811789v1
	Cdx and Hox Genes Differentially Regulate Posterior Axial Growth in Mammalian Embryos Teddy Young , Jennifer Elizabeth Rowland , Cesca van de Ven , Monika Bialecka , Ana Novoa Developmental Cell, 2009, 17 (4), pp.516-526. ⟨10.1016/j.devcel.2009.08.010⟩ Journal articles hal-03811755v1
	Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2 S Modica , A Morgano , L Salvatore , M Petruzzelli , M-T Vanier Gut, 2009, 58 (9), pp.1250-1259. ⟨10.1136/gut.2008.158386⟩ Journal articles hal-03813788v1
	Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin. Laurent Pons , Shyue-Fang Battaglia-Hsu , Carlos Enrique Orozco-Barrios , Sandrine Ortiou , Celine Chery PLoS ONE, 2009, 4 (7), pp.e6325. ⟨10.1371/journal.pone.0006325⟩ Journal articles hal-00559010v1
	Multiple Regulatory Regions Control the Complex Expression Pattern of the Mouse Cdx2 Homeobox Gene Fairouz Benahmed , Isabelle Gross , Stephen Gaunt , Felix Beck , Frédéric Jehan Gastroenterology, 2008, 135 (4), pp.1238-1247.e3. ⟨10.1053/j.gastro.2008.06.045⟩ Journal articles hal-03811811v1
	Inflammatory bowel disease in rats: Bacterial and chemical interaction Inaya Abdallah Hajj Hussein , Rania Tohme , Kassem Barada , Mostafa Hassan Mostafa , Jean-Noël Freund World Journal of Gastroenterology, 2008, 14 (25), pp.4028. ⟨10.3748/wjg.14.4028⟩ Journal articles hal-03811622v1
	Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer C Bonhomme , A Calon , Elisabeth Martin , S Robine , A Neuville Oncogene, 2008, 27 (32), pp.4497-4502. ⟨10.1038/onc.2008.78⟩ Journal articles hal-03812890v1
	Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines R Barros , B Pereira , I Duluc , M Azevedo , N Mendes The Journal of pathology and bacteriology, 2008, 215 (4), pp.411-420. ⟨10.1002/path.2369⟩ Journal articles hal-03313800v1
	Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors Xiaohong Lu , Jean-Noël Freund , Marc Muller , Juliette Ravey , Jean-Pierre Nicolas Biochimie, 2008, 90 (5), pp.697-704. ⟨10.1016/j.biochi.2007.12.002⟩ Journal articles hal-03811802v1
	The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells Isabelle Gross , Isabelle Duluc , T. Benameur , A. Calon , Elisabeth Martin Oncogene, 2008, 27 (1), pp.107-115. ⟨10.1038/sj.onc.1210601⟩ Journal articles hal-03812788v1
	Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability Clément Subtil , Eric Guérin , Anne Schneider , Marie-Pierre Chenard , Elisabeth Martin Cancer Letters, 2007, 247 (2), pp.197-203. ⟨10.1016/j.canlet.2006.04.004⟩ Journal articles hal-03811777v1
	Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation A Calon , Isabelle Gross , B Lhermitte , Elisabeth Martin , F Beck Gut, 2007, 56 (12), pp.1688-1695. ⟨10.1136/gut.2007.125542⟩ Journal articles hal-03789487v1
	Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival I Gross , O Armant , S Benosman , J de Aguilar , Jean-Noël Freund Cell Death and Differentiation, 2007, 14 (10), pp.1802-1812. ⟨10.1038/sj.cdd.4402188⟩ Journal articles hal-03817466v1
	Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein. Alexandre Calon , Isabelle Gross , Irwin Davidson , Michèle Kedinger , Isabelle Duluc Nucleic Acids Research, 2007, 35 (1), pp.175-85. ⟨10.1093/nar/gkl1034⟩ Journal articles hal-00188312v1
	Precancerous Lesions Upon Sporadic Activation of β-Catenin in Mice Isabelle Coste , Jean-Noël Freund , Simone Spaderna , Thomas Brabletz , Toufic Renno Gastroenterology, 2007, 132 (4), pp.1299-1308. ⟨10.1053/j.gastro.2007.01.029⟩ Journal articles hal-03045926v1
	Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice Philippe Choquet , Alexandre Calon , Élodie Breton , Felix Beck , Claire Domon-Dell Comptes Rendus. Biologies, 2007, 330 (11), pp.821-827. ⟨10.1016/j.crvi.2007.08.002⟩ Journal articles hal-03792413v1
	Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Karine Buchet-Poyau , Julien Courchet , Hervé Le Hir , Bertrand Séraphin , Jean-Yves Scoazec Nucleic Acids Research, 2007, 35 (4), pp.1289-300. ⟨10.1093/nar/gkm016⟩ Journal articles hal-00167447v1
	The Microenvironment Controls CDX2 Homeobox Gene Expression in Colorectal Cancer Cells Fairouz Benahmed , Isabelle Gross , Dominique Guenot , Frédéric Jehan , Elisabeth Martin American Journal of Pathology, 2007, 170 (2), pp.733-744. ⟨10.2353/ajpath.2007.060696⟩ Journal articles hal-03788843v1
	The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells Nicolas Jonckheere , Audrey Vincent , Michaël Perrais , Marie-Paule Ducourouble , Anita Korteland-van Male Journal of Biological Chemistry, 2007, ⟨10.1074/jbc.M700905200⟩ Journal articles hal-02905844v1
	CDX-2 homeobox gene expression in human gastric carcinoma and precursor lesions Hyung-Seok Kim , Ji-Shin Lee , Jean-Noël Freund , Kyung-Whan Min , Jeong-Soo Lee Journal of Gastroenterology and Hepatology, 2006, 21 (2), pp.438-442. ⟨10.1111/j.1440-1746.2005.03933.x⟩ Journal articles hal-03812876v1
	Bile Acids Induce Ectopic Expression of Intestinal Guanylyl Cyclase C Through Nuclear Factor-κB and Cdx2 in Human Esophageal Cells Philip Debruyne , Matthew Witek , Li Gong , Ruth Birbe , Inna Chervoneva Gastroenterology, 2006, 130 (4), pp.1191-1206. ⟨10.1053/j.gastro.2005.12.032⟩ Journal articles hal-03812871v1
	Laminin isoforms: biological roles and effects on the intracellular distribution of nuclear proteins in intestinal epithelial cells. Natacha Turck , Isabelle Gross , Patrick Gendry , Jeanne Stutzmann , Jean-Noël Freund Experimental Cell Research, 2005, 303 (2), pp.494-503. ⟨10.1016/j.yexcr.2004.10.025⟩ Journal articles inserm-00158350v1
	Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. Isabelle Gross , Benoit Lhermitte , Claire Domon-Dell , Isabelle Duluc , Elisabeth Martin Oncogene, 2005, 24 (54), pp.7955-63. ⟨10.1038/sj.onc.1208945⟩ Journal articles inserm-00157949v1
	Down-Regulation of the Homeodomain Factor Cdx2 in Colorectal Cancer by Collagen Type I Thomas Brabletz , Simone Spaderna , Jochen Kolb , Falk Hlubek , Gerhard Faller Cancer Research, 2004, 64 (19), pp.6973-6977. ⟨10.1158/0008-5472.CAN-04-1132⟩ Journal articles hal-03813556v1
	Control of differentiation-induced calbindin-D 9k gene expression in Caco-2 cells by cdx-2 and HNF-1α Liyong Wang , Anna Klopot , Jean-Noel Freund , Jean-Noël Freund , Lauren Dowling AJP - Gastrointestinal and Liver Physiology, 2004, 287 (5), pp.G943-G953. ⟨10.1152/ajpgi.00121.2004⟩ Journal articles hal-03789475v1
	Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer Sang-Pyo Kim , Jong-Wook Park , Sung-Hee Lee , Jun Hee Lim , Byeong-Churl Jang Biochemical and Biophysical Research Communications, 2004, 315 (1), pp.93-99. ⟨10.1016/j.bbrc.2004.01.020⟩ Journal articles hal-03811713v1
	SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. Philippe Blache , Marc van de Wetering , Isabelle Duluc , Claire Domon , Philippe Berta Journal of Cell Biology, 2004, 166 (1), pp.37-47. ⟨10.1083/jcb.200311021⟩ Journal articles hal-00266987v1
	Down-regulation of the Tumor Suppressor PTEN by the Tumor Necrosis Factor-α/Nuclear Factor-κB (NF-κB)-inducing Kinase/NF-κB Pathway Is Linked to a Default IκB-α Autoregulatory Loop Sunghoon Kim , Claire Domon-Dell , Junghee Kang , Dai Chung , Jean-Noël Freund Journal of Biological Chemistry, 2004, 279 (6), pp.4285 - 4291. ⟨10.1074/jbc.m308383200⟩ Journal articles hal-03789566v1
