Jean-Noël Freund

INSERM U1256-NGERE Université de Lorraine
160
Documents
Affiliations actuelles
  • Institut National de la Santé et de la Recherche Médicale (INSERM)
  • Université de Lorraine (UL)
Contact

Domaines de recherche

Sciences du Vivant [q-bio]

Compétences

Cellules Souches Cancer Développement Embryonnaire Système Digestif Système Hématopoïétique Transcription Epigénétique Signalisation Gènes Homéotiques

Publications

Publications

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CD32 captures committed haemogenic endothelial cells during human embryonic development

Rebecca Scarfò , Lauren N. Randolph , Monah Abou Alezz , Mahassen El Khoury , Amélie Gersch et al.
Nature Cell Biology, 2024, ⟨10.1038/s41556-024-01403-0⟩
Article dans une revue hal-04544615 v1
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Macrophage depletion overcomes human hematopoietic cell engraftment failure in zebrafish embryo

Reine El Omar , Naoill Abdellaoui , Safiatou T Coulibaly , Laura Fontenille , François Lanza et al.
Cell Death and Disease, 2024, 15 (5), pp.305. ⟨10.1038/s41419-024-06682-x⟩
Article dans une revue hal-04567212 v1
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The Appendix Orchestrates T-Cell Mediated Immunosurveillance in Colitis-Associated Cancer

Maxime Collard , Julien Tourneur-Marsille , Mathieu Uzzan , Miguel Albuquerque , Maryline Roy et al.
Cellular and Molecular Gastroenterology and Hepatology, 2023, 15 (3), pp.665-687. ⟨10.1016/j.jcmgh.2022.10.016⟩
Article dans une revue hal-03926262 v1
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General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions.

Susanna Säisä-Borreill , Guillaume Davidson , Thomas Kleiber , Andréa Thevenot , Elisabeth Martin et al.
Cell death and differentiation, 2023, ⟨10.1038/s41418-022-01109-6⟩
Article dans une revue hal-03942206 v1
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MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.

Sanjeev Kiran Gotru , Elmina Mammadova-Bach , Georgios Sogkas , Michael K Schuhmann , Karen Schmitt et al.
Arterioscler Thromb Vasc Biol, 2023, ⟨10.1161/ATVBAHA.122.318115⟩
Article dans une revue hal-04149721 v1
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CDX2 controls genes involved in the metabolism of 5-fluorouracil and is associated with reduced efficacy of chemotherapy in colorectal cancer

Jean-Baptiste Delhorme , Emilie Bersuder , Chloé Terciolo , Ourania Vlami , Marie Pierrette Chenard et al.
Biomedicine and Pharmacotherapy, 2022, 147, pp.112630. ⟨10.1016/j.biopha.2022.112630⟩
Article dans une revue hal-03788706 v1
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Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions

Maria Virginia Giolito , Théo La Rosa , Diana Farhat , Serguei Bodoirat , Gabriela D. A. Guardia et al.
Molecular Oncology, 2022, ⟨10.1002/1878-0261.13298⟩
Article dans une revue hal-03792241 v1
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Concurrent CDX2 cis -deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL

Marie Passet , Rathana Kim , Stéphanie Gachet , François Sigaux , Julie Chaumeil et al.
Blood, 2022, 139 (24), pp.3505-3518. ⟨10.1182/blood.2021014723⟩
Article dans une revue hal-03788702 v1
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Mesalazine initiates an anti-oncogenic β-catenin / MUCDHL negative feed-back loop in colon cancer cells by cell-specific mechanisms

Emilie Bersuder , Chloe Terciolo , Mathilde Lechevrel , Elisabeth Martin , Celine Quesnelle et al.
Biomedicine and Pharmacotherapy, 2022, 146, pp.112543. ⟨10.1016/j.biopha.2021.112543⟩
Article dans une revue hal-03788694 v1
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A Core Response to the CDX2 Homeoprotein During Development and in Pathologies

Victor Gourain , Isabelle Duluc , Claire Domon-Dell , Jean-Noël Freund
Frontiers in Genetics, 2021, 12, pp.744165. ⟨10.3389/fgene.2021.744165⟩
Article dans une revue hal-03788711 v1

Murine intestinal stem cells are highly sensitive to modulation of the T3/TRα1-dependent pathway

Matthias Godart , Carla Frau , Diana Farhat , Maria Virginia Giolito , Catherine Jamard et al.
Development (Cambridge, England), 2021, 148 (8), ⟨10.1242/dev.194357⟩
Article dans une revue hal-03791609 v1
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Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia

Cedric Schleiss , Raphael Carapito , Luc-Matthieu Fornecker , Leslie Muller , Nicodème Paul et al.
Leukemia, 2021, 35, pp.1463-1474. ⟨10.1038/s41375-021-01221-5⟩
Article dans une revue hal-03206125 v1

Deciphering the Role of Intestinal Crypt Cell Populations in Resistance to Chemotherapy

Carla Frau , Catherine Jamard , Gaspard Delpouve , Gabriela D.A. Guardia , Christelle Machon et al.
Cancer Research, 2021, 81 (10), pp.2730-2744. ⟨10.1158/0008-5472.CAN-20-2450⟩
Article dans une revue hal-03810274 v1
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CDX2 regulates ACE expression in blood development and leukemia cells

Reine El Omar , Emmanuelle Julien , Katia Biasch , Blandine Guffroy , Bruno Lioure et al.
Blood Advances, 2021, 5 (7), pp.2012-2016. ⟨10.1182/bloodadvances.2020003563⟩
Article dans une revue hal-03431252 v1

The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms

Marine Beck , Mathilde Baranger , Ahlam Moufok-Sadoun , Emilie Bersuder , Isabelle Hinkel et al.
Oncogene, 2021, 40, pp.522-535. ⟨10.1038/s41388-020-01546-y⟩
Article dans une revue hal-03044463 v1
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Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells

Emmanuelle Julien , Katia Biasch , Reine El Omar , Jean-Noël Freund , Christian Gachet et al.
STEM CELLS, 2021, 39 (5), pp.636-649. ⟨10.1002/stem.3339⟩
Article dans une revue hal-03558010 v1
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CDX2 inducible microRNAs sustain colon cancer by targeting multiple DNA damage response pathway factors

Swati Priya , Ekjot Kaur , Swati Kulshrestha , Awadhesh Pandit , Isabelle Gross et al.
Journal of Cell Science, 2021, 134 (15), ⟨10.1242/jcs.258601⟩
Article dans une revue hal-03788695 v1

CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition

Ava Galland , Victor Gourain , Karima Habbas , Yonca Güler , Elisabeth Martin et al.
Molecular Oncology, 2021, 15 (9), pp.2318-2329. ⟨10.1002/1878-0261.12982⟩
Article dans une revue hal-03713623 v1

Anticancer activity of ruthenium and osmium cyclometalated compounds: identification of ABCB1 and EGFR as resistance mechanisms

