Gildas BERTHO

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Publications

Article dans une revue (58)

Metabolic Heterogeneity in Diffuse Large B-Cell Lymphoma Cells Reveals an Innovative Antimetabolic Combination Strategy Leonardo Lordello,Stéphanie Nuan-Aliman,Karoline Kielbassa-Elkadi,Aurélie Montagne,Konstantina Kottaet al. Cancers, 2025, 17 (3), pp.394. ⟨10.3390/cancers17030394⟩ Article dans une revue (data paper) hal-05053122v1
Characterization of POP mixture redistribution and identification of their molecular signature in xenografted fat mice Théo Jamay,Philippe Noirez,Haidar Djemai,Layale Youssef,Justine Massiaset al. Environmental Pollution, 2025, 374, pp.126239. ⟨10.1016/j.envpol.2025.126239⟩ Article dans une revue hal-05079695v1
Methylglyoxal-Induced Glycation of Plasma Albumin: From Biomarker Discovery to Clinical Use for Prediction of New-Onset Diabetes in Individuals with Prediabetes Arsênio Rodrigues Oliveira,Chloé Chevalier,Matthieu Wargny,Victoria Pakulska,Cédric Caradeucet al. Clinical Chemistry, 2025, 71 (6), pp.688-699. ⟨10.1093/clinchem/hvaf035⟩ Article dans une revue hal-05387570v1
The analysis of the skeletal muscle metabolism is crucial for designing optimal exercise paradigms in type 2 diabetes mellitus Elias Abi Akar,Laure Weill,Mirella El Khoury,Cédric Caradeuc,Gildas Berthoet al. Molecular Medicine, 2024, 30 (1), pp.80. ⟨10.1186/s10020-024-00850-7⟩ Article dans une revue hal-05316643v1
Phytochemical Study of the Anthelminthic Potential of Guadeloupean Plant Biodiversity Tressy Cabald,Carine Marie-Magdeleine,Lucien Philibert,Cédric Caradeuc,Gildas Berthoet al. Pharmaceuticals, 2024, 17 (6), pp.774. ⟨10.3390/ph17060774⟩ Article dans une revue hal-04670316v1
Revisiting the nature and pharmacodynamics of tacrolimus metabolites Rudy Mevizou,Hassan Aouad,François-Ludovic Sauvage,Hélène Arnion,Emilie Pinaultet al. Pharmacological Research, 2024, 209, pp.107438. ⟨10.1016/j.phrs.2024.107438⟩ Article dans une revue hal-05291791v1
One touch is all it takes: the supramolecular interaction between ubiquitin and lanthanide complexes revisited by paramagnetic NMR and molecular dynamics Karen dos Santos,Alessio Bartocci,Natacha Gillet,Sandrine Denis-Quanquin,Amandine Rouxet al. Physical Chemistry Chemical Physics, 2024, 26 (20), pp.14573 - 14581. ⟨10.1039/d4cp00463a⟩ Article dans une revue hal-04609190v1
A Toolbox for Glutamine Use in Dissolution Dynamic Nuclear Polarization: from Enzymatic Reaction Monitoring to the Study of Cellular Metabolic Pathways and Imaging Karen dos Santos,Gildas Bertho,Cédric Caradeuc,Véronique Baud,Aurélie Montagneet al. ChemPhysChem, 2023, 24 (12), pp.e202300151. ⟨10.1002/cphc.202300151⟩ Article dans une revue hal-05543936v1
NMR metabolomics study of chronic low‐dose exposure to a cocktail of persistent organic pollutants Covadonga Lucas-Torres,Cédric Caradeuc,Laura Prieur,Haidar Djemai,Layale Youssefet al. NMR in Biomedicine, 2023, 36 (11), pp.e5006. ⟨10.1002/nbm.5006⟩ Article dans une revue hal-04182525v1
