Georg Mellitzer

Publications

Article dans une revue (28)

Evaluation of dual-function molecules containing both Zn-Ionophore and aggregation inhibition moieties for mutant p53 protein reactivation Kalvin Kwan,Ashkan Saffari,Lauryn Grcic,Alfredo Acosta,Grace Leechet al. Journal of Inorganic Biochemistry, 2026, 274, pp.113088. ⟨10.1016/j.jinorgbio.2025.113088⟩ Article dans une revue inserm-05314293v1
Inverse Correlation between Endoplasmic Reticulum Stress Intensity and Antitumor Immune Response with Ruthenium(II)-Based Photosensitizers for the Photodynamic Therapy of Head and Neck Squamous Cell Carcinoma Chloé Thibaudeau,Cyril Bour,Matthieu Scarpi-Luttenauer,Pierre Mesdom,Johannes Kargeset al. Journal of Medicinal Chemistry, 2025, ⟨10.1021/acs.jmedchem.5c02147⟩ Article dans une revue hal-05374218v1
Protoporphyrin IX-Derived Ruthenium(II) Complexes for Photodynamic Therapy in Gastric Cancer Cells Andrés Restrepo-Acevedo,María Isabel Murillo,Christophe Orvain,Chloé Thibaudeau,Sevda Recberliket al. Inorganic Chemistry, 2025, 64 (19), pp.9684-9702. ⟨10.1021/acs.inorgchem.5c00896⟩ Article dans une revue inserm-05210823v1
The unfolded protein response-glutathione metabolism axis: A novel target of a cycloruthenated complexes bypassing tumor resistance mechanisms Gilles Riegel,Christophe Orvain,Sevda Recberlik,Marie-Elodie Spaety,Gernot Poschetet al. Cancer Letters, 2024, 585, pp.216671. ⟨10.1016/j.canlet.2024.216671⟩ Article dans une revue hal-04721006v1
A novel ΔNp63-dependent immune mechanism improves prognosis of HPV-related head and neck cancer Jana Mourtada,Christelle Lony,Anaïs Nicol,Justine de Azevedo,Cyril Bouret al. Frontiers in Immunology, 2023, 14, pp.1264093. ⟨10.3389/fimmu.2023.1264093⟩ Article dans une revue hal-04440322v1
The EXTREME Regimen Associating Cetuximab and Cisplatin Favors Head and Neck Cancer Cell Death and Immunogenicity with the Induction of an Anti-Cancer Immune Response Justine de Azevedo,Jana Mourtada,Cyril Bour,Veronique Devignot,Philippe Schultzet al. Cells, 2022, 11 (18), ⟨10.3390/cells11182866⟩ Article dans une revue hal-04889946v1
Histone Deacetylase Functions in Gastric Cancer: Therapeutic Target? Amandine Badie,Christian Gaiddon,Georg Mellitzer Cancers, 2022, 14 (21), pp.5472. ⟨10.3390/cancers14215472⟩ Article dans une revue inserm-05281008v1
Morpho-functional analysis of patient-derived xenografts reveals differential impact of gastric cancer and chemotherapy on the tumor ecosystem, affecting immune check point, metabolism, and sarcopenia A. Venkatasamy,E. Guerin,W. Reichardt,V. Devignot,M P Chenardet al. Gastric Cancer, 2022, 26 (2), pp.220-233. ⟨10.1007/s10120-022-01359-w⟩ Article dans une revue hal-04295287v1
Isoforms of the p53 Family and Gastric Cancer: A Ménage à Trois for an Unfinished Affair Anais Blanchet,Agathe Bourgmayer,Jean-Emmanuel Kurtz,Georg Mellitzer,Christian Gaiddon Cancers, 2021, 13 (4), pp.916. ⟨10.3390/cancers13040916⟩ Article dans une revue hal-03451009v1
Ultrasound and Transcriptomics Identify a Differential Impact of Cisplatin and Histone Deacetylation on Tumor Structure and Microenvironment in a Patient-Derived In Vivo Model of Gastric Cancer Aina Venkatasamy,Eric Guerin,Anais Blanchet,Christophe Orvain,Véronique Devignotet al. Pharmaceutics, 2021, 13 (9), pp.1485. ⟨10.3390/pharmaceutics13091485⟩ Article dans une revue hal-03450657v1
Bypassing the Resistance Mechanisms of the Tumor Ecosystem by Targeting the Endoplasmic Reticulum Stress Pathway Using Ruthenium- and Osmium-Based Organometallic Compounds: An Exciting Long-Term Collaboration with Dr. Michel Pfeffer Christian Gaiddon,Isabelle Gross,Xiangjun Meng,Marjorie Sidhoum,Georg Mellitzeret al. Molecules, 2021, 26 (17), pp.5386. ⟨10.3390/molecules26175386⟩ Article dans une revue hal-03450715v1
The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms Marine Beck,Mathilde Baranger,Ahlam Moufok-Sadoun,Emilie Bersuder,Isabelle Hinkelet al. Oncogene, 2021, 40, pp.522-535. ⟨10.1038/s41388-020-01546-y⟩ Article dans une revue hal-03044463v1
Anticancer activity of ruthenium and osmium cyclometalated compounds: identification of ABCB1 and EGFR as resistance mechanisms Cynthia Licona,Jean-Baptiste Delhorme,Gilles Riegel,Vania Vidimar,Ricardo Cerón-Camachoet al. Inorganic Chemistry Frontiers, 2020, 7 (3), pp.678-688. ⟨10.1039/C9QI01148J⟩ Article dans une revue hal-03013615v1
A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53 Vania Vidimar,Cynthia Licona,Ricardo Cerón-Camacho,Eric Guérin,Pierre Coliatet al. Cancer Letters, 2019, 440-441, pp.145-155. ⟨10.1016/j.canlet.2018.09.029⟩ Article dans une revue inserm-02363227v1
HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway Marie-Elodie Spaety,Alexandre Gries,Amandine Badie,Aina Venkatasamy,Benoît Romainet al. Cancers, 2019, 11 (11), pp.1747. ⟨10.3390/cancers11111747⟩ Article dans une revue inserm-02363213v1
A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin Cynthia Licona,Marie-Élodie Spaety,Antonella Capuozzo,Moussa Ali,Rita Santamariaet al. Oncotarget, 2017, 8 (2), pp.2568-2584. ⟨10.18632/oncotarget.13711⟩ Article dans une revue hal-01483834v1
Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance Mun Juinn Chow,Cynthia Licona,Giorgia Pastorin,Georg Mellitzer,Wee Han Anget al. Chemical Science, 2016, 7 (7), pp.4117-4124. ⟨10.1039/c6sc00268d⟩ Article dans une revue inserm-02365338v1
Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63 Yannick von Grabowiecki,Paula Abreu,Orphee Blanchard,Lavinia Palamiuc,Samir Benosmanet al. eLife, 2016, 5, pp.e10528. ⟨10.7554/eLife.10528⟩ Article dans une revue inserm-02365332v1
Subcellular Localization and Transport Kinetics of Ruthenium Organometallic Anticancer Compounds in Living Cells: A Dose-Dependent Role for Amino Acid and Iron Transporters M Klajner,Cynthia Licona,L Fetzer,Pascal Hébraud,Georg Mellitzeret al. Inorganic Chemistry, 2014, 53 (10), pp.5150-5158. ⟨10.1021/ic500250e⟩ Article dans une revue hal-04684613v1
Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity Neal Anthwal,Michelle Pelling,Suzanne Claxton,Georg Mellitzer,Caitlin Collinet al. Disease Models & Mechanisms, 2013, ⟨10.1242/dmm.011916⟩ Article dans une revue hal-04006946v1
Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity Vania Vidimar,Xiangjun Meng,Marcelina Klajner,Cynthia Licona,Ludivine Fetzeret al. Biochemical Pharmacology, 2012, 84 (11), pp.1428-1436. ⟨10.1016/j.bcp.2012.08.022⟩ Article dans une revue istex hal-04654755v1
Enteroendocrine cells and lipid absorption Georges Mellitzer,Gerard Gradwohl Current Opinion in Lipidology, 2011, 22 (3), pp.171-175. ⟨10.1097/MOL.0b013e32834622a2⟩ Article dans une revue hal-04692450v1
Complex Regulation of p73 Isoforms after Alteration of Amyloid Precursor Polypeptide (APP) Function and DNA Damage in Neurons S Benosman,X Meng,Y von Grabowiecki,L Palamiuc,L Hritcuet al. Journal of Biological Chemistry, 2011, 286 (50), pp.43013-43025. ⟨10.1074/jbc.M111.261271⟩ Article dans une revue hal-05259710v1
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium François Gerbe,Johan van Es,Leila Makrini,Bénédicte Brulin,Georg Mellitzeret al. Journal of Cell Biology, 2011, 192 (5), pp.767-780. ⟨10.1083/jcb.201010127⟩ Article dans une revue hal-02459483v1
Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development Josselin Soyer,Lydie Flasse,Wolfgang Raffelsberger,Anthony Beucher,Christophe Orvainet al. Development (Cambridge, England), 2010, 137 (2), pp.203-212. ⟨10.1242/dev.041673⟩ Article dans une revue hal-04088194v1
GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist Nayeem Quayum,Alecksandr Kutchma,Suparna A. Sarkar,Kirstine Juhl,Gerard Gradwohlet al. Experimental Diabetes Research, 2008, 2008, ⟨10.1155/2008/312060⟩ Article dans une revue hal-04118007v1
Genetic determinants of pancreatic epsilon-cell development. R Scott Heller,Marjorie Jenny,Patrick Collombat,Ahmed Mansouri,Catherine Tomasettoet al. Developmental Biology, 2005, 286 (1), pp.217-24. ⟨10.1016/j.ydbio.2005.06.041⟩ Article dans une revue istex hal-00187550v1
STAT5 Involvement in the Differentiation Response of Primary Chicken Myeloid Progenitor Cells to Chicken Myelomonocytic Growth Factor Irina Woldman,Georg Mellitzer,Matthias Kieslinger,Dieter Buchhart,Andreas Meinkeet al. Journal of immunotherapy : official journal of the Society for Biological Therapy, 1997, 159 (2), pp.877-886 Article dans une revue inserm-05281177v1

Communication dans un congrès (2)

Tu1986 The Cadherin-Related Mucdhl Is Decreased in Stem Cell-Like Colon Tumors and Inhibits β-Catenin Signaling in a Non-Classical Way Mathilde Baranger,Georg Mellitzer,Laetitia Marisa,Elisabeth Martin,Isabelle Dulucet al. DDW2015, Digestive Disease Week, Washington, USA, 16-19 Mai 2015, May 2015, Washington, United States. pp.S-953, ⟨10.1016/S0016-5085(15)33252-2⟩ Communication dans un congrès hal-04801235v1
Mucdhl, a typical cadherin that decreases in type from colon &quot;cancer stem cell&quot; and inhibits the beta-catenin of unconventional way M. Baranger,Georg Mellitzer,L Marisa,Elisabeth Martin,Isabelle Dulucet al. 2ème Congrès de la SFC, Société Française du Cancer, Jun 2015, Paris, France. pp.127-128 Communication dans un congrès hal-04801443v1