Gérard Gradwohl Directeur de Recherche Inserm (DR1),Institut de Génétique et de Biologie Moléculaire et Cellulaire,1 rue laurent Fries,67404 Illkirch,Eurométropole Strasbourg, France

Identifiants chercheurs

IdHAL :

gerard-gradwohl

ORCID :

0000-0002-6730-2615

IdRef :

101547390

ResearcherID :

1145323

Publications

Article dans une revue (69)

Unraveling enteroendocrine cell lineage dynamics and associated gene regulatory networks during intestinal development Sara Jiménez,Florence Blot,Aline Meunier,Rishabh Kapoor,Valérie Schreiberet al. Biology Open, 2025, 14 (10), pp.bio062083. ⟨10.1242/bio.062083⟩ Article dans une revue inserm-05324757v2
Extracellular matrix-driven metabolic control of pancreatic endocrine lineage allocation Christine Ebeid,Adam Rump,Chenglei Tian,Anant Mamidi,Adèle de Arcangeliset al. EMBO Reports, 2025, Online ahead of print. ⟨10.1038/s44319-025-00610-6⟩ Article dans une revue inserm-05333685v1
Gut microbiota remodeling and intestinal adaptation to lipid malabsorption after enteroendocrine cell loss in adult mice Florence Blot,Justine Marchix,Miriam Ejarque,Sara Jiménez,Aline Meunieret al. Cellular and Molecular Gastroenterology and Hepatology, 2023, ⟨10.1016/j.jcmgh.2023.02.013⟩ Article dans une revue hal-04007457v1
De la biologie du développement à la thérapie cellulaire du diabète Valérie Schreiber,Gérard Gradwohl Médecine des Maladies Métaboliques, A paraître, ⟨10.1016/j.mmm.2023.05.009⟩ Article dans une revue hal-04124672v1
Characterization of cell-fate decision landscapes by estimating transcription factor dynamics Sara Jiménez,Valérie Schreiber,Reuben Mercier,Gérard Gradwohl,Nacho Molina Cell Reports Methods, 2023, pp.100512. ⟨10.1016/j.crmeth.2023.100512⟩ Article dans une revue (data paper) inserm-04140681v1
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network Valérie Schreiber,Reuben Mercier,Sara Jiménez,Tao Ye,Emmanuel García-Sánchezet al. Molecular metabolism, 2021, 53, pp.101313. ⟨10.1016/j.molmet.2021.101313⟩ Article dans une revue hal-03454968v1
Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells Kaare V. Grunddal,Sarah Tonack,Kristoffer L. Egerod,Jonanthan James Thompson,Natalia Petersenet al. Molecular metabolism, 2021, 51, ⟨10.1016/j.molmet.2021.101231⟩ Article dans une revue hal-03708073v1
Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Towards Goblet Cell Lineage in the Mouse Intestine Hui Joyce Li,Subir Ray,Alper Kucukural,Gerard Gradwohl,Andrew Leiter Cellular and Molecular Gastroenterology and Hepatology, 2021, 11 (2), pp.433-448. ⟨10.1016/j.jcmgh.2020.08.006⟩ Article dans une revue inserm-03455700v1
Ascl1 is required to specify a subset of ventromedial hypothalamic neurons Shaghayegh Aslanpour,Jessica M Rosin,Anjali Balakrishnan,Natalia Klenin,Florence Blotet al. Development (Cambridge, England), 2020, 147 (10), pp.dev180067. ⟨10.1242/dev.180067⟩ Article dans une revue inserm-03229584v1
A transcriptomic roadmap to α- and β-cell differentiation in the embryonic pancreas Léon van Gurp,Mauro Muraro,Tim Dielen,Lina Seneby,Gitanjali Dharmadhikariet al. Development (Cambridge, England), 2019, 146 (12), pp.dev173716. ⟨10.1242/dev.173716⟩ Article dans une revue inserm-02438309v1
Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production Julie Piccand,Constance Vagne,Florence Blot,Aline Meunier,Anthony Beucheret al. Molecular metabolism, 2019, 29, pp.24-39. ⟨10.1016/j.molmet.2019.08.007⟩ Article dans une revue hal-02361214v1
STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage S de Groef,D Renmans,Y Cai,G Leuckx,S Roelset al. Cell Death and Disease, 2016, 7 (6), pp.e2272-e2272. ⟨10.1038/cddis.2016.171⟩ Article dans une revue inserm-03455713v1