Cynthia Licona , Jean-Baptiste Delhorme , Gilles Riegel , Vania Vidimar , Ricardo Cerón-Camacho et al.
Inorganic Chemistry Frontiers, 2020, 7 (3), pp.678-688. ⟨10.1039/C9QI01148J⟩
Article dans une revue hal-03013615 v1
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Actomyosin, vimentin and LINC complex pull on osteosarcoma nuclei to deform on micropillar topography

Nayana Tusamda Wakhloo , Sebastian Anders , Florent Badique , Melanie Eichhorn , Isabelle Brigaud et al.
Biomaterials, 2020, 234, pp.119746. ⟨10.1016/j.biomaterials.2019.119746⟩
Article dans une revue hal-02525268 v1
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A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53

Vania Vidimar , Cynthia Licona , Ricardo Cerón-Camacho , Eric Guérin , Pierre Coliat et al.
Cancer Letters, 2019, 440-441, pp.145-155. ⟨10.1016/j.canlet.2018.09.029⟩
Article dans une revue inserm-02363227 v1
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Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs

Emmanuelle Grall , Victor Gourain , Asmaa Naïr , Elisabeth Martin , Marie-Christine Birling et al.
Cell Death and Disease, 2019, 10 (11), pp.812. ⟨10.1038/s41419-019-2040-0⟩
Article dans une revue hal-03682397 v1

A Core Proliferative Program Induced By B-Cell Receptor Stimulation in Chronic Lymphocytic Leukemia Cells

Cédric Schleiss , Raphaël Carapito , Luc Fornecker , Leslie Muller , Nicodème Paul et al.
Article dans une revue hal-03408179 v1
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Chromatin de-condensation by switching substrate elasticity

Morgane Rabineau , Florence Flick , Claire Ehlinger , Eric Mathieu , Isabelle Duluc et al.
Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-31023-2⟩
Article dans une revue hal-03471678 v1
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The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms

Camille Balbinot , Olivier Armant , Nabila Elarouci , Laetitia Marisa , Elisabeth Martin et al.
Journal of Experimental Medicine, 2018, Epub ahead of print. ⟨10.1084/jem.20170934⟩
Article dans une revue inserm-01707534 v1

Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing

C. Balbinot , M. Vanier , O. Armant , A. Nair , J. Penichon et al.
Cell Death and Differentiation, 2017, 24 (12), pp.2173-2186. ⟨10.1038/cdd.2017.140⟩
Article dans une revue hal-02552690 v1
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Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration.

Benoît Romain , Radhia Benbrika-Nehmar , Laetitia Marisa , Michèle Legrain , Viviane Lobstein et al.
Oncotarget, 2017, 8 (24), pp.38351-38366. ⟨10.18632/oncotarget.16323⟩
Article dans une revue inserm-01708889 v2

Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts.

Jean-Philippe Dillenseger , Christian Goetz , Amira Sayeh , C Healy , Isabelle Duluc et al.
Journal of Medical Imaging, 2017, 4 (03), pp.035503. ⟨10.1117/1.JMI.4.3.035503⟩
Article dans une revue inserm-01708886 v1

The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

Nadine Platet , Isabelle Hinkel , Ludovic Richert , Devadarssen Murdamoothoo , Ahlam Moufok-Sadoun et al.
Cancer Letters, 2017, 386, pp.57 - 64. ⟨10.1016/j.canlet.2016.10.040⟩
Article dans une revue inserm-01708896 v1
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Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells

Christine Soret , Elisabeth Martin , Isabelle Duluc , Françoise Dantzer , Marie Vanier et al.
Cancer Letters, 2016, 374 (2), pp.208-215. ⟨10.1016/j.canlet.2016.02.026⟩
Article dans une revue inserm-01708904 v1
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Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome

Laura Gillard , Lore Billiauws , Bogdan Stan-Iuga , Lara Ribeiro , Anne-Charlotte Jarry et al.
Scientific Reports, 2016, Scientific Reports 6, Article number: 28345 (2016), [Epub ahead of print]. ⟨10.1038/srep28345⟩
Article dans une revue inserm-01346345 v1

Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage

Fabien Pertuy , Alicia Aguilar , Catherine Strassel-Risser , Anita Eckly , Jean-Noël Freund et al.
Journal of Thrombosis and Haemostasis, 2015, 13 (1), pp.115-125. ⟨10.1111/jth.12784⟩
Article dans une revue hal-03788703 v1
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Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities

Jean-Noël Freund , Isabelle Duluc , Jean-Marie Reimund , Isabelle Gross , Claire Domon-Dell
World Journal of Gastroenterology, 2015, 21 (5), pp.1436-1443. ⟨10.3748/wjg.v21.i5.1436⟩
Article dans une revue hal-03788696 v1

Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate

Morgane Rabineau , Florence Flick , Eric Mathieu , Annie Tu , Bernard Senger et al.
Biomaterials, 2015, 37, pp.144-155. ⟨10.1016/j.biomaterials.2014.10.023⟩
Article dans une revue hal-03811667 v1
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Combined NADPH Oxidase 1 and Interleukin 10 Deficiency Induces Chronic Endoplasmic Reticulum Stress and Causes Ulcerative Colitis-Like Disease in Mice

Xavier Tréton , Eric Pedruzzi , Cécile Guichard , Yannick Ladeiro , Shirin Sedghi et al.
PLoS ONE, 2014, 9 (7), pp.e101669. ⟨10.1371/journal.pone.0101669⟩
Article dans une revue hal-03313755 v1
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TAF4 Inactivation Reveals the 3 Dimensional Growth Promoting Activities of Collagen 6A3

Igor Martianov , Emilie Cler , Isabelle Duluc , Serge Vicaire , Muriel Philipps et al.
PLoS ONE, 2014, 9 (2), pp.e87365. ⟨10.1371/journal.pone.0087365⟩
Article dans une revue hal-03811643 v1

Transcriptional Regulation of the Intestinal Nuclear Bile Acid Farnesoid X Receptor (FXR) by the caudal-related Homeobox 2 (CDX2)

Salvatore Modica , Marica Cariello , Annalisa Morgano , Isabelle Gross , Maria Carmela Vegliante et al.
Journal of Biological Chemistry, 2014, 289 (41), pp.28421-28432. ⟨10.1074/jbc.M114.571513⟩
Article dans une revue hal-03807747 v1
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Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies

Jan de Mey , Jean-Noël Freund
Tissue Barriers, 2013, 1 (2), pp.e24965. ⟨10.4161/tisb.24965⟩
Article dans une revue hal-03792240 v1

Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant

Céline Chéry , Alain Hehn , Nadir Mrabet , Abderrahim Oussalah , Elise Jeannesson et al.
Biochimie, 2013, 95 (5), pp.995-1001. ⟨10.1016/j.biochi.2013.01.022⟩
Article dans une revue hal-01474766 v1

Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2

Lylia Derbal-Wolfrom , Erwan Pencreach , T Saandi , Marc Aprahamian , Elisabeth Martin et al.
Oncogene, 2013, 32 (36), pp.4313-4318. ⟨10.1038/onc.2012.445⟩
Article dans une revue hal-03812783 v1

Contribution of Soft Substrates to Malignancy and Tumor Suppression during Colon Cancer Cell Division

Morgane Rabineau , Leyla Kocgozlu , Denis Dujardin , Bernard Senger , Youssef Haikel et al.
PLoS ONE, 2013, 8 (10), pp.e78468. ⟨10.1371/journal.pone.0078468⟩
Article dans une revue hal-03807780 v1

Immunolabelling of Thin Slices of Mouse Descending Colon and Jejunum

Julien Bellis , Isabelle Duluc , Jean-Noël Freund , Jan de Mey
Bio-protocol , 2013, 3 (20), ⟨10.21769/BioProtoc.942⟩
Article dans une revue hal-03812037 v1

Regulation of the tumor suppressor homeogene Cdx2 by HNF4 alpha in intestinal cancer

T Saandi , F Baraille , Lylia Derbal-Wolfrom , A Cattin , F Benahmed et al.
Oncogene, 2013, 32 (32), pp.3782-3788. ⟨10.1038/onc.2012.401⟩
Article dans une revue hal-03788700 v1

Directing nuclear deformation on micropillared surfaces by substrate geometry and cytoskeleton organization

Florent Badique , Dimitar Stamov , Patricia Davidson , Mathieu Veuillet , Günter Reiter et al.
Biomaterials, 2013, 34 (12), pp.2991-3001. ⟨10.1016/j.biomaterials.2013.01.018⟩
Article dans une revue istex hal-02584491 v1
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Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase

Jean-Louis Guéant , Maatem Caillerez-Fofou , Shyuefang Battaglia-Hsu , Jean-Marc Alberto , Jean-Noël Freund et al.
Biochimie, 2013, 95 (5), pp.1033-1040. ⟨10.1016/j.biochi.2013.01.020⟩
Article dans une revue hal-01704564 v1
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CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness

Bruno Pereira , Sofia Sousa , Rita Barros , Laura Carreto , Patrícia Oliveira et al.
Nucleic Acids Research, 2013, 41 (7), pp.3986 - 3999. ⟨10.1093/nar/gkt087⟩
Article dans une revue hal-02648089 v1

Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and beta-Catenin Activity in Colon Cancer Cells

Isabelle Hinkel , Isabelle Duluc , Elisabeth Martin , Dominique Guenot , Jean-Noël Freund et al.
Gastroenterology, 2012, 142 (4), pp.875-885. ⟨10.1053/j.gastro.2011.12.037⟩
Article dans une revue hal-03788697 v1

Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells

Benjamin Renouf , Christine Soret , Thoueiba Saandi , François Delalande , Elisabeth Martin et al.
Nucleic Acids Research, 2012, 40 (8), pp.3456-3469. ⟨10.1093/nar/gkr1242⟩
Article dans une revue hal-03807892 v1

Gastric intestinal metaplasia revisited: function and regulation of CDX2

Rita Barros , Jean-Noël Freund , Leonor David , Raquel Almeida
Trends in Molecular Medicine, 2012, 18 (9), pp.555-563. ⟨10.1016/j.molmed.2012.07.006⟩
Article dans une revue istex hal-03790027 v1
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Identité et pathologies intestinales : le gène homéotique Cdx2

Jean-Noël Freund
Annales de Pathologie, 2012, 32 (5S), pp.S24-S27. ⟨10.1016/j.annpat.2012.08.005⟩
Article dans une revue hal-03788709 v1

The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity

Leyla Kocgozlu , Morgane Rabineau , Géraldine Koenig , Youssef Haikel , Pierre Schaaf et al.
Biomaterials, 2012, 33 (3), pp.798-809. ⟨10.1016/j.biomaterials.2011.10.024⟩
Article dans une revue istex hal-03811631 v1

Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi

I. Abdallah Hajj Hussein , Jean-Noël Freund , Jean-Marie Reimund , A. Shams , M. Yamine et al.
Journal of Biological Regulators and Homeostatic Agents, 2012, 26 (3), pp.515-526
Article dans une revue hal-03812791 v1

Cdx2 determines the fate of postnatal intestinal endoderm

Emma Stringer , Isabelle Duluc , Thoueiba Saandi , Irwin Davidson , Monika Bialecka et al.
Development (Cambridge, England), 2012, 139 (3), pp.465-474. ⟨10.1242/dev.070722⟩
Article dans une revue hal-03807900 v1

The tumor suppressor gene APC controls planar cell polarities central to gut homeostasis.

Julien Bellis , Isabelle Duluc , Béatrice Romagnolo , Christine Perret , Maree C. Faux et al.
Journal of Cell Biology, 2012, 198, pp.331-341. ⟨10.1083/jcb.201204086⟩
Article dans une revue hal-00740860 v1

Concerted involvement of Cdx / Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone

Cesca van de Ven , Monika Bialecka , Roel Neijts , Teddy Young , Jennifer Rowland et al.
Development (Cambridge, England), 2011, 138 (16), pp.3451-3462. ⟨10.1242/dev.066118⟩
Article dans une revue hal-03807821 v1
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CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype

Rita Barros , Luis Texeira da Mosta , Joao Pinto-De-Sousa , Isabelle Duluc , Jean-Noël Freund et al.
Gut, 2011, 60 (3), pp.290-298. ⟨10.1136/gut.2010.222323⟩
Article dans une revue hal-03788698 v1

Immunohistochemical expression of CDX2, β-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer

Camille Laurent , Magali Svrcek , Jean-François Flejou , Marie-Pierre Chenard , Bernard Duclos et al.
Inflammatory Bowel Diseases, 2011, 17 (1), pp.232-240. ⟨10.1002/ibd.21451⟩
Article dans une revue hal-03811769 v1

NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon

Nicolas Coant , Sanae Ben Mkaddem , Eric Pedruzzi , Cécile Guichard , Xavier Tréton et al.
Molecular and Cellular Biology, 2010, 30 (11), pp.2636-2650. ⟨10.1128/MCB.01194-09⟩
Article dans une revue hal-03796779 v1

Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation

Rita Barros , Vânia Camilo , Bruno Pereira , Jean-Noël Freund , Leonor David et al.
Biochemical Society Transactions, 2010, 38 (2), pp.358-363. ⟨10.1042/BST0380358⟩
Article dans une revue hal-03811611 v1
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CDX2 in Congenital Gut Gastric-Type Heteroplasia and Intestinal-Type Meckel Diverticula

Elisabeth Martin , Marie Vanier , Manuela Tavian , Eric Guerin , Claire Domon-Dell et al.
Pediatrics, 2010, 126 (3), pp.e723-e727. ⟨10.1542/peds.2009-3512⟩
Article dans une revue hal-03789463 v1