	Klotho Is a Novel β-Glucuronidase Capable of Hydrolyzing Steroid β-Glucuronides Osamu Tohyama , Akihiro Imura , Akiko Iwano , Jean-Noël Freund , Bernard Henrissat Journal of Biological Chemistry, 2004, 279 (11), pp.9777 - 9784. ⟨10.1074/jbc.m312392200⟩ Journal articles hal-03792399v1
	Endoderm- and mesenchyme-dependent commitment of the differentiated epithelial cell types in the developing intestine of rat Christelle Ratineau , Isabelle Duluc , Céline Pourreyron , Michèle Kedinger , Jean-Noël Freund Differentiation, 2003, 71 (2), pp.163-169. ⟨10.1046/j.1432-0436.2003.t01-1-710203.x⟩ Journal articles hal-03813756v1
	Cancer colorectal au cours de la rectocolite hémorragique Jean-Marie Reimund , Camille Laurent , Marie Pierrette Chenard , Jean-Pierre Bellocq , Jean-Noël Freund Hépato-Gastro, 2003, 6 (10), pp.415-423 Journal articles hal-03812785v1
	Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2 Amandine Gautier-Stein , Claire Domon-Dell , Alexandre Calon , Isabelle Baly , Jean-Noël Freund Nucleic Acids Research, 2003, 31 (18), pp.5238-5246. ⟨10.1093/nar/gkg747⟩ Journal articles hal-03813522v1
	Cdx1 homeobox gene during human colon cancer progression Claire Domon-Dell , Anne Schneider , Virginie Moucadel , Eric Guerin , Dominique Guenot Oncogene, 2003, 22 (39), pp.7913-7921. ⟨10.1038/sj.onc.1206756⟩ Journal articles hal-03812880v1
	The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development C Bonhomme , Isabelle Duluc , E Martin , K Chawengsaksophak , Marie Pierrette Chenard Gut, 2003, 52 (10), pp.1465-1471. ⟨10.1136/gut.52.10.1465⟩ Journal articles hal-03797013v1
	PTEN and TNF-α regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-κB–dependent pathway Sunghoon Kim , Claire Domon-Dell , Qingding Wang , Dai Chung , Antonio Di Cristofano Gastroenterology, 2002, 123 (4), pp.1163-1178. ⟨10.1053/gast.2002.36043⟩ Journal articles hal-03817213v1
	Stimulation of Cdx1 by oncogenic β-catenin/Tcf4 in colon cancer cells; opposite effect of the CDX2 homeoprotein Claire Domon-Dell , Jean-Noël Freund FEBS Letters, 2002, 518 (1-3), pp.83-87. ⟨10.1016/s0014-5793(02)02650-9⟩ Journal articles hal-03791635v1
	The homeobox gene Cdx1 belongs to the p53-p21(WAF)-Bcl-2 network in intestinal epithelial cells Virginie Moucadel , Maria Serena Totaro , Claire Domon-Dell , Philippe Soubeyran , Jean Charles Dagorn Biochemical and Biophysical Research Communications, 2002, 297 (3), pp.607-615. ⟨10.1016/s0006-291x(02)02250-7⟩ Journal articles hal-03812793v1
	Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway Eek-Hoon Jho , Tong Zhang , Claire Domon , Choun-Ki Joo , Jean-Noël Freund Molecular and Cellular Biology, 2002, 22 (4), pp.1172-1183. ⟨10.1128/MCB.22.4.1172-1183.2002⟩ Journal articles hal-03788855v1
	Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells Claire Domon-Dell , Q Wang , S Kim , Michèle Kedinger , B M Evers Gut, 2002, 50 (4), pp.525-529. ⟨10.1136/gut.50.4.525⟩ Journal articles hal-03796863v1
	Differentially expressed endoderm and mesenchyme genes along the fetal rat intestine Isabelle Duluc , C. Hoff , Michèle Kedinger , Jean-Noël Freund Genesis - The Journal of Genetics and Development, 2001, 29 (2), pp.55-59 Journal articles hal-03812797v1
	Functional Interference between Thyroid Hormone Receptor α (TRα) and Natural Truncated TRΔα Isoforms in the Control of Intestine Development Michelina Plateroti , Karine Gauthier , Claire Domon-Dell , Jean-Noël Freund , Jacques Samarut Molecular and Cellular Biology, 2001, 21 (14), pp.4761-4772. ⟨10.1128/MCB.21.14.4761-4772.2001⟩ Journal articles hal-03791255v1
	Aspects cellulaires et molécuaires du développemet intestinal Jean-Noël Freund Hépato-Gastro, 2000, 1 (7), pp.47-56 Journal articles hal-03814378v1
	Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine H. Lickert , Claire Domon , G. Huls , C. Wehrle , Isabelle Duluc Development (Cambridge, England), 2000, 127 (17), pp.3805-3813 Journal articles hal-03812792v1
	Involvement of T3Rα- and β-receptor subtypes in mediation of T3 functions during postnatal murine intestinal development☆, ☆☆, ★ Michelina Plateroti , Olivier Chassande , Alexandre Fraichard , Karine Gauthier , Jean-Noël Freund Gastroenterology, 1999, 116 (6), pp.1367-1378. ⟨10.1016/S0016-5085(99)70501-9⟩ Journal articles hal-03818728v1
	Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras Olivier Lorentz , Axelle Cadoret , Isabelle Duluc , Jacqueline Capeau , Christian Gespach Oncogene, 1999, 18 (1), pp.87-92. ⟨10.1038/sj.onc.1202280⟩ Journal articles hal-03812197v1
	Production of low-lactose milk by ectopic expression of intestinal lactase in the mouse mammary gland Bernard Jost , Jean-Luc Vilotte , Isabelle Duluc , Jean-Luc Rodeau , Jean-Noël Freund Nature Biotechnology, 1999, 17, pp.160-164 Journal articles hal-02696428v1
	Prédigestion d'un composant du lait, le lactose, dans la glande mammaire Jean-Noël Freund Médecine/Sciences, 1999, 15 (8-9), pp.1058-1059. ⟨10.4267/10608/1487⟩ Journal articles hal-03817261v1
	Promotion of intestinal carcinogenesis by dietary methionine B. Duranton , Jean-Noël Freund , M. Galluser , R. Schleiffer , F. Gossé Carcinogenesis, 1999, 20 (3), pp.493-497 Journal articles hal-03812799v1
	Intestinal Epithelial-Mesenchymal Cell Interactions Michèle Kedinger , Isabelle Duluc , C. Fritsch , O. Lorentz , M. Plateroti Annals of the New York Academy of Sciences, 1998, 859 (1 INTESTINAL PL), pp.1-17. ⟨10.1111/j.1749-6632.1998.tb11107.x⟩ Journal articles hal-03814869v1
	Lactase is unchanged in suckling mice fed with lactose-free milk Bernard Jost , Isabelle Duluc , Jean-Luc Vilotte , Jean-Noël Freund Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology, 1998, 22, pp.863-867 Journal articles hal-02690133v1
	The Cdx-1 and Cdx-2 homeobox genes in the intestine Jean-Noël Freund , Claire Domon-Dell , Michèle Kedinger , Isabelle Duluc Biochemistry and Cell Biology, 1998, 76 (6), pp.957-969. ⟨10.1139/o99-001⟩ Journal articles hal-03817632v1
	Cellular and molecular partners involved in gut morphogenesis and differentiation Michèle Kedinger , O. Lefebvre , Isabelle Duluc , Jean-Noël Freund , Patricia Simon-Assmann Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (1934–1990), 1998, 353 (1370), pp.847-856. ⟨10.1098/rstb.1998.0249⟩ Journal articles hal-03813452v1
	Subepithelial fibroblast cell lines from different levels of gut axis display regional characteristics Michelina Plateroti , D. C. Rubin , Isabelle Duluc , R. Singh , C. Foltzer-Jourdainne American Journal of Physiology, 1998, 274 (5 Pt 1) Journal articles hal-03812790v1
	Mesenchyme-mediated effects of retinoic acid during rat intestinal development M. Plateroti , Jean-Noël Freund , C. Leberquier , Michèle Kedinger Journal of Cell Science, 1997, 110 ( Pt 10), pp.1227-1238 Journal articles hal-03812798v1
	Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells Isabelle Duluc , Olivier Lorentz , Christine Fritsch , Cathy Leberquier , Michèle Kedinger Journal of Cell Science, 1997, 110 ( Pt 11), pp.1317-1324. ⟨10.1242/jcs.110.11.1317⟩ Journal articles hal-03812787v1
	Key Role of the Cdx2 Homeobox Gene in Extracellular Matrix–mediated Intestinal Cell Differentiation Olivier Lorentz , Isabelle Duluc , Adèle De Arcangelis , Patricia Simon-Assmann , Michèle Kedinger Journal of Cell Biology, 1997, 139 (6), pp.1553-1565. ⟨10.1083/jcb.139.6.1553⟩ Journal articles hal-03791318v1
