Geoffrey Guittard

Publications

Pré-publication, Document de travail (1)

CAR T cells targeting Nectin-4 safely overcome resistance to anti-Nectin-4 antibody-drug conjugate in solid tumors Alexandrine Faivre,Léa Laban,Lorène Ferreira,Emmanuelle Josselin,Laurent Gorvelet al. 2025 Pré-publication, Document de travail hal-05398896v1

Article dans une revue (38)

Targeting BTN2A1 enhances Vγ9Vδ2 T-cell effector functions and triggers tumor cell pyroptosis Anne-Charlotte Le Floch,Caroline Imbert,Nicolas Boucherit,Laurent Gorvel,Stéphane Fattoriet al. Cancer Immunology Research, In press, 12 (12), pp.1677-1690. ⟨10.1158/2326-6066.CIR-23-0868⟩ Article dans une revue hal-04735873v1
Enhancing natural killer cells proliferation and cytotoxicity using imidazole-based lipid nanoparticles encapsulating interleukin-2 mRNA Christophe Delehedde,Ivan Ciganek,Pierre Louis Bernard,Nabila Laroui,Cathy Costa da Silvaet al. Molecular Therapy - Nucleic Acids, 2024, 35 (3), pp.102263. ⟨10.1016/j.omtn.2024.102263⟩ Article dans une revue hal-04772634v1
DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing Vladimir Laletin,Pierre-Louis Bernard,Camille Montersino,Yuji Yamanashi,Daniel Oliveet al. Scientific Reports, 2024, 14 (1), pp.15053. ⟨10.1038/s41598-024-66075-0⟩ Article dans une revue hal-04772643v1
DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing Vladimir Laletin,Pierre-Louis Bernard,Camille Montersino,Yuji Y. Yamamoto,Daniel Oliveet al. Scientific Reports, 2024, 14 (1), pp.15053. ⟨10.1038/s41598-024-66075-0⟩ Article dans une revue hal-04654761v1
Anti-HVEM mAb therapy improves antitumoral immunity both in vitro and in vivo, in a novel transgenic mouse model expressing human HVEM and BTLA molecules challenged with HVEM expressing tumors Clémence Demerlé,Laurent Gorvel,Marielle Mello,Sonia Pastor,Clara Degoset al. Journal for Immunotherapy of Cancer, 2023, 11 (5), pp.e006348. ⟨10.1136/jitc-2022-006348⟩ Article dans une revue hal-04114937v1
Production of CRISPRi-engineered primary human mammary epithelial cells with baboon envelope pseudotyped lentiviral vectors Sonia Pastor,Julien Wicinski,Emmanuelle Charafe-Jauffret,Els Verhoeyen,Geoffrey Guittardet al. STAR Protocols, 2023, 4 (1), pp.102055. ⟨10.1016/j.xpro.2023.102055⟩ Article dans une revue hal-04735885v1
Negative intracellular regulators of T-cell receptor (TCR) signaling as potential antitumor immunotherapy targets Vladimir Laletin,Pierre-Louis Bernard,Cathy Costa da Silva,Geoffrey Guittard,Jacques Nunes Journal for Immunotherapy of Cancer, 2023, 11 (5), pp.e005845. ⟨10.1136/jitc-2022-005845⟩ Article dans une revue (article de synthèse) hal-04114285v1
TET2 regulates immune tolerance in chronically activated mast cells Riccardo Rigo,Rabie Chelbi,Julie Agopian,Sebastien Letard,Aurélien Griffonet al. JCI Insight, 2022, 7 (7), pp.e004244. ⟨10.1172/jci.insight.154191⟩ Article dans une revue hal-04772652v1
XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation Laia Richart,Mary-Loup Picod-Chedotel,Michel Wassef,Manon Macario,Setareh Aflakiet al. Cell, 2022, 185 (12), pp.2164-2183.e25. ⟨10.1016/j.cell.2022.04.034⟩ Article dans une revue hal-03951681v1
CISH Expression Is Associated with Metastasis-Free Interval in Triple-Negative Breast Cancer and Refines the Prognostic Value of PDL1 Expression Laurys Boudin,Alexandre de Nonneville,Pascal Finetti,Geoffrey Guittard,Jacques Nuneset al. Cancers, 2022, 14 (14), pp.3356. ⟨10.3390/cancers14143356⟩ Article dans une revue hal-03765362v1
Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity Pierre-Louis Bernard,Rebecca Delconte,Sonia Pastor,Vladimir Laletin,Cathy Costa da Silvaet al. Journal for Immunotherapy of Cancer, 2022, 10 (5), pp.e004244. ⟨10.1136/jitc-2021-004244⟩ Article dans une revue hal-03773961v1