Targeted Apc;twist double-mutant mice: A new model of spontaneous osteosarcoma that mimics the human disease

Natacha Entz-Werlé , Philippe Choquet , Agnès Neuville , Sabine Kuchler-Bopp , François Clauss et al.
Translational Oncology, 2010, 3 (6), pp.344-353. ⟨10.1593/tlo.10169⟩
Article dans une revue hal-00591470 v1

Intestinal Lactase as an Autologous β-Galactosidase Reporter Gene for In Vivo Gene Expression Studies

Siamak Salehi , Lorna Eckley , Greta Sawyer , Xiaohong Zhang , Xuebin Dong et al.
Human Gene Therapy, 2009, 20 (1), pp.21-30. ⟨10.1089/hum.2008.101⟩
Article dans une revue hal-03811789 v1

Cdx and Hox Genes Differentially Regulate Posterior Axial Growth in Mammalian Embryos

Teddy Young , Jennifer Elizabeth Rowland , Cesca van de Ven , Monika Bialecka , Ana Novoa et al.
Developmental Cell, 2009, 17 (4), pp.516-526. ⟨10.1016/j.devcel.2009.08.010⟩
Article dans une revue hal-03811755 v1

Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2

S Modica , A Morgano , L Salvatore , M Petruzzelli , M-T Vanier et al.
Gut, 2009, 58 (9), pp.1250-1259. ⟨10.1136/gut.2008.158386⟩
Article dans une revue hal-03813788 v1

Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin.

Laurent Pons , Shyue-Fang Battaglia-Hsu , Carlos Enrique Orozco-Barrios , Sandrine Ortiou , Celine Chery et al.
PLoS ONE, 2009, 4 (7), pp.e6325. ⟨10.1371/journal.pone.0006325⟩
Article dans une revue hal-00559010 v1

Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines

R Barros , B Pereira , I Duluc , M Azevedo , N Mendes et al.
The Journal of pathology and bacteriology, 2008, 215 (4), pp.411-420. ⟨10.1002/path.2369⟩
Article dans une revue istex hal-03313800 v1

Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer

C Bonhomme , A Calon , Elisabeth Martin , S Robine , A Neuville et al.
Oncogene, 2008, 27 (32), pp.4497-4502. ⟨10.1038/onc.2008.78⟩
Article dans une revue hal-03812890 v1

Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors

Xiaohong Lu , Jean-Noël Freund , Marc Muller , Juliette Ravey , Jean-Pierre Nicolas et al.
Biochimie, 2008, 90 (5), pp.697-704. ⟨10.1016/j.biochi.2007.12.002⟩
Article dans une revue istex hal-03811802 v1

Multiple Regulatory Regions Control the Complex Expression Pattern of the Mouse Cdx2 Homeobox Gene

Fairouz Benahmed , Isabelle Gross , Stephen Gaunt , Felix Beck , Frédéric Jehan et al.
Gastroenterology, 2008, 135 (4), pp.1238-1247.e3. ⟨10.1053/j.gastro.2008.06.045⟩
Article dans une revue hal-03811811 v1

Inflammatory bowel disease in rats: Bacterial and chemical interaction

Inaya Abdallah Hajj Hussein , Rania Tohme , Kassem Barada , Mostafa Hassan Mostafa , Jean-Noël Freund et al.
World Journal of Gastroenterology, 2008, 14 (25), pp.4028. ⟨10.3748/wjg.14.4028⟩
Article dans une revue hal-03811622 v1

The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells

Isabelle Gross , Isabelle Duluc , T. Benameur , A. Calon , Elisabeth Martin et al.
Oncogene, 2008, 27 (1), pp.107-115. ⟨10.1038/sj.onc.1210601⟩
Article dans une revue hal-03812788 v1

Precancerous Lesions Upon Sporadic Activation of β-Catenin in Mice

Isabelle Coste , Jean-Noël Freund , Simone Spaderna , Thomas Brabletz , Toufic Renno
Gastroenterology, 2007, 132 (4), pp.1299-1308. ⟨10.1053/j.gastro.2007.01.029⟩
Article dans une revue hal-03045926 v1

Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein.

Alexandre Calon , Isabelle Gross , Irwin Davidson , Michèle Kedinger , Isabelle Duluc et al.
Nucleic Acids Research, 2007, 35 (1), pp.175-85. ⟨10.1093/nar/gkl1034⟩
Article dans une revue hal-00188312 v1

Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice

Philippe Choquet , Alexandre Calon , Élodie Breton , Felix Beck , Claire Domon-Dell et al.
Comptes Rendus. Biologies, 2007, 330 (11), pp.821-827. ⟨10.1016/j.crvi.2007.08.002⟩
Article dans une revue hal-03792413 v1

Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation

A Calon , Isabelle Gross , B Lhermitte , Elisabeth Martin , F Beck et al.
Gut, 2007, 56 (12), pp.1688-1695. ⟨10.1136/gut.2007.125542⟩
Article dans une revue hal-03789487 v1

Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival

Isabelle Gross , Olivier Armant , Soufiane Benosmane , Jose-Luis Gonzalez de Aguilar , Jean-Noël Freund et al.
Cell Death and Differentiation, 2007, 14 (10), pp.1802-1812. ⟨10.1038/sj.cdd.4402188⟩
Article dans une revue hal-03817466 v1

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.

Karine Buchet-Poyau , Julien Courchet , Hervé Le Hir , Bertrand Séraphin , Jean-Yves Scoazec et al.
Nucleic Acids Research, 2007, 35 (4), pp.1289-300. ⟨10.1093/nar/gkm016⟩
Article dans une revue hal-00167447 v1

Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability

Clément Subtil , Eric Guérin , Anne Schneider , Marie-Pierre Chenard , Elisabeth Martin et al.
Cancer Letters, 2007, 247 (2), pp.197-203. ⟨10.1016/j.canlet.2006.04.004⟩
Article dans une revue hal-03811777 v1

The Microenvironment Controls CDX2 Homeobox Gene Expression in Colorectal Cancer Cells

Fairouz Benahmed , Isabelle Gross , Dominique Guenot , Frédéric Jehan , Elisabeth Martin et al.
American Journal of Pathology, 2007, 170 (2), pp.733-744. ⟨10.2353/ajpath.2007.060696⟩
Article dans une revue hal-03788843 v1
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The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells

Nicolas Jonckheere , Audrey Vincent , Michaël Perrais , Marie-Paule Ducourouble , Anita Korteland-van Male et al.
Journal of Biological Chemistry, 2007, ⟨10.1074/jbc.M700905200⟩
Article dans une revue hal-02905844 v1

CDX-2 homeobox gene expression in human gastric carcinoma and precursor lesions

Hyung-Seok Kim , Ji-Shin Lee , Jean-Noël Freund , Kyung-Whan Min , Jeong-Soo Lee et al.
Journal of Gastroenterology and Hepatology, 2006, 21 (2), pp.438-442. ⟨10.1111/j.1440-1746.2005.03933.x⟩
Article dans une revue hal-03812876 v1

Bile Acids Induce Ectopic Expression of Intestinal Guanylyl Cyclase C Through Nuclear Factor-κB and Cdx2 in Human Esophageal Cells

Philip Debruyne , Matthew Witek , Li Gong , Ruth Birbe , Inna Chervoneva et al.
Gastroenterology, 2006, 130 (4), pp.1191-1206. ⟨10.1053/j.gastro.2005.12.032⟩
Article dans une revue hal-03812871 v1

Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.