	Identification of homologues of the mammalian intestinal lactase gene in non-mammals (birds and molluscs) Jean-Noël Freund , Bernard Jost , Olivier Lorentz , Isabelle Duluc Biochemical Journal, 1997, 322 (2), pp.491-498. ⟨10.1042/bj3220491⟩ Journal articles hal-03791310v1
	Functional diversity and interactions between the repeat domains of rat intestinal lactase Bernard Jost , Isabelle Duluc , Melville Richardson , Richard Lathe , Jean-Noël Freund Biochemical Journal, 1997, 327 (1), pp.95-103. ⟨10.1042/bj3270095⟩ Journal articles hal-03791201v1
	Ultrastructural study of intestinal lactase gene expression Jean-Noël Freund , Bernard Jost , Isabelle Duluc , G. Morel Biology of the Cell, 1995, 83 (2-3), pp.211-217 Journal articles hal-03812800v1
	Verification of the lactase site of rat lactase-phlorizin hydrolase by site-directed mutagenesis Adriana Neele , Alexandra W.C. Einerhand , Jan Dekker , Hans Büller , Jean-Noël Freund Gastroenterology, 1995, 109 (4), pp.1234-1240. ⟨10.1016/0016-5085(95)90583-9⟩ Journal articles hal-03812281v1
	Activity of the rat lactase gene promoter in transfected human colon cancer cells R. Boukamel , P. Neuville , Isabelle Duluc , Jean-Noël Freund Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie, 1995, 318 (11), pp.1133-1140 Journal articles hal-03814373v1
	Precocious and reversible expression of sucrase-isomaltase unrelated to intestinal cell turnover E. Nsi-Emvo , C. Foltzer-Jourdainne , Francis Raul , F. Gosse , Isabelle Duluc AJP - Gastrointestinal and Liver Physiology, 1994, 266 (4), pp.G568-G575. ⟨10.1152/ajpgi.1994.266.4.G568⟩ Journal articles hal-03812230v1
	Fetal endoderm primarily holds the temporal and positional information required for mammalian intestinal development. Isabelle Duluc , Jean-Noël Freund , C Leberquier , Michèle Kedinger Journal of Cell Biology, 1994, 126 (1), pp.211-221. ⟨10.1083/jcb.126.1.211⟩ Journal articles hal-03789578v1
	The cis -element CE-LPH1 of the rat intestinal lactase gene promoter interacts in vitro with several nuclear factors present in endodermal tissues Rita Boukamel , Jean-Noël Freund FEBS Letters, 1994, 353 (1), pp.108-112. ⟨10.1016/0014-5793(94)01026-9⟩ Journal articles hal-03788837v1
	Multiple levels of control of the stage- and region-specific expression of rat intestinal lactase. Isabelle Duluc , Bernard Jost , Jean-Noël Freund Journal of Cell Biology, 1993, 123 (6), pp.1577-1586. ⟨10.1083/jcb.123.6.1577⟩ Journal articles hal-03792443v1
	Dietary control of the lactase mRNA distribution along the rat small intestine Isabelle Duluc , M. Galluser , Francis Raul , Jean-Noël Freund American Journal of Physiology, 1992, 262 (6 Pt 1) Journal articles hal-03814382v1
	The rat LPH Gene 5′ region: comparative structure with the human gene Rita Boukamel , Jean-Noël Freund DNA Sequence, 1992, 3 (2), pp.119-121. ⟨10.3109/10425179209034006⟩ Journal articles hal-03817641v1
	Gradient expression of Cdx along the rat intestine throughout postnatal development Jean-Noël Freund , Rita Boukamel , Aziz Benazzouz FEBS Letters, 1992, 314 (2), pp.163-166. ⟨10.1016/0014-5793(92)80965-j⟩ Journal articles hal-03788821v1
	Do co-translated product(s) of lactase-phlorizin hydrolase accumulate in the rat intestine? Jean-Noël Freund Cellular and Molecular Biology, 1992, 38 (7), pp.713-718 Journal articles hal-03814375v1
	Adaptation of intestinal hydrolases to starvation in rats: effect of thyroid function M. Galluser , R. Belkhou , Jean-Noël Freund , Isabelle Duluc , N. Torp Journal of Comparative Physiology B, 1991, 161 (4), pp.357-361. ⟨10.1007/BF00260793⟩ Journal articles hal-03812789v1