Ultrahigh-Resolution NMR with Water Signal Suppression for a Deeper Understanding of the Action of Antimetabolic Drugs on Diffuse Large B-Cell Lymphoma Gildas Bertho,Leonardo Lordello,Xi Chen,Covadonga Lucas-Torres,Imed Eddine Oumezzianeet al. Journal of Proteome Research, 2022, 21 (4), pp.1041-1051. ⟨10.1021/acs.jproteome.1c00914⟩ Article dans une revue hal-03648893v1
Structural analysis of unstable norbixin isomers guided by pure shift nuclear magnetic resonance Gildas Bertho,Imed Eddine Oumezziane,Cédric Caradeuc,Louis Guibout,Christine Balducciet al. Magnetic Resonance in Chemistry, 2022, 60 (5), pp.504-514. ⟨10.1002/mrc.5252⟩ Article dans une revue hal-03648920v1
Synthesis and characterization of novel conformers of ( E ) ‐ 2‐(3‐nitro‐ H ‐imidazo[1,2‐ a ]pyridin‐2‐ylthio)‐ N ′‐benzylideneacetohydrazide derivatives Evrard Ablo,Souleymane Coulibaly,Siomenan Coulibali,Kouassi Signo,Patrick‐armand Achiet al. Magnetic Resonance in Chemistry, 2022, ⟨10.1002/mrc.5308⟩ Article dans une revue hal-03812767v1
The complex metabolism of poststerone in male rats Christine Balducci,Laurence Dinan,Louis Guibout,Anne-Sophie Foucault,Christel Carbonneet al. Journal of Steroid Biochemistry and Molecular Biology, 2021, 212, pp.105897. ⟨10.1016/j.jsbmb.2021.105897⟩ Article dans une revue hal-03684677v1
On the Supra‐LUMO Interaction: Case Study of a Sudden Change of Electronic Structure as a Functional Emergence Alexis Gosset,Štěpánka Nováková Lachmanová,Sawsen Cherraben,Gildas Bertho,Jérémy Fortéet al. Chemistry - A European Journal, 2021, 27 (71), pp.17889-17899. ⟨10.1002/chem.202103136⟩ Article dans une revue hal-03684619v1
Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration Raoul Manuel,Michelle de Souza Lima,Sébastien Dilly,Sylvain Daunay,Patricia Abbeet al. Antioxidants , 2021, 10 (5), pp.723. ⟨10.3390/antiox10050723⟩ Article dans une revue hal-03248720v1
Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration Raoul Manuel,Michelle de Souza Lima,Sébastien Dilly,Sylvain Daunay,Patricia Abbeet al. Antioxidants , 2021, 10, ⟨10.3390/antiox10050723⟩ Article dans une revue hal-03990867v1
Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases Hélène Arnould,Vincent Baudouin,Anne Baudry,Luiz Ribeiro,Hector Ardila-Osorioet al. PLoS Pathogens, 2021, 17 (10), pp.e1009991. ⟨10.1371/journal.ppat.1009991⟩ Article dans une revue hal-03413478v1
Adenomyosis is associated with specific proton nuclear magnetic resonance (1H-NMR) serum metabolic profiles Mathilde Bourdon,Pietro Santulli,Fatiha Kateb,Khaled Pocate-Cheriet,Frederic Batteuxet al. Fertility and Sterility, 2021, 116 (1), pp.243-254. ⟨10.1016/j.fertnstert.2021.02.031⟩ Article dans une revue hal-03684698v1
The follicular fluid metabolome differs according to the endometriosis phenotype Khaled Pocate-Cheriet,Pietro Santulli,Fatiha Kateb,Mathilde Bourdon,Chloé Maignienet al. Reproductive BioMedicine Online, 2020, 41, pp.1023 - 1037. ⟨10.1016/j.rbmo.2020.09.002⟩ Article dans une revue hal-03493619v1
Endometriosis phenotypes are associated with specific serum metabolic profiles determined by proton-nuclear magnetic resonance Chloé Maignien,Pietro Santulli,Fatiha Kateb,Cédric Caradeuc,Louis Marcellinet al. Reproductive BioMedicine Online, 2020, 41, pp.640 - 652. ⟨10.1016/j.rbmo.2020.06.019⟩ Article dans une revue hal-03492022v1