Isabelle Gross , Benoit Lhermitte , Claire Domon-Dell , Isabelle Duluc , Elisabeth Martin et al.
Oncogene, 2005, 24 (54), pp.7955-63. ⟨10.1038/sj.onc.1208945⟩
Article dans une revue inserm-00157949 v1

Laminin isoforms: biological roles and effects on the intracellular distribution of nuclear proteins in intestinal epithelial cells.

Natacha Turck , Isabelle Gross , Patrick Gendry , Jeanne Stutzmann , Jean-Noël Freund et al.
Experimental Cell Research, 2005, 303 (2), pp.494-503. ⟨10.1016/j.yexcr.2004.10.025⟩
Article dans une revue istex inserm-00158350 v1
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Down-regulation of the Tumor Suppressor PTEN by the Tumor Necrosis Factor-α/Nuclear Factor-κB (NF-κB)-inducing Kinase/NF-κB Pathway Is Linked to a Default IκB-α Autoregulatory Loop

Sunghoon Kim , Claire Domon-Dell , Junghee Kang , Dai Chung , Jean-Noël Freund
Journal of Biological Chemistry, 2004, 279 (6), pp.4285 - 4291. ⟨10.1074/jbc.m308383200⟩
Article dans une revue hal-03789566 v1

Control of differentiation-induced calbindin-D 9k gene expression in Caco-2 cells by cdx-2 and HNF-1α

Liyong Wang , Anna Klopot , Jean-Noel Freund , Jean-Noël Freund , Lauren Dowling et al.
AJP - Gastrointestinal and Liver Physiology, 2004, 287 (5), pp.G943-G953. ⟨10.1152/ajpgi.00121.2004⟩
Article dans une revue hal-03789475 v1

Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer

Sang-Pyo Kim , Jong-Wook Park , Sung-Hee Lee , Jun Hee Lim , Byeong-Churl Jang et al.
Biochemical and Biophysical Research Communications, 2004, 315 (1), pp.93-99. ⟨10.1016/j.bbrc.2004.01.020⟩
Article dans une revue hal-03811713 v1
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SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes.

Philippe Blache , Marc van de Wetering , Isabelle Duluc , Claire Domon , Philippe Berta et al.
Journal of Cell Biology, 2004, 166 (1), pp.37-47. ⟨10.1083/jcb.200311021⟩
Article dans une revue hal-00266987 v1
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Klotho Is a Novel β-Glucuronidase Capable of Hydrolyzing Steroid β-Glucuronides

Osamu Tohyama , Akihiro Imura , Akiko Iwano , Jean-Noël Freund , Bernard Henrissat et al.
Journal of Biological Chemistry, 2004, 279 (11), pp.9777 - 9784. ⟨10.1074/jbc.m312392200⟩
Article dans une revue hal-03792399 v1

Down-Regulation of the Homeodomain Factor Cdx2 in Colorectal Cancer by Collagen Type I

Thomas Brabletz , Simone Spaderna , Jochen Kolb , Falk Hlubek , Gerhard Faller et al.
Cancer Research, 2004, 64 (19), pp.6973-6977. ⟨10.1158/0008-5472.CAN-04-1132⟩
Article dans une revue hal-03813556 v1

Cdx1 homeobox gene during human colon cancer progression

Claire Domon-Dell , Anne Schneider , Virginie Moucadel , Eric Guerin , Dominique Guenot et al.
Oncogene, 2003, 22 (39), pp.7913-7921. ⟨10.1038/sj.onc.1206756⟩
Article dans une revue hal-03812880 v1

Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2

Amandine Gautier-Stein , Claire Domon-Dell , Alexandre Calon , Isabelle Baly , Jean-Noël Freund et al.
Nucleic Acids Research, 2003, 31 (18), pp.5238-5246. ⟨10.1093/nar/gkg747⟩
Article dans une revue hal-03813522 v1

Cancer colorectal au cours de la rectocolite hémorragique

Jean-Marie Reimund , Camille Laurent , Marie Pierrette Chenard , Jean-Pierre Bellocq , Jean-Noël Freund et al.
Hépato-Gastro, 2003, 6 (10), pp.415-423
Article dans une revue hal-03812785 v1

The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development

C Bonhomme , Isabelle Duluc , E Martin , K Chawengsaksophak , Marie Pierrette Chenard et al.
Gut, 2003, 52 (10), pp.1465-1471. ⟨10.1136/gut.52.10.1465⟩
Article dans une revue hal-03797013 v1

Endoderm- and mesenchyme-dependent commitment of the differentiated epithelial cell types in the developing intestine of rat

Christelle Ratineau , Isabelle Duluc , Céline Pourreyron , Michèle Kedinger , Jean-Noël Freund et al.
Differentiation, 2003, 71 (2), pp.163-169. ⟨10.1046/j.1432-0436.2003.t01-1-710203.x⟩
Article dans une revue hal-03813756 v1

Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

Eek-Hoon Jho , Tong Zhang , Claire Domon , Choun-Ki Joo , Jean-Noël Freund et al.
Molecular and Cellular Biology, 2002, 22 (4), pp.1172-1183. ⟨10.1128/MCB.22.4.1172-1183.2002⟩
Article dans une revue hal-03788855 v1

The homeobox gene Cdx1 belongs to the p53-p21(WAF)-Bcl-2 network in intestinal epithelial cells

Virginie Moucadel , Maria Serena Totaro , Claire Domon-Dell , Philippe Soubeyran , Jean Charles Dagorn et al.
Biochemical and Biophysical Research Communications, 2002, 297 (3), pp.607-615. ⟨10.1016/s0006-291x(02)02250-7⟩
Article dans une revue hal-03812793 v1

Stimulation of Cdx1 by oncogenic β-catenin/Tcf4 in colon cancer cells; opposite effect of the CDX2 homeoprotein

Claire Domon-Dell , Jean-Noël Freund
FEBS Letters, 2002, 518 (1-3), pp.83-87. ⟨10.1016/s0014-5793(02)02650-9⟩
Article dans une revue hal-03791635 v1

PTEN and TNF-α regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-κB–dependent pathway

Sunghoon Kim , Claire Domon-Dell , Qingding Wang , Dai Chung , Antonio Di Cristofano et al.
Gastroenterology, 2002, 123 (4), pp.1163-1178. ⟨10.1053/gast.2002.36043⟩
Article dans une revue hal-03817213 v1

Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells

Claire Domon-Dell , Q Wang , S Kim , Michèle Kedinger , B M Evers et al.
Gut, 2002, 50 (4), pp.525-529. ⟨10.1136/gut.50.4.525⟩
Article dans une revue hal-03796863 v1

Differentially expressed endoderm and mesenchyme genes along the fetal rat intestine

Isabelle Duluc , C. Hoff , Michèle Kedinger , Jean-Noël Freund
Genesis - The Journal of Genetics and Development, 2001, 29 (2), pp.55-59
Article dans une revue hal-03812797 v1

Functional Interference between Thyroid Hormone Receptor α (TRα) and Natural Truncated TRΔα Isoforms in the Control of Intestine Development

Michelina Plateroti , Karine Gauthier , Claire Domon-Dell , Jean-Noël Freund , Jacques Samarut et al.
Molecular and Cellular Biology, 2001, 21 (14), pp.4761-4772. ⟨10.1128/MCB.21.14.4761-4772.2001⟩
Article dans une revue hal-03791255 v1

Aspects cellulaires et molécuaires du développemet intestinal

Jean-Noël Freund
Hépato-Gastro, 2000, 1 (7), pp.47-56
Article dans une revue hal-03814378 v1

Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine

H. Lickert , Claire Domon , G. Huls , C. Wehrle , Isabelle Duluc et al.
Development (Cambridge, England), 2000, 127 (17), pp.3805-3813
Article dans une revue hal-03812792 v1

Production of low-lactose milk by ectopic expression of intestinal lactase in the mouse mammary gland

Bernard Jost , Jean-Luc Vilotte , Isabelle Duluc , Jean-Luc Rodeau , Jean-Noël Freund
Nature Biotechnology, 1999, 17, pp.160-164
Article dans une revue hal-02696428 v1

Involvement of T3Rα- and β-receptor subtypes in mediation of T3 functions during postnatal murine intestinal development☆, ☆☆, ★

Michelina Plateroti , Olivier Chassande , Alexandre Fraichard , Karine Gauthier , Jean-Noël Freund et al.
Gastroenterology, 1999, 116 (6), pp.1367-1378. ⟨10.1016/S0016-5085(99)70501-9⟩
Article dans une revue istex hal-03818728 v1

Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras

Olivier Lorentz , Axelle Cadoret , Isabelle Duluc , Jacqueline Capeau , Christian Gespach et al.
Oncogene, 1999, 18 (1), pp.87-92. ⟨10.1038/sj.onc.1202280⟩
Article dans une revue hal-03812197 v1

Prédigestion d'un composant du lait, le lactose, dans la glande mammaire

Jean-Noël Freund
Médecine/Sciences, 1999, 15 (8-9), pp.1058-1059. ⟨10.4267/10608/1487⟩
Article dans une revue hal-03817261 v1

Promotion of intestinal carcinogenesis by dietary methionine

B. Duranton , Jean-Noël Freund , M. Galluser , R. Schleiffer , F. Gossé et al.
Carcinogenesis, 1999, 20 (3), pp.493-497
Article dans une revue hal-03812799 v1

Intestinal Epithelial-Mesenchymal Cell Interactions

Michèle Kedinger , Isabelle Duluc , C. Fritsch , O. Lorentz , M. Plateroti et al.
Annals of the New York Academy of Sciences, 1998, 859 (1 INTESTINAL PL), pp.1-17. ⟨10.1111/j.1749-6632.1998.tb11107.x⟩
Article dans une revue hal-03814869 v1

The Cdx-1 and Cdx-2 homeobox genes in the intestine

Jean-Noël Freund , Claire Domon-Dell , Michèle Kedinger , Isabelle Duluc
Biochemistry and Cell Biology, 1998, 76 (6), pp.957-969. ⟨10.1139/o99-001⟩
Article dans une revue hal-03817632 v1

Subepithelial fibroblast cell lines from different levels of gut axis display regional characteristics

Michelina Plateroti , D. C. Rubin , Isabelle Duluc , R. Singh , C. Foltzer-Jourdainne et al.
American Journal of Physiology, 1998, 274 (5 Pt 1)
Article dans une revue hal-03812790 v1

Cellular and molecular partners involved in gut morphogenesis and differentiation

Michèle Kedinger , O. Lefebvre , Isabelle Duluc , Jean-Noël Freund , Patricia Simon-Assmann
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (1934–1990), 1998, 353 (1370), pp.847-856. ⟨10.1098/rstb.1998.0249⟩
Article dans une revue hal-03813452 v1

Lactase is unchanged in suckling mice fed with lactose-free milk

Bernard Jost , Isabelle Duluc , Jean-Luc Vilotte , Jean-Noël Freund
Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology, 1998, 22, pp.863-867
Article dans une revue hal-02690133 v1

Key Role of the Cdx2 Homeobox Gene in Extracellular Matrix–mediated Intestinal Cell Differentiation

Olivier Lorentz , Isabelle Duluc , Adèle De Arcangelis , Patricia Simon-Assmann , Michèle Kedinger et al.
Journal of Cell Biology, 1997, 139 (6), pp.1553-1565. ⟨10.1083/jcb.139.6.1553⟩
Article dans une revue hal-03791318 v1

Identification of homologues of the mammalian intestinal lactase gene in non-mammals (birds and molluscs)

Jean-Noël Freund , Bernard Jost , Olivier Lorentz , Isabelle Duluc
Biochemical Journal, 1997, 322 (2), pp.491-498. ⟨10.1042/bj3220491⟩
Article dans une revue hal-03791310 v1

Mesenchyme-mediated effects of retinoic acid during rat intestinal development

M. Plateroti , Jean-Noël Freund , C. Leberquier , Michèle Kedinger
Journal of Cell Science, 1997, 110 ( Pt 10), pp.1227-1238
Article dans une revue hal-03812798 v1

Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells

Isabelle Duluc , Olivier Lorentz , Christine Fritsch , Cathy Leberquier , Michèle Kedinger et al.
Journal of Cell Science, 1997, 110 ( Pt 11), pp.1317-1324. ⟨10.1242/jcs.110.11.1317⟩
Article dans une revue hal-03812787 v1

Functional diversity and interactions between the repeat domains of rat intestinal lactase

Bernard Jost , Isabelle Duluc , Melville Richardson , Richard Lathe , Jean-Noël Freund
Biochemical Journal, 1997, 327 (1), pp.95-103. ⟨10.1042/bj3270095⟩
Article dans une revue hal-03791201 v1

Verification of the lactase site of rat lactase-phlorizin hydrolase by site-directed mutagenesis

Adriana Neele , Alexandra W.C. Einerhand , Jan Dekker , Hans Büller , Jean-Noël Freund et al.
Gastroenterology, 1995, 109 (4), pp.1234-1240. ⟨10.1016/0016-5085(95)90583-9⟩
Article dans une revue hal-03812281 v1

Activity of the rat lactase gene promoter in transfected human colon cancer cells

R. Boukamel , P. Neuville , Isabelle Duluc , Jean-Noël Freund
Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie, 1995, 318 (11), pp.1133-1140
Article dans une revue hal-03814373 v1

Ultrastructural study of intestinal lactase gene expression

Jean-Noël Freund , Bernard Jost , Isabelle Duluc , G. Morel
Biology of the Cell, 1995, 83 (2-3), pp.211-217
Article dans une revue hal-03812800 v1

Fetal endoderm primarily holds the temporal and positional information required for mammalian intestinal development.

