Gabriel Ichim

Publications

Pré-publication, Document de travail (3)

Lysosomal MLKL is balanced by ESCRT to control cell death Catherine Jamard,Clara Gil,Marie Castets,Gabriel Ichim,Kathrin Weber 2025 Pré-publication, Document de travail hal-05008890v1
Kremen1 dependence receptor induces SEC24C- and ATG9A-dependent autophagic cell death Sonia Brahim,Thomas Schott,Shiva Ghasemi,Ana Negulescu,Clara Genesteet al. 2025 Pré-publication, Document de travail hal-05008943v1
Targeting the cell and non-cell autonomous regulation of 47S synthesis by GCN2 in colon cancer Marie Piecyk,Mouna Triki,Pierre-Alexandre Laval,Cedric Duret,Joelle Fauvreet al. 2025 Pré-publication, Document de travail hal-05008872v1

Article dans une revue (32)

Atypical contribution of caspase-3 to melanoma cancer cell motility by regulation of coronin 1B activity Kevin Berthenet,Serena Diazzi,Catherine Jamard,Kinga Stopa,Clara Gilet al. Cell Death and Disease, 2025, 16 (1), pp.690. ⟨10.1038/s41419-025-07952-y⟩ Article dans une revue hal-05008919v1
Discovery of KDX1381, a Bivalent CK2α Inhibitor for the Treatment of Solid Tumors as a Single Agent or in Combination Léna Marlhoux,Alexandre Arnaud,Céline Hervieu,Gabriela Makulyte,Charlotte Martinassoet al. Journal of Medicinal Chemistry, 2025, ⟨10.1021/acs.jmedchem.5c00695⟩ Article dans une revue hal-05112011v1
Optogenetically controlled inflammasome activation demonstrates two phases of cell swelling during pyroptosis Julien Nadjar,Sylvain Monnier,Estelle Bastien,Anne-Laure Huber,Christiane Oddouet al. Science Signaling, 2024, 17 (833), pp.eabn8003. ⟨10.1126/scisignal.abn8003⟩ Article dans une revue hal-04567594v1
Spatial sequestration of activated-caspase 3 in aggresomes mediates resistance of neuroblastoma cell to bortezomib treatment Kévin Berthenet,Eliézer Aïmontché,Sara El Mrini,Johan Brière,Nathalie Pionet al. Scientific Reports, 2024, 14, ⟨10.1038/s41598-024-54140-7⟩ Article dans une revue hal-04482149v1
Shedding light on mitochondrial outer-membrane permeabilization and membrane potential: State of the art methods and biosensors Nikolay Popgeorgiev,Clara Gil,Kevin Berthenet,Giulia Bertolin,Gabriel Ichim Seminars in Cell and Developmental Biology, 2024, 156, pp.58-65. ⟨10.1016/j.semcdb.2023.07.003⟩ Article dans une revue hal-04165504v1
The stress sensor GCN2 differentially controls ribosome biogenesis in colon cancer according to the nutritional context Marie Piecyk,Mouna Triki,Pierre‐alexandre Laval,Cedric Duret,Joelle Fauvreet al. Molecular Oncology, 2024, 18 (9), pp.2111-2135. ⟨10.1002/1878-0261.13491⟩ Article dans une revue hal-04235180v1
Hepatocellular carcinoma hosts cholinergic neural cells and tumoral hepatocytes harboring targetable muscarinic receptors Charlotte Hernandez,Claire Verzeroli,Armando Andres Roca Suarez,Abud Jose Farca Luna,Laurie Tononet al. JHEP Reports Innovation in Hepatology, 2024, 7 (1), pp.101245. ⟨10.1016/j.jhepr.2024.101245⟩ Article dans une revue hal-04876113v1
BCL-2 proteins in senescence: beyond a simple target for senolysis? Nadine Martin,Nikolay Popgeorgiev,Gabriel Ichim,David Bernard Nature Reviews Molecular Cell Biology, 2023, 24 (8), pp.517-518. ⟨10.1038/s41580-023-00594-y⟩ Article dans une revue hal-04182726v1
Live-cell imaging and mathematical analysis of the “community effect” in apoptosis Diane Coursier,David Coulette,Hélène Leman,Emmanuel Grenier,Gabriel Ichim Apoptosis, 2023, ⟨10.1007/s10495-022-01783-4⟩ Article dans une revue hal-03821641v1
Live-cell imaging and mathematical analysis of the “community effect” in apoptosis Diane Coursier,David Coulette,Hélène Leman,Emmanuel Grenier,Gabriel Ichim Apoptosis, 2022, 28 (3-4), pp.326-334. ⟨10.1007/s10495-022-01783-4⟩ Article dans une revue hal-04826196v1
Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness Deborah Fanfone,Zhichong Wu,Jade Mammi,Kevin Berthenet,David Neveset al. eLife, 2022, 11, ⟨10.7554/eLife.73150⟩ Article dans une revue hal-03612321v1
Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse Aladin Haimovici,Christoph Höfer,Mohamed Tarek Badr,Elham Bavafaye Haghighi,Tarek Ameret al. Cell Death and Disease, 2022, 13 (4), pp.315. ⟨10.1038/s41419-022-04768-y⟩ Article dans une revue hal-03667748v1
Measuring Nonapoptotic Caspase Activity with a Transgenic Reporter in Mice P. Nicholls,Thomas Pack,Nikhil Urs,Sunil Kumar,Yang Zhouet al. eNeuro, 2022, 9 (5), pp.ENEURO.0147-21.2022. ⟨10.1523/ENEURO.0147-21.2022⟩ Article dans une revue hal-04005711v1
Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network Gabriel Ichim,Benjamin Gibert,Sahil Adriouch,Catherine Brenner,Nathalie Davoustet al. Biomolecules, 2022, 12 (7), pp.901. ⟨10.3390/biom12070901⟩ Article dans une revue hal-03711790v1
Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage Kai Cao,Joel Riley,Rosalie Heilig,Alfredo Montes-Gómez,Esmee Vringeret al. Developmental Cell, 2022, ⟨10.1016/j.devcel.2022.03.019⟩ Article dans une revue hal-03667751v1
Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics Anna Koessinger,Catherine Cloix,Dominik Koessinger,Dieter Henrik Heiland,Florian Bocket al. Cell Death and Differentiation, 2022, 29 (10), pp.2089-2104. ⟨10.1038/s41418-022-01001-3⟩ Article dans une revue hal-03863787v1
Blockade of Platelet CysLT1R Receptor with Zafirlukast Counteracts Platelet Protumoral Action and Prevents Breast Cancer Metastasis to Bone and Lung Lou Saier,Johnny Ribeiro,Thomas Daunizeau,Audrey Houssin,Gabriel Ichimet al. International Journal of Molecular Sciences, 2022, 23 (20), pp.12221. ⟨10.3390/ijms232012221⟩ Article dans une revue inserm-03847792v1
Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma Marie-Anaïs Locquet,Gabriel Ichim,Joseph Bisaccia,Aurelie Dutour,Serge Lebecqueet al. Scientific Reports, 2021, 11 (1), pp.10609. ⟨10.1038/s41598-021-89793-1⟩ Article dans une revue hal-03625041v1
Apoptosis – Fueling the oncogenic fire Camila Castillo Ferrer,Kevin Berthenet,Gabriel Ichim FEBS Journal, 2021, 288 (15), pp.4445-4463. ⟨10.1111/febs.15624⟩ Article dans une revue hal-03624981v1
Low biological fluctuation of mitochondrial CpG and non-CpG methylation at the single-molecule level Chloe Goldsmith,Jesús Rafael Rodríguez-Aguilera,Ines El-Rifai,Adrien Jarretier-Yuste,Valérie Hervieuet al. Scientific Reports, 2021, 11 (1), pp.8032. ⟨10.1038/s41598-021-87457-8⟩ Article dans une revue hal-03625031v1
Blocking SHH/Patched Interaction Triggers Tumor Growth Inhibition through Patched-Induced Apoptosis Pierre-Antoine Bissey,Pauline Mathot,Catherine Guix,Mélissa Jasmin,Isabelle Goddardet al. Cancer Research, 2020, 80 (10), pp.1970-1980. ⟨10.1158/0008-5472.CAN-19-1340⟩ Article dans une revue hal-03102147v1
Sometimes even apoptosis fails: implications for cancer Kevin Berthenet,Kathrin Weber,Gabriel Ichim Molecular & Cellular Oncology, 2020, 7 (6), pp.1797430. ⟨10.1080/23723556.2020.1797430⟩ Article dans une revue hal-03624990v1
TAT-RasGAP 317-326 kills cells by targeting inner-leaflet–enriched phospholipids Marc Serulla,Gabriel Ichim,Filip Stojceski,Gianvito Grasso,Sergii Afoninet al. Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (50), pp.31871-31881. ⟨10.1073/pnas.2014108117⟩ Article dans une revue hal-03415318v1
Profiling Anti-Apoptotic BCL-xL Protein Expression in Glioblastoma Tumorspheres Deborah Fanfone,Ahmed Idbaih,Jade Mammi,Mathieu Gabut,Gabriel Ichim Cancers, 2020, 12 (10), pp.2853. ⟨10.3390/cancers12102853⟩ Article dans une revue hal-03613078v1
CDYL2 Epigenetically Regulates MIR124 to Control NF-kB/STAT3-Dependent Breast Cancer Cell Plasticity Maha Siouda,Audrey D Dujardin,Laetitia Barbollat-Boutrand,Marco Mendoza-Parra,Benjamin Gibertet al. iScience, 2020, 23 (6), pp.101141. ⟨10.1016/j.isci.2020.101141⟩ Article dans une revue hal-02956108v1
In Cellulo Evaluation of the Therapeutic Potential of NHC Platinum Compounds in Metastatic Cutaneous Melanoma Elsa Charignon,Mathilde Bouché,Caroline Clave-Darcissac,Georges Dahm,Gabriel Ichimet al. International Journal of Molecular Sciences, 2020, 21 (21), pp.7826. ⟨10.3390/ijms21217826⟩ Article dans une revue hal-03011335v1
Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness Kevin Berthenet,Camila Castillo Ferrer,Deborah Fanfone,Nikolay Popgeorgiev,David Neveset al. Cell Reports, 2020, 31 (10), pp.107731. ⟨10.1016/j.celrep.2020.107731⟩ Article dans une revue hal-02999426v1
Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth Marie Ménard,Clélia Costechareyre,Gabriel Ichim,Jonathan Blachier,David Neveset al. PLoS Biology, 2018, 16 (5), pp.e2002912. ⟨10.1371/journal.pbio.2002912⟩ Article dans une revue inserm-02137893v1
The Dependence Receptor TrkC Triggers Mitochondria-Dependent Apoptosis upon Cobra-1 Recruitment Gabriel Ichim,Anne-Laure Genevois,Marie Ménard,Li-Ying Yu,Juliana m. Coelho-Aguiaret al. Molecular Cell, 2013, 51 (5), pp.632-646. ⟨10.1016/j.molcel.2013.08.021⟩ Article dans une revue hal-02360899v1
Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Stephen w.G. Tait,Andrew Oberst,Giovanni Quarato,Sandra Milasta,Martina Halleret al. Cell Reports, 2013, 5 (4), pp.438-41. ⟨10.1016/j.celrep.2013.10.034⟩ Article dans une revue pasteur-01384556v1
Neurotrophins and cell death Gabriel Ichim,Servane Tauszig-Delamasure,Patrick Mehlen Experimental Cell Research, 2012, 318 (11), pp.1221-1228. ⟨10.1016/j.yexcr.2012.03.006⟩ Article dans une revue istex hal-02360903v1
Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis. Jimena Bouzas-Rodriguez,Jorge Ruben Cabrera,Céline Delloye-Bourgeois,Gabriel Ichim,Jean-Guy Delcroset al. Journal of Clinical Investigation, 2010, 120 (3), pp.850-8. ⟨10.1172/JCI41013⟩ Article dans une revue hal-00475272v1