Expression and functional studies of the GDNF family receptor alpha 3 in the pancreas Laure Nivlet,Joel Herrmann,Delia Esteban Martin,Aline Meunier,Christophe Orvainet al. Journal of Molecular Endocrinology, 2016, 56 (2), pp.77-90. ⟨10.1530/JME-15-0213⟩ Article dans une revue inserm-03455716v1
Differentially Expressed MicroRNA-483 Confers Distinct Functions in Pancreatic β- and α-Cells Ramkumar Mohan,Yiping Mao,Shungang Zhang,Yu-Wei Zhang,Cheng-Ran Xuet al. Journal of Biological Chemistry, 2015, 290 (32), pp.19955-19966. ⟨10.1074/jbc.M115.650705⟩ Article dans une revue hal-04004363v1
Pairing-up SOX to kick-start beta cell genesis Anne Grapin-Botton,Philip Allan Seymour,Gerard Gradwohl Diabetologia, 2015, 58 (5), pp.859-861. ⟨10.1007/s00125-015-3539-2⟩ Article dans une revue hal-04314988v1
Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes Nico de Leu,Yves Heremans,Violette Coppens,Naomi van Gassen,Ying Caiet al. Diabetologia, 2014, 57 (1), pp.140-147. ⟨10.1007/s00125-013-3076-9⟩ Article dans une revue hal-04090217v1
Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells Julie Piccand,Perrine Strasser,David J. Hodson,Aline Meunier,Tao Yeet al. Cell Reports, 2014, 9 (6), pp.2219-2232. ⟨10.1016/j.celrep.2014.11.033⟩ Article dans une revue hal-04004335v1
Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice. Julie Piccand,Aline Meunier,Carole Merle,Zhengping Jia,Jean-Vianney Barnieret al. Diabetes, 2014, 63 (1), pp.203-15. ⟨10.2337/db13-0384⟩ Article dans une revue hal-01181234v1
Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity Neal Anthwal,Michelle Pelling,Suzanne Claxton,Georg Mellitzer,Caitlin Collinet al. Disease Models & Mechanisms, 2013, ⟨10.1242/dmm.011916⟩ Article dans une revue hal-04006946v1
Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes. Keith Al-Hasani,Anja Pfeifer,Monica Courtney,Nouha Ben-Othman,Elisabet Gjerneset al. Developmental Cell, 2013, epub ahead of print. ⟨10.1016/j.devcel.2013.05.018⟩ Article dans une revue hal-00843533v1
Pancreatic islet and progenitor cell surface markers with cell sorting potential J Hald,T Galbo,C Rescan,L Radzikowski,A Sprinkelet al. Diabetologia, 2012, 55 (1), pp.154-165. ⟨10.1007/s00125-011-2295-1⟩ Article dans une revue hal-04354737v1
Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development Anthony Beucher,Mercè Martin,Caroline Spenle,Martine Poulet,Caitlin Collinet al. Developmental biology, 2012, 361 (2), pp.277-285. ⟨10.1016/j.ydbio.2011.10.025⟩ Article dans une revue hal-04210579v1
The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice. Anthony Beucher,Elisabet Gjernes,Caitlin Collin,Monica Courtney,Aline Meunieret al. PLoS ONE, 2012, 7 (5), pp.e36449. ⟨10.1371/journal.pone.0036449⟩ Article dans une revue hal-00760293v1
The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation David E. Metzger,Malgorzata Gasperowicz,Florian Otto,James C. Cross,Gerard Gradwohlet al. Development, 2012, 139 (8), pp.1447--1456. ⟨10.1242/dev.072892⟩ Article dans une revue hal-05006977v1
Enteroendocrine cells and lipid absorption Georges Mellitzer,Gerard Gradwohl Current Opinion in Lipidology, 2011, 22 (3), pp.171-175. ⟨10.1097/MOL.0b013e32834622a2⟩ Article dans une revue hal-04692450v1
Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus Michelle Pelling,Neal Anthwal,David Mcnay,Gerard Gradwohl,Andrew Leiteret al. Developmental Biology, 2011, 349 (2), pp.406-416. ⟨10.1016/j.ydbio.2010.11.007⟩ Article dans une revue istex hal-04006971v1
Expression of neuropeptide Y and agouti-related peptide in the hypothalamic arcuate nucleus of newborn neurogenin3 null mutant mice Yuta Arai,Gerard Gradwohl,Yoko Kameda Cell and Tissue Research, 2010, 340 (1), pp.137-145. ⟨10.1007/s00441-009-0925-4⟩ Article dans une revue istex hal-04040219v1
Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival Georg Mellitzer,Anthony Beucher,Viviane Lobstein,Pascal Michel,Sylvie Robineet al. Journal of Clinical Investigation, 2010, 120 (5), pp.1708-1721. ⟨10.1172/JCI40794⟩ Article dans une revue hal-04004280v1
Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development Josselin Soyer,Lydie Flasse,Wolfgang Raffelsberger,Anthony Beucher,Christophe Orvainet al. Development (Cambridge, England), 2010, 137 (2), pp.203-212. ⟨10.1242/dev.041673⟩ Article dans une revue hal-04088194v1
Characterization of the proneural gene regulatory network during mouse telencephalon development Julia M. Gohlke,Olivier Armant,Frederick M. Parham,Marjolein V. Smith,Celine Zimmeret al. BMC Biology, 2008, 6, ⟨10.1186/1741-7007-6-15⟩ Article dans une revue hal-04098272v1
GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist Nayeem Quayum,Alecksandr Kutchma,Suparna A. Sarkar,Kirstine Juhl,Gerard Gradwohlet al. Experimental Diabetes Research, 2008, 2008, ⟨10.1155/2008/312060⟩ Article dans une revue hal-04118007v1
β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas Xiaobo Xu,Joke d'Hoker,Geert Stangé,Stefan Bonné,Nico de Leuet al. Cell, 2008, 132 (2), pp.197-207. ⟨10.1016/j.cell.2007.12.015⟩ Article dans une revue hal-04029896v1
Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Tatiana V Petrova,Antti Nykänen,Camilla Norrmén,Konstantin I Ivanov,Leif C Anderssonet al. Cancer Cell, 2008, 13 (5), pp.407-19. ⟨10.1016/j.ccr.2008.02.020⟩ Article dans une revue hal-00282904v1
Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation Vinciane Vanhorenbeeck,Marjorie Jenny,Jean-François Cornut,Gérard Gradwohl,Frédéric Lemaigreet al. Developmental Biology, 2007, 305 (2), pp.685-694. ⟨10.1016/j.ydbio.2007.02.027⟩ Article dans une revue istex hal-04120336v1
Transcription Factors in Pancreatic Development Merce Martin,Viviane Hauer,Mélanie Messmer,Christophe Orvain,Gérard Gradwohl Endocrine Development, 2007, pp.24-32. ⟨10.1159/000109602⟩ Article dans une revue hal-04117367v1
In vitro models of intestinal epithelial cell differentiation Patricia Simon-Assmann,N. Turck,M. Sidhoum-Jenny,Gérard Gradwohl,Michèle Kedinger Cell Biology and Toxicology, 2007, 23 (4), pp.241-256. ⟨10.1007/s10565-006-0175-0⟩ Article dans une revue istex hal-04106090v1
Temporal Control of Neurogenin3 Activity in Pancreas Progenitors Reveals Competence Windows for the Generation of Different Endocrine Cell Types Kerstin Johansson,Umut Dursun,Nathalie Jordan,Guoqiang Gu,Friedrich Beermannet al. Developmental Cell, 2007, 12 (3), pp.457-465. ⟨10.1016/j.devcel.2007.02.010⟩ Article dans une revue hal-04006988v1
Development of the endocrine pancreas Gérard Gradwohl Diabetes & Metabolism, 2006, 32 (5), pp.532-533. ⟨10.1016/S1262-3636(06)72807-5⟩ Article dans une revue hal-04093892v1
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas Georg Mellitzer,Stefan Bonné,Reini Luco,Mark van de Casteele,Nathalie Lenne-Samuelet al. EMBO Journal, 2006, 25 (6), pp.1344-1352. ⟨10.1038/sj.emboj.7601011⟩ Article dans une revue hal-04104930v1
Lack of TCF2/vHNF1 in mice leads to pancreas agenesis C. Haumaitre,E. Barbacci,M. Jenny,M. Ott,Gérard Gradwohlet al. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 (5), pp.1490-1495. ⟨10.1073/pnas.0405776102⟩ Article dans une revue hal-04129661v1
Genetic determinants of pancreatic epsilon-cell development. R Scott Heller,Marjorie Jenny,Patrick Collombat,Ahmed Mansouri,Catherine Tomasettoet al. Developmental Biology, 2005, 286 (1), pp.217-24. ⟨10.1016/j.ydbio.2005.06.041⟩ Article dans une revue istex hal-00187550v1
