Gabriel MARKOV CRCN CNRS

Identifiants chercheurs

IdHAL :

gabriel-markov

ORCID :

0000-0002-8566-7482

IdRef :

155301837

VIAF :

305105995

ISNI :

0000000417181426

Présentation

I investigate metabolic pathway evolution, integrating information about the evolution of single enzymes with the distribution of metabolites accross lineages. This led me to develop methods to tackle directly the evolution of pathways at that level of abstraction. I am strongly interested about eukaryotic metabolic pathways for which there is a significant amount of detailed biological knowledge, such as those producing signaling molecules.

Publications

Article dans une revue (35)

Differential impact of copper stress in two Ectocarpales: metabolic disruption and defensive signaling in the free-living Ectocarpus sp7 and the endophytic Laminarionema elsbetiae Maëlle Zonnequin,Marine Vallet,Ludovic Delage,Georg Pohnert,Catherine Leblancet al. Biochimie, 2025, 239, pp.93-102. ⟨10.1016/j.biochi.2025.10.006⟩ Article dans une revue hal-05405218v1
Sterol biosynthesis and phytosterol bioconversion in Crassostrea gigas larvae: new evidence from mass-balance feeding studies Fiz da Costa,Margaux Mathieu-Resuge,Fabienne Le Grand,Claudie Quéré,Gabriel V. Markovet al. Biochimie, 2025, 239, Part A, pp.51-59. ⟨10.1016/j.biochi.2025.05.005⟩ Article dans une revue hal-05405141v1
Cholesterol and sterols in molluscan endocrinology: past, present, future István Fodor,Gabriel V. Markov,Luis Alfonso Yañez-Guerra,Károly Elekes,Edit Polláket al. Frontiers in Endocrinology, 2025, 16, ⟨10.3389/fendo.2025.1627166⟩ Article dans une revue hal-05405123v1
Plant and algal lipidomes: Analysis, composition, and their societal significance Juliette Jouhet,Eliana Alves,Yohann Boutté,Sylvain Darnet,Frédéric Domergueet al. Progress in Lipid Research, 2024, 96, pp.101290. ⟨10.1016/j.plipres.2024.101290⟩ Article dans une revue hal-04673335v1
Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems France Denoeud,Olivier Godfroy,Corinne Cruaud,Svenja Heesch,Zofia Nehret al. Cell, 2024, 187 (24), pp.6943-6965. ⟨10.1016/j.cell.2024.10.049⟩ Article dans une revue hal-04794231v1
A review on the chemical ecology of the Fucaceae holobionts: from fundamental knowledge to applications Coralie Rousseau,Gautier Demoulinger,Sylvie Rousvoal,Delphine Champeval,Maurane Dollyet al. Comptes Rendus. Chimie, 2024, 26 (S2), pp.1-25. ⟨10.5802/crchim.271⟩ Article dans une revue hal-04740350v1
Empirical evidence for metabolic drift in plant and algal lipid biosynthesis pathways Maëlle Zonnequin,Arnaud Belcour,Ludovic Delage,Anne Siegel,Samuel Blanquartet al. Frontiers in Plant Science, 2024, 15, pp.1339132. ⟨10.3389/fpls.2024.1339132⟩ Article dans une revue (article de synthèse) hal-04473577v1
Aldehyde perception induces specific molecular responses in Laminaria digitata and affects algal consumption by a specialist grazer Qikun Xing,Léa Cabioch,Antoine Desrut,Gildas Le Corguillé,Sylvie Rousvoalet al. The Plant Journal, In press, ⟨10.1111/tpj.16450⟩ Article dans une revue hal-04197531v1
Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA Abdul Kareem Mohideen Patel,Pierre Vilela,Tajith Baba Shaik,Alastair G Mcewen,Isabelle Hazemannet al. Nucleic Acids Research, 2023, 51 (16), pp.8864-8879. ⟨10.1093/nar/gkad632⟩ Article dans une revue hal-04234634v1
Inferring and comparing metabolism across heterogeneous sets of annotated genomes using AuCoMe Arnaud Belcour,Jeanne Got,Méziane Aite,Ludovic Delage,Jonas Collénet al. Genome Research, 2023, 33, pp.972 - 987. ⟨10.1101/gr.277056.122⟩ Article dans une revue hal-04192851v3