CISH Expression Is Associated with Metastasis-Free Interval in Triple-Negative Breast Cancer and Refines the Prognostic Value of PDL1 Expression Laurys Boudin,Alexandre de Nonneville,Pascal Finetti,Geoffrey Guittard,Jacques Nuneset al. Cancers, 2022, 14 (14), pp.3356. ⟨10.3390/cancers14143356⟩ Article dans une revue hal-04772648v1
NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS Rebecca Delconte,Geoffrey Guittard,Wilford Goh,Soroor Hediyeh-Zadeh,Robert Hennessyet al. Frontiers in Immunology, 2020, 11, ⟨10.3389/fimmu.2020.00075⟩ Article dans une revue hal-04772658v1
NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS Rebecca B. Delconte,Geoffrey Guittard,Wilford Goh,Soroor Hediyeh-Zadeh,Robert J. Hennessyet al. Frontiers in Immunology, 2020, 11, pp.75. ⟨10.3389/fimmu.2020.00075⟩ Article dans une revue hal-02533541v1
Une piste en immunothérapie du cancer Pierre-Louis Bernard,Vladimir Laletin,Sonia Pastor,Jacques Nunès,Geoffrey Guittard Médecine/Sciences, 2020, 36, pp.50-55. ⟨10.1051/medsci/2020195⟩ Article dans une revue inserm-03152135v1
Vitamin D Controls Tumor Growth and CD8+ T Cell Infiltration in Breast Cancer Esma Karkeni,Stephanie Morin,Berna Bou Tayeh,Armelle Goubard,Emmanuelle Josselinet al. Frontiers in Immunology, 2019, 10, pp.1307. ⟨10.3389/fimmu.2019.01307⟩ Article dans une revue hal-02528933v1
Vitamin D Controls Tumor Growth and CD8+ T Cell Infiltration in Breast Cancer Esma Karkeni,Stéphanie Morin,Berna Bou Tayeh,Armelle Goubard,Emmanuelle Josselinet al. Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.01307⟩ Article dans une revue hal-04772659v1
TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling Bochra Zidi,Christelle Vincent-Fabert,Laurent Pouyet,Marion Seillier,Amelle Vandeveldeet al. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (1), pp.211-216. ⟨10.1073/pnas.1809980116⟩ Article dans une revue hal-02145737v1
A Prime-Pull-Amplify Vaccination Strategy To Maximize Induction of Circulating and Genital-Resident Intraepithelial CD8+ Memory T Cells Nicolas Çuburu,Rina Kim,Geoffrey Guittard,Cynthia Thompson,Patricia Dayet al. Journal of Immunology, 2019, 202 (4), pp.1250-1264. ⟨10.4049/jimmunol.1800219⟩ Article dans une revue hal-04772662v1
Evolutionary and expression analyses reveal a pattern of ancient duplications and functional specializations in the diversification of the Downstream of Kinase (DOK) genes Geoffrey Guittard,Pierre Pontarotti,Samuel Granjeaud,Magda Rodrigues,Laurent Abi-Rachedet al. Developmental and Comparative Immunology, 2018, 84, pp.193-198. ⟨10.1016/j.dci.2018.02.011⟩ Article dans une revue hal-04772664v1
TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling Bochra Zidi,Christelle Vincent-Fabert,Laurent Pouyet,Marion Seillier,Amelle Vandeveldeet al. Proceedings of the National Academy of Sciences of the United States of America, 2018, 116 (1), pp.211-216. ⟨10.1073/pnas.1809980116⟩ Article dans une revue hal-04772663v1
Evolutionary and expression analyses reveal a pattern of ancient duplications and functional specializations in the diversification of the Downstream of Kinase (DOK) genes Geoffrey Guittard,Pierre Pontarotti,Samuel Granjeaud,Magda Rodrigues,Laurent Abi-Rachedet al. Developmental and Comparative Immunology, 2018, 84, pp.193-198. ⟨10.1016/j.dci.2018.02.011⟩ Article dans une revue inserm-02148721v1
The Cish SH2 domain is essential for PLC-gamma 1 regulation in TCR stimulated CD8(+) T cells Geoffrey Guittard,Ana Dios-Esponera,Douglas C. Palmer,Itoro Akpan,Valarie A. Barret al. Scientific Reports, 2018, 8 (5336), ⟨10.1038/s41598-018-23549-2⟩ Article dans une revue hal-02143617v1
The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells Geoffrey Guittard,Ana Dios-Esponera,Douglas Palmer,Itoro Akpan,Valarie Barret al. Scientific Reports, 2018, 8 (1), pp.5336. ⟨10.1038/s41598-018-23549-2⟩ Article dans une revue hal-04772666v1
Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient Mice Geoffrey Guittard,Devorah Gallardo,Wenmei Li,Nicolas Melis,Julian Luiet al. Frontiers in Immunology, 2017, 8, ⟨10.3389/fimmu.2017.00343⟩ Article dans une revue hal-04772669v1
Ionic immune suppression within the tumour microenvironment limits T cell effector function Robert Eil,Suman Vodnala,David Clever,Christopher Klebanoff,Madhusudhanan Sukumaret al. Nature, 2016, 537 (7621), pp.539-543. ⟨10.1038/nature19364⟩ Article dans une revue hal-04772670v1
Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance Douglas Palmer,Geoffrey Guittard,Zulmarie Franco,Joseph Crompton,Robert Eilet al. Journal of Experimental Medicine, 2015, 212 (12), pp.2095-2113. ⟨10.1084/jem.20150304⟩ Article dans une revue hal-04772671v1
Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules A Rodriguez-Peña,J Gomez-Rodriguez,R Kortum,D Palmer,Z Yuet al. Gene Therapy, 2015, 22 (10), pp.781-792. ⟨10.1038/gt.2015.48⟩ Article dans une revue hal-04772673v1
Absence of both Sos‐1 and Sos‐2 in peripheral CD4 + T cells leads to PI3K pathway activation and defects in migration Geoffrey Guittard,Robert Kortum,Lakshmi Balagopalan,Nicolas Çuburu,Phan Nguyenet al. European Journal of Immunology, 2015, 45 (8), pp.2389-2395. ⟨10.1002/eji.201445226⟩ Article dans une revue hal-04772674v1
An Emerging Role for PI5P in T Cell Biology. Jacques A. Nunès,Geoffrey Guittard Frontiers in Immunology, 2013, 4, pp.80. ⟨10.3389/fimmu.2013.00080⟩ Article dans une revue inserm-00828688v1
An Emerging Role for PI5P in T Cell Biology Jacques Nunès,Geoffrey Guittard Frontiers in Immunology, 2013, 4, ⟨10.3389/fimmu.2013.00080⟩ Article dans une revue hal-04772676v1
B7-DC-Ig Enhances Vaccine Effect by a Novel Mechanism Dependent on PD-1 Expression Level on T Cell Subsets Mikayel Mkrtichyan,Yana Najjar,Estella Raulfs,Linda Liu,Solomon Langermanet al. Journal of Immunology, 2012, 189 (5), pp.2338-2347. ⟨10.4049/jimmunol.1103085⟩ Article dans une revue hal-04772677v1
Evidence for a positive role of PtdIns5P in T‐cell signal transduction pathways Geoffrey Guittard,Eva Mortier,Hélène Tronchère,Guylène Firaguay,Audrey Gérardet al. FEBS Letters, 2010, 584 (11), pp.2455-2460. ⟨10.1016/j.febslet.2010.04.051⟩ Article dans une revue hal-04772679v1
Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways. Geoffrey Guittard,Eva Mortier,Hélène Tronchère,Guylène Firaguay,Audrey Gérardet al. FEBS Letters, 2010, 584 (11), pp.2455-60. ⟨10.1016/j.febslet.2010.04.051⟩ Article dans une revue inserm-00474713v1
Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. Geoffrey Guittard,Audrey Gérard,Sophie Dupuis-Coronas,Hélène Tronchère,Eva Mortieret al. Journal of Immunology, 2009, 182 (7), pp.3974-8. ⟨10.4049/jimmunol.0804172⟩ Article dans une revue inserm-00364224v1
Dok-4 is a novel negative regulator of T cell activation. Audrey Gérard,Marguerite Ghiotto,Camille Fos,Geoffrey Guittard,Daniel Compagnoet al. Journal of Immunology, 2009, 182 (12), pp.7681-9. ⟨10.4049/jimmunol.0802203⟩ Article dans une revue inserm-00374930v1
Dok-4 Is a Novel Negative Regulator of T Cell Activation Audrey Gérard,Marguerite Ghiotto,Camille Fos,Geoffrey Guittard,Daniel Compagnoet al. Journal of Immunology, 2009, 182 (12), pp.7681-7689. ⟨10.4049/jimmunol.0802203⟩ Article dans une revue hal-04772680v1
Cutting Edge: Dok-1 and Dok-2 Adaptor Molecules Are Regulated by Phosphatidylinositol 5-Phosphate Production in T Cells Geoffrey Guittard,Audrey Gérard,Sophie Dupuis-Coronas,Hélène Tronchère,Eva Mortieret al. Journal of Immunology, 2009, 182 (7), pp.3974-3978. ⟨10.4049/jimmunol.0804172⟩ Article dans une revue hal-04772682v1