Urinary metabolic profiling of asymptomatic acute intermittent porphyria using a rule-mining-based algorithm Margaux Luck,Caroline Schmitt,Neila Talbi,Laurent Gouya,Cédric Caradeucet al. Metabolomics, 2018, 14 (1), pp.10. ⟨10.1007/s11306-017-1305-9⟩ Article dans une revue hal-03684742v1
Real-Time and Non-invasive Monitoring of the Activation of the IRE1α-XBP1 Pathway in Individuals with Hemodynamic Impairment Baptiste Fohlen,Quentin Tavernier,Thi-Mum Huynh,Cédric Caradeuc,Delphine Le Correet al. EBioMedicine, 2018, 27, pp.284-292. ⟨10.1016/j.ebiom.2017.12.023⟩ Article dans une revue hal-03684748v1
Specific Physical Exercise Improves Energetic Metabolism in the Skeletal Muscle of Amyotrophic-Lateral- Sclerosis Mice Céline Desseille,Séverine Deforges,Olivier Biondi,Léo Houdebine,Domenico D’amicoet al. Frontiers in Molecular Neuroscience, 2017, 10, ⟨10.3389/fnmol.2017.00332⟩ Article dans une revue hal-03684756v1
Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25 Manal Sarkis,Maria Miteva,Maria Chiara Dasso Lang,Maryse Jaouen,Marie-Agnès Sariet al. Proteins: Structure, Function, and Bioinformatics, 2017, 85 (4), pp.593-601. ⟨10.1002/prot.25236⟩ Article dans une revue hal-03684762v1
Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25 Manal Sarkis,Maria Miteva,Maria Chiara Dasso Lang,Maryse Jaouen,Marie-Agnès Sariet al. Proteins: Structure, Function, and Bioinformatics, 2017, 85 (4), pp.593-601. ⟨10.1002/prot.25236⟩ Article dans une revue hal-03689998v1
Model of the Interaction between the NF-κB Inhibitory Protein p100 and the E3 Ubiquitin Ligase β-TrCP based on NMR and Docking Experiments Maxime Melikian,Baptiste Eluard,Gildas Bertho,Véronique Baud,Nathalie Evrard-Todeschi Journal of Chemical Information and Modeling, 2017, 57 (2), pp.223-233. ⟨10.1021/acs.jcim.5b00409⟩ Article dans une revue hal-03684765v1
Rule-Mining for the Early Prediction of Chronic Kidney Disease Based on Metabolomics and Multi-Source Data Margaux Luck,Gildas Bertho,Mathilde Bateson,Alexandre Karras,Anastasia Yartsevaet al. PLoS ONE, 2016, 11 (11), pp.e0166905. ⟨10.1371/journal.pone.0166905⟩ Article dans une revue hal-03684770v1
Interaction of a small molecule Natura-α and STAT3-SH2 domain to block Y705 phosphorylation and inhibit lupus nephritis J.W. Chiao,Maxime Melikian,Liying Han,Chengsen Xue,Allen Tsaoet al. Biochemical Pharmacology, 2016, 99, pp.123-131. ⟨10.1016/j.bcp.2015.11.018⟩ Article dans une revue hal-03684776v1
Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies. Lionel Ducassou,Gabriella Jonasson,Laura Dhers,Nicolas Pietrancosta,Booma Ramassamyet al. BBA - Biochimica et Biophysica Acta, 2015, 1850 (7), pp.1426-37. ⟨10.1016/j.bbagen.2015.03.014⟩ Article dans une revue hal-01449701v1
The urinary metabolome of chronic kidney disease Nicolas Pallet,Eric Thervet,Philippe Beaune,Alexandre Karras,Gildas Bertho Kidney International, 2014, 85 (5), pp.1239-1240. ⟨10.1038/ki.2014.34⟩ Article dans une revue hal-03684819v1