Isabelle Duluc , Jean-Noël Freund , C Leberquier , Michèle Kedinger
Journal of Cell Biology, 1994, 126 (1), pp.211-221. ⟨10.1083/jcb.126.1.211⟩
Article dans une revue hal-03789578 v1

The cis -element CE-LPH1 of the rat intestinal lactase gene promoter interacts in vitro with several nuclear factors present in endodermal tissues

Rita Boukamel , Jean-Noël Freund
FEBS Letters, 1994, 353 (1), pp.108-112. ⟨10.1016/0014-5793(94)01026-9⟩
Article dans une revue hal-03788837 v1

Precocious and reversible expression of sucrase-isomaltase unrelated to intestinal cell turnover

E. Nsi-Emvo , C. Foltzer-Jourdainne , Francis Raul , F. Gosse , Isabelle Duluc et al.
AJP - Gastrointestinal and Liver Physiology, 1994, 266 (4), pp.G568-G575. ⟨10.1152/ajpgi.1994.266.4.G568⟩
Article dans une revue hal-03812230 v1

Multiple levels of control of the stage- and region-specific expression of rat intestinal lactase.

Isabelle Duluc , Bernard Jost , Jean-Noël Freund
Journal of Cell Biology, 1993, 123 (6), pp.1577-1586. ⟨10.1083/jcb.123.6.1577⟩
Article dans une revue hal-03792443 v1

Gradient expression of Cdx along the rat intestine throughout postnatal development

Jean-Noël Freund , Rita Boukamel , Aziz Benazzouz
FEBS Letters, 1992, 314 (2), pp.163-166. ⟨10.1016/0014-5793(92)80965-j⟩
Article dans une revue hal-03788821 v1

Dietary control of the lactase mRNA distribution along the rat small intestine

Isabelle Duluc , M. Galluser , Francis Raul , Jean-Noël Freund
American Journal of Physiology, 1992, 262 (6 Pt 1)
Article dans une revue hal-03814382 v1

The rat LPH Gene 5′ region: comparative structure with the human gene

Rita Boukamel , Jean-Noël Freund
DNA Sequence, 1992, 3 (2), pp.119-121. ⟨10.3109/10425179209034006⟩
Article dans une revue hal-03817641 v1

Do co-translated product(s) of lactase-phlorizin hydrolase accumulate in the rat intestine?

Jean-Noël Freund
Cellular and Molecular Biology, 1992, 38 (7), pp.713-718
Article dans une revue hal-03814375 v1

Rat lactase activity and mRNA expression in relation to the thyroid and corticoid status

Jean-Noël Freund , C. Foltzer-Jourdainne , Isabelle Duluc , M. Galluser , F. Gosse et al.
Cellular and Molecular Biology, 1991, 37 (4), pp.463-466
Article dans une revue hal-03818491 v1

Derivatives of Plant Beta-GIucans Are Hydrolyzed by Intestinal Lactase-Phlorizin Hydrolase of Mammals

Jean-Noël Freund , Francine Gossé
Enzyme Protein, 1991, 45 (1-2), pp.71-74. ⟨10.1159/000468868⟩
Article dans une revue hal-03813472 v1

Sequence of the precursor of intestinal lactase-phlorizin hydrolase from fetal rat

Isabelle Duluc , Rita Boukamel , Ned Mantei , Giorgio Semenza , Francis Raul et al.
Gene, 1991, 103 (2), pp.275-276. ⟨10.1016/0378-1119(91)90286-K⟩
Article dans une revue hal-03817319 v1

Adaptation of intestinal hydrolases to starvation in rats: effect of thyroid function

M. Galluser , R. Belkhou , Jean-Noël Freund , Isabelle Duluc , N. Torp et al.
Journal of Comparative Physiology B, 1991, 161 (4), pp.357-361. ⟨10.1007/BF00260793⟩
Article dans une revue istex hal-03812789 v1

Lactase expression is controlled differently in the jejunum and ileum during development in rats

Jean-Noël Freund , Francis Raul , Isabelle Duluc
Gastroenterology, 1991, 100 (2), pp.388-394. ⟨10.5555/uri:pii:0016508591902072⟩
Article dans une revue hal-03818483 v1

Type IV collagen mRNA accumulates in the mesenchymal compartment at early stages of murine developing intestine.

P Simon-Assmann , F Bouziges , Jean-Noël Freund , F Perrin-Schmitt , Michèle Kedinger
Journal of Cell Biology, 1990, 110 (3), pp.849-857. ⟨10.1083/jcb.110.3.849⟩
Article dans une revue hal-03788848 v1

Different expression of the mRNA detected by the cDNA for fetal rat lactase in the jejunum and colon

Isabelle Duluc , Jean-Noël Freund , N. Mantei , Francis Raul
Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology, 1990, 14 (8-9), pp.635-640
Article dans une revue hal-03817670 v1

Specific expression of lactase in the jejunum and colon during postnatal development and hormone treatments in the rat

Jean-Noël Freund , Isabelle Duluc , C Foltzer-Jourdainne , F Gosse , Francis Raul
Biochemical Journal, 1990, 268 (1), pp.99-103. ⟨10.1042/bj2680099⟩
Article dans une revue hal-03796808 v1

Comparative expression of the mRNA for three intestinal hydrolases during postnatal development in the rat

Jean-Noël Freund , N. Torp , Isabelle Duluc , C. Foltzer-Jourdainne , M. Danielsen et al.
Cellular and Molecular Biology, 1990, 36 (6), pp.729-736
Article dans une revue hal-03814379 v1

Discrepancy between the intestinal lactase enzymatic activity and mRNA accumulation in sucklings and adults Effect of starvation and thyroxine treatment

Jean-Noël Freund , Isabelle Duluc , Francis Raul
FEBS Letters, 1989, 248 (1-2), pp.39-42. ⟨10.1016/0014-5793(89)80427-2⟩
Article dans une revue hal-03790118 v1

The gene for intestinal sucrase-isomaltase as member of a gene family

Jean-Noël Freund , R. Heilig , N. Lehner , Francis Raul
Cellular and Molecular Biology, 1989, 35 (3), pp.313-324
Article dans une revue hal-03818484 v1