A novel nuclear receptor subfamily enlightens the origin of heterodimerization Brice Beinsteiner,Gabriel V Markov,Maxime Bourguet,Alastair G Mcewen,Stéphane Erbet al. BMC Biology, 2022, 20 (1), pp.217. ⟨10.1186/s12915-022-01413-0⟩ Article dans une revue hal-03843774v1
Independent Evolution of the MYB Family in Brown Algae Qiangcheng Zeng,Hanyu Liu,Xiaonan Chu,Yonggang Niu,Caili Wanget al. Frontiers in Genetics, 2022, 12, ⟨10.3389/fgene.2021.811993⟩ Article dans une revue hal-03938547v1
Small molecules as products of evolution Gabriel Markov,Vincent Laudet Current Biology, 2022, 32 (3), pp.R100-R105. ⟨10.1016/j.cub.2021.12.038⟩ Article dans une revue hal-03937973v1
A structural signature motif enlightens the origin and diversification of nuclear receptors Brice Beinsteiner,Gabriel V Markov,Stéphane Erb,Yassmine Chebaro,Alastair G Mcewenet al. PLoS Genetics, 2021, 17 (4), pp.e1009492. ⟨10.1371/journal.pgen.1009492⟩ Article dans une revue hal-03222330v1
Different Early Responses of Laminariales to an Endophytic Infection Provide Insights About Kelp Host Specificity Qikun Xing,Miriam Bernard,Sylvie Rousvoal,Erwan Corre,Gabriel Markovet al. Frontiers in Marine Science, 2021, 8, ⟨10.3389/fmars.2021.742469⟩ Article dans une revue hal-03454704v1
Semi-Quantitative Targeted Gas Chromatography-Mass Spectrometry Profiling Supports a Late Side-Chain Reductase Cycloartenol-to-Cholesterol Biosynthesis Pathway in Brown Algae Jean Girard,Goulven Lanneau,Ludovic Delage,Cédric Leroux,Arnaud Belcouret al. Frontiers in Plant Science, 2021, 12, pp.1-10. ⟨10.3389/fpls.2021.648426⟩ Article dans une revue hal-03222505v1
Biological rhythms in the deep-sea hydrothermal mussel Bathymodiolus azoricus Audrey Mat,Jozée Sarrazin,Gabriel Markov,Vincent Apremont,Christine Dubreuilet al. Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-17284-4⟩ Article dans une revue hal-02907599v1
The genome of Ectocarpus subulatus – A highly stress-tolerant brown alga Simon M. Dittami,Erwan Corre,Loraine Brillet-Guéguen,Agnieszka Lipinska,Noé Pontoizeauet al. Marine Genomics, 2020, 52, pp.100740. ⟨10.1016/j.margen.2020.100740⟩ Article dans une revue hal-02866117v1
Inferring Biochemical Reactions and Metabolite Structures to Understand Metabolic Pathway Drift Arnaud Belcour,Jean Girard,Méziane Aite,Ludovic Delage,Camille Trottieret al. iScience, 2020, 23 (2), pp.100849. ⟨10.1016/j.isci.2020.100849⟩ Article dans une revue hal-01943880v2
Diversity and evolution of cytochromes P450 in stramenopiles Linhong Teng,Xiao Fan,David R. Nelson,Wentao Han,Xiao Zhanget al. Planta, 2019, 249 (3), pp.647-661. ⟨10.1007/s00425-018-3028-1⟩ Article dans une revue hal-02065007v1
Genome–Scale Metabolic Networks Shed Light on the Carotenoid Biosynthesis Pathway in the Brown Algae Saccharina japonica and Cladosiphon okamuranus Delphine Nègre,Méziane Aite,Arnaud Belcour,Clémence Frioux,Loraine Brillet-Guéguenet al. Antioxidants , 2019, 8 (11), pp.564. ⟨10.3390/antiox8110564⟩ Article dans une revue hal-02395080v1
Hormonally active phytochemicals from macroalgae: a largely untapped source of ligands to deorphanize nuclear receptors in emerging marine animal models Gabriel V. Markov,Jean Girard,Vincent Laudet,Catherine Leblanc General and Comparative Endocrinology, 2018, 265, pp.41-45. ⟨10.1016/j.ygcen.2018.06.004⟩ Article dans une revue hal-02393542v1
Linking Genomic and Metabolomic Natural Variation Uncovers Nematode Pheromone Biosynthesis Jan Falcke,Neelanjan Bose,Alexander Artyukhin,Christian Rödelsperger,Gabriel V. Markovet al. Cell Chemical Biology, 2018, 25 (6), pp.787-796.e12. ⟨10.1016/j.chembiol.2018.04.004⟩ Article dans une revue hal-03941058v1