	Sequence of the precursor of intestinal lactase-phlorizin hydrolase from fetal rat Isabelle Duluc , Rita Boukamel , Ned Mantei , Giorgio Semenza , Francis Raul Gene, 1991, 103 (2), pp.275-276. ⟨10.1016/0378-1119(91)90286-K⟩ Journal articles hal-03817319v1
	Lactase expression is controlled differently in the jejunum and ileum during development in rats Jean-Noël Freund , Francis Raul , Isabelle Duluc Gastroenterology, 1991, 100 (2), pp.388-394. ⟨10.5555/uri:pii:0016508591902072⟩ Journal articles hal-03818483v1
	Rat lactase activity and mRNA expression in relation to the thyroid and corticoid status Jean-Noël Freund , C. Foltzer-Jourdainne , Isabelle Duluc , M. Galluser , F. Gosse Cellular and Molecular Biology, 1991, 37 (4), pp.463-466 Journal articles hal-03818491v1
	Derivatives of Plant Beta-GIucans Are Hydrolyzed by Intestinal Lactase-Phlorizin Hydrolase of Mammals Jean-Noël Freund , Francine Gossé Enzyme Protein, 1991, 45 (1-2), pp.71-74. ⟨10.1159/000468868⟩ Journal articles hal-03813472v1
	Specific expression of lactase in the jejunum and colon during postnatal development and hormone treatments in the rat Jean-Noël Freund , Isabelle Duluc , C Foltzer-Jourdainne , F Gosse , Francis Raul Biochemical Journal, 1990, 268 (1), pp.99-103. ⟨10.1042/bj2680099⟩ Journal articles hal-03796808v1
	Comparative expression of the mRNA for three intestinal hydrolases during postnatal development in the rat Jean-Noël Freund , N. Torp , Isabelle Duluc , C. Foltzer-Jourdainne , M. Danielsen Cellular and Molecular Biology, 1990, 36 (6), pp.729-736 Journal articles hal-03814379v1
	Type IV collagen mRNA accumulates in the mesenchymal compartment at early stages of murine developing intestine. P Simon-Assmann , F Bouziges , Jean-Noël Freund , F Perrin-Schmitt , Michèle Kedinger Journal of Cell Biology, 1990, 110 (3), pp.849-857. ⟨10.1083/jcb.110.3.849⟩ Journal articles hal-03788848v1
	Different expression of the mRNA detected by the cDNA for fetal rat lactase in the jejunum and colon Isabelle Duluc , Jean-Noël Freund , N. Mantei , Francis Raul Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology, 1990, 14 (8-9), pp.635-640 Journal articles hal-03817670v1
	The gene for intestinal sucrase-isomaltase as member of a gene family Jean-Noël Freund , R. Heilig , N. Lehner , Francis Raul Cellular and Molecular Biology, 1989, 35 (3), pp.313-324 Journal articles hal-03818484v1
	Discrepancy between the intestinal lactase enzymatic activity and mRNA accumulation in sucklings and adults Effect of starvation and thyroxine treatment Jean-Noël Freund , Isabelle Duluc , Francis Raul FEBS Letters, 1989, 248 (1-2), pp.39-42. ⟨10.1016/0014-5793(89)80427-2⟩ Journal articles hal-03790118v1
	Synthetic probes to investigate the genetic arrangement of the coding sequences involved in the pyrimidine pathway over the phylogenesis Jean-Noël Freund , Bruno Jarry Life Science Advance Molecular Genetics, 1988, 7, pp.1-5 Journal articles hal-03812795v1
	The rudimentary gene of Drosophila melanogaster encodes four enzymic functions Jean-Noël Freund , B.P. Jarry Journal of Molecular Biology, 1987, 193 (1), pp.1-13. ⟨10.1016/0022-2836(87)90621-8⟩ Journal articles hal-03817643v1
	Molecular organization of the rudimentary gene of Drosophila melanogaster Jean-Noël Freund , W. Vergis , P. Schedl , B.P. Jarry Journal of Molecular Biology, 1986, 189 (1), pp.25-36. ⟨10.1016/0022-2836(86)90378-5⟩ Journal articles hal-03817199v1
	Organization of transcription units around the Drosophila melanogaster rudimentary locus and temporal pattern of expression J. Rawls , Jean-Noël Freund , B. Jarry , C. Louis , W. Segraves Molecular and General Genetics MGG, 1986, 202 (3), pp.493-499. ⟨10.1007/BF00333283⟩ Journal articles hal-03817202v1