Synthetic probes to investigate the genetic arrangement of the coding sequences involved in the pyrimidine pathway over the phylogenesis

Jean-Noël Freund , Bruno Jarry
Life Science Advance Molecular Genetics, 1988, 7, pp.1-5
Article dans une revue hal-03812795 v1

The rudimentary gene of Drosophila melanogaster encodes four enzymic functions

Jean-Noël Freund , B.P. Jarry
Journal of Molecular Biology, 1987, 193 (1), pp.1-13. ⟨10.1016/0022-2836(87)90621-8⟩
Article dans une revue hal-03817643 v1

Molecular organization of the rudimentary gene of Drosophila melanogaster

Jean-Noël Freund , W. Vergis , P. Schedl , B.P. Jarry
Journal of Molecular Biology, 1986, 189 (1), pp.25-36. ⟨10.1016/0022-2836(86)90378-5⟩
Article dans une revue hal-03817199 v1

Organization of transcription units around the Drosophila melanogaster rudimentary locus and temporal pattern of expression

J. Rawls , Jean-Noël Freund , B. Jarry , C. Louis , W. Segraves et al.
Molecular and General Genetics MGG, 1986, 202 (3), pp.493-499. ⟨10.1007/BF00333283⟩
Article dans une revue hal-03817202 v1

Mucdhl, a typical cadherin that decreases in type from colon "cancer stem cell" and inhibits the beta-catenin of unconventional way

M. Baranger , Georg Mellitzer , L Marisa , Elisabeth Martin , Isabelle Duluc et al.
2ème Congrès de la SFC, Société Française du Cancer, Jun 2015, Paris, France. pp.127-128
Communication dans un congrès hal-04801443 v1

Tu1986 The Cadherin-Related Mucdhl Is Decreased in Stem Cell-Like Colon Tumors and Inhibits β-Catenin Signaling in a Non-Classical Way

Mathilde Baranger , Georg Mellitzer , Laetitia Marisa , Elisabeth Martin , Isabelle Duluc et al.
DDW2015, Digestive Disease Week, Washington, USA, 16-19 Mai 2015, May 2015, Washington, United States. pp.S-953, ⟨10.1016/S0016-5085(15)33252-2⟩
Communication dans un congrès hal-04801235 v1

New Insight in Inflammatory Bowel Disease Pathophysiology: Current and Future Therapeutic Applications

Jean-Marie Reimund , Jean-Noël Freund , Bernard Duclos
American Association of Anatomist; Annual Meeting 2015, Mar 2015, Boston, United States
Communication dans un congrès hal-04801669 v1

Evidence for non-hematopoietic Cre activity in Pf4-Cre mice

Fabien Pertuy , Catherine Strassel , Anita Eckly , Jean-Noël Freund , Isabelle Duluc et al.
XXIV Congress of the ISTH, International Society on Thrombosis and Haemostasis, Jun 2013, Amsterdam, Netherlands
Communication dans un congrès hal-04801261 v1

P003 Selective inhibition of eIF2alpha dephosphorylation prevents colitis and shows therapeutic potential in a new model of ulcerative colitis

X. Treton , E. Pedruzzi , C. Guichard , M. Vallee , S. Sedghi et al.
DDW2013, Digestive Disease Week, May 2013, Orlando, United States. pp.S12, ⟨10.1016/S1873-9946(13)60026-4⟩
Communication dans un congrès hal-04801558 v1

Su1866 The CDx2 Homeoprotein Inhibits DNA Repair by Non-Homologous End Joining Specifically in Colon Cancer but Not in Leukemia Cells

Benjamin Renouf , Christine Soret , Thoueiba Saandi , François Delalande , Elisabeth Martin et al.
DDW2012, Digestive Disease Week, May 2012, San Diego, United States. pp.S-522, ⟨10.1016/s0016-5085(12)62005-8⟩
Communication dans un congrès hal-03811655 v1

Levels and Factors of Control of Small-Intestinal Lactase Expression in the Laboratory Rat

Jean-Noël Freund , R. Boukamel , Isabelle Duluc
2nd International Symposium on Common Food Intolerances: Health Risks due to Lack or Consumption of Milk in Human Nutrition and Adult-Type Hypolactasia, Capri, October 1992, Oct 1992, Capri, Italy
Communication dans un congrès hal-03818485 v1

Inflammatory Bowel Disease-Associated Cancer

Jean-Marie Reimund , Jean-Noël Freund
Encyclopedia of Cancer, Springer Berlin Heidelberg, pp.2258-2263, 2017, ⟨10.1007/978-3-662-46875-3_3046⟩
Chapitre d'ouvrage hal-03812029 v1

Ulcerative Colitis-Associated Colorectal Cancer Prevention by 5-Aminosalicylates: Current Status and Perspectives

Jean-Marie Reimund , Marion Tavernier , Stephanie Viennot , Inaya Abdallah Hajj Hussein , Benoit Dupont et al.
Ulcerative Colitis from Genetics to Complications, InTech, 2012, ⟨10.5772/25577⟩
Chapitre d'ouvrage hal-02461233 v1

Inflammatory Bowel Disease-associated Cancer

Jean-Marie Reimund , Jean-Noël Freund
Manfred Schwab. Encyclopedia of Cancer, Springer Berlin Heidelberg, pp.1525-1528, 2008, 978-3-540-36847-2
Chapitre d'ouvrage hal-03814374 v1

Cell interactions through the basement membrane in intestinal development and differentiation

Michèle Kedinger , Jean-Noël Freund , J. F. Launay , Patricia Simon-Assmann , I. R. Sanderson et al.
Development of the gastrointestinal tract, pp.83-102, 2000
Chapitre d'ouvrage hal-03814377 v1

Homeobox genes and intestinal development

Claire Domon-Dell , Isabelle Duluc , Michèle Kedinger , Jean-Noël Freund
Cytokines and Cell Homeostasis in the Gastroinstestinal Tract, 113, Springer, pp.72-81, 2000, 978-0-7923-8758-9
Chapitre d'ouvrage hal-03812794 v1

Regulation of the epithelial-mesenchymal cross-talk in the gut

Michèle Kedinger , J. Olsen , C. Fritsch , Patricia Simon-Assmann , Jean-Noël Freund
Intestinal Mucosa and its Diseases - Pathophysiology and Clinics, 110, Springer, 1999, 978-0-7923-8754-1
Chapitre d'ouvrage hal-03812796 v1

Cellular and molecular mechanisms regulating intestinal development

Michèle Kedinger , M. Plateroti , V. Orian-Rousseau , O. Lorentz , C. Fritsch et al.
Cellular and molecular mechanisms regulating intestinal development, 94, Springer, 1997, 978-0-7923-8726-8
Chapitre d'ouvrage hal-03814376 v1

Gut epithelium

Michèle Kedinger , Jean-Noël Freund
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine, 2005, pp.736-739
Autre publication scientifique hal-03812786 v1