Traceability, reproducibility and wiki-exploration for &quot;à-la-carte&quot; reconstructions of genome-scale metabolic models Méziane Aite,Marie Chevallier,Clémence Frioux,Camille Trottier,Jeanne Gotet al. PLoS Computational Biology, 2018, 14 (5), pp.e1006146. ⟨10.1371/journal.pcbi.1006146⟩ Article dans une revue hal-01807842v1
NR3E receptors in cnidarians: A new family of steroid receptor relatives extends the possible mechanisms for ligand binding Konstantin Khalturin,Isabelle Billas,Yassmine Chebaro,Adam M. Reitzel,Ann M. Tarrantet al. Journal of Steroid Biochemistry and Molecular Biology, 2018, 184, pp.11-19. ⟨10.1016/j.jsbmb.2018.06.014⟩ Article dans une revue hal-02017750v1
Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogen Gabriel Markov,Juliana Gutierrez-Mazariegos,Delphine Pitrat,Isabelle M. L. Billas,François Bonnetonet al. Science Advances , 2017, 3 (3), pp.e1601778. ⟨10.1126/sciadv.1601778⟩ Article dans une revue hal-01693173v1
Functional Conservation and Divergence of&lt;i&gt;daf-22&lt;/i&gt;Paralogs in&lt;i&gt;Pristionchus pacificus&lt;/i&gt;Dauer Development Gabriel V. Markov,Jan M Meyer,Oishika Panda,Alexander B Artyukhin,Marc Claaßenet al. Molecular Biology and Evolution, 2016, 33 (10), pp.2506 - 2514. ⟨10.1093/molbev/msw090⟩ Article dans une revue hal-04460142v1
On the origin and evolutionary history of NANOG Pierluigi Scerbo,Gabriel V Markov,Céline Vivien,Laurent Kodjabachian,Barbara Demeneixet al. PLoS ONE, 2014, 9 (1), pp.e85104. ⟨10.1371/journal.pone.0085104⟩ Article dans une revue hal-01111124v1
Ventx factors function as Nanog-like guardians of developmental potential in Xenopus Pierluigi Scerbo,Fabrice Girardot,Céline Vivien,Gabriel V Markov,Guillaume Luxardiet al. PLoS ONE, 2012, 7 (5), pp.e36855. ⟨10.1371/journal.pone.0036855⟩ Article dans une revue hal-00843463v1
Origin and evolution of the ligand-binding ability of nuclear receptors Gabriel Markov,Vincent Laudet Molecular and Cellular Endocrinology, 2011, 334 (1-2), pp.21 - 30. ⟨10.1016/j.mce.2010.10.017⟩ Article dans une revue istex hal-02648059v1
Evolution of Nuclear Retinoic Acid Receptor Alpha (RAR alpha) Phosphorylation Sites. Serine Gain Provides Fine-Tuned Regulation Eric Samarut,Ismail Amal,Gabriel Markov,Roland Stote,Annick Dejaegereet al. Molecular Biology and Evolution, 2011, 28 (7), pp.2125 - 2137. ⟨10.1093/molbev/msr035⟩ Article dans une revue hal-02645447v1
Independent elaboration of steroid hormone signaling pathways in metazoans Gabriel V Markov,Raquel Tavares,Chantal Dauphin-Villemant,Barbara A. Demeneix,Michael E. Bakeret al. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (29), pp.11913-11918. ⟨10.1073/pnas.0812138106⟩ Article dans une revue hal-02666864v1
Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita Pierre Abad,Jerome Gouzy,Jean-Marc Aury,Philippe Castagnone-Sereno,Etienne Danchinet al. Nature Biotechnology, 2008, 26 (8), pp.909-915. ⟨10.1038/nbt.1482⟩ Article dans une revue hal-01189285v1
The evolution of the ligand/receptor couple: a long road from comparative endocrinology to comparative genomics Gabriel V Markov,Mathilde Paris,Stephanie Bertrand,Vincent Laudet Molecular and Cellular Endocrinology, 2008, 293 (1-2), pp.5. ⟨10.1016/j.mce.2008.06.011⟩ Article dans une revue hal-00532041v1
The &quot;street light syndrome&quot;, or how protein taxonomy can bias experimental manipulations Gabriel Markov,Guillaume Lecointre,Barbara Demeneix,Vincent Laudet BioEssays, 2008, 30 (4), pp.349-357. ⟨10.1002/bies.20730⟩ Article dans une revue istex hal-02662543v1