	Su1866 The CDx2 Homeoprotein Inhibits DNA Repair by Non-Homologous End Joining Specifically in Colon Cancer but Not in Leukemia Cells Benjamin Renouf , Christine Soret , Thoueiba Saandi , François Delalande , Elisabeth Martin DDW2012, Digestive Disease Week, May 2012, San Diego, United States. pp.S-522, ⟨10.1016/s0016-5085(12)62005-8⟩ Conference papers hal-03811655v1
	Levels and Factors of Control of Small-Intestinal Lactase Expression in the Laboratory Rat Jean-Noël Freund , R. Boukamel , Isabelle Duluc 2nd International Symposium on Common Food Intolerances: Health Risks due to Lack or Consumption of Milk in Human Nutrition and Adult-Type Hypolactasia, Capri, October 1992, Oct 1992, Capri, Italy Conference papers hal-03818485v1

	Inflammatory Bowel Disease-Associated Cancer Jean-Marie Reimund , Jean-Noël Freund Encyclopedia of Cancer, Springer Berlin Heidelberg, pp.2258-2263, 2017, ⟨10.1007/978-3-662-46875-3_3046⟩ Book sections hal-03812029v1
	Ulcerative Colitis-Associated Colorectal Cancer Prevention by 5-Aminosalicylates: Current Status and Perspectives Jean-Marie Reimund , Marion Tavernier , Stephanie Viennot , Inaya Abdallah Hajj Hussein , Benoit Dupont Ulcerative Colitis from Genetics to Complications, InTech, 2012, ⟨10.5772/25577⟩ Book sections hal-02461233v1
	Inflammatory Bowel Disease-associated Cancer Jean-Marie Reimund , Jean-Noël Freund Manfred Schwab. Encyclopedia of Cancer, Springer Berlin Heidelberg, pp.1525-1528, 2008, 978-3-540-36847-2 Book sections hal-03814374v1
	Cell interactions through the basement membrane in intestinal development and differentiation Michèle Kedinger , Jean-Noël Freund , J. F. Launay , Patricia Simon-Assmann , I. R. Sanderson Development of the gastrointestinal tract, pp.83-102, 2000 Book sections hal-03814377v1
	Homeobox genes and intestinal development Claire Domon-Dell , Isabelle Duluc , Michèle Kedinger , Jean-Noël Freund Cytokines and Cell Homeostasis in the Gastroinstestinal Tract, 113, Springer, pp.72-81, 2000, 978-0-7923-8758-9 Book sections hal-03812794v1
	Regulation of the epithelial-mesenchymal cross-talk in the gut Michèle Kedinger , J. Olsen , C. Fritsch , Patricia Simon-Assmann , Jean-Noël Freund Intestinal Mucosa and its Diseases - Pathophysiology and Clinics, 110, Springer, 1999, 978-0-7923-8754-1 Book sections hal-03812796v1
	Cellular and molecular mechanisms regulating intestinal development Michèle Kedinger , M. Plateroti , V. Orian-Rousseau , O. Lorentz , C. Fritsch Cellular and molecular mechanisms regulating intestinal development, 94, Springer, 1997, 978-0-7923-8726-8 Book sections hal-03814376v1