Genetic determinants of pancreatic ε-cell development R. Scott Heller,Marjorie Jenny,Patrick Collombat,Ahmed Mansouri,Catherine Tomasettoet al. Developmental Biology, 2005, 286 (1), pp.217-224. ⟨10.1016/j.ydbio.2005.06.041⟩ Article dans une revue istex inserm-05281112v1
Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Mercè Martín,Jabier Gallego-Llamas,Vanessa Ribes,Michèle Kedinger,Karen Niederreitheret al. Developmental Biology, 2005, 284 (2), pp.399-411. ⟨10.1016/j.ydbio.2005.05.035⟩ Article dans une revue istex hal-00187679v1
Pancreatic Islet Progenitor Cells in Neurogenin 3-Yellow Fluorescent Protein Knock-Add-On Mice Georg Mellitzer,Mercè Martín,Marjorie Sidhoum-Jenny,Christophe Orvain,Jochen Barthset al. Molecular Endocrinology, 2004, 18 (11), pp.2765-2776. ⟨10.1210/me.2004-0243⟩ Article dans une revue hal-04130831v1
Neurogenesis in hippocampal slice cultures Olivier Raineteau,Lotty Rietschin,Gérard Gradwohl,François Guillemot,Beat Gähwiler Molecular and Cellular Neuroscience, 2004, 26 (2), pp.241-250. ⟨10.1016/j.mcn.2004.01.003⟩ Article dans une revue istex hal-04132387v1
Opposing actions of Arx and Pax4 in endocrine pancreas development Patrick Collombat,Ahmed Mansouri,Jacob Hecksher-Sorensen,Palle Serup,Jens Krullet al. Genes and Development, 2003, 17 (20), pp.2591-2603. ⟨10.1101/gad.269003⟩ Article dans une revue hal-04138430v1
Transcriptional program of the endocrine pancreas in mice and humans Klaus H. Kaestner,Catherine S. Lee,L. Marie Scearce,John E. Brestelli,Athanasios Arsenliset al. Diabetes, 2003, 52 (7), pp.1604-1610. ⟨10.2337/diabetes.52.7.1604⟩ Article dans une revue hal-04143730v1
Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium Marjorie Jenny,Céline Uhl,Colette Roche,Isabelle Duluc,Valérie Guillerminet al. The EMBO Journal, 2002, 21 (23), pp.6338-6347. ⟨10.1093/emboj/cdf649⟩ Article dans une revue hal-03812784v1
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3 Yves Heremans,Mark van de Casteele,Peter In'T Veld,Gerard Gradwohl,Palle Serupet al. Journal of Cell Biology, 2002, 159 (2), pp.303-312. ⟨10.1083/jcb.200203074⟩ Article dans une revue hal-04145235v1
Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord Raffaella Scardigli,Carol Schuurmans,Gerard Gradwohl,François Guillemot Neuron, 2001, 31 (2), pp.203-217. ⟨10.1016/s0896-6273(01)00358-0⟩ Article dans une revue hal-04112682v1
Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium E. Cau,G. Gradwohl,S. Casarosa,R. Kageyama,F. Guillemot Development (Cambridge, England), 2000, 127 (11), pp.2323-2332. ⟨10.1242/dev.127.11.2323⟩ Article dans une revue hal-04007008v1
Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene &lt;i&gt;ngn3&lt;/i&gt; Patrick Jacquemin,Serge M. Durviaux,Jan Jensen,Catherine Godfraind,Gerard Gradwohlet al. Molecular and Cellular Biology, 2000, 20 (12), pp.4445-4454. ⟨10.1128/MCB.20.12.4445-4454.2000⟩ Article dans une revue hal-04128943v1
Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina Masato Hojo,Toshiyuki Ohtsuka,Nobuo Hashimoto,Gerard Gradwohl,François Guillemotet al. Development (Cambridge, England), 2000, 127 (12), pp.2515-2522. ⟨10.1242/dev.127.12.2515⟩ Article dans une revue hal-04092781v1
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas Gérard Gradwohl,Andrée Dierich,Marianne Lemeur,François Guillemot Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (4), pp.1607-1611. ⟨10.1073/pnas.97.4.1607⟩ Article dans une revue hal-04006991v1
Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation Toshiyuki Ohtsuka,Makoto Ishibashi,Gerard Gradwohl,Shigetada Nakanishi,François Guillemotet al. EMBO Journal, 1999, 18 (8), pp.2196-2207. ⟨10.1093/emboj/18.8.2196⟩ Article dans une revue hal-04027634v1
The bHLH Protein NEUROGENIN 2 Is a Determination Factor for Epibranchial Placode–Derived Sensory Neurons Carol Fode,Gérard Gradwohl,Xavier Morin,Andrée Dierich,Marianne Lemeuret al. Neuron, 1998, 20 (3), pp.483-494. ⟨10.1016/s0896-6273(00)80989-7⟩ Article dans une revue hal-04007011v1
Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors E. Cau,G. Gradwohl,C. Fode,F. Guillemot Development (Cambridge, England), 1997, 124 (8), pp.1611-1621. ⟨10.1242/dev.124.8.1611⟩ Article dans une revue hal-04007003v1
The activity of neurogenin1 is controlled by local cues in the zebrafish embryo Patrick Blader,Nadine Fischer,Gerard Gradwohl,François Guillemot,Uwe Strähle Development (Cambridge, England), 1997, 124 (22), pp.4557-4569. ⟨10.1242/dev.124.22.4557⟩ Article dans une revue hal-03831425v1
Restricted Expression of a Novel Murineatonal-Related bHLH Protein in Undifferentiated Neural Precursors Gérard Gradwohl,Carol Fode,François Guillemot Developmental Biology, 1996, 180 (1), pp.227-241. ⟨10.1006/dbio.1996.0297⟩ Article dans une revue hal-04006998v1
Vascularization of the mouse embryo: A study of flk-1, tek, tie, and vascular endothelial growth factor expression during development Daniel Dumont,Guo-Hua Fong,Mira Puri,Gérard Gradwohl,Kari Alitaloet al. Developmental Dynamics, 1995, 203 (1), pp.80-92. ⟨10.1002/aja.1002030109⟩ Article dans une revue hal-03836540v1
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. D Dumont,Gérard Gradwohl,G Fong,M Puri,M Gertsensteinet al. Genes and Development, 1994, 8 (16), pp.1897-1909. ⟨10.1101/gad.8.16.1897⟩ Article dans une revue hal-03835243v1
Expression in E. coli of the catalytic domain of rat poly(ADP-ribose)polymerase J Thibodeau,F Simonin,M Favazza,G Gradwohl,G Poirieret al. FEBS Lett, 1990, 264 (1), pp.81-3. ⟨10.1016/0014-5793(90)80770-j⟩ Article dans une revue hal-02371465v1
The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA G Gradwohl,J M De Murcia,M Molinete,F Simonin,M Kokenet al. Proceedings of the National Academy of Sciences of the United States of America, 1990, 87 (8), pp.2990-4. ⟨10.1073/pnas.87.8.2990⟩ Article dans une revue hal-02371463v1
Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity F Simonin,J Menissier-de Murcia,O Poch,S Muller,G Gradwohlet al. Journal of Biological Chemistry, 1990, 265 (31), pp.19249-56 Article dans une revue hal-02371467v1
Poly(ADP-ribose)polymerase: a novel finger protein A Mazen,J Menissier-de Murcia,M Molinete,F Simonin,G Gradwohlet al. Nucleic Acids Research, 1989, 17 (12), pp.4689-98. ⟨10.1093/nar/17.12.4689⟩ Article dans une revue hal-02371460v1
Expression of functional zinc finger domain of human poly(ADP-ribose)polymerase in E. coli G Gradwohl,J Ménissier De Murcia,M Molinete,F Simonin,G De Murcia Nucleic Acids Research, 1989, 17 (17), pp.7112. ⟨10.1093/nar/17.17.7112⟩ Article dans une revue hal-02371461v1
Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA J Menissier-de Murcia,M Molinete,G Gradwohl,F Simonin,G De Murcia J Mol Biol, 1989, 210 (1), pp.229-33. ⟨10.1016/0022-2836(89)90302-1⟩ Article dans une revue istex hal-02371462v1
Zinc-binding proteins detected by protein blotting A Mazen,G Gradwohl,G De Murcia Anal Biochem, 1988, 172 (1), pp.39-42. ⟨10.1016/0003-2697(88)90408-3⟩ Article dans une revue istex hal-02371456v1
Poly(ADP-ribose) polymerase forms loops with DNA G Gradwohl,A Mazen,G De Murcia Biochemical and Biophysical Research Communications, 1987, 148 (3), pp.913-9. ⟨10.1016/s0006-291x(87)80219-x⟩ Article dans une revue istex hal-02371453v1