Communication dans un congrès (3)

Metagenome-scale metabolic modelling for the characterization of cross-feeding interactions in freshwater cyanobacteria-associated microbial communities Juliette Audemard,Nicolas Creusot,Julie Leloup,Charlotte Duval,Sébastien Halaryet al. JOBIM 2025 - Journées Ouvertes en Biologie, Informatique et Mathématiques, Jul 2025, Bordeaux, France Communication dans un congrès hal-05281552v1
Methods for a species-specific genome-scale metabolic model designed for eukaryotes and applied to the Ascophyllum nodosum macroalga Pauline Hamon-Giraud,Benoît Bergk Pinto,Jeanne Got,Coralie Rousseau,Erwan Correet al. JOBIM 2025 - Journées Ouvertes en Biologie, Informatique et Mathématiques, Jul 2025, Bordeaux, France. pp.109-117 Communication dans un congrès hal-05374724v1
Evolution of nuclear receptors in insects François Bonneton,Arnaud Chaumot,T. Iwema,I. Billas,D. Moraset al. 18th International Ecdysone Workshop 2010, Jul 2010, Ceske Budejovice, Czech Republic. pp.1 Communication dans un congrès hal-02593438v1

Poster de conférence (1)

Metagenome-scale metabolic modelling for the characterization of cross-feeding interactions in Microcystis-associated microbial communities, in the context of freshwater cyanobacterial blooms Juliette Audemard,Sébastien Halary,Gabriel Markov,Jeanne Got,Anne Siegelet al. JOBIM 2024 - Journées Ouvertes en Biologie, Informatique et Mathématiques, Jun 2024, Toulouse, France. pp.1-1, 2024 Poster de conférence hal-04654522v1

Chapitre d'ouvrage (2)

Evolution of hormonal mechanisms Brice Beinsteiner,Isabelle M.L. Billas,Dino Moras,Vincent Laudet,Gabriel V. Markov Ilpo Huhtaniemi, Luciano Martini. Encyclopedia of Endocrine Diseases, 3rd edition, Elsevier, 2025, 9780128122006. ⟨10.1016/B978-0-443-13825-6.00251-X⟩ Chapitre d'ouvrage hal-05405253v1
Evolution of Hormonal Mechanisms Vincent Laudet,Gabriel V. Markov Encyclopedia of Endocrine Diseases, Second Edition, 2018, 978-0-12-812200-6. ⟨10.1016/B978-0-12-812199-3.64198-1⟩ Chapitre d'ouvrage hal-03941018v1

Pré-publication, Document de travail (1)

The genome of Ectocarpus subulatus -a highly stress-tolerant brown alga Simon M. Dittami,Erwan Corre,Loraine Brillet-Guéguen,Agnieszka Lipinska,Méziane Aiteet al. 2019 Pré-publication, Document de travail hal-02333021v1

Rapport (1)

Biologie intégrative des organismes photosynthétiques et micro-organismes associés Cécile Raynaud,Laurent Nussaume,Fabrice Besnard,Ugo Cenci,Daniel Clesseet al. CNRS - Biologie intégrative des organismes photosynthétiques et micro-organismes associés (Section 23). 2025, pp.381-389 Rapport (rapport d’expertise collective) hal-05492655v1

Thèse (1)

Evolution of Steroid Signaling in Metazoans Gabriel Markov Agricultural sciences. Ecole normale supérieure de lyon - ENS LYON, 2011. English. ⟨NNT : 2011ENSL0634⟩ Thèse tel-01373637v1