Communication dans un congrès (2)

OA02.01 Selective Translation of PBK (PDZ-Binding Kinase) is a Novel Mechanism of Drug Tolerance to Targeted Therapies in EGFR-Mutant Lung Cancer Camille Léonce,Anne-Laure Desage,Nour El-Houda Mourksi,Geneviève de Souza,Béatrice Vanbervlietet al. IASLC 2024 Hot Topic in Basic and Translational Science Meeting: Tolerance and Resistance to Targeted Therapy in Non-Small Cell Lung Cancer, Dec 2024, Washington, United States. pp.S1, ⟨10.1016/j.jtho.2025.03.005⟩ Communication dans un congrès hal-05559002v1
The therapeutic targeting of human receptor activator of nuclear factor kappa-B ligand (RANKL) directly impairs colonization of the bone marrow by RANK-expressing human breast cancer cells in vivo Sofia Sousa,Evelyne Gineyts,Sandra Geraci,Lamia Bouazza,Martine Crosetet al. 2019 Annual Meeting of the American Society for Bone and Mineral Research Orange County Convention Center, Sep 2019, Orlando, United States Communication dans un congrès hal-05008787v1

Proceedings/Recueil des communications (1)

Actualités en recherche en oncologie : l’essentiel du cinquième Symposium International 2022 du Centre de recherche en cancérologie de Lyon Marie Alexandra Albaret,Eliezer Aïmontché,Nathalie Bendriss-Vermare,Jean-Jacques Diaz,Clara Gilet al. CRCL Fifth International Symposium, Bulletin du Cancer, 110 (12), pp.1332-1342, 2023, ⟨10.1016/j.bulcan.2023.07.003⟩ Proceedings/Recueil des communications hal-04480256v1

Thèse (1)

Le récepteur à dépendance TRKC : mécanismes moléculaires et implications dans la tumorigénèse Gabriel Ichim Agricultural sciences. Université Claude Bernard - Lyon I, 2012. English. ⟨NNT : 2012LYO10317⟩ Thèse tel-00936196v1