Novel RANK Antagonists for the Treatment of Bone-Resorptive Disease: Theoretical Predictions and Experimental Validation Stéphane Téletchéa,Verena Stresing,Soizic Hervouet,Marc Baud'Huin,Marie-Françoise Heymannet al. Journal of Bone and Mineral Research, 2014, 29 (6), pp.1466 - 1477. ⟨10.1002/jbmr.2170⟩ Article dans une revue inserm-01644748v1
Urinary Metabolic Fingerprint of Acute Intermittent Porphyria Analyzed by 1 H NMR Spectroscopy Mickael Carichon,Nicolas Pallet,Caroline Schmitt,Thibaud Lefebvre,Laurent Gouyaet al. Analytical Chemistry, 2014, 86 (4), pp.2166-2174. ⟨10.1021/ac403837r⟩ Article dans une revue hal-03684829v1
A new derivative detected in accelerated ageing of artesunate-amodiaquine fixed dose combination tablets Cedric Charrier,Gildas Bertho,Olivier Petigny,Philippe Moneton,Robert Azerad Journal of Pharmaceutical and Biomedical Analysis, 2013, 81-82, pp.20-26. ⟨10.1016/j.jpba.2013.03.009⟩ Article dans une revue istex hal-03684836v1
Thiolactone Sulfoxides as New Reactive Metabolites Acting as Bis-Electrophiles: Implication in Clopidogrel and Prasugrel Bioactivation Patrick Dansette,Dan Levent,Assia Hessani,Gildas Bertho,Daniel Mansuy Chemical Research in Toxicology, 2013, 26 (5), pp.794-802. ⟨10.1021/tx400083b⟩ Article dans une revue hal-03684856v1
Toward Stable Electron Paramagnetic Resonance Oximetry Probes: Synthesis, Characterization, and Metabolic Evaluation of New Ester Derivatives of a Tris-( para -carboxyltetrathiaaryl)methyl (TAM) Radical Christophe Decroos,Véronique Balland,Jean-Luc Boucher,Gildas Bertho,Yun Xu-Liet al. Chemical Research in Toxicology, 2013, 26 (10), pp.1561-1569. ⟨10.1021/tx400250a⟩ Article dans une revue hal-03684842v1
Naphthalene-dioxygenase catalysed cis-dihydroxylation of bicyclic azaarenes Claude Chopard,Gildas Bertho,Thierry Prangé RSC Advances, 2012, 2 (2), pp.605-615. ⟨10.1039/C1RA00706H⟩ Article dans une revue hal-03684941v1
Tryptophan Depletion and the Kinase GCN2 Mediate IFN-γ–Induced Autophagy Sophie Fougeray,Iadh Mami,Gildas Bertho,Philippe Beaune,Eric Thervetet al. Journal of Immunology, 2012, 189 (6), pp.2954-2964. ⟨10.4049/jimmunol.1201214⟩ Article dans une revue hal-03684891v1
Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis Patricia Rada,Ana Rojo,Nathalie Evrard-Todeschi,Nadia Innamorato,Axelle Cotteet al. Molecular and Cellular Biology, 2012, 32 (17), pp.3486-3499. ⟨10.1128/MCB.00180-12⟩ Article dans une revue hal-03684929v1
Contact-based ligand-clustering approach for the identification of active compounds in virtual screening Gildas Bertho,Alexey Mantsyzov,Guillaume Bouvier,Nathalie Evrard-Todeschi Advances and applications in bioinformatics and chemistry, 2012, pp.61. ⟨10.2147/AABC.S30881⟩ Article dans une revue hal-03684866v1
Cytochromes P450 Catalyze Both Steps of the Major Pathway of Clopidogrel Bioactivation, whereas Paraoxonase Catalyzes the Formation of a Minor Thiol Metabolite Isomer Patrick Dansette,Julien Rosi,Gildas Bertho,Daniel Mansuy Chemical Research in Toxicology, 2012, 25 (2), pp.348-356. ⟨10.1021/tx2004085⟩ Article dans une revue hal-03684944v1
Metabolic Activation of Prasugrel: Nature of the Two Competitive Pathways Resulting in the Opening of Its Thiophene Ring Patrick Dansette,Julien Rosi,Justine Debernardi,Gildas Bertho,Daniel Mansuy Chemical Research in Toxicology, 2012, 25 (5), pp.1058-1065. ⟨10.1021/tx3000279⟩ Article dans une revue hal-03684932v1