	Gut epithelium Michèle Kedinger , Jean-Noël Freund Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine, 2005, pp.736-739 Other publications hal-03812786v1

Jean-Noël Freund

Research domains

Skills

Publications

CD32 captures committed haemogenic endothelial cells during human embryonic development

Macrophage depletion overcomes human hematopoietic cell engraftment failure in zebrafish embryo

General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions.

MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.

The Appendix Orchestrates T-Cell Mediated Immunosurveillance in Colitis-Associated Cancer

Concurrent CDX2 cis -deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL

CDX2 controls genes involved in the metabolism of 5-fluorouracil and is associated with reduced efficacy of chemotherapy in colorectal cancer

Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions

Mesalazine initiates an anti-oncogenic β-catenin / MUCDHL negative feed-back loop in colon cancer cells by cell-specific mechanisms

Deciphering the Role of Intestinal Crypt Cell Populations in Resistance to Chemotherapy

CDX2 regulates ACE expression in blood development and leukemia cells

CDX2 inducible microRNAs sustain colon cancer by targeting multiple DNA damage response pathway factors

The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms

Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells

Murine intestinal stem cells are highly sensitive to modulation of the T3/TRα1-dependent pathway

A Core Response to the CDX2 Homeoprotein During Development and in Pathologies

Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia

CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition

Anticancer activity of ruthenium and osmium cyclometalated compounds: identification of ABCB1 and EGFR as resistance mechanisms

Actomyosin, vimentin and LINC complex pull on osteosarcoma nuclei to deform on micropillar topography

A Core Proliferative Program Induced By B-Cell Receptor Stimulation in Chronic Lymphocytic Leukemia Cells

Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs

A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53

Chromatin de-condensation by switching substrate elasticity

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms

Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration.

Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing

Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts.

The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells

Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome

Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate

Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage

Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities

TAF4 Inactivation Reveals the 3 Dimensional Growth Promoting Activities of Collagen 6A3

Combined NADPH Oxidase 1 and Interleukin 10 Deficiency Induces Chronic Endoplasmic Reticulum Stress and Causes Ulcerative Colitis-Like Disease in Mice

Transcriptional Regulation of the Intestinal Nuclear Bile Acid Farnesoid X Receptor (FXR) by the caudal-related Homeobox 2 (CDX2)

Regulation of the tumor suppressor homeogene Cdx2 by HNF4 alpha in intestinal cancer

Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase

Directing nuclear deformation on micropillared surfaces by substrate geometry and cytoskeleton organization

Immunolabelling of Thin Slices of Mouse Descending Colon and Jejunum

Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2

Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies

Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant

Contribution of Soft Substrates to Malignancy and Tumor Suppression during Colon Cancer Cell Division

CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness

Cdx2 determines the fate of postnatal intestinal endoderm

The tumor suppressor gene APC controls planar cell polarities central to gut homeostasis.

Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells

Gastric intestinal metaplasia revisited: function and regulation of CDX2

Identité et pathologies intestinales : le gène homéotique Cdx2

The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity

Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and beta-Catenin Activity in Colon Cancer Cells

Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi

Concerted involvement of Cdx / Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype

Immunohistochemical expression of CDX2, β-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer

Targeted Apc;twist double-mutant mice: A new model of spontaneous osteosarcoma that mimics the human disease

Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation

CDX2 in Congenital Gut Gastric-Type Heteroplasia and Intestinal-Type Meckel Diverticula

NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon

Intestinal Lactase as an Autologous β-Galactosidase Reporter Gene for In Vivo Gene Expression Studies

Cdx and Hox Genes Differentially Regulate Posterior Axial Growth in Mammalian Embryos

Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2

Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin.

Multiple Regulatory Regions Control the Complex Expression Pattern of the Mouse Cdx2 Homeobox Gene

Inflammatory bowel disease in rats: Bacterial and chemical interaction

Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer

Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines

Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors

The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells

Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability

Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation

Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival

Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein.

Precancerous Lesions Upon Sporadic Activation of β-Catenin in Mice