Paraoxonase-1 and clopidogrel efficacy Patrick Dansette,Julien Rosi,Gildas Bertho,Daniel Mansuy Nature Medicine, 2011, 17 (9), pp.1040-1041. ⟨10.1038/nm.2436⟩ Article dans une revue hal-03684957v1
Automatic clustering of docking poses in virtual screening process using self-organizing map Guillaume Bouvier,Nathalie Evrard-Todeschi,Jean-Pierre Girault,Gildas Bertho Bioinformatics, 2010, 26 (1), pp.53-60. ⟨10.1093/bioinformatics/btp623⟩ Article dans une revue hal-03684971v1
Formation and Fate of a Sulfenic Acid Intermediate in the Metabolic Activation of the Antithrombotic Prodrug Prasugrel Patrick Dansette,Stéphanie Thébault,Gildas Bertho,Daniel Mansuy Chemical Research in Toxicology, 2010, 23 (7), pp.1268-1274. ⟨10.1021/tx1001332⟩ Article dans une revue hal-03684983v1
Oxidative and Reductive Metabolism of Tris( p -carboxyltetrathiaaryl)methyl Radicals by Liver Microsomes Christophe Decroos,Yun Li,Gildas Bertho,Yves Frapart,Daniel Mansuyet al. Chemical Research in Toxicology, 2009, 22 (7), pp.1342-1350. ⟨10.1021/tx9001379⟩ Article dans une revue hal-03684990v1
Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel Patrick Dansette,Julie Libraire,Gildas Bertho,Daniel Mansuy Chemical Research in Toxicology, 2009, 22 (2), pp.369-373. ⟨10.1021/tx8004828⟩ Article dans une revue hal-03684993v1
Synthetic studies towards diazepanone scaffolds Christophe Decroos,Yun Li,Gildas Bertho,Yves Frapart,Daniel Mansuyet al. Tetrahedron: Asymmetry, 2009, 20 (20), pp.2320-2330. ⟨10.1016/j.tetasy.2009.09.022⟩ Article dans une revue istex hal-03685013v1
Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2˙− Christophe Decroos,Yun Li,Gildas Bertho,Yves Frapart,Daniel Mansuyet al. Chemical Communications, 2009, 11, pp.1416. ⟨10.1039/b819259f⟩ Article dans une revue istex hal-02102841v1
Transfer-NMR and Docking Studies Identify the Binding of the Peptide Derived from Activating Transcription Factor 4 to Protein Ubiquitin Ligase β-TrCP. Competition STD-NMR with β-Catenin Julien Pons,Nathalie Evrard-Todeschi,Gildas Bertho,Josyane Gharbi-Benarous,Valérie Tanchouet al. Biochemistry, 2008, 47 (1), pp.14-29. ⟨10.1021/bi7014212⟩ Article dans une revue istex hal-03685028v1
The key-role of tyrosine 155 in the mechanism of prion transconformation as highlighted by a study of sheep mutant peptides Gildas Bertho,Guillaume Bouvier,Gaston Hui Bon Hoa,Jean-Pierre Girault Peptides, 2008, 29 (7), pp.1073-1084. ⟨10.1016/j.peptides.2008.03.014⟩ Article dans une revue hal-03685032v1
Diastereoselective Additions to (3S)-3-Aminodehydrocaprolactams: Development of a Versatile Synthesis of New Substituted CyclicL-Lysines Camille Levraud,Sandrine Calvet-Vitale,Gildas Bertho,Hamid Dhimane European Journal of Organic Chemistry, 2008, 2008 (11), pp.1901-1909. ⟨10.1002/ejoc.200701004⟩ Article dans une revue istex hal-03685043v1
Structure of the Complex between Phosphorylated Substrates and the SCF β-TrCP Ubiquitin Ligase Receptor: A Combined NMR, Molecular Modeling, and Docking Approach Nathalie Evrard-Todeschi,Julien Pons,Josyane Gharbi-Benarous,Gildas Bertho,Richard Benarouset al. Journal of Chemical Information and Modeling, 2008, 48 (12), pp.2350-2361. ⟨10.1021/ci800248u⟩ Article dans une revue hal-03685021v1
Efficient synthesis of polyfunctionalised enantiopure diazepanone scaffolds Olivier Monasson,Maryon Ginisty,Gildas Bertho,Christine Gravier-Pelletier,Yves Le Merrer Tetrahedron Letters, 2007, 48 (46), pp.8149-8152. ⟨10.1016/j.tetlet.2007.09.098⟩ Article dans une revue istex hal-03685046v1
Allosteric tuning of the intra-cavity binding properties of a calix[6]arene through external binding to a Zn(II) center coordinated to amino arms Ulrich Darbost,Olivier Sénèque,Yun Li,Gildas Bertho,Jerome Marrotet al. Chemistry - A European Journal, 2006, 13, pp.2078-2088. ⟨10.1002/chem.200601040⟩ Article dans une revue istex hal-00391396v1
STD and TRNOESY NMR studies for the epitope mapping of the phosphorylation motif of the oncogenic protein beta-catenin recognized by a selective monoclonal antibody. Simon Megy,Gildas Bertho,Josyane Gharbi-Benarous,Françoise Baleux,Richard Benarouset al. FEBS Letters, 2006, 580 (22), pp.5411-22. ⟨10.1016/j.febslet.2006.08.084⟩ Article dans une revue istex pasteur-00166653v1
First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives Patrick M. Dansette,Gildas Bertho,Daniel Mansuy Biochemical and Biophysical Research Communications, 2005, 338, pp.450-455. ⟨10.1016/j.bbrc.2005.08.091⟩ Article dans une revue istex hal-00068627v1
Solution structure of a peptide derived from the oncogenic protein beta-Catenin in its phosphorylated and nonphosphorylated states. Simon Megy,Gildas Bertho,Josyane Gharbi-Benarous,Françoise Baleux,Richard Benarouset al. Peptides / Peptides (Fayetteville), 2005, 26 (2), pp.227-41. ⟨10.1016/j.peptides.2004.09.021⟩ Article dans une revue istex pasteur-00166821v1
Possible role of region 152-156 in structural duality of a peptide fragment from sheep prion protein Simon Megy,Gildas Bertho,Serguey A. Kozin,Marie Pascale M. P. Debey,Gaston Hui Bon Hoaet al. Protein Science, 2004, 13 (12), pp.3151-3160. ⟨10.1110/ps.04745004⟩ Article dans une revue hal-02677622v1

Communication dans un congrès (1)

Metabolic Profiling of 1H NMR Spectra in Chronic Kidney Disease with Local Predictive Modeling M.M. Luck,A. Yartseva,Gildas Bertho,E. Thervet,Philippe Beauneet al. 2015 IEEE 14th International Conference on Machine Learning and Applications (ICMLA), Dec 2015, Miami, France. pp.176-181, ⟨10.1109/ICMLA.2015.155⟩ Communication dans un congrès hal-03684787v1

Poster de conférence (2)

Characterization of diffuse large B-cell lymphoma subgroups by metabolomic analyses Nathalie Lacrampe,Emeline Chu-Van,Sylvain Dechaumet,Aurélie Montagne,Cédric Caradeucet al. 16e Journées Scientifiques du Réseau Francophone de Métabolomique et de Fluxomique, Jun 2024, Saint-Malo, France Poster de conférence hal-05149277v1
A NEW THIOPHENE METABOLITE: NADPH, O 2 AND THIOL DEPENDENT FORMATION OF A THIOPHENE HYDRATE FROM (S)-MTPPA BY CYP2C9 Patrick M. Dansette,Shigeyuki Kitamura,Gildas Bertho,Daniel Mansuy ISSX-JSSX joint symposium, Maui (Hawai) USA, novembre 2005, Nov 2005, Wailea, Maui, United States Poster de conférence hal